« Maladie de Lyme » Borréliose

Term Clinical Case Definition Laboratory evidence essential Laboratory evidence supporting
Erythema
(chronicum)
migrans
Borrelial
lymphocytoma
Early
neuroborreliosis
Expanding red or bluish-red patch, often with
central clearing. Advancing edge typically
distinct, often intensely coloured, not markedly
elevated.
Rare, painless bluish-red nodule or plaque,
usually ear lobe, ear helix, nipple or scrotum
more frequent in children (especially on ear)
than in adults.
Painful meningo-radiculoneuritis with or without
facial palsy or other cranial neuritis (Garin-
Bujadoux-Bannwarth syndrome). In children
mostly meningitis, isolated unilateral
(sometimes bilateral) facial palsy, other cranial
neuritis.
Lyme carditis Acute onset of atrio-ventricular (II-III) conduction
disturbances, rhythm disturbances, sometimes
myocarditis or pancarditis.
Lyme arthritis Recurrent brief attacks of objective joint
swelling in one, or a few, large joints,
occasionally progressing to chronic arthritis.
Acrodermatitis
chronica
atrophicans
Chronic
neuroborreliosis
Long-standing red or bluish-red lesions, usually on
the extensor surfaces of extremities. Possible initial
doughy swelling. Lesions eventually become
atrophic. over bony prominences.
A very rare condition. Long-standing encephalitis,
encephalomyelitis, meningoencephalitis,
radiculomyelitis.
http://www.oeghmp.at/eucalb/diagnosis_case-definition-outline.html
None. Culture from skin biopsy.
*Significant change in levels of
specific antibodies or presence of
specific IgM.
*Significant change in levels of
specific antibodies or presence of
specific IgM.
+ Intrathecally produced specific
antibodies.
*Significant change in levels of specific
IgG antibodies.
Presence of specific IgG antibodies
(usually high levels)
Presence of specific IgG antibodies
(usually high levels)
Lymphocytic pleocytosis in CSF.
+ Intrathecally produced specific
antibodies.
Specific serum IgG.
Histology. Culture from skin biopsy.
Intrathecal total IgM and IgG.
Specific oligoclonal bands in CSF.
*Significant change in levels of
specific antibodies or presence of
specific IgM.
Culture from CSF.
Culture from endomyocardial biopsy.
Culture from synovial fluid and/or
tissue.
Histology, culture from skin biopsy.
Specific oligoclonal bands in CSF.
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