Warfarin interaction2
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No. Food Possible MOA Potential Effect<br />
Towards INR<br />
15. King of bitter (Hempedu bumi) Its active chemical,<br />
Andrographolide, possessed<br />
antithrombotic activity via<br />
inhibition of platelet aggregation<br />
16. Kacip Fatimah Inhibit CYPC28, C29, 2C19<br />
activities<br />
17. Lotus seed Inhibit platelet aggregation and<br />
thrombus formulation<br />
18. Parsley May contain warfarin derivatives<br />
19. Senna Causes diarrhea, resulting in<br />
increased effect of warfarin<br />
20. Sky fruit (Buah tunjuk langit) Inhibit platelet-activating factor<br />
(PAF) and PAF-induced platelet<br />
aggregation<br />
21. St. John’s Wort Induced CYP2C9 and leads to<br />
increase metabolism of warfarin<br />
22. Tongkat Ali Contains major components of<br />
quassia which may increase the<br />
risk of bleeding when taken with<br />
drugs that increase the risk of<br />
bleeding<br />
23. Turmeric Inhibit platelet aggregation<br />
24. Wintergreen Contains methyl salicylate<br />
Modified from:<br />
MALAYSIAN PHARMACEUTICAL SOCIETY, <strong>Warfarin</strong> Interaction Handbook. 1 st ed. Selangor: Malaysian<br />
Pharmaceutical Society, 2017
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