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College Publications 2005-06 2005 Division of Medicinal Chemistry and Pharmacognosy J.C. Hackett, R.W. Brueggemeier, and C.M. Haddad, The final catalytic step of cytochrome P450 aromatase: A density functional theory study. J. Am. Chem. Soc., 127, 5224-5237 (2005). E.S. Diaz-Cruz, C.L. Shapiro, and R.W. Brueggemeier, Cyclooxygenase inhibitors suppress aromatase expression and activity in breast cancer cells. J. Clin. Endocrinol. Metab., 90, 2563-2570 (2005). R.W. Brueggemeier, J.C. Hackett, and E.S. Diaz-Cruz, Aromatase Inhibitors for the Treatment of Breast Cancer. Endocrine Reviews, 26, 331-345 (2005). J.C Hackett, Y.-W. Kim, B. Su, and R.W. Brueggemeier, Synthesis and characterization of azole isoflavone inhibitors of aromatase. Bioorg. Med. Chem., 13, 4063-4070 (2005). R.W. Brueggemeier, E.S. Díaz-Cruz, P.-K. Li, Y. Sugimoto, Y.C. Lin, C.L. Shapiro, Translational studies on aromatase, cyclooxygenases, and enzyme inhibitors in breast cancer. J. Steroid Biochem. Molec. Biol., 95, 129-136 (2005). B. Su, J.C Hackett, E.S. Díaz-Cruz, Y.-W. Kim, and R.W. Brueggemeier, Lead optimization of 7-benzyloxy 2- (4’-pyridylmethylthio) isoflavone aromatase inhibitors. Bioorg. Med. Chem., 13, 6571-6577 (2005). R.W. Brueggemeier, “Sex Hormones (Male), Analogs, and Antagonists” in Encyclopedia of Molecular Cell Biology and Molecular Medicine, Volume 13, R.A. Meyers, Editor-in-Chief, Wiley-VCH Verlag GmbH & Co., Weinheim, Germany, 1-69, 2005. J.-W. Huang, C.-W. Shiau, Y.-T. Yang, K.-F. Chen, S. K. Kulp, R. W. Brueggemeier, C. L. Shapiro, and C.-S. Chen (2005) “Peroxisome Proliferator-Activated Receptor g-Independent Ablation of Cyclin D1 by Thiazolidenediones and Their Derivatives in Breast Cancer Cells” Mol Pharmacol, 67, 1342-1348 A. J. Johnson, L. L. Smith, J. Zhu, N. A., Heerema, S. Jefferson, M. R. Grever, C.-S. Chen, J. C. Byrd (2005) “A novel celecoxib derivative inducesapoptosis in primary CLL cells and transformed B-cll lymphoma via a caspaseand Bcl-2-independent mechanism” Blood, 105, 2504-2509 H. Ding, C. Han, J. Zhu, C.-S. Chen, and S. M. D'Ambrosio (2005) “Celecoxib derivatives induce apoptosis via the disruption of mitochondrial membrane potential and activation of caspase 9” Int. J. Cancer, 113, 803-810. C.-W. Shiau, C.-C. Yang, K.-F. Chen, J.-W. Huang, and C.-S. Chen (2005) “Thiazolidenediones mediates apoptosis in prostate cancer cells, in part, via the inhibition of Bcl-xL/Bcl-2 functions independently of PPARg” Cancer Res., 65, 1561-1569. P.-H. Tseng, H.-P. Lin, K.-F. Chen, J. Zhu, J.C C. Byrd, M. R. Grever, B. J. Druker, and C.-S. Chen (2005) “synergistic interactions between imatinib and the novel phosphoinositide-dependent kinase-1 inhibitor OSU- 03012 in overcoming imatinib resistance” Blood, 105, 4021-4027. O.S. Gardner, C.-W. Shiau, C.-S. Chen, and L.M. Graves (2005) “PPARg-independent activation of p38 MAPK by thiazolidebediones involves calcium/calmodulin-dependent protein kinase II and protein kinase R: correlation with endoplasmic reticulum stress” J. Biol. Chem., 280, 10109-10118. C,-S, Chen, S.-C. Weng, P.-H. Tseng, H.-P. Lin, and C.-S. Chen (2005) “Nonepigenetic effects of histone deacetylase inhibitors on Akt through reshuffling protein phosphatae-1 complexes” J. Biol. Chem, 280, 38879- 38887. Q. Lu, D.-S. Wang, C.-S. Chen, Y.D. Hu, and C.-S. Chen (2005) “Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors” J. Med. Chem. 48, 5530-5535. S. K. Kulp, K.-F. Chen, and C.-S. Chen (2005) “Chemotherapy for prostate cancer” in Prostate Cancer. Basic mechanisms and Therapeutic Approaches (Ed., C. Chang) World Scientific, New Jersey, pp. 365-82 J.E. Kucab, C. Lee, C.-S. Chen, J. Zhu, C. B. Gilks, M. Cheang, D. Huntsman, E. Yorida, J. Emerman, M. Pollak, S. E. Dunn (2005) Celecoxib analogues disrupt Akt signaling, which is commonly activated in primary breast tumours Breast Cancer Research 2005, 7:R796-R807 37
38 Z. Tong, X. Wu, D. Ovcharenko, J. Zhu, C.-S. Chen, J. P. Kehrer (2005) Neutrophil gelatinase associated lipocalin as a survival factor. Biochem. J. 391, 441-448 Alshafie, G.A.; Walker, J.R.; Curley, R.W., Clagett-Dame, M.; Highland, M.A.; Nieves, N.J.; Stonerock, L.A.; Abou-Issa, H., “Inhibition of Mammary Tumor Growth by a Novel Non-toxic Retinoid: Chemotherapeutic Evaluation of a C-Linked Analog of 4-HPR Glucuronide”, Anticancer Res. 2005, 25, 2391-2398. Rivero-Cruz, J. F.; Lezutekong, R.; Lobo-Echeverri, T.; Ito, A.; Mi, Q.; Chai, H.-B.; Soejarto, D. D.; Cordell, G. A.; Pezzuto, J. M.; Swanson, S. M.; Morelli, I.; Kinghorn, A. D. Cytotoxic constituents of the twigs of Simaruba glauca. Phytother. Res., 19,136-140, 2005. Lobo-Echeverri, T.; Rivero-Cruz, J. F.; Su, B.-N.; Chai, H.-B.; Cordell, G. A.; Pezzuto, J. M.; Swanson, S. M.; Soejarto, D. D.; Kinghorn, A. D. Constituents of the leaves and twigs of Calyptranthes pallens collected from an experimental plot in southern Florida. J. Nat. Prod., 68, 577-580, 2005. Lee, D.; Li, C.; Graf, T. N.; Schunke Vigo, J.; Graham, J. G.; Cabieses, F.; Farnsworth, N. R.; Cordell, G. A.; Kinghorn, A. D.; Kroll, D. J.; Wani, M. C.; Oberlies, N. H. Diterpene glycosides from Egletes viscosa. Planta Med., 71, 794-796, 2005. Jones, W. P.; Lobo-Echeverri, L.; Mi, Q.; Chai, H.; Lee, D.; Soejarto, D. D.; Cordell, G. A. Pezzuto, J. M.; Swanson, S. M.; Kinghorn, A. D. Antitumor activity of 3-chlorodeoxylapachol, a naphthoquinone from Avicennia germinans collected from an experimental plot in southern Florida. J. Pharm. Pharmacol., 57, 1001- 1008, 2005. (Special issue devoted to medicinal plants of neotropical origin). Su, B.-N., Pawlus, A. D.; Jung, H.-A.; Keller, W. J.; McLaughlin, J. L.; Kinghorn, A. D. Chemical constituents of the fruits of Morinda citrifolia (Noni) and their antioxidant activity. J. Nat. Prod. 68:592-595, 2005. Mi, Q.; Lantvit, D.; Reyes-Lim, E.; Chai, H.; Pfiher, S.S.; Wani, M.C.; Wall, M. E.; Tan, G. A.; Cordell, G. A.; Farnsworth, N. R.; Kinghorn, A. D.; Swanson, S. M. Apoptotic anticancer effect of alvaradoin E isolated from Alvaradoa haitensis. Anticancer Res., 25, 779-788, 2005. Jang, D. S.; Su, B.-N.; Pawlus, A. D.; Jones, W. P.; Kleps, R. A.; Bunyapraphatsara, N.; Fong, H. H. S.; Pezzuto, J. M.; Kinghorn, A. D. Limnophilospiroketone, a highly oxygenated phenolic derivative from Limnophila geoffrayi. J. Nat. Prod. 68, 1134-1136, 2005. Pawlus, A. D.; Su, B.-N.; Keller, W. J.; Kinghorn, A. D. An anthraquinone with potent quinone reductaseinducing activity and other constituents of the fruits of Morinda citrifolia (Noni). J. Nat. Prod. 68, 1720-1722, 2005. (Rapid communication). Kim, S; Su, B-N.; Riswan, S., Kardono, L. B. S.; Afriastini, J. J.; Gallucci, J. C.; Chai, H.; Farnsworth, N. R.; Cordell, G. A.; Swanson, S. M.; Kinghorn, A. D. Edulisones A and B, two epimeric benzo[b]oxepine derivatives from the bark of Aglaia edulis. Tetrahedron Lett. 46, 9021-9024, 2005. Li, C.; Lee, D.; Graf, T. N.; Phifer, S.S.; Nakanishi, Y.; Burgess, J. P.; Riswan, S.; Setyowati, F. M.; Saribi, A. M.; Soejarto, D. D.; Farnsworth, N. R.; Falkinham III, J. O.; Kroll, D. J.; Kinghorn A. D.; Wani, M. C.; Oberlies, N. H. A hexacyclic ent-trachylobane diterpenoid possessing an oxetane ring from Mitrephora glabra. Org. Lett., 7, 5709-5712, 2005. Pezzuto, J. M.; Kosmeder II, J. W.; Park, E.J.; Lee, S.K.; Cuendet, M.; Gills, J.; Bhat, K.; Grubhesic, S.; Park, H.-S.; Mata-Greenwood, E.; Tan, Y.; Yu, R.; Lantvit, D. D.; Kinghorn, A. D. Characterization of natural product cancer chemopreventive agents. In Cancer Chemoprevention. Vol. 2. Strategies for Cancer Chemoprevention; Kelloff, G. J., Hawk, E. T., Sigman, C. C., Eds.; Humana Press, Inc.: Totowa, NJ, 2005, pp. 3-37. Gu, J.; Kinghorn, A. D. Bioactive constituents of plants in the genus Hernandia. In Studies in Natural Products Chemistry. Vol. 30. Bioactive Natural Products (Part K); A.-ur-Rahman, Ed.; Elsevier Scientific Publications: Amsterdam, 2005, 559-602. Pawlus, A. D.; Su, B.-N.; Kinghorn, A. D. Noni (Morinda citrifolia L.). In The Encyclopedia of Dietary Supplements; Coates, P. M., Blackman, M. R., Cragg, G. M., Levine, M., Moss, M., White J. D., Eds; Marcel Dekker: New York, 2005, pp. E1-E8. (Published electronically).
Page 2 and 3: COLLEGE OF PHARMACY Dr. Robert W. B
Page 4 and 5: Vision and Mission Statements Our M
Page 6 and 7: each class is near the program capa
Page 8 and 9: completed climate assessments, cond
Page 10 and 11: Name Hometown Honors Awards Maughan
Page 12 and 13: Name Hometown Honors Awards McElroy
Page 14 and 15: Non-Traditional Doctor of Pharmacy
Page 16 and 17: Bachelor of Science in Pharmaceutic
Page 18 and 19: Name Hometown Honors Awards Holmes,
Page 20 and 21: MS and PhD Graduates in 2005: Name
Page 22 and 23: Faculty Faculty The College of Phar
Page 24 and 25: Marialice Bennett Graig Pedersen Gu
Page 26 and 27: Academic Divisions, 2005-06 Divisio
Page 28 and 29: Division of Pharmacology Wallace, L
Page 30 and 31: faculty have been important partici
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Page 34 and 35: College of Pharmacy Administrative
Page 36 and 37: Figure 6. Distribution of Research
Page 40 and 41: Jones, W. P.; Kinghorn, A. D. Extac
Page 42 and 43: Chen J, Hwang DJ, Bohl CE, Miller D
Page 44 and 45: Lee, B., Butcher, G.Q., Hoyt, K.R.,
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Page 54 and 55: LeBlanc J, Dasta JF, Kane-Gill SL.
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Page 66 and 67: James Robert Hostler Karen Kiplinge
Page 68 and 69: Dean’s Corporate Council The Dean
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