20 - World Journal of Gastroenterology

More documents

Recommendations

Info

stress in alcohol toxicity. Free Radic Biol Med 1989; 7: 537-539 132 Thiele GM, Duryee MJ, Freeman TL, Sorrell MF, Willis MS, Tuma DJ, Klassen LW. Rat sinusoidal liver endothelial cells (SECs) produce pro-fibrotic factors in response to adducts formed from the metabolites of ethanol. Biochem Pharmacol 2005; 70: 1593-1600 133 Tworek BL, Wiegert RL, Jeanette JP, Tuma DJ, Casey CA. Differential effects of monensin on asialoglycoprotein receptor function after short-term ethanol administration. Biochem Pharmacol 1998; 55: 1603-1609 134 Tworek BL, Tuma DJ, Casey CA. Decreased binding of asialoglycoproteins to hepatocytes from ethanol-fed rats. Consequence of both impaired synthesis and inactivation of the asialoglycoprotein receptor. J Biol Chem 1996; 271: 2531-2538 135 McCashland TM, Tuma DJ, Sorrell MF, Casey CA. Zonal differences in ethanol-induced impairments in hepatic receptor binding. Alcohol 1993; 10: 549-554 136 McVicker BL, Casey CA. Effects of ethanol on receptormediated endocytosis in the liver. Alcohol 1999; 19: 255-260 137 McVicker BL, Tuma DJ, Kubik JA, Hindemith AM, Baldwin CR, Casey CA. The effect of ethanol on asialoglycoprotein receptor-mediated phagocytosis of apoptotic cells by rat hepatocytes. Hepatology 2002; 36: 1478-1487 138 Aziz-Seible RS, McVicker BL, Kharbanda KK, Casey CA. Cellular fibronectin stimulates hepatocytes to produce factors that promote alcohol-induced liver injury. World J Hepatol 2011; 3: 45-55 139 Gillis SE, Nagy LE. Deposition of cellular fibronectin increases before stellate cell activation in rat liver during ethanol feeding. Alcohol Clin Exp Res 1997; 21: 857-861 140 de la M Hall P, Lieber CS, DeCarli LM, French SW, Lindros KO, Järveläinen H, Bode C, Parlesak A, Bode JC. Models of alcoholic liver disease in rodents: a critical evaluation. Alcohol Clin Exp Res 2001; 25: 254S-261S 141 Sottile J, Shi F, Rublyevska I, Chiang HY, Lust J, Chandler J. Fibronectin-dependent collagen I deposition modulates the cell response to fibronectin. Am J Physiol Cell Physiol 2007; 293: C1934-C1946 142 Aziz-Seible RS, Lee SM, Kharbanda KK, McVicker BL, Casey CA. Ethanol feeding potentiates the pro-inflamma- WJG|www.wjgnet.com Aziz-Seible RS et al . Fibronectin and alcoholic liver disease tory response of kupffer cells to cellular fibronectin. Alcohol Clin Exp Res 2011; 35: 717-725 143 Tsukamoto H. Cytokine regulation of hepatic stellate cells in liver fibrosis. Alcohol Clin Exp Res 1999; 23: 911-916 144 Naito M, Hasegawa G, Ebe Y, Yamamoto T. Differentiation and function of Kupffer cells. Med Electron Microsc 2004; 37: 16-28 145 Martin J, Eynstone L, Davies M, Steadman R. Induction of metalloproteinases by glomerular mesangial cells stimulated by proteins of the extracellular matrix. J Am Soc Nephrol 2001; 12: 88-96 146 Rath PC, Aggarwal BB. TNF-induced signaling in apoptosis. J Clin Immunol 1999; 19: 350-364 147 Locksley RM, Killeen N, Lenardo MJ. The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell 2001; 104: 487-501 148 Kapila YL, Wang S, Dazin P, Tafolla E, Mass MJ. The heparin-binding domain and V region of fibronectin regulate apoptosis by suppression of p53 and c-myc in human primary cells. J Biol Chem 2002; 277: 8482-8491 149 Marastoni S, Ligresti G, Lorenzon E, Colombatti A, Mongiat M. Extracellular matrix: a matter of life and death. Connect Tissue Res 2008; 49: 203-206 150 Kapila YL, Kapila S, Johnson PW. Fibronectin and fibronectin fragments modulate the expression of proteinases and proteinase inhibitors in human periodontal ligament cells. Matrix Biol 1996; 15: 251-261 151 Wells RG. Cellular sources of extracellular matrix in hepatic fibrosis. Clin Liver Dis 2008; 12: 759-768, viii 152 Zeisberg M, Yang C, Martino M, Duncan MB, Rieder F, Tanjore H, Kalluri R. Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition. J Biol Chem 2007; 282: 23337-23347 153 Klassen LW, Thiele GM, Duryee MJ, Schaffert CS, DeVeney AL, Hunter CD, Olinga P, Tuma DJ. An in vitro method of alcoholic liver injury using precision-cut liver slices from rats. Biochem Pharmacol 2008; 76: 426-436 154 Meng Q. Three-dimensional culture of hepatocytes for prediction of drug-induced hepatotoxicity. Expert Opin Drug Metab Toxicol 2010; 6: 733-746 S- Editor Tian L L- Editor O’Neill M E- Editor Ma WH 2499 May 28, 2011|Volume 17|Issue 20|
Online Submissions: http://www.wjgnet.com/1007-9327office wjg@wjgnet.com doi:10.3748/wjg.v17.i20.2500 Natalia A Osna, MD, PhD, Series Editor Mechanisms of alcohol-mediated hepatotoxicity in humanimmunodeficiency-virus-infected patients Gyongyi Szabo, Samir Zakhari Gyongyi Szabo, Department of Medicine, LRB-208, University of Massachusetts Medical School, Worcester, MA 01605, United States Samir Zakhari, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, United States Author contributions: Szabo G and Zakhari S contributed equally to writing this review. Correspondence to: Gyongyi Szabo, MD, PhD, Professor, Associate Dean for Clinical and Translational Sciences, Director, MD/PhD Program, Vice Chair for Research, Department of Medicine, LRB-208, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, United States. gyongyi.szabo@umassmed.edu Telephone: +1-508- 8565275 Fax: +1-508- 8564770 Received: January 21,2011 Revised: April 19, 2011 Accepted: April 26, 2011 Published online: May 28, 2011 Abstract Clinical observations have demonstrated that excessive chronic alcohol use negatively affects human immunodeficiency virus (HIV) infection and contributes to the liver manifestations of the disease, even in HIV monoinfection. HIV/hepatitis C virus (HCV) co-infection is associated with increased progression of HVC liver disease compared to HCV infection alone, and both of these are negatively affected by alcohol use. Recent data suggest that alcohol use and HIV infection have common targets that contribute to progression of liver disease. Both HIV infection and chronic alcohol use are associated with increased gut permeability and elevated plasma levels of lipopolysaccharide; a central activator of inflammatory responses. Both alcoholic liver disease and HIV infection result in non-specific activation of innate immunity, proinflammatory cytokine cascade upregulation, as well as impaired antigen presenting cell and dendritic cell functions. Finally, alcohol, HIV and antiretroviral therapy WJG|www.wjgnet.com 2500 World J Gastroenterol 2011 May 28; 17(20): 2500-2506 ISSN 1007-9327 (print) ISSN 2219-2840 (online) © 2011 Baishideng. All rights reserved. affect hepatocyte functions, which contributes to liver damage. The common targets of alcohol and HIV infection in liver disease are discussed in this mini-review. © 2011 Baishideng. All rights reserved. TOPIC HIGHLIGHT Key words: Hepatitis C virus; Hepatitis B virus; Liver; Intestine; Inflammation Peer reviewers: Julian Swierczynski, MD, PhD, Professor, Department of Biochemistry, Medical University of Gdansk, 80-211 Gdansk, Poland; Luis Bujanda, PhD, Professor, Departament of Gastroenterology, CIBEREHD, University of Country Basque, Donostia Hospital, Paseo Dr. Beguiristain s/n, 20014 San Sebastián, Spain Szabo G, Zakhari S. Mechanisms of alcohol-mediated hepatotoxicity in human-immunodeficiency-virus-infected patients. World J Gastroenterol 2011; 17(20): 2500-2506 Available from: URL: http://www.wjgnet.com/1007-9327/full/v17/i20/2500.htm DOI: http://dx.doi.org/10.3748/wjg.v17.i20.2500 INTRODUCTION The life expectancy of patients infected with human immunodeficiency virus (HIV) has been prolonged, therefore, liver diseases have assumed far greater importance as a cause of morbidity and mortality in these patients. Antiretroviral therapy (ART) used by patients who have HIV infection is often hepatotoxic. In addition, patients who have HIV often are co-infected with hepatotropic viruses such as hepatitis B and C viruses; factors that are damaging to the liver. Furthermore, chronic alcohol consumption causes injury to the liver and may result in more rapid progression to cirrhosis, end-stage liver disease, and hepatocellular carcinoma in co-infected patients. This review addresses the interactions between these factors that result in furthering liver damage. May 28, 2011|Volume 17|Issue 20|
Page 1 and 2:
World Journal of Gastroenterology W
Page 3 and 4:
Robert JL Fraser, Daw Park Jacob Ge
Page 5 and 6: Italy Donato F Altomare, Bari Piero
Page 7 and 8: Fernando Azpiroz, Barcelona Ramon B
Page 9 and 10: S Contents EDITORIAL TOPIC HIGHLIGH
Page 11 and 12: Contents APPENDIX FLYLEAF EDITORS F
Page 13: Online Submissions: http://www.wjgn
Page 17 and 18: Mandrekar P. Epigenetics and alcoho
Page 23 and 24: Moghe A et al . Altered nutrients,
Page 25: Moghe A et al . Altered nutrients,
Page 28 and 29: James SJ. Intracellular S-adenosylh
Page 36 and 37: Pathol 2008; 214: 199-210 14 Alexak
Page 38 and 39: 69: 562-573 91 Murphy FR, Issa R, Z
Page 45: Aziz-Seible RS et al . Fibronectin
Page 48 and 49: mechanisms accounted for by autoimm
Page 50 and 51: extensively used in alcohol researc
Page 52 and 53: to autocrine TNF-a signaling after
Page 54 and 55: Sondek J, Zuobi-Hasona K, Aukhil I.
Page 58 and 59: HIV, VIRAL HEPATITIS AND ALCOHOL US
Page 60 and 61: Table 1 Common mechanisms of liver/
Page 62 and 63: perpermeability and endotoxemia pri
Page 70 and 71: metabolism. Nature 2009; 458: 1131-
Page 75 and 76: Mercer DF. Hepatitis and alcohol ef
Page 77 and 78: Online Submissions: http://www.wjgn
Page 79 and 80: Dolganiuc A. Role of lipid rafts in
Page 93 and 94: Online Submissions: http://www.wjgn
Page 95: Lakner AM et al . microRNAs and liv
Page 99 and 100: Lakner AM et al . microRNAs and liv
Page 102 and 103: in alcoholic liver steatosis [39,40
Page 105 and 106: Suh YG et al . HSCs and innate immu
Page 107 and 108:
Suh YG et al . HSCs and innate immu
Page 109 and 110:
Online Submissions: http://www.wjgn
Page 111 and 112:
Schaffert CS et al . MGST1: Friend
Page 113 and 114:
Schaffert CS et al . MGST1: Friend
Page 115 and 116:
Page 117 and 118:
Bardag-Gorce F. Proteasome inhibito
Page 119 and 120:
Bardag-Gorce F. Proteasome inhibito
Page 121 and 122:
Oh BY et al . siRNA therapy in colo
Page 123 and 124:
A Livin expression (%) 120 100 80 6
Page 125:
Tumor volume (cm 3 ) Oh BY et al .
Page 128 and 129:
M, Coggi G, Bosari S. Inhibitors of
Page 130 and 131:
Institute, UPMC Montefiore, 7 South
Page 132 and 133:
A B C D E Figure 1 Change in coloni
Page 135 and 136:
Jiang HP et al . Differential prote
Page 137 and 138:
Page 139 and 140:
A B C Vespasiani Gentilucci U et al
Page 141 and 142:
Vespasiani Gentilucci U et al . Non
Page 143 and 144:
Page 145 and 146:
Instructions to authors ISSN and EI
Page 147 and 148:
Instructions to authors used rather
Page 149:
Instructions to authors Chaoyang Di
show all

20 - World Journal of Gastroenterology

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?