General embryological information service - HPS Repository

other physical agents, 6. Infectious diseases, 7. Nutritional deficiencies
and excesses, 8. En±iryotoxicity of drugs in man, 9. Environmental chemicals,
10. Maternal metabolic and endocrine imbalances, 11. Atmospheric
gases - variations in concentration and some common pollutants, 12. Extremes
of temperature, 13. Interactions and multiple causes.
Contents vol.2: ill. initiating mechanisms and early pathogenesis: 1. Gene
expression and its regulation, 2. Developmental genetics, 3. Numerical and
structural chromosome abnormalities, 4. Cell death and reduced proliferative
rate, 5. Altered biosynthesis, 5. Embryonic intermediary metabolism
under normal and pathological conditions, 7. Altered electrolyte and fluid
balance, 8. Abnormal cellular and tissue interactions, 9. Cell morphogenetic
movements, 10. Alterations in the metabolism of glycosaminoglycans and
collagen, 11. Time-position relationships, with particular reference to
cleft lip and cleft palate, 12. Teratogenesis and oncogenesis; IV. Examples
of abnormal organogenesis: 13. Abnormal organogenesis in the eye, 14.
Abnormal organogenesis in the cardiovascular system, 15. Abnormal organogenesis
in the urinary tract, 16. Abnormal organogenesis in the reproductive
system, 17. Abnormal organogenesis of facial structures, 18. Abnormal
organogenesis in the limbs.
Contents vol.3: v. Maternal and placental effects: 1. Maternal and cytoplasmic
effects in experimental teratology, 2. Factors that affect drug
concentrations in maternal plasma, 3. Effects of placental pathology on
the embryo and fetus; VI. Comparative studies in maxi and other mammals:
4. Summary of comparative embryology and teratology, 5. Comparative placental
transfer; VII. Epidemiology: 6. Detection and evaluation of pregnancy
wastage, 7. Value and methods of animal studies- in epidemiology, 8.
Birth defects registries and surveillance, 9. Correlations of malformation
frequency with environmental and genetic attributes in man
Contents vol.4: VIII. Research procedures and data analysis: 1. Techniques
for cytogenetic analysis, 2. Mutation testing systems, 3. Cell,
tissue, and organ culture as teratologic tools, 4. Whole embryo explants
and transplants, 5. Survey of in vitvc systems: their potential use in
teratogenicity screening, 6. The structure and uses of genetically homogeneous
lines of animals, 7. Multigeneration reproduction studies, 8- The
design of subprimate animal studies, 9. Feasibility and design of subhuman
primate studies, 10. Uterine vascular interruption and combined radiation
and surgical procedures, 11. Analytical techniques for the study of teratogenic
mechanisms, 12. Immunological aspects of development, 13 Behavioral
teratology, 14. Methods and concepts of biometrics applied to teratology
One or more volumes of this monumental multi-author treatise have already
been reviewed and, on the whole, acclaimed in the scientific press (see e.g.
Nature 27d) . We list the tables of contents as a service to our readers.
The work is a veritable mine of information and will be invaluable to all
teratologists and particularly to beginning investigators. Reviews such as
the chapters 2, 4, and 7-10 in vol.2 are also of interest to mammalian embryologists
generally (the authors are Gluecksohn-Waelsch, W.J.Scott, Jr.,
Grabowski, Saxen, K.M.Yamada, and Kochhar and Larsson) . The same holds for
chs.4 and 5 in vol.3 (by Nishimura and Shiota, and Beck and Lloyd).
The volumes are well produced and illustrated.
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