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Complete <strong>Proteomics</strong> Workflow Effective Analysis of Proteins 14 Sample Preparation Effective analysis of proteins requires a strategy for reduction of sample complexity using gels, chromatography, or affinity-based separations. A strategic <strong>Proteomics</strong> Alliance with GE Healthcare gives Thermo customers direct access to GE Healthcare technologies and support. You can call upon us to help solve your most challenging separations needs utilizing Ettan gels, CyDye reagents, DeCyder software, and AKTA and Ettan chromatography systems and supports. Sample preparation Protein Identification using MALDI The Finnigan vMALDI source for the Finnigan LTQ creates a powerful new system for high-throughput protein ID using MALDI-MS/MS capability to provide protein ID based on peptide structure, not just peptide MW. This allows rapid identification of proteins by effective analysis of protein digest mixtures. 2D gel electrophoresis Multidimensional liquid chromatography
Protein Identification using Electrospray The Finnigan LTQ is the ideal MS system for protein analysis. The sensitivity and rapid scanning of the LTQ are combined to provide the best possible protein coverage and PTM identification for both simple and complex samples. The Finnigan ProteomeX LTQ system provides an integrated, turnkey solution for most proteomics applications, including high throughput protein ID, phosphorylation site mapping, and MudPIT. Protein identification using mass spectrometry Where additional capability is required, the MDLC LTQ system delivers ultimate versatility and analytical performance. FT-MS The Finnigan LTQ FT Hybrid provides extraordinary mass accuracy and resolution for difficult challenges such as PTM characterization and complex sample analysis. Bioinformatics TurboSEQUEST, incorporated into BioWorks, is the most cited protein identification algorithm in the scien- tific literature, yielding highly sensitive and confident answers. Both false positive and false negative rates for incorrect protein identification have fallen dramatically, reducing the burden of manual, post-analysis data review. Where increased computational speed is required, the SEQUEST Cluster can apply the power of a supercomputer to the analysis of your data, scalable to the needs of your lab. Bioinformatics • Identification • Quantification • Characterization 15
Page 1 and 2: Solutions for Protein Mass Spectrom
Page 3 and 4: izing Proteomics Innovation you can
Page 5 and 6: Sheer Analytical Power Finnigan LTQ
Page 7 and 8: CCD image of protein digest with α
Page 9 and 10: Integrated Proteomics Workstation F
Page 11 and 12: Phosphorylation Site Mapping Identi
Page 13: SEQUEST Cluster SEQUEST searching s

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