David Matchar - CV - Health Services and Systems Research - Duke ...

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CURRICULUM VITAE
DAVID BRUCE MATCHAR, MD, FACP, FAHA
Date Prepared: 31/08/2011
Inaugural Director and Professor, Program in Health Services and Systems
Research,
Duke-NUS Graduate Medical School, Singapore
Professor, Department of Internal Medicine (General Internal Medicine)
Duke University Medical Center, Durham, NC
Director, Duke Center of Clinical Health Policy Research
North Carolina License # 27243; Maryland License #D0025434
Diploma in Internal Medicine, 1984
Available Upon Request
Place of birth: Baltimore, MD
Citizen of: USA
Education:
1972 Pikesville Senior High School, Baltimore, MD
1976, AB Department of Statistics, Princeton University, Princeton, NJ
1976 School of Public Health, Harvard University, Boston, MA
1977 Epidemiology Intelligence Service, Training Course, Center for Disease Control,
Atlanta, GA
1980, MD School of Medicine, University of Maryland, Baltimore, MD
1983 Fellow in General Internal Medicine Department of Medicine, Duke University
Medical Center, Durham, NC
1984 Visiting Fellow, Division of Clinical Decision Making, New England Medical Center,
Boston, MA

Professional Experience:
1975 Statistician, Center for Environmental Studies, Princeton, NJ
1977 Assistant Statistician, Centers for Disease Control, Atlanta, GA
1980 Intern, University of Maryland Hospital, Department of Medicine, Baltimore, MD
1981 Junior/Senior Assistant Resident, University of Maryland Hospital, Department of
Medicine, Baltimore, MD
1983 Instructor, Physical Diagnosis, Duke University Medical Center, Durham, NC
1985 Research Associate, Health Services Research Field Program, VA Medical
Center, Durham, NC
1985 – 1987 Associate in Medicine, Division of General Internal Medicine, Department of
Medicine, Duke University Medical Center, Durham, NC
1985 – 2008 Staff Physician, Ambulatory Care Service, VA Medical Center, Durham, NC
1987 – 1993 Assistant Professor, Division of General Internal Medicine, Department of
Medicine, Duke University Medical Center, Durham, NC
1985 Medical Director, Hospital Based Home Care Program, VA Medical Center,
Durham, NC
1988 - Director, Center for Health Policy Research and Education (renamed: Center for
Clinical Health Policy Research, 1997), Duke University Medical Center, Durham,
NC
1989 – 1994 Adjunct Assistant Professor, Department of Health Policy and Administration
School of Public Health, University of North Carolina, Chapel Hill, NC
1989 – 1994 Assistant Research Professor, Institute of Statistics and Decision Sciences, Duke
University Medical Center, Durham, NC
1993 – 1999 Associate Professor with Tenure, Department of Medicine, Duke University
Medical Center, Durham, NC
1994 – 1999 Adjunct Associate Professor, Department of Health Policy and Administration
School of Public Health, University of North Carolina, Chapel Hill, NC
1996 -
Senior Fellow, Center for the Study of Aging and Human Development, Duke
University Medical Center, Durham, NC
1997 – 2008 Director, Evidence-based Practice Center, Duke University Medical Center,
Durham, NC

1999 - Professor with Tenure, Department of Medicine, Duke University Medical Center,
Durham, NC
2008 - Professor and Inaugural Director, Program in Health Services and Systems
Research, Duke-NUS Graduate Medical School, Singapore
2009 - Professor, Department of Pathology, Duke University Medical Center, Durham, NC
Publications:
1. Matchar DB, Coffey CE, Feussner JR. Late reporting of sudden vision loss. North
Carolina Medical Journal. 45(4):211-212, 1984.
2. Harrell FE, Lee KL, Matchar DB, Reichert TA. Regression-models for prognostic
prediction - advantages, problems, and suggested solutions. Cancer Treatment
Reports. 69(10):1071-1077, 1985.
3. Matchar DB, Feussner JR. Laboratory tests in the diagnosis of vitamin-B12
(cobalamin) deficiency. North Carolina Medical Journal. 47(3):118-120, 1986.
4. Matchar DB, Feussner JR, Watson DJ, Wilkinson J, Millington DS, Gale D.
Significance of low serum vitamin-B12 levels in the elderly. Journal of the American
Geriatrics Society. 34(9): 680-681,1986.
5. Matchar DB, Pauker SG. Transient ischemic attacks in a man with coronary-artery
disease - two strategies neck and neck. Medical Decision Making. 6(4):239-249,
1986.
6. Feussner JR, Simel DL, Matchar DB. Quantitative approaches to clinical diagnosis
of cancer in elderly patients. Clinics in Geriatric Medicine. 3:447- 461, 1987.
7. Matchar DB, Feussner JR, Millington DS, Wilkinson RH, Watson DJ, Gale D.
Isotope-dilution assay for urinary methylmalonic acid in the diagnosis of vitamin-B12
deficiency - a prospective clinical-evaluation. Annals of Internal Medicine.
106(5):707-710, 1987.
8. Matchar DB, Pauker SG. Endarterectomy in carotid-artery disease - a decisionanalysis.
JAMA-Journal of the American Medical Association. 258(6):793-798, 1987.
9. Simel DL, Feussner JR, Delong ER, Matchar DB. Intermediate, indeterminate, and
uninterpretable diagnostic test results. Medical Decision Making. 7(2): 107-
114,1987.
10. Feussner JR, Matchar DB. When and how to study the carotid arteries. Annals of
Internal Medicine. 109(10):805-818, 1988.
11. Feussner JR, Matchar DB. Diagnostic evaluation of the carotid arteries. Annals of
Internal Medicine. 109(10):835-837, 1988.
12. Simel DL, Matchar DB, Piscitelli JT. Routine intravenous pyelograms before
hysterectomy in cases of benign disease - possibly effective, definitely expensive.
American Journal of Obstetrics and Gynecology. 159(5):1049-1053, 1988.
13. Simel DL, Piscitelli J, Matchar DB. Intravenous pyelography before hysterectomy.
Annals of Internal Medicine. 111(6): 541-541, 1989.
14. Goldstein LB, Matchar DB, Morganlander J, Davis JN. The influence of drugs on the
recovery of sensorimotor function after stroke. Journal of Neurological
Rehabilitation. 4:137-144, 1990.
15. Gusberg SB, Lowman J, Fleming ID, Beahrs OH, Henley CE, Mixson WT, McGivney
WT, Matchar DB, Mortenson LE, Hogan CM. Health professional concerns in the
practice setting. Cancer. 65(10):2413-2414, 1990.

16. Matchar DB. Technology-assessment and guideline development - concerns and
opportunities for academic general internists. American Journal of the Medical
Sciences. 300(3):171-172, 1990.
17. Matchar DB. Decision-making in the face of uncertainty - the case of carotid
endarterectomy. Mayo Clinic Proceedings. 65(5):756-760, 1990.
18. Matchar DB, Geweke JF, Simel DL, Feussner JR. Uniform priors arent a thing of the
past - response. Medical Decision Making. 10(2):114-115, 1990.
19. Matchar DB, Simel DL, Geweke JF, Feussner JR. A Bayesian method for evaluating
medical test operating characteristics when some patients conditions fail to be
diagnosed by the reference-standard. Medical Decision Making. 10(2): 102-
112,1990.
20. Murphy DJ, Matchar DB. Life-sustaining therapy - a model for appropriate use.
JAMA-Journal of the American Medical Association. 264(16):2103-2108, 1990.
21. Horner RD, Matchar DB, Divine GW, Feussner JR. Racial variations in ischemic
stroke related physical and functional impairments. Stroke. 22(12):1497-1501, 1991.
22. Linzer M, Prystowsky EN, Divine GW, Matchar DB, Samsa G, Harrell F, Pressley JC,
Pryor DB. Predicting the outcomes of electrophysiologic studies of patients with
unexplained syncope - preliminary validation of a derived model. Journal of General
Internal Medicine. 6(2):113-120, 1991.
23. Matchar DB. Two-Sided Matching: A study in game-theoretic modeling and analysis.
Medical Decision Making. 11:229, 1991.
24. Shlian D, Matchar DB, Seymann GB. Cost-effectiveness evaluation of measles
immunization strategies on a college campus. Family Practice Research Journal.
11:193-207,1991.
25. Simel DL, Matchar DB, Feussner JR. Diagnostic-tests are not always black or white -
or, all that glitters is not (a) gold (standard). Journal of Clinical Epidemiology. 44(9):
967-970,1991.
26. Simel DL, Samsa GP, Matchar DB. Likelihood ratios with confidence - sample-size
estimation for diagnostic test studies. Journal of Clinical Epidemiology. 44(8):763-
770, 1991.
27. Duncan PW, Goldstein LB, Matchar D, Divine GW, Feussner J. Measurement of
motor recovery after stroke - outcome assessment and sample-size requirements.
Stroke. 23(8):1084-1089, 1992.
28. Matchar DB, Divine GW, Heyman A, Feussner JR. The influence of hyperglycemia
on outcome of cerebral infarction. Annals of Internal Medicine. 117(6):449-456, 1992.
29. Glass TA, Matchar DB, Belyea M, Feussner JR. Impact of social support on outcome
in first stroke. Stroke. 24(1):64-70, 1993.
30. Matchar DB, Duncan PW, Samsa GP, Whisnant JP, Defriese GH, Ballard DJ, Paul
JE, Witter DM, Mitchell JP. The stroke prevention patient outcomes research team -
goals and methods. Stroke. 24(12):2135-2142, 1993.
31. McCrory DC, Goldstein LB, Samsa GP, Oddone EZ, Landsman PB, Moore WS,
Matchar DB. Predicting complications of carotid endarterectomy. Stroke. 24(9):1285-
1291, 1993.
32. Oddone EZ, Cowper P, Hamilton JD, Matchar DB, Hartigan P, Samsa G, Simberkoff
M, Feussner JR. Cost-effectiveness analysis of early zidovudine treatment of HIVinfected
patients. British Medical Journal. 307(6915):1322-1325, 1993.
33. Oddone EZ, Horner RD, Monger ME, Matchar DB. Racial variations in the rates of
carotid angiography and endarterectomy in patients with stroke and transient
ischemic attack. Archives of Internal Medicine. 153(24):2781-2786, 1993.

34. Papadakis MA, Lee KK, Browner WS, Kent DL, Matchar DB, Kagawa MK,
Hallenbeck J, Lee D, Onishi R, Charles G. Prognosis of mechanically ventilated
patients. Western Journal of Medicine. 159(6):659-664, 1993.
35. Schapira MM, Matchar DB, Young MJ. The effectiveness of ovarian cancer
screening - a decision-analysis model. Annals of Internal Medicine. 118(11):838-
843, 1993.
36. Simel DL, Samsa GP, Matchar DB. Likelihood ratios for continuous test results -
making the clinician job easier or harder. Journal of Clinical Epidemiology. 46(1):85-
93, 1993.
37. Duncan PW, Goldstein LB, Horner RD, Landsman PB, Samsa GP, Matchar DB.
Similar motor recovery of upper and lower extremities after stroke. Stroke.
25(6):1181-1188, 1994.
38. Goldstein LB, Matchar DB. The stroke PORT: secondary and tertiary prevention of
ischemic stroke. Health Reports. 6:154-159, 1994.
39. Goldstein LB, Matchar DB. Clinical-assessment of stroke. JAMA-Journal of the
American Medical Association. 271(14):1114-1120, 1994.
40. Goldstein LB, McCrory DC, Landsman PB, Samsa GP, Ancukiewicz M, Oddone EZ,
Matchar DB. Multicenter review of preoperative risk factors for carotid
endarterectomy in patients with ipsilateral symptoms. Stroke. 25(6):1116-1121,
1994.
41. Goldstein LB, McCrory DC, Samsa GP, Oddone EZ, Landsman P, Moore WS,
Matchar DB. Multicenter review of preoperative risk factors for carotid
endarterectomy (CEA) in patients with ipsilateral symptoms. Stroke. 25(1):273-273,
1994.
42. Matchar DB, Duncan PW. Cost of stroke. Stroke: Clinical Updates. 5:9-12,1994.
43. Matchar D, McCrory D, Pritchett ELC. Management of atrial fibrillation. Annals of
Internal Medicine. 121(6):466-467, 1994.
44. Matchar DB, McCrory DC, Barnett HJM, Feussner JR. Medical treatment for stroke
prevention. Annals of Internal Medicine. 121(1):41-53, 1994.
45. Matchar DB, McCrory DC, Barnett HJM, Feussner JR, Mazzaferri EL, Huth EJ,
Kerby GR, Klocke FJ, Kussman MJ, Marton KI, Mulley AG, Mushlin AI, Palda VA,
Thibault GE, Thomson GE, Harrison CE, Cassel CK, Gullen DJ, Webster JR,
Addington W, Berenson R, Gary NE, Greenfield S, Haywood J, Lopez AM, Traynor
MV, White LJ. Guidelines for medical treatment for stroke prevention. Annals of
Internal Medicine. 121(1):54-55, 1994.
46. Matchar DB, McCrory DC, Millington DS, Feussner JR. Performance of the serum
cobalamin assay for diagnosis of cobalamin deficiency. American Journal of the
Medical Sciences. 308(5):276-283, 1994.
47. Oddone EZ, Samsa G, Matchar DB. Global judgments versus decision-modelfacilitated
judgments - are experts internally consistent. Medical Decision Making.
14(1):19-26, 1994.
48. Bennett CL, Oddone E, Matchar DB. Cost-effectiveness models of clinical trials of
new pharmaceuticals for AIDS-related pneumocystis carinii pneumonia: are they
helpful to policy makers? Clinical Performance & Quality Health Care. 3:156-164,
1995.
49. Blakeley DD, Oddone EZ, Hasselblad V, Simel DL, Matchar DB. Noninvasive carotid
artery testing - a metaanalytic review. Annals of Internal Medicine. 122(5):360-367,
1995.
50. Goldstein LB, Bonito AJ, Matchar DB, Duncan PW, Defriese GH, Oddone EZ, Paul
JE, Akin DR, Samsa GP. US national survey of physician practices for the secondary

and tertiary prevention of ischemic stroke - design, service availability, and common
practices. Stroke. 26(9):1607-1615, 1995.
51. Goldstein LB, Hasselblad V, Matchar DB, McCrory DC. Comparison and
metaanalysis of randomized trials of endarterectomy for symptomatic carotid artery
stenosis. Neurology. 45(11):1965-1970, 1995.
52. Horner RD, Matchar DB, Divine GW, Feussner JR. Relationship between physician
specialty and the selection and outcome of ischemic stroke patients. Health Services
Research. 30(2):275-287, 1995.
53. Horner RD, Oddone EZ, Matchar DB. Theories explaining racial differences in the
utilization of diagnostic and therapeutic procedures for cerebrovascular-disease.
Milbank Quarterly. 73(3):443-462, 1995.
54. Matchar DB, McCrory DC, Barnett HJ, Feussner JR. Medical treatment for stroke
prevention. Annals of Internal Medicine. 122:235-236, 1995.
55. McCrory DC, Matchar DB, Samsa G, Sanders LL, Pritchett ELC. Physician attitudes
about anticoagulation for nonvalvular atrial fibrillation in the elderly. Archives of
Internal Medicine. 155(3):277-281, 1995.
56. Moore WS, Barnett HJM, Beebe HG, Bernstein EF, Brener BJ, Brott T, Caplan LR,
Day A, Goldstone J, Hobson RW, Kempczinski RF, Matchar DB, Mayberg MR,
Nicolaides AN, Norris JW, Ricotta JJ, Robertson JT, Rutherford RB, Thomas D,
Toole JF, Trout HH, Wiebers DO. Guidelines for carotid endarterectomy - a
multidisciplinary consensus statement from the ad hoc committee, American Heart
Association. Circulation. 91(2):566-579, 1995.
57. Tsevat J, Cook EF, Green ML, Matchar DB, Dawson NV, Broste SK, Wu AW, Phillips
RS, Oye RK, Goldman L. Health values of the seriously ill. Annals of Internal
Medicine. 122(7):514-520, 1995.
58. Westman EC, Matchar DB, Samsa GP, Mulrow CD, Waugh RA, Feussner JR.
Accuracy and reliability of apical S3 gallop detection. Journal of General Internal
Medicine. 10(8):455-457, 1995.
59. Bennett CL, Matchar D, McCrory D, McLeod DG, Crawford ED, Hillner BE. Costeffective
models for flutamide for prostate carcinoma patients - are they helpful to
policy makers? Cancer. 77(9):1854-1861, 1996.
60. Boiney L, Winkler R, Sarin R, Matchar DB. Combining patient utility with health
status assessment to improve medical decision-making. Journal of Decision
Analysis. 5:248-258, 1996.
61. Edelman D, Matchar DB, Oddone EZ. Clinical and radiographic findings that lead to
intervention in diabetic patients with foot ulcers - a nationwide survey of primary care
physicians. Diabetes Care. 19(7):755-757, 1996.
62. Goldstein LB, Bonito AJ, Matchar DB, Duncan PW, Samsa GP. US national survey
of physician practices for the secondary and tertiary prevention of ischemic stroke -
medical therapy in patients with carotid artery stenosis. Stroke. 27(9):1473-1478,
1996.
63. Goldstein LB, Bonito AJ, Matchar DB, Duncan PW, Samsa GP. US national survey
of physician practices for the secondary and tertiary prevention of ischemic stroke -
carotid endarterectomy. Stroke. 27(5):801-806, 1996.
64. Goldstein LB, Bonito AJ, Matchar DB, Samsa GP. National survey of stroke
prevention practices: Surgical management. Stroke. 27(1): 32-32,1996.
65. Goldstein LB, Bonito AJ, Samsa GP, Matchar DB. US national survey of physician
practices for stroke prevention: Medical therapy in patients with carotid artery
stenosis. Neurology. 46(2):26006-26006, 1996.

66. Govert JA, Kopita JM, Matchar D, Kussin PS, Samuelson WM. Cost-effectiveness of
collecting routine cytologic specimens during fiberoptic bronchoscopy for
endoscopically visible lung tumor. Chest. 109(2):451-456, 1996.
67. Leape LL, Hilborne LH, Schwartz JS, Bates DW, Rubin HR, Slavin P, Park RE,
Witter DM, Panzer RJ, Brook RH, Kelly J, Bluth E, KrouselWood T, Komaroff A,
Matchar D, Kahn K, Tobacman J. The appropriateness of coronary artery bypass
graft surgery in academic medical centers. Annals of Internal Medicine. 125(1):8-18,
1996.
68. Matchar DB, Samsa GP, Cohen SJ. Should we just let the anticoagulation service do
it? The conundrum of anticoagulation for atrial fibrillation. Journal of General Internal
Medicine. 11(12):768-770, 1996.
69. McCrory DC, Matchar DB. Stroke prevention: The emerging strategies. Hospital
Practice. 31(3):123-&, 1996.
70. Mitchell JB, Ballard DJ, Whisnant JP, Ammering CJ, Matchar DB, Samsa GP. Using
physician claims to identify postoperative complications of carotid endarterectomy.
Health Services Research. 31(2):141-152, 1996.
71. Mitchell JB, Ballard DJ, Whisnant JP, Ammering CJ, Samsa GP, Matchar DB. What
role do neurologists play in determining the costs and outcomes of stroke patients?
Stroke. 27(11):1937-1943, 1996.
72. Oddone E, Matchar DB, Goldstein L, Prichett E. Stroke prevention in an
asymptomatic patient. Journal of Clinical Outcomes Management. 3:23-35, 1996.
73. Benesch C, Witter DM, Wilder AL, Duncan PW, Samsa GP, Matchar DB. Inaccuracy
of the international classification of diseases (ICD-9-CM) in identifying the diagnosis
of ischemic cerebrovascular disease. Neurology. 49(3):660-664, 1997.
74. Bonito AJ, Samsa GP, Akin DR, Matchar DB. Use of a non-monetary incentive to
improve physician responses to a mail survey. Academic Medicine. 72(1):73-73,
1997.
75. Duncan PW, Samsa GP, Weinberger M, Goldstein LB, Bonito A, Witter DM, Enarson
C, Matchar D. Health status of individuals with mild stroke. Stroke. 28(4):740-745,
1997.
76. Goldstein LB, Farmer A, Matchar DB. Primary care physician-reported secondary
and tertiary stroke prevention practices - a comparison between the United States
and the United Kingdom. Stroke. 28(4):746-751, 1997.
77. Matchar DB. Current treatment of atrial fibrillation in the United States and the
potential for reduction in stroke. Cardiovascular Reviews & Reports. 8:16-29, 1997.
78. Matchar DB, McCrory DC, Bennett CL. Treatment considerations for persons with
metastatic prostate cancer: Survival versus out-of-pocket costs. Urology. 49(2):218-
224, 1997.
79. Matchar DB, Oddone EZ, McCrory DC, Goldstein LB, Landsman PB, Samsa G,
Brook RH, Kamberg C, Hilborne L, Leape L, Horner R. Influence of projected
complication rates on estimated appropriate use rates for carotid endarterectomy.
Health Services Research. 32(3): 325-342,1997.
80. Matchar DB, Samsa GP, Matthews JR, Ancukiewicz M, Parmigiani G, Hasselblad V,
Wolf PA, Dagostino RB, Lipscomb J. The stroke prevention policy model: Linking
evidence and clinical decisions. Annals of Internal Medicine. 127(8):704-711, 1997.
81. Parmigiani G, Samsa GP, Ancukiewicz M, Lipscomb J, Hasselblad V, Matchar DB.
Assessing uncertainty in cost-effectiveness analyses: application to a complex
decision model. Medical Decision Making. 17:390-401, 1997.
82. Samsa GP, Cohen SJ, Goldstein LB, Bonito AJ, Duncan PW, Enarson C, DeFriese
GH, Horner RD, Matchar DB. Knowledge of risk among patients at increased risk for
stroke. Stroke. 28(5):916-921,1997.

83. Biller J, Feinberg WM, Castaldo JE, Whittemore AD, Harbaugh RE, Dempsey RJ,
Caplan LR, Kresowik TF, Matchar DB, Toole JF, Easton JD, Adams HP, Brass LM,
Hobson RW, Brott TG, Sternau L. Guidelines for carotid endarterectomy - a
statement for healthcare professionals from a special writing group of the Stroke
Council, American Heart Association. Stroke. 29(2):554-562, 1998 and Circulation.
97:501-509, 1998.
84. Goldstein L, Cohen SJ, Matchar DB, Bonito AJ, Samsa GP. Physician-reported
readiness to change stroke prevention practices: implications for educational
programs. Stroke and Cerebrovascular Disease. 7(5):358-363, 1998.
85. Goldstein LB, Samsa GP, Matchar DB, Oddone EZ. Multicenter review of
preoperative risk factors for endarterectomy for asymptomatic carotid artery stenosis.
Stroke. 29(4):750-753, 1998.
86. Lipscomb J, Ancukiewicz M, Parmigiani G, Hasselblad V, Samsa G, Matchar DB.
Predicating the cost of illness: a comparison of alternative models applied to stroke.
Medical Decision Making. 18(2 Suppl):S39-S56, 1998.
87. Matchar DB. The value of stroke prevention and treatment. Neurology. 51(3):S31-
S35, 1998.
88. Naylor CD, Jadad AR, Graham D, Matchar D, Sibbald WJ, Hux J. The Ontario Health
Care Evaluation Network and the Critical Care Research Network as vehicles for
research transfer. Medical Decision Making. 18(1):16-18, 1998.
89. Oddone EZ, Horner RD, Diers T, Lipscomb J, McIntyre L, Cauffman C, Whittle J,
Passman LJ, Kroupa L, Heaney R, Matchar D. Understanding racial variation in the
use of carotid endarterectomy: The role of aversion to surgery. Journal of the
National Medical Association. 90(1):25-33, 1998.
90. Samsa GP, Matchar DB, Cohen SJ, Lipscomb J, Abrahamse P, McCormick M. A
seven-step model for practice–improvement research: description and application to
the managing anticoagulation services trial (MAST). New Medicine. 2:139-146,1998.
91. Samsa GP, Matchar DB, Goldstein L, Bonito A, Duncan PW, Lipscomb J, Enarson
C, Witter D, Venus P, Paul JE, Weinberger M. Utilities for major stroke: Results from
a survey preferences among persons at increased risk for stroke. American Heart
Journal. 136(4):703-713, 1998.
92. Kuo RL, Aslan P, Abrahamse PH, Matchar DB, Preminger GM. Incorporation of
patient preferences in the treatment of upper urinary tract calculi: A decision
analytical view. Journal of Urology. 162(6):1913-1918, 1999.
93. Matchar DB, Samsa GP. The role of evidence reports in evidence-based medicine: a
mechanism for linking scientific evidence and practice improvement. Joint
Commission Journal on Quality Improvement. 25:522-528,1999.
94. Matchar DB, Samsa GP. Using outcomes data to identify best medical practice: The
role of policy models. Hepatology. 29(6):36S-39S,1999.
95. McCrory DC, Matchar DB, Bastian L, Datta S, Hasselblad V, Myers E, Nanda K.
Evaluation of cervical cytology. Evidence Report/Technology Assessment Number 5.
(Prepared by Duke University under Contract No. 290-97-0014.). AHCPR Publication
No. 99-E010. Agency for Health Care Policy and Research, Rockville, MD, January
1999. Available at
http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=hstat1.chapter.6794.
96. Oddone EZ, Horner RD, Sloane R, McIntyre L, Ward A, Whittle J, Passman LJ,
Kroupa L, Heaney R, Diem S, Matchar D. Race, presenting signs and symptoms,
use of carotid artery imaging, and appropriateness of carotid endarterectomy. Stroke.
30(7):1350-1356, 1999.
97. Samsa G, Edelman D, Rothman ML, Williams GR, Lipscomb J, Matchar D.
Determining clinically important differences in health status measures - a general

approach with illustration to the Health Utilities Index Mark II. Pharmacoeconomics.
15(2):141-155,1999.
98. Samsa GP, Bian J, Lipscomb J, Matchar DB. Epidemiology of recurrent cerebral
infarction - a Medicare claims-based comparison of first and recurrent strokes on 2year
survival and cost. Stroke. 30(2):338-349,1999.
99. Samsa GP, Reutter RA, Parmigiani G, Ancukiewicz M, Abrahamse P, Lipscomb J,
Matchar DB. Performing cost-effectiveness analysis by integrating randomized trial
data with a comprehensive decision model: Application to treatment of acute
ischemic stroke. Journal of Clinical Epidemiology. 52(3):259-271,1999.
100. Williams GR, Jiang JG, Matchar DB, Samsa GP. Incidence and occurrence of total
(first-ever and recurrent) stroke. Stroke. 30(12):2523-2528,1999.
101. Bosworth HB, Horner RD, Edwards LJ, Matchar DB, Team VAS. Depression and
other determinants of values placed on current health state by stroke patients
evidence from the va acute stroke (VAST) study. Stroke. 31(11):2603-2609, 2000.
102. Goldstein LB, Bian J, Samsa GP, Bonito AJ, Lux LJ, Matchar DB. New transient
ischemic attack and stroke - outpatient management by primary care physicians.
Archives of Internal Medicine. 160(19):2941-2946, 2000.
103. Jones MR, Horner RD, Edwards LJ, Hoff J, Armstrong SB, Smith-Hammond CA,
Matchar DB, Oddone EZ. Racial variation in initial stroke severity. Stroke. 31(3):563-
567, 2000.
104. Krumholz HM, Brass LM, Every NR, Spertus JA, Bazzarre T, Cohen DJ, Hlatky MA,
Peterson ED, Radford MJ, Weintraub WS, Cannon CP, Ellerbeck EF, McNeil BJ,
Ryan TJ, Smith SC, Baker DW, Ashton CM, Dunbar SB, Friesinger GC, Havranek
EP, Konstam M, Ordin DL, Pina IL, Pitt B, DeLong ER, Eagle RA, Normand SL, Mark
DB, McAllister BD, Thomas JW, Duncan PW, Goldstein LB, Gorelick PB, Hinchey
JA, Matchar DB, Nilasena D, Wennberg D, Williams LS, Wolf PA, Quality Care
Outcomes Res CVDS. Measuring and improving quality of care - a report from the
American Heart Association/American College of Cardiology First Scientific Forum
on Assessment of Healthcare Quality in Cardiovascular Disease and Stroke. Stroke.
31(4):1002-1012, 2000.
105. Matchar DB. Treating QALYS with a heavy dose of social values - is the cure worth
the cost? Medical Care. 38(9): 889-891, 2000.
106. Matchar DB, McCrory DC, Gray RN. Toward evidence-based management of
migraine. JAMA-Journal of the American Medical Association. 284(20): 2640-2641,
2000.
107. Matchar DB, Samsa GP, Cohen SJ, Oddone EZ. Community impact of
anticoagulation services: rationale and design of the managing anticoagulation
services trial (MAST). Journal of Thrombosis and Thrombolysis. 9 (Suppl 1):S7-S11,
2000.
108. McCrory DC, Brown CB, Gray RN, Goslin RE, Kolimaga JT, MacIntyre NR, Oddone
EZ, Matchar DB. Management of acute exacerbations of chronic obstructive
pulmonary disease. Evidence Report/Technology Assessment Number 19.
(Prepared by Duke Evidence-based Practice Center, Contract No. 290-97-0014).
AHRQ Publication No. 01-E003. Agency for Healthcare Research and Quality,
Rockville MD, September 2000. Available at
http://www.ahrq.gov/clinic/evrptfiles.htm#copd.
109. Mitchell JB, Ballard DJ, Matchar DB, Whisnant JP, Samsa GP. Racial variation in
treatment for transient ischemic attacks: Impact of participation by neurologists.
Health Services Research. 34(7):1413-1428, 2000.

110. Myers ER, McCrory DC, Nanda K, Bastian L, Matchar DB. Mathematical model for
the natural history of human papillomavirus infection and cervical carcinogenesis.
American Journal of Epidemiology. 151(12):1158-1171, 2000.
111. Myers ER, McCrory DC, Subramanian S, McCall N, Nanda K, Datta S, Matchar DB.
Setting the target for a better cervical screening test: Characteristics of a costeffective
test for cervical neoplasia screening. Obstetrics and Gynecology. 96(5):645-
652, 2000.
112. Nanda K, McCrory DC, Myers ER, Bastian LA, Hasselblad V, Hickey JD, Matchar
DB. Accuracy of the papanicolaou test in screening for and follow-up of cervical
cytologic abnormalities: A systematic review. Annals of Internal Medicine.
132(10):810-819, 2000.
113. Oddone E, Booss J, Brass LM, Coull B, Goldstein L, Gorelick P, Horner R, Matchar
DB, Provenzale J, Kaplan L. Acute stroke management in the VA: a toolbox to assist
patient care. Federal Practitioner. 17:40-58, 2000.
114. Rutschmann OT, Matchar DB. Economics of low-molecular weight heparins.
American Journal of Managed Care. 6(20):S1054-S1065, 2000.
115. Samsa G, Matchar D. Can continuous quality improvement be assessed using
randomized trials? Health Services Research. 35(3):687-700, 2000.
116. Samsa GP, Matchar DB. Relationship between test frequency and outcomes of
anticoagulation: A literature review and commentary with implications for the design
of randomized trials of patient self-management. Journal of Thrombosis and
Thrombolysis. 9(3):283-292, 2000.
117. Samsa GP, Matchar DB, Goldstein LB, Bonito AJ, Lux LJ, Witter DM, Bian J. Quality
of anticoagulation management among patients with atrial fibrillation - results of a
review of medical records from 2 communities. Archives of Internal Medicine.
160(7):967-973, 2000.
118. Dalen JE, Hirsh J, Guyatt GH. Sixth ACCP consensus conference on antithrombotic
therapy: managing oral anticoagulant therapy. Quick Reference Guide. American
College of Physicians, Northbrook IL, January 2001. Available at
http://www.chestnet.org/downloads/guidelines/antithrombotic/qrg.pdf.
119. Ansell J, Hirsh J, Dalen J, Bussey H, Anderson D, Poller L, Jacobson A, Deykin D,
Matchar D. Managing oral anticoagulant therapy. Chest. 119(1):22S-38S, 2001.
120. Goldstein LB, Jones MR, Matchar DB, Edwards LJ, Hoff J, Chilukuri V, Armstrong
SB, Horner RD. Improving the reliability of stroke subgroup classification using the
trial of ORG 10172 in acute stroke treatment (TOAST) criteria. Stroke. 32(5):1091-
1096, 2001.
121. Matchar DB, Kulasingam SL, McCrory DC, Patwardhan MD, Rutschmann OT,
Samsa GP, Schemechel DE. Use of positron emission tomography and other
neuroimaging techniques in the diagnosis and management of Alzheimer's disease
and dementia. Technology Assessment Task Order Number 7 (Prepared by Duke
Evidence-base Practice Center, Contract No. 290-97-0014). Agency for Healthcare
Research and Quality, Rockville MD, December 2001. Available at
http://www.cms.hhs.gov/coverage/download/8b3-ww3.pdf.
122. Matchar DB, Myers ER, Barber MW, Couchman GM, Datta S, Gustilo-Ashby T,
Kolimag JT, McCrocry DC. Management of uterine fibroids. Evidence
Report/Technology Assessment Number 34. (Prepared by Duke Evidence-based
Practice Center under Contract No. 290-97-0014). AHRQ Publication No. 01-E051..
Agency for Healthcare Research and Quality, Rockville, MD, January 2001.
Available at
http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=hstat1.chapter.47755(volume I) and
http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=hstat1.chapter.48739(volume II).

123. McCrory DC, Samsa GP, Hamilton BB, Govert JA, Matchar DB, Goslin, RE,
Kolimaga JT. Treatment of pulmonary disease following cervical spinal cord injury.
Evidence Report/Technology Assessment Number 27. (Prepared by the Duke
Evidence-based Practice Center under Contract No. 290-97-0014). AHRQ
Publication No. 01-E014. Agency for Healthcare Research and Quality, Rockville,
MD, June 2001. Available at
http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=hstat1.chapter.38295.
124. Samsa GP, Matchar DB. Have randomized controlled trials of neuroprotective drugs
been underpowered? An illustration of three statistical principles. Stroke. 32(3):669-
674, 2001.
125. Lee PY, Matchar DB, Clements DA, Huber J, Hamilton JD, Peterson ED. Economic
analysis of influenza vaccination and antiviral treatment for healthy working adults.
Annals of Internal Medicine. 137(4):225-231, 2002.
126. Matchar DB, Samsa GP, Cohen SJ, Oddone EZ, Jurgelski AE. Improving the quality
of anticoagulation of patients with atrial fibrillation in managed care organizations:
Results of the Managing Anticoagulation Services Trial. American Journal of
Medicine. 113(1):42-51, 2002.
127. McCrory DC, Klassen P, Rutschmann OT, Coladonato JA, Yancy WSJr, Reddan DN,
Gray RN, Owen WF, Shurr EG, Matchar DB. Appropriate patient preparation for
Renal Replacement Therapy. Evidence Report/Final Report. (Prepared by the Duke
Evidence-based Practice Center and Duke Center for Clinical Health Policy
Research). Rockville, MD: Renal Physicians Association; April 2002. Available at
http://www.renalmd.org/publications/downloads/FinalEvReportandTables.pdf.
128. Myers ER, Barber MD, Gustilo-Ashby T, Couchman G, Matchar DB, McCrory DC.
Management of uterine leiomyomata: What do we really know? Obstetrics and
Gynecology. 100(1):8-17, 2002.
129. Myers ER, Blumrick R, Christian AL, Datta S, Gray RN, Kolimaga JT, Livingston E,
Lukes A, Matchar DB, McCrory DC. Management of prolonged pregnancy. Evidence
Report/Technology Assessment Number 53. (Prepared by Duke Evidence-based
Practice Center under Contract No. 290-97-0014). AHRQ Publication No. 02-E012.
Agency for Healthcare Research and Quality, Rockville, MD, March 2002. Available
at http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=hstat1.chapter.102647.
130. Rutschmann OT, Matchar DB. Usefulness of positron emission tomography in
evaluating dementia. JAMA-Journal of the American Medical Association.
287(8):985-986, 2002.
131. Rutschmann OT, McCrory DC, Matchar DB, Immunization Panel Multiple S.
Immunization and ms - a summary of published evidence and recommendations.
Neurology. 59(12):1837-1843, 2002.
132. Samsa G, Oddone EZ, Horner R, Daley J, Henderson W, Matchar DB. To what
extent should quality of care decisions be based on health outcomes data?
Application to carotid endarterectomy. Stroke. 33(12):2944-2949, 2002.
133. Samsa GP, Govert J, Matchar DB, McCrory DC. Use of data from nonrandomized
trial designs in evidence reports: An application to treatment of pulmonary disease
following spinal cord injury. Journal of Rehabilitation Research and Development.
39(1):41-52, 2002.
134. Samsa GP, Matchar DB, Phillips DL, McGrann J. Which approach to anticoagulation
management is best?: Illustration of an interactive mathematical model to support
informed decision making. Journal of Thrombosis and Thrombolysis. 14(2): 103-
111,2002.

135. Samsa GP, Matchar DB, Williams GR, Levy DE, participants S. Cost-effectiveness of
ancrod treatment of acute ischaemic stroke: Results from the stroke treatment with
ancrod trial (STAT). Journal of Evaluation in Clinical Practice. 8(1):61-70, 2002.
136. Shaffer DN, Datta SK, Matchar DB. Cost-effectiveness of abbreviated regimens for
helicobactor pylori eradication in peptic ulcer disease. Journal of Clinical Outcomes
Management. 9:71-78, 2002.
137. Whellan DJ, Cohen EJ, Matchar DB, Califf RM. Disease management in healthcare
organizations: Results of in-depth interviews with disease management decision
makers. American Journal of Managed Care. 8(7): 633-641,2002.
138. Abernethy AP, Samsa GP, Matchar DB. A clinical decision and economic analysis
model of cancer pain management. American Journal of Managed Care. 9(10):651-
664,2003.
139. Bian J, Oddone EZ, Samsa GP, Lipscomb J, Matchar DB. Racial differences in
survival post cerebral infarction among the elderly. Neurology. 60(2):285-290, 2003.
140. Colon-Emeric CS, Datta SK, Matchar DB. An economic analysis of external hip
protector use in ambulatory nursing facility residents. Age and Ageing. 32(1):47-52,
2003.
141. Goldstein LB, Matchar DB, Hoff-Lindquist J, Samsa GP, Horner RD. Va stroke study
- neurologist care is associated with increased testing but improved outcomes.
Neurology. 61(6):792-796 2003.
142. Goldstein LB, Matchar DB, Hoff-Lindquist J, Samsa GP, Horner RD. Veterans
administration acute stroke (VAST) study - lack of race/ethnic-based differences in
utilization of stroke-related procedures or services. Stroke. 34(4): 999-1003, 2003.
143. Harpole LH, Samsa GP, Jurgelski AE, Shipley JL, Bernstein A, Matchar DB.
Headache management program improves outcome for chronic headache.
Headache. 43(7):715-724, 2003.
144. Horner RD, Swanson JW, Bosworth HB, Matchar DB, Team VS. Effects of race and
poverty on the process and outcome of inpatient rehabilitation services among stroke
patients. Stroke. 34(4):1027-1031, 2003.
145. Kulasingam SL, Samsa GP, Zarin DA, Rutschmann OT, Patwardhan MB, McCrory
DC, Schmechel DE, Matchar DB. When should functional neuroimaging techniques
be used in the diagnosis and management of Alzheimer's dementia? A decision
analysis. Value in Health. 6(5):542-550, 2003.
146. Matchar DB. Do anticoagulation management services improve care? Implications
of the Managing Anticoagulation Services Trial. Cardiac Electrophysiology Review.
7:379-381, 2003.
147. Matchar DB. Health policy in stroke: Translating what we know into what we do.
Stroke. 34(2):370-371, 2003.
148. Matchar DB, Patwardhan MB, Samsa GP. Making evidence-based practice
improvement more than a comforting sentiment. American Journal of Medicine.
115(5):407-409, 2003.
149. Parmigiani G, Ashih HW, Samsa GR, Duncan PW, Lai SM, Matchar DB. Crosscalibration
of stroke disability measures: Bayesian analysis of longitudinal ordinal
categorical data using negative dependence. Journal of the American Statistical
Association. 98(462): 273-281, 2003.
150. Bushnell CD, Matchar DB. Pharmacoeconomics of atrial fibrillation and stroke
prevention. American Journal of Managed Care. 10:S66-S71, 2004.
151. Dodick D, Lipton RB, Martin V, Papademetriou V, Rosamond W,
MaassenVanDenBrink A, Loutfi H, Welch KM, Goadsby PJ, Hahn S, Hutchinson S,
Matchar D, Silberstein S, Smith TR, Purdy RA, Saiers J, Triptan Cardiovascular

Safety E. Consensus statement: Cardiovascular safety profile of triptans (5-ht1b/1d
agonists) in the acute treatment of migraine. Headache. 44(5):414-425, 2004.
152. Goldstein LB, Matchar DB, Hoff-Lindquist J, Samsa GP, Horner RD. Veterans
Administration Acute Stroke (VASt) Study: Neurologist care is associated with
increased testing but improved outcomes. Neurology. 62:1914-1915, 2004.
153. Goldstein LB, Samsa GP, Matchar DB, Horner RD. Charlson index comorbidity
adjustment for ischemic stroke outcome studies. Stroke. 35(8):1941-1945, 2004.
154. James A, Matchar DB, Myers ER. Testing for von Willebrand disease in women with
menorrhagia: A systematic review. Obstetrics and Gynecology. 104(2): 381-388,
2004.
155. Matchar DB. What can models teach us about stroke treatment? Sorting out the
missing bits. Stroke. 35(6):1497-1498, 2004.
156. Matchar DB, Kulasingam SL, Havrilesky L, Mann LO, Myers ER, McCrory DC,
Patwardhan M, Prosnitz R. Positron emission testing for six cancers (brain, cervical,
small cell lung, ovarian, pancreatic and testicular). (Prepared by the Duke University
under Contract No. 290-02-0025). Task Order No. 0. Rockville, MD: Agency for
Health Care Policy and Research. Available at
http://www.cms.hhs.gov/mcd/index_list.asp?list_type=tech. March 2004
157. McCrory DC, Pompeii LA, Skeen MB, Moon SD, Gray RN, Kolimaga JT, Matchar
DB. Criteria to determine disability related to multiple sclerosis. Evidence
Report/Technology Assessment Number 100. (Prepared by Duke Evidence-based
Practice Center under contract no. 290-02-0025). AHRQ Publication No. 04-E019-2.
Rockville, MD: Agency for Healthcare Research and Quality. May 2004.
158. Orlando LA, Kulasingam SL, Matchar DB. Meta-analysis: The detection of pancreatic
malignancy with positron emission tomography. Alimentary Pharmacology &
Therapeutics. 20(10):1063-1070, 2004.
159. Orlando LA, Matchar DB. When to stress over triptans: A Markov analysis of
cardiovascular risk in migraine treatment. Headache. 44(7): 652-660, 2004.
160. Patwardhan MB, McCrory DC, Matchar DB, Samsa GP, Rutschmann OT. Alzheimer
disease: Operating characteristics of PET - a meta-analysis. Radiology. 231(1):73-
80, 2004.
161. Rudd AG, Matchar DB. Health policy and outcome research in stroke. Stroke.
35(2):397-400, 2004.
162. Samsa GP, Matchar DB. How strong is the relationship between functional status
and quality of life among persons with stroke? Journal of Rehabilitation Research
and Development. 41(3A): 279-282, 2004.
163. Samsa GP, Matchar DB, Dolor RJ, Wiklund I, Hedner E, Wygant G, Hauch O,
Marple CB, Edwards R. A new instrument for measuring anticoagulation-related
quality of life: development and preliminary validation. Health and Quality of Life
Outcomes. 2:22. Available at http://www.hqlo.com/content/pdf/1477-7525-2-22.pdf.
2004
164. Harpole LH, Samsa GP, Matchar DB, Silberstein SD, Blumenfeld A, Jurgelski AE.
Burden of illness and satisfaction with care among patients with headache seen in a
primary care setting. Headache. 45(8):1048-1055, 2005.
165. Havrilesky LJ, Kulasingam SL, Matchar DB, Myers ER. FDG-PET for management of
cervical and ovarian cancer. Gynecologic Oncology. 97(1):183-191, 2005.
166. Liao L, Sarria-Santamera A, Matchar DB, Huntington A, Lin S, Whellan DJ, Kong DF.
Meta-analysis of survival and relief of angina pectoris after transmyocardial
revascularization. American Journal of Cardiology. 95(10):1243-1245, 2005.
167. Matchar DB, Jacobson AK, Edson RG, Lavori PW, Ansell JE, Ezekowitz MD, Rickles
F, Fiore L, Boardman K, Phibbs C, Fihn SD, Vertrees JE, Dolor R. The impact of

patient self-testing of prothrombin time for managing anticoagulation: Rationale and
design of VA cooperative study #481 - The Home INR Study (THINRS). Journal of
Thrombosis and Thrombolysis. 19(3):163-172, 2005.
168. Matchar DB, Rosenberg JH, Carter S. Guidelines for a new era in the care of
patients with epilepsy: first steps in responding to the challenge. Postgraduate
Medicine. 118:18-21, 2005.
169. Matchar DB, Rudd AG. Health policy and outcomes research 2004. Stroke.
36(2):225-227, 2005.
170. Matchar DB, Samsa GP. How can modeling best contribute to the assessment of
secondary stroke prevention strategies? American Journal of Medicine. 118(2):198-
199, 2005.
171. Matchar DB, Samsa GP, Liu S. Cost-effectiveness of antiplatelet agents in
secondary stroke prevention: The limits of certainty. Value in Health. 8(5):572-580,
2005.
172. Matchar DB, Westermann-Clark EV, McCrory DC, Patwardhan M, Samsa G,
Kulasingam S, Myers E, Sarria-Santamera A, Lee A, Gray R, Liu K. Dissemination of
evidence-based practice center reports. Annals of Internal Medicine. 142(12):1120-
1125, 2005.
173. Orlando LA, Matchar DB. Chronic kidney disease: Relationship of nephrologist
involvement and disease course. Journal of Investigative Medicine. 53(1):340, 2005.
174. Patwardhan MB, Matchar DB, Samsa GP, McCrory DC, Williams RG, Li TT. Cost of
multiple sclerosis by level of disability: A review of literature. Multiple Sclerosis.
11(2):232-239, 2005.
175. Samsa GP, Matchar DB, Harnett J, Wilson J. A cost-minimization analysis
comparing azithromycin-based and levofloxacin-based protocols for the treatment of
patients hospitalized with community-acquired pneumonia - results from the CAP-in
trial. Chest. 128(5):3246-3254, 2005.
176. Amin MS, Matchar DB, Wood MA, Ellenbogen KA. Management of recalled
pacemakers and implantable cardioverter-defibrillators - a decision analysis model.
JAMA-Journal of the American Medical Association. 296(4):412-420, 2006.
177. Bian J, Dow WH, Matchar DB. Medicare hmo penetration and mortality outcomes of
ischemic stroke. American Journal of Managed Care. 12(1):58-64, 2006.
178. Kulasingam SL, Samsa GP, Matchar DB. Linking dementia research to policy: an
example using fluorodeoxyglucose positron emission tomography for the diagnosis
of Alzheimer's dementia and mild cognitive impairment. American Journal of
Alzheimers Disease and Other Dementia. 21(2):73-8, 2006.
179. Matchar DB, Patwardhan MB, Samsa GP, Haley WE. Facilitated process
improvement: An approach to the seamless linkage between evidence and practice
in CKD. American Journal of Kidney Diseases. 47(3):528-538, 2006.
180. Patwardhan MB, Samsa GP, Lipton RB, Matchar DB. Changing physician
knowledge, attitudes, and beliefs about migraine: Evaluation of a new educational
intervention. Headache. 46(5):732-741, 2006.
181. Orlando LA, Owen WF, Matchar DB: Relationship between nephrologist care and
progression of chronic kidney disease. North Carolina Medical Journal. 68(1):9-16,
2007.
182. Patwardhan MB, Sarria-Santamera A, Matchar DB. Improving the process of
developing technical reports for health care decision makers: Using the Theory of
Constraints in the Evidence-based Practice Centers. International Journal of
Technology Assessment in Health Care. 22(1):26-32, 2006.
183. Sarria-Santamera A, Matchar DB, Westermann-Clark E, Patwardhan MB. Evidencebased
practice center network and health technology assessment in the United

States: Bridging the cultural gap. International Journal of Technology Assessment in
Health Care. 22(1):33-38, 2006.
184. Eisenstein EL, Anstrom KJ, Kong DF, Shaw LK, Tuttle RH, Mark DB, Kramer JM,
Harrington RA, Matchar DB, Kandzari DE, Peterson ED, Schulman KA, Califf RM.
Clopidogrel use and long-term clinical outcomes after drug-eluting stent implantation.
JAMA-Journal of the American Medical Association. 297(2):159-168, 2007.
185. Matchar DB, McCrory DC, Orlando LA, Patel MR, Patel UD, Patwardhan MB,
Powers B, Samsa GP, Gray RN. Comparative effectiveness of angiotensinconverting
enzyme inhibitors (ACEIs) and angiotensin II receptor antagonists (ARBs)
for treating essential hypertension. Comparative Effectiveness Review No. 10.
(Prepared by Duke Evidence-based Practice Center under Contract No. 290-02-
0025.) Rockville, MD: Agency for Healthcare Research and Quality. Available at:
www.effectivehealthcare.ahrq.gov/reports/final.cfm. November 2007.
186. Matchar DB, Thakur M. Is genetic testing for cytochrome p450 polymorphisms ready
for implementation? American Family Physician. 76(3):348-+, 2007.
187. Matchar DB. Thakur ME. Grossman I. McCrory DC. Orlando LA. Steffens DC.
Goldstein DB. Cline KE. Gray RN. Testing for cytochrome P450 polymorphisms in
adults with non-psychotic depression treated with selective serotonin reuptake
inhibitors (SSRIs). Evidence Report/Technology Assessment. (146):1-77, 2007
188. Patel MR, Hurwitz LM, Orlando L, McCrory DC, Sanders GD, Matchar DB, Mark D.
Noninvasive imaging for coronary artery disease: A technology assessment for the
Medicare Coverage Advisory Commission. American Heart Journal. 153(2):161-174,
2007.
189. Patwardhan MB, Samsa GP, Matchar DB, Haley WE. Advanced chronic kidney
disease practice patterns among nephrologists and non-nephrologists: A database
analysis. Clinical Journal of the American Society of Nephrology. 2(2):277-283,
2007.
190. Patwardhan MB, Samsa GP, Matchar DB, Haley WE. Non-nephrologist and
nephrologist perspectives on implementing a chronic kidney disease guideline.
Journal for Healthcare Quality. In press (Web Exclusive. Vol. 29, No. 6, pp. W6-3–
W6-17. November/December 2007)
191. Thakur M, Grossman I, McCrory DC, Orlando LA, Steffens DC, Cline KE, Gray RN,
Farmer J, DeJesus G, O'Brien C, Samsa G, Goldstein DB, Matchar DB. Review of
evidence for genetic testing for cyp450 polymorphisms in management of patients
with nonpsychotic depression with selective serotonin reuptake inhibitors. Genetics
in Medicine. 9(12):826-835, 2007.
192. Anstrom KJ, Kong DF, Shaw LK, Califf RM, Kramer JM, Peterson ED, Rao SV,
Matchar DB, Mark DB, Harrington RA, Eisenstein EL. Long-term clinical outcomes
following coronary stenting. Archives of Internal Medicine. 168(15):1647-1655, 2008.
193. Dorn SD, Matchar DB. Cost-effectiveness analysis of strategies for diagnosing celiac
disease. Digestive Diseases and Sciences. 53(3):680-688, 2008.
194. Konstance RP, Eisenstein EL, Anstrom KJ, Shaw LK, Califf RM, Harrington RA,
Matchar DB, Schulman KA, Kong DF. Outcomes of second revascularization
procedures after stent implantation. Journal of Medical Systems. 32(2):177-186,
2008.
195. Krumholz HM, Keenan PS, Brush JE, Bufalino VJ, Chernew ME, Epstein AJ,
Heidenreich PA, Ho V, Masoudi FA, Matchar DB, Normand SLT, Rumsfeld JS,
Schuur JD, Smith SC, Spertus JA, Walsh MN. Standards for measures used for
public reporting of efficiency in health care - A scientific statement from the American
Heart Association Interdisciplinary Council on Quality of Care and Outcomes

Research and the American College of Cardiology Foundation. Journal of the
American College of Cardiology. 52(18):1518-1526, 2008.
196. Matchar DB, Harpole L, Samsa GP, Jurgelski A, Lipton RB, Silberstein SD, Young
W, Kori S, Blumenfeld A. The headache management trial: A randomized study of
coordinated care. Headache. 48(9):1294-1310, 2008.
197. Matchar DB, Mark DB. Strategies for incorporating resource allocation and economic
considerations. Chest. 133(6):132S-140S, 2008.
198. Matchar DB, McCrory DC, Orlando LA, Patel MR, Patel UD, Patwardhan MB,
Powers B, Samsa GP, Gray RN. Systematic review: Comparative effectiveness of
angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers for
treating essential hypertension. Annals of Internal Medicine. 148(1):16-29, 2008.
199. Myers ER, McCrory DC, Mills AA, Price TM, Swamy GK, Tantibhedhyangkul J, Wu
JM, Matchar DB. Effectiveness of assisted reproductive technology (ART). Evid
Rep Technol Assess (Full Rep). (167):1-195, 2008
200. Patwardhan MB, Matchar DB, Samsa GP, Haley WE. Opportunities for improving
management of advanced chronic kidney disease. American Journal of Medical
Quality. 23(3):184-192, 2008.
201. Patwardhan MB, Matchar DB, Samsa GP, Haley WE. Utility of the advanced chronic
kidney disease patient management tools: Case studies. American Journal of
Medical Quality. 23(2):105-114, 2008.
202. Dolor RJ, Yancy WS, Owen WF, Matchar DB, Samsa GP, Pollak KI, Lin PH, Ard JD,
Prempeh M, McGuire HL, Batch BC, Fan W, Svetkey LP. Hypertension improvement
project (HIP): Study protocol and implementation challenges. Trials. 10:13, 2009.
PMID19245692
203. Douglas PS, Brennan JM, Anstrom KJ, Sedrakyan A, Eisenstein EL, Haque G, Dai
D, Kong DF, Hammill B, Curtis L, Matchar D, Brindis R, Peterson ED. Clinical
effectiveness of coronary stents in elderly persons results from 262,700 Medicare
patients in the American College of Cardiology-National Cardiovascular Data
Registry. Journal of the American College of Cardiology. 53(18):1629-1641, 2009.
204. Patwardhan MB, Kawamoto K, Lobach D, Patel UD, Matchar DB. Recommendations
for a clinical decision support for the management of individuals with chronic kidney
disease. Clinical Journal of the American Society of Nephrology. 4(2):273-283, 2009.
205. Svetkey LP, Pollak KI, Yancy WS, Jr., Dolor RJ, Batch BC, Samsa G, Matchar DB,
Lin PH. Hypertension improvement project. Randomized trial of quality improvement
for physicians and lifestyle modification for patients. Hypertension. 54(6):1226-1233,
2009.
206. Frick KD, Kymes SM, Lee PP, Matchar DB, Pezzullo ML, Rein DB, Taylor HR;
Vancouver economic burden of vision loss group. The cost of visual impairment:
Purposes, perspectives, and guidance. Investigative Ophthalmology & Visual
Science. 51:1801-1805, 2010.
207. Dolor RJ, Ruybalid RL, Uyeda L, Edson RG, Phibbs C, Vertrees JE, Shih MC,
Jacobson AK, Matchar DB; An evaluation of patient self-testing competency of
prothrombin time for managing anticoagulation: Pre randomization results of VA
cooperative study #481- The Home INR Study (THINRS) Journal of Thrombosis and
Thrombolysis. 30(3):263-275, 2010.
208. Patel MR, Greiner MA, DiMartino LD, Schulman KA, Duncan PW, Matchar DB,
Curtis LH. Geographic variation in carotid revascularization among Medicare
beneficiaries, 2003-2006. Archives of Internal Medicine. 17(14):1218-1225, 2010.
209. Matchar DB, Jacobson A, Dolor RJ, Edson RG, Uyeda L, Phibbs CS, Vertrees JE,
Shih MC, Holodniy M, Lavori P; Effect of home testing of international normalized
ratio on clinical events. New England Journal of Medicine. 363(17):1608-1620, 2010.

210. Mercaldi CJ, Ciarametaro M, Hahn B, Chalissery G, Reynolds MW, Sander SD,
Samsa GP, Matchar DB; Cost efficiency of anticoagulation with warfarin to prevent
stroke in medicare beneficiaries with non-valvular atrial fibrillation. Stroke. 42(1):112-
8, 2010.
211. Curtis L, Duncan PW, Matchar DB, Greiner MA, Patel MR, Schulman KA;
Geographic variation and trends in cartroid imaging among Medicare beneficiaries,
2001-2006. Circulation: Cardiovascular Quality and Outcomes. 3(6):599-606, 2010.
212. Roger VL, Go AS, Lloyd-Jones DM, Adams RJ, Berry JD, Brown TM, Carnethon MR,
Dai S, de Simone G, Ford ES, Fox CS, Fullerton HJ, Gillespie C, Greenlund KJ,
Hailpern SM, Heit JA, Ho PM, Howard VJ, Kissela BM, Kittner SJ, Lackland DT,
Lichtman JH, Lisabeth LD, Makuc DM, Marcus GM, Marelli A, Matchar DB,
McDermott MM, Meigs JB, Moy CS, Mozaffarian D, Mussolino ME, Nichol G, Paynter
NP, Rosamond WD, Sorlie PD, Stafford RS, Turan TN, Turner MB, Wong ND, Wylie-
Rosett J; Heart Disease and Stroke Statistics--2011 Update: A Report From the
American Heart Association. Circulation. 1;123(4):e18-e209, 2011.
213. Orlando LA, Belasco EJ, Patel UD, Matchar DB; The Chronic Kidney Disease Model:
A General Purpose Model of Disease Progression and Treatment. BMC Medical
Informatics and Decision Making. 11(1):41, 2011.
214. Carrasco LR, Lee VJ, Chen MI, Matchar DB, Thompson JP, Cook AR; Strategies for
antiviral stockpiling for future influenza pandemics: a global epidemic-economic
perspective. Journal of Royal Society Interface. 8(62):1307-13, 2011.
215. Atkins D, Chang S, Gartlehner G, Buckley DI, Whitlock EP, Berliner E, Matchar D;
Assessing applicability when comparing medical interventions: Agency for
Healthcare Research and Quality and the Effective Health Care Program. Journal of
Clinical Epidemiology. Epub ahead of print.
216. Setia M, Islam AM, Thompson JP, Matchar DB; Stakeholders’s perspective on
issues and challenges associated with care and treatment of aging-related cognitive
impairment disorders in Singapore. International Psychogeriatric Association. 1-12.
Epub ahead of print.
217. Heneghan C, Ward A, Matchar DB; Self-monitoring of oral anticoagulation:
systematic review and meta-analysis of individual patient data. Lancet. In Press.
Letters:
1. Matchar DB, Pauker SG. Endarterectomy in carotid-artery disease - reply. JAMA-Journal
of the American Medical Association. 258(24): 3514-3514. 1987.
2. Feussner JR, Matchar DB. Carotid endarterectomy - reply. Annals of Internal Medicine.
111(6): 540-541. 1989.
3. Feussner JR, Matchar DB. Carotid endarterectomy - response. Annals of Internal
Medicine. 111(5): 443-444. 1989.
4. Simel DL, Piscitelli J, Matchar DB. Intravenous pyelography before hysterectomy.
Annals of Internal Medicine. 3: 541. 1989.
5. Murphy DJ, Matchar DB. The utility of CPR in elderly persons - reply. JAMA-Journal of
the American Medical Association. 265(7): 866-866. 1991.
6. Simel DL, Matchar DB, Feussner JR. Chance-corrected sensitivity and specificity for 3zone
diagnostic-tests - response. Journal of Clinical Epidemiology. 45(9): 1038-
1039,1992.
7. Schapira MM, Matchar DB, Young MJ. When and whom to screen - reply. Annals of
Internal Medicine. 119(11): 1152-1152. 1993.

8. Goldstein LB, McCrory DC, Landsman PB, Samsa GP, Ancukiewicz M, Oddone EZ,
Matchar DB. Preoperative risk-factors for carotid endarterectomy - reply. Stroke. 25(10):
2097-2097. 1994.
9. Matchar DB, McCrory DC, Barnett HJ, Feussner JR. Medical-treatment for stroke
prevention (vol 121, pg 41, 1994). Annals of Internal Medicine. 121(6): 470-470. 1994.
10. Matchar DB, McCrory D, Pritchett ELC. Management of chronic asymptomatic atrial
fibrillation. Annals of Internal Medicine. 6: 466-467. 1994.
11. Matchar DB, McCrory DC, Barnett HJ, Feussner JR. Medical-treatment of stroke
prevention (vol 121, pg 41, 1994). Annals of Internal Medicine. 122(11): 885-885,1995.
12. Matchar DB. Stroke prevention guidelines - reply. Annals of Internal Medicine. 122(3):
235-236. 1995.
13. Oddone E, Blakeley D, Matchar DB. Noninvasive carotid-artery testing - reply. Annals of
Internal Medicine. 123(8): 634-634. 1995.
14. Tsevat J, Matchar DB, Wu AW. Health values of the seriously ill - response. Annals of
Internal Medicine. 124(2): 279-279. 1996.
15. Matchar DB, Samsa G, Cohen S. Should we just let the anticoagulation service do it?
Reply. Journal of General Internal Medicine. 12(4): 259-259. 1997.
16. Benesch C, Wilder AL, Witter DM, Duncan PW, Samsa GP, Matchar DB. Inaccuracy of
the icd-9-cm in identifying the diagnosis of ischemic cerebrovascular disease - reply.
Neurology. 51(3): 922-922, 1998.
17. Biller J, Castaldo JE, Whittemore AD, Harbaugh RE, Dempsey RJ, Caplan LR, Kresowik
TF, Matchar DB, Toole JF, Easton JD, Adams HP, Brass LM, Hobson RW, Brott TG,
Sternau L. Concerns regarding carotid endarterectomy guidelines - response. Stroke.
29(7): 1475-1476, 1998.
18. Oddone EZ, Horner R, Matchar DB. Racial inequity of access to carotid imaging -
response. Stroke. 30(11): 2491-2491, 1999.
Books or chapters in books:
1. Matchar DB. Decision analysis. In: Cohen HJ, ed. Introduction to Methodologies for
Clinical Research in Geriatrics (Summer Research Workshop, July 30-August 5, 1989).
New York, NY: American Geriatrics Society. 1990.
2. Matchar DB, Goldstein LB, McCrory DC, Oddone EZ, Jansen DA, Hilbourne LH, Park
RE. Carotid Endarterectomy: A literature review and ratings of appropriateness and
necessity. RAND, JRA-05.1992.
3. Matchar DB. Application of decision analysis to guideline development. In: McCormick
KA, Moore SR, Siegel RA, eds. Clinical Practice Guideline Development: Methodology
Perspectives. Rockville, MD: Agency for Health Care Policy Research. 35-40. AHCPR
Pub. No. 95-0009. 1994
4. Parmigiani G, Ancukiewicz M, Matchar DB. Decision models in clinical
recommendations development: the Stroke Prevention Policy Model. In: Berry DA,
Stangl DK, eds. Bayesian Biostatistics. New York, NY: Marcel Dekker. 207-233. 1996
5. Matchar DB, Pauk JS, Lipscomb J. A health policy perspective on carotid
endarterectomy: cost, effectiveness, and cost-effectiveness. In: Moore WS, ed. Surgery
for Cerebrovascular Disease. New York, NY: Churchill Livingstone. 680-689. 1987
6. Matchar DB, Abrahamse P, Lipscomb J, Samsa G. Policy perspective on acute stroke
treatment. In: Shoaib A, Goldstein LB, eds. Management of Acute Stroke (Neurological
Disease and Therapy). New York, NY: Marcel Dekker. 1-14.1999
7. Matchar DB. Linking health policy modeling with health policy formation and

implementation. In: Chapman GB, Sonnenberg FA, eds. Decision Making in Health
Care: Theory, Psychology, and Applications. Cambridge, UK: Cambridge University
Press.145-157. 2000
8. Matchar DB, Samsa GP. Frequency of testing and therapeutic effectiveness. In: Ansell
JE, Oertel LB, Wittkowsky AK, eds. Managing Oral Anticoagulation Therapy: Clinical
and Operational Guidelines. Gaithersburg, MD: Aspen Publishers. 1-5. 2002
9. Matchar DB. Improving Adherence with Clinical Guidelines. In: Bosworth HB., Oddone
EZ., Weinberger M, eds. Patient treatment adherence: Concepts, interventions, and
measurement. Mahwah, NJ: Lawrence Erlbaum Associates.
10. Matchar DB, Orlando LA. The relationship between test and outcome. In: Price CP,
Christenson RH, eds. Evidence-based Laboratory Medicine. Washington, DC: AACC
Press. 53-66. 2007
11. Committee on Treatment of Posttraumatic Stress Disorder. Institute of Medicine (IOM).
Treatment of Posttraumatic Stress Disorder: An assessment of the evidence. The
National Academies Press. 2007.
12. Iris Grossman, Mugdha Thakur, and Matchar DB. Chapter 32: In: Case Studies:
Assessing the use of genetic information in practice for specific diseases. Cytochrome
P450 testing in the treatment of depression. Oxford, UK: Oxford University Press:
Human Genome Epidemiology. 2007.
13. Matchar DB. Chapter 1: Patient Registries. Registries for evaluating patient outcomes: A
user’s guide second edition. Rockville, MD: Agency for Healthcare Research and
Quality. 9-19. 2010.
Books or chapters in books in Review:
1. Matchar DB, editor. Evaluation of Medical Tests.
Society Memberships:
1984 - American College of Physicians
Fellow (1990)
Advisor, Health and Public Policy (1986)
1984 - Society for General Internal Medicine
Nominating Committee (1989)
President, Southern Section (1988)
Chairman, Abstract Review Committee (1991)
1984 Sydenham Society
1987 - 1990 American Federation for Clinical Research

1985 - Society of Medical Decision Making
Editorial Board (1990)
Chairman, 1993 Annual Meeting
Board of Trustees (1994)
Vice President (1996)
1995 American Academy of Neurology, Headache and Facial Pain
1997 - American Heart Association
Stroke Council
Fellow
1999 - International Society for Pharmacoeconomics and Outcomes Research
2003 - American Headache Society
2010 - 2011 Gerontological Society of America
National/International Committees:
1986 Hospital Based Home Care Advisory Committee
1989 Academic Medical Centers Consortium, Committee of Health Services Research
Liaison (AMCC-CHSRL)
1990 Task Force, Center for Youth
1991 Journal of Health Public Policy and Law Management Committee
1992 North Carolina Cervical Cancer Task Force
1994 Breast Cancer Among Women Veterans: Pilot/Feasibility Study (VAHSR SDR #92-006)
Advisory Committee
1996 North Carolina Stroke Prevention Committee
1996 Value Measurement Systems Oversight Committee
1996 Chair, National Cancer Institute of Canada Study Section
1998 Representative to G 7 Healthcare Project, Evidence and Effectiveness
1998 - ACP Representative, Headache Guideline Consortium
1998 - VA Stroke Quality Enhancement Research Initiative (QUERI) Operations Committee

1999 - National Institute for Neurological Disorders and Stroke
Progress Review Group (2001)
Advisor (2003)
2000 - 2003 Improving Chronic Illness Care, Robert Wood Johnson Foundation National Advisory
Committee
2002 - Advisory Board, VA Rehabilitation Outcomes Research Center
2002 - Advisory Board, American Headache Society
2003 - Advisory Panel, Disease-Specific Care Stroke Performance Measure, Joint
Commission on Accreditation of Healthcare Organization
2004 - National Integrated Stroke Treatment Education Program Steering Committee
2005 - 2006 Institute of Medicine (IOM) Committee on the Gulf War and Health: Literature Review
2005 Advisory Board, National Health Care Survey Forum at the National Center for Health
Statistics
2005
2006 – 2009
Chair, Neurovascular Coalition Carotid Stent Task Force
Coordinating Panel Representative, National Kidney Disease Education Program
(NKDEP)
2006 – 2007 Institute of Medicine (IOM), Committee on Treatment of Posttraumatic Stress Disorder,
Board on Population Health and Public Health Practice
2005 – 2007
2008 -
2008 -
2008 -
2008
(Singapore) -
2009
(Singapore) -
WHO Committee On Blood Pressure Measurement In Low Resource Settings
CDC K01 Award Program
Chairman, Executive Committee, Stroke Quality Enhancement Research Initiative,
Department of Veterans Affairs
Search Committee, Duke Global Health Institute
SingHealth HR Platforms Workgroup (for Clinical Research Manpower)
Chairman, SingHealth Review Committee for Health Services Research Fund
Committee for MOH on the Electronic Health Record
Planning Committee for the Health Technology Assessment International Meeting for
Singapore 2009
Duke-NUS Centre of Quantitative Biology & Medicine (CQBM) Committee
Chairman, SingHealth Duke-NUS Scientific Congress 2010
Adviser, National Trauma Registry (NTR) Advisory Committee (NTRAC)

2010
(Singapore) -
2011
(Singapore) -
Member, National Medical Research Council (NMRC) Local Review Panel
Chairman, SingHealth Grant Review Committee (Health Services Research)
Consultant and Scientific Adviser, Singapore Clinical Research Institute
Member, International Advisory Committee (MOH Health Services Research
Competitive Research Grant.
Member, Duke-NUS Emerging Infectious Diseases Program Search Committee
Member, Specialists Accreditation Board (SAB) Research Committee
Chairperson, Research Sub-Group for the National Strategy for Palliative Care Project
Member, Workgroup for the National Strategy for Palliative Care Project
Member, Lien Centre for Palliative Care Scientific Advisory Board
Member, Project SCOPE Consultative Committee (PSCC) of the Self-Care on Health of
Older People in Singapore (Project Scope).
Editorial Boards and Consultancies:
1989 American Cancer Society Workshop on Clinical Trial
1990 Combined Medical Specialties Societies
1991 Consultant, Asymptomatic Carotid Atherosclerosis Study (ACAS)
1991- Consultant, Pfizer Pharmaceuticals
1991 Contractor, Elective Surgery Algorithm Project (ESAP), Consultant to HCFA
1993 Consultant, Thomas Jefferson Health Policy Institute
1993 Centers for Disease Control and Prevention (CDC)
1994 Consultant, Janssen Research Foundation
1995 Cardiovascular Medical Advisory Board, Medco Containment Services
1995 Consultant, DuPont Pharmaceutical
1995 Consultant, Wyeth-Ayerst Research

1996 - 1998
Editorial Board, Synapse Publishing
Senior Editor (1997)
1997 Consultant, Johnson & Johnson
1999 - Principal, Requisite Consulting Group, Inc
2000 - Editorial Board, American Journal of Medicine
2001 - Stroke
Health Policy/Outcomes Research, Section Editor
2001 - Editorial Board, Health Services and Outcomes Research Methodology
2001 - 2005 Editorial Board, Clinical Evidence, British Medical Journal
2003 - 2004 MI Plus Expert Panel, Center for Outcomes and Effectiveness Research and Education,
University of Alabama at Birmingham
2004 - Consultant, Roche for educational programs related to optimizing anticoagulation
management
2008 -
2008 -
2011 -
2011 -
Consultant, Boehringer Ingelheim, Atrial Fibrillation Registry Study
Editor, Diagnostic Test Guidance for the Agency for Health Care Policy and Research
Associate Editor, International Journal of System Dynamics Applications (IJSDA)
Senior Associate Editor, Health Services Research Journal
Reviewer (Journal or Organization):
1987 - Annals of Internal Medicine
1987 - Journal of the American Medical Association
1988 Journal of General Internal Medicine
1989 Journal of Gerontology: Medical Sciences
1989 Mayo Clinic Proceedings
1989 - American Journal of Medicine
1989 Journal of Clinical Epidemiology
1990 American College of Gastroenterology
1991 Health Services Research

1991 Cambridge University Press,
Ad hoc reviewer (1997, 1998)
1992 Annals of Neurology
1992 Journal of Neurological Sciences
1993 - 1997 Department of Health and Human Services, Agency for Health Care Policy and Research,
Health Care Technology Study Section
1996 Journal of Investigative Dermatology
1999 - National Institute for Neurological Disorders and Stroke Study Section
2001 - Stroke
2001- 2004 Agency for Healthcare Research and Quality, Health Research Dissemination &
Implementation Study Section
2004 - Centers for Disease Control and Prevention K01 Training Grant Program
2004 National Institutes of Health, Roadmap RFA review: "Dynamic
Assessment of Patient-Reported Chronic Disease Outcomes
2009 German-Israeli Foundation for Scientific Research and Development Genetic and
epigenetic determinants of CYP2C9 Grant
2010 The New England Journal of Medicine
Professional awards and special recognitions:
1980 Cum Laude University of Maryland School of Medicine
1980 Alpha Omega Alpha Honor Medical Society
1984 AW Mellon Fellowship in Medical Decision Sciences
1994 - Who's Who in the South and Southwest
1995 - Who's Who in America
1995 - Who’s Who in American Education

2003 - Who's Who in Medicine and Healthcare
2003 - Who's Who in Science and Engineering
2005 - Who's Who in the World
Teaching responsibilities:
1984 - 1992 Critical Appraisal of the Literature - Offered to senior medical residents
1985 - 1986 Epidemiology for Clinicians - Offered to clinical research fellows and clinical faculty
1986 - 1987 Clinical Decision Analysis - Offered to clinical research fellows and clinical faculty
1988 - 1997 Clinical Decision Analysis BMI 217 - Masters of Biometry Program
2002 - 2008 Health Economics in Clinical Research (CRTP 244) - Masters of Health Science (Clinical
Research)
2002 - 2004 Medical Practice and Health Systems - Offered to medical students (teaches 6 classes
per year)
2010 - 2011 Introduction to Health Services Research (CO5214) – Masters of Clinical Investigation
(MCI) Program
House Staff Teaching and Ward Attending:
1985 - 1993 Critical Appraisal Journal Club - one session per week
1985 - 1991 Problems in Ambulatory Care Medicine - one session per week
1985 - 2008 Ward Attending, General Internal Medicine - one month per year
Areas of research interests:
General
theme:
Clinical
research:
Formation and implementation of clinical health policy
Evaluation and treatment of patients with cerebrovascular disease and similarly
common medical disorders
Methodology: Cohort analytic studies, technology assessment, clinical decision analysis,
cost-effectiveness analysis, classification techniques, Bayesian analysis, randomized
trials for evaluation of clinical improvement strategies

Clinical Practice:
1985 - 2008 General Internal Medicine: 10%, 1 half-day session per week
Duke University Medical Center Activities:
1986 Division of General Internal Medicine Search Committee, Chief
1990 Duke University Press
1990 - Council on Aging and Human Development
1991 - 2000 Institutional Review Board, Duke University
1992 Journal of Health Politics, Policy and Law, [JHPPL] Management Board
1992 Department of Community and Family Medicine Search Committee
1992 - MHCRC for Depression in Late Life Advisory Committee
1993 - Government Resources Committee
1994 Internal Advisory Board, Exploratory Center for Research on Health Promotion in Older
Minorities
1998 - Dean's Clinical Research Committee
1995 Academic Computing Advisory Committee
1996 Disease Management Committee
2003 - Alzheimer's Disease Research Center
2003 - Mentored Clinical Research Scholars Program
2004 - 2008 Study Director, Third Year Dual Degree Program
2007 - Promotions and Tenure Committee
Durham Veterans Affairs Activities:
1987 VA Quality Assurance Committee
1988 VA Medical Records Committee

1996 - Pharmacy and Therapeutics Committee, VAMC, Durham
Research Grants:
10/09 –
10/11
S$98,620
Principal
Investigator
09/10 –
08/13
S$465,500
Investigator
06/10- 05/12
S$922,590
Investigator
10/10-09/12
S$ 394,620
Investigator
08/28/09–
08/27/14
S$5,000,000
Principal
Investigator
11/10/08-
11/09/11
S$737,873
Co-
Investigator
A study of the impact of caring for stroke survivors on family structure and
the mental health of caregivers (Ministry of Community Development, Youth
and Sports)
Intervention programmes to minimize caregiving burden and allow stroke survivors
to remain longer in the community.
Optimizing local management of global pandemics – a modeling approach
This study has three main components: 1) statistical analysis of outbreak and
epidemic data, 2) modeling epidemic spread and effectiveness of different
interventions, and 3) economic and policy analysis on cost-benefit and optimal mix
of strategies
The health, social and financial effects of care-giving among primary and
secondary domestic caregivers of elderly stroke patients in the first post
stroke year: a prospective study
The primary aim of the study is to prospectively assess the health, social and
financial effects of care on a cohort of stroke patient-caregiver dyads from stroke
onset to one year post stroke.
Cardiac Arrest and Resuscitation Epidemiology in Singapore: Comparison of
Outcomes with Implementation of Systems Status Plan (CARE IV)
This is an observational prospective study looking at response times and survival
outcomes for emergency medical services (EMS) before and after implementation
of a Systems Status Plan (SSP).
Establishing a practical and theoretical foundation for comprehensive and
integrated community, policy and academic efforts to improve dementia care
in Singapore (National Medical Research Council and Agency for Science,
Technology and Research)
To establish a laboratory in Singapore for health systems modeling which provides
a basis for systematic scenario planning to offer innovative approach to the
challenges of rapid growth of Singapore's aged population and concomitant rise in
dementia prevalence.
Health Technology Assessment Capacity Building in India (Temasek
Foundation)
To enhance the management of health care and hospital services in North India
through building capability of health care and hospital administrators, managers and
clinicians in rational, evidence-based decision-making in health care policy and
practice. This will be achieved through creation of models both in the government
and private sector.

10/01/07-
09/30/12
$1,500,000
Network
Director
10/01/07-
02/28/10
$224,023
Investigator
09/30/07-
07/31/12
$499,447
Principal
Investigator
09/25/07-
09/24/09
$320,513
09/01/07-
08/31/12
$58,000
Investigator
03/19/08-
09/30/09
$390,528
Principal
Investigator
Evidence-based Practice Centers III (Agency for Health Care Policy and
Research)
To conduct comparative-effectiveness reviews (CER on medications, devices, and
other interventions. (funds awarded per task order, effort is assigned at that time)
DEcIDE Health Outcomes of Carotid Artery Disease (Agency for Health Care
Policy and Research #290200500321-TO2-WA1-20EHC10)
The Duke DEcIDE Network Center proposes to collaborate with the Centers for
Medicare and Medicaid Services (CMS) Coverage and Analysis Group to develop a
comprehensive approach to inform key clinical and policy questions related to CAS
(including research needs), that takes maximal advantage of available data, and
links to the existing mechanisms for technical assessment available to CMS.
Expanding Quality Care for Glaucoma through a Provider-Patent Partnership
Our proposed study is a community-based, randomized, controlled trial that
evaluates the stability and effectiveness of a technology-based (tablet computer)
intervention within the context of a novel partnership between optometrist and
patients with glaucoma to improve the process quality of care and ultimately
outcomes of care.
Collaborative Research of Clinical Effectiveness and Long Term Outcomes of
Stents in Coronary Interventions (DEcIDE Network)
[Agency for Health Care Policy and Research #HHSA90200500321, TO #4]
Two DEcIDE centers will undertake a series of varied and inter-related research
work assignments to understand the benefits and harms of stents in coronary artery
disease.
Methods and Dissemination (Agency for Health Care Policy and Research #290-
2007-10066-I T.O. 1)
The support the production of quality Evidence Reports that can be used and
understood by appropriate stakeholders, the EPC shall commit adequate time and
resources to advancing the methodology of systematic review. The EPC director
shall be involved in regular schedule calls with AHRQ to identify, discuss, and work
towards developing a standard approach to key methodological issues in
systematic review. The degree of involvement shall be determined by AHRQ
needs, program priorities, and EPC technical resources. What approval from
AHRQ, the EPC shall also support dissemination of research finding from AHRQ
supported EOC report through oral or written presentation to relevant stakeholders
and the public.
Renal Physicians Association – 10-site Implementation of the Advance CKD
Guideline
To support the production of a comprehensive evidence report, clinical practice
guideline and clinical performance measures, and the Advanced CKD Patent
Management Toolkit.

09/30/05-
09/30/09
$974,026
($ awarded
per work
order)
9/27/06-
01/31/09
$239,245
Network
Director
12/01/07-
11/30/08
$160,000
Co-
Investigator
02/01/06-
06/30/06
$105,000 PI
11/01/05-
12/31/06
$20,000
Investigator
11/01/05-
10/16/06
$110,000 PI
10/1/05-
9/30/07
(up to
$974,026)
($ awarded
per TO)
Director
09/30/05-
06/30/06
$162,000
Investigator
DEcIDE Broad Based Support (DEcIDE Network)
[Agency for Health Care Policy and Research #HHSA290200500321, TO #2]
To develop new scientific evidence and methods to address knowledge gaps
relevant to improving the health care delivered through the Medicare, Medicaid, and
the State Children’s Health Insurance programs.
A Prospective Multicenter Trial to Assess the Effects of Medication Therapy
Management on Improving Drug Safety and Effectiveness in Medicare
(DEcIDE Network)
[Agency for Health Care Policy and Research #HHSA290200500321, TO #3]
To improve medication safety in Medicare beneficiaries. Focus on at least three
elements, (a) education and counseling patients to improve understanding their
medications, (b) improving adherence to medications, (c) detecting adverse events
and patterns of prescription over use and under use.
Fostering Immediate Practice-Altering Clinical Trials (KAI Research, Inc.)
Develop a mathematical model that can provide an estimate of the potential impact
of any given clinical trial in neurology or neurosurgery.
Evaluation of Non-invasive Tests of Coronary Anatomy (EPC II/CPTA)
[Agency for Health Care Policy and Research - Contract #: 290-02-0025, Sub#15-
P3039939]
General Registry Follow-up (EPC II/CPTA)
[Agency for Health Care Policy and Research - Contract #: 290-02-0025-
P3039939]
To produce a reference for the design and use of successful registries both for
registries that may be required by CMS and registries set up for other purposes in
both the public and private sectors.
Testing for Cytochrome P450 Polymorphisms in Adults with non-Psychotic
Depression (Evidence-based Practice Centers II)
[Agency for Health Care Policy and Research #290-02-0025, Task Order #10]
Cost reimbursement task order contract - DEcIDE Network (Agency for Health
Care Policy and Research #HHSA290200500321)
Provide a variety of services and products to support the development of new scientific
knowledge through research on the outcomes of the healthcare items and services.
Develop scientific evidence and new analytic tools to assist healthcare providers,
patients, and policy makers with making informed decisions about the comparative
effectiveness, appropriateness, safety, and outcomes of healthcare items and
services, particularly prescription and medications and medical devices.
Treatment of In-stent Restenosis (DEcIDE Network)
[Agency for Health Care Policy and Research #HHSA290200500321, TO #1]
Survey the rates of repeat revascularization in patients with bare metal stents and drug
eluting stents over a multi-year follow up period; survey the utilization of treatment
used for repeat revascularization, and outcomes associated with these treatments.

08/15/05-
02/28/06
$65,000 PI
08/01/05-
07/31/07
$698,052
($ awarded
per work
order)
06/15/05-
09/30/07
$187,000 PI
03/01/05-
08/31/05
$31,000 PI
02/01/05-
08/31/05
$44,000
Investigator
01/05 –
01/08
R812,000
11/01/04-
05/31/07
$250,000
Principal
Investigator
10/01/04-
09/30/06
(138,212)
Principal
Investigator
Evaluation of QOL Measures in Macular Degeneration (EPC II/CPTA)
[Agency for Health Care Policy and Research - Contract #: 290-02-0025, Sub #13-
P3039939]
Comparative Effectiveness Reviews for MMA Section 1013 (EPC II)
[Agency for Health Care Policy and Research #290-02-0025]
To conduct comparative-effectiveness reviews (CER) on medications, devices, and
other interventions.
Comparative Long-term Benefits and Harms of ACE-inhibitors versus ARBs for
Treating Hypertension (Evidence-based Practice Centers II)
[Agency for Health Care Policy and Research #290-02-0025, To #7/Work #1]
Evaluation of Point of Care Testing of HgA1c (EPC II/CPTA)
[Agency for Health Care Policy and Research - Contract #: 290-02-0025 Sub #12-
P3039939
Subcontract for Development of a Monograph on the Development and
Application of Registries (EPC II/CPTA)
[Agency for Health Care Policy and Research - Contract #: 290-02-0025, Sub#11-
P3039939]
A Study of Practice Patterns in Unstable Angina in Secondary and Tertiary
Health Care Setup in and Around Nagpur (Central India)
[Pfizer, Dr. Prashant Jagtap, MD, DM, FACC, PI]
Evaluate and improve the concordance between the management of unstable
angina in secondary and tertiary health care centers and the ACC/AHA
guideline for unstable angina.
Judging The Value Of New Therapies For The Care Of Patients With Chronic
Kidney Disease: Developing and Applying A Comprehensive Model-based
Approach [Abbott Laboratories]
Develop an advanced chronic kidney disease pharmacoeconomic model as a publicly
available repository of best epidemiological evidence, which can be used to evaluate
the development and outcomes of advance chronic kidney disease.
Development of a Public Use Simulation Model of Stroke in Support of Informed
State Policy-making
[Centers for Disease Control and Prevention - Contract #: MM-0919-05/05]
Revise the DSPM to incorporate state level information and to generate state-level
estimates of the burden of disease and the impact of new public health initiatives.
Though this can be applied to a wide variety of programs and regions, we will initially
focus on improvement of hypertension control in the state of Mississippi. This project
will be done in collaboration with the Centers for Disease Control, Cardiovascular
Health Branch, the Mississippi Health Policy Center, and Dr. George Howard, a
leading stroke epidemiologist at University of Alabama, Birmingham.

07/04/04-
07/31/06
(285,000)
Investigator
07/01/04-
09/30/05
$58,000 PI
04/01/04-
03/15/05
($19, 481)
Principal
Investigator
02/20/04-
01/31/10
($238,000)
Investigator
02/20/04-
01/31/09
($2,191,761)
Investigator
10/01/03-
09/30/07
($1,874,833)
Investigator
09/30/03-
09/29/07
($1,038,960)
($ awarded
per TO)
Principal
Investigator
09/30/03-
08/31/07
($1,907,894)
Investigator
A proposal to pilot test the advanced chronic kidney disease practice
improvement toolbox
[Renal Physicians Association - PI: Patwardhan]
Understand (a) existing practice patterns for patients with advanced CKD across the
US by specialty, and (b) the socio-economic and heath care environment in which
ACKD patients are managed
Devices (EPC II/CPTA)
[Agency for Health Care Policy and Research - Contract #: 290-02-0025, Sub #5-
P3039939]
Developing a Methodology for Establishing a Statement of Work for a Policy
Relevant Technical Analysis
[Agency for Health Care Policy and Research - Contract #: 290-02-0025]
Develop a draft methodology for establishing an optimal SOW for a policy-relevant
technical analysis.
Hypertension Improvement Project (HIP) (National Institutes of Health - Contract # 5
R01-HL-075373-05)
A randomized, controlled trial that will test the separate and combined effects on BP
control of a continuous quality improvement (CQI) intervention for physicians and a
behavioral intervention for patients.
Hypertension Improvement Project (HIP)
[National Institutes of Health - Contract # (PI): 1 R01-HL-075373 (Svetkey)]
A randomized, controlled trial that will test the separate and combined effects on BP
control of a continuous quality improvement (CQI) intervention for physicians and a
behavioral intervention for patients.
Pharmacogenetics, Biomarkers, and Antithrombotic Therapy
[IH/National Heart, Lung, and Blood Institute (NHLBI) - Contract # (PI): 1 R01-HL-
074724 (Gage)]
Improve the safety and the effectiveness of anticoagulant therapy.
Evidence-based Practice Center (EPC) Technical Support of the Center for
Practice and Technology Assessment (CPTA) Technology Assessment Program
[Agency for Health Care Policy and Research - Contract #: 290-02-0025]
Provide technical support for the Centers for Medicare and Medicaid Services (CMS)
Technology Assessment Program (TAP). Includes various topics covering devices,
procedures and other practices.
Improving the Quality of Diabetes Eye Care
[National Institutes of Health, PI: Paul Lee]
Evaluate new strategies for improving diabetic eye care among community-based
providers (ophthalmologists and optometrists).

03/01/03-
05/30/05
($134,307)
Investigator
01/02/03-
02/14/04
($226,306)
Principal
Investigator
12/01/02-
12/01/03
($99,915)
Investigator
09/01/02-
09/29/03
($64,910)
Principal
Investigator
6/17/02-
09/29/07
($ awarded
per TO)
Co-Director
04/01/02-
12/31/09
($13 million)
Principal
Investigator
01/01/02-
12/01/02
($550,512)
Investigator
01/01/02-
10/30/02
($49,999)
Principal
Investigator
American Headache Society (AHS) – Primary Care Migraine Partnership (PCMP)
Outcome Measurement Assessment
[American Headache Society; PI: Patwardhan]
Evaluate the impact of the AHS-PCMP headache educational program on physician
beliefs, knowledge, and practice.
Criteria to Determine Disability related to Multiple Sclerosis
[Agency for Health Care Policy and Research - Contract #: 290-02-0025]
Develop an EPC evidence report “Criteria to determine disability related to Multiple
Sclerosis”. The report is requested by the Social Security Administration.
Duke Anticoagulation Satisfaction Survey (DASS) Reliability Study
[AstraZeneca Pharmaceuticals - PI: Samsa]
Assess test-retest reliability of a new instrument measuring satisfaction with
anticoagulation
Improving Intervention Module for Stroke Policy Model (AHRQ-Small Grant)
[Agency for Health Care Policy and Research - Contract #: 1RO3-HS-11746]
Develop an intervention language by which stroke prevention, treatment and
rehabilitation interventions can be easily added to the Stroke Policy Model.
Evidence-based Practice Centers II
[Agency for Health Care Policy and Research #290-02-0025]
Cost reimbursement task order contract
The Home INR Study (THINRS) [VA Cooperative Study #481]
A 28-site, 3000 patient randomized controlled trial of the patient self-testing (PST) of
prothrombin time by international normalized ratio (PT INR) with weekly testing
compared to high quality anticoagulation management (HQACM) provided in an
anticoagulation clinic with conventional monthly testing.
Duke Center to Eliminate Racial Health Disparities. Testing Race Sensitive
Strategies to Improve Patient and Physician Control of Hypertension
[Duke University - PI: Svetkey]
Examine the individual and interactive effects of an intensive dietary education,
lifestyle modification, motivational counseling for patients with stage 1 or 2
hypertension and a training and CQI program for their physicians as strategies to
optimize the adherence of emerging racial minorities and persons living in poverty to a
reduced-sodium DASH diet. The findings from this proposal will offer quantitative
support for a multi-faceted patient/provider approach to enhancing patient adherence
to beneficial life style alterations that reduce BP.
Report on the Epidemiology And Cost of Multiple Sclerosis
[Bristol Myers Squibb]
Estimate the overall burden of MS, in terms of mortality, quality of life and economic
cost; and the likely reduction in the burden that could be achieved by BMS’s new drug.
This estimation can best be made through a cost-effectiveness (CEA) model.

09/30/01-
09/29/06
($1,208,292)
Principal
Investigator
07/02/01-
02/28/02
($149,848)
Principal
Investigator
02/01/01-
05/30/03
($37,800)
Principal
Investigator
01/01/01-
12/31/02
($203,306)
Investigator
12/01/00-
06/30/02
($124,734)
Investigator
10/01/00-
09/30/02
($280,250)
Principal
Investigator
A Randomized Trial of Headache Management Programs
[National Institutes for Health (NIH)/AHRQ - Contract #: 5R01-HS-10893]
Determine whether headache management programs should be promoted as an
effective and cost-effective strategy for managing patients with chronic disabling
headache. K24
The Use of Positron Emission Tomography (PET) and Other Neuroimaging
Techniques in the Diagnosis and Management of Alzheimer’s Disease and
Dementia
[Agency for Healthcare Research and Quality - Contract # (co-PI): 290-97-0014, TO#8
(McCrory)]
Focus on the issue of medical benefit of PET scanning, in addition to a standard
evaluation including a clinical examination and structural neuroimaging, for individuals
who may have Alzheimer’s disease (AD) in comparison with other evaluation
strategies that are currently covered by Medicare. The evidence was linked through
the use of a Markov model which provides projections of a variety of important clinical
outcomes. The report was presented to the Medicare Coverage Advisory Committee
to aid in their deliberations about coverage.
Canadian Stroke Policy Model
[Canadian Stoke Network - Co PI: Nichol]
Develop a Canadian version of the Stroke Policy Model.
Modeling the Effectiveness and Cost-effectiveness of an HPV Vaccine
[Merck - PI: Myers]
Develop and validate a general model for evaluating the cost-effectiveness of an HPV
vaccine and to make the general model available to the public on the Worldwide Web.
Development of a New Anticoagulation Instrument, Phase II
[AstraZeneca Pharmaceuticals - PI: Samsa]
Validate an instrument, the Duke Anticoagulation Satisfaction Scale (DASS) to assess
the burden of treatment in a clinical trial of a new anticoagulation agent versus
warfarin.
Development of Clinical Practice Guidelines for Improving the Quality of Care of
Veterans with Multiple Sclerosis
[Paralyzed Veterans of America]
Provide methodological expertise and conduct systematic reviews and synthesis of the
scientific literature to develop Clinical Practice Guidelines for improving quality of care
of patients with multiple sclerosis. At present there are evidence reports and
guidelines being developed on several sub-topics of multiple sclerosis; spasticity,
immunizations, disease-altering therapies, and pregnancy.

09/01/00-
02/28/02
($249,864)
Investigator
08/01/00-
06/30/01
($50,000)
Principal
Investigator
07/01/00-
09/30/02
($351,711)
Principal
Investigator
12/01/99-
08/30/02
($141,661)
Investigator
10/01/99-
09/30/00
($25,000)
Principal
Investigator
10/01/99-
07/31/00
($57,510)
Principal
Investigator
09/01/99-
09/30/99
($10,486)
Principal
Investigator
Management of Post-Term Pregnancy
[Agency for Healthcare and Quality Research - Contract # 290-97-0014, TO#6 (PI -
Myers)]
Address four key issues on management of post-term pregnancy. 1) The available
evidence on effectiveness of fetal measures in antenatal surveillance, 2) The relative
effectiveness of planned induction vs expectant management, 3) The relative
effectiveness of the currently available induction agents, and 4) Effectiveness by race,
ethnicity, or income level.
Technical Assistance to the Moscow Medical Academy
[Agency for Healthcare Research and Quality - Contract #: 290-97-0014 (TO#5)]
Provide technical assistance to the newly-established Moscow Medical Academy
Evidence-based Center (MMA Center). This will include on-site training of health
professionals in the MMA Center. Technical assistance will relate to guidance on
establishing a Russian expert panel to assist the Center in undertaking systematic
reviews, reviewing for accuracy, translations performed by the center staff, guidance
on conducting external peer review in Russia by Russian professional colleagues, of
draft MMA Center reports or guidelines.
Clinical Practice Guidelines on Appropriate Patient Preparation for Renal
Replacement Therapy
[Renal Physicians Association]
Develop an evidence report that provides evidence of best clinical practices for
management of the many health issues related to preparation for renal replacement
therapy.
The Effectiveness of Involuntary Outpatient Commitment (NIMH)
[NIMH - PI: Swartz]
Address the priorities outlined in the NIMH National Advisory Mental Health Council's
Clinical Treatment and Services Workgroup Report, "Bridging Science and Service".
Use of the EPC Uterine Fibroids Model to Explore Clinical Treatment Decisions
[Agency for Health Care Policy and Research - Contract #: 290-97-0014, TO#4]
Develop an evidence report on management of uterine fibroids for use in development
of clinical practice guidelines by the American College of Obstetricians &
Gynecologists
Systematic Review of Controlled Trials of Behavioral and Physical Treatments
for Tension-Type and Cervicogenic Headache
[Foundation for Chiropractic Research and Education]
Economic Impact of Stroke in North Carolina, South Carolina and Georgia
[NC Dept. of Health and Human Services]

08/16/99 -
06/30/00
($36,332)
Principal
Investigator
07/01/99-
06/30/04
($190,031)
Principal
Investigator
06/01/99-
12/30/99
($50,000)
Principal
Investigator
04/01/99-
03/31/00
($227,886)
Principal
Investigator
10/01/98-
09/30/99
($198,213)
Investigator
05/01/98-
05/01/00
(162,000)
Investigator
10/01/97-
01/15/98
($112,410)
Principal
Investigator
Develop a New Anticoagulation Instrument
[Astra Pharmaceuticals]
Develop an instrument to evaluate the impact of anticoagulation: limitations, risks and
management. This instrument will ultimately be used to assess the burden of
treatment in clinical trials of alternative models of anticoagulation.
RPA Implementation of Clinical Practice Guidelines for Advanced CKD Patients
[Renal Physicians Association]
Develop tools for improving care of patients with advanced chronic kidney disease
(GFR < 30, not yet on renal replacement).
Development of a User-Friendly Model of the Health and Economic Impact of
Stroke
[Knoll Pharmaceuticals]
Create an user-friendly web-based version of the Stroke Policy Model that would
benefit private physician, clinicians, and managers in medical center, managed care
organizations, the insurance industry, researches, as well as pharmaceutical
companies.
Evidence Report: Treatment of Pulmonary Disease Following Spinal Cord Injury
[Agency for Health Care Policy and Research - Contract # (Co PI): 290-97-0014, TO#3
(McCrory)]
Develop an initial draft of a conceptual model to assist thinking in determining when
and how it is appropriate to apply evidence from non-randomized designs within
evidence reports and other information synthesis applications; illustrate the use of this
conceptual model as applied to a case study from an EPC evidence report in spinal
cord injury (SCI); and produce a white paper and/or journal article describing the
results of our research.
Management of Acute Exacerbations of Chronic Obstructive Pulmonary Disease
(COPD)
[Agency for Health Care Policy and Research - Contract # (PI): 290-97-0014, TO#2
(McCrory)]
Develop an evidence report on the management of acute exacerbations of chronic
obstructive pulmonary disease.
Improving Quality of Care Through a Multidisciplinary Headache Management
Service
[Aetna US Healthcare]
Identify, pilot and ultimately test the development of a headache management service
in a randomized trial.
Acute Stroke Treatment Model for Lubeluzole: FASTModeL
[Janssen Pharmaceutical]
Develop an “user-friendly” version of the lubeluzole cost-effectiveness model that
illustrates the health and impact of lubeluzole for specific types of patients, as well as
populations.

07/01/97-
12/31/98
($55,575)
Investigator
05/1/97-
01/31/02
($341,600)
Principal
Investigator
1997-1998
($38,218)
Investigator
1996-2001
($4,039,315)
Consultant
1996-2000
($116,656)
Investigator
1996-1999
($186,844)
Investigator
04/01/96-
04/30/97
($66,496)
Principal
Investigator
12/01/95-
06/30/02
($1,010,687)
Principal
Investigator
1994-1998
($167,292)
Principal
Investigator
1994-1998
($843,463)
Principal
Investigator
The Economic Analysis of the Trasylol Clinical Trials
[Bayer Corporation]
Perform an independent and comprehensive analysis of the cost-effectiveness of
Trasylol.
Duke Health Outcomes Policy Working Group
[Pfizer Pharmaceuticals]
Support research in health outcomes through industry/academic collaborations.
Determining the Minimal Clinically Significant Difference in the Health Utility
Index
[Janssen Research Foundation]
CPRU: Improving Cancer Risk Communication
[National Institutes of Health]
Study ways of improving communication of information about cancer risk.
Effects of Public Subsidies on Use of Long Term Care
[National Institute on Aging]
Interactive, Guideline-Based Decision Support on the Web
[Agency for Health Care Policy and Research]
Evaluation of Health and Economic Impact of Acute Stroke Treatment
[G.D. Searle and Company]
A Randomized Trial of Anticoagulation Services for Stroke Prevention
[DuPont Merck]
Perform a randomized trial to assess the effectiveness and cost-effectiveness of ACSs
in improving anticoagulation management for patients with AF.
Evidence Report: Evaluation of Abnormal Cervical Cytology
[Agency for Health Care Policy and Research]
Evidence Report: Chronic Pain -- Headache
[Agency for Health Care Policy and Research]

1994-1998
($1,511,900)
Principal
Investigator
1994-1996
($1,104,699)
Principal
Investigator
1994 (1year)
($9,750)
Investigator
1992-1995
($599,806)
Investigator
1992-1994
($45,390)
Investigator
10/01/91-
09/30/92
($70,000)
Principal
Investigator
09/30/91-
09/30/00
($689,314)
Principal
Investigator
09/30/91-
09/29/96
($5,627,836)
Principal
Investigator
1991-1994
($869,798)
Investigator
01/01/91-
06/30/93
($75,000)
Principal
Investigator
Clinical Management and Outcomes of Veterans with Stroke at VAMCs
[Department of Veterans Affairs]
Development and Periodic Updating of Clinical Practice Guidelines, Medical
Review Criteria, Standards of Quality and Performance Measures on Chronic
Pain: Headache
[Agency of Health Care Policy and Research]
Radioisotope Dilution Assay (RIDA) for B12, Methylmalonic Acid Excretion and
Clinical Criteria in the Diagnosis of B12 Deficiency
[Department of Veterans Affairs]
Clinical Practice Guidelines for Unstable Angina
[Agency for Health Care Policy and Research]
Developing Efficient Strategies for Managing Sinusitis: A Randomized Trial
[Department of Veterans Affairs/Health Services Research/Small Project Program]
Health and Economics Outcomes Program
[Pfizer Pharmaceuticals]
Supplement to Secondary and Tertiary Prevention of Stroke PORT
[Agency for Health Care Policy and Research]
Secondary and Tertiary Stroke Prevention PORT
[Agency of Health Care Policy and Research]
Care of Critically Ill Hospitalized Adults
[Robert Wood Johnson Foundation]
Improving Methods for Developing Appropriateness Criteria
[Academic Medical Centers Consortium]

07/01/90-
06/30/93
($28,000)
Principal
Investigator
01/01/90-
12/31/92
($41,000)
Principal
Investigator
09/01/89-
02/01/90
($33,333)
Principal
Investigator
1988-1989
($10,000)
Investigator
1988-1989
($50,000)
Core Leader
1987-1988
($9,890)
Consultant
1986-1989
($290,304)
Principal
Investigator
Initiative to Improve the Efficacy of Medical Care
[Academic Medical Centers Consortium]
Improving Consensus in Clinical Guideline Development
[Academic Medical Centers Consortium]
Cerebral Vascular Disease: Optimizing Patient Care
[National Center for Health Services Research]
A Rapid Test of Language Function: The QAT
[A.W. Mellon Foundation]
Predicting Outcomes for Ventilated Patients in the Medical Intensive Care Unit
[Veterans Administration Cooperative Studies]
Predicting Outcome of Invasive Studies in Patients with Syncope
[A.W. Mellon Foundation]
Influence of Hyperglycemia on Outcome of Cerebral Infarction
[National Institute for Neurologic and Communicative Diseases and Stroke]
Training and Career Grants:
1992-1993
($1,865,757)
Training
Fellowship
1991-1993
Training
Fellowship
Geriatric Research and Training Centers
[National Institutes on Aging]
A Model of Patient Preferences in Serious Illness
[Agency for Health Care Policy and Research]

1990-1994
($132,256)
Research
Fellowship
1984
($4,000)
Training
Fellowship
1984
($2,000)
Training
Fellowship
Personal Information:
Preferred
familiar
name:
Business
Contact
Information:
Cerebrovascular Research Training Program
[National Institutes of Health]
Clinical Decision Analysis
[A.W. Mellon Foundation]
Ciba-Corning Medical
DAVID
Duke-NUS Graduate Medical School Singapore
8 College Road Singapore 169857
Phone: (65) 6516 2584; Fax: (65) 6534 8632;
Email: david.matchar@duke-nus.edu.sg