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ACME 2011 Proceedings of the 19 UK National Conference of the ...

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Pressure, P (mmHg)<br />

Flow Rate, Q (L/min)<br />

140<br />

120<br />

100<br />

80<br />

60<br />

30<br />

20<br />

10<br />

0<br />

-10<br />

Normal Aneurysm Diameter <strong>of</strong> 5cm Aneurysm Diameter <strong>of</strong> 10cm Aneurysm Diameter <strong>of</strong> 15cm<br />

Ascending Aorta<br />

Aorta Arc B<br />

Thoracic Aorta A<br />

Thoracic Aorta B<br />

Abdominal Aorta A<br />

Abdominal Aorta D<br />

Ascending Aorta<br />

Aorta Arc B<br />

Thoracic Aorta A<br />

Thoracic Aorta B<br />

Abdominal Aorta A<br />

Abdominal Aorta D<br />

Figure 2b: Simulations <strong>of</strong> normal and various aneurysm sizes for one cardiac cycle (0.8s) where <strong>the</strong> medical terms can be shown in [3].<br />

4 CONCLUSIONS AND FUTURE WORK<br />

A 1D model <strong>of</strong> <strong>the</strong> human arterial system using <strong>the</strong> LCG finite element method is presented for normal ‘at<br />

rest’ state, for aneurysm sizes <strong>of</strong> 5cm, 10cm and 15cm. It should be noted that <strong>the</strong> aim <strong>of</strong> this paper is to<br />

identify arterial waveforms in <strong>the</strong> presence <strong>of</strong> a TAA. The example above showed that wave reflections<br />

occur when <strong>the</strong>re is a sudden widening in an artery. Future work includes studying <strong>the</strong> influences <strong>of</strong><br />

different aneurysm and stenosis shapes.<br />

Acknowledgement<br />

This work is partially funded by Levelhulme Trust grant F/00391/R. The first author acknowledges <strong>the</strong><br />

financial support received from <strong>the</strong> College <strong>of</strong> Engineering.<br />

References<br />

[1] J.C. Lasheras. The biomechanics <strong>of</strong> arterial aneurysms. Annual Review <strong>of</strong> Fluid Mechanics, 39, 293-<br />

3<strong>19</strong>, 2007.<br />

[2] A. Swillens, L. Lanoye, J.D. Backer, N. Stergiopulos, P.R. Verdonck, F. Vermassen and P. Segers.<br />

Effect <strong>of</strong> an abdominal aortic aneurysm on wave reflection in <strong>the</strong> aorta. IEEE Transactions on<br />

Biomedical Engineering, 55(5), 1602-11, 2008.<br />

[3] K.S. Matthys, J. Alastruey, J. Peiro, A.W. Khir, P. Segers, P.R. Verdonck, K.H. Parker and S.J.<br />

Sherwin. Pulse wave propagation in a model human arterial network: assessment <strong>of</strong> 1-D numerical<br />

simulations against in vitro measurements. Journal <strong>of</strong> Biomechanics, 40(15), 3476-3486, 2007.<br />

[4] J.P. Mynard and P. Nithiarasu. A 1D arterial blood flow model incorporating ventricular pressure,<br />

aortic valve and regional coronary flow using <strong>the</strong> locally conservative Galerkin (LCG) method.<br />

Communications in Numerical Methods in Engineering, 24, 367-417, 2008.<br />

[5] C.G. Thomas and P. Nithiarasu. An element-wise, locally conservative Galerkin (LCG) method for<br />

solving diffusion and convection-diffusion problems. International Journal for Numerical Methods<br />

in Engineering, 73, 642-664, 2008.<br />

[6] C.G. Thomas, P. Nithiarasu and R. L. T. Bevan. The locally conservative Galerkin (LCG) method<br />

for solving <strong>the</strong> incompressible Navier-Stokes equations. International Journal for Numerical<br />

Methods in Engineering, 57, 1771-1792, 2008.<br />

[7] S.J. Sherwin, V. Franke and J. Peiro. One-dimensional modelling <strong>of</strong> a vascular network in spacenetwork<br />

variables. Journal <strong>of</strong> Engineering Ma<strong>the</strong>matics, 47(3), 217-250, 2003.<br />

32

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