Status and Future Directions of the - US Environmental Protection ...

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LogKow The octanol-water partition coefficient for a neutral molecule. It is generally used as
a relative indicator of the tendency of an organic compound to adsorb to soil.
NPPTAC National Pollution Prevention and Toxics Advisory Committee: National advisory
body to provide advice, information, and recommendations on the overall policy and
operation of programs managed by the Office of Pollution Prevention and Toxics
(OPPT).
OECD Organization for Economic Cooperation and Development: A group of 30 member
countries sharing a commitment to democratic government and the market economy,
covering economic and social issues such as macroeconomics, trade, education,
development, and science and innovation.
OPPT Office of Pollution Prevention and Toxics. EPA’s office wherein the HPV Challenge
Program is administered.
Orphan An unsponsored chemical from the 1990 HPV Challenge Program Chemical List that
may be manufactured or imported in quantities equal to or greater than one million
pounds in the last two IUR reporting periods.
PCRM Physicians Committee for Responsible Medicine.
PETA People for the Ethical Treatment of Animals.
Robust Summary An abridged reporting of data that includes the study objective, method, results, and
conclusions for one endpoint.
SAR Structure-Activity Relationship: An analysis in which a substance’s environmental
fate or effects relate to the substance’s molecular structure. For the HPV Challenge
Program, SAR is often used in category analyses where endpoint data for one
chemical can be used to cover endpoint data for another similar chemical.
SIAM SIDS Initial Assessment Meeting: A gathering of OECD member states to agree on
initial hazard assessment for HPV SIDS chemicals.
SIAR SIDS Initial Assessment Report: OECD member states’ evaluations, conclusions,
and recommendations for SIDS chemicals that are reviewed and accepted by the
OECD at the SIDS Initial Assessment Meeting.
SIDS Screening Information Data Set: An internationally agreed upon set of screening data
developed by the OECD, the SIDS consists of a chemical’s (1) general information,
(2) physical-chemical data, (3) environmental fate and pathways data, (4) ecotoxicity
data, and (5) toxicological data.
SOCMA Synthetic Organic Chemical Manufacturers Association: The primary trade
association serving the specialty-batch and custom chemical industry.
Start Year The year in which a sponsor commits to submit a chemical’s test plan and robust
summary.
Test Plan A summary of available and adequate data, with reference to a summary of data
gaps and a rationale for testing, if necessary.
Test Rule A TSCA Section 4 regulatory mechanism that requires testing of chemical
substances and mixtures for which the necessary findings have been made.
TSCA Toxic Substances Control Act: An Act created by Congress that gives EPA the ability
to assess and regulate industrial chemicals in the United States.
UNEP United Nations Environment Programme: An organization that provides leadership
and encourages partnership in caring for the environment. It informs and enables
nations to improve their quality of life in global and regional contexts.
Viable Chemical A chemical for which a commitment was made after December 26, 2000, and
therefore involves the submission of full studies in addition to robust summaries of
studies.
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Status and Future Directions of the HPV Challenge EPA’s Program High Production – Final Draft – Volume 10/19/04Challenge
Program