Diagnose en classificatie van acute leukemieÃ«n - UZ Leuven

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AML met t(8;21)(q22;q22) • AML: 5-12 %, AML M2: 30 % • typische morfologische kenmerken – heterogene blasten – maturatie in granulocyten (met dysplasie) • CD19-CD56 expressie • AML1-ETO fusiegen • goede prognose Dana Van Kerkhoven en Caroline Brusselmans LAG
WHO classificatie, AML 1. AML with recurrent cytogenetic translocations - AML with t(8;21) (q22;q22), AML1/ETO - Acute PML with t(15;17) (q22;q21), PML/RAR-alfa - Variant acute PML with t(v;17), v/RARalfa - AML with abnormal bone marrow eosinophils inv(16) (p13;q22) or t(16;16) (q13;q22), CBFbeta/MYH11 - AML with 11q23, MLL gen abnormalities 2. AML with multilineage dysplasia - With prior myelodysplastic syndrome - Without prior myelodysplastic syndrome 3. AML and myelodysplastic syndrome, therapy related - Alkylating agent related - Topoisomerase II inhibitor related - Other types 4. AML not otherwise categorized AML minimally differentiated AML without maturation AML with maturation Acute myelomonocytic leukemia Acute monocytic leukemia Acute erythroid leukemia Acute megakaryocytic leukemia Acute basophilic leukemia Acute panmyelosis with myelofibrosis FAB
Page 1 and 2:
Diagnose en classificatie van acute
Page 3 and 4:
Diagnose en classificatie van acute
Page 5 and 6:
Wat is een acute leukemie? leeftijd
Page 7 and 8:
Prevalentie: 20-30/100 000 (50% acu
Page 9 and 10:
Belang van correcte identificatie v
Page 11 and 12: Morfologie • Onderscheid leukemie
Page 13 and 14: Myeloblast • 15-20 mm Ø • kern
Page 15 and 16: Monoblast • 15-25 mm Ø • kern:
Page 17 and 18: Diagnose van acute leukemieën •
Page 19 and 20: Cytochemie Dana Van Kerkhoven en Ca
Page 21 and 22: Immuunfenotypering ⇨ bepalen anti
Page 23 and 24: Immunofenotypische classificatie va
Page 25 and 26: Immuunfenotypering en subclassifica
Page 27 and 28: Immuunfenotypering en subclassifica
Page 29 and 30: Cytogenetica (karyotypering) • Di
Page 31 and 32: Moleculaire diagnostiek ⇨ snelle
Page 33 and 34: Prognose en cytogenetica in ALL Gun
Page 35 and 36: Prognose AML respons op inductie -
Page 37 and 38: Classificatie: nut? • Kennis van
Page 39: FAB: • Acute leukemie: - Minimaal
Page 42 and 43: • AML M0: Myeloïde leukemie met
Page 44 and 45: AML M2 (FAB) Acute myeloblastische
Page 46 and 47: AML M3 variant (FAB) = Hypogranulai
Page 48 and 49: AML M4 Eo AML M4 met eosinofilie
Page 50 and 51: AML M5b (FAB) Acute monocytaire leu
Page 52 and 53: AML M7 (FAB) Acute megakaryoblastis
Page 54 and 55: ALL FAB-classificatie Dana Van Kerk
Page 56 and 57: ALL L2 (FAB) Blasten ALL L2: - grot
Page 58 and 59: FAB classificatie niet meer “klin
Page 60 and 61: WHO-classificatie • Berust op mor
Page 64 and 65: Promyelocyten leukemie met t(15;17)
Page 66 and 67: AML met inv(16)(p13;q22) or t(16;16
Page 68 and 69: AML met 11q23 abnormaliteiten • 5
Page 70 and 71: AML met multilineage dysplasie •
Page 72 and 73: Vgl FAB en WHO class.sys.bij AML FA
Page 78 and 79: Casus 1: morfologisch PB: 84% blast
Page 80 and 81: Casus 1:andere • Spiraal CT sched
Page 82: Casus 2: Dana Van Kerkhoven en Caro
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Diagnose en classificatie van acute leukemieÃ«n - UZ Leuven

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