Vagal activity enhances macrophage phagocytosis 18. Gold ES, Underhill DM, Morrissette NS, Guo J, McNiven MA, Aderem A. Dynamin 2 is required for phagocytosis in macrophages. J Exp Med 1999;190:1849-1856. 19. Kabbani N, Woll MP, Levenson R, Lindstrom JM, Changeux JP. Intracellular complexes <strong>of</strong> the beta2 subunit <strong>of</strong> the nicotinic acetylcholine receptor in brain identified by proteomics. Proc Natl Acad Sci U S A 2007;104:20570-20575. 20. Greenwood B, Mantle M. Mucin and protein rele<strong>as</strong>e in the rabbit jejunum: effects <strong>of</strong> bethanechol and vagal <strong>nerve</strong> stimulation. G<strong>as</strong>troenterology 1992;103:496-505. 21. Groot J, Bijlsma P, Van Kalkeren A, Kiliaan A, Saunders P, Perdue M. Stress-induced decre<strong>as</strong>e <strong>of</strong> the <strong>intestinal</strong> barrier function. <strong>The</strong> role <strong>of</strong> muscarinic receptor activation. Ann N Y Acad Sci 2000;915:237-246. 22. Gareau MG, Jury J, Perdue MH. Neonatal maternal separation <strong>of</strong> rat pups results in abnormal cholinergic regulation <strong>of</strong> epithelial permeability. Am J Physiol G<strong>as</strong>trointest Liver Physiol 2007;293:G198-G203. 23. Soderholm JD, Perdue MH. Stress and g<strong>as</strong>tro<strong>intestinal</strong> tract. II. Stress and <strong>intestinal</strong> barrier function. Am J Physiol G<strong>as</strong>trointest Liver Physiol 2001;280:G7-G13. 24. Matsunaga K, Klein TW, Friedman H, Yamamoto Y. Involvement <strong>of</strong> nicotinic acetylcholine receptors in suppression <strong>of</strong> antimicrobial activity and cytokine responses <strong>of</strong> alveolar macrophages to Legionella pneumophila infection by nicotine. J Immunol 2001;167:6518-6524. 25. Galvis G, Lips KS, Kummer W. Expression <strong>of</strong> nicotinic acetylcholine receptors on murine alveolar macrophages. J Mol Neurosci 2006;30:107-108. 26. Moser N, Mechawar N, Jones I, Gochberg-Sarver A, Orr-Urtreger A, Plomann M, Sal<strong>as</strong> R, Molles B, Marubio L, Roth U, M<strong>as</strong>kos U, Winzer-Serhan U, Bourgeois JP, Le Sourd AM, De Bi<strong>as</strong>i M, Schroder H, Lindstrom J, Maelicke A, Changeux JP, Wevers A. Evaluating the suitability <strong>of</strong> nicotinic acetylcholine receptor antibodies for standard immunodetection procedures. J Neurochem 2007;102:479-492. 27. Whiteaker P, Marks MJ, Christensen S, Dowell C, Collins AC, McIntosh JM. Synthesis and characterization <strong>of</strong> 125I-alpha-conotoxin ArIB[V11L;V16A], a selective alpha7 nicotinic acetylcholine receptor antagonist. J <strong>Pharma</strong>col Exp <strong>The</strong>r 2008;325:910-919. 28. Huynh KK, Grinstein S. Phagocytosis: dynamin’s dual role in phagosome biogenesis. Curr Biol 2008;18:R563-R565. 29. van Koppen CJ, Kaiser B. Regulation <strong>of</strong> muscarinic acetylcholine receptor signaling. <strong>Pharma</strong>col <strong>The</strong>r 2003;98:197-220. 30. Kumari S, Borroni V, Chaudhry A, Chanda B, M<strong>as</strong>sol R, Mayor S, Barrantes FJ. Nicotinic acetylcholine receptor is internalized via a Rac-dependent, dynamin-independent endocytic pathway. J Cell Biol 2008;181:1179-1193. 31. Savidge TC, Newman P, Pothoulakis C, Ruhl A, Neunlist M, Bourreille A, Hurst R, S<strong>of</strong>roniew MV. Enteric glia regulate <strong>intestinal</strong> barrier function and <strong>inflammation</strong> via rele<strong>as</strong>e <strong>of</strong> S-nitrosoglutathione. G<strong>as</strong>troenterology 2007;132:1344-1358. 32. Soderholm JD, Yates DA, Gareau MG, Yang PC, MacQueen G, Perdue MH. Neonatal maternal separation predisposes adult rats to colonic barrier dysfunction in response to mild stress. Am J Physiol G<strong>as</strong>trointest Liver Physiol 2002;283:G1257-G1263. 33. Derikx JP, van Waardenburg DA, Thuijls G, Willigers HM, Koenraads M, van Bijnen AA, Heineman E, Poeze M, Ambergen T, van Ooij A, van Rhijn LW, Buurman WA. New Insight in Loss <strong>of</strong> Gut Barrier during Major Non-Abdominal Surgery. PLoS ONE 2008;3:e3954. 97
<strong>The</strong>sis E.P.M. van der Zanden <strong>The</strong> <strong>vagus</strong> <strong>nerve</strong> <strong>as</strong> a <strong>modulator</strong> <strong>of</strong> <strong>intestinal</strong> <strong>inflammation</strong> � Chapter 6: Cholinergic agonists can interact with immuno<strong>modulator</strong>y actions <strong>of</strong> neuropeptides VIP and SP � Chapter 7: Effects <strong>of</strong> smoking on nicotinic AChR expression and susceptibility to cholinergic immunomodulation in human monocytes Under embargo until June 23 rd 2013