MEDICINAL CHEMISTRY

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2 (a) 2 (b) 2 (c) H 3CO 2C H 3CO 2C H 3CO 2C CH 3 CH 3 N H OCH 3 N C-C-CH(CH 3) 2 CH 3 (CH 2) 3 N CH 3 (CH 2) 2 OCH 3 Verapamil (10) N H OCH 3 OCH 3 NO 2 Nifedipine (12) NO 2 CO 2CH 3 CH 3 CO 2CH 2CH 3 CH 3 Nitrendipine (14) N H Cl CO 2C 2H 5 CH 2O(CH 2) 2NH 2 Amlodipine (16) H 3CO 2C CH 3 N H Cl Cl H 3C H 3C H 3C H 3COOC CO 2CH 2CH 3 CH 3 Felodipine (17) CHOOC S H N CH2 O H2C N CH3 Diltiazem (11) H N CH 3 N H OCH 3 H O-C-CH 3 CH 3 O NO 2 CH 3 Nimodipine (13) CH 3 COOCH 2CH 2NCH 2 NO 2 H 3C O H 3COC COOCH 2CH 2OCH 3 CH 3 Nicardipine (15) H N H CH 3 O COCH(CH 3) 2 N N O Isradipine (18)
2 (d) 4. H 3C H 3C HO CH-CH 2-O-CH 2-CH-CH 2-N OH N N N Bepridil (19) N N N N N N OH Dypyridamole (20) H 3CO H 3CO OH Papaverine (22) Chemistry: preparation of Dypyridamole: Synthesis of Dypyridamole (20) HO N HO OH N (23) OH N OH N N N OH PCl 5/POCl 3 N N N N N N Cl N N N N Cl N (24) N N HN N N OCH 3 OCH 3 N Cl N HN CH 2CH 2OH CH 2CH 2OH N N Dypyridamole (20) OH (25) OH OH O O Cyclandelate (21) Cl
Page 1 and 2: CONTENTS Antianginal Drugs Anticoag
Page 3: c) Dihydropyridine derivative: e.g.
Page 7 and 8: pentaerythritol, and is supplied di
Page 9 and 10: of' streptokinase, urokinase and ti
Page 11 and 12: Low-molecular-weight Heparins, B.P.
Page 13 and 14: OH COOCH 3 AC 2O Methyl salicylate
Page 15 and 16: Warfarin and other coumarin derivat
Page 17 and 18: Structure-activity Relationship All
Page 19 and 20: Mean Arterial Blood Pressure (MABP)
Page 21 and 22: Table-1 ---------------------------
Page 23 and 24: Ramipril Altace ( Hoechst-Marion) 2
Page 25 and 26: Official drugs: Prazosin Hydrochlor
Page 27 and 28: treatment of hypertension, the dosa
Page 29 and 30: NH ClCH 2CN NCH 2CN Perhydroazocine
Page 31 and 32: B (2). Angiotensin Receptor Antagon
Page 33 and 34: CH3COOC2H5 Diazoxide (90) Cl NH 2 S
Page 35 and 36: Structure-activity Relationships of
Page 37 and 38: N N R Acidic group (102) Acidic gro
Page 39 and 40: Structure-activity Relationships of
Page 41 and 42: HO HO HO HO H 3C CH 3 H Digitoxigen
Page 43 and 44: efractory periods. These are mainly
Page 45 and 46: Structure - Activity Relationship:
Page 47 and 48: Hydralazine is a direct relaxant of
Page 49 and 50: K4[Fe(CN) 6].3H2O + 6HNO3 H2[(NO)Fe
Page 51 and 52: conduction velocity, and decrease s
Page 53 and 54: Synthesis of Moricizine: (153) H N
Page 55 and 56:
Tocainide Hydrochloride (±)-2-Amin
Page 57 and 58:
influx through β-receptor blockade
Page 59 and 60:
Cl Cl CH2CH=CH2 N N N H Alinidine (
Page 61 and 62:
(iii) Intermediate density lipoprot
Page 63 and 64:
Structure-activity Relationship Mev
Page 65 and 66:
to the bile acids. Thus due to ente
Page 67 and 68:
moderate reduction in cholesterol l
Page 69 and 70:
(iii) Other types: (a) Insulin rece
Page 71 and 72:
non-crystalline insulin as far as o
Page 73 and 74:
for better drug in this series. Sub
Page 75 and 76:
Key to general structure X SO 2 NH
Page 77 and 78:
Official Drugs: Insulin, B.P. It is
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MEDICINAL CHEMISTRY

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