TEV - profilassi e terapia - Facolta' di Medicina e Chirurgia - Chieti
TEV - profilassi e terapia - Facolta' di Medicina e Chirurgia - Chieti
TEV - profilassi e terapia - Facolta' di Medicina e Chirurgia - Chieti
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Grade<br />
1A<br />
1C+<br />
1B<br />
1C<br />
Current Approach to Grades of Recommendation<br />
Clarity of<br />
Risk/Benefit<br />
Clear<br />
Clear<br />
Clear<br />
Clear<br />
Methodological Strength<br />
of Supporting Evidence<br />
RCTs without<br />
important<br />
limitation<br />
No RCTs but<br />
strong RCT results<br />
can be<br />
unequivocally<br />
extrapolated, or<br />
overwhelming<br />
evidence from<br />
observational<br />
stu<strong>di</strong>es<br />
RCTs with<br />
important<br />
limitation<br />
(inconsistent<br />
results,<br />
methodological<br />
flaws)<br />
Observational<br />
stu<strong>di</strong>es<br />
Implications<br />
Strong recommendation; can apply to most patients in<br />
most circumstances without reservation<br />
Strong recommendation; can apply to most patients in<br />
most circumstances<br />
Strong recommendation; likely to apply to most<br />
patients<br />
Interme<strong>di</strong>ate<br />
Interme<strong>di</strong>ate-strength strength recommendation; may change<br />
when stronger evidence is available<br />
da Geerts WH, et al. CHEST 2008; 133:381S–453S
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