İBH ve tedavisi - Prof. Dr. Sadettin Hülagü
İBH ve tedavisi - Prof. Dr. Sadettin Hülagü
İBH ve tedavisi - Prof. Dr. Sadettin Hülagü
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ĠBH- tedavi seçenekleri<br />
• Proinflammatory cytokine inhibitors<br />
– Anti-TNF monoclonal antikorları:infliximab,CD571,CDP870,adalimunab<br />
– Soluble TNF receptors: etanercept,onercept<br />
– Anti-IL-12 monoclonal antibody<br />
– Anti-IFN-gama monoclonal antibody :HuZAF<br />
• Anti-inflammatory cytokine mediators<br />
– IL-10,recombinant IL-10:rHuIL-10,exvivoIL-10 gene transfer to <strong>ve</strong>ctor<br />
• Adhesion molecule inhibitors<br />
– Anti-a4 integrin monoclonal antibody :natalizumab<br />
– Anti-a4β7 integrin monoclonal antibody :LDP-02<br />
– Anti-sense oligonucleotide to intercellular adhesion mol-1: Isis 2302<br />
• T –cell inhibitors<br />
– Cyclosporine A<br />
– Anti CD3 monoclonal antibody: visilizumab<br />
– Anti-CD25 monoclonal antibodies: daclizumab,basiliximab
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