nuhammad lsmall

More documents

Recommendations

Info

150.2 indicslcd lhe pt*n@ of Otl srcuF, Gp.ciiv€lv. Conpoud:r wd foud !o be idmrical to rhe rcponcd tBgDflorine, sli.r i$lded non Ckfunpelot Alabnino lBarbo*-Filho. J. M, €, di., l97l ll m Epqt d to be norcvtotoxic rgdn$ a wid€ tuee of ell tin6 [Mi!, Y. D., el. a1., 2006]. 3.lJ Tyra'nire atrd Othcr Afk ldd.froa Tinoqoft cft?a A nubd of ty@irc.ll loi& hlvc.le b€n ielaLd frod tieqo.. ctdPa, duin3 tn€ pEsl '.v*deatioo, 3.13.1 3.13.t.1 Thce includ. tw tt?dirc all loi& 22-t3 dd a nuclosidc 2l' Knoivn Con{ilr.tra Crnpoud 22 !d obtained ftom ihe edYl @lale exlr&t ot I ct sra (ExFrnndtll, setionJ.2,l.5.3, P.gc'138). lts Uv sretm show€d lh. aberption ndim .r 30s, 29 snd 225 d, indi@tive of a conjugated dna{c nDcdonality, The IR speltum showcd btoad.bstptiotr bon& ar 3620 ed 1640 cmr de io the Otl ed qFmetulted di
signars for rwo doubr€ doubters ar 6 6 67 (J!R ,2te 8 6Hz) u41 2? (.I* :r- &6 Hz)' d* to ,r,ro{@plbg of C-3'/C-5' eirh C-21C4,' t .l ofc-2rc{' virh C-3rc-5', E3p@tiYelv- Thc bndd-bald "c-tlt "petra (ExpniE)dLl, se.lionl-2 5 7, PagelSl) thoqed sigrals fd l7 6tds, iftludiig fou quorqD.ry (Cn, C4, C_ l md C'4 )' ten dcthirc (C' 2, CJ, c-5, C{, c-2', C-l', cJ', c'6, C-7' ad C'8), two mcthvl€& (C-7 ad C_8) ad d dide carbonyl c&r,on (rc 169 2) Cohpould 22 shov&d sinild sFctlrt darr s rh@ of p.p@iie, Epon d .!lid fm FMtua indi.a l{tltw-Rttutu, et dl . t942]'. 3.lj.l: ,V-I,@-t rnroyl.Yroilc (2!) Cmpound 23 s isbr.d tom lh. dhYl dciaL.xtz.t of t .ttuPa by uilg silica g€l @llM chrcDdogBphy (ErFrindt l, section-3.2.3.5.4. Pa8.-138) Ihe Uv sP€dtm showed .bealion msina 't 317' 293 dd 2S5 nn, irdi.aling th. Dllsc of d arenDtic fitudoDtlitv- ThG IR s!6LuD slbsed brcad absoptio! bdds .t 32oo 6tl 1655 cn-r,de lo OH ed d'Fwtdat'd mid€ clrbonyt 6etio$liti.3, BFctivcly fts HR.EI_MS showd Nf ai ttlz ll3ll09' corcspontlins !o lhe fo@d! CtrHreNOa (calcd 3l3l3l4)' wiih ten double bo'd .quivale . in lle noleule. TrErH- andriC-NMR sp€FM of@6Fu 23 (Expdimctrt l S.ction'3 2 1 5 4' Pas'' Il9) sho*e{t stu rat f.ai@ s clos b lhoe of @mpolnd 22,.xePi 1har onc me$oxv sroup rppeacd al dH 3.s9 (& 55.6) s a singlct, ad ! qoddDart ebon @MLd at 'c 147.8 insi€ad of one emlti. sienll ai ,H 6.67 (rc l3O 7) in conPowd 12 Thc posilion of lhc m.lhoxy 8rcup E ddmincd o! lb. bsis of th. @@latiotr of th' relhoxv potons esonaiing at,3.89 withC-l (147 8). r-tiY'
Page 1 and 2:
Irohtion rnd StructE!'e Elrcidrdotr
Page 3 and 4:
Th.si! C€dficate Ttir b to oltry
Page 5 and 6:
ta-----i.at--*Lt*-tt-A rt-rcr-#a.ll
Page 7 and 8:
3.0.I.ibtior ud ChDclelation of Sso
Page 9 and 10:
32313 t.231.4 3,23j5 3,23.4,6 3,23!
Page 11 and 12:
FiRt &d fom6l I oFq bJ' sim.6t Snd
Page 13 and 14:
I.tFd&dor of Ph. D. R.6EL Sctlohr I
Page 15 and 16:
Thc ct]@tedarior ad stu.nr! .lucidd
Page 17 and 18:
2) Klom Cl.dd.n6lt?. Funrodit r!.n.
Page 19 and 20:
S.ction-B A higbly dliv. ed sel4til
Page 21 and 22:
GENER.AL INTRODUCTION
Page 23 and 24:
ag6ts [&on' 1992; VeL, D. J.H-,4 aL
Page 25 and 26:
fic. 1.1 MediciBlly imPodrnt Mlural
Page 27 and 28:
cfcds. chin* tiditio!.I mdiciB mill
Page 29 and 30:
iui@ for wic.s plsvid.d by rft@dirc
Page 31 and 32:
@nrodds, including el.ven n w aad a
Page 33 and 34:
2.0 INTRODUCTION z.l 2.1.1 Itrloduc
Page 35 and 36:
Ti6pda baeigi F@ has b@ u$d 6 4 4ti
Page 37 and 38:
.l. Ird@si!: bFtlvaq ed.{tli, putiq
Page 39 and 40:
2,2.0 secondaryMet bolites of Tinos
Page 41 and 42:
:i I a rl t 3 a' t I ax '^z :t F 9
Page 43 and 44:
2 i c I F 6 c B { t E 6' "o I b E s
Page 45 and 46:
lt 1|'
Page 47 and 48:
-48 r1l .b 'i-{tr 62 63 64 ADrL.prr
Page 49 and 50:
Flhsy ir th. chloDpLst fo@ IPP for
Page 51 and 52:
T I (3P4 c"i I l'+P4 I l-- ]_".*"'
Page 53 and 54:
A c'19 mehyl sltift to C-5 in ?E (r
Page 55 and 56:
CHAPTER.3 R.ESUIL]IS AND DISCUSSION
Page 57 and 58:
Nays were also pdfom.d on najd coin
Page 59 and 60:
CoDpound I ha rhe dol@ule fomuro Cl
Page 61 and 62:
s d.dE d rt r c.l3 (& 82.0) 5nd C-l
Page 63 and 64:
tr'\ ) c6Hi -8 )a coHto" r|.. 3.4!
Page 65 and 66:
!.1.1.12 2-lydnryhonP.i@l& c (2) IU
Page 67 and 68: 1.65 (H-l lb) sho*.d CosY creePct}l
Page 69 and 70: f + I t ri \\ Sc!@e3} MN tugncltiti
Page 71 and 72: 3.1.1.1, IUPAC: (2r,5r,6X,8S,9S,1 O
Page 73 and 74: al rc 140.7 ws due ro c-3 ol.finic
Page 75 and 76: T.brF3-3: '3C- &d 'H-NMR'ch@i.d sbi
Page 77 and 78: $-nMrumr.d dbonyl sysrstr. Thc 'H-N
Page 79 and 80: 6 (& 4.39) snd C-8 (dH 33E) nldhiE
Page 81 and 82: T.bF!,a: I'c'- dd I H-NMR' ch.oical
Page 83 and 84: IL, ru), 3.80 (d4 .r6,a 6!= I 1.8 H
Page 85 and 86: The st rcochedsrry in conpoud s B d
Page 87 and 88: a.r,l.l.6 Ti!@rnDoridc D (6) IUPAC:
Page 89 and 90: Trblr3J: 't^' ald 'H"NMR' chdic.l l
Page 91 and 92: (orqlrp, Hl lb) *a ai8tr.d to rh. C
Page 93 and 94: Thc HMBC s!6um of cmpoud 7 supPoncd
Page 95 and 96: J.l,l.l.8 Bonp.l6id. r (E) IUPAC: M
Page 97 and 98: .tC{e.I a{naterl wbjle M620. H-5. H
Page 99 and 100: t 1.1.1,9 IUFACT Mlrhyl (21,6s.54x,
Page 101 and 102: T.btF!J| rrc'- &d 'H-1,\4R'chmiol 3
Page 103 and 104: .dboro. ft. do*nfi€ld signals a1
Page 105 and 106: and 2D spetFl .lrL with th€ Epork
Page 107 and 108: speiru, th. preton sigtrd .t ,x l2l
Page 109 and 110: -*v*L Puilicat on of ii&tion Bwl (5
Page 111 and 112: d6tu .n Th. h! Eoidi.. h lh. rt$.dd
Page 113 and 114: 3.12.2 4.12,2.1 Krown Col3liluera!
Page 115 and 116: J.IJ,2J rv-rodtbomucif.ri!.09) Comp
Page 117: 3.1.2.2,5 M.s!ododrc(21) compound 2
Page 121 and 122: 3.1.3.1.4 Cylidi!.(25) Conpoutrd 25
Page 123 and 124: J.l.a.l3 Cy.h.!€L!ol(2t) Conlound
Page 125 and 126: CHAP:TER. 3 E)GERIMENTAI
Page 127 and 128: 3.2.1.2J Collm chnbltogbpny vs Frfo
Page 129 and 130: Lol.rio! ol Pon constit!.llt fmd t-
Page 131 and 132: 3 .? a a 3 t : t t ! .4 ? I F € E
Page 133 and 134: f, -" 3i ii IF ls tt t; ! 3 I iI !E
Page 135 and 136: S.[cne!.|rr Isolation of compounds
Page 137 and 138: t-Hydotybonpct6irlG c o) IUPAC, (2x
Page 139 and 140: ldlD'r -35-d (c 0.056, cHroH) IR (K
Page 141 and 142: tdlD I'r +135.1./ (. 0.0?a, Cs3otD
Page 143 and 144: FA&MS Cvc) ,,/r: 519 [M - tt]- EFMS
Page 145 and 146: 313.,1.0 sub-6*tion Fry2 (900 ms) f
Page 147 and 148: '&Nre (cDclr, 300 MH2) ,, 2.21 (lH,
Page 149 and 150: sa Hib), 3.80 0 H, dd J6! trr= I l-
Page 151 and 152: P€rcenb8. yl.ld: l4,Ox l0' Strr.:
Page 153 and 154: 'H-NMR (CDrOD, l0O MH') t: 1.73 (lH
Page 155 and 156: atrord @mDoDd 16 (1.4 6& 2.1 x l0r%
Page 157 and 158: 323.4$.2 (zlN-FomyL0on.b. (U-z) 'H-
Page 159 and 160: Elryana W @eorD r-. m (log r): 310
Page 161 and 162: Itc.Nlm (cDct3, l m mL,) d: t 46.0
Page 163 and 164: 106). InErpidation of spetd .rd phy
Page 165 and 166: AIMS Cvc) a'zi 242 tM- Hl EI-MS r'l
Page 167 and 168: prcduced conpobd 2E (13.6 h8,8.5 cn
Page 169 and 170:
CFIAPTER. 4 BIOLOGICAI ASSAYS
Page 171 and 172:
2002; Yotodq 'r., .t al, 2OOlt Csvi
Page 173 and 174:
I oourobodubrorr rctivir' dilb rhol
Page 175 and 176:
q@ us€d s d.ndards for II3 rd !C'
Page 177 and 178:
. Chitri.lw, G.; Jai., Al sip6hin l
Page 179 and 180:
. M4.iakd, P. N; Joly, C I iN@!@4s
Page 181 and 182:
. Sk4 Y. C.; ChoS; Y. B.: Aln d, A
Page 183 and 184:
Chrpt r 5 Applic.tion of NucLophili
Page 185 and 186:
MuuSe in 2o0l md steSlich in 1969 E
Page 187 and 188:
5.13 Cbirrl Nucleophilic Acyl Trrff
Page 189 and 190:
'nr€ chihl vc$ion of DMAP catalys
Page 191 and 192:
Tl@tuE, ii E NuD.d thal a gcrad 6Pi
Page 193 and 194:
11! R- h.ix, (-R-qqjrcct$r !1&R'p q
Page 195 and 196:
Recr)6t llialio! of r19. (4E% ec) n
Page 197 and 198:
|he cidut elvc sisral (CDCL), whil.
Page 199 and 200:
i3.r.2,4 At wEi. Srnth.s6 Sy I6i. o
Page 201 and 202:
coniimB stirins bcf@ t!'@ling tl -7
Page 203 and 204:
To a $lurion of KHMDS in THF (1.2
Page 205 and 206:
yeuow sorid. |E-NMR (400 MIIZ, CDCb
Page 207 and 208:
visoE liquid. wde obhined. fte cry3
Page 209 and 210:
A elution of €ialyst 93 (1.5 ns,
Page 211 and 212:
5.6 GLOSSARY . 'I|-NMR SlstrD: A on
Page 213 and 214:
Elcrntr lDp.ct Ma Spetnu (EI-MS): A
Page 215 and 216:
Org.non.t Uic: Orgdic ohpoo!& onlai
Page 217 and 218:
EI Er-i,{s- Ert|r FAB Fis. H HMBC c
Page 219 and 220:
N ROESY RP RT SN -siE rot fng t@ Ot
show all

nuhammad lsmall

Create successful ePaper yourself

Delete template?

Save as template?