The vagus nerve as a modulator of intestinal inflammation - TI Pharma

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Vagal activity enhances macrophage phagocytosis Figure 2. Nicotine reduces Zymosan-induced pro-inflammatory mediator expression in peritoneal macrophages. A) Cytokine production induced by Zymosan phagocytosis, with pretreatment of nicotine in the indicated concentrations. IL10 intra is intracellular IL10. B) TNF release induced by Zymosan after pre-incubation with nicotine (gray bars) and nAChR blockers α-Bungarotoxin (Bgt), Methyllycaconitine (MLA) or dihydro-β-erythroidine (DHβE) where indicated. Data shown are average +/- SEM of 3 independent experiments performed in triplicate. Asterisks indicate significant differences (*p
Chapter 5 Figure 3 Cholinergic agonists stimulate phagocytosis via nAChR α4β2. A) Left panel, nicotine increases phagocytosis (percentage of cells positive for Zymosan) dose-dependently. Right panel, nicotinic (10 -6 M) increase in phagocytosis is counteracted by cholinergic blocker DHβE and 2,2,6,6-Tetramethylpiperidin- 4-yl heptanoate hydrochloride (TMPH), but not by NAChR α7 blockers αBgt and MLA. Data shown are average +/- SEM of 3-5 independent experiments in triplicate, asterisks indicate significant differences (P
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The vagus nerve as a modulator ofin
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The vagus nerve as a modulator of i
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Promotiecommissie Promotores: Prof.
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Table of contents Chapter 1 Introdu
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Introduction and outline The aim of
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Introduction and outline Hence, the
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Introduction and outline 18. van de
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Chapter 2 ABSTRACT The cholinergic
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Chapter 2 neurotransmitter ACh with
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Chapter 2 THE VAGUS NERVE AND CHOLI
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Chapter 2 nicotine treatment impair
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Chapter 2 Figure 1. Hypothetical sc
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Chapter 2 unclear whether this hybr
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Chapter 2 reduction of NF-κB activ
Page 29 and 30: Chapter 2 CONCLUDING REMARKS The hy
Page 31 and 32: Chapter 2 34 17. The FO, Boeckxstae
Page 33 and 34: Chapter 2 55. Moser N, Mechawar N,
Page 35 and 36: Chapter 2 93. Shafique S, Dalsing M
Page 37 and 38: Chapter 3 ABSTRACT Acetylcholine re
Page 39 and 40: Chapter 3 by bowel manipulation 12
Page 41 and 42: Chapter 3 for preparation of whole
Page 43 and 44: Chapter 3 Figure 1. Nicotine attenu
Page 45 and 46: Chapter 3 Figure 2. Inhibition of m
Page 47 and 48: Chapter 3 macrophage cell lysates s
Page 49 and 50: Chapter 3 reports 2 . We next incub
Page 51 and 52: Chapter 3 Figure 5. Perioperative e
Page 53 and 54: Chapter 3 Figure 7. Stimulation of
Page 55 and 56: Chapter 3 Activation of the STAT3 c
Page 57 and 58: Chapter 3 REFERENCE LIST 60 1. Trac
Page 59 and 60: 4 CHAPTER Deciphering STAT3 signali
Page 61 and 62: INTRODUCTION Deciphering STAT3 sign
Page 63 and 64: Deciphering STAT3 signaling in chol
Page 69 and 70: DISCUSSION Deciphering STAT3 signal
Page 71 and 72: REFERENCES Deciphering STAT3 signal
Page 73 and 74: Chapter 5 ABSTRACT Background and A
Page 75 and 76: Chapter 5 METHODS Reagents and anti
Page 77 and 78: Chapter 5 described previously 6 .
Page 79: Chapter 5 Figure 1 Cholinergic agon
Page 83 and 84: Chapter 5 we analyzed whether nicot
Page 85 and 86: Chapter 5 Zymosan induced formation
Page 87 and 88: Chapter 5 marker CD11 c (Fig. 7E),
Page 89 and 90: Chapter 5 Our data demonstrate that
Page 91 and 92: Chapter 5 REFERENCE LIST 96 1. Boro
Page 93 and 94: Thesis E.P.M. van der Zanden The va
Page 95 and 96: Summary and conclusions The goal of
Page 97 and 98: Summary and conclusions whether the
Page 99 and 100: Summary and conclusions exposure co
Page 101 and 102: REFERENCE LIST Summary and conclusi
Page 103 and 104: Nederlandse samenvatting
Page 105 and 106: Chapter 7 van STAT3 in de ‘cholin
Page 107 and 108: Chapter 7 De bevinding dat nicotine
Page 109 and 110: Chapter 7 macrofagen aan te tonen (
Page 111 and 112: Chapter 7 18. Yu Z, Zhang W, Kone B
Page 113 and 114: Shizuo Akira Department of Host Def
Page 115 and 116: List of publications
Page 117 and 118: Dankwoord
Page 119 and 120: om de ene keer olijfolie te drinken
Page 121: Curriculum Vitae Curriculum Vitae E
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The vagus nerve as a modulator of intestinal inflammation - TI Pharma

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