Karen Amaral Tavares Pinheiro - Universidade Católica de Pelotas

More documents

Recommendations

Info

104 Conclusions Clinicians should enquire postpartum women about their history of stressful life events, PPAD, and suicidality. This study shows the potential role of BDNF in the neurobiology of association of PPAD and suicidality. This may contribute in psychiatryclinical decisions. Significant outcomes: 1. The BDNF levels are significantly low only in those women with PPAD and suicidality. 2. There were no difference, in this sample, between the BDNF levels and the different types of PPAD episodes (depression, mania, mixed) when associated with suicidality. 3. Stressful life events on gestational period were associated with low levels of BDNF in postpartum. Limitations 1. The cross-sectional design, in which BDNF is measured at one time point, limits inferences about causality 2. Low statistical power unable us to make adequate generalizations to other disorders beyond PPAD in association with suicidality in this sample. 3. No specific biological measure of stress was used. Keywords: postpartum affective disorder, suicidality, serum brain-derived neurotrophic factor (BDNF)
105 Introduction The postpartum period is a time of increased risk of new-onset psychiatric illness for new mothers, and the most serious consequence of this risk is a corresponding high risk of infanticide and suicide in women presenting postpartum affective disorders 1 . Moreover, it has been proposed that the cumulative impact of several factors, including stressful life events (SLEs), may play a role in the incidence of postpartum affective disorders (PPADs) 2 . PPADs are an important public health concern, particularly when it involves suicide attempts 3 . Prevalence of high suicide risk have varied from 4% to more than 15% 4 . Indeed, we have demonstrated that postpartum women with depression have an increased risk of suicidality, which is a behavior or attitude that suggests suicidal ideation 3 . The neurochemical mechanisms involved in suicidality are complex, but the putative role of neurotrophins has consistently been considered. Reduced brain-derived neurotrophic factor (BDNF) expression has been implicated in the neurobiology of stress and affective disorders, which are contributory factors in suicidal behavior 2,5,6,7 . Moreover, lower BDNF expression in the blood samples of individuals with suicidal risk 8 ) and in the postmortem brain tissue of people who committed suicide support the belief that the brain modulatory functions exerted by this neurotrophin could be disrupted and could affect suicide behavior 9,10,11 . Overall, BDNF expression is often reduced in humans with neuropsychiatric disorders and in animal models of neuropsychiatric disorders 5,12,13 . Although this evidence suggests that BDNF might play an integrative role in the neurobiological basis of neuropsychiatric disorders, its involvement in PPADs has received little attention. The main objective of this work was to understand the neuropsychiatric and biological factors that contribute to the risk of suicidal behavior in postpartum period. Thus, we
Page 1 and 2:
1 UNIVERSIDADE CATÓLICA DE PELOTAS
Page 3 and 4:
3 Transtornos do humor no período
Page 5 and 6:
5 AGRADECIMENTOS Ao meu orientador
Page 7 and 8:
7 ÍNDICE INTRODUÇÃO GERAL ......
Page 9 and 10:
9 INTRODUÇÃO GERAL Diversas alter
Page 11 and 12:
11 PARTE I - PROJETO I. IDENTIFICA
Page 13 and 14:
13 nos casos em que o suicídio é
Page 15 and 16:
15 IX. Os problemas de sono em beb
Page 17 and 18:
17 oportunizando menos interações
Page 19 and 20:
19 risco de desordens psicopatológ
Page 21 and 22:
21 I V. MÉTODOS 4.1. Delineamento
Page 23 and 24:
23 identificar crianças com atraso
Page 25 and 26:
25 Um questionário com variáveis
Page 27 and 28:
27 4.5. Pessoal Envolvido A equipe
Page 29 and 30:
29 Trinta dias após o nascimento d
Page 31 and 32:
31 4.12. Cronograma Atividades 1 2
Page 33 and 34:
33 12.Glasser, D. Child abuse and n
Page 35 and 36:
35 33.Kapczinski F, Quevedo J. Tran
Page 37 and 38:
VI. ANEXOS 37
Page 66 and 67: ANEXO 6.2 EDINBURGH POSTNATAL SCALE
Page 68 and 69: 68 ( ) Sim, na maioria das vezes. (
Page 76 and 77: ANEXO 6.4 QUESTIONÁRIO DE CAPTAÇ
Page 78: ANEXO 6.5 QUESTIONÁRIO MÃE PÓS-P
Page 95: ANEXO 6.7 QUESTIONÁRIO SOBRE BEBÊ
Page 100 and 101: 100 Consentimento Livre e Esclareci
Page 102 and 103: 102 Encaminhamentos ESTUDO SOBRE SA
Page 106 and 107: 106 investigated whether serum BDNF
Page 108 and 109: 108 characteristics of the sample,
Page 110 and 111: 110 treatment and SLEs in pregnancy
Page 112 and 113: 112 comes from a variety of studies
Page 114 and 115: 114 11. PANDEY GN, REN X, RIZAVI HS
Page 116 and 117: 116
Page 118 and 119: 118 Figure Captions Figure 1 Serum
Page 120 and 121: 120 Artigo 2: Serum NGF, BDNF and I
Page 122 and 123: 122 INTRODUCTION Several studies ha
Page 124 and 125: 124 underwent prenatal follow-up, a
Page 126 and 127: 126 Statistical Package, version 9.
Page 128 and 129: 128 A correlation within the biomar
Page 130 and 131: 130 relationship and that when the
Page 132 and 133: 132 not provide an adequate means o
Page 134 and 135: 134 12.Trevarthen C, Aitken KJ. Inf
Page 136 and 137: 136 32.Cirulli F, Francia N, Berry
Page 138 and 139: 138 Table 1 Sample characteristics
Page 140 and 141: 140 Artigo 3: Chronicity and severi
Page 142 and 143: 142 1. Introduction Infant sleep pr
Page 144 and 145: 144 assumed level of significance o
Page 146 and 147: 146 The results of the present stud
Page 148 and 149: 148 Gregory, A. M., e O’Connor, T
Page 150 and 151: 150 PARTE III - CONSIDERAÇÕES FIN
Page 152 and 153: 152 níveis de BDNF podem estar ass
Page 154 and 155:
154 HIPÓTESE X - Os transtornos do
Page 156:
156 do humor no período pós-parto
show all

Karen Amaral Tavares Pinheiro - Universidade Católica de Pelotas

Create successful ePaper yourself

Delete template?

Save as template?