REVIEW OF LITERATURE

27
realized utilizing selective rhodium-carbenoid insertion into the aromatic
nucleus as a pivotal step.
Wang et al. (1994) described the structure of polyprenols from five
conifer needles. The reported that polyprenol acetates were produced by
extraction, isolation and purification processes from the needles of five
coniferous species, named Pinus massoniana, Pinus thunbergii, Pinus
elliottii, Cedrus deodara and Juniperus chinensis. By 1HNMR and
13CNMR structure of Polyprenols were identified as betulaprenol-type
from leaves of these species as well as Ginkgo biloba.
Chowdhry et al. (1997) described the evaluation of himachalol in
murine invasive aspergillosis by comparative in vivo and in vitro method.
They reported that Aspergilli produce important severe infection. In
immunocompromises patients the available antifungals often cover
difficulties of MICs and correlation in therapy. An effort was made to
compare in vitro techniques for testing of antifungals, viz
polynes,imidazoles,5-flurorocytosine, amorolfine, and screened a phyto
product-himachalol (a sesquiterpene alcohol) from Cedrus deodara
(Roxb.) Loud, against A. fumigatus, clinical isolates (24) by macrobroth
two fold seal dilution (TFSD), microbroth microtitre (MT) and disc
diffusion (DD) techniques using various broth/agar media at varying
periods of incubation. The best activity in terms of geometric mean (GM)
(GM.MIC < 0.39 micrograms ml-1) was obtained with SCZ in the broth
by both MT of TFSD technique followed by ECZ (GM.MIC 0.39