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Diagnose en classificatie van acute leukemieën - UZ Leuven

Diagnose en classificatie van acute leukemieën - UZ Leuven

Diagnose en classificatie van acute leukemieën - UZ Leuven

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AML M2 (FAB)<br />

Acute myeloblastische<br />

leukemie met maturatie<br />

• 30-89% blast<strong>en</strong> (op NEC)<br />

• Granulocytaire compon<strong>en</strong>t > 10% (op<br />

NEC)<br />

• Monocytaire compon<strong>en</strong>t ≤ 20% (op<br />

NEC) (ge<strong>en</strong> andere criteria <strong>van</strong> M4!)<br />

- anemie-trombop<strong>en</strong>ie-leucocytose (met<br />

soms normaal tot verhoogd<br />

neutrofiel<strong>en</strong>aantal)<br />

- frequ<strong>en</strong>t Auerse stav<strong>en</strong><br />

- abnormale myeloïde precursor<strong>en</strong><br />

(hypogranulatie, hyposegm<strong>en</strong>tatie,<br />

bizarre kernvorm<strong>en</strong>)<br />

- soms dysplasie in rode <strong>en</strong><br />

megakaryocytaire reeks<br />

Dana Van Kerkhov<strong>en</strong> <strong>en</strong> Caroline Brusselmans LAG

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