Diagnose en classificatie van acute leukemieën - UZ Leuven
Diagnose en classificatie van acute leukemieën - UZ Leuven
Diagnose en classificatie van acute leukemieën - UZ Leuven
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WHO <strong>classificatie</strong>, AML<br />
1. AML with recurr<strong>en</strong>t cytog<strong>en</strong>etic<br />
translocations<br />
- AML with t(8;21) (q22;q22),<br />
AML1/ETO<br />
- Acute PML with t(15;17) (q22;q21),<br />
PML/RAR-alfa<br />
- Variant <strong>acute</strong> PML with t(v;17),<br />
v/RARalfa<br />
- AML with abnormal bone marrow<br />
eosinophils inv(16) (p13;q22) or<br />
t(16;16) (q13;q22), CBFbeta/MYH11<br />
- AML with 11q23, MLL g<strong>en</strong><br />
abnormalities<br />
2. AML with multilineage dysplasia<br />
- With prior myelodysplastic<br />
syndrome<br />
- Without prior myelodysplastic<br />
syndrome<br />
3. AML and myelodysplastic syndrome,<br />
therapy related<br />
- Alkylating ag<strong>en</strong>t related<br />
- Topoisomerase II inhibitor related<br />
- Other types<br />
4. AML not otherwise categorized<br />
AML minimally differ<strong>en</strong>tiated<br />
AML without maturation<br />
AML with maturation<br />
Acute myelomonocytic leukemia<br />
Acute monocytic leukemia<br />
Acute erythroid leukemia<br />
Acute megakaryocytic leukemia<br />
Acute basophilic leukemia<br />
Acute panmyelosis with myelofibrosis<br />
FAB
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