AggiornAmenti in riAnimAzione e terApiA intensivA - Pacini Editore

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plasma superoxide dismutase activity and mortality
in patients with septic
M.O. Guerreiro
F. Petronilho
M. Andrades
L. Constantino
F.G. Mina
J.C. Moreira
F.D. Pizzol
C. Ritter
Laboratório de Fisiopatologia
Experimental (MOG, FP, LC,
FGM, FDP, CR), Universidade
do Extremo Sul Catarinense,
Criciúma, SC, Brazil;
Programa de Pós Graduação
em Ciências Biológicas
(FP, MA, JCFM), Bioquímica,
Universidade Federal do Rio
Grande do Sul; Programa
de Pós Graduação em
Ciências Médicas (MOG),
Universidade Federal do Rio
Grande do Sul, Porto Alegre,
RS, Brazil
bACkGROUnd: The aim of this study was to determine whether plasma
superoxide dismutase (SOD) activity, in comparison with other oxidative
parameters, is associated with mortality in humans with septic.
METhOdS: We conducted a prospective observational study including
96 patients with septic. Blood samples were collected immediately after
study inclusion and 24 hours after. We then determined plasma levels of
thiobarbituric acid reactive species, protein carbonyls, SOD, and catalase
activities.
RESULTS: Plasma carbonyls and SOD activity, but not plasma thiobarbituric
acid reactive species and catalase activity, were significantly higher in
non-survivors. SOD activity significantly correlated with Acute Physiology
and Chronic Health Evaluation II and Multiple Organ Dysfunction Score. In
addition, SOD activity presented similar area under the receiver operator
characteristic curve when compared with Acute Physiology and Chronic
Health Evaluation II to predict mortality. A diminution of 25% or more on
SOD activity between D1 and D2 was associated with a better outcome.
COnCLUSIOn: Our data provide some new information on the use of plasma
SOD activity as a biomarker in human sepsis.
j Trauma 2010;69(6):E102-6