Consenso Mexicano de Osteoporosis - AMMOM

Consenso Mexicano de Osteoporosisen ratas 93 y que promueven aumento de DMO, aunque elefecto sobre fracturas en humanos, no ha sido aclarado. 94,95Combinación de agentes terapéuticosExisten algunos estudios que analizan la eficacia de la combinaciónde estrógenos con bifosfonatos, 96-99 demostrandonotables incrementos de la DMO. Hallazgos semejantes sehan observado en la combinación de HPT con alendronato.100,101 Sin embargo, la combinación calcitonina con HPT oesteroides anabólicos no muestran ese efecto sinérgico. Elpapel de estas combinaciones aún requiere de estudios.FuturoEste documento presenta brevemente las opciones de diagnósticoy manejo de la osteoporosis. También nos presentaalgunos avances y su posible aplicación en un futuro cercanocontra este problema. Sin embargo, el futuro inmediatonos presenta el reto de cambiar las expectativas del riesgofuturo de osteoporosis y fracturas secundarias a ella, a unacreciente población susceptible. Depende en buena medidadel médico el que más pacientes potenciales se beneficiencon la prevención, detección oportuna y su tratamiento temprano(Cuadro 13).AgradecimientosMerck Sharp & Dohme de México brindó su apoyo financieroy logístico a la Asociación Mexicana de MetabolismoÓseo y Mineral (AMMOM) para la realización de este documento.Referencias1. Anónimo. Consensus Development Conference: Diagnosis, prophylaxisand treatment of osteoporosis. AM J Med 1993; 94:646-50.2. Lindsay R. The burden of osteoporosis: Costs. Am J Med 1995; 98 (Supp12ª): 9S-11S.3. Barret-Connor E. The economic and human cost of osteoporotic fractures.Am J Med 1995: 98 (Supp12):3S-8S.4. Cooper C, Atkinson EJ, Melton LJ III. Mortality following hip fracture.Facts Res Gerontol 1994; 7:91-109.6. Miller CW. Survival and ambulation following hip fracture. J. Bone JointSurg (Am) 1978; 60: 930-4.7. Jensen JS, Bagger J.Long-term social prognosis after hip fractures. ActaOrthop Scand 1982; 53:97-101.8. Magaziner J. 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