Investiture Program for Matthew B. Frieman, PhD

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MATTHEW B. FRIEMAN, PHD Matthew Frieman, PhD is a Professor in the Department of Microbiology and Immunology at the University of Maryland School of Medicine. His research focuses on highly pathogenic coronaviruses including the Severe Acute Respiratory Syndrome coronavirus (SARS-CoV), the Middle East Respiratory Syndrome coronavirus (MERS-CoV) and now SARS-CoV-2. Throughout his work he has balanced the study of the biology of these viruses with developing therapeutics against them. His work has been funded by NIH, BARDA, DARPA, The Bill and Melinda Gates Foundation and many industry partners, especially as SARS-CoV-2 emerged. Dr. Frieman grew up in Owings Mills, MD where he graduated Owings Mills High School in 1994 before attending Washington University in St. Louis where he majored in Biology. There he had the privilege to work all four years of college in the lab of Dr. Craig Pikaard working on ribosomal RNA silencing. It was there that he learned to love working in a lab, figuring out how to answer scientific questions and messing up countless experiments. It was there that he met Dr. Jill Fahrner, whom he would marry in 2003. He returned to Baltimore in 1998 and received his PhD at the Johns Hopkins School of Medicine where he worked in the lab of Dr. Brendan Cormack on yeast cell wall proteins. He was Dr. Cormack’s first graduate student and was able to see how to run a lab from the early stages of its development. Here he built his molecular biology skills and developed a love for yeast, which he uses in his laboratory today. After his PhD, Dr. Frieman followed his wife to North Carolina where she was finishing her MD/PhD, and he started a post-doctoral fellowship at the University of North Carolina at Chapel Hill in 2004 to study coronaviruses in the laboratory of Dr. Ralph Baric. SARS-CoV had emerged in 2003 and Dr. Baric was a longtime coronavirus researcher at the forefront of studying this new virus. His postdoctoral work focused on the identification of several SARS-CoV proteins that helped the virus block the immune response during infection, and how the host responded to SARS-CoV infection. In 2009, Dr. Frieman returned to Baltimore as an Assistant Professor in the Department of Microbiology and Immunology to start his laboratory continuing his work on coronaviruses. Since then, he has studied SARS-CoV, MERS-CoV (which emerged in 2012) and now SARS-CoV-2 with a focus on understanding the basic biology of these viruses, how they cause disease and developing therapeutics to fight them. Early in his research on coronaviruses, he focused on building animal models to study how the host responds to infection, and what pathways and proteins the viruses need to replicate and cause disease. These models laid the groundwork for research on coronavirus therapeutics, initially for SARS-CoV and MERS-CoV, but rapidly expanded to the study of SARS-CoV-2 in 2020. His lab has collaborated with many researchers and companies over the years including Regeneron, Novavax, AstraZeneca, Pfizer, and Eli Lilly on SARS-CoV-2 therapeutics.
WELCOME Mary Pooton Associate Dean for Development University of Maryland School of Medicine James B. Kaper, PhD Vice Dean for Academic Affairs James and Carolyn Frenkil Distinguished Dean’s Professor and Chair Department of Microbiology & Immunology Distinguished University Professor University of Maryland School of Medicine REMARKS Mark T. Gladwin, MD Vice President for Medical Affairs, UM Baltimore John Z. and Akiko K. Bowers Distinguished Professor and Dean, University of Maryland School of Medicine DONOR RECOGNITION Mark T. Gladwin, MD REMARKS Marco and Debbie Chacón Donors SPEAKERS Brendan Cormack, PhD Professor Department of Molecular Biology and Genetics Johns Hopkins University School of Medicine Ralph S. Baric, PhD William R. Kenan, Jr. Distinguished Professor Department of Epidemiology Professor Department of Microbiology and Immunology University of North Carolina at Chapel Hill Gillings School of Global Public Health Vineet D. Menachery, PhD Assistant Professor Department of Microbiology and Immunology University of Texas Medical Branch MEDAL PRESENTATION Mark T. Gladwin, MD REMARKS Matthew B. Frieman, PhD The Alicia and Yaya Viral Pathogen Research Professor of Microbiology & Immunology CLOSING REMARKS James B. Kaper, PhD
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Investiture Program for Matthew B. Frieman, PhD

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