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D. J. H., er dl., 19921. ScicntiiB in Chh4 GcmMy, India md Jopa4 mong oilt€N, ae<br />
ale s.ding wild pldt sFi6 fd fte dsg5. It Edt phtme.'tical $16 ir glob.l<br />
mr.|.t ple is ple*nt d in Fig. 2-3<br />
t.1.4 Role of Medicin|l Cheniltry ir D.ug Developnenl<br />
Tddirionally MnDl podwts have play.d e inpofldt rele i. dru8 disldy, bll in dlc<br />
l&l tqo dccad6 of 206 6tury, @jor ph@@uricd @npdi4 has .ftnd t.miml€d<br />
oi $alcd doM then d$g di$ov{y pbgmme bed t n natu6l e@6, d.spilc lhe<br />
rer $d top 35 rcrldwid. s.llqs dngs in 2000-2002 l* @mplcGly b4€d on narud<br />
pod@B. Ituing rh. yd 200G2003, 15 Ee Mtur.l predFH.dv.d dfl8s *E<br />
intodwd in the ms*ct, elil€ 15 naturl produ.iddived @mpouds w in ph.l. lll<br />
clinical t ials [Bull.r, M. S., 2004]. Reently, th€ ph@urictt .onpdi.s 4€ showitrs<br />
cft*cd ior4$ in Dtural proder !t*4h ds ro lh. f.nm of dLhative {,$s disorcry<br />
m.dod. to ptuvide lcad @mpouds, s wtl d lo coF wilh th. chdldgB of.herging<br />
dis.5s s@h s imue rcl6red disorders, vir.l di*es dd nct bolic di$rd6 [Burl.r,<br />
M. S,, 2004; latwedhd, 8., et 4r, 20041. To codpele wirh othd dng di$ovdr m€lho&,<br />
Mlur.l lrodud $icfu hs adopLd bigh 3p..d mii8, i$larion, od sfucrN<br />
el@idalion techniquB. ftk B o y po$iblc by iltodeins h}?hcrul.d teclniqes srch<br />
s LC-MS/MS, LC-DAD-MS/SPE-NM& LGMS-Nl\tr, CC-MS along with hiSh-<br />
thrcuSlpui bioey sc@ai!! t€chniqB.<br />
1.1.5 Objectiv6 of Curretrt Study<br />
Thc ain of the c@nt sludy *a to s.eh for ncw bioeriv. saonda.y mer.bolites ftom s<br />
ndicirGl pler Tinspotu oiqp of MalaFi4 o.igi!. 'Itjs plad ha @y folldoric lg<br />
in $c Mdlysi& tsLn of n dicie. rrir lirdy ha Gultcd in th. isolalion of rhiny
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