Wellness Foods & Supplements 2/2021

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No. 2, August/September <strong>2021</strong><br />

www.harnisch.com | ISSN 2364-8104<br />

Minerals Bioactives Natural energy<br />

Immune health Antioxidants Marine oils<br />

Skin health Active ingredients

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Editorial<br />

SILKE WATKINS, Editor-in-Chief<br />

Stress – not a good companion<br />

It happens every few years, when summer<br />

doesn’t want to begin and then turns out<br />

to be mixed. Ironically, after a seemingly<br />

endless winter and full of expectation, the<br />

expected spring and warm summer have<br />

been largely absent so far, at least in many<br />

Central European countries.<br />

I admit that I was not averse to the rain at first,<br />

but as it dragged on longer and longer, the<br />

days were grey, wet and cool, my first doubts<br />

arose. There were always a few hopeful<br />

warm and sunny days, but then the rain<br />

came back. The devastating consequences<br />

were floods and devastation of entire towns.<br />

At the same time, everyone longs to spend<br />

more time outdoors enjoying the sun again<br />

and finally spending time with family and<br />

friends. Light-heartedness, a word which has<br />

been far too little possible in the last one and<br />

a half years and which would do body and<br />

mind so much good, in short, simply doing<br />

something good for yourself and above all,<br />

avoiding stress as much as possible.<br />

Unfortunately, this is not always possible in<br />

everyday life; family and work demand a lot.<br />

Some are stressed by deadline pressure,<br />

others by the fact that they lack specific<br />

tasks. But less stress also means less<br />

physi cal fatigue, a better mood, healthier sleep and improved brain<br />

performance, not to mention healthy skin and, ultimately, healthier<br />

aging.<br />

The first step in changing the state of stress is to find out what<br />

causes the stress. Because only then, can you reduce it in a targeted<br />

manner. Perhaps one should question and change one’s attitude<br />

towards certain things in order to bring oneself “back into balance”,<br />

so to speak, “recharge your batteries with positive energy”. Even a<br />

well-cared for body can cope better with stressful situations. Some<br />

people can hardly eat a bite when they are under stress, while others<br />

are increasingly turning to sweet or fatty products. Ultimately, you are<br />

in a vicious circle and your digestion is no longer working well. A good<br />

supply of vitamins, minerals and plant substances has a beneficial<br />

effect on the nerves and psyche.<br />

The articles in this issue show which other possibilities exist to support<br />

a healthy lifestyle and a positive attitude towards life.<br />

I wish you an interesting read.<br />

Warmest regards<br />

Silke Watkins<br />

No. 2 August/September <strong>2021</strong><br />


Contents<br />

Health<br />

Convenience Food<br />

Food & Beverages<br />

Confectionary<br />

Cover Photo © : Indena<br />

Ubiqsome ® is part of Indena long tradition of<br />

Phytosome ® , successful and consolidated delivery<br />

system to optimize natural compounds bioavailability.<br />

Ubiqsome ® is an innovative formulation<br />

of Coenzyme Q10, industrially available and<br />

standardized to contain not less than 20 % of<br />

CoQ10. Ubiqsome ® allows to optimize coenzyme<br />

Q10 levels not only in human plasma but also in<br />

muscles, thus overcoming the bioavailability issue<br />

and making available on the market an ingredient<br />

able to exploit the great potential of such natural<br />

compound. (see article at page 6)<br />

Sports Nutrition<br />

Health Care<br />

Personal Care<br />

Contents<br />

Cover story<br />

06 Indena’s Ubiqsome ® : Coenzyme Q10 never so bioavailable<br />

Minerals<br />

08 Magnesium deficiency – a driving factor in insulin resistance, high blood pressure<br />

and cardiovascular diseases<br />

Bioactives<br />

12 Bone health and the benefits of bioactives<br />

Active ingredients in food supplements<br />

14 The future: Sustained-release supplements<br />

Natural energy<br />

16 Guayusa leaves: A natural source of energy from the Amazon<br />

Immune health<br />

18 How GELITA’s IMMUPEPT can help maintain the body’s own defence mechanism<br />

21 WEISHARDT, a relevant player in immune health<br />

Antioxidants<br />

24 Astaxanthin – oxidative balance for the body<br />

Marine Oils<br />

28 Seanova – a major player in the food supplements business<br />

Skin health<br />

32 Groundbreaking new study shows Pycnogenol ® may help retain skin moisture and elasticity,<br />

increase skin lightening, and reinforce skin barrier function<br />

34 Impressum<br />

4 No. 2 August/September <strong>2021</strong>

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Cover story<br />

Photo © : Indena<br />

Indena’s Ubiqsome ® : Coenzyme Q10 never<br />

so bioavailable<br />

Ubiqsome ® is part of Indena long tradition of Phytosome ® ,<br />

successful and consolidated delivery system to optimize<br />

natural compounds bioavailability. Ubiqsome ® is an innovative<br />

formulation of Coenzyme Q10, industrially available and<br />

standardized to contain not less than 20 % of CoQ10.<br />

Ubiqsome ® , thanks to the 100 % food-grade Phytosome ® delivery<br />

system, allows to optimize coenzyme Q10 levels not only in human<br />

plasma but also in muscles, thus overcoming the bioavailability issue<br />

and making available on the market an ingredient able to exploit the<br />

great potential of such natural compound.<br />

Phytosome ® has been developed since years specifically to face the<br />

issue of natural ingredients’ poor bioavailability: it’s Indena biomimetic<br />

strategy for the delivery of natural ingredients, allowing human<br />

body to absorb them in the best possible way, in the full respect of<br />

ingredients’ efficacy, safety and long-term tolerability. It is a fundamental<br />

asset, and an internationally recognized scientific reference.<br />

Phytosome ® combines food-grade sunflower<br />

lecithin with botanical and natural<br />

substances maintaining the original components’<br />

profile and benefits. Lecithins are<br />

natural surfactants which take part, together<br />

with bile salts, to the physiological absorption<br />

process of compounds and form the<br />

lipid bilayer structure of cell membranes. As<br />

amphipathic molecule consisting of a positively<br />

charged head group and two neutral<br />

tail acyl moieties, lecithin acts as inhibitor of<br />

self-aggregation, leaving natural compounds<br />

into a dispersed state more readily absorbed.<br />

Numerous scientific studies have proven<br />

that Phytosome ® system delivery offers optimized<br />

human pharmacokinetic profiles and<br />

effectiveness compared to non-formulated<br />

equivalent compounds.<br />

6 No. 2 August/September <strong>2021</strong>

Cover story<br />

As reported in literature, Coenzyme Q10<br />

plays a central role in generation and regulation<br />

of cell bioenergy, being involved in<br />

transferring of electrons within the mitochondrial<br />

oxidative respiratory chain and hence,<br />

ATP production. Coenzyme Q10 is very well<br />

known to have antioxidant and beneficial<br />

effects in optimizing human health and wellbeing.<br />

Endogenous levels of coenzyme Q10 are<br />

subject to decline for several reasons related<br />

with age, unhealthy conditions and after<br />

intense physical stress such as sport activity.<br />

In athletes, CoQ10 deficiency may also be<br />

experienced as metabolic stress and free<br />

radical formation is elevated during times<br />

of intense training, but the efficacy of oral<br />

supplementation is hampered by the low and<br />

highly variable bioavailability of co enzyme<br />

Q10.<br />

Ubiqsome ® is a highly bioavailable form of<br />

coenzyme Q10 which, according to results<br />

obtained in single and repeated pk studies in<br />

healthy volunteers, guarantees a significant<br />

optimization of physiological CoQ10 plasma<br />

levels after both one single dose (150 mg)<br />

with respect to CoQ10 not formulated, and<br />

after 2 weeks of supplementation with 2<br />

different daily dosages (150 and 300 mg).<br />

Furthermore, a dose-dependent profile has been also evidenced<br />

comparing results of Ubiqsome ® at the dose of 150 mg vs 300 mg.<br />

Ubiqsome ® displayed a good tolerance profile. No significant alterations<br />

in the vital signs, neither in the physical examination nor in ECG<br />

were observed.<br />

These findings support the safety profile and the optimized<br />

bio availability in humans of CoQ10 when administered in the<br />

Phytosome ® delivery formulation. Ubiqsome ® provided scientific and<br />

clinical evidence in sports nutrition as demonstrated in a randomized<br />

controlled human study in athletes (45–60 years of age). Thirty days<br />

supplementation with Ubiqsome ® led to a significant abundance of<br />

CoQ10 as plasmatic levels before and after sport training compared<br />

with the basal in subjects performing intense sport activity.<br />

Moreover, levels of coenzyme Q10 in muscles have been also evaluated,<br />

which revealed a significant presence of CoQ10 in muscles, the<br />

target tissue, after oral administration of Ubiqsome ® compared with<br />

the basal value as confirmed by HPLC (+36 %; p < 0.05).<br />

These unique evidences of positive modulation of muscular CoQ10<br />

levels highlight Ubiqsome ® as a promising and innovative ingredient<br />

for healthy benefits in sports nutrition.<br />

For more information, please contact<br />

Indena S.p.A.,<br />

Laura Bo, External communication<br />

and Sustainability<br />

laura.bo@indena.com<br />

www.indena.com<br />

Photo © : Adobe Stock/Svitlana<br />

No. 2 August/September <strong>2021</strong><br />


Minerals<br />

Photo © : Adobe Stock/Andreas Berheide<br />

Magnesium deficiency – a driving factor in<br />

insulin resistance, high blood pressure and<br />

cardiovascular diseases<br />

Philipp Gebhardt<br />

Magnesium is the fourth most abundant mineral in the human body.<br />

After potassium, magnesium is the most common cation in our<br />

cells. Sufficiently high magnesium concentrations are required for<br />

the blood pressure lowering hormone insulin to act on its receptor.<br />

Magnesium influences the vascular tone and the release of stress<br />

hormones such as norepinephrine. An inadequate supply of magnesium<br />

therefore increases the risk of insulin resistance, high blood<br />

pressure and cardiovascular diseases. Magnesium is mainly found in<br />

plant-based foods. Because of their lower calorie density, our ancestors'<br />

diet contained significantly more magnesium before the beginning<br />

of agriculture. In addition to an unbalanced diet, a magnesium<br />

deficiency is promoted by certain diseases and the use of various<br />

medications.<br />

An adult's body contains around 24 g of<br />

magnesium. About 40 % of the magnesium<br />

in the blood plasma is bound to proteins; the<br />

normal serum level is 1.8-2.6 mg/dl. Most of<br />

the magnesium is found in our bones, that<br />

can store it and release it when in times of<br />

poor intake. A normal magnesium blood<br />

level therefore does not rule out a magnesium<br />

deficiency. Magnesium is involved<br />

in more than 600 enzyme reactions as an<br />

enzyme component or coenzyme. Free<br />

magnesium ions influence the potential on<br />

cell membranes and act as second messen-<br />

8 No. 2 August/September <strong>2021</strong>

Minerals<br />

gers in the immune system. They stabilize<br />

the resting potential of excitable muscle and<br />

nerve cells and the cells of the autonomic<br />

nervous system. Magnesium is also an essential<br />

cofactor of the enzyme ATP synthase,<br />

which in the mitochondria, the “power plants<br />

of our cells”, regenerates adenosine diphosphate<br />

(ADP) to adenosine triphosphate<br />

(ATP), which is the universal energy carrier<br />

of our metabolism. As a magnesium-ATP<br />

complex, magnesium is involved in almost<br />

all energy-intensive processes.<br />

Vitamin C<br />

Folate<br />

Riboflavin<br />

Thiamine<br />

Vitamin A<br />

Vitamin E<br />

Appropriate nutrition.ai 1 01.05.<strong>2021</strong> 15:26:34<br />

≥ 10.000 Years ago <strong>2021</strong><br />

Calcium<br />

Iron<br />

1622 mg<br />

87,4 mg<br />

1143 mg<br />

15,2 mg<br />

Magnesium 1223 mg 397 mg<br />

Potassium 10,5 g 3,8 g<br />

Zinc<br />

43,4 mg 12,3 mg<br />

604 mg<br />

360 µg<br />

6,5 mg<br />

3,9 mg<br />

17,2 mg<br />

32,8 mg<br />

152 mg<br />

338 µg<br />

2,2 mg<br />

1,8 mg<br />

2,1 mg<br />

16,0 mg<br />

Fig. 1: Intake of various nutrients before the start<br />

of arable farming and today (estimate according<br />

to (1) or according to data from the National<br />

Consumption Study II, Max Rubner Institute<br />

(2008)). Compared to today's high-calorie and<br />

at the same time nutrient-poor food, the food<br />

supply more than 10,000 years ago provided<br />

significantly more fibre and between two and ten<br />

times more micronutrients.<br />

Due to their lower energy density and higher<br />

nutrient content, it is assumed that the diet<br />

of our ancestors contained significantly more<br />

magnesium before the beginning of agriculture<br />

(Fig. 1). From the data of the National<br />

Consumption Study II, a magnesium intake<br />

of 361 mg daily for women and 432 mg daily<br />

for men was calculated. It turned out that<br />

around 29 % of women and 26 % of men did<br />

not reach the recommended intake levels.<br />

However, there are also studies that show<br />

a daily magnesium intake of only around<br />

200 mg in women and 250 mg in men in<br />

Germany. (2)<br />

Diabetics are at particular risk of magnesium<br />

deficiency. If the blood sugar level is<br />

too high, more glucose is excreted through<br />

the kidneys. This leads to increased diuresis<br />

and a loss of magnesium with the urine. In inflammatory bowel<br />

disease, diarrhoea can lead to significant magnesium losses. In addition,<br />

various drugs interfere with magnesium metabolism. Therapy<br />

with diuretics promotes the excretion of magnesium via the kidneys.<br />

On the other hand, taking proton pump inhibitors leads to a reduced<br />

absorption of magnesium from food and over a long period of time,<br />

this can cause dangerous hypomagnesaemia. (3)<br />

Magnesium deficiency promotes insulin resistance and<br />

type 2 diabetes mellitus<br />

Diabetes mellitus is often associated with an inadequate magnesium<br />

status. For example, a study by the University Clinic in Zurich showed<br />

that 37.6 % of 109 participating type 2 diabetics had a clear magnesium<br />

deficiency. (4) Magnesium, however, plays a decisive role in the<br />

effect of insulin on its receptor (Fig. 2). The importance of a magnesium-rich<br />

diet was shown in a review that evaluated the data from<br />

more than 600,000 study participants. A higher magnesium intake<br />

was associated with a 17 % lower risk of developing type 2 diabetes<br />

mellitus. (5) In type 2 diabetes mellitus, magnesium supplementation<br />

can have a beneficial effect on blood sugar levels. (6)<br />

Insulin<br />

P<br />

normal<br />

Insulin action<br />

Magnesium<br />

Tyrosine kinase<br />

Phosphate<br />

ATP<br />

ADP<br />

Fig. 2: Sufficiently high intracellular magnesium concentrations are a<br />

prerequisite for the effect of the blood sugar-lowering hormone insulin on its<br />

receptor. Magnesium is required to transfer phosphate groups from ATP to<br />

the insulin receptor via the enzyme tyrosine kinase so that the insulin signal<br />

can be passed on into the cell. A magnesium deficiency leads, via reduced<br />

tyrosine kinase activity, to a reduced ability to activate the receptor by insulin<br />

and, as a result, promotes insulin resistance.<br />

Magnesium deficiency promotes high blood pressure<br />

In Germany, more than half of people over the age of 60 suffer from<br />

high blood pressure. Hypertension increases the risk of heart disease<br />

and strokes. In the treatment of high blood pressure, diuretics are<br />

often used. They withdraw water from the body and in this way<br />

lower the pressure in the vessels. However, essential minerals, especially<br />

magnesium, are also lost with the water. However, an insufficient<br />

supply of magnesium can result in an ion imbalance with nega-<br />

No. 2 August/September <strong>2021</strong><br />


Minerals<br />

tive effects on the natural regulation of blood pressure. An excess of<br />

calcium in the cells of the smooth muscles of the blood vessels leads<br />

to an increase in blood pressure via their contraction. Since magnesium<br />

forms a natural calcium antagonist, a magnesium deficiency<br />

can contribute to an increase in blood pressure via this mechanism.<br />

In contrast, a good magnesium status supports the function of ion<br />

pumps, which means that more potassium ions can get into the cell<br />

and calcium can be removed from the cytoplasm. (Fig. 3) Magnesium<br />

therefore has a vasodilator and blood pressure lowering effect.<br />

Vascular<br />

muscles<br />

Mg 2+<br />

1. 2.<br />

Ca 2+ Ca 2+<br />

Calcium channel Potassium channel<br />

Fig. 3: Magnesium forms a physiological counterpart to calcium. Magnesium<br />

reduces the influx of calcium into the cells of the smooth muscles [1].<br />

Magnesium also activates potassium channels, which promotes the outflow<br />

of calcium ions [2]. Lower intracellular calcium concentrations promote the<br />

relaxation of smooth muscle cells and favour normal blood pressure.<br />

Calcium also controls the release of norepinephrine, which increases<br />

the heart rate and elevates blood pressure. Magnesium can help<br />

normalize heart rate and blood pressure via a calcium-modulating<br />

effect. (Fig. 4) The blood pressure normalizing effect of magne-<br />

Mg 2+<br />

Ca 2+<br />

Nerve<br />

endings<br />

Norepinephrine<br />

Vasoconstriction<br />

Blood pressure<br />

Fig. 4: The neurotransmitter norepinephrine activates adrenoreceptors in the<br />

arterioles, causing constriction of these vessels (vasoconstriction) and thus<br />

increasing blood pressure. In adrenergic nerve endings, noradrenaline is released<br />

in a calcium-dependent manner. As calcium antagonists, magnesium<br />

ions inhibit the calcium influx into the nerve endings. With an adequate<br />

supply of magnesium, normal control of norepinephrine release and a reduction<br />

in high blood pressure can take place.<br />

sium supplementation could be confirmed<br />

in a meta-analysis which evaluated the<br />

data of a total of 1,173 either normotensive<br />

or hypertensive study participants. A<br />

significant reduction in blood pressure was<br />

demonstrated over a mean study period of<br />

around eleven months. A stronger effect<br />

was observed with higher doses of magnesium.<br />

(7) Together with the results of another<br />

review article (8), this indicates a blood pressure<br />

lowering effect in high blood pressure,<br />

but not in normal blood pressure.<br />

Magnesium deficiency promotes<br />

cardiovascular diseases<br />

Several large prospective cohort studies have<br />

examined magnesium intake with regard<br />

to cardiovascular diseases. In a recent<br />

analy sis of the Nurses' Health Study, which<br />

examined the data of nearly 90,000 nurses<br />

over a period of 28 years, those participants<br />

with the highest magnesium intake<br />

(> 342 mg/day) had a 39 % lower risk of fatal<br />

myocardial infarction compared to those<br />

participants with the lowest magnesium<br />

intake (< 246 mg/day). (9) In two reviews,<br />

each with more than 240,000 study participants,<br />

a higher magnesium intake was associated<br />

with a reduction in the risk of stroke<br />

by 8 to 11 %. (10, 11) A more recent metaanaly<br />

sis that evaluated the data from 15<br />

studies found that the risk of stroke was also<br />

11% lower with a higher compared to a lower<br />

magnesium intake. (12) Finally, a metaanaly<br />

sis with a total of over 500,000 participants<br />

showed a 15 % lower risk of cardiovascular<br />

events such as stroke, non-fatal<br />

myocardial infarction and coronary heart<br />

disease in connection with a higher magnesium<br />

intake. (13)<br />

Conclusion<br />

In addition to its important role in the energy<br />

metabolism, magnesium is of great importance<br />

for the effect of the blood sugar<br />

lowering hormone insulin. Adequate magnesium<br />

concentrations are a prerequisite for<br />

the body's ability to regulate blood pressure.<br />

Compared to a lower magnesium intake,<br />

a higher intake can significantly reduce<br />

the risk of type 2 diabetes mellitus, high<br />

10 No. 2 August/September <strong>2021</strong>

Minerals<br />

blood pressure and cardiovascular disease.<br />

Various authors therefore recommend<br />

supplementing 300 mg magnesium daily,<br />

in addition to the amounts contained in the<br />

diet. (14) Different magnesium compounds<br />

differ significantly in terms of their bioavailability.<br />

According to this, organic magnesium<br />

compounds such as citrate, glycinate<br />

and lactate can be absorbed much faster<br />

and better than inorganic salts such as<br />

carbonate or oxide. (15) A particularly interesting<br />

magnesium compound in this context<br />

is magnesium taurate, which contains<br />

around 8 % organically bound magnesium.<br />

Magnesium taurate is a source of the aminosulfonic<br />

acid taurine. As a powerful antioxidant,<br />

taurine can protect tissues from oxidative<br />

damage. Taurine is synthesized in the<br />

human metabolism. However, since this is<br />

only possible to a limited extent, a therapeutic<br />

application appears promising. Like<br />

magnesium, taurine appears to improve the<br />

function of calcium-transporting enzymes. In<br />

addition, taurine forms a non-ionic osmolyte<br />

that can promote the homeostasis of other<br />

ions within the cell. Taurine promotes the<br />

membrane binding of calcium. In the cells of<br />

the smooth muscles of the blood vessels, this<br />

leads to a vasodilating effect via an improved<br />

regulation of the calcium concentration. At<br />

doses between 1 and 6 g/day, a reduction in<br />

systolic blood pressure by up to 15 mmHg or<br />

diastolic blood pressure by up to 7 mmHg was shown. (16) A study<br />

with 120 pre-hypertensive partici pants showed a reduction of up to<br />

7.2 mmHg systolic or 4.7 mmHg diastolic with a daily supplementation<br />

of 1.6 g taurine for six weeks. (17) As an endogenous substance,<br />

taurine is characterized above all by the fact that no side effects are<br />

to be expected when used.<br />

References<br />

(1) Eaton, S. B., & Eaton Iii, S. B., European journal of nutrition, 39(2), 67-70 (2000)<br />

(2) Vormann, J., & Anke, M., Journal of Clinical and Basic Cardiology, 5(1), 49-53 (2002)<br />

(3) Shabajee, N., Lamb, E. J., et al., Bmj, 337 (2008)<br />

(4) Wälti, M. K., Spinas, G. A., et al., Swiss medical weekly, 133(1920) (2003)<br />

(5) Fang, X., Han, H., et al., Nutrients, 8(11), 739 (2016)<br />

(6) Veronese, N., Watutantrige-Fernando, S., et al., European journal of clinical nutrition,<br />

70(12), 1354-1359 (2016)<br />

(7) Kass, L., Weekes, J., et al., European journal of clinical nutrition, 66(4), 411-418 (2012)<br />

(8) Zhang, X., Li, Y., et al., Hypertension, 68(2), 324-333 (2016)<br />

(9) Chiuve, S. E., Sun, Q., et al., Journal of the American Heart Association, 2(2), e000114<br />

(2013)<br />

(10) Larsson, S. C., Orsini, N., et al., The American journal of clinical nutrition, 95(2),<br />

362-366 (2012)<br />

(11) Nie, Z. L., Wang, Z. M., et al., Nutrition, Metabolism and Cardiovascular Diseases, 23(3),<br />

169-176 (2013)<br />

(12) Zhao, B., Hu, L., et al., Frontiers in neurology, 10, 852 (2019)<br />

(13) Qu, X., Jin, F., et al., PloS one, 8(3), e57720 (2013)<br />

(14) DiNicolantonio, J. J., O’Keefe, et al., Open heart, 5(1), e000668 (2018)<br />

(15) Ranade, V. V., & Somberg, J. C., American journal of therapeutics, 8(5), 345-357 (2001)<br />

(16) Waldron, M., Patterson, S. D., et al., Current hypertension reports, 20(9), 81 (2018)<br />

(17) Sun, Q., Wang, B., et al., Hypertension, 67(3), 541-549 (2016)<br />

For more information, please contact<br />

Philipp Gebhardt<br />

65779 Kelkheim, Germany<br />

p.gebhardt@mitotherapie.de<br />




Scan the QR-code or visit www.magnesia.de/en/nutritional and<br />

learn more about magnesium compounds for your nutritional<br />

and health supplements products.<br />

MAGNESIA GmbH | Max-Jenne-Straße 2–4, 21337 Lüneburg, Germany | nutritional@magnesia.de | +49 4131 8710-37<br />

No. 2 August/September <strong>2021</strong><br />


Bioactives<br />

Photo © : Adobe Stock/AWavebreakMediaMicro<br />

Bone health and the benefits of bioactives<br />

Bones constantly regenerate throughout our lives and caring<br />

for them is essential. As we age, bones degenerate as their<br />

tissue decreases, which can lead to serious musculoskeletal<br />

conditions such as osteoporosis, rheumatoid arthritis and<br />

back pain. Bioactive compounds can improve bone health,<br />

particularly those present in milk-derived products.<br />

What are the commonest bone conditions?<br />

One of the most common bone diseases, especially with older people<br />

and women who have been through the menopause is osteoporosis,<br />

which affects 8.9 million people globally each year. This disease<br />

makes the bones fragile and susceptible to fracturing easily and often<br />

causes broken wrists, hips and spinal fractures. Even something as<br />

minor as a sneeze or cough can break a bone in a person with osteoporosis.<br />

The stage before osteoporosis is known as osteopenia and refers to<br />

low bone density, which also increases the risk of breaking a bone.<br />

Another prevalent disease that can damage<br />

the bones is rheumatoid arthritis. This is an<br />

autoimmune disease that has no cure and<br />

can move from joint to bone destruction.<br />

What is the impact of a musculoskeletal<br />

disease?<br />

These diseases can be debilitating and seriously<br />

impact lifestyle and work. In some<br />

cases long-term care may be required,<br />

meaning a loss of autonomy. In a society<br />

where we expect to live longer and continue<br />

to be active, maintaining bone health is<br />

important.<br />

Musculoskeletal diseases also have an<br />

impact on public health systems. In 2017<br />

close to 16 million people in England suffered<br />

12 No. 2 August/September <strong>2021</strong>

Bioactives<br />

OsteumCPP can be used to formulate various products to increase<br />

calcium absorption. These include drinks, yoghurts, baby and infant<br />

milk, dietary supplements and even pet food.<br />

This bioactive is beneficial at certain life stages:<br />

– childhood – when bones are developing and growing<br />

– pregnancy and breastfeeding – to strengthen the baby’s<br />

bone development<br />

– menopause – hormonal changes can reduce bone mass<br />

– later life – as bones degenerate over time<br />

from some form of musculoskele tal condition.<br />

According to UK government figures,<br />

the NHS spends approximately £5 billion<br />

each year on treating these conditions, a<br />

figure that could be reduced if these forms<br />

of disease could be prevented.<br />

How can bone conditions be avoided?<br />

Maintaining a healthy bone mass and<br />

strengthening the bones from an early age<br />

can help avoid severe bone conditions.<br />

Calcium is crucial for healthy bones, and can<br />

only be obtained through food or drinks, as<br />

the body does not make it naturally. This is<br />

why it is essential to ensure you get the right<br />

amount of calcium in your diet through dairy<br />

products. However, the digestive system only<br />

absorbs 15–20 % of the calcium we eat, yet<br />

bones are composed of 99 % calcium. This<br />

makes calcium supplemented products<br />

beneficial to health.<br />

What are bioactives?<br />

Photo © : Adobe Stock/Peera.P<br />

It can also be used to supplement products for other populations<br />

who do not belong to these groups, as healthy bones through good<br />

calcium absorption are beneficial to everyone.<br />

How do CPPs in Osteum work?<br />

As the body digests micellar casein it releases CPPs which transport<br />

calcium. CPPs are a binding agent that carries minerals such as<br />

calcium, iron and zinc which are beneficial to health. CPPs derived<br />

from micellar casein have a higher calcium-binding property than<br />

acid precipitated casein. They also prevent the formation of insoluble<br />

calcium salts which can be dangerous to health.<br />

OsteumCPP contains a high level of CPPs (a ratio of 25–35 %),<br />

which is one of the highest on the market.<br />

Therefore, a bioactive ingredient such as OsteumCPP is highly<br />

beneficial as a food, drink or supplement ingredient for all age groups<br />

in order to sustain healthy bones.<br />

References<br />

https://presse.inserm.fr/en/osteoporosis-balancing-bone-formation-and-degradation/17727/<br />

https://www.ingredia-nutritional.com/our-bioactifs/bone-joint-health/Osteum/<br />

file:///C:/Users/jehan/Downloads/OSTEUM_CPP_General_Presentation_2019%20(1).pdf<br />

https://www.who.int/news/item/27-10-2003-musculoskeletal-conditions-affect-millions<br />

https://theros.org.uk/information-and-support/osteoporosis/causes/<br />

https://medlineplus.gov/ency/article/002062.htm<br />

https://www.gov.uk/government/publications/musculoskeletal-health-applying-all-ourhealth/musculoskeletal-health-applying-all-our-health<br />

Bioactives are an ingredient derived from<br />

certain foods and can be added to other food<br />

or drink products to enhance health.<br />

OsteumCPP is a bioactive ingredient that<br />

contains casein phosphopeptides (CPPs)<br />

which are derived from milk. CPPs assist the<br />

body with the absorption of minerals such<br />

as calcium, which promotes healthy bones.<br />

This is a natural product that is produced<br />

from micellar casein, which is a high-quality<br />

protein.<br />

For more information, please contact<br />

Cecile DaCunha, product manager<br />

c.dacunha@ingredia.com<br />

Ingredia SA<br />

51 av F. Lobbedez - CS 60946<br />

62033 Arras Cedex, France<br />

www.ingredia.com<br />

No. 2 August/September <strong>2021</strong><br />


Active ingredients in food supplements<br />

All photos © : MBC/Adobe Stock/1123rf<br />

Fig. 1: Melatonin Sustained Release: 50 percent is released immediately in the first hour, followed by smaller and steadily decreasing doses.<br />

The „smart“ nutraceuticals<br />

The future: Sustained-release supplements<br />

Diana Kalustova<br />

Release characteristics have long been a topic in the<br />

pharma ceutical industry. Without controlled release, many<br />

important drugs could not fully exploit their potential,<br />

even though they had proven active ingredients. One good<br />

example of this is insulin, which was discovered in 1921.<br />

It quickly became clear that insulin was a substance that<br />

could effectively treat diabetes mellitus. However it was<br />

only with the development of insulin analogues that exist<br />

today, with extremely short to extremely long durations of<br />

action, that patients could be helped to achieve a better and<br />

longer life. Consequently, more and more manufacturers of<br />

food supplements show interest in slow-release forms, as<br />

they do recognize the resulting market opportunities. Using<br />

three examples from the well-known raw material manufacturer<br />

Nutriventia, we will show the innovation potential of<br />

this segment.<br />

In general, the following applies: Almost any raw material or active<br />

ingredient can be designed to have a delayed-release effect. The<br />

effect of sustained release is that the dietary supplement is released<br />

with a delay, evenly and over a longer period of time or in varying<br />

quantities. Sustained-release dietary supplements can be manufactured<br />

in the form of tablets, capsules, granules or powders.<br />

Sustained-release patches with an extended release of active ingredients<br />

are also possible. The galenics can also follow different routes.<br />

The most important manufacturing processes entail special coatings<br />

with a reservoir in the core, embedding in a polymer matrix as well<br />

as osmotically controlled systems, but also tablets and capsules with<br />

granules or pellets that are “preset” to dissolve. For dietary supplements,<br />

whose effect should only be developed in the intestines,<br />

sustained-relief forms can be produced that are enteric-coated.<br />

Slow/Modified Release<br />

Under the name “Slow/Modified Release”, Nutriventia has developed<br />

a process by which most ingredients for dietary supplements<br />

can be carefully adjusted to different release patterns. This allows<br />

the number of doses to be reduced, a purchasing factor that is especially<br />

important for older people. At the same time, their bioactivity<br />

is increased due to the controlled release. This has a positive effect<br />

on the amount of active ingredient required, which can therefore be<br />

lower and thus more sustainable. Slow/modified release thus often<br />

14 No. 2 August/September <strong>2021</strong>

Active ingredients in food supplements<br />

makes it much easier to implement many of<br />

the legislator’s rules (compliance).<br />

Example melatonin<br />

Melatonin is a hormone that in healthy people<br />

is produced primarily in the pineal gland,<br />

a part of the diencephalon, but also in the<br />

intestines and in the retina of the eye. It coordinates<br />

the circadian-rhythmic processes in<br />

the body, thus unfolding its effect as a timing<br />

agent or fatigue inducer. Together with adenosine,<br />

another endogenous hormone, melatonin<br />

controls the sleep rhythm.<br />

Vitamin C – An innovative approach<br />

Although Vitamin C cannot be produced by<br />

the human body itself, it performs a large<br />

number of tasks that are essential for maintaining<br />

health and physiological functions.<br />

Paramount in this regard is the immune<br />

defense, which cannot be maintained by the<br />

body without a sufficient supply of vitamin C.<br />

In the meantime, science has discovered that<br />

the human body rapidly degrades vitamin C<br />

and excretes it via the kidneys. Thus, the<br />

half-life of the plasma level of vitamin C is<br />

generally only about two hours. It follows<br />

Fig. 2: New study shows the C-Fence ® optimal Vitamin C plasma concentration over 24 hours.<br />

tifically confirmed that one C-Fence tablet<br />

provides a full protection for 24 hours.<br />

Proper use of caffeine<br />

Almost all people encounter a situation<br />

where they need to be wide awake. This<br />

means athletes, chess players and gamers,<br />

but also people on a holiday trip. In such situations,<br />

many people turn to highly caffeinated<br />

drinks (energy drinks) or consume pure<br />

caffeine in tablet or capsule form. Often they<br />

are surprised when they are more tired than<br />

ever after a short time, because the effect<br />

of caffeine increases quickly and decreases<br />

just as quickly. Nutriventia has therefore<br />

developed CaffXtend ® , a raw material that<br />

can be processed into tablets, capsules or<br />

powder. The product consists of natural<br />

caffeine, whose effect is “Slow/Modified”.<br />

The body thus always receives the amount<br />

of caffeine it needs to stay awake without<br />

harming health. Vivatis Pharma in Hamburg<br />

is the exclusive distributor for all Nutriventia<br />

products. Vivatis provides comprehensive<br />

advice on the subject of “Slow/Modified<br />

Release” – for raw materials and, if required,<br />

also for corresponding finished products.<br />

At the same time, melatonin fulfills important<br />

functions as an antioxidant and in the<br />

down-regulation of many other biologi cal<br />

processes. Infants and young children<br />

still produce large amounts of melatonin,<br />

but older people produce less and less –<br />

resulting in sleep disorders and sleep deprivation<br />

in the elderly. In view of the fact that<br />

melatonin is metabolized very quickly by the<br />

human body and its half-life is therefore no<br />

more than 40–60 minutes, it is understandable<br />

that supplementation becomes more<br />

effective to the extent that it is possible to<br />

provide the body with melatonin as required<br />

as so- called “long-acting melatonin”.<br />

Nutriventia has developed Melatonin<br />

Sustained Release specifically for this<br />

purpose. It is released in the body over the<br />

course of 8 hours in such a way (see Fig. 1)<br />

that it not only makes it possible to fall asleep<br />

more quickly, but also enables healthy sleep<br />

over the entire period, combined with a<br />

natural alternation of sleep phases.<br />

Fig. 3/CaffXtend ® : Better and healthier effects through continuous release over 12 hours<br />

that a constant plasma level of vitamin C is<br />

a prerequisite for this important vitamin to<br />

be fully effective. Nutriventia has therefore<br />

developed C-Fence ® , a sustained-release<br />

product that ensures that a total amount of<br />

500 mg of vitamin C is made available to<br />

the body over a period of 24 hours. This is<br />

exactly the amount considered to be optimal<br />

in order to permanently maintain the plasma<br />

level of vitamin C. It has now been scien-<br />

For more information, please contact<br />

Diana Kalustova<br />

Manager for Scientific Business<br />

Development,<br />

Vivatis Pharma GmbH<br />

info@vivatis.de<br />

www.vivatis.de<br />

No. 2 August/September <strong>2021</strong><br />


Natual energy<br />

Photo © : Waykana Ecuador<br />

Superfood from Ecuador<br />

Guayusa leaves: A natural source of energy<br />

from the Amazon<br />

The Amazon rain forest is the source of a very special energizer:<br />

guayusa, which comes from the leaves of the guayusa<br />

plant that the indigenous people of Ecuador, the Kichwa,<br />

traditionally use to make their energizing tea. The demand<br />

for guayusa tea is also growing here in Europe, whilst at the<br />

same time guayusa powder and extract are used in functional<br />

energy drinks, snacks and nutritional supplements. But what<br />

makes the superfood from Ecuador so special? What do<br />

its leaves contain? And what does guayusa taste like? The<br />

Import Promotion Desk (IPD), a project of Germany’s Federal<br />

Ministry for Economic Cooperation and Development (BMZ),<br />

is supporting producers from Ecuador in exporting guayusa<br />

from the Amazon to Europe.<br />

Ecuadorean pick-me-up<br />

Ilex guayusa is a holly bush that grows at high altitudes in the<br />

Amazon rain forest. Although guayusa is related to yerba mate, the<br />

two caffeinated holly plants are in fact different species. Guayusa has<br />

an established status in Amazonian culture:<br />

the indigenous people prize the stimulating<br />

tea, it is drunk at spiritual ceremonies and<br />

the leaves are used in traditional medicine.<br />

Ecuador is the world’s largest producer of<br />

guayusa leaves. The plants also grow in<br />

Bolivia and Peru, but in these countries the<br />

leaves are consumed mainly by locals and<br />

there is hardly any commercial production.<br />

With an average content of two percent,<br />

Guayusa leaves are highly caffeinated, but<br />

since the caffeine is released slowly and<br />

steadily, it is very well tolerated. The typical<br />

side effects of coffee, such as stomach<br />

pains, shaking and restlessness, are not<br />

present in guayusa. At the same time the<br />

energizing effect is longer-lasting and more<br />

16 No. 2 August/September <strong>2021</strong>

Natural energy<br />

Collaboration with small farmers<br />

The company Jumandipro-Waykana is a participant in the IPD<br />

programme. It works with 150 small Amazonian farmers in the rain<br />

forest to produce guayusa. Waykana pays its suppliers a wage that is<br />

15 percent higher than the standard Fairtrade rate and enables small<br />

farmers from four provinces to earn additional income. According to<br />

the firm’s owners, they were inspired by their awareness of just how<br />

unique and valuable guayusa from their rain forest is and how it can<br />

contribute to finding emotional balance in life.<br />

Guayusa production<br />

Photo © : Waykana Ecuador<br />

sustained. Guayusa is reportedly not only invigorating and able to<br />

increase sharpness and attentiveness, but also to improve performance.<br />

Guayusa grows in the Amazon rain forest and has been traditionally<br />

gathered by the indigenous community. Nowadays it is also cultivated<br />

by the communities for commercial use and the small farmers<br />

pluck the leaves by hand. Small farmers pick the leaves by hand, sort<br />

them, and gently dry them in the open air or in drying facilities. After<br />

harvesting, the guayusa leaves are spread on a surface to undergo a<br />

leaf selection process. Then they are pre-dried and packed in bags.<br />

During the dehydration process, the leaves are dried using an industrial<br />

drying oven. This is followed by grinding, sieving and final bulk<br />

packaging.<br />

For more information, please visit<br />

www.importpromotiondesk.de<br />

In addition, guayusa is credited with many nutritional benefits: the<br />

leaves contain twice as many antioxidants as normal green tea and<br />

antioxidants protect human cells from free radicals. Moreover, the<br />

guayusa leaves are rich in amino acids, vitamins C and D and the<br />

minerals potassium, magnesium, calcium, zinc and chromium.<br />

“Guayusa producers in Ecuador are confident in their tea with centuries<br />

of history,” says Maria Paula Gomez, IPD Expert Sourcing +<br />

Markets. “They offer a natural product with unique characteristics,<br />

they pay attention to the originality of their tea and carefully check the<br />

quality. For Europeans, Guayusa offers a special drinking pleasure;<br />

for producers and indigenous people in the Amazon, it's an important<br />

source of income.”<br />

Mild taste<br />

The taste of guayusa is comparable to that of mate tea. Although it is<br />

similarly earthy with slightly tart notes, it is much milder and does not<br />

have the bitterness of coffee or tea since the tannins found in many<br />

teas are not present in guayusa leaves. Guayusa has a delightfully<br />

smooth, delicate and slightly sweet taste making its leaves suitable<br />

not only for tea but also for refreshing drinks, energy drinks and even<br />

alcoholic beverages like beers and liqueurs. Guayusa is also already<br />

used in snacks and chocolate.<br />

No. 2 August/September <strong>2021</strong><br />


Immune health: Interview<br />

Photo © : Fotolia/ WavebreakMediaMicro<br />

Immune health: the collagen connection<br />

How GELITA’s IMMUPEPT can help<br />

maintain the body’s own defence mechanism<br />

We talked to Suzane Leser, Director of Nutrition Communication<br />

at GELITA, about the important link between specific<br />

Bioactive Collagen Peptides (BCP ® ) and immune support.<br />

We know that the pandemic has had a huge impact on people’s<br />

attitudes to lifestyle habits and immune health, in particular. So<br />

how best can they support their body’s own defences?<br />

It’s true that coronavirus has had a massive effect on people’s health<br />

habits, with recent research revealing that almost two-thirds of<br />

consumers are more conscious than ever before about their immune<br />

health i . But while everyone knows the importance of vitamins and<br />

minerals in immune support, not many know that collagen peptides<br />

can also make a vital contribution to a well-functioning immune<br />

system.<br />

Can you explain the connection between collagen and immunity?<br />

There are generally three lines of immune defence – surface barriers<br />

(notably the skin), the innate immunity, and the acquired immune<br />

response. From our research, we figured out one important thing the<br />

three lines of defence have in common: they are all supported by<br />

collagen-rich tissues. We want to bring attention<br />

to the fact that the skin forms the most<br />

ubiquitous first-line of immune defence.<br />

Also, that the whole-body extracellular<br />

matrix, which main component is collagen,<br />

is the terrain in which immune cells can<br />

operate and thrive against the pathogens that<br />

manage to cross the surface barriers. Finally,<br />

there is also the collagen-rich bone marrow,<br />

which is the organ that gives origin to all<br />

cells of the immune system, and serves as<br />

a reservoir of memory cells for the acquired<br />

immune response.<br />

We mentioned the outer skin as the body’s<br />

first barrier of immune defence, in a similar<br />

way, there is also the “inner skin” that works<br />

as important primary barriers, such as those<br />

found in the gut, lungs, eyes, and in the<br />

mucosa found in the nose and mouth, for<br />

example. These tissues are all supported<br />

by very similar cells and structural proteins,<br />

18 No. 2 August/September <strong>2021</strong>

Immune health: Interview<br />

such as collagen, found in the skin and in<br />

the extracellular matrix. Likewise, if these<br />

barriers are compromised, opportunistic<br />

pathogens can enter the body and trigger<br />

the innate immune response.<br />

The most obvious manifestation of the innate<br />

immune response is inflammation, which is<br />

a typical reaction to infection or injury. Such<br />

a reaction is completely normal, but when<br />

prolonged, it can lead to tissue damage<br />

and may eventually overwhelm the entire<br />

immune system. To avoid this, the third line<br />

of immune defence comes into play. This so<br />

called “adaptive” immunity is triggered when<br />

an infection progresses, despite the activity<br />

of the innate immune system. The adaptive<br />

immunity’s role is to learn and recognise<br />

the specific troublesome pathogens and, if<br />

exposed to them a second time, trigger a<br />

stronger, more rapid response. This adaptive<br />

mechanism, as mentioned, is regulated by<br />

cells and organs in the body, including the<br />

collagen-rich bone marrow.<br />

So what role do collagen peptides actually play?<br />

Essentially, the collagen peptides that are particularly bioactive, they<br />

can regulate the metabolism of connective tissue cells, and help keep<br />

the collagen-rich tissues involved in the immune response intact and<br />

metabolically active. Taking the skin barrier, for example, the epidermis<br />

is a wall of keratinocyte cells, and the spaces between these cells are<br />

filled with “scaffolding” extracellular matrix proteins, and are covered<br />

by lipids. If this layer is broken down, pathogens can get access to<br />

deeper tissues and cause infection. GELITA’s IMMUPEPT contains<br />

skin-specific Bioactive Collagen Peptides that have been optimised<br />

to stimulate the metabolism of keratinocytes, therefore regulating the<br />

production of proteins that form a strong skin barrier ii . These specific<br />

collagen peptides help keep the skin surface intact, so that it can<br />

withstand external threats.<br />

But surely immunity is more than skin deep…<br />

For sure. The role of connective tissues in immune health extends<br />

to the whole body extracellular matrix. This matrix is a three-dimensional<br />

environment, created by the connective tissue cells themselves,<br />

and in which most immune cells are mobile and operate.<br />

The matrix is abundant not only in collagen fibres, but also in several<br />

other functional proteins, and plays a crucial role in numerous meta-<br />

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Immune health: Interview<br />

bolic functions – including the immune response. In short, all components<br />

of the extracellular matrix are active partners in coordinating<br />

the different parts of the immune system.<br />

learn more and more about the importance of healthy bones for a<br />

well-functioning immune system, it’s important to also highlight the<br />

significant role that bone-specific collagen peptides can play in regulating<br />

the metabolism of bone-remodelling cells osteoblasts and osteoclasts.<br />

Hence, we also brought bone-specific Bioactive Collagen<br />

Peptides into IMMUPEPT.<br />

The benefits of these specific collagen peptides for bone health were<br />

confirmed in a human randomised controlled trial, where osteopenic<br />

postmenopausal women were supplemented daily with 5 g of bonespecific<br />

BCP ® for 12 months. During this time, the women saw a<br />

significant increase in bone mineral density, a superb outcome for<br />

women in that age group.<br />

Product-specific preclinical trials have also confirmed that the<br />

selected Bioactive Collagen Peptides in IMMUPEPT are also able to<br />

downregulate important biomarkers of inflammation, tissue damage<br />

and oxidative stress, suggesting an immune-modulatory effect from<br />


Photo © : GELITA<br />

How important, then, are these collagen peptides to the ECM?<br />

The Bioactive Collagen Peptides in IMMUPEPT have been shown<br />

to regulate the metabolism of fibroblasts – the most abundant cells<br />

of the connective tissue, the metabolic active centres of the extracellular<br />

matrix. The fibroblast-specific BCP ® s in IMMUPEPT stimulate<br />

these cells to produce the structural and functional extracellular<br />

matrix components, that play a role in the immune response.<br />

A product-specific randomised controlled trial, involving 114 women<br />

aged between 45 and 65, confirmed a statistically significant increase<br />

in Procollagen Type I (65 %), a marker of collagen formation, after 8<br />

weeks of daily supplementation with 2.5 g of fibroblast-specific BCP ® .<br />

Collagen type I is the main structural protein in the body, but it also<br />

has an immune regulatory role, acting to downregulate inflammation.<br />

Previously, you also mentioned bone marrow as an area of interest.<br />

Why is this?<br />

So now that the link between collagen and immune health has<br />

been established, what opportunities does this present for manufacturers<br />

of nutraceuticals, and functional food and drink pro ducts?<br />

With the introduction of a family of Bioactive Collagen Peptides,<br />

GELITA is able to offer manufacturers innovative solutions that help<br />

support a well-functioning immune system: the selected BCP ® s in<br />

IMMUPEPT 25 stimulate keratinocyte cells in the skin barrier,<br />

and fibroblast cells in the whole-body extracellular matrix, while<br />

IMMUPEPT 50 adds bone-specific BCP ® s to the mix, contributing<br />

stimulatory effects to the metabolism of the bone cells osteoblasts<br />

and osteoclasts. These collagen peptides can be used in drinks,<br />

shakes, powders and protein bars, without affecting their taste, smell<br />

or mouthfeel. They are also allergen-free and clean-label friendly.<br />

References<br />

i<br />

FMCG Gurus Survey, July 2019 ‘Changing consumption habits in the wake of COVID-19’<br />

ii<br />

Source: Collagen Research Institute (CRI), data on file.<br />

Well, the mechanisms of the adaptive immune system are regulated<br />

by cells and organs in the body, including the bone marrow – from<br />

which all cells of the immune system originate. In other words: the<br />

dynamic relationship between collagen-rich tissues and the immune<br />

response is also shown by the cross-regulation between bone health<br />

and the immune system. Bone cells, which were previously thought<br />

to only regulate each other and remodel the structural bone collagen<br />

matrix, have now also been shown to regulate immune cells. As we<br />

For more information, please visit<br />

www.immupept.com<br />

20 No. 2 August/September <strong>2021</strong>

Immune health<br />

Photo © : iStock/Ridofranz<br />

WEISHARDT, a relevant player<br />

in immune health<br />

Dr. Christelle Bonnet<br />

In 2020, the immune health supplements<br />

market size was USD 18.22<br />

billion. It is now projected to reach<br />

USD 31.50 billion by 2028, with<br />

a CAGR of 6.6 % during the forecast<br />

period (source: Fortune Business<br />

Insights). COVID-19 pandemic sparked<br />

the demand for immune health supplements<br />

across the globe. This growth is<br />

attributable to the rising reconsideration<br />

of health and well-being by the<br />

masses.<br />

Inflammation and immunity<br />

Considering the immune health, inflammation<br />

is a vital part of the immune system’s<br />

response to infection from bacteria, viruses,<br />

toxic compounds, or irradiation [1] and acts<br />

by removing injurious stimuli and initiating<br />

the healing process [2]. Inflammation is therefore a defense mechanism<br />

that is essential to the immune health [3]. Usually, during acute<br />

inflammatory responses, cellular and molecular events and interactions<br />

efficiently minimize impending injury or infection. This process<br />

contributes to restoration of tissue homeostasis and resolution of the<br />

acute inflammation. However, uncontrolled acute inflammation may<br />

become chronic and deleterious for the organism [4].<br />

In terms of pathways, these inflammatory stimuli activate intracellular<br />

signaling pathways that activate production of inflammatory mediators<br />

such as cytokines [5]. Table 1 summarizes the cytokines and<br />

their functions (pro or anti-inflammatory).<br />

Scientific studies show that NATICOL ® downregulates proinflammatory<br />

cytokines (TNF-α, IL-1β, IL-6) and increases<br />

anti-inflammatory cytokines (TGF-β, IL-10).<br />

NATICOL ® , natural fish collagen peptides developed from WEISHARDT<br />

innovative collagen science, has preclinically demonstrated its ability<br />

to resolve inflammation – the innate reaction to preserve the immune<br />

No. 2 August/September <strong>2021</strong><br />


Immune health<br />

Cytokine Family Main sources Function<br />

IL-1β IL-1 Macrophages, monocytes Pro-inflammation, proliferation, apoptosis, differentiation<br />

IL-4 IL-4 Th-cells Anti-inflammation, T-cell and B-cell proliferation,<br />

B-cell differentiation<br />

IL-6 IL-6 Macrophages, T-cells, adipocyte Pro-inflammation, differentiation, cytokine production<br />

IL-8 CXC Macrophages, epithelial cells, endothelial<br />

cells<br />

Table 1: Summary of cytokines and their functions<br />

Pro-inlammation, chemotaxis, angiogenesis<br />

IL-10 IL-10 Monocytes, T-cells, B-cells Anti-inflammation, inhibition of the pro-inflammatory cytokines<br />

IL-12 IL-12 Dendritic cells, macrophages,<br />

neutrophils<br />

Pro-inflammation, cell differentiation, activates NK cell<br />

IL-11 IL-6 Fibroblasts, neurons, epithelial cells Anti-inflammation, differentiation, induces acute phase protein<br />

TNF-α TNF Macrophages, NK cells, CD4 + lymphocytes,<br />

adipocyte<br />

Pro-inflammation, cytokine production, cell proliferation,<br />

apoptosis, anti-infection<br />

IFN-γ INF T-cells, NK cells, NKT cells Pro-inflammation, innate, adaptive immunity anti-viral<br />

GM-CSF IL-4 T-cells, macrophages, fibroblasts Pro-inflammation, macrophage activation, increase neutrophil<br />

and monocyte function<br />

TGF-β TGF Macrophages, T-cells Anti-inflammation, inhibition of pro-inflammatory cytokine<br />

production<br />

system. Indeed, in vivo study results showed that a colonic inflammation<br />

in NATICOL ® -treated DSS mice was associated with lower levels<br />

of TNF-α, IL-1β and IL-6 pro-inflammatory cytokines. The attenuated<br />

inflammation by NATICOL ® treatment was<br />

also supported by induced TGFβ and IL-10<br />

anti-inflammatory cytokines secretion.<br />

®<br />

Figures 1– Model of DSS-induced intestinal inflammation - TNF-α, IL-6, IL-1β, TGF-β and IL-10 protein levels in the colon were<br />

determined at 8 days in the colons of control or DSS-exposed mice treated or not with NATICOL ® . (n=18 per group). *p≤0.05,<br />

**p≤0.01, ***p≤0.005 compared to DSS-exposed untreated mice.<br />

22 No. 2 August/September <strong>2021</strong>

Immune health<br />

“NATICOL ® Mix Immune”/“NATICOL ®<br />

Mix Immune +”, an innovative range<br />

of nutraceutical powder systems for<br />

immune health<br />

Due to the growing interest and demand<br />

of consumers for immune health solutions,<br />

WEISHARDT has developed a range of<br />

nutraceutical complexes under the name<br />

“NATICOL ® Mix Immune” and “NATICOL ®<br />

Mix Immune +”. Formulated with NATICOL ®<br />

as the main active ingredient, these powder<br />

complexes contain vitamin C (100 % RDA)<br />

– which contributes to the protection of cell<br />

constituents from oxidative damage, reduction<br />

of tiredness and fatigue, normal function<br />

of the immune system (EFSA claims) –<br />

and/or minerals such as Copper (30 % RDA)<br />

and Zinc (70 % RDA) also contributing to<br />

the normal function of the immune health<br />

(EFSA claims). Providing established immunity<br />

solutions with vitamins and minerals<br />

but also innovative solutions with NATICOL ®<br />

which showed anti-inflammatory benefits<br />

in preclinical studies (see figure above), these stable nutraceutical<br />

complexes will help you make your entrance in the Immune market<br />

segment.<br />

WEISHARDT products are not intended to diagnose, treat, cure, or<br />

prevent any disease.<br />

References<br />

1. Medzhitov R. Inflammation 2010: new adventures of an old flame. Cell. 2010;140:771–<br />

776.<br />

2. Ferrero-Miliani L, Nielsen O, Andersen P, Girardin S. Chronic inflammation: importance<br />

of NOD2 and NALP3 in interleukin-1β generation. Clin Exp Immunol. 2007;147:227–235.<br />

3. Nathan C, Ding A. Nonresolving inflammation. Cell. 2010;140:871–882.<br />

4. Zhou Y, Hong Y, Huang H. Triptolide Attenuates Inflammatory Response in Membranous<br />

Glomerulo-Nephritis Rat via Downregulation of NF-κB Signaling Pathway. Kidney and Blood<br />

Pressure Res. 2016;41:901–910.<br />

5. Kaminska B. MAPK signalling pathways as molecular targets for anti-inflammatory<br />

therapy – from molecular mechanisms to therapeutic benefits. BBA. 2005;1754:253–262<br />

For more information, please contact<br />

WEISHARDT International<br />

81300 Graulhet, France<br />

Phone +33 5 63 42 14 41<br />

welcome@weishardt.com<br />

www.weishardt.com<br />

Expert in health ingredients and innovative formulations<br />

www.seanova.fr<br />

contact@seanova.fr +33(0)2 98 50 41 60<br />

//<br />

No. 2 August/September <strong>2021</strong><br />


Antioxidants<br />

Photo © : Helmut Pierer<br />

Astaxanthin – oxidative balance for the body<br />

Dr. Edgar Ahn, Dr. Monika Siebel<br />

What is Astaxanthin?<br />

Astaxanthin is a natural red pigment found in marine animals such<br />

as microalgae, crustaceans, fish and some birds (1), (2). Chemically,<br />

astaxanthin belongs to the carotenoid group, specifically xanthophylls,<br />

and is considered the most potent antioxidant currently known.<br />

astaxanthin under stress situations (e. g. high<br />

salt content in the water, nitrogen deficiency,<br />

high temperatures and UV light) for its own<br />

protection (4). This natural form represents<br />

the highest quality astaxanthin with the<br />

highest antioxidant potential.<br />

Despite its similar chemical structure, astaxanthin differs greatly from<br />

other carotenoids in its properties. It can cross both the blood-brain<br />

barrier and the blood-retinal barrier, thus exerting its antioxidant and<br />

anti-inflammatory protection directly on site in the brain, the nerves of<br />

the central nervous system or the retina of the eye. Astaxanthin also<br />

distributes itself extremely effectively throughout the body, so that its<br />

protective effect benefits every single cell and thus all organs, tissues,<br />

joints and skin.<br />

Astaxanthin is considered safe and has been certified by the United<br />

States Food and Drug Administration (FDA) with GRAS (generally<br />

recognized as safe) status (3).<br />

How is astaxanthin produced?<br />

Natural astaxanthin is industrially produced mainly from the green<br />

algae Haematococcus pluvialis. This alga produces the red pigment<br />

Fig. 1: Photo of the different life stages of the green alga Haematococcus<br />

pluvialis.<br />

Photo © : Helmut Pierer<br />

24 No. 2 August/September <strong>2021</strong>

Antioxidants<br />

The cultivation technologies used often differ<br />

fundamentally. In its simplest form, cultivation<br />

of the microalga takes place in open,<br />

unprotected pond systems (“open-ponds”)<br />

that use direct sunlight. However, this form<br />

of cultivation carries the risk of uncontrolled<br />

contamination by competing foreign algal<br />

strains on the one hand, and environmental<br />

pollution (e. g., contaminants from the<br />

ambient air) on the other hand. Production<br />

performance and quality often varies greatly<br />

due to climatic influences.<br />

The following factors are crucial for highquality<br />

production of natural astaxanthin<br />

from green algae:<br />

– Continuous, systematic selection of the<br />

best strains of Haematococcus pluvialis<br />

algae.<br />

– Ensuring optimal growth conditions by<br />

using the highest quality water<br />

– Cultivation in completely closed containers<br />

to meet the hygiene standards required by<br />

the food supplement industry<br />

By using suitable process technology, the<br />

living conditions for the green algae can be<br />

optimally adapted to the two different life<br />

cycles – growth phase and stress phase<br />

(see Fig. 2) – thus optimizing the yield and<br />

content of high-quality astaxanthin.<br />

In addition to algae, mostly genetically engineered<br />

bacteria or yeast fungi (Phaffia<br />

rhodozyma) can also be used for the<br />

biotechnological production of astaxanthin.<br />

Photo © : Helmut Pierer<br />

However, the astaxanthin contents obtained in these processes are<br />

much lower than in green algae (5). This astaxanthin is mainly used<br />

in fish farming as a natural colourant and is not approved for use in<br />

the food and dietary supplement (NEM) sector in Europe.<br />

Furthermore, astaxanthin can be produced from petroleum in a<br />

chemical process. This so-called synthetic astaxanthin is also not<br />

approved for use in the food and food supplement (NEM) sector in<br />

Europe. It is used purely as a colourant in the industrial breeding<br />

of fish (e. g. salmon) or other farm and domestic animals (e. g. for<br />

the specific colouring of egg yolks). Thus, when consuming industrial<br />

farmed salmon, the consumer mostly ingests only synthetic astaxanthin.<br />

Although synthetic astaxanthin has the same chemical formula as<br />

natural astaxanthin, the two forms differ substantially in their bioactive<br />

effects. Natural astaxanthin contains not only astaxanthin, but the<br />

total complex of those substances that the alga forms to ensure its<br />

survival (e. g., smaller amounts of lutein, beta-carotene, and canthaxanthin).<br />

The accompanying substances act synergistically, thus<br />

enhancing the effect of astaxanthin, making natural astaxanthin a<br />

far more effective antioxidant than synthetic astaxanthin (6). Furthermore,<br />

natural astaxanthin from green algae is in its esterified form<br />

and is therefore more stable and better adsorbed by the body.<br />

How does astaxanthin work?<br />

Fig. 2: schematic representation of the life cycles of the green alga Haematococcus<br />

pluvialis during AX production.<br />

Astaxanthin has been studied by numerous research groups worldwide<br />

and is recognized as safe and effective. The number of scientific<br />

studies on natural astaxanthin is rapidly increasing, and there is<br />

solid documentation for a variety of uses. The following health benefits<br />

of natural astaxanthin from Haematococcus pluvialis have been<br />

demonstrated in clinical studies:<br />

– Promotes healthy oxidative balance<br />

– Supports cardiovascular health<br />

– Supports healthy skin<br />

No. 2 August/September <strong>2021</strong><br />


Antioxidants<br />

– Supports healthy ageing<br />

– Supports body recovery after heavy exertion<br />

Astaxanthin and the oxidative balance<br />

Oxidative balance describes the relationship between the production<br />

of reactive oxygen species (ROS) and the activity of antioxidant<br />

protective systems. When this system is in balance, oxidative damage<br />

can be minimized and body cells can be optimally protected. Often<br />

an imbalance arises due to chronic stress, environmental pollution or<br />

heavy physical strain. Increased oxidative stress occurs, which can<br />

ultimately lead to cell damage, various diseases or premature ageing.<br />

Astaxanthin is able to restore this balance.<br />

Comparative studies have shown that the antioxidant effect of astaxanthin<br />

is much stronger than that of other compounds. For example,<br />

it has been shown to be:<br />

– 6000 times more potent than vitamin C<br />

– 770 times stronger than co-enzyme Q10<br />

– 100 times more potent than vitamin E<br />

– 55 times stronger than synthetic astaxanthin<br />

– 5 times stronger than beta-carotene<br />

– 3 times stronger than lutein<br />

– 2 times stronger than lycopene<br />

However, if inflammations turn into a chronic state, this is a sign of<br />

an imbalance in the body. The causes can be, for example, constant<br />

stress, an unfavourable diet, poor intestinal health, and always a<br />

lack of antioxidants. Chronic inflammation can cause serious tissue<br />

damage throughout the body, resulting in manifestations such as<br />

arthritis, asthma, Crohn's disease, or glaucoma.<br />

Astaxanthin has a strong anti-inflammatory effect by reducing the<br />

activity of many inflammatory messengers in the body. It can therefore<br />

be of enormous help in chronic inflammatory diseases – not as<br />

the sole remedy, of course – but as a side-effect-free component of a<br />

holistic therapy (9).<br />

Healthy ageing thanks to astaxanthin<br />

The human ageing process is accompanied by damage to the energy<br />

supply centres in our cells (mitochondria), increased production of<br />

oxidative stress and less active cell protection systems. Characteris tic<br />

age-related side effects are decreasing elasticity of the skin,<br />

slackening of muscles, eye diseases and the feeling of fatigue as well<br />

as lower performance.<br />

Numerous studies have shown that antioxi dants such as astaxanthin<br />

can slow down all these ageing processes by eliminating free radicals<br />

(10), (11), (12), (13). Often a combination of astaxanthin with<br />

various nutrients and vital substances has been administered here<br />

(e. g. omega 3, vitamin C and also vitamin E).<br />

Protection of the cardiovascular system by astaxanthin<br />

Cardiovascular diseases cause almost half of all deaths in the European<br />

Union. Chronic inflammatory processes and increased oxidative<br />

stress are significantly involved in the pathophysiological process<br />

of cardiovascular disease and atherosclerosis. The cardio protective<br />

effects of astaxanthin with its unique chemical properties have been<br />

studied for some time (14).<br />

Its chemical structure enables astaxanthin to scavenge different<br />

types of free radicals. In this regard, it is considered a “gentle” antioxidant<br />

because, compared to other antioxidants, the molecule itself<br />

does not become a highly reactive compound after absorbing a free<br />

radical (7), (8).<br />

Anti-inflammatory astaxanthin<br />

Photo © : Shutterstock<br />

Acute inflammations are crucial components of a healing process.<br />

They are an important indicator that our immune system is currently<br />

fighting a “troublemaker”, which should eventually lead back to<br />

recovery.<br />

Evidence on the cardio protective potential of astaxanthin is provided<br />

by a clinical RCT study published in 2018. Here, an eight-week intervention<br />

with 8 mg astaxanthin/day was conducted with diabetic<br />

patients. Of particular note were the significant astaxanthin-induced<br />

reductions in total fat mass and triglyceride levels. At the same time,<br />

blood pressure and VLDL levels decreased compared with placebo<br />

(15).<br />

Effects of astaxanthin on athletic performance and<br />

regeneration<br />

Intense periods of training and competition are associated with<br />

increased production of oxidative and nitrosative stress (ROS and<br />

NOS). These can damage protein, lipid and other body structures.<br />

The complex interaction of antioxidant systems usually ensures that<br />

this damage is greatly reduced or prevented. However, if the training<br />

26 No. 2 August/September <strong>2021</strong>

Antioxidants<br />

load is too high over a longer period of time, a dysbalance occurs and<br />

the production of reactive oxygen species predominates. This imbalance<br />

can also be aggravated by psychological factors (e.g. stress<br />

in work and private life), which is particularly relevant for amateur<br />

athletes. To counteract these adverse effects, the targeted use of antioxidant<br />

nutrients has become established in popular and competitive<br />

sports.<br />

Studies have shown that astaxanthin can reduce lactate levels in<br />

muscles (16). Lactate (lactic acid) is known to be an undesirable<br />

product that can be produced in the muscles during physical exertion,<br />

causing fatigue and a burning sensation. If one wants to enjoy<br />

athletic success, lactate levels should be kept as low as possible.<br />

Problems that can arise from excessive strain during sports can<br />

also be remedied more quickly with astaxanthin. In the case of the<br />

so-called “tennis elbow”, for example, it is an inflammation of the<br />

tendons or tendon attachments at the elbow. In one study, a significantly<br />

faster reduction in the symptoms of tennis elbow was observed<br />

after taking astaxanthin (17).<br />

Miracle weapon astaxanthin?<br />

It often seems unbelievable when such a variety of possible effects<br />

are listed in connection with natural active ingredients such as astaxanthin.<br />

How should one and the same substance be able to help<br />

with such different ailments as eye complaints, joint pain, cardiovascular<br />

problems, sunburn, etc.? The explanation lies in the fact that<br />

many diseases have different symptoms but one and the same cause<br />

– oxidative stress and/or inflammation.<br />

Our joints, our organs, our senses – they are all made up of tiny cells<br />

that are very similar in function and therefore all react negatively to<br />

oxidative stress, and are threatened by inflammation. Therefore, it is<br />

a logical conclusion that all of our cells respond positively to a protective<br />

substance that can reduce and/or eliminate oxidative stress and<br />

inflammation – astaxanthin!<br />

About BDI-BioLife Science<br />

BDI-BioLife Science is a specialist in the development of innovative<br />

technologies for the production of high quality algae valuables<br />

for the LifeScience industry.<br />

References<br />

1. Guerin, M et al.; Haematococcus astaxanthin: applications for human health and nutrition;<br />

Trends Biotechnol (2003) 21(5):210–6.<br />

2. Hussein, G. et al.; Astaxanthin, a carotenoid with potential in human health and nutrition;<br />

J Nat Prod (2006) 69(3):443–9.<br />

3. Fuji Chemical Industry Co., Ltd.; Notification of GRAS Determination for Haematococcus<br />

pluvialis extract characterized by component astaxanthin esters (of common edible fatty<br />

acids); (2009).<br />

4. Ambati, R. R. et al.; Astaxanthin: sources, extraction, stability, biological activities and<br />

its commercial applications – a review; Mar Drugs. (2014) 12(1):128–52.<br />

5. Dominguez-Bocanegra, A.R. et al.; Astaxanthin production by Phaffia rhodozyma and<br />

Haematococcus pluvialis: a comparative study; Appl Microbiol Biotechnol (2007) 75:783-<br />

791.<br />

6. Novoveská, L.; Microalgal Carotinoids: a review of production, current markets, regulations<br />

and future direction; Mar. Drugs (2019) 17:640<br />

7. Nishida, Y. et al.; Quenching Activities of Common Hydrophilic and Lipophilic Antioxidants<br />

against Singlet Oxygen Using Chemiluminescence Detection System; Carotenoid Sci.<br />

(2007) 11:16–20.<br />

8. Beutner, S. et al.; Quantitative assessment of antioxidant properties of natural colorants<br />

and phytochemicals: carotenoids, flavonoids, phenols and indigoids. The role of β-carotene<br />

in antioxidant functions; J Sci Food Agric. (2001) 81(6):559–68.<br />

9. Underwood, A.; Quieting a Bodys Defenses; Newsweek Magazine, Special Summer Issue,<br />

August 2005. Pg. 26-28.<br />

10. Tominaga, K. et al.; Cosmetic benefts of astaxanthin on human subjects; Acta Biochim<br />

Pol. (2012) 59(1):43–7.<br />

11. Ito, N. et al.; The Protective Role of Astaxanthin for UV-Induced Skin Deterioration in<br />

Healthy People – A Randomized, Double-Blind, Placebo-Controlled Trial; Nutrients (2018)<br />

pii: E817.<br />

12. Kim, Y. K. et al.; The effects of astaxanthin supplements on lipid peroxidation and antioxidant<br />

status in postmenopausal women; Nutr Sci. (2004) 7(1):41–6.<br />

13. Kajita, M. et al.; The Effects of a Dietary Supplement Containing Astaxanthin on the<br />

Accommodation Function of the Eye in Middle-aged and Older People; Med Consult N<br />

Remed. (2009) 46(3):89–93.<br />

14. Visioli, F. et al.; Astaxanthin in cardiovascular health and disease: mechanisms of<br />

action, therapeutic merits, and knowledge gaps; Food Funct. (2017) 8(1):39–63.<br />

15. Mashhadi, N. S. et al.; Astaxanthin improves glucose metabolism and reduces blood<br />

pressure in patients with type 2 diabetes mellitus; Asia Pac J Clin Nutr. (2018) 27(2):341–6.<br />

16. Sawaki, K., et al.; Sports Performance Benefits from Taking Natural Astaxanthin Characterized<br />

by Visual Acuity and Muscle Fatigue Improvements in Humans; Journal of Clinical<br />

Therapeutics & Medicines (2002) 18:(9)73-88.<br />

17. Spiller, G., et al.; Effect of daily use of natural astaxanthin on symptoms associated<br />

with Tennis Elbow (lateral humeral epicondylitis); On file at Cyanotech Corporation (2006)<br />

For more information, please contact<br />

Dr. Edgar Ahn,<br />

Chief Innovation Officer of the parent<br />

company of BDI-BioLife Science<br />

Dr. Monika Siebel,<br />

Sales Director Nutrition & Pharma<br />

of BDI-BioLife Science<br />

www.bdi-biolifescience.com<br />

In the cultivation plant located in the Ökopark Hartberg/Austria,<br />

BDI-BioLife Science produces natural astaxanthin tailor-made<br />

for the cosmetics (AstaCos ® ) and dietary supplements (AstaFit ® )<br />

industry using the closed algae cultivation process developed<br />

in-house.<br />

No. 2 August/September <strong>2021</strong><br />


Marine oils<br />

Photo © : Calanus<br />

Seanova – a major player in the<br />

food supplements business<br />

Located in Finistère, Brittany, Seanova is as close as possible to the<br />

ocean and its wonders. The company, which now has 17 employees,<br />

was born out of a man's passion for marine biotechnology and health<br />

nutrition. Seanova’s main goal was the enhancement of marine and<br />

plant lipids.<br />

The blend the employees’ various skills makes it possible to support<br />

customers in the development of their projects, their formulations<br />

and to offer personalized solutions. Efficiency, innovation and respect<br />

for the environment are at the core of the company.<br />

The origin of Seanova<br />

After graduating in oceanography and marine biology, Stéphane<br />

Lozachmeur, its founder, began his career in a scientific research<br />

center in order to study the micro-nutrition of fish larvae. While the<br />

impact of nutrients and their quality on the development and on the<br />

animal health is very important, the entrepreneur quickly understood<br />

that humans require nutrients of very high quality. It is on these bases<br />

that the Seanova’s adventure began in 1994,<br />

in Brittany, in order to offer the most stable,<br />

the purest and the most natural marine<br />

ingredients.<br />

The marine environment is a source of wellbeing<br />

for humans. From the start, Seanova<br />

recognized the potential of oils naturally rich<br />

in omega-3 fatty acids. Thanks to the infinite<br />

richness of the oceans, the French company<br />

started to specialize in the enhancement of<br />

lipids and marine actives.<br />

Fully in line with the demand for naturality<br />

expected by consumers, Seanova carefully<br />

selected marine active ingredients that<br />

were perfectly answering the needs of the<br />

constantly growing health & and well-being<br />

market.<br />

28 No. 2 August/September <strong>2021</strong>

Marine oils<br />

Aware of nutrition and health issues, the<br />

Breton team is working to offer a range of<br />

marine oils highly concentrated in omega-3<br />

Docosahexaenoic acid (DHA) and Eicosapentaenoic<br />

acid (EPA).<br />

It also offers vegetable oils rich in omega 3<br />

and omega 6 (hemp, chia, borage, evening<br />

primrose). The company uses eco-certified<br />

resources, always with a desire to preserve<br />

the environment.<br />

Seanova oils benefit from superior stability,<br />

thanks to the patented XO ® process. It is an<br />

enrichment in natural antioxidants, such as<br />

rosemary, which preserves the nutritional<br />

and organoleptic qualities as well as the shelf<br />

life of oils (marine and vegetable).<br />

The company’s core business is to offer<br />

inno vative formulations from the sea and<br />

plants. They formulate oils, capsules,<br />

powders, microcapsules for their customers<br />

specialized in nutraceuticals, agrifood and<br />

veterinary products.<br />

Epax ® is a world leader in concentrated omega-3 fatty acids. Using<br />

high quality, sustainable and traceable raw materials only, Epax ®<br />

provides scientifically proven, health specific, safe and pure omega-3<br />

formulas.<br />

The oils come from small wild blue fish (like herring, anchovies, tuna,<br />

mackerel, sardines) caught along the cold waters of the Chilean and<br />

Peruvian coasts. The sustainability of natural resources requires strict<br />

compliance with quotas. These quotas are licensed by the Chilean<br />

and Peruvian governments. Fishing is limited to two catches per year<br />

and is interrupted during the fish breeding season. Preferred species<br />

are fish with a rapid reproduction cycle (from 2 to 3 years) and a high<br />

fertility rate.<br />

Epax’ commitment: Purity, Quality, Innovation – The best omega-3<br />

fatty acids EPA/DHA ingredients on the market<br />

Calanus ® /Zooca ® : As a pioneer, Zooca ® is developing a new bioindustry<br />

based on the marine copepod Calanus Finmarchicus, one<br />

of the largest renewable and exploitable resources on the planet.<br />

Zooca ® has developed a patented fishing technology, which allows<br />

responsible fishing, with a minimum of bycatch.<br />

Photo © : Seanova<br />

High quality partners<br />

Seanova can rely on the high quality of its<br />

partners to perform and maintain a upmost<br />

level of standards in terms of quality, efficiency,<br />

responsibility and sustainable development.<br />

A long-term strategic alliance with its<br />

suppliers guarantees full traceability from<br />

source to finished ingredients. Preserving<br />

the resources and well-being of the oceans<br />

begins with choosing the best quality and<br />

having real ethics.<br />

The traceability of raw materials must be<br />

perfect. The raw materials must come<br />

from the revaluation of fishing to avoid the<br />

problems of wasting resources. They must<br />

respect the reproduction cycles of species in<br />

order to guarantee their sustainability.<br />

The company has partnered with the leaders<br />

of marine ingredients. These partners use<br />

certified eco-responsible fishing techniques<br />

that respect the environment (no by-catch of<br />

species such as dolphins, whales, etc.).<br />

No. 2 August/September <strong>2021</strong>

Marine oils<br />

By conscientiously promoting marine biodiversity,<br />

Seanova aims to minimize the impact<br />

of humans on the marine environment.<br />

Seanova supports several ambitious projects<br />

for the protection of marine environments,<br />

the repopulation of the oceans and the restoration<br />

of the biodiversity of coastal reefs:<br />

Iodysséus: Seanova joined the Iodysséus<br />

adventure in 2019. The program called<br />

“Objectif bloom”, launched by skipper Eric<br />

Defert, is unique. This is an offshore race, in<br />

a trimaran, 100 % dedicated to performance<br />

and scientific research on marine aerosols.<br />

Photo © : Calanus<br />

With the Novel Food status obtained in 2017, this oil differs from that<br />

of fish and krill by its biomedical effects and its unique composition.<br />

Zooca ® Oil has been shown (clinical studies and supporting scientific<br />

literature) to have beneficial properties in preventing widespread<br />

health issues associated with an unhealthy Western lifestyle.<br />

AkerBiomarine ® : Specialist in products derived from krill,<br />

AkerBioMarine ® uses ecological harvesting technology (Eco-<br />

Harvesting ® ) to maintain the nutritional integrity of these crustaceans<br />

and minimize the environmental impact. Their krill oil is certified ecoresponsible<br />

by the Marine Stewarship Council (MSC) and received<br />

an exceptional A rating 6 years in a row by SFP (Sustainable Fishery<br />

Partnership).<br />

It is the sole krill supplier who controls the entire harvesting and<br />

production process, from sea to capsule. AkerBioMarine ® thus offers<br />

high quality ingredients with a high content of healthy active ingredients:<br />

phospholipids, omega-3 fatty acids, choline and astaxanthin. In<br />

2020, Seanova developed a new strategic partnership with Algamo.<br />

Algamo: Established in 2011, Algamo is a specialist in the cultivation<br />

of algae and in the extraction of astaxanthin. The only producer in<br />

Central Europe, Algamo has chosen to settle in a mountainous region,<br />

which is a perfect place to ensure the production of ecologi cal, 100 %<br />

pure and excellent quality astaxanthin. This astaxanthin extracted<br />

from Haematococcus Pluvialis is grown and produced in Europe and<br />

has the EU organic certification. It is unique. This partnership allows<br />

Seanova to expand its plant-based, certified organic product range.<br />

The program consists of collecting data on<br />

the health of the seas and oceans by study ing<br />

the spring bloom of the North Atlantic, i. e.<br />

the seasonal efflorescence of photosynthetic<br />

microalgae that absorb, globally on a planetary<br />

scale, a third of the excess CO 2<br />

emitted<br />

in the atmosphere and producing 50 % of<br />

the oxygen essential to life.<br />

Iodysséus brings to land a rich palette of<br />

microbiological samples taken in vivo in<br />

marine aerosols under real conditions of<br />

rough seas. Those samples are likely to help<br />

increase the knowledge about the partnership<br />

between the ocean and the climate,<br />

in a context marked today by urgency. The<br />

Iodysséus program has just been recognized<br />

by the United Nations as an ocean science<br />

program for sustainable development.<br />

Nurseries for young fish: It is the study of<br />

species and their environment: supported<br />

by the founder of Seanova, Stéphane<br />

Lozachmeur, this project aims to make<br />

existing port infrastructures biocompatible.<br />

Very close to Seanova's, the port of Bénodet,<br />

in southern Finistère, was in 2018 the first<br />

Protection of marine environments<br />

The impact of humans is can be seen in the whole food chain, starting<br />

in the ocean. Oceans regenerate naturally. The key to sustainability is<br />

to ensure that we are not depleting our ocean's resources faster than<br />

they can be replenished.<br />

30 No. 2 August/September <strong>2021</strong>

Marine oils<br />

port on the Atlantic coast to be equipped<br />

with such a device.<br />

Seanova supported the Ecocean company,<br />

which created the Biohut ® , artificial nur series<br />

for young fish. In the form of steel modules<br />

filled with oyster shells, the Biohut ® are<br />

suspended under the pontoons and become<br />

oases of life among pleasure boats.<br />

Strong bones<br />

for life!<br />

Thanks to the different types of existing artificial<br />

nurseries, the quays, dikes, pontoons, as<br />

well as all the coastal facilities become real<br />

refuges for many aquatic species. The ports<br />

thus contribute to the improvement of biodiversity<br />

within their environment.<br />

Mother Of the Sea: In order to go further in<br />

its commitment towards the environment,<br />

Seanova sponsors an association called<br />

Mother of the Sea.<br />

Its mission is to collect the eggs of wild fish<br />

species (such as sea bass, place, sole, etc.),<br />

to fertilize them with wild spawners, then<br />

to protect them in seawater pools for about<br />

7 weeks. The juveniles are then released<br />

at sea.<br />

“We are thus promoting the survival rate,<br />

which drops from 0.2 % in the natural environment<br />

to 20 % thanks to Mother of the Sea.<br />

In other words, out of 1 million eggs, 200,000<br />

will reach sexual maturity thanks to MOS,<br />

instead of 2,000. We are really committed to<br />

taking advantage of the science of contemporary<br />

aquaculture to develop the restoration<br />

of the natural environment that so exploited!<br />

As a first-rate actor for the preservation of<br />

the marine environment, we have a message<br />

of hope for the younger generations and<br />

wish to show them that we can act in order<br />

to develop a positive impact on marine<br />

ecology”, specifies the founder of Seanova.<br />

Seanova's ambition: to be an actor involved<br />

in marine ecology.<br />

For more information, please contact<br />

Stéphane LOZACHMEUR<br />

contact@seanova.fr<br />


7 chemin de Kilourin 29170 Pleuven, France<br />

www.seanova.fr<br />

Osteum is a brand of Ingredia<br />

No. 2 August/September <strong>2021</strong><br />


Skin health<br />

Groundbreaking new study shows<br />

Pycnogenol ® may help retain skin moisture<br />

and elasticity, increase skin lightening,<br />

and reinforce skin barrier function<br />

New published research builds on decades of established science demonstrating extensive benefits of<br />

Pycnogenol ® , a natural antioxidant for skin health<br />

Just in time for summer, researchers have found how the<br />

natural super-antioxidant Pycnogenol ® can safeguard your<br />

skin from seasonal changes and environmental stress. A<br />

new peer reviewed, randomized, double-blind, placebocontrolled<br />

crossover study shows that daily supplementation<br />

with Pycnogenol ® French maritime pine bark extract may<br />

help to significantly retain skin hydration, increase skin elasticity,<br />

and reinforce skin barrier function for those exposed to<br />

urban environmental pollution, as well as seasonal temperature<br />

and humidity variations. In addition, the study found<br />

Pycnogenol ® to increase skin lightening during seasonal<br />

changes when dark spots can emerge.<br />

“So many of us are awaiting this summer to truly enjoy the outdoors<br />

after a brutal winter and a long pandemic year. I personally cannot<br />

wait to be outside, and that means we have<br />

to be proactive in protecting our skin from<br />

heat, humidity, solar radiation, and pollution,”<br />

says renowned natural health physician<br />

and author, Dr. Fred Pescatore. “This<br />

new study shows that daily supplementation<br />

with Pycnogenol ® counteracts damaging<br />

environmental stress factors and improves<br />

skin barrier function, even when exposed to<br />

rigid conditions.”<br />

Published in Skin Pharmacology Physiology,<br />

this study tested 76 participants, 57 of whom<br />

were women, with an average age of 41. The<br />

test group was comprised of workers who<br />

32 No. 2 August/September <strong>2021</strong>

Skin health<br />

spent long hours outdoors in Beijing, China<br />

and were exposed to urban air pollution and<br />

environmental stress as well as seasonal<br />

changes in temperature and humidity from<br />

April to November. Two groups were tested<br />

in the study: a verum and a placebo group.<br />

During the first 12 weeks, from April to July,<br />

the rainy season, the verum group supplemented<br />

orally with 100 mg of Pycnogenol ®<br />

daily. After a 1-week washout period, participants<br />

were crossed over from verum to<br />

placebo and vice versa for another 12-week<br />

study phase of a dry autumn period.<br />

Researchers measured the skin moisture<br />

content of the participants with the Corneometer<br />

® skin moisture tester. Transepidermal<br />

water loss (TEWL) was measured with the<br />

Tewameter ® , and skin elasticity was measured<br />

with the Cutometer ® .<br />

Results showed that daily oral supplementation with 100 mg of<br />

Pycnogenol ® for 12 weeks from April to July, during the wet season,<br />

provided a striking improvement of significant skin concerns,<br />

including:<br />

– 7 % improvement in skin elasticity<br />

(vs 1 % increase in the placebo group)<br />

– 7 % improvement in skin firmness<br />

(vs 3 % decrease in the placebo group)<br />

Additionally, during phase 2, from July to October, during the dry<br />

season, daily oral supplementation with 100 mg of Pycnogenol ®<br />

showed:<br />

– 13.8 % increase in skin lightening<br />

(vs 0.8 % decrease in the placebo group)<br />

– 14 % decreased in transepidermal water<br />

loss (TEWL), indicating a significant<br />

improvement of skin barrier function<br />

(vs 4.5 % increase in the placebo group)<br />

– 3.3 % decrease of skin moisture<br />

(vs 14 % decrease in the placebo group)<br />

– 13 % improvement in skin elasticity<br />

(vs 7 % increase in the placebo group)<br />

– 13 % improvement in skin firmness<br />

(vs 3 % increase in the placebo group)<br />

This corroborates with previous research that has shown<br />

Pycnogenol ® ’s unique ability to promote collagen and hyaluronic acid<br />

production within the skin. Indeed, in a clini cal study Pycnogenol ®<br />

revealed increased hyaluronic acid synthase levels by 44 %. The<br />

hyaluronic acid synthase is the natural source of water-binding hyaluronic<br />

acid in the dermis.<br />

No. 2 August/September <strong>2021</strong><br />


Skin health<br />

This study builds on a body of clini cal research<br />

supporting the benefits of Pycnogenol ® as<br />

a natural anti-inflammatory and antioxidative<br />

ingredient. To review clinical research<br />

and additional information on Pycnogenol ® ,<br />

visit www.pycnogenol.com. Pycnogenol ® is<br />

available in more than 1,000 dietary supplements<br />

and health products worldwide.<br />

“Pycnogenol ® has a deep catalog of research for skin health, and<br />

this study builds upon decades of existing science to show that oral<br />

supplementation with Pycnogenol ® can make a significant difference<br />

in skin health and appearance, even in strenuous environmental<br />

conditions,” said Dr. Pescatore.<br />

In the study, researchers concluded that this research “strongly indicates<br />

that people exposed to high levels of environmental stress will<br />

benefit from the regular intake of Pycnogenol ® .” The authors propose<br />

that oral intake of Pycnogenol ® may represent one easy-to-use<br />

strategy, which can be used to benefit the human skin in individuals<br />

living in an urban environment.<br />

“As a doctor, I routinely have conversations with patients about the<br />

importance of protecting their skin year-round. I regularly recommend<br />

Pycnogenol ® and this study reinforces why,” says Dr. Pescatore.<br />

About Pycnogenol ®<br />

Pycnogenol ® is a natural plant extract originating from the bark of the<br />

maritime pine that grows along the coast of southwest France and<br />

is found to contain a unique combination of procyanidins, bioflavonoids<br />

and phenolic acids, which offer extensive natural health benefits.<br />

The extract has been widely studied for the past 40 years and<br />

has more than 450 published studies and review articles ensuring<br />

safety and efficacy as an ingredient. Today, Pycno genol ® is available<br />

in more than 1,000 dietary supplements and health pro ducts worldwide.<br />

For more information, visit www.pycnogenol.com.<br />

About Horphag Research<br />

Horphag Research is the exclusive worldwide distributor for<br />

Pycnogenol ® (pic-noj-en-all) brand French maritime pine bark<br />

extract. Pycnogenol ® is a registered trademark of Horphag Research.<br />

For its patented ingredient, Pycnogenol ® , Horphag Research has<br />

been awarded the Frost & Sullivan Excellence in Research Award,<br />

Nutraceutical Business & Technology Safety & Quality Award,<br />

SupplySide West Scientific Excellence Award and The American<br />

Botanical Council’s Tyler Research Award. Horphag Research has<br />

the exclusive rights to market and sell Pycnogenol ® worldwide and<br />

benefits from more than 40 years of scientific research assuring the<br />

safety and efficacy of Pycnogenol ® as a dietary supplement.<br />

For more information, please visit<br />

www.pycnogenol.com<br />

Impressum<br />

ISSN 2364-8104<br />

<strong>Wellness</strong> <strong>Foods</strong> & <strong>Supplements</strong> | No. 2/<strong>2021</strong><br />

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34 No. 2 August/September <strong>2021</strong>

Technology & Marketing<br />

International Magazine June 2020 ISSN 2628-5851<br />

International Magazine October 2019 ISSN 2628-5851<br />

International Magazine April 2020 ISSN 2628-5851<br />

2/20<br />

Technology & Marketing<br />

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xxx<br />

1/20<br />

Ingredients: Hydrocolloids in Pet Food, Acacia Gum's Versatility, Antioxidants<br />

Processing: Optical Sorting, Gentle Cooling, Removing Risks in Food Safety<br />

Packaging: Pouches and Printing, Sustainability, Choosing the Right Bags<br />

Marketing: Ask the Vet, Company News, Updates From the Fairs<br />

Ingredients Blueberries, Fiber, Seafood, Microencapsulation<br />

Processing Extrusion, Pumping and Dosing, Pellet Production<br />

Packaging Flexible Wet Packaging and Sleeving, Pouches for Treats<br />

Marketing<br />

Showcase India, Interzoo 2020 Preview<br />

Ingredients Indispensable Fatty Acids, Dietary Fiber for Pets, Yeast<br />

Processing HPP Technology, Extruding Fish Feed, Encapsulation<br />

Packaging Canning, Recyclable Bags, Cartons<br />

Marketing The Vet's Corner, News from Fairs and Firms<br />

FREE trial issue at food@harnisch.com<br />

The magazine PetFood PRO has grown out of a conviction and wish to<br />

underline the high level of quality and care in the manufacture of pet food,<br />

through the choice of ingredients, choice of technology and choice of<br />

packaging materials. We will endeavour to present this in an informative way,<br />

through a reader-friendly style and with a marketing perspective.<br />


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