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na" A .-+^'IS^Jswo 50269 0304 QZ10 B^Ne.êmplat. Engli^h-Rvasl- dlctIen.ry. 2nd ed. l.nd.n. 6 lund Nu.phr(r*r 1551. • avlii. 1111 P. 21 c^. 0 http://legacy.library.ucsf.edu/tid/hvk78d00/pdf 4V.yv..^:4:^+_.. . .i. '
1. Sue. Connet. r:arm. sr ta5-xw ctYra) tW1 50269 8305 1/i/l7ei -79 III ?fe2-79 • â^ "^•/J• S.P. H. R. WATSON, R. HEMS, D. G. ROWSELL,• and D. J. SPRING _ Wilkinson Match Research Division, Poyle Road, Cofnbrook, Buckinghamshire Presented at the Annual Scientific Meeting, Society ojCosmetic Chemists, 1-2 December 1977. New York The anoltng sensation of inenthol on the skin results frem a physiological action on the nerve endings. Stsueluee/activity analysis as used in pharmacology has allowed prediction and subscquent synthesie of a largc numberof compounds which have the cooling action of menthol. The compounds range I. chemical type, e.g. esrhoxaeddea to ureas to phosphlne oxides. Many are as eRective as menthol, and yet do not have the disadvamages associated with its volatility; they are no-dorous and remain longer on the skin. To be eRective the compounds need to penetnte the skin, and as expected, the degree of eooling aensatiou for an arca of The body correlates inversely with the thickness of the stratum eorneum. The range of cooling e8ects (e.g. subjects' descriptions, duratlon of effect) which has been noted, and the ingueoco of vehicles, is described. Some postulates relating to the ease of sldn penetratlon, and the physical parameters of the molecule are discussed. Futun: potential applications are briefly described.. 0^ 4 u U c^ 0 0 4 6 2 http://legacy.library.ucsf.edu/tid/hvk78d00/pdf
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Page 1076 and 1077:
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Page 1181 and 1182:
50269 86e1 NEW YORK--TOBACCO/TOBACC
Page 1183 and 1184:
50269 8683 AIR----^^ÔLLUTION--HEAL
Page 1185 and 1186:
'^ 50269 8685 New Yerk Acadgay_ofSc
Page 1187 and 1188:
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Page 1189 and 1190:
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50269 8693 ANNALS OF THE,REWM$ Ml§
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Page 1203 and 1204:
50269 8703 RA 776 We 1966 ANNALS OF
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50269 8739 • . .._..._ . _.__ _.
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.. . , __ . . . . . . I 50269 8743
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Page 1271 and 1272:
1 50269 0771 LNDORPHINS/HORMONES/PE
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50269 8773 TOBACCO--SMOKING--HEART,
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ANNALS OF THE NEW YORK ACADEMY OF S
Page 1277 and 1278:
50269 8777 UARNINC/LANGUACE ACQUISI
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50269 8779 DRUG ABUSE/ T16THADnYE(
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I 50269 8809 BOOi:S--BIBLIOGRAPIIY/
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Page 1345 and 1346:
50269 8845 _., Was HewYo.rk Times--
Page 1347 and 1348:
1 50269 8847 R8F SOCIAL SCLEN( Z .
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Page 1569 and 1570:
50269 9069 TORACCO INnUSTRY--CANr.;
Page 1571 and 1572:
REF. QD 151 Cm 1975 Nickel 50269 90
Page 1573 and 1574:
50269 9073 TP 966 Nickal Go G' 'd r
Page 1575 and 1576:
R!. 44i Hr .1n74 50269 9075 /TI:RAT
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50269 9081 RC 261 On 1979 - - - ^ A
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50269 9269 .^...__,.__ ^.._....,_ _
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50269 9271 TOBACCO--LHAD/ 72 VI Re-
Page 1773 and 1774:
TOBACCO--SWITZERLAND/CIGARETTES--TA
Page 1775 and 1776:
%a 50269 9275 . . . . . - IX Sv -76
Page 1777 and 1778:
50269 9277 SMOKINC AND IIEALTN/TOBA
Page 1779 and 1780:
Leve^.tha1, Hoaard A FIELU ERPERIME
Page 1781 and 1782:
50269 9281 LASER INFRARED SPECTROSC
Page 1783 and 1784:
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Page 1785 and 1786:
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Page 1787 and 1788:
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Page 1789 and 1790:
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Page 1791 and 1792:
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Page 1793 and 1794:
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Page 1795 and 1796:
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Page 1797 and 1798:
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Page 1799 and 1800:
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Page 1801 and 1802:
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Page 1803 and 1804:
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Page 1805 and 1806:
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Page 1807 and 1808:
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Page 1809 and 1810:
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Page 1811 and 1812:
50269 9311 TOBACCO--NICOTINIC ACID/
Page 1813 and 1814:
a ^ N RIP CO^PF.R/SILVFR/GOLD/7,INC
Page 1815 and 1816:
aeY QD 151 cm 1973 61GRL`NDET VON G
Page 1817 and 1818:
LCAD JTI Tf NI Ja/?7RC?N I llii% k'
Page 1819 and 1820:
.a 1^ 50269 9319 QD CRENISTRT. ANAL
Page 1821 and 1822:
QD 117 St 1978 AIR--POLLUTIOA--AHAL
Page 1823 and 1824:
ETHYLENE DICHLORIDE U. S. DEPARTRiE
Page 1825 and 1826:
1 50269 9325 TO%ICITYy-CHENICAL COM
Page 1827 and 1828:
AIR--POLLUTION--ANALYSIS/CHEMISTRY,
Page 1829 and 1830:
50269 9329 KlID1A1tDK--WEISDaOEN1I0
Page 1831 and 1832:
1. REPORT NO. ]. EPA-600/3-78-057 5
Page 1833 and 1834:
(0961) zt-o2 `zo^ N;orox nc'Vax oys
Page 1835 and 1836:
liti9er^'^"^fl°hY'CHRif'/.YF6R'û;
Page 1837 and 1838:
ALKALOIDS--TOBACCO SMOKE/CICAREITES
Page 1839 and 1840:
( TRANSLATION 50269 9339 Robashi, Y
Page 1841 and 1842:
TRANSLATION 50269 9341 RJR CLASS NO
Page 1843 and 1844:
,....._.:_ YRANSi.ATION ...- ^^ . 5
Page 1845 and 1846:
RJR CLASS TRA-VSI.ATIOV • Yano, E
Page 1847 and 1848:
; TOBACCO--CONSTITUENTS/ TOBACCO--S
Page 1849 and 1850:
TOSACCO--SMORE--ACIDS/TOHACCO--SILO
Page 1851 and 1852:
50269 9351 TOBACCO--QUALITY/TOBACCO
Page 1853 and 1854:
50269 9353 TR9NSLATION ----- -- - I
Page 1855 and 1856:
TOBACCO--PYRA7.INES/SOBACCO--ANALYT
Page 1857 and 1858:
.,. , 1 50269 9357 TOBACCO._--SMOKE
Page 1859 and 1860:
. . 50269 9359 . • .....-__... .
Page 1861 and 1862:
AMINO ACIDS--TOBACCO/ ^ ^ 50269 936
Page 1863 and 1864:
Tr The differentiation of tobacco s
Page 1865 and 1866:
50269 9365 - ' - . ^ . '`TOBACCO--S
Page 1867 and 1868:
50269 9367 RJR CLASS NO. P,L ?liLET
Page 1869 and 1870:
50269 9369 77 I1Re-19 S.P. 1. CHROM
Page 1871 and 1872:
I 77 II Re-79 JAPAN. J. GENEtIts Vo
Page 1873 and 1874:
77 11 Re-79 S.P. 50269 9373 MUTAGEN
Page 1875 and 1876:
( 50269 9375 77 Î Re-79 Vo6 81, N.
Page 1877 and 1878:
NITRITE4/ TRANSPLACENTAL ACTION OFO
Page 1879 and 1880:
50269 9379 TOBACCO--CELLS/TOBf,CCO-
Page 1881 and 1882:
50269 9381 TOBa.CCO--AGING/TOB4CCn-
Page 1883 and 1884:
50269 9383 Carbon-13 Nuclear Mugnet
Page 1885 and 1886:
1 50269 9385 R,•.r.u,l,(.,,mm..nL
Page 1887 and 1888:
50269 9387 . I ,fgrk. Biof. Chrm.,
Page 1889 and 1890:
Pf1LYtffiRS AND POLY11S1tI7.ATI0IQ-
Page 1891 and 1892:
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Page 1893 and 1894:
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Page 1899 and 1900:
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Page 1901 and 1902:
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Page 1903 and 1904:
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Page 1905 and 1906:
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Page 1907 and 1908:
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Page 1909 and 1910:
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Page 1911 and 1912:
t 50269 9411 76 1 Ma-80 MASSACHUSET
Page 1913 and 1914:
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Page 1915 and 1916:
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Page 1917 and 1918:
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Page 1919 and 1920:
. 50269 9419 TP 990 Si 0 4 il 0 i)
Page 1921 and 1922:
TP 156 II 0^1 (1 Q 1 I ( I :: I ii
Page 1923 and 1924:
TOBACCO--LAW--GERMANY/ TOBACCO--PES
Page 1925 and 1926:
li 4 50269 9425 --------------.-•
Page 1927 and 1928:
50269 9427 FIT7ISHF° AND COALI\GS/
Page 1929 and 1930:
50269 9429 QD ^ 400 A Fi ,31tACTICA
Page 1931 and 1932:
50269 9431 QC ^MCT2CtV;-k21^î30N t
Page 1933 and 1934:
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Page 1935 and 1936:
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Page 1937 and 1938:
50269 9437 CNROMATOCRAPHIC ANALYSIS
Page 1939 and 1940:
50269 9439 0 4:1 b i t G L i^• :^
Page 1941 and 1942:
50269 9441 ^ (p 519 K U^^ 0 0 n f
Page 1943 and 1944:
QH 211 G1 1980 MICROSCOPE AND MICRO
Page 1945 and 1946:
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Page 1947 and 1948:
i ^ / ourr „p, It:, 33V2JOflSOd I
Page 1949 and 1950:
50269 9449 0 4 3 0 n n 2 1 8 3 1 mr
Page 1951 and 1952:
_J10).^^ 50269 9451 XXI Pte-79 S: .
Page 1953 and 1954:
X-RAYS-SPECTROMF:TRY/ CO11PI1TERS--
Page 1955 and 1956:
May 1973 73 III Rel 74 50269 9455 S
Page 1957 and 1958:
QC 451 Me PROTEINS--STRUCTURE„PT.
Page 1959 and 1960:
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Page 1961 and 1962:
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Page 1963 and 1964:
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Page 1965 and 1966:
50269 9465 BUSINESS TRANSACTIONS/PR
Page 1967 and 1968:
50269 9467 SAM WITT'S OFFICE (RJR I
Page 1969 and 1970:
C^? (1 Pl !1 n ê^. ^_-_..-,.;....-
Page 1971 and 1972:
S.Pf `liow Not to Reduce Cigarette-
Page 1973 and 1974:
l' !7e-ozc •d ^,FT (0[6T) U U U U
Page 1975 and 1976:
50269 9475 RJR CLASS NO. PAHPhLRT 7
Page 1977 and 1978:
I FORECASTING/INTERNATIONAL RELATIO
Page 1979 and 1980:
50269 9079 C^ 4 n n n n/ S ^! () (
Page 1981 and 1982:
^ 50269 9481 IX Re2-79 S.P. Aviatio
Page 1983 and 1984:
50269 9463 Pwrepnd a.d Afctoe SRiIL
Page 1985 and 1986:
. ., 50269 9485 ALCOHOLISM/ In: THE
Page 1987 and 1988:
50269 9487 76 II Pr RODENTS IN DESE
Page 1989 and 1990:
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Page 1991 and 1992:
(! 25..:.._ 2240 G f; fi () n(1 2.
Page 1993 and 1994:
50269 9493 îena 0 ct !1 n n il 7 I
Page 1995 and 1996:
50269 9495 4eZ" e.e.' io G) G Y - 7
Page 1997 and 1998:
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Page 1999 and 2000:
50269 9499 PACKAGING--EUROPE/PACKAC
Page 2001 and 2002:
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Page 2003 and 2004:
TS 2240 50269 9503 avCN-PMTt00E D[
Page 2005 and 2006:
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Page 2007 and 2008:
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Page 2009 and 2010:
50269 9509 __._._ __...._^_ _.__ _.
Page 2011 and 2012:
50269 9511 0 4i.l Q !i rr.J G j ^)^
Page 2013 and 2014:
g tr•m1-1972 : trial compared a s
Page 2015 and 2016:
50269 9515 0 4 0 0 0 0 2 1 8 9 7 --
Page 2017 and 2018:
. 7^ , 80 11 Ey-81 50269 9517 Cogni
Page 2019 and 2020:
COMPUTEP.S--PROGRAMMING/ 2-27-79 76
Page 2021 and 2022:
..;^::.:.11IERN.OMETEi1S101DTifEF1:
Page 2023 and 2024:
, CASES--PROPERTiESPLIQUIDS/VAPOR P
Page 2025 and 2026:
50269 9525 79 X Re-81 ^ S.p. Herzfe
Page 2027 and 2028:
50269 9527 5 . 0 4.)n n na! y o 9 i
Page 2029 and 2030:
0 Afl C) i'? 0'/_ IÌ I' 1 ra;;+' .
Page 2031 and 2032:
' 50269 9531 Precioas Metals Stanfu
Page 2033 and 2034:
50269 9533 Ref. Q 123 Wa 0 4 tl 0 n
Page 2035 and 2036:
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Page 2037 and 2038:
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Page 2039 and 2040:
921 qCWe 1960 50269 9539 /PR6CIPITA
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Page 2045 and 2046:
50269 9545 77 II he / Jour. Physiol
Page 2047 and 2048:
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Page 2049 and 2050:
50269 9549 R.]R CLASS NO. TRA:iSLAT
Page 2051 and 2052:
Ti( GCfA --cl.s'^GMN a--/ yA / '4yy
Page 2053 and 2054:
50269 9553 INFORMATION CENTERS/COHI
Page 2055 and 2056:
50269 9555 0 !^ 0 0 0 0:: 1 9 3 7 F
Page 2057 and 2058:
50269 9557 TOBACCO--UIRECTORIBS/POL
Page 2059 and 2060:
50269 9559 REF '"PROPQ'T, Vo1.i70,N
Page 2061 and 2062:
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Page 2063 and 2064:
50269 9563 73 VII Bu TOBACCO--CURI
Page 2065 and 2066:
50269 9565 S/ c13 I`^SY."i4T;4^4PEi
Page 2067 and 2068:
50269 9567 F/EALF/fl /^1GfYHaUo^.Oi
Page 2069 and 2070:
[I TECHNICAL PAPERS DIVISION TECHNI
Page 2071 and 2072:
SMOKINC }1A8ITS--RELINOUISHINC/ /T0
Page 2073 and 2074:
- ^ ^ • 50269 9573 ZX RV8 S.P. Av
Page 2075 and 2076:
(qsrTEcg uS) (i :... L S 6 1 r 0 l)
Page 2077 and 2078:
50269 9577 :i Jahrsus L - - 3YY Die
Page 2079 and 2080:
^^' SMOKING HADITS--RELINQUISHING/
Page 2081 and 2082:
. 50269 9581 78 XI Adi-81 S.P. RJR
Page 2083 and 2084:
50269 9583 HIGH RISK/HEART --DISEAS
Page 2085 and 2086:
50269 9565 H 465 W1 1980 AG. BIOASS
Page 2087 and 2088:
SMOKING HABITS--RELINQUISHING/' TDB
Page 2089 and 2090:
. 50269 9509 . QP 458 w 0 4 n 0 n0
Page 2091 and 2092:
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Page 2093 and 2094:
50269 9593 /F00D--EVAL'JATION TECON
Page 2095 and 2096:
i., . •.T •_(' - $^9 E III. HaA
Page 2097 and 2098:
50269 9597 /ENF.ROY/ FOOD/ POPULATI
Page 2099 and 2100:
50269 9599 0 '1 0 0 n U2 1 9 8 1 Ni
Page 2101 and 2102:
50269 9601 HALLDCINOGENS/SMOKING AN
Page 2103 and 2104:
50269 9603 F?IDaYOCENESIS/PEfOS/TOK
Page 2105 and 2106:
50269 9605 ^.: • ^ t-- J ! PROGRE
Page 2107 and 2108:
50269 9607 WONEN/OCCUPATIONAL SAFET
Page 2109 and 2110:
50269 9609 0 4 0 n n o l 1 9 9 1. .
Page 2111 and 2112:
50269 9611 XI ToBZ 78 S.P ' . RJR C
Page 2113 and 2114:
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Page 2115 and 2116:
Preleverrment.•sur- piege• eA1
Page 2117 and 2118:
50269 9617 fl1TROCARAnNS, POT.YCYCI
Page 2119 and 2120:
50269 9619 S sas' XX HeF-C-M74 .iIC
Page 2121 and 2122:
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Page 2127 and 2128:
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Page 2139 and 2140:
^ 50269 9639 80 II Po The Peanut Jo
Page 2141 and 2142:
50269 9641 RJR CLASS NO. PAMPULET V
Page 2143 and 2144:
50269 9643 - »PRS'tTH1Efiliitl'fr'
Page 2145 and 2146:
50269 9645 Canadian Journal Plant S
Page 2147 and 2148:
1 50269 9647 DteB9 76 ^^hld4[[^CtC^
Page 2149 and 2150:
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INFANTS(PRE?fATURE)--CONGRESSF.S/:
Page 2165 and 2166:
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Page 2167 and 2168:
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Page 2171 and 2172:
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Page 2177 and 2178:
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Page 2185 and 2186:
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Page 2191 and 2192:
TOBACCO--ANATBSIS/ 1 50269 9691 74
Page 2193 and 2194:
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Page 2201 and 2202:
50269 9701 h8r W. Barbr.raChmtelors
Page 2203 and 2204:
CHP.OMATOCRAPHIC A\ALYSIS--TORACCO
Page 2205 and 2206:
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Page 2207 and 2208:
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a N ^ BIBLIOGRAPHY--pIARKETING RESF
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50269 9867 III Du2 77 S.P. Pressman
Page 2369 and 2370:
50269 9869 III DaZ S.P. 1. eno. N..
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50269 9877 0 q C) 0 n 0 2 2 1_, 9 !
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50269 9879 English) RJR CLASS NO. P
Page 2381 and 2382:
CIC.+RETTES--FILTERS--PRESSURE OROP
Page 2383 and 2384:
saC;TS ARD 11f.1'SURAS/l.Intn:u:;--
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P,Er TP 9 U1 1973 50269 9893 LIQUID
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50269 9895 0 ,atl (1 !t ni2?_ i 7 P
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50269 9897 '.^ /Composite Can and T
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. 21 Seplembcr 1974 S.-A. MEDIESE T
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!? ^? . r n .. ^ . I ApplieA Polymc
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50269 9943 STRUCTURE--DETERMINATION
Page 2445 and 2446:
50269 9945 WATER--TREATTfENT/WASTE
Page 2447 and 2448:
F00D--CARCINOGENS/- Lebensmittelche
Page 2449 and 2450:
50269 9949 23 M46 (/9yS, VI Re -81
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VI Re 9 -81 50269 9951 : S.PSpecial
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RCSPIRAI'ORY Ol:GA2lTF--DISEASCS/I:
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50269 9987 PREVENTIVE MEDICIBE/ALCO
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50269 9989 r PREVENTIVE MEDICINE/AL
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