SMD PRESENTATION - longue vie et autonomie (HEGP)

DIU ONCOGERIATRIE Universités Paris 5 & 6 Année 2008
Guidelines for treatment of iron
overload in patients with MDS
Consensus meeting in Florence (MDS
Foundation)
• Ferritin>1000µg/ml
or 2 units/months for at least 1 year
• No erythroid response to primary therapy or
ineligible for primary therapy
• Survival more than 1 year
• Presence of compromised organ function related
to Iron overload
Hémochromatose
• Mesure de la Surcharge de fer
• Ponction biopsie hépatique difficilement faisable
• IRM hépatique bonne corrélation
• http://oernst.f5lvg.free.fr/liver/iron.html
• Corrélation entre le taux de la ferritine et le risque
de complication cardiaque (2500ng/ml)
• Le nombre de concentrés globulaires
Total body iron stores (mg/kg)
300
250
200
150
100
50
CoIHF et stock en fer de
l’organisme
0
0 5 10 15 20 25
LIC (mg/g dry weight)
Regression line and 95% confidence limits (upper and lower) are shown
LIC = liver iron content
• Twenty-five patients with
iron overload, cirrhosis,
and liver samples ≥1 mg
dry weight, were
assessed
• The results
demonstrated the linear
relationship between
total body iron stores
and LIC levels (r = 0.98,
p