Beckwith-Wiedemann syndrome Hypoglossal nerve injury ... - MDC

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Eltrombopag and Improved Hematopoiesis in Refractory Aplastic Anemia We conducted a phase 2 study involving patients with aplastic anemia that was refractory to immunosuppression to determine whether the oral thrombopoietin mimetic eltrombopag (Promacta) can improve blood counts. Twenty-five patients received eltrombopag at a dose of 50 mg, which could be increased, as needed, to a maximum dose of 150 mg daily, for a total of 12 weeks. Primary end points were clinically significant changes in blood counts or transfusion independence. Patients with a response continued to receive eltrombopag. The Venn diagrams show the numbers of patients with unilineage, bilineage, and trilineage hematologic responses. Patients with a response and their response pattern at 12 weeks are shown on the left. Patients who met the response criteria at the most recent follow-up assessment are shown on the right.
Treatment with eltrombopag was associated with multilineage clinical responses in some patients with refractory severe aplastic anemia.
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Beckwith-Wiedemann syndrome Hypoglossal nerve injury ... - MDC

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