Warfarin interaction2
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No. Herbal Possible MOA Potential Effect<br />
Towards INR<br />
1. Aloe vera When taken orally, aloe latex is a<br />
type of laxative called stimulant<br />
laxative. Stimulant laxatives<br />
speed up the bowels and can<br />
cause diarrhea in some people.<br />
Diarrhea can increase the effects<br />
of warfarin and increase the risk<br />
of bleeding<br />
2. Arnica Contains coumarin derivatives<br />
3. Anise (Bunga lawang) Contains coumarin derivatives<br />
4. Black tea Reduces warfarin effect and<br />
increase the risk of clotting. It iis<br />
unclear why this interaction<br />
might occur<br />
5. Celery Contains coumarin derivatives,<br />
which may possibly potentiate<br />
effect of warfarin<br />
6. Chamomile Contains coumarin derivatives,<br />
which may possibly potentiate<br />
effect of warfarin<br />
7. Clove (Bunga Cengkih) Exhibit antiplatelet activity<br />
8. Danshen Increased INR and prolonged<br />
PT/PTT (i.e. altered<br />
pharmacokinetics) by reducing<br />
elimination of warfarin, reduced<br />
platelet aggregation and TXA<br />
formation)<br />
9. Fenugreek (Halba) May contain coumarin<br />
derivatives<br />
10. Gamat Contains chondroitin<br />
11. Ginseng, American Induced CYP450 enzyme system<br />
activity and increased warfarin<br />
elimination<br />
12. Ginseng, Oriental Unknown<br />
13. Ginseng, Siberian Unknown<br />
14. Goji berry Unknown
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