¿El estradiol es un carcinógeno mutagénico genotóxico?
¿El estradiol es un carcinógeno mutagénico genotóxico?
¿El estradiol es un carcinógeno mutagénico genotóxico?
Create successful ePaper yourself
Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.
80. Ursin G, London S, Stanczyk FZ, Gentzschein E, Paganini-Hill<br />
A, Ross RK, Pike MC. A pilot study of urinary <strong>es</strong>trogen metabolit<strong>es</strong><br />
(16α-OHE 1 and 2-OHE 1) in postmenopausal women with and without<br />
breast cancer. Environ Health Perspect 1997; 105S: 601-605.<br />
81. Tsutsui T, Suzuki N, Fukuda S, Sato M, Maisumi H, McLachlan<br />
JA, Barrett JC. 17β-Estradiol-induced cell transformation and aneuploidy<br />
of Syrian hamster embryo cells in culture. Carcinogen<strong>es</strong>is<br />
1987; 8: 1715-1719.<br />
82. Barrett JC, Wong A, McLachlan JA. Diethylstilb<strong>es</strong>trol induc<strong>es</strong><br />
neoplastic transformation without measurable gene mutation at two<br />
loci. Science 1981; 212: 1402-1404.<br />
83. Barrett JC, Tsutsui T. Mechanisms of <strong>es</strong>trogen-associated carcinogen<strong>es</strong>is.<br />
In: Huff J, Boyd J, Barrett JC (eds) Cellular and Molecular<br />
Mechanisms of Hormonal Carcinogen<strong>es</strong>is: Environmental Influenc<strong>es</strong>.<br />
Wiley-Liss, New York, 1996; 105-112.<br />
84. Tsutsui T, Maizumi H, McLachlan JA, Barrett JC. Aneuploidy<br />
induction and cell transformation by diethylstilb<strong>es</strong>trol: a possible<br />
chromosomal mechanism in carcinogen<strong>es</strong>is. Cancer R<strong>es</strong> 1983; 43:<br />
3814-3821.<br />
85. Tsutsui T, Barrett JC. Neoplastic transformation of cultured<br />
mammalian cells by <strong>es</strong>trogens and <strong>es</strong>trogen-like chemicals. Environ<br />
Health Perspect 1997; 105: 619-324.<br />
86. Endo S, Metzler M, Hieber L. Nonrandom karyotypic chang<strong>es</strong><br />
in a spontaneously immortalized and tumorigenic Syrian hamster<br />
embryo cell line. Carcinogen<strong>es</strong>is 1994; 15: 2387-2390.<br />
87. Lengauer C, Kinzler KW, Vogelstein B. Genetic instabiliti<strong>es</strong> in<br />
human cancers. Nature 1998; 396: 643-649.<br />
88. Li JJ, Nandi S, Li SA. Hormon<strong>es</strong> and carcinogen<strong>es</strong>is: laboratory<br />
studi<strong>es</strong>. In: Becker KL (ed). Principl<strong>es</strong> and Practice of Endocrinology<br />
and Metabolism. J.B. Lippincott, New York, 1995; 1856-1861.<br />
89. Li JJ, Li SA. Estrogen carcinogen<strong>es</strong>is in the hamster kidney: a<br />
hormone-driven multi-step proc<strong>es</strong>s. In: Huff J, Boyd J, Barrett JC (eds)<br />
Cellular and Molecular Mechanisms of Hormonal Carcinogen<strong>es</strong>is:<br />
Environmental Influenc<strong>es</strong>. Wiley-Liss, Philadelphia, 1996; 255-267.<br />
90. Li JJ. Perspectiv<strong>es</strong> in hormonal carcinogen<strong>es</strong>is. Animal models<br />
to human disease. In: Huff J, Boyd J, Barrett JC (eds) Cellular and<br />
Molecular Mechanisms of Hormonal Carcinogen<strong>es</strong>is: Environmental<br />
Influenc<strong>es</strong>. Wiley-Liss, Philadelphia, 1996; 447-454.<br />
91. Hou X, Li JJ, CHen W, Li SA. Estrogen-induced proto-oncogene<br />
and suppr<strong>es</strong>sor gene expr<strong>es</strong>sion in the hamster kidney: significance<br />
for <strong>es</strong>trogen carcinogen<strong>es</strong>is. Cancer R<strong>es</strong> 1961; 56: 2616-2620.<br />
92. Li JJ. Sex hormon<strong>es</strong> and neoplastic transformation. In: Li JJ, Li<br />
SA, Gustafsson JA, Nandi S, Sekely LI (eds) Hormonal Carcinogen<strong>es</strong>is<br />
II. Springer-Verlag, New York, 1996; 280-282.<br />
93. Li JJ, González Z, Banerjeee S, Banerjee SK, Li SA. Estrogen<br />
carcinogen<strong>es</strong>is in the hamster kidney: role of cytotoxicity and cell proliferation.<br />
Environ Health Perspect 1993; 101 [Suppl 5]: 259-264.<br />
94. Li JJ, Li SA. Estrogen carcinogen<strong>es</strong>is in hamster tissu<strong>es</strong>: a critical<br />
review. Endocr Rev 1990; 11: 524-531.<br />
95. Li JJ, Hou X, Banerjee SK, Liao DZ, Maggouta F, Norris JS, Li<br />
SA. Overexpr<strong>es</strong>sion and amplification of c-myc in the Syrian hamster<br />
kidney during <strong>es</strong>trogen carcinogen<strong>es</strong>is: a probable critical role in neoplastic<br />
transformation. Cancer R<strong>es</strong> 1999; 59: 2340-2346.<br />
96. Li SA, Klicka JK, Li JJ. Estrogen 2-/4-hydroxylase activity,<br />
catechol <strong>es</strong>trogen formation and implications for <strong>es</strong>trogen carcinogen<strong>es</strong>is.<br />
Cancer R<strong>es</strong> 1985; 45: 181-185.<br />
97. Li SA, Klicka JK, Li JJ. Regulation of <strong>es</strong>trogen 2-/4-hydroxylase<br />
activity in hamster kidney by <strong>es</strong>trogens and androgens. Endocrinology<br />
1986; 119: 1810-1815.<br />
Acta<br />
Obstetricia<br />
et<br />
Gynecologica<br />
98. Li JJ, Purdy RH, Appelman EH, Klicka JK, Li SA. Catechol formation<br />
of fluoro- and bromo-substituted <strong><strong>es</strong>tradiol</strong> by hamster liver microsom<strong>es</strong>:<br />
evidence for dehalogenation. Mol Pharmacol 1985; 27: 559-565.<br />
99. DiAugustine RP, Walker M, Li SA, Li JJ. DNA adduct profil<strong>es</strong><br />
in hamster kidney following chronic exposure to various carcinogenic<br />
and non-carcinogenic <strong>es</strong>trogens. In: Li JJ, Nandi S, Li SA<br />
(eds) Hormonal Carcinogen<strong>es</strong>is. Springer-Verlag, New York, 1992;<br />
293-297.<br />
100. Liehr JG, Han X, Bhat HK. 32 P-postlabelling in studi<strong>es</strong> of hormonal<br />
carcinogen<strong>es</strong>is. In: Phillips DH, Castegnaro M, Bartsch H (eds) Postlabelling<br />
Methods for Detection of DNA Adducts. International Agency<br />
for R<strong>es</strong>earch on Cancer (IARC), Lyon, France, no. 1993; 124: 149-155.<br />
101. Ashburn SP, Han X, Liehr JG. Microsomal hydroxylation of 2and<br />
4-fluoro<strong><strong>es</strong>tradiol</strong> to catechol metabolit<strong>es</strong> and their conversion to<br />
methyl ethers: catechol <strong>es</strong>trogens as possible mediators of hormonal<br />
carcinogen<strong>es</strong>is. Mol Pharmacol 1993; 43: 534-541.<br />
102. Li SA, Li JJ. Metabolism of mox<strong>es</strong>trol in the hamster kidney:<br />
significance for <strong>es</strong>trogen carcinogen<strong>es</strong>is. In: Li JJ, Nandi S, Li SA<br />
(eds) Hormonal Carcinogen<strong>es</strong>is. Springer Verlag, New York, 1992;<br />
117-124.<br />
103. Paul SM, Axelrod J, Diliberto Jr J. Catechol <strong>es</strong>trogen-forming<br />
enzyme of brain: demonstration of a cytochrome P450 monooxygenase.<br />
Endocrinology 1977; 101: 1604-1610.<br />
104. Purdy RH, Moore Jr PH, Williams MC, Goldzieher JW, Paul<br />
SN. Relative rat<strong>es</strong> of 2- and 4-hydroxy<strong>es</strong>trogen synth<strong>es</strong>is are dependent<br />
on both substrate and tissue. FEBS Lett 1982; 138: 40-44.<br />
105. Roy D, Bui QD, Weisz J, Liehr JG. Comparison of assays for<br />
catechol <strong>es</strong>trogen synthase activity: product isolation vs. radioenzymatic<br />
catechol-O-methyltransferase-coupled procedur<strong>es</strong>. J Steroid Biochem<br />
1989; 33: 243-249.<br />
106. Roy D, Weisz J, Liehr JG. The O-methylation of 4-hydroxy<strong><strong>es</strong>tradiol</strong><br />
is inhibited by 2-hydroxy<strong><strong>es</strong>tradiol</strong>: implications for <strong>es</strong>trogeninduced<br />
carcinogen<strong>es</strong>is. Carcinogen<strong>es</strong>is 1990; 11: 459-462.<br />
107. Bui QD, Weisz J. Monooxygenase mediating catechol<strong>es</strong>trogen<br />
formation by rat anterior pituitary is an <strong>es</strong>trogen-4-hydroxylase. Endocrinology<br />
1988; 124: 1085-1087.<br />
108. Paria BC, Chakraborty C, Dey SK. Catechol <strong>es</strong>trogen formation<br />
in the mouse uterus and its role in implantation. Mol Cell Endocrinol<br />
1990; 69: 25-32.<br />
109. Weisz J, Bui QD, Roy D, Liehr JG. Elevated 4-hydroxylation<br />
of <strong><strong>es</strong>tradiol</strong> by hamster kidney microsom<strong>es</strong>: a potential pathway of<br />
metabolic activation of <strong>es</strong>trogens. Endocrinology 1992; 131: 655-661.<br />
110. Zhu BT, Roy D, Liehr JG. The carcinogenic activity of ethinyl<br />
<strong>es</strong>trogens is determined by both their hormonal characteristics and<br />
their conversion to catechol metaboliti<strong>es</strong>. Endocrinology 1993; 132:<br />
577-583.<br />
111. Zhu BT, Bui QD, Weisz J, Liehr JG. Conversion of <strong>es</strong>trone to<br />
2- and 4-hydroxy<strong>es</strong>trone by hamster kidney and liver microsom<strong>es</strong>:<br />
implications for the mechanism of <strong>es</strong>trogen-induced carcinogen<strong>es</strong>is.<br />
Endocrinology 1994; 135: 1772-1779.<br />
112. Zhu BT, Conney AH. F<strong>un</strong>ctional role of <strong>es</strong>trogen metabolism in<br />
target cells: review and perspectiv<strong>es</strong>. Carcinogen<strong>es</strong>is 1998; 19: 1-27.<br />
113. Hayashi N, Hasegawa K, Komine A, Tanaka Y, McLachlan<br />
JA, Barrett JC, Tsutsui T. Estrogen-induced cell transformation and<br />
DNA adduct formation in cultured Syrian hamster embryo cells. Mol<br />
Carcinog 1996; 16: 149-156.<br />
114. Li SA, Xue Y, Xie Q, Li CI, Li JJ. Serum and tissue levels of<br />
<strong><strong>es</strong>tradiol</strong> during <strong>es</strong>trogen-induced renal tumorigen<strong>es</strong>is in the Syrian<br />
hamster. J Steroid Biochem Mol Biol 1994; 48: 283-286.<br />
VOLUMEN 13 - NÚMERO 6 - DICIEMBRE 2000