Chairman's Note - Penn Medicine - University of Pennsylvania

EXCELLENCE IN PATIENT CARE, EDUCATION AND RESEARCH SINCE 1870 

Data Report – TransOral 

Robotic Surgery (TORS) 

– Continuing to Open New 

Frontiers and New Standards of 

Care in Head and Neck Surgery 

Penn Medicine’s Department of Otorhinolaryngology – Head and Neck 

Surgery is continuing to break new ground in the field of robotic surgery. 

Scientific outcomes data has just been published providing evidence that 

TransOral Robotic Surgery (TORS) is generating results so successful that it 

is literally outpacing, and on the way to becoming, the new standard of 

care in the field. 

Bert W. O’Malley, Jr., MD, Gabriel Tucker Professor and Chairman, and 

Gregory S. Weinstein, MD, Professor and Vice Chairman of Penn 

Medicine’s Department of Otorhinolaryngology – Head and Neck Surgery 

are pioneers in the field of robotic surgery. In 2004, they founded the 

world’s first TransOral Robotic Surgery (TORS) program at Penn, where 

they developed and researched the TORS approach for a variety of robotic 

surgical approaches for both malignant and benign tumors of the mouth, 

larynx, tonsil, tongue and other parts of the throat. TORS was approved by 

the U.S. Food and Drug Administration in the latter part of 2009 when the 

daVinci Surgical System (Intuitive Surgical, Inc., Sunnyvale, California) was 

cleared for transoral otolaryngologic surgical procedures to treat benign 

tumors and select malignant tumors in adults. 

Designed to avoid incisions for primary site resection, TORS is performed 

through the patient’s mouth and provides unprecedented access to the 

small and often difficult-to-reach areas of the mouth and throat. 

Since 2005, approximately 400 Penn Medicine patients have participated in 

the world’s first clinical trials of TORS. These research trials represent the 

largest and most comprehensive studies of the technology on record. 

Today, outcomes studies have been completed illustrating how TransOral 

Robotic Surgery (TORS) has dramatically improved the way head and neck 

cancer patients are treated, completely removing tumors while preserving 

speech, swallowing and other key quality-of-life issues. These successful 

Continued on pg. 3 

WWW.uPhS.uPenn.edu/PennOrl 

vOlume 5 fall/Winter 2010 

Chairman’s Note 

It has been another great year 

for our Department on all 

fronts. I must start out by saying 

that our clinical growth and 

success is reaching amazing 

new highs. Our collective faculty 

are achieving an average of 

58% above the 65% percentile 

in RVUs per clinical FTE. You 

may think that we never go Bert W. O’Malley Jr., MD 

home or travel. On the contrary, 

we are working in a highly efficient and organized 

manner that allows us to achieve these stratospheric levels 

of clinical activity while still focusing on family and 

friends in addition to succeeding in our educational and 

research goals. How do we do this? Well, ask us! 

From the research standpoint, our senior faculty have 

been successful in capturing funding from various 

sources including the NIH, DOD, foundations, and from 

corporate-sponsored clinical trials. While we are still 

struggling and pushing to grow our NIH funding, we 

were fortunate to have received approximately $4 million 

in total costs last year from our DOD grants and 

investigator-initiated clinical trials contracts. 

Concordant with our research growth is our publication 

record and impact. As we look to the future, we will be 

developing a research strategic plan to carry us through 

the next five years which will include a significant hire in 

the area of cancer research. 

As I have previously stated, the faculty and staff in our 

Department have rallied once again to take our program 

to new heights of patient care, scientific discovery, 

education, and clinical innovation. 

Bert W. O’Malley, Jr., MD 

Gabriel Tucker Professor and Chairman

OtOrhinOlaryngOlOgy - head and neck Surgery at the univerSity Of PennSylvania 

The Evolution of Minimally-Invasive 

Skull Base Surgery at Penn Medicine 

The treatment of skull base tumors continues 

to evolve, and Penn Medicine physicians 

and researchers are at the forefront of these 

revolutionary new treatment methods. 

Skull base tumors including chondrosarcoma, 

esthesioneuroblastoma, squamous 

cell carcinoma, adenoid cystic carcinoma, 

melanoma, meningioma, craniopharyngioma, 

and chordoma are some of the 

most challenging, complex and technically 

demanding tumors to treat. 

Penn Medicine’s multidisciplinary team of 

physicians from the departments of 

Otorhinolaryngology – Head and Neck 

Surgery, Neurosurgery, Radiation Oncology, 

Medical Oncology and Neuroradiology are 

bringing new hope to patients with both 

malignant and benign tumors of the skull 

base, sinuses and brain. These worldrenowned 

physicians are pioneers in the 

development of minimally-invasive innovative 

surgical procedures and state-of-the-art 

imaging. Many tumors previously 

inaccessible can now be successfully treated. 

At Penn Medicine’s Center for Cranial Base 

Surgery, important collaborations continue 

to grow as well. The department of 


Surgery has six dedicated endoscopic 

skull base surgeons who work alongside a 

team of three highly skilled endoscopic 

skull base neurosurgeons from Penn’s 

department of Neurosurgery. These national 

and international leaders are leading the 

charge in the new millennium of skull base 

surgery. In addition, our team of surgeons 

have partnered with our radiation 

oncologists on a prospective evaluation and 

study of the role of Proton Beam Radiation 

Therapy for skull base benign and 

malignant tumors. We are excited about 

the potential role of Proton Therapy and 

how it will synergize with our minimallyinvasive 

surgical techniques. 

From the initial skull base surgery team 

meetings where each patient’s case is discussed 

and an individualized treatment plan 

2 WWW.uPhS.uPenn.edu/PennOrl 

developed, to the actual surgical procedure, 

an intuitive, synergistic cohesion has developed 

that greatly benefits the patients. 

Penn possesses a powerful arsenal of treatment 

modalities to combat skull base 

tumors. One of the things that has been 

lacking in minimally-invasive endoscopic 

surgery has been depth perception. An 

exciting new technology, 3D endoscopy, is 

taking minimally-invasive surgery to the 

next level, so that it is quicker, safer, and 

more efficient. Penn is only one of two or 

three centers in the entire country to use 

this technology. 

The surgery is performed transnasally. A 

camera creates a 3D view of the surgery, 

greatly enhancing depth perception and 

enabling the surgeon to see with stereoscopic 

vision where it is critical to do so, 

and improving the ability to do very fine 

work. The surgeons wear special goggles as 

if they were watching a 3D movie. 

Penn continues in its pioneering work in 

minimally-invasive robotic surgery and is 

working to develop surgical approaches for 

the treatment of skull base tumors. 

Dr. Bert W. O’Malley, Jr., Dr. Gregory S. 

Weinstein and Dr. Jason G. Newman of the 

Department of Otorhinolaryngology – 

Head and Neck Surgery and Dr. M. Sean 

Grady, Dr. William Welch and Dr. John Y. K 

Lee of the Department of Neurosurgery are 

working with industry to improve on technology 

and create new techniques. From 

the team that revolutionized the treatment 

of throat cancers with TransOral Robotic 

Surgery (TORS), continued groundbreaking 

procedures are being devised, 

including the first robotic transoral 

odontoid surgeries in the world. 

“Penn Medicine is changing the face of 

minimally-invasive skull base surgery in the 

world today. We continue to make strides 

in developing the latest treatments available 

to provide the best care for our patients,” 

said Dr. Newman. 

Penn International Rhinology 

and Comprehensive Skull 

Base Courses 

The Penn International Rhinology and 

Comprehensive Skull Base Courses were 

held from March 11-14, 2010. This course 

was the 25th anniversary of Penn’s first 

endoscopic sinus surgery course. 

This comprehensive program featured an 

outstanding national and international faculty 

and focused on medical and surgical 

advances in the management of sinonasal 

disease and skull base disorders 

with specific emphasis on the frontal and 

sphenoid sinuses, chronic rhinosinusitis, 

skull base surgery, medical therapy, pediatric 

sinusitis, image guidance and powered 

instrumentation and endoscopic 

management of benign and malignant 

skull base tumors. 

Also present was Course Director Heinz 

Stammberger, MD from Austria, and Penn 

Medicine Course Directors James N. 

Palmer, MD; Bert W. O’Malley, Jr., MD; 

David W. Kennedy, MD; M. Sean Grady, 

MD; Noam A. Cohen, MD, PhD and 

Alexander G. Chiu, MD. 

Courses included live skull base surgery 

performed by Dr. Palmer, Dr. John Y.K. Lee, 

and Dr. Kennedy as well as a demonstrated 

dissection and didactic lectures. Special 

highlights included a skull base distinguished 

professor dinner. “This was a fantastic 

learning experience bringing together 

skull base surgeons from all over the globe 

to have input and advance skull base surgery 

using minimally invasive techniques,” 

said James N. Palmer, MD, Associate 

Professor of Otorhinolaryngology – Head 

and Neck Surgery and Director of Rhinology 

at Penn Medicine. 

Mark Your Calendars! 

The next Penn International Rhinology 

and Comprehensive Skull Base Course is 

scheduled for March 10-12, 2011. Hope 

to see you there!

Continued from Page 1 

Data Report – TransOral Robotic Surgery (TORS) 

outcomes are outpacing the standard of care 

formerly regarded as the norm in these cases. 

The standard surgical and nonsurgical 

approaches to the management of laryngeal, 

hypopharyngeal and oropharyngeal cancers, 

while in many ways successful, have significant 

limitations. Originally the combination of surgery, 

radiation therapy and chemotherapy was 

the standard of care. This conventional surgery 

may require an almost ear-to-ear incision 

across the throat, or splitting the jaw resulting 

in speech and swallowing deficits for patients. 

1) Paper Accepted in Archives of 

Otolaryngology, 2010: 

This paper reported the relapse rate and 

the survival figures for the entire group 

with a mean follow-up duration of more 

than two years. This paper reported that 

the chance of living and being cured of a 

cancer in the oropharynx that can be 

removed by TORS is excellent (90%). It 

also demonstrates that the chance of the 

cancer coming back is equal if not greater 

in the chest than in the neck suggesting 

that the treatment given to the neck via 

TORS with or without adjuvant radiation 

+/- chemotherapy may be more effective 

than historic results. 

2) Paper Accepted in Laryngoscope, 2010: 

This paper presented a key benefit of 

TORS as providing pathology information 

from the surgical specimens that allow 

the Head and Neck team to better stratify 

and justify patients for adjuvant 

chemotherapy and radiotherapy. In 

contrast to the situation where TORS 

and neck dissections are not performed, 

all patients with lymph node metastases 

would receive chemotherapy. Our data 

showed that up to 70% of patients 

undergoing TORS were not recommended 

for chemotherapy based on negative 

primary site margins and limited neck 

disease. The use of surgery, TORS, and 

pathology information allows for tailored 

therapy and recommendations for 

adjuvant radiation and/or chemotherapy. 


In contrast, TORS outcomes and the patient’s 

quality of life are markedly improved when 

compared to the standard results. Benefits to 

patients that undergo TORS can include no 

dependence on G-tubes for nutrition, shorter 

hospitalization, a quicker return to normal 

activity, fewer complications compared to 

traditional open surgery, less scarring than 

traditional open surgery, less risk of blood 

transfusion, and no routine use of 

tracheostomy during surgery compared 

to routine use for open surgery. 

3) Paper Accepted in Head and Neck, 2010: 

It is now recognized that cancers in the 

oropharynx (tonsil and base of tongue) can 

either be related to traditional exposure to 

tobacco products or to the infection of certain 

high risk strains of the human 

papillomavirus that can itself cause cancers. 

The two are not mutually exclusive but it is 

now understood that oropharynx cancers 

associated with HPV have a better prognosis 

regardless of how they are treated. That is, 

these cancers are less likely to return 

whether they are treated surgically or with 

radiation therapy. In contrast, the HPV 

negative oropharynx cancers do not do as 

well. This study investigated the results 

when the cancers were tested for the presence 

of certain high risk strains of the 

human papillomavirus. The results are limited 

by the fact that only 50 patients were 

studied but are potentially very provocative. 

The study demonstrated that the HPV positive 

tumors did well as would be expected. 

However, the HPV negative tumors appear 

to be doing better than what would historically 

be expected. This suggests that HPV 

negative tumors MAY be better suited when 

treated with upfront surgery such as TORS 

which allows for surgery in this area without 

significantly increasing the risk of swallowing 

complications. 

4) Paper Accepted in Journal of Robotic 

Surgery, 2010: 

This review paper helps to summarize how 

the use of TORS is defining a new treatment 

approach with what appears to be 

more benefits than risks and may be a way 

“These successful outcomes and the new supporting 

data reflect the exciting fact that TORS 

is on its way to becoming the new standard of 

care in the treatment of head and neck cancer 

patients,” said Dr. O’Malley. 

The journal articles listed below submitted by 

the Department of Otorhinolaryngology – 

Head and Neck Surgery at Penn Medicine further 

illustrate these exciting new outcomes due 

to the TORS procedure. Papers listed include 

those accepted and under review in a variety 

of medical journals within the discipline. 

in which to further reduce the risk of late 

swallowing complications compared to the 

use of chemoradiation for all locally 

advanced oropharynx cancers. 

5) Paper Accepted in International Journal of 

Head and Neck Surgery, 2010: 

This review paper summarizes the current 

indications for the use of TORS for various 

benign and malignant tumors of the head 

and neck. This reflects the Penn experience 

and the experience of other institutions that 

are also beginning to publish their results, 

results which appear to be consistent with 

the results seen at Penn to date. This helps to 

further validate that this approach is potentially 

generalizable to other institutions. 

6) Paper Accepted in the Journal of 

Oto-Rhino-Laryngology, ORL, 2010: 

This review paper summarizes the historical 

development of the use of adjuvant radiation 

therapy with or without the use of 

chemotherapy. It also summarizes the 

unique implications that TORS has when 

deciding on what extra treatment should be 

used after TORS given the pathology findings. 

The study also helps to identify important 

questions that are still unanswered and 

where future research efforts can be placed. 

7) Study In Progress, 2010-2011: 

A larger study is underway which is designed 

to confirm preliminary findings that the risk 

of long-term swallowing complications 

necessitating nutrition through a gastrostomy 

feeding tube is 0% with TORS. 

v O l u m e 5 - fa l l/Winter 2010 3


Research Roundup 

Early Sensory Changes in Patients 

with Neurodegenerative Diseases 

Researchers have 

long suspected that 

environmental 

agents, including 

toxins and viruses, 

may be catalysts for 

a number of 

neurodegenerative 

Richard L. Doty, PhD 

diseases, including 

Alzheimer’s disease 

and Parkinson’s disease. Professor Richard 

L. Doty, PhD, of Penn’s Department of 

Otorhinolaryngology –Head and Neck 

Surgery, a renowned expert in the olfactory 

system, is exploring the possibility that 

some cases of neurodegenerative disease 

may be initiated or catalyzed by 

environmental agents that enter the brain 

via the olfactory pathways. Recently he and 

his colleagues have shown that young 

individuals exposed to high levels of 

pollution in Mexico City exhibit olfactory 

dysfunction and evidence, at autopsy, the 

pathology of Alzheimer’s disease in their 

olfactory bulbs. 


In 1968, Dr. Doty received his MA degree 

from California State University, San Jose, in 

conjunction with the National Aeronautics 

and Space Administration (NASA), where 

he studied the vestibular system of humans. 

He obtained his PhD degree in 

Comparative Psychology from Michigan 

State University in 1973, specializing in 

olfaction. He subsequently completed a 

postdoctoral fellowship in Behavioral 

Endocrinology at the University of 

California, Berkeley. Presently he is the 

Director of the University of Pennsylvania’s 

Smell and Taste Center, which he cofounded 

in 1980. He is perhaps best known 

for developing the University of 

Pennsylvania Smell Identification Test 

(UPSIT), the most widely used quantitative 

test of olfactory function in the world. This 

test has been heralded as the “eye chart of 

the nose” and has been translated into over 

a dozen foreign languages. Dr. Doty, who 

has published more than 350 scientific 

articles, chapters, and books on taste and 

smell, was the 2005 recipient of the 

Association for Chemoreception Science’s 

Max Mozell Award for Outstanding 

Achievement in the Chemical Senses, the 

highest honor that can be bestowed by the 

peers of his profession. 

As a result of funding from the Department 

of Defense, Dr. Doty and his team are 

currently examining sensory changes that 

occur in the earliest stages of Parkinson’s 

disease. Extensive behavioral and 

electrophysiological assessment of all the 

major senses is being made before and after 

dopamine therapy. These results are being 

compared to those from SPECT imaging of 

the dopamine transporter within the 

nigrostrial region of the brain, the brain 

region where the motor symptoms of this 

disease arise. His research is important not 

only for better defining the non-motor 

elements of this disease, but for 

understanding their dependence upon 

dopamine dysfunction, their relationship to 

one another, and whether some 

combination of sensory measures may 

ultimately be useful in identifying people at 

risk for the disorder. In the future, such 

detection may allow for early therapeutic 

intervention before irreversible neural 

degeneration has occurred. 

Dr. Doty notes, “Before the development 

of the UPSIT, the influences of a wide 

range of diseases on the ability to smell 

were unknown. As a result of this single 

development, we now know that a number 

of neurological disorders are heralded by 

olfactory dysfunction. A key question is 

whether such dysfunction aids in 

understanding the etiology of such 

disorders, a question that is currently 

being addressed in laboratories 

throughout the world.”

Oren Friedman, MD 

Oren Friedman, MD, Associate Professor of 


Surgery joins Penn Medicine as a member 

of the Facial Plastic and Reconstructive 

Surgery team as Director of Facial 

Plastic Surgery. 

Dr. Friedman received his medical degree 

and completed his internship in General 

Surgery and his residency in 

Otolaryngology – Head and Neck Surgery 

from Thomas Jefferson University. He 

completed his fellowship in Facial Plastic 

and Reconstructive Surgery at Oregon 

Health and Science University. He last held 

the position of Director of Facial Plastic 

and Reconstructive Surgery in the 

Department of Otorhinolaryngology at the 

Mayo Clinic. 

Dr. Friedman is certified by the American 

Board of Facial Plastic and Reconstructive 

Surgery and is a Diplomate of the American 

Board of Otolaryngology. He is also active 

in a variety of professional and scientific 

societies including the American Academy 

of Facial Plastic and Reconstructive Surgery, 

the American Academy of Otolaryngology– 

Head and Neck Surgery, and the American 

Medical Association. Dr. Friedman is a 

reviewer of several journals including The 

American Journal of Rhinology; the Archives 

of Facial Plastic Surgery; Dermatologic 

Surgery; Mayo Clinic Women’s HealthSource 

and Otolaryngology – Head and Neck 

Surgery. 

Dr. Friedman’s clinical practice primarily 

focuses on facial plastic and reconstructive 

surgery. His passions in the field of 

reconstructive facial surgery include 

rehabilitating facial function secondary to 

facial paralysis, reconstructing skin cancer 


FACULTY Spotlight 

The Department of Otorhinolaryngology – 

Head and Neck Surgery Welcomes 

defects, congenital facial deformities 

including cleft lip and microtia (ear 

malformations), and managing patients 

with traumatic facial injuries. He is actively 

involved in humanitarian medical missions 

through a number of different 

organizations, parcticularly in the fields of 

cleft lip and palate, and microtia surgery. 

“Humanitarian trips such as these are 

essential parts of my life. Serving patients 

in places they would otherwise be left 

untreated is the most rewarding thing 

I do,” he said. 

In addition, he specializes in surgical 

cosmetic procedures including facelift, 

browlift, blepharoplasty (eyelids), and 

rhinoplasty. Dr. Friedman’s practice also 

offers cosmetic procedures in the office, 

including Botox®, chemical peels, laser 

skin resurfacing, dermabrasion, and 

injectable fillers (previously referred to as 

collagen injections). 

Dr. Friedman focuses a large part of his 

efforts in cosmetic facial surgery on 

utilizing minimally-invasive surgical 

techniques. This allows patients to get the 

best outcomes possible with the smallest 

amount of downtime. It also helps to avoid 

some of the primary complications 

associated with bigger operations. 

In addition to his interest in facial plastic 

surgery, Dr. Friedman has been extremely 

active in the medical and surgical 

management of patients with chronic 

rhinosinusitis and sleep disorders and hopes 

to continue this work at Penn Medicine. 

Dr. Friedman’s research interests include 

clinical research in the area of functional 

nasal surgery, and outcomes following 

cosmetic and functional facial surgery. 

He is currently involved in an exciting 

project seeking to reduce the need for 

surgical intervention in children born with 

congenital ear deformities by applying a 

non-surgical splint to the ear to recontour 

it. 

“There is a quote that one of my mentors 

shared with me that has become a practice 

philosophy that I live by,” said Dr. 

Friedman. ‘“Be a minimalist in the 

operating room and a maximalist in the 

office.’” “This is the essence of my practice,” 

he continued. “I take pride in taking 

excellent care of my patients before, during, 

and after surgery. I like to take time to 

counsel them, get to know them, and 

establish excellent rapport with them.” 

Dr. Friedman’s position at Penn brings him 

back to the Philadelphia area, which was 

once home to both he and his wife. “This 

position merges the best of all worlds for 

me and my family,” he shares. “I am 

honored to be joining an outstanding 

medical institution with the reputation of 

Penn, a world-renowned department in 

Otorhinolaryngology, and to be able to 

continue in the work that I started at the 

Mayo Clinic closer to home. This is truly 

the opportunity of a lifetime.” 


hiStOry 


cOrner 

Otorhinolaryngology–Head and Neck 

Surgery at the University of Pennsylvania 

The Evolution of a Specialty Continued... 

—A Journey to One United Department 

From its earliest days, the Department of 

Otorhinolaryngology-Head and Neck 

surgery has been shaped by a coterie of 

some of the most respected clinicians, 

researchers, and educators in the world. 

Originally founded in 1870, the 

Department’s current structure was 

established in the year 1924 with the 

appointment of George Fetterolf, MD 

as the first Chairman of the combined 

Department of Otorhinolaryngology. 

Further modifications of departmental 

structure have been made over time by 

multiple Chairmen. The changes made 

were dependent on clinical, technological, 

and research growth within the specialties 

of Otorhinolaryngology, Human 

Communication, and Head and 

Neck Surgery. 

1870-1890 

George Strawbridge, MD, 

Professor and Chairman of the 

Department, then called 

Diseases of the Ear 


The Birth of the Graduate School 

of Medicine of the University of 

Pennsylvania 1918-1965 

The Carnegie Foundation for the 

Advancement of Teaching’s Abraham Flexner 

report of 1910 described the confused 

pattern of medical education in Philadelphia. 

The city’s multiple medical schools and 

general hospitals provided good clinical 

training for residents, but frequently did not 

provide adequate experience in the basic 

aspects of the specialties. A need existed for 

combined specialized scientific and 

laboratory training in conjunction with 

residency—(a Graduate School of 

Medicine). The report recommended a 

broader merger scheme. 

In 1918, an alternative unique institution for 

graduate training in medical specialties 

evolved as the Graduate School of Medicine 

1890-1905 

Burton Alexander Randall, 

MD, PhD, Professor and Chair 

of Diseases of the Ear; from 

1905 to 1925 he was Professor 

and Chair of the 

Department of Otology 

1905-1926 

Charles P. Grayson, MD, 

Professor and Chairman of 

Laryngology and Rhinology 

(GSM) of the University of Pennsylvania. 

This resulted from a merger of the Medico- 

Chirurgical Medical School, founded in 

1867, and the Philadelphia Polyclinic and 

College for Graduates in Medicine. Due to 

interruptions caused by World War I, this 

new department did not begin to offer 

courses until the 1919-1920 academic year. 

The Graduate School of Medicine (GSM) 

was generally regarded as the prime training 

center in the United States for 

otolaryngologists and offered Master’s of 

Science and Doctors of Science degrees in 

Otolaryngology. 

From 1919 to 1953, Otolaryngology was 

represented in the Graduate School by two 

different Departments, Otology and 

Laryngology. From 1919 to 1933, George M. 

Coates, MD served as Head of the 

Department of Otology and George Wood, 

MD was the Head of the Faculty in 

1926-1933 

George Fetterolf, MD, the first 

Chairman of the 

combined Department of 

Otorhinolaryngology 

1934-1940 

George M. Coates, MD, 

Professor and Chairman 

of Otolaryngology

George M. Coates, MD 

Laryngology. Dr. Coates was succeeded by 

Edward H. Campbell, MD, from 1933 to 

1953 and Dr. Wood by Karl Houser, MD. 

In 1953, the two separate Departments 

merged under Chairman Louis E. Silcox, 

MD from 1953 to 1960, followed by Bernard 

J. Ronis, MD from 1960 to 1963, and David 

Meyers, MD from 1964 to 1965. 

In 1964-65 the faculty of the Graduate 

School was officially merged with that of the 

University of Pennsylvania School of 

Medicine as part of the Department of 

Otorhinolaryngology. 

1940-1959 

Harry P. Schenck, MD, 


Otolaryngology 


1959-1972 

Philip Marden, MD, 


Otolaryngology 

The Department of Bronchoscopy 

and Esophagoscopy of the Graduate 

School of the University of 

Pennsylvania – An Important 

Piece of the Puzzle 

In 1919 the world’s first Department of 

Bronchoscopy and Esophagoscopy was 

created as part of the University of 

Pennsylvania Graduate School of Medicine. 

Chevalier Jackson, MD was Chairman. 

Personal courses were sanctioned in 1921, 

including courses in laryngology, 

bronchoscopy and esophagoscopy which 

were led by Dr. Jackson as well as Gabriel 

Tucker, MD and Louis Clerf, MD. In 1930 

Gabriel Tucker, MD succeeded Dr. 

Jackson as Professor and Chairman. In 

1933 Laryngeal Surgery was added. In 

1950 the departments were combined 

and a new department was formed, 

entitled Broncho-Esophagology and 

Laryngeal Surgery. In 1954 Joseph P. 

Adkins, MD succeeded Gabriel 

Tucker, MD as Chairman. In 1968 he 

was succeeded by John A. Tucker, MD 

as the Gabriel Tucker Chairman. 

In 1972 all of the departments of the 

Graduate School were merged under 

the School of Medicine. James B. 

1972-1990 

James D. Snow, Jr., MD, 

Chairman of the Department of 

Otolaryngology and Human 

Communication 

1990-2003 

David W. Kennedy, MD, 

Chairman of the Department of 

Otorhinolaryngology-Head and 

Neck Surgery 

Snow, Jr., MD was appointed Chairman of 

the Department of Otolaryngology and 

Human Communication. 

From the early days under separate 

departments with divided leadership to the 

present day, where one department stands 

united under the leadership of Bert W. 

O’Malley, Jr., MD, Gabriel Tucker Professor 

and Chair, the faculty of Penn’s department 

of Otorhinolaryngology – Head and Neck 

Surgery have been true pioneers in the field 

and continue to make history and change 

lives for patients and the medical 

community at large. 

2003-Present 


serves as the Gabriel Tucker 


the Department of 

Otorhinolaryngology-Head 

and Neck Surgery 



Recent Grants, Awards and Publications 

Peer Reviewed Publications 

Ahn KJ, Passero, F, Crenshaw III EB. Otic 

mesenchyme expression of cre recombinase 

directed by the inner ear enhancer of the 

Brn4/Pou3f4 gene. Genesis. 2009;47:137-141. 

Altman KW, Desai SC, Moline J, de la Hoz R, 

Herbert R, Gannon PJ, Doty RL. Odor 

identification ability and self-reported upper 

respiratory symptoms in workers at the post- 

9/11 World Trade Center site. International 

Archives of Occupational and Environmental 

Health. 2010 [Epub ahead of print, PMID: 

20589388]. 

Antunes MB, Javia LR, Ransom ER, Kazahaya 

K. Salivary anlage tumor of the nasopharynx: A 

case report and review of the literature. 

International Journal of Pediatric 

Otorhinolaryngology. 2010. Accepted for 

publication, 2010. 

Atkins JH, Mirza N, Mandel JE. High impact 

report: Respiratory inductance plethysmography 

as a monitor of ventilation during laser ablation 

and balloon dilatation of subglottic tracheal 

stenosis. ORL Journal of Head and Neck 

Surgery. O’Malley BW Jr, (eds.) 2009;71(5): 

289-291. 

Atkins, JH, Mandel, JE, Weinstein, GS, Mirza, 

N. A pilot study of respiratory inductance 

plethysmography as a safe, noninvasive detector 

of jet ventilation under general anesthesia. 

Anesth Analg. Aug 2010. [Epub ahead of print]. 

Aynehchi B, Newman JG, Brooks JS. Dermoid 

cyst of the parotid gland. Ear, Nose & Throat 

Journal. 2010. 

Azadarmaki R, Mirza N, Soliman AM. 

Unilateral true vocal fold synkinesis presenting 

with airway obstruction. Annals Otology, 

Rhinology, Laryngology. 2009;118(8):587-91. 

Banks CA, Palmer JN, Chiu AG, O’Malley BW 

Jr, Woodworth BA, Kennedy DW. Endoscopic 

closure of CSF rhinorrhea: 193 cases over 21 

years. Otolaryngol Head Neck Surg. 

2009;140(6):826-33. Epub 2009 Feb 28.PMID: 

19467398 [PubMed - indexed for MEDLINE] 


Bar Ad V, Weinstein G, Dutta PR, Chalian A, 

Both S, Quon H. Gabapentin for the treatment 

of pain related to radiation-induced mucositis, 

in patients with head and neck tumors treated 

with intensity modulated radiation therapy 

(IMRT.) Head and Neck Journal. Feb 

2010;32(2):173-7. 

Barañano CF, Curé J, Palmer JN, Woodworth 

BA. Sternberg’s canal: fact or fiction? Am J 

Rhinol Allergy. 2009;Mar-Apr;23(2):167-71. 

Basu D, Nguyen TT, Montone KT, Zhang G, 

Wang LP, Diehl JA, Rustgi AK, Lee JT, 

Weinstein GS, Herlyn M. Evidence for 

mesenchymal-like sub-populations within 

squamous cell carcinomas possessing 

chemoresistance and phenotypic plasticity. 

Oncogene. Jul 2010;29(29): 4170-82. 

Basu, D, Truelson, JM, Weinstein, GS. 

Management of the neck with carotid artery 

involvement. www.emedicine.medscape.com 

2010. 

Becker DG, Ransom ER, Antunes MB, Guy C, 

Bloom JD. Surgical treatment of nasal 

obstruction in rhinoplasty (A CME Project). 

Aesthetic Surgery Journal. In press – accepted 

for publication. 

Benito J, Holsinger FC, Pérez-Martín A, Garcia 

D, Weinstein GS, Laccourreye O. Aspiration 

after supracricoid partial laryngectomy: 

Incidence, risk factors, management, and 

outcomes. Head Neck. 2010;In press. 

Bleier BS, Cohen NA, Chiu AG, O’Malley BW 

Jr, Doghramji L, Palmer JN. Endonasal laser 

tissue welding: first human experience. Am J 

Rhinol Allergy. 2010; 24(3):244-6. PMID: 

20537294 [PubMed - in process] 

Bleier BS, Cohen NM, Bloom JD, Palmer JN, 

Cohen NA. Laser Tissue Welding in Lung and 

Tracheobronchial Repair: An Animal Model. 

Chest. 2010;138(2):345-349. [Epub ahead of 

print] PMID: 20299627 [PubMed - as supplied 

by publisher] 

Bleier BS, Palmer JN. Cranial-base repair using 

endoscopic laser welding. Otolaryngol Clin 

North Am. 2009;42(5):901-6, xi.PMID: 


Bleier BS, Kofonow JM, Hashmi N, Chennupati 

SK, Cohen NA. Antibiotic eluting chitosan 

glycerophosphate implant in the setting of acute 

bacterial sinusitis: a rabbit model. Am J Rhinol 

Allergy. 2010;24(2):129-32. 

Bleier BS, Kennedy DW, Palmer JN, Chiu AG, 

Bloom JD, O’Malley BW Jr. Current 

management of juvenile nasopharyngeal 

angiofibroma: a tertiary center experience 1999- 

2007. Am J Rhinol Allergy. 2009;23(3):328-30. 

PMID: 19490810 [PubMed - indexed for 

MEDLINE] 

Bloom JD, Bleier BS, Mirza N, Chalian AA, 

Thaler ER. Factors predicting endoscopic 

exposure of Zenker’s Diverticulum. Annals of 

Otology, Rhinology & Laryngology. In press – 

accepted for publication. 

Bloom JD, Bleier BS, Goldstein SA, Carniol PJ, 

Palmer JN, Cohen NA. Laser Facial Nerve 

Welding in a Rabbit Model. Archives of Facial 

Plastic Surgery. Submitted for publication. 

Bloom JD, Ransom ER, Antunes MB, Becker 

DG. Quantifying the sharpness of osteotomes 

for dorsal hump reduction. Archives of Facial 

Plastic Surgery. Submitted for publication. 

Bromley SM, Doty RL. Olfaction in dentistry. 

Oral Diseases. 2010;16:221-224. 

Bruno CJ, Smith LP, Zur KB, Wade KC. 

Congenital subglottic cyst in a term neonate. 

Archives of Diseases in Children Fetal & 

Neonatal Edition. July 2009;94(4): F240. 

Calderón-Garcidueñas L, Franco-Lira M, 

Henriquez-Roldán C, Osnaya N, Monroy- 

Cazares S, Gonzalez-Maciel A, Reynoso-Robles 

R,Villarreal-Calderon R, Herritt L, Brooks D, 

Keefe S, Palacios-Moreno J, Villarreal-Calderon 

R, Torres-Jardón R, Medina-Cortina H, 

Delgado-Chávez R, Aiello-Mora M, Moronpot 

RR, Doty RL. Urban air pollution: Influences 

on olfactory function and pathology in exposed 

children and young adults. Experimental and 

Toxicological Pathology. 2010;62:91-102.

Chawla S, Kim S, Loevner LA, Quon H, Wang 

S, Mutale F, Weinstein G, Delikatny EJ, Poptani 

H. Proton and phosphorous MR spectroscopy 

in squamous cell carcinomas of the head and 

neck. Acad Radiol. Nov 2009;16(11): 1366-72. 

Chepeha DB, Malloy KM, Moyer JS, 

Chanowski EJ, Khariwala SS. Maxillomandibular-labial 

reconstruction: An 

autogenous transplant as an alternative to 

allogenic face transplantation. Plast Reconstr 

Surg. Accepted June 2010. 

Chepeha DB, Khariwala SS, Chanowski EJ, 

Zumsteg JW, Malloy KM, Moyer JS, Prince ME, 

Sacco AG, Lee JS. Thoracodorsal artery scapular 

tip autogenous transplant (Tdast): Vascularized 

bone with a long pedicle and flexible soft tissue. 

Arch Otolaryngol Head Neck Surg. Accepted 

May 2010. 

Cohen MA , Weinstein GS, O’Malley Jr. BW, 

Feldman M, and Quon H. Transoral Robotic 

Surgery (TORS) and human papillomavirus 

(HPV) status: Oncologic results. Head and 

Neck Surgery. In press. 

Cohen M, Kofonow J, Nayak JV, Palmer JN, 

Chiu AG, Leid JG, Cohen NA. Biofilms in 

chronic rhinosinusitis: a review. Am J Rhinol 

Allergy. 2009;23(3):255-60. Review.PMID: 


Cohen NA, Zhang S, Sharp DB, Tamashiro E, 

Chen B, Sorscher EJ, Woodworth BA. Cigarette 

smoke condensate inhibits transepithelial 

chloride transport and ciliary beat frequency. 

Laryngoscope. 2009;119(11):2269-74. 

Deutsch ES, Christenson T, Curry J, Hossain J, 

Zur K, Jacobs I. Multimodality education for 

airway endoscopy skill development. Ann Otol 

Rhinol Laryngol. 2009 Feb;118(2):81-6. 

Donaher JG, Healey EC, Zobell A. The effects of 

ADHD medication changes on a child who 

stutters. Perspectives on Fluency and Fluency 

Disorders. 2009;19:95-98. 


Doty RL. Sniffing out the truth about 

pheromones. New Scientist. 2010;2749:28-29. 

Doty RL, Crastnopol B. Correlates of 

chemosensory test malingering. Laryngoscope. 

2010; 8:707-11. 

Doty RL, Treem J, Tourbier I, Mirza N. A 

double-blind study of the influences of 

eszopiclone on dysgeusia and taste function. 

Pharmacology, Biochemistry and Behavior. 

Elsevier. 2009;94:312-318. 

Dunham B, Guttenberg M, Morrison W, Tom 

L. The histologic relationship of preauricular 

sinuses to auricular cartilage. Archives of 

Otolaryngology - Head and Neck Surgery. 

December 2009;135(12):1262-65. 

Dunham BD, Bilaniuk L, Judkins A, Zur KB. 

Bilateral nasal obstruction due to an intranasal 

craniopharyngioma. International Journal of 

Pediatric Otorhinolaryngology March 

2010;Extra 5(2): 57-62. 

Dunham, BP. Sinus Photoshop illustrations. 

Original artwork, 2006. 2(1), 2010 Notes: 

Artwork used in Winter 2010 Nurse Practitioner 

Newsletter, “Now Hear This!”, Division of 

Otolaryngology, The Children’s Hospital of 

Philadelphia. 

Feigenson K, Reid M, See J, Crenshaw III EB, 

Grinspan JB. Wnt signaling inhibits 

Oligodendrocyte differentiation in vitro and in 

vivo. Mol. Cell Neurosci., 2009;42(3):255-65. 

Greish K, Araki K, Li D, O’Malley BW Jr, 

Dandu R, Frandsen J, Capptello J, Ghandehari 

H. Silk-elastinlike protein polymer hydrogels for 

localized adenoviral gene therapy of head and 

neck tumors. Biomacromolecules. 2009;Aug 

10;10(8):2183-8. 

Greish K, Frandsen J, Scharff S, Gustafson J, 

Cappello J, Li D, O’Malley BW Jr, Ghandehari 

H. Silk-elastinlike protein polymers improve the 

efficacy of adenovirus thymidine kinase enzyme 

prodrug therapy of head and neck tumors. J 

Gene Med. 2010; Jul;12(7):572-9. 

Grossman, C.E., Zhu, T.C., Finlay, J.C., Malloy, 

K., O’Malley, Jr., B., Weinstein, G., Busch, T.M., 

Quon, H. Targeted laryngeal photodynamic 

therapy with a balloon diffusing light source. 

Photodiagnosis Photodyn Ther. Sep 

2010;7(3):158-161. 

Hahn S, Palmer JN, Purkey MT, Kennedy DW, 

Chiu AG. Indications for external frontal sinus 

procedures for inflammatory sinus disease. Am J 

Rhinol Allergy. 2009 May-Jun;23(3):342- 

7.PMID: 19490813 [PubMed - indexed for 

MEDLINE] 

Hashmi NK, Mandel JE, Mirza, N. Laryngeal 

mask airway in laryngoscopies: A safer 

alternative for the difficult airway. ORL. 

O’Malley BW Jr, (eds.) Karger, 2010; 71(6): 

342-346. 

Hekiert AM, Kofonow JM, Doghramji, L, 

Kennedy DW, Chiu AG, Palmer JN, Leid JG, 

Cohen NA. Biofilms correlate with TH1 

inflammation in the sinonasal tissue of patients 

with chronic rhinosinusitis. Otolaryngol Head 

Neck Surg. 2009.141(4):448-53. 

Hekiert AM, Cohen MB, Montone KT, Palmer 

JN, Govindaraj S. Ecthyma gangrenosum 

mimicking acute invasive fungal sinusitis in an 

immunocompromised patient. Ear Nose Throat 

J. 2010;89(6):262-7.PMID: 20556737 [PubMed - 

in process] 

Heuer GG, Kiefer H, Judkins AR, Belasco J, 

Biegel JA, Jackson EM, Cohen M, O’Malley BW 

Jr, Storm PB. Surgical treatment of a clival-C2 

atypical teratoid/rhabdoid tumor. J Neurosurg 

Pediatr. 2010; Jan;5(1):75-9. 

Kim S, Loevner LA, Quon H, Kilger A, 

Sherman E, Weinstein G, Chalian A, Poptani H. 

Prediction of response to chemoradiation 

therapy in squamous cell carcinomas of the 

head and neck using dynamic contrastenhanced 

MR imaging. AJNR Am J 

Neuroradiol. Feb 2010;31(2):262-8. 


OTORHINOLARYNGOLOGY - HEAD AND NECK SURGERY AT THE UNIVERSITY OF PENNSYLVANIA 

Lando T, Zur KB. Preliminary outcomes of 

cholesteatoma screening in children using nonecho-planar 

diffusion-weighted magnetic 

resonance imaging. Int J Pediatr 

Otorhinolaryngoly. March 2010;74(3):297-301. 

Article Review. Faculty of 1000 Medicine. 

May 2010. Electronic review. 

http://www.f1000medicine.com/article/ 

id/3079961/evaluation (May 4, 2010). 

Lee JYK, O’Malley BW Jr, Newman JG, 

Weinstein GS, Lega B, Diaz J, Grady MS. 

Transoral robotic surgery of craniocervical 

junction and atlantoaxial spine: a cadaveric 

study. J Neurosurg Spine. 2010;Jan;12(1):13-8. 

Lee JYK, Lega B, Bhowmick D, Newman JG, 

O’Malley BW Jr, Weinstein GS, Grady MS, 

Welch WC. DaVinci Robot-assisted transoral 

odontoidectomy for basilar invagination. 

ORL J Otorhinolaryngol Relat Spec. 

2010;Jun;72(2):91-5. 

Lee JYK, O’Malley BW Jr, Newman JG, 

Weinstein GS, Lega B, Diaz J, Grady MS. 

TransOral Robotic Surgery of the skull 

base: A cadaver and feasibility study. ORL J 

Otorhinolaryngol Relat Spec. 2010;Jul 

29;72(4):181-187. 

Lee WT, Rizzi M, Scharpf J, Lorenz RR, Saxton 

JP, Adelstein DJ, Esclamado RM. Impact of 

preepiglottic space tumor involvement on 

concurrent chemoradiationtherapy. American 

Journal of Otolaryngology. Jan-Feb 

2010;31(1):67-9. 

Liang J, Newman JG, Frank D, Chalian, A. 

Cervical unicentric Castleman disease 

presenting as a neck mass: Case report and 

review of the literature. Ear Nose and Throat 

Journal. 2009. 

Ma C, Quesnelle KM, Sparano A, Rao S, Park 

MS, Cohen MA, Wang Y, Samanta M, Kumar 

MS, Aziz MU, Naylor TL, Weber BL, 

Fakharzadeh SS, Weinstein GS, Vachani A, 

Feldman MD, Brose MS. Characterization 

CSMD1 in a large set of primary lung, head and 

neck, breast and skin cancer tissues. Cancer Biol 

Ther. May 2009;8(10): 907-16 

Mintzer DM, Zheng, S, Michiko, N, Newman, 

JG, Benito, M. Esthesioneuroblastoma 

(Olfactory Neuroblastoma) with ectopic ACTH 

syndrome: A multidisciplinary case presentation 

from the Joan Karnell Cancer Center of 

Pennsylvania Hospital. The Oncologist. 2010. 

10 WWW.UPHS.UPENN.EDU/PENNORL 

O’Malley, BW Jr, Quon, H, Weinstein, GS. 

TransOral Robotic Surgery (TORS) for 

parapharyngeal space tumors. ORL Otorhino 

and Related Spec. 2010; In press. 

Osborne C, Gabel R, Donaher, JG. The history 

of Division 4’s perspectives on fluency and 

fluency disorders. Perspectives on Fluency and 

Fluency Disorders. 2010;20:26-27. 

Purkey MT, Levine MS, Prendes B, Norman 

MF, Mirza N. Predictors of aspiration 

pneumonia following radiotherapy for head and 

neck cancer. Annals Otology, Rhinology, 

Laryngology. Smith, RJH (eds.) 2009;118:811. 

Quon H, O’Malley BW Jr, Weinstein GS. 


parapharyngeal space tumors. ORL. In press. 

Quon H, O’Malley BW Jr, Weinstein, GW. 

Postoperative adjuvant therapy following 


oropharyngeal carcinomas, rationale and 

current treatment approach. ORL. In press. 

Quon, H, O’Malley, B.W., Jr., Weinstein, G.S. 

Transoral robotic surgery and a paradigm shift 

in the management of oropharyngeal squamous 

cell carcinoma. Journal of Robotic Surgery. Aug 

2010;4(2):1863-2483. 

Quon, H, O’Malley, BW, Jr., Weinstein, GS. 

Transoral robotic surgery (TORS) for the head 

and neck: Current and future indications. 

International Journal of Head and Neck Surgery. 

September–December 2010;1(3):29-36. 

Ramakrishnan VR, Palmer JN. Prevention and 

management of orbital hematoma. Otolaryngol 

Clin North Am. 2010;43(4):789-800.PMID: 

20599083 [PubMed - in process] 

Ransom ER, Antunes MB, Smith LP. Jacobs IN. 

Microdebrider resection of acquired subglottic 

cysts: Case series and review of the literature. 


Otorhinolaryngology. December 

2009;73(12)1833-36. 

Recanzone GH, Cohen YE. Serial and parallel 

processing in the primate auditory cortex 

revisited. Behav. Brain Res. 2010;206:1-7 

Rizzi MD, Weil RJ, Lorenz RR. Severe transient 

hypertension after greater palatine foramen 

block in a patient taking midodrine. American 

Journal of Otolaryngology Jan-Feb 

2010;67(9):67-9. Epub 2009 April 23. 

Rizzi MD, Thorne MC, Zur KB, Jacobs IN. 

Laryngotracheal reconstruction with posterior 

costal cartilage grafts: outcomes at a single 

institution. Otolaryngol Head Neck Surg. 

2009;140(3):348-53. 

Roesch A, Fukunaga-Kalabis M, Schmidt EC, 

Zabierowski SE, Brafford PA, Vultur A, Basu D, 

Gimotty P, Vogt T, Herlyn M. A temporarily 

distinct subpopulation of slow-cycling 

melanoma cells is required for continuous 

tumor growth. Cell. 2010;141:583-594. 

Saito K, Araki K, Reddy N, Guang W, O’Malley 

BW Jr, Li D. Enhanced local dendritic cell 

activity and tumor-specific immunoresponse in 

combined radiofrequency ablation and 

interleukin-2 for the treatment of human head 

and neck cancer in a murine orthotopic model. 

Head Neck. 2010;Jul 22. 

Salinas NL, Jackson O, Dunham B, Bartlett SP. 

Anatomical dissection and modified Sihler stain 

of the lower branches of the facial nerve. Plastic 

and Reconstructive Surgery. December 

2009;124(6):1905-15. Published Photoshop 

illustration by Dr. Brian Dunham included in 

manuscript. 

Savitski A, Mesaros AC, Blair I, Cohen NA, 

Kreindler, JL. Secondhand smoke inhibits both 

CFTR and K+ channels in normal human 

bronchial epithelial cells. Resp. Res. 2009;10:120. 

Selber JC, Robb G, Serletti JM, Weinstein G, 

Weber R, Holsinger FC. Transoral robotic free 

flap reconstruction of oropharyngeal defects: a 

preclinical investigation.Plast Reconstr Surg. 

Mar 2010;125(3):896-900. 

Shaffer BT, Cohen MS, Bigelow DC, 

Ruckenstein MJ. Validation of a disease-specific 

quality-of-life instrument for acoustic neuroma: 

The Penn acoustic neuroma quality-of-life scale. 

Laryngoscope. 2010;120:1646-1654. 

Smith LP, Zur KB, Jacobs IN. Single-staged vs. 

double-staged laryngotracheal reconstruction. 

Archives of Otolaryngology Head Neck Surgery. 

January 2010;136(1): 60-65.

Smith LP, Chewaproug L, Spergel JM, Zur KB. 

Otolaryngologists may not be doing enough to 

diagnose pediatric eosinophilic esophagitis. 


Otorhinolaryngology. November 2009;73(11): 

1554-1557. Epub 2009 Sep 3. 

Smith LP, Otto SE, Wagner KA, Chewaproug L, 

Jacobs IN, Zur KB. Management of oral feeding 

in children undergoing airway reconstruction. 

Laryngoscope. 2009 May;119(5):967-73. 

Stephenson R, Houghton D, Sundarararjan S, 

Doty RL, Stern M, Xie SX, Siderowf A. Odor 

identification deficits are associated with 

increased risk of neuropsychiatric complications 

in patients with Parkinson’s disease. Mov 

Disord. 2010; Jul 28 (Epub ahead of print.) 

Stinton, N., Atif, M.A., Barkat, N. Doty, R.L. 

Influence of smell loss on taste function. 

Behavioral Neuroscience. 2010;124:256-264. 

Stricker PA, Rizzi MD, Schwartz AJ. Lingual 

tonsil. Anesthesiology. March 2010;112(3): 746. 

Suh JD, Ramakrishnan V, Palmer JN. Biofilms. 

Otolaryngol Clin North Am. 2010; 43(3):521-30, 

viii. PMID: 20525507 [PubMed - in process] 

Suh JD, Cohen NA, Palmer JN. Biofilms in 

chronic rhinosinusitis. Curr Opin Otolaryngol 

Head Neck Surg. 2010;18(1):27-31. 

Review.PMID: 19940770 [PubMed - indexed for 

MEDLINE] 

Tamashiro E, Cohen NA, Palmer JN, Lima WT. 

Effects of cigarette smoking on the respiratory 

epithelium and its role in the pathogenesis of 

chronic rhinosinusitis. Braz J Otorhinolaryngol. 

2009;75(6):903-7. Review.P MID: 20209295 

[PubMed - indexed for MEDLINE] Free Article 

Tamashiro E, Antunes MB, Palmer JN, Cohen 

NA, Anselmo-Lima WT. Implications of 

bacterial biofilms in chronic rhinosinusitis. Braz 

J Infect Dis. 2009;13(3):232-5. Review.PMID: 


Free Article 

Tamashiro E, Banks CA, Chen B, Gudis DA, 

Doghramji L, Myntti M, Chiu, AG, Cohen NA. 

In vivo effects of citric acid/zwitterionic 

surfactant (CAZS) cleansing solution on rabbit 

sinus mucosa. Am J Rhinol Allergy. 

2009;23(6):597-601. 


Thein D, Thalhammer J, Hartwig AC, Paul M, 

Crenshaw III EB, Lefebvre V, Wegner M, Sock 

E. The closely related Sox4 and Sox11 function 

as transcriptional regulators of survival during 

central nervous system development. J. 

Neurochem., 2010; In Press. 

Thorne MC, Zur KB. Transoral trans-stomal 

microdebrider excision of tracheal 

papillomatosis. Laryngoscope. 2009 

May;119(5):964-6. 

Weinstein GS, Quon H, O’Malley Jr. BW, Kim 

GG, Cohen MA. Selective neck dissection and 

de-intensified postoperative radiation and 

chemotherapy for Oropharyngeal Cancer: A 

Subset Analysis of the University of 

Pennsylvania TORS Trial. Laryngoscope. Sep 

2010;120(9):1749-55. 

Weinstein GS, O’Malley Jr. BW, Cohen MA, 

and Quon H. Transoral Robotic Surgery 

(TORS) for advanced oropharyngeal carcinoma. 

The Archives of Otolaryngology: Head and 

Neck Surgery. In press. 

Weinstein GS, O’Malley Jr. BW, Desai SC, 

Quon H. Transoral robotic surgery: does the 

ends justify the means? Curr Opin Otolaryngol 

Head Neck Surg. April 2009;17(2): 126-31. 

Notes: (GSW, BWO and SCD should be 

regarded as joint first authors). 

Welch KC, Thaler ER, Doghramji LL, Palmer 

JN, Chiu AG. The effects of serum and urinary 

cortisol levels of topical intranasal irrigations 

with budesonide added to saline in patients with 

recurrent polyposis after endoscopic sinus 

surgery. Am J Rhinol Allergy. 2010;24(1):26-8. 

PMID: 20109316 [PubMed - indexed for 

MEDLINE] 

Welch KC, Cohen MB, Doghramji LL, Cohen 

NA, Chandra RK, Palmer JN, Chiu AG. Clinical 

correlation between irrigation bottle 

contamination and clinical outcomes in postfunctional 

endoscopic sinus surgery patients. 

Am J Rhinol Allergy. 2009;23(4):401-4. PMID: 


Woodworth BA, Zhang S, Tamashiro E, 

Bhargave G, Palmer JN, Cohen NA. Zinc 

increases ciliary beat frequency in a calciumdependent 

manner. Am J Rhinol Allergy. 

2010;24(1):6-10. PMID: 20109308 [PubMed - 

indexed for MEDLINE] 

Xu L, Heldrich J, Wang H, Yamashita T, 

Miyamoto S, Uboh C, You Y, Bigelow D, 

Ruckenstein M, O’Malley BW Jr, Li D. A 

Controlled and sustained local gentamicin 

delivery system for inner ear applications. 

Otology & Neurotology 2010 In Press. 

Zhang S, Fortenberry JA, Cohen NA, Sorscher 

EJ, Woodworth BA. Comparison of vectorial 

ion transport in primary murine airway and 

human sinonasal air-liquid interface cultures, 

models for studies of cystic fibrosis, and other 

airway diseases. Am J Rhinol Allergy. 

2009;23(2):149-52. 

Zhang Z, O’Malley BW Jr, Doghramji L, 

Cucchiara AJ, Kennedy DW, Chiu AG, Cohen 

NA, Palmer JN. The role of asthma and biofilmforming 

bacteria in refractory chronic 

rhinosinusitis. Journal of Allergy and Clinical 

Immunology. In Press. 

Zur KB, Litman RS. Pediatric airway foreign 

body retrieval: Surgical and anesthetic 

perspectives. Pediatric Anesthesia. 

2009;19(s1):109-117. 

Zur KB, Lando T. Unilateral hearing loss is 

associated with worse speech-language scores in 

children. Lieu JE, Tye-Murray N, Karzon RK, 

Piccirillo JF Pediatrics 2010 Jun 125 (6):e1348- 

55. (article review). Faculty of 1000 Medicine 

June 2010. 

Books/Chapters 

Becker DG, Bloom JD, Gudis D. A patient 

seeking aesthetic revision rhinoplasty and 

correction of nasal obstruction. In: Becker, DG, 

ed. Otolaryngologic Clinics of North America – 

Surgical Management of Nasal Obstruction: 

Facial Plastic Surgery Perspective. 2009;42:557- 

565. 

Cahill AM, Jacobs IN. Surgical approaches to 

vascular anomalies of the pediatric airway. Clinics 

in Plastic Surgery - Vascular Anomalies Edition. 

Perlyn C, Greene A, eds. Elsevier Saunders, 

Philadelphia, PA. May 2011. In production. 

Cohen YE, Lee JH, Tsunada J, and Russ BE. 

Auditory categories in the non-human primate. 

In: Brudzynski, SM, ed. Handbook of 

Mammalian Vocalizations. 2010;487-493. 

Crawford JT, Ruckenstein MJ, Bedrosian J, 

Denys D. Cochlear Function. Otolaryngology, 

Facial Plastic Surgery. EMedicine, June 2010. 



Recent Grants, Awards and Publications (Continued) 

Doty RL. Trouble smelling? Bottom Line Health. 

Stamford, CT: Boardroom Press; 2010;9-11. 

Doty RL. The Great Mammalian Pheromone 

Myth. Baltimore: Johns Hopkins University Press; 

2010;296 pp. 

Elden LM, Wetmore RF, Potsic WP. 

Otolaryngologic disorders. In: Pediatric Surgery, 

7th Edition. Coran AG, Adzick NA, Krummel 

TM, Laberge J, Shamberger R, eds. Mosby, Inc. 

(an affiliate of Elsevier, Inc.), 2010-11. 

Elden LM. Otitis media: Diagnosis and 

management of acute otitis media and chronic 

otitis media with effusion. Pediatric 

Otolaryngology: Principles & Practice Pathways. 

New York: Thieme; 2011. 

Elden LM, Zur KB, eds. Congenital 

Malformations of the Head and Neck. New York: 

Springer; 2010. For Fall 2010 publication. 

Guss J, Ruckenstein MJ. Infections of the external 

ear. In: Cummings Otolaryngology Head and 

Neck Surgery. PW Flint, BH Haughey, VL Lund, 

JK Niparko, MA Richardson, KT Robbins, JR 

Thomas, eds. Mosby Elsevier. 2010;1944-1949. 

Jacobs IN. Congenital anomalies of the trachea 

and bronchii. Bluestone & Stool’s Pediatric 

Otolaryngology, 5th edition. Mandell DL, 

Rahbar R, eds. BC Decker, Inc. September 2009. 

In press. 

Jacobs IN, Pettignano MM, Pettignano R. 

Airway management. Perinatal and Pediatric 

Respiratory Care, 3rd ed. Walsh BK, Czervinske 

MP, DiBlasi RM, eds. Saunders, St. Louis, MO. 

2010;Chapter 15;220-245. 

Jacobs IN. Bronchoscopy. Fundamentals of 

Pediatric Surgery, 2nd edition. Mattei P, ed.. 

Springer, 2011. In production. 

Jacobs IN. Chronic cough in children. Pediatric 

Otolaryngology for Primary Care. American 

Academy of Pediatrics. 2011. 

Javia L, Jacobs IN. Airway intervention in the 

infant with a vascular anomaly. Clinics in Plastic 

Surgery. Elsevier. 2011. 

Javia LR, Dunham BP, Jacobs I. Congenital 

malformations of the trachea and bronchi. 

Pediatric Otolaryngology, 5th Ed. Bluestone C et 

al, eds. BC Decker. 2010. In press. Dr. Brian 

Dunham created original Photoshop 

illustrations for Figures 14 and 15. 


Miller CT, Cohen YE. Vocalization Processing. In: 

Ghazanfar, A and Platt, M, eds. Primate 

Neuroethology. 2010;237-256. 

O’Malley BW Jr, Weinstein, GS. Future 

Directions for TransOral Robotic Surgery 

(TORS): Telementoring and Telesurgery, 2009. 

O’Malley BW Jr, Li D, Abuzeid WM, Staecker, H. 

Fundamentals of molecular biology and gene 

therapy. In: Cummings et al. Otolaryngology – 

Head and Neck Surgery. 2010. Chapter Two. 

Rauch SD, Cohen MA, Ruckenstein MJ. 

Autoimmune inner ear disease. In: Cummings 

Otolaryngology Head and Neck Surgery. PW 

Flint, BH Haughey, VL Lund, JK Niparko, MA 

Richardson, KT Robbins, JR Thomas, eds. Mosby 

Elsevier, Page: 2164-2168, 2010. 

Ruckenstein MJ. Meniere’s Disease - Evidence 

and Outcomes. Plural Publishing.San Diego. 

April 2010. 

Shah M, Khan M, Doty RL. Olfactory central 

processing. In: Goldstein EB, ed. Encyclopedia of 

Perception Volume 2. Thousand Oaks, CA: 

2009;685-690. 

Weinstein, GS, O’Malley BW Jr. Editors, Trans 

Oral Robotic Surgery. In preparation 2010. 

Pleural Publishing, Inc., San Diego, CA. 2010. 

Wetmore RF, Potsic WP. Differential diagnosis of 

the neck masses. In: Cummings Otolaryngology 

Head & Neck Surgery. Flint PW, Haughey BH, 

Lund VJ, Niparko JK, Richardson MA, Robbins 

KT, Thomas JR, eds.. Mosby Elsevier, 2010;2812- 

2821. 

Zur KB. Reviewer, Faculty of 1000 Medicine 

(Faculty of 1000 Medicine is a unique online 

service where distinguished faculty of over 2400 

of the world’s top clinicians and researchers 

select, rate and evaluate the most important and 

influential articles, presenting a continuously 

updated, authoritative guide to the medical 

literature that matters.) 2010-Present. 

Zur KB, (Co-author) Introducing the AAO-HNS 

Expert Witness Guidelines. Published to the 

American Academy of Otolaryngology Head and 

Surgery Foundation’s (AAO-HNSF) online 

learning system. 2010-Present. 

Zur KB. Pediatric airway reconstruction and the 

voice. In: Clinical Management of Children’s 

Voice Disorders. Hartnick C, Boseley M, eds. 

Plural Publishing. March 2010; 189-11. This text 

is a shortened version of Pediatric Voice 

Disorders, specifically for speech-language 

pathologists and pediatric laryngologists working 

with children with voice disorders. s1:109 - 117 

Grants 

E. Bryan Crenshaw III, PhD, Development of 

Genetic and Stem Cell Approaches in the 

Cochlear Lateral Wall, National Institutes of 

Health, NIDCD R21 DC010918, 04/01/2010 - 

03/31/2012, 10% Effort, $275,000 direct total, 

$125,000 direct first year (E. Bryan Crenshaw III 

& John Germiller, Co-PIs) 

E. Bryan Crenshaw III, PhD, Audiological and 

Genetic Resource for Pediatric Hearing 

Research, National Institutes of Health, NIDCD 

R21-R33 DC008630-S1 (ARRA Supplement) 

7/17/09-6/30/11, No Effort, $98,603 direct total, 

Year 1-2. 

E. Bryan Crenshaw III, PhD, New Program 

Development Award, Intellectual and 

Developmental Disability Research Centers, 

National Institutes of Health, NICHD 

HD026979-20S1 7/1/09-6/30/10, No Effort, 

$50,000 direct total (Yudkoff/Golden, PI; E. 

Bryan Crenshaw III, Co-I). 

Natasha Mirza, MD, Veterans Affairs 

Competitive Pilot Project Fund, $50,000.00 for a 

study entitled “A Prospective Randomized Study 

of Financial Incentives for Smoking Cessation in 

Head & Neck Cancer Patients”. Co-investigators: 

Ghosh A, Ransom E, Bewley A. 

Bert W. O’Malley, Jr. MD, Co-investigator, RO1, 

Thioredoxin Reductase 1 as a Radio/ 

Chemosensitization Target in Head and Neck 

Cancer. 

Bert W. O’Malley Jr., MD, Principal Investigator, 

RO1, Molecular Analysis of Oral Squamous Cell 

Carcinoma Tumor Invasion. 

Bert W. O’Malley, Jr., MD, R01, Co-Investigator 

Engineering Polymers for Gene Therapy of 

Head and Neck Cancer.

Jessica Shen, MD, Inflammatory Cytokine 

Modulation of Sinonasal Ciliary Dynamics. 

American Rhinologic Society Resident Research 

Grant (2010) Marcelo Antunes, M.D., “Tobacco 

smoke mediated induction of upper airway 

bacterial biofilms. American Academy of 

Otolaryngology Head and Neck Surgery 

Resident Research Grant (2010) 

Gregory S. Weinstein, MD. A Single Center 

Retrospective Investigation of the use of the da 

Vinci Surgical System in Transoral Surgery 

(TORS) Targeting Patients with Oral and 

Laryngopharyngeal benign and malignant 

lesions , Intuitive Surgical, Inc. , 5/2008-2/2009 

(Gregory Weinstein, M.D., PI), $126,000/annual 

direct costs, 1% effort (Role in grant: PI) 

Faculty and Resident Awards and Honors 

Penn Medicine’s Department (Ear Nose and 

Throat) was number 7 in the country as rated 

by USNews & World Report. 

Yale Cohen, PhD was appointed a Review 

Editor of Frontiers in Systems Neuroscience. 

Yale Cohen, PhD is under contract by Springer- 

Verlag to produce an edited volume entitled 

Neural Correlates of Auditory Cognition. 

Lisa M. Elden, MD was elected as a Member of 

the ASP Membership Committee. 

Lisa M. Elden, MD is a Member of the Editorial 

Board of ORL - Journal of Oto-Rhino- 

Laryngology and Its Related Specialties. 

Lisa M. Elden, MD is the CHOP Division 

Representative, Pediatric National Surgical 

Quality Improvement Program (NSQIP 

sponsored by the American College of 

Surgeons). 

Ian N. Jacobs, MD was named an Honorary 

Lifetime Member of the Israeli Society of 

Otolaryngology/Head and Neck Surgery. 

Ken Kazahaya, MD, MBA is a Member of the 

AAO-HNS, Infectious Disease Committee. 

Natasha Mirza, MD is a Member of the newlyestablished 

Philadelphia Laryngological 

Association. 


Jason G. Newman, MD received the 2010 Joseph 

P. Atkins Resident Teaching Award, University of 

Pennsylvania. 

James Palmer, MD was appointed Visiting 

Professor at: 

• Emory University, Atlanta 

• Sun-Yat Sen University, Guangzhou China 

• Rhinocamp V, Bodrum, Turkey 

James Palmer, MD completed his term as 

President of the International Society on 

Infection and Allergy of the Nose (ISIAN) 

Geneva, Switzerland. 

James Palmer, MD was the Executive Course 

Director of the Penn International Endoscopic 

Sinus and Skull Base Course. 

James Palmer, MD was a member of the Faculty 

of the Advanced Rhinology and Endoscopic 

Skull Base Surgery Courses -- Sao Paulo, Brazil; 

New York Rhinology Update. 

Gregory S. Weinstein, MD is one of the five 

founding members of the Society of Robotic 

Surgeons (SRS) and served as First President 

(2009-2010.) 

Gregory S. Weinstein, MD served as Co-Editor 

for the Journal of Robotic Surgery from 2009- 

Present. 

Gregory S. Weinstein MD was appointed to the 

Editorial Board, ENT Masterclass from 2010- 

Present. 

Gregory S. Weinstein, MD served as Co- 

Director of the World Robotic Symposium and 

the First Annual Meeting of the Society of 

Robotic Surgeons, the Florida Hospital 

Association Global Robotics Institute and the 

Society of Robotic Surgeons. This four-day 

multispecialty symposium on all aspects of 

robotic surgery was held in April 2010 in 

Orlando Florida. 

News 

A new comprehensive Thyroid Center has 

opened at the Children’s Hospital of 

Philadelphia. Services available at the Center 

include endocrinology, ultrasonography/ 

interventional radiology, cytopathology/ 

pathology, anesthesiology and sedation, and 

surgical services. The Center is organized under 

Dr. Andrew Bauer, a pediatric endocrinologist 

from Walter Reed. Diagnostic ultrasonography 

is performed at CHOP and if necessary, a fineneedle 

aspiration may be arranged with sedation 

or anesthesia and interventional radiology. The 

specimens are reviewed by cytopathogists for 

adequacy and diagnosis. Surgical services are 

provided by Dr. Scott Adzick (Pediatric 

Surgery) and Dr. Ken Kazahaya (Pediatric 

Otolaryngology). 

A new Endoscopy Procedure Suite has been 

established at the Perelman Center for Advanced 

Medicine. Here, laryngological and esophageal 

procedures including laser procedures, balloon 

dilatations, injections, bronchoscopies and 

esophagoscopies are performed under minimal 

anesthesia, with quick recovery. 

Please send Alumni news and updates to 

Bonnie Rosen at 

Bonnie.rosen@uphs.upenn.edu 

or mail to 

Bonnie Rosen, CME Coordinator 

Penn Medicine 

Department of Otorhinolaryngology – 

Head and Neck Surgery 

3400 Spruce Street, 5 Ravdin 

Philadelphia, PA 19104 



The 1870 Society 

Since 1870, the Department of Otorhinolaryngology at the 

University of Pennsylvania has been in formal existence, 

making it one of the oldest departments and residencies in 

the country. The department is proud of its tradition of 

excellence in patient care, education and research that has 

continued to flourish for well over a century. Our 

educational mission centers on the residency program, 

and the priority of our residency program is to train 

outstanding clinicians and surgeons who have an in-depth 

exposure and base line expertise in all areas of clinical 

Otorhinolaryngology - Head and Neck Surgery. Every 

donation we receive helps us to make advancements in our 

specialty. It is with these goals in mind that we have 

established our newly-formed 1870 Society to support 

residency educational and research programs. 

Join the 1870 Society 

The 1870 Society is our prestigious group of alumni, 

faculty and friends who support the Department of 

Otorhinolaryngology - Head and Neck Surgery with a gift 

of $1,870 or more. Support for our new society allows us 

the flexibility to pursue new initiatives and innovative 

programs that directly benefit residents, faculty and patient 

care. Our residents are one of the primary strengths of our 

program and are an integral part of our past, present, and 

future success. Our continued growth and development is 

centered on the objective of enhancing our teaching 

curriculum. 

We hope you will consider becoming a member of the 1870 

Society by celebrating the rich history of the Department of 

Otorhinolaryngology - Head and Neck Surgery and by 

supporting our three-part mission: 

• to provide outstanding clinical care for our patients 

• to create a learning environment that will allow for 

training of the finest students, residents and fellows in 

the country 

• to engage in clinical and basic research that is at the 

cutting edge of our specialty 

For more information about the 1870 Society, please contact: 

Jean Liverman 

jean.liverman@uphs.upenn.edu 

Phone: 215.349.5383 


Opportunities for Giving 

Private support for the Department of Otorhinolaryngology – 

Head and Neck Surgery can facilitate faculty development, the 

training of a young doctor, enhanced patient care and/or 

research. Thank you for considering a gift that reflects the value 

of your experience to help realize our mission. 

Please make your check payable to The Trustees of the 

University of Pennsylvania and mail it to: 

Jean Liverman 

Otorhinolaryngology - Head and Neck Surgery 

The Hospital of the University of Pennsylvania 


Philadelphia, PA 19104-4283 

If you would like to direct your donation to a specific division 

or area of research, please let us know. 

“Tell me and I forget. 

Teach me and I remember. 

Involve me and I learn.” 

-Benjamin Franklin

A Celebration of the FDA 

Approval of TransOral 

Robotic Surgery (TORS) 

April 2010 

Executive Leadership at Penn with Bert W. O'Malley, Jr., MD and 

Gregory S. Weinstein, MD 

(Left to right) Bert W. O'Malley, Jr., MD, Anne O'Malley, Susan Weinstein, MD, 


(Left to right) Bert W. O'Malley, Jr., MD, Cynthia Miller 

Resident Graduation 

June 2010 

(Left to right) Brian T. Shaffer, MD, Marc A. Cohen, MD, 

Michael J. Ruckenstein, MD, Jason D. Bloom, MD, Jason M. Leibowitz, MD 


International Visitors 2010 

(Left to right) Wai-kuen Ho, MD, University of Hong Kong, 

Bert W. O'Malley, Jr., MD, William Wei, MD, University of Hong Kong, 


5th Annual David Myers 

Distinguished Lectureship 

June 2010 

(Left to right) H. Bryan Neel III, MD, PhD, Bert W. O'Malley, Jr., MD, 

Eugene N. Myers, MD 

Women in Otorhinolaryngology 

Clinical Research Roundtable 

October 2010 

(Left to right) Natasha Mirza, MD, FACS; Marsha S. Brose, MD, PhD; Erica R. 

Thaler, MD; Bert W. O’Malley, Jr., MD; Kelly M. Malloy, MD; Soo Kim Abboud, MD 


DEPARTMENT OF OTORHINOLARYNGOLOGY - HEAD AND NECK SURGERY 

This newsletter is published by the University of Pennsylvania 

Department of Otorhinolaryngology - Head and Neck Surgery 


Philadelphia, PA 19104 

Newsletter Co-Editors 


Gabriel Tucker Professor and Chair 

Co-Director, The Center for Head and Neck Cancer 

Co-Director, The Center for Cranial Base Surgery 


Professor and Vice Chair 

Director, Division of Head and Neck Surgery 

Co-Director, The Center for Head and Neck Cancer 



2010-2011 CALENDAR OF CME AND SPECIAL EVENTS 

November 2-7, 2010 

5th International Update Course: Otolaryngology Underwater 

Plaza Resort Bonaire, Netherland Antilles 

Course Directors: David W. Kennedy, MD 

and Bert W. O’Malley, Jr., MD 

February 18-20, 2011 

17th Annual Advances in Diagnosis and Treatment 

of Sleep Apnea and Snoring 

Disney Boardwalk Inn Resort, Orlando, Florida 

Presented by the University of Pennsylvania Department of 

Otorhinolaryngology – Head and Neck Surgery and Division of 

Sleep Medicine and the University of California, San Francisco 

Department of Otolaryngology – Head and Neck Surgery 

Course Directors: Richard J. Schwab, MD, 

Andrew N. Goldberg, MD, MSCE, and Eric J. Kezirian, MD, MPH 

March 10-12, 2011 

PENN International Rhinology and Skull Base Dissection Course 

The Westin Philadelphia 

Course Directors: Bert. W. O’Malley, Jr., MD, David W. Kennedy, MD, 

James N. Palmer, MD, Noam A. Cohen, MD, PhD, M. Sean Grady, MD, 

and John Y.K. Lee, MD 

Featuring the Penn Distinguished Skull Base Professorship: 

Theodore T. Schwartz, MD and Heinz Stammberger, MD 

Non-Profit 

Organization 

U.S. Postage 

Paid 

Permit No. 2563 

Philadelphia, PA 

FOR MORE INFORMATION: 

Phone: 215-349-5382 

Fax: 215-662-4515 

Email: cathy.lafferty@uphs.upenn.edu 

Visit us on the Web at http://www.uphs.upenn.edu/pennorl

Chairman's Note - Penn Medicine - University of Pennsylvania

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