APPENDICES - NIHR Health Technology Assessment Programme

DOI: 10.3310/hta14370 Health Technology Assessment 2010; Vol. 14: No. 37
One hundred and twenty-nine publications,
with study designs that did not meet the
inclusion criteria for the review, reported on
patients with head and neck cancer being treated
with PDT. Details are lacking for many of these
publications, so the categorisations may not be
reliable.
There are three studies that appear to be
comparative, although the precise design is not
clear for any of them. 1–3
Fifteen publications are described as trials but
without a comparator group (Phase I/II pilot
studies), with sample sizes ranging from 5 to
121. 4–18
Eighty-seven publications report case series; 19–105
eight have over 100 patients, 26–28,33,61,87,94,105 but not
all of these contain patients with only head and
neck cancer; some studies report multiple cancer
site series. Eleven publications report on case
series, with between 50 and 100 patients, and 56
report less than 50 patients. For 12 publications
it is not clear what the sample size is. 19,39,40,48,56,57,6
0,64,68,82,85,99 Many of these publications are by the
same authors and appear to be updated series of
patients, or duplicate reports published in different
journals. Therefore, these publications may double
count patients to a certain degree.
Nineteen publications report fewer than 10
patients, 106–124 seven of which are single case
reports. 108,110,112,115,120,121,124
A further five publications remain
uncategorised. 125–129
References
Observational comparative studies
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therapy for laryngeal cancer.] Otolaryngol Head Neck
Surg 1997;69:407–10.
2. Lofgren LA, Hallgren S, Nilsson E, Westerborn A,
Nilsson C, Reizenstein J. Photodynamic therapy for
recurrent nasopharyngeal cancer. Arch Otolaryngol
Head Neck Surg 1995;121:997–1002.
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Appendix 12
Head and neck cancer scoping
3. Smucler R, Vlk P. Combination of laser induced
interstitial thermotherapy and photodynamic
therapy in the treatment of neck cancer. Lasers Surg
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Experimental non-comparative studies
4. Biel MA. Photodynamic therapy as an adjuvant
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5. Buchanan RB, Carruth JA, McKenzie AL, Williams
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7. Carruth JA, McKenzie AL. Preliminary report of
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8. Carruth JAS, Barrett JM, Barnes DWH, Buchanan
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11. Grossweiner LI, Hill JH, Lobraico RV.
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12. Hopper C, Kubler A, Lewis H, Tan IB, Putnam
G. mTHPC-mediated photodynamic therapy for
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13. Lou PJ, Jager HR, Jones L, Theodossy T, Bown
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