TEV - profilassi e terapia - Facolta' di Medicina e Chirurgia - Chieti
TEV - profilassi e terapia - Facolta' di Medicina e Chirurgia - Chieti
TEV - profilassi e terapia - Facolta' di Medicina e Chirurgia - Chieti
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Randomized comparison of enoxaparin with unfractionated heparin for the<br />
prevention of venous thromboembolism in me<strong>di</strong>cal patients with heart<br />
failure or severe respiratory <strong>di</strong>sease ( (PRINCE PRINCE Study)<br />
665 pts<br />
randomly<br />
assigned to<br />
receive<br />
Group A<br />
Group B<br />
VTE 8.4% with enoxaparin vs 10 10.4% with UFH (P= (P=0.015 015)<br />
enoxaparin<br />
40 mg o.d.<br />
UFH<br />
5.000 UI t.i.d.<br />
Fewer deaths, blee<strong>di</strong>ng and adverse events with enoxaparin (P= (P=0.044 044)<br />
Enoxaparin at least as effective as UFH in the prevention of<br />
thromboembolic events in HF or severe respiratory <strong>di</strong>sease <strong>di</strong>sease. Its<br />
beneficial safety prophile and once once-daily daily administration is advantageous<br />
for inpatient and outpatient use<br />
Kleber FX, et al. Am Heart J 2003;145:614
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