10.05.2013 Views

¿El estradiol es un carcinógeno mutagénico genotóxico?

¿El estradiol es un carcinógeno mutagénico genotóxico?

¿El estradiol es un carcinógeno mutagénico genotóxico?

SHOW MORE
SHOW LESS

Create successful ePaper yourself

Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.

80. Ursin G, London S, Stanczyk FZ, Gentzschein E, Paganini-Hill<br />

A, Ross RK, Pike MC. A pilot study of urinary <strong>es</strong>trogen metabolit<strong>es</strong><br />

(16α-OHE 1 and 2-OHE 1) in postmenopausal women with and without<br />

breast cancer. Environ Health Perspect 1997; 105S: 601-605.<br />

81. Tsutsui T, Suzuki N, Fukuda S, Sato M, Maisumi H, McLachlan<br />

JA, Barrett JC. 17β-Estradiol-induced cell transformation and aneuploidy<br />

of Syrian hamster embryo cells in culture. Carcinogen<strong>es</strong>is<br />

1987; 8: 1715-1719.<br />

82. Barrett JC, Wong A, McLachlan JA. Diethylstilb<strong>es</strong>trol induc<strong>es</strong><br />

neoplastic transformation without measurable gene mutation at two<br />

loci. Science 1981; 212: 1402-1404.<br />

83. Barrett JC, Tsutsui T. Mechanisms of <strong>es</strong>trogen-associated carcinogen<strong>es</strong>is.<br />

In: Huff J, Boyd J, Barrett JC (eds) Cellular and Molecular<br />

Mechanisms of Hormonal Carcinogen<strong>es</strong>is: Environmental Influenc<strong>es</strong>.<br />

Wiley-Liss, New York, 1996; 105-112.<br />

84. Tsutsui T, Maizumi H, McLachlan JA, Barrett JC. Aneuploidy<br />

induction and cell transformation by diethylstilb<strong>es</strong>trol: a possible<br />

chromosomal mechanism in carcinogen<strong>es</strong>is. Cancer R<strong>es</strong> 1983; 43:<br />

3814-3821.<br />

85. Tsutsui T, Barrett JC. Neoplastic transformation of cultured<br />

mammalian cells by <strong>es</strong>trogens and <strong>es</strong>trogen-like chemicals. Environ<br />

Health Perspect 1997; 105: 619-324.<br />

86. Endo S, Metzler M, Hieber L. Nonrandom karyotypic chang<strong>es</strong><br />

in a spontaneously immortalized and tumorigenic Syrian hamster<br />

embryo cell line. Carcinogen<strong>es</strong>is 1994; 15: 2387-2390.<br />

87. Lengauer C, Kinzler KW, Vogelstein B. Genetic instabiliti<strong>es</strong> in<br />

human cancers. Nature 1998; 396: 643-649.<br />

88. Li JJ, Nandi S, Li SA. Hormon<strong>es</strong> and carcinogen<strong>es</strong>is: laboratory<br />

studi<strong>es</strong>. In: Becker KL (ed). Principl<strong>es</strong> and Practice of Endocrinology<br />

and Metabolism. J.B. Lippincott, New York, 1995; 1856-1861.<br />

89. Li JJ, Li SA. Estrogen carcinogen<strong>es</strong>is in the hamster kidney: a<br />

hormone-driven multi-step proc<strong>es</strong>s. In: Huff J, Boyd J, Barrett JC (eds)<br />

Cellular and Molecular Mechanisms of Hormonal Carcinogen<strong>es</strong>is:<br />

Environmental Influenc<strong>es</strong>. Wiley-Liss, Philadelphia, 1996; 255-267.<br />

90. Li JJ. Perspectiv<strong>es</strong> in hormonal carcinogen<strong>es</strong>is. Animal models<br />

to human disease. In: Huff J, Boyd J, Barrett JC (eds) Cellular and<br />

Molecular Mechanisms of Hormonal Carcinogen<strong>es</strong>is: Environmental<br />

Influenc<strong>es</strong>. Wiley-Liss, Philadelphia, 1996; 447-454.<br />

91. Hou X, Li JJ, CHen W, Li SA. Estrogen-induced proto-oncogene<br />

and suppr<strong>es</strong>sor gene expr<strong>es</strong>sion in the hamster kidney: significance<br />

for <strong>es</strong>trogen carcinogen<strong>es</strong>is. Cancer R<strong>es</strong> 1961; 56: 2616-2620.<br />

92. Li JJ. Sex hormon<strong>es</strong> and neoplastic transformation. In: Li JJ, Li<br />

SA, Gustafsson JA, Nandi S, Sekely LI (eds) Hormonal Carcinogen<strong>es</strong>is<br />

II. Springer-Verlag, New York, 1996; 280-282.<br />

93. Li JJ, González Z, Banerjeee S, Banerjee SK, Li SA. Estrogen<br />

carcinogen<strong>es</strong>is in the hamster kidney: role of cytotoxicity and cell proliferation.<br />

Environ Health Perspect 1993; 101 [Suppl 5]: 259-264.<br />

94. Li JJ, Li SA. Estrogen carcinogen<strong>es</strong>is in hamster tissu<strong>es</strong>: a critical<br />

review. Endocr Rev 1990; 11: 524-531.<br />

95. Li JJ, Hou X, Banerjee SK, Liao DZ, Maggouta F, Norris JS, Li<br />

SA. Overexpr<strong>es</strong>sion and amplification of c-myc in the Syrian hamster<br />

kidney during <strong>es</strong>trogen carcinogen<strong>es</strong>is: a probable critical role in neoplastic<br />

transformation. Cancer R<strong>es</strong> 1999; 59: 2340-2346.<br />

96. Li SA, Klicka JK, Li JJ. Estrogen 2-/4-hydroxylase activity,<br />

catechol <strong>es</strong>trogen formation and implications for <strong>es</strong>trogen carcinogen<strong>es</strong>is.<br />

Cancer R<strong>es</strong> 1985; 45: 181-185.<br />

97. Li SA, Klicka JK, Li JJ. Regulation of <strong>es</strong>trogen 2-/4-hydroxylase<br />

activity in hamster kidney by <strong>es</strong>trogens and androgens. Endocrinology<br />

1986; 119: 1810-1815.<br />

Acta<br />

Obstetricia<br />

et<br />

Gynecologica<br />

98. Li JJ, Purdy RH, Appelman EH, Klicka JK, Li SA. Catechol formation<br />

of fluoro- and bromo-substituted <strong><strong>es</strong>tradiol</strong> by hamster liver microsom<strong>es</strong>:<br />

evidence for dehalogenation. Mol Pharmacol 1985; 27: 559-565.<br />

99. DiAugustine RP, Walker M, Li SA, Li JJ. DNA adduct profil<strong>es</strong><br />

in hamster kidney following chronic exposure to various carcinogenic<br />

and non-carcinogenic <strong>es</strong>trogens. In: Li JJ, Nandi S, Li SA<br />

(eds) Hormonal Carcinogen<strong>es</strong>is. Springer-Verlag, New York, 1992;<br />

293-297.<br />

100. Liehr JG, Han X, Bhat HK. 32 P-postlabelling in studi<strong>es</strong> of hormonal<br />

carcinogen<strong>es</strong>is. In: Phillips DH, Castegnaro M, Bartsch H (eds) Postlabelling<br />

Methods for Detection of DNA Adducts. International Agency<br />

for R<strong>es</strong>earch on Cancer (IARC), Lyon, France, no. 1993; 124: 149-155.<br />

101. Ashburn SP, Han X, Liehr JG. Microsomal hydroxylation of 2and<br />

4-fluoro<strong><strong>es</strong>tradiol</strong> to catechol metabolit<strong>es</strong> and their conversion to<br />

methyl ethers: catechol <strong>es</strong>trogens as possible mediators of hormonal<br />

carcinogen<strong>es</strong>is. Mol Pharmacol 1993; 43: 534-541.<br />

102. Li SA, Li JJ. Metabolism of mox<strong>es</strong>trol in the hamster kidney:<br />

significance for <strong>es</strong>trogen carcinogen<strong>es</strong>is. In: Li JJ, Nandi S, Li SA<br />

(eds) Hormonal Carcinogen<strong>es</strong>is. Springer Verlag, New York, 1992;<br />

117-124.<br />

103. Paul SM, Axelrod J, Diliberto Jr J. Catechol <strong>es</strong>trogen-forming<br />

enzyme of brain: demonstration of a cytochrome P450 monooxygenase.<br />

Endocrinology 1977; 101: 1604-1610.<br />

104. Purdy RH, Moore Jr PH, Williams MC, Goldzieher JW, Paul<br />

SN. Relative rat<strong>es</strong> of 2- and 4-hydroxy<strong>es</strong>trogen synth<strong>es</strong>is are dependent<br />

on both substrate and tissue. FEBS Lett 1982; 138: 40-44.<br />

105. Roy D, Bui QD, Weisz J, Liehr JG. Comparison of assays for<br />

catechol <strong>es</strong>trogen synthase activity: product isolation vs. radioenzymatic<br />

catechol-O-methyltransferase-coupled procedur<strong>es</strong>. J Steroid Biochem<br />

1989; 33: 243-249.<br />

106. Roy D, Weisz J, Liehr JG. The O-methylation of 4-hydroxy<strong><strong>es</strong>tradiol</strong><br />

is inhibited by 2-hydroxy<strong><strong>es</strong>tradiol</strong>: implications for <strong>es</strong>trogeninduced<br />

carcinogen<strong>es</strong>is. Carcinogen<strong>es</strong>is 1990; 11: 459-462.<br />

107. Bui QD, Weisz J. Monooxygenase mediating catechol<strong>es</strong>trogen<br />

formation by rat anterior pituitary is an <strong>es</strong>trogen-4-hydroxylase. Endocrinology<br />

1988; 124: 1085-1087.<br />

108. Paria BC, Chakraborty C, Dey SK. Catechol <strong>es</strong>trogen formation<br />

in the mouse uterus and its role in implantation. Mol Cell Endocrinol<br />

1990; 69: 25-32.<br />

109. Weisz J, Bui QD, Roy D, Liehr JG. Elevated 4-hydroxylation<br />

of <strong><strong>es</strong>tradiol</strong> by hamster kidney microsom<strong>es</strong>: a potential pathway of<br />

metabolic activation of <strong>es</strong>trogens. Endocrinology 1992; 131: 655-661.<br />

110. Zhu BT, Roy D, Liehr JG. The carcinogenic activity of ethinyl<br />

<strong>es</strong>trogens is determined by both their hormonal characteristics and<br />

their conversion to catechol metaboliti<strong>es</strong>. Endocrinology 1993; 132:<br />

577-583.<br />

111. Zhu BT, Bui QD, Weisz J, Liehr JG. Conversion of <strong>es</strong>trone to<br />

2- and 4-hydroxy<strong>es</strong>trone by hamster kidney and liver microsom<strong>es</strong>:<br />

implications for the mechanism of <strong>es</strong>trogen-induced carcinogen<strong>es</strong>is.<br />

Endocrinology 1994; 135: 1772-1779.<br />

112. Zhu BT, Conney AH. F<strong>un</strong>ctional role of <strong>es</strong>trogen metabolism in<br />

target cells: review and perspectiv<strong>es</strong>. Carcinogen<strong>es</strong>is 1998; 19: 1-27.<br />

113. Hayashi N, Hasegawa K, Komine A, Tanaka Y, McLachlan<br />

JA, Barrett JC, Tsutsui T. Estrogen-induced cell transformation and<br />

DNA adduct formation in cultured Syrian hamster embryo cells. Mol<br />

Carcinog 1996; 16: 149-156.<br />

114. Li SA, Xue Y, Xie Q, Li CI, Li JJ. Serum and tissue levels of<br />

<strong><strong>es</strong>tradiol</strong> during <strong>es</strong>trogen-induced renal tumorigen<strong>es</strong>is in the Syrian<br />

hamster. J Steroid Biochem Mol Biol 1994; 48: 283-286.<br />

VOLUMEN 13 - NÚMERO 6 - DICIEMBRE 2000

Hooray! Your file is uploaded and ready to be published.

Saved successfully!

Ooh no, something went wrong!