Senior Design Expo 2022

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Biomedical Engineering CAUTIcare Ozgenur Celik, Michaela O’Donnell, Neil Kennedy, Prithi Chakrapani, Emma Glajchen The most common and severe complication of indwelling catheterization is the inoculation of bacteria into the body, leading to catheter-associated urinary tract infections (CAUTIs). Patients are not regularly tested for CAUTIs due to time and resource restrictions. Undetected CAUTIs cause further kidney and bladder infections and lead to increased length of hospitalization, excess healthcare costs, and increased mortality: The estimated cost per year for CAUTIs in the United States is $340 – $450 million. CAUTIcare proposes a way to provide automated screening to detect CAUTIs earlier in the infection progression. Our system uses a bimodal approach for the rapid detection of infections. First, we measure urine cloudiness (turbidity),, which is an early clinical indicator of infection. Turbid urine is then directed to a testing chamber, where a secondary, analyte-based test is performed to confirm infection. Turbidity detection triggers alarms to notify healthcare providers that a possible infection is present, drawing attention to the results of the dipstick test and requiring further medical care if needed. JawLign Joshua Fuller, Isabella Leite, Joseph Borison, Yeji Cho, Miranda Wang Up to 5% of the United States population has facial deformities such as temporomandibular joint disorders and cleft palates, which require orthognathic surgery to correct. Orthognathic surgery can have a relapse rate of 10% - 40%, in which the jaw moves back into the pre-surgical position. Relapse often occurs after patients have stopped coming in for frequent checkups, but can be remedied through orthodontics if identified early. Therefore, there is a need for patients to monitor their relative jaw position post-surgery without coming into the physician’s office. JawLign aims to create a platform to allow patients to track their jaw position at home, allowing for early detection of relapse. The JawLign platform uses dental impressions which can be analyzed in an app to track relative jaw position over time. Initial tests have demonstrated that wax molds can accurately measure jaw displacement, underlying their ability to be used in our device. 10
Biomedical Engineering SleepSense Keni Chen, Eileen Choi, Olimpia Gavaudan, Michelle Kim, Michael White Excessive Daytime Sleepiness (EDS) is characterized by falling asleep in an uncontrollable fashion, and is a major cause for accidents in high-risk situations. A reported 16.5% of fatal car crashes are attributed to people falling asleep. Uncontrollable sleepiness can often lead to unpredictable incidents, such as falling down while walking. However, current sleep pattern monitors focus primarily on recording and predict behaviors during nighttime. Safety devices related to EDS are only applicable to limited activities. SleepSense addresses the ambulatory need to track fatigue and uncontrolled sleeping throughout the day and alerts when sleepiness is detected. From our prototype testing, SleepSense was able to identify potential bouts of daytime sleepiness through changes in heart rate variability (HRV) and detection of stereotypical movements when falling asleep. As a lightweight, wearable, our device will allow for ambulatory monitoring and alerting of unregulated sleep, helping users combat falling asleep during critical activities CERV Hannah Ballard, Aala Nasir, Kiarra Lavache, Joyce Liu, Emme Pogue In the United States, 12% of children are born preterm, a leading contributor to infant mortality. During pregnancy, the cervix remodels to prepare for vaginal delivery by softening and shortening. Although cervical length is the clinical standard for diagnosing cervical insufficiency, research has shown premature cervical softening to be a more consistent indicator. We propose a biomechanical device to measure cervical stiffness, allowing patients the ability to monitor their risk of preterm birth more confidently and affordably. Our speculum-free device entails small-scale cervical compression to determine tissue stiffness. Proof of concept testing for circumferential compression of cervix phantoms has produced promising results for statistically distinguishing between different stiffnesses. We are confident that the successes of our proof of concept will translate directly into our final design and support risk detection of preterm labor. 11
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Senior Design Expo 2022

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