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SUMMARY<br />
-the disendion is divi&d into iwo s€tionst stioro A dd B. s.clion a de$ribs lhe<br />
ielation dd st!.tN clki.ladon of tw6ly nine s@trddy mc|alrolitd Aon liMlo.a<br />
..tupa. h ale dcsibd thc ctioloncig .!d im@onodulatory 4iivni6 of th. mjot<br />
netaboliies of lirorprra 'ir@. Salion B desibes th€ applicalion of nucl@philic<br />
daiysis (o liie 6'1fueric gd€rarion of qu|mry sl€Eogdic.{16 and fomal total<br />
synrh.sis of Cbhy$srismine.<br />
This pan coDpnss phtl@hdical invcsligdioN oD enal p.ns of Tinospqq ctitpa \L.)<br />
Mi€6. It inchrl€s ielation dd stnature .leidatiotr of dn€ nd r-9 Gi8. l-2) dd sir<br />
rtus l().l5 (Fi& 2-3) claldac-type iluodirdpenoi&, .long with a tr* apoDhi@<br />
alkdoi.ls 16 (Fig. 4). This sludy yi€lded fiv. trou aporphine a[.loids 17-21 (Fi8. 5) dd<br />
two lytuin€ dkaloiG t2 ed 23 Gie. t), Thc olnd krom co8tit@6, islarcd ftob<br />
Ti@sporc .ritpa, iftlude Delhyl3,4njhydrcxrbeierc @a), c}{rdDe (15), syrinsin<br />
(26),5,7-dihy(Lbxy-2-(4-hydDxyphcnyl)-41l-l-b€mp'm-4-onc (24. crcteucale.ol<br />
(28)md3-Cl-D-glucopFdosyl-r{itostemt(29)(Iis.5).<br />
TLe isolalion of pl&l sn.bry n€ratolit s &hdvd wirh rhc help of nomat dd e!@<br />
phe chomiognphic tcchniqucs by Ning silica gel, poly-mide, Diaion HP .20 resia<br />
ODS (RP-18), S€phadex LH-20,.1c. Prcpdrive H?LC (L-Eo, M-80 ad H-80, tH ed<br />
2H, CS.l20, elc) @ u.d for 6n l puifi€rion of @npoudr from builetic exF.cl of
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