Warfarin interaction2

No. Supplements Possible MOA Potential Effect
Towards INR
1. Chlorella Contains large amount of vitamin
K
2. Chondroitin Inhibit activated factor X
3. Coenzyme Q10 Structurally related to
menaquinone (Vitamin K2)
4. Cranberry juice Contains flavonoids which may
alter metabolism of warfarin
5. Evening primrose oil Inhibit platelet aggregation
6. Fish oil supplement Omega-3 fatty acids may affect
platelet aggregation and/or
vitamin K-dependant coagulation
factors
7. Flaxseed oil Reduced platelet aggregation
8. Blackseed oil (Habbatus sauda) Unknown
9. Garlic Reduced platelet aggregation
10. Ginkgo Reduced platelet aggregation
11. Glucosamine Unknown
12. Grape seed supplement Contains tocopherol (one form of
vitamin E)
13. Minerals (Iron, magnesium and zinc) Iron, magnesium and zinc may
bind with warfarin, potentially
decreasing their absorption and
activity
14. Papain (papaya enzyme) Papain may damage mucous
membranes of the GI tract,
leading to increased risk of
bleeding
15. Probiotics Increase production of intestinal
vitamin K
16. Pumpkin seed Unknown. Usually when taken in
combination with saw palmetto
and vitamin E