The Oxford Thesaurus An A-Z Dictionary of Synonyms INTRO ...

plague, worry, fret, fluster, trouble, pick at or on, Colloq
needle, get under (someone's) skin, get in (someone's) hair,
hassle, peeve, get on (someone's) nerves, drive (someone) up the
wall, get (someone's) hackles up, get (someone's) back up, drive
(someone) crazy or mad, rub (someone) (up) the wrong way, Brit
get up (someone's) nose, US burn (someone) up: All these stupid
questions are beginning to irritate me.
9.8 island...
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island n. isle, islet, ait, cay, key; atoll; archipelago; Brit dialect
eyot, holm: There are actually about 1500 islands in the
Thousand Islands in the St Lawrence river.
isolate v. separate, segregate, sequester, cloister, detach, cut off,
send to Coventry, ostracize, maroon, exclude, shut out, bar,
debar, banish, deport, transport, exile, reject, eject, throw
out, expel, shun, spurn, avoid, ignore, snub; quarantine; Colloq
cut, give (someone) the cold shoulder: You cannot isolate a
child from the pressures of modern society.
isolated adj. 1 lone, solitary, single, singular, unique, anomalous,
separate, special, particular, individual, exceptional,
unrelated: In one isolated case they recommended a suspended
sentence. 2 alone, separated, segregated, secluded,
sequestered, cloistered, unconnected, detached, (set) apart,
removed, cut off, excluded; forlorn, lonely, hermitic(al),
eremitic(al), anchoretic(al), troglodytic(al), monastic: Away
from his friends and family, he felt totally isolated. After his
wife died, he led an isolated existence. 3 secluded, remote,
out-of-the-way, off the beaten track, unfrequented, lonely;
secret, hidden: For twenty years we lived in that isolated
shack in the wilderness.
issue n. 1 outflow, outgoing, exit, egress, issuance, emanation,
efflux, debouchment, emergence, outlet: The river's colour
changed abruptly at its point of issue into the sea. 2 outcome,
conclusion, consequence, culmination, result, end, effect,
consummation, event, climax, Colloq pay-off: Whatever the
issue, it has been a brave effort. 3 point, topic, subject,
matter, affair, problem, question: That is an issue you should