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İBH ve tedavisi - Prof. Dr. Sadettin Hülagü

İBH ve tedavisi - Prof. Dr. Sadettin Hülagü

İBH ve tedavisi - Prof. Dr. Sadettin Hülagü

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METHOTREXATE<br />

• FOLĠK ASĠT ANTAGONĠSTĠ,PURĠN METABOL. BLOKE EDER<br />

• AZT / 6 - MP TEDAVĠSĠNE CEVAP VERMEYEN <strong>ve</strong>ya YTE ‘ LERĠ<br />

NEDENĠYLE KULLANILAMAYAN DĠRENÇLĠ OLGULARDA...<br />

• 7.5 mg / hafta------------> 25 mg / hafta Ġ.M - P.O<br />

ETKĠSĠ 8 - 10 HAFTADA BAġLAR. Genelde 12.5 mg/gün üstünde<br />

dozlar uzun süre tavsiye edilmiyor.<br />

• % 75 REMĠSYON<br />

• TERATOJEN<br />

• DOZA BAĞLI KARACĠĞER FĠBROZĠSĠ ( KÜMÜLATĠF 1.5 GRAM)

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