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Enfermedades Inmunologicas Digestivas - Asociación de ...

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ANTI-ANTIGENO SOLUBLE HEPATICO/HIGADO PANCREAS<br />

ANTI-SLA/LP<br />

� Se encuentran en el 10-30% <strong>de</strong> los pacientes adultos con<br />

HAI tipo I , pero es mas frecuente en niños (50%)<br />

� En algunos pacientes es el único anticuerpo encontrado lo<br />

que postuló el origen <strong>de</strong>l tipo III <strong>de</strong> HAI , se encuentra<br />

frecuentemente en hepatitis critogenica .<br />

Manns, M, Gerken, G, Kyriatsoulis, A, et al. Characterization of a new subgroup of<br />

autoimmune chronic active hepatitis by autoantibodies against a soluble liver<br />

antigen. Lancet 1987.<br />

Wächter, B, Kyriatsoulis A, Lohse, AW, et al. Characterization of liver cytokeratin<br />

as a major target antigen of anti-SLA antibodies. J Hepatol 1990<br />

Ballot, E, Homberg, JC, Johanet, C. Antibodies to soluble liver antigen: An<br />

additional marker in type 1 auto-immune hepatitis. J Hepatol 2000.

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