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opretholdes, hvilket betinger en nedsat flux, der også tydeligt kan erkendes påFigur 13. Genfindingen var glimrende for alle fire grupper og således også fordette delstudie som helhed (Tabel 13). Den samlede effekt af manglendeafvaskning af en lettere beskadiget hud i forhold til afvasket intakt hud kan sespå den totale receptor recovery, hvor manglende afvaskning af en letterebeskadiget hud giver anledning til over 8 gange så stor mængde absorberetcaffein (Tabel 13).Tabel 13. Penetration data for Caffein. Resultaterne er angivet som middelværdier +SEM.IntactNon-washedDamagedNon-washedIntactWashedDamagedWashedN 14 14 12 12Maximal flux (ug/cm2*h) 1.80 ± 0.31 8.66 ± 1.22 A 1.01 ± 0.16 AB 5.72 ± 0.65Kp (um/h) 4.50 21.65 2.53 14.30Lag-time (h) 6.5 ± 0.4 5.9 ± 0.4 5.0 ± 0.3 A 4.8 ± 0.2Donor wash at 6 h (µg) 380.3 ± 3.9 B 259.0 ± 20.3Donor wash at 48 h (µg) 285.6 ± 12.8 94.2 ± 18.1 AB 1.8 ± 0.2 A 1.2 ± 0.2Donor recovery (µg) 285.6 ± 12.8 94.2 ± 18.1 AB 382.1 ± 4.0 AB 260.2 ± 20.4Epidermis deposition (µg) 7.1 ± 0.8 3.2 ± 0.8 AB 0.5 ± 0.1 A 0.5 ± 0.1Dermis deposition (µg) 12.3 ± 1.3 17.0 ± 2.5 B 1.8 ± 0.2 AB 6.5 ± 1.3Skin deposition (µg) 19.4 ± 1.4 20.3 ± 2.5 B 2.3 ± 0.3 AB 7.0 ± 1.4Skin deposition (% of dose) 4.6 ± 0.3 4.8 ± 0.6 B 0.5 ± 0.1 AB 1.7 ± 0.3Donor recovery (% of dose) 67.4 ± 3.0 22.2 ± 4.3 AB 90.1 ± 0.9 AB 61.4 ± 4.8Receptor recovery (% of dose) 24.0 ± 2.9 65.1 ± 4.8 AB 8.1 ± 0.9 AB 34.9 ± 4.1Overall recovery (% of dose) 95.9 ± 0.5 95.1 ± 0.9 98.7 ± 0.2 97.9 ± 0.5Skin penetration (µg/cm 2 )T = 0h 0 ± 0 0 ± 0 0 ± 0 0 ± 0T = 4h 0.6 ± 0.2 3.8 ± 1.0 A 0.6 ± 0.2 B 2.5 ± 0.4T = 6h 2.0 ± 0.5 11.7 ± 3.4 A 1.7 ± 0.4 B 8.7 ± 1.6T = 8h 4.1 ± 1.1 24.6 ± 6.3 A 3.2 ± 0.8 B 19.3 ± 3.0T = 10h 7.3 ± 1.7 40.0 ± 8.9 A 5.3 ± 1.1 B 31.8 ± 4.4T = 12h 10.9 ± 2.4 56.2 ± 10.5 A 7.3 ± 1.4 B 41.7 ± 5.4T = 24h 27.2 ± 4.3 111.9 ± 10.6 AB 13.4 ± 1.6 AB 64.6 ± 7.2T = 29h 31.9 ± 4.8 117.4 ± 10.3 AB 14.4 ± 1.7 AB 66.3 ± 7.6T = 48h 48.0 ± 5.9 136.2 ± 9.5 AB 16.1 ± 1.7 AB 69.8 ± 8.2A – Significantly different from group with intact skin, non-washed (p