PeloNews Spring 2024

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PELONews <strong>Spring</strong> <strong>2024</strong> Products Specialized Media and Supplements for MSCs To optimize EV isolation from MSCs, we advise using tailored products for each of the distinct stages, including isolation, maintenance, proliferation, and EV isolation. Made with BioRender 2023 For those seeking customization and control over their cell culture conditions, but wanting to use your own basal medium, we recommend using Human Platelet Lysate (hPL) serum supplementation from our trusted partner AventaCell. This can come in exosome-depleted versions which is perfect for implementing more control over your EVs being produced. Exosome depleted UltraGRO PURE GI Xeno-free, exosome-depleted, gamma-irradiated, and fibrinogen-depleted hPL available for research, clinical, and commercial use. At the moment, GMP qualities of gamma-irradiated hPL are available, while we wait for the GMP to come in the exosome-depleted version. Cat #: PB-HPCHEFRLI- - Quantities available: 50, 100, and 500 ml Alternatively, for those looking for complete off-the-shelf solutions of the highest quality standards, but still in research quality, PELOBiotech offers the following two media options in our Cellovations © brand! MSC growth medium (ready-touse) This medium consists of specially formulated MSC basal medium with added 10% fetal bovine serum and a mixture of growth factors to promote MSC proliferation. The medium is pre-mixed, ready to go, so it can be used immediately upon arrival! Cat #: PB-MH-675-0000-rtu 500ml Bottle MSC media kit, enhanced xeno-free Specialized defined media without any FBS. The media consists of optimized MSC basal medium and a cell culture supplement which contains a human platelet lysate derived growth factor mixture. When you are ready to use the medium, thaw and add the supplements to the basal medium, and you are ready to go. Cat #: PB-C-MH-675-0511-XF Yields 500ml of Medium 6 www.pelobiotech.com
Products Looking for complete off-the-shelf solutions but with clinical applications in mind ? We recommend chemically defined media in GMP quality from our partner Xcell. CellCor MSC CD AOF Animal origin-free chemically defined media for human-derived mesenchymal stem cells growth and proliferation composed of synthetic and recombinant proteins, rigorously tested for bioactivity, endotoxins, mycoplasma, and more. Cat #: PB-YSP018 500 ml bottle CellCor EXO CD Chemically defined media for stable MSC growth from different tissues, enabling high-quality exosome production. Versatile and compatible with various methods for consistent, reproducible results. Ideal for research and clinical applications. Promotes low aging and high genetic stability in MSCs from Adipose, Bone marrow, Cord blood, and Wharton jelly. Cat #: PB-YSP017 500ml bottle GMP-quality MSCs Now moving to the cells themselves, are you isolating and producing your own MSCs but are interested in potentially purchasing the cells in GMP quality? Did you know we carry bone-marrow derived MSCs in GMP quality from the renowned Swedish company Cellcolabs. These MSCs are: • Produced in a facility that is EU-GMP for iATMP approved. • Sourced from the bone marrow of young, healthy donors • Entirely xeno-free • Fully characterized according to the ISCT criteria Cellcolabs also produces EVs produced from the GMP quality human bone-marrow derived MSCs! The EVs are purified with a 0.22uM filter, characterized through the expression of CD9, CD63, and CD81 and lastly their size and number is verified using Zetaview. Want to try out these EVs for your application? Let’s have a conversation and make this happen! PELONews: Stay tuned for new xeno-free hydrogels! www.pelobiotech.com 7
Page 1 and 2: PELONEWS WITH A FOCUS ON MSC-EV RES
Page 3 and 4: Announcement PELONews: Our first an
Page 5: Overview Table 1. Comparison of Cel

PeloNews Spring 2024

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