Status and Future Directions of the - US Environmental Protection ...

Key Terms and Acronyms
1990 HPV Challenge
Program Chemical List
1994 List of HPV
Additions
Key Terms and Acronyms
The list of HPV Chemicals from the 1990 IUR reporting period, from which sponsors
may make chemical commitments to supply data.
Approximately 500 organic chemicals that were newly reported as HPV in the 1994
IUR, provided for use by companies in developing categories of chemicals.
ACC American Chemistry Council.
API American Petroleum Institute.
CAS Number Chemical Abstracts Service Number: A unique identification number assigned by the
Chemical Abstracts Service (CAS) to each distinct chemical substance recorded in
the CAS Chemical Registry System. This number may contain up to 9 digits. For
example, the CAS number for Valium is 439-14-5.
Category A group of substances similar in chemical structure that show a regular pattern of
properties and effects. In the HPV Challenge Program, being able to interpolate
between and among, or extrapolate from, category members often results in reduced
testing, since not all chemicals need to be tested for every SIDS endpoint.
Category Analysis A submitted plan where a sponsor indicates how their underlying category hypothesis
is reasonable, and how existing and new data can be interpolated/extrapolated to
address the untested category chemicals’ endpoints. EPA reviews the analysis and
considers whether it is reasonable or if the category should be considered for
restructuring.
Consortium An organization consisting of two or more companies that agree to sponsor at least
one chemical in the HPV Challenge Program.
EC European Commission: An organization that serves to operate in the best interest of
the European Union, specifically through proposing legislation, implementing policies,
enforcing law, and negotiating international agreements.
ED Environmental Defense.
EU European Union: An organization of democratic European countries that have
established common institutions to work toward prosperity.
Endpoint The chemical or biological effect that is assessed by a test method.
HPV High Production Volume: Chemicals manufactured or imported in quantities equal to
or greater than 1 million pounds per year.
HPVIS High Production Volume Information System: A publicly accessible website where
users will access comprehensive data related to HPV Challenge Program test plan
and robust summary submissions.
ICCA International Council of Chemical Associations: A chemical industry organization that
represents chemical manufacturers and producers from around the world, it adds
information transfer within the international industry.
IUCLID International Uniform Chemical Information Database: A system of data collection
and evaluation within the EU Risk Assessment Program and accepted by OECD as
the data exchange tool within the OECD Existing Chemicals Program.
IUR Inventory Update Rule: A rule promulgated in 1986 and revised extensively in 2003
by EPA that updates the TSCA Chemical Substances Inventory database every four
years. This rule requires manufacturers and importers of certain chemical
substances included on the TSCA Chemical Substances Inventory to report current
data on the production volume, plant site, and site-limited status of these substances.
Reporting in 2006 and beyond will include additional components.
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Status and Future Directions Status and Future Directions of the HPV Challenge Program – Final Draft – 10/19/04
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