ANATOMY 1 Name of the Department: Department ... - Biomeedikum
ANATOMY 1 Name of the Department: Department ... - Biomeedikum
ANATOMY 1 Name of the Department: Department ... - Biomeedikum
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<strong>ANATOMY</strong><br />
<strong>Name</strong> <strong>of</strong> <strong>the</strong> <strong>Department</strong>: <strong>Department</strong> <strong>of</strong> Anatomy<br />
Head <strong>of</strong> <strong>the</strong> <strong>Department</strong>: Docent Helle Tapfer<br />
<strong>Name</strong> <strong>of</strong> Chair: Anatomy<br />
Head <strong>of</strong> <strong>the</strong> Chair: Docent Helle Tapfer<br />
Subject codes: ARAN.01.003; ARAN.01.008; ARAN.01.014;<br />
ARAN.01.015; ARAN.01.016; ARAN.01.017<br />
ARAN.01.018<br />
I. CONTENT OF THE TEACHING<br />
1. Describe shortly <strong>the</strong> main study and student evaluation methods applied at<br />
<strong>the</strong> department.<br />
The primary aim <strong>of</strong> anatomy is to give <strong>the</strong> medical students an entire picture <strong>of</strong><br />
a human body structure, to create three-dimension imagination <strong>of</strong> <strong>the</strong> organs,<br />
tissues and <strong>the</strong>ir relationships, to arouse <strong>the</strong> students’ interest in clinical problems.<br />
Anatomy as a basic science <strong>of</strong> all biomedical disciplines acknowledges<br />
<strong>the</strong> historical significance <strong>of</strong> anatomical disciplines and at <strong>the</strong> same time updates<br />
modern and future perspective in basic and applied anatomy.<br />
Systematic and topographic anatomy is taught in amount <strong>of</strong> 8,5 CP by means<br />
<strong>of</strong> lectures and practical works. In <strong>the</strong> first semester systematic anatomy<br />
takes 1 hour lecture and 6 hours practical works per week, in <strong>the</strong> second semester<br />
1 h lecture and 5 h practical works in <strong>the</strong> field <strong>of</strong> topographical anatomy<br />
- dissection course <strong>of</strong> corpses and neuroanatomy. Clinical anatomy is<br />
taught in <strong>the</strong> third academic year in amount 3 CP. (1CP - 40 hours). The individual<br />
control assessment methods are applied at <strong>the</strong> end <strong>of</strong> <strong>the</strong> organsystem<br />
(written and practical test) and at <strong>the</strong> end <strong>of</strong> <strong>the</strong> second semester - examination<br />
(written and practical test). Main objectives are:<br />
• to teach <strong>the</strong> structure <strong>of</strong> <strong>the</strong> human body on <strong>the</strong> level <strong>of</strong> macro- and microscopic<br />
anatomy in connection with <strong>the</strong> problems <strong>of</strong> regional and clinical<br />
anatomy;<br />
• to associate <strong>the</strong> teaching <strong>of</strong> anatomy with <strong>the</strong> newest achievements <strong>of</strong><br />
modern science;<br />
• to convey high moral and ethical convictions to <strong>the</strong> students in <strong>the</strong>ir attitude<br />
towards <strong>the</strong> teaching devices <strong>of</strong> anatomy;<br />
• to regard <strong>the</strong> course <strong>of</strong> dissection as <strong>the</strong> priority in teaching anatomy due to<br />
its being <strong>the</strong> most important means in mastering a three dimensional imagination<br />
<strong>of</strong> <strong>the</strong> body and practical skills;<br />
• to wake <strong>the</strong> students’ interest in future fields <strong>of</strong> medicine<br />
2. How have <strong>the</strong> aims and objectives described in <strong>the</strong> curriculum changed<br />
during <strong>the</strong> past five years?<br />
• Major changes undertaken in <strong>the</strong> new curricula, reduced <strong>the</strong> number <strong>of</strong><br />
teaching <strong>of</strong> systematic anatomy and laid <strong>the</strong> accent on <strong>the</strong> dissection<br />
course - <strong>the</strong> topographical anatomy and clinical aspects <strong>of</strong> teaching.<br />
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SECTION I: SELF-EVALUATION<br />
2<br />
• The teaching <strong>of</strong> systematic and topographic anatomy has been rearranged,<br />
transferred from semester 3 to semester 2. The number <strong>of</strong> lectures decreases<br />
30 %.<br />
• New optional subjects in <strong>the</strong> field <strong>of</strong> preparation, embryological-developmental<br />
anatomy and malformations in amount <strong>of</strong> 3CP are <strong>of</strong>fered.<br />
• Integration in anatomy and histology teaching is increased and <strong>the</strong> subjects<br />
end with <strong>the</strong> final joint examination in <strong>the</strong> subject block Anatomy and Histology<br />
3. Describe <strong>the</strong> strengths and weaknesses <strong>of</strong> <strong>the</strong> teaching in your department.<br />
Strengths<br />
• New Biomedical building with <strong>the</strong> modern equipment for teaching and scientific<br />
work.<br />
• Modern teaching process with all <strong>the</strong> multimedia possibilities as well as illustrated<br />
issues <strong>of</strong> anatomy in Estonian, high level <strong>of</strong> methodical work for<br />
Estonian and foreign students<br />
• The strength <strong>of</strong> teaching staff, whose members are highly valued because<br />
<strong>of</strong> <strong>the</strong>ir great length <strong>of</strong> service and experience in <strong>the</strong> field <strong>of</strong> anatomy: 3<br />
from 7 teachers have achieved a medical degree in anatomy, 2 <strong>of</strong> assistants<br />
are acquiring <strong>the</strong> degree <strong>of</strong> doctor- and have passed <strong>the</strong> examinations<br />
<strong>of</strong> doctorate.<br />
• The positive feedback from <strong>the</strong> students and participation in <strong>the</strong> practical<br />
works and lectures, great interest in anatomy and especially in <strong>the</strong> dissection<br />
course. Students evaluate highly <strong>the</strong> dissection course as <strong>the</strong> basic and<br />
main method <strong>of</strong> learning anatomy, mastering <strong>the</strong> practical skills. <strong>Department</strong><br />
<strong>of</strong> anatomy, having 300-year-old traditions in this field and being <strong>the</strong><br />
inheritor <strong>of</strong> <strong>the</strong> famous Rauber´s school <strong>of</strong> anatomy never gave up <strong>the</strong> dissection<br />
course.<br />
• The Rauber Museum <strong>of</strong> Human Body Exposition, established in 1895, has<br />
met generally wide appreciation and fame as well as <strong>of</strong>feres great help in<br />
studying <strong>of</strong> anatomy.<br />
• Research is carried out on <strong>the</strong> levels <strong>of</strong> macroanatomy as well as microanatomy<br />
and cellular level with integration <strong>of</strong> <strong>the</strong> clinical problems which<br />
supplements <strong>the</strong> teaching and motivates <strong>the</strong> students to choose <strong>the</strong> right<br />
priorities for future.<br />
• The teaching <strong>of</strong> anatomy is co-ordinated with <strong>the</strong> Centre <strong>of</strong> Anthropology.<br />
• New optional courses in <strong>the</strong> field <strong>of</strong> anatomy which <strong>of</strong>fer <strong>the</strong> possibility for<br />
additional preparation - joints, face, brain and development anatomy are introduced<br />
and turned out to be very popular.<br />
• For each lecture students receive materials in Estonian and English languages,<br />
with <strong>the</strong> illustrations and <strong>of</strong>ficial terminology (N.A.). These issues<br />
serve <strong>the</strong> students and clinicians throughout <strong>the</strong>ir working years.<br />
• Severe individual control has to be carried out after every organ-system<br />
study - by means <strong>of</strong> preliminary examination.
<strong>ANATOMY</strong><br />
Weaknesses<br />
• Limited time in <strong>the</strong> curriculum in relation to <strong>the</strong> extent <strong>of</strong> <strong>the</strong> material.<br />
• Some difficulties to integrate all <strong>the</strong> morphological disciplines histology,<br />
systematical anatomy and topographical anatomy in chronological order<br />
in a too short time (first year).<br />
4. Describe <strong>the</strong> innovations in your teaching.<br />
• Innovation <strong>of</strong> teaching process has become possible mainly with using all<br />
possibilities <strong>of</strong> multimedia.<br />
• The multimedia projectors for lectures and practical works.<br />
• Using <strong>the</strong> CD-ROM based interactive learning.<br />
• With <strong>the</strong> modern equipment in <strong>the</strong> new biomedicum building new health<br />
protecting equipment in <strong>the</strong> dissection process has been applied - preparation<br />
tables with ventilation, modern and more toxic solutions for cadavers<br />
embalm etc.<br />
• Collection <strong>of</strong> confidential data for donation has been created.<br />
5. <strong>Name</strong> <strong>the</strong> factors which most disturb teaching (excluding financial resources).<br />
Limited time in relation to <strong>the</strong> great extent <strong>of</strong> material to be studied. A freshman<br />
must learn <strong>the</strong> whole anatomical and histological terminology, thousand<br />
<strong>of</strong> new Latin words which will serve him through his entire medical study and<br />
future career.<br />
Freshmen need more emphasises on self-regulation <strong>of</strong> learning, <strong>the</strong> independent<br />
learning has to be organised more constructively, <strong>the</strong>y are not able to<br />
use textbooks in foreign languages.<br />
The textbooks <strong>of</strong> anatomy are not available for everyone in university library<br />
due to small editions.<br />
II. EVALUATION OF TEACHING<br />
6. How is <strong>the</strong> quality <strong>of</strong> teaching in your department evaluated? How are <strong>the</strong><br />
content and <strong>the</strong> modes <strong>of</strong> <strong>the</strong> teaching changed on <strong>the</strong> basis <strong>of</strong> <strong>the</strong> evaluation?<br />
The good atmosphere between <strong>the</strong> teachers and students has always been<br />
<strong>the</strong>re which allows good and direct feedback during and after <strong>the</strong> lectures and<br />
practical works. Anonymous questionnaire organised by <strong>the</strong> University, medical<br />
faculty and students’ level, evaluating <strong>the</strong> teaching and teachers.<br />
The change <strong>of</strong> <strong>the</strong> content and <strong>the</strong> modes <strong>of</strong> <strong>the</strong> teaching on <strong>the</strong> basis <strong>of</strong> <strong>the</strong><br />
evaluation.<br />
The evaluation has helped us immediately to react to <strong>the</strong> needs and improve<br />
<strong>the</strong> work. Arrange our teaching program on <strong>the</strong> level <strong>of</strong> our possibilities. During<br />
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SECTION I: SELF-EVALUATION<br />
4<br />
<strong>the</strong> last 5 years we have made great changes in order to modernise <strong>the</strong> content<br />
and modes <strong>of</strong> teaching. The main changes were increase <strong>the</strong> importance<br />
<strong>of</strong> practical works and clinical integration, critical comments and suggestions<br />
<strong>of</strong> students have been discussed in staff meetings and improvements have<br />
been considered.<br />
III. PEDAGOGICAL TRAINING OF STAFF<br />
7. How many <strong>of</strong> <strong>the</strong> teachers have received pedagogical training?<br />
All teachers in <strong>the</strong> department <strong>of</strong> anatomy have received practical and pedagogical<br />
training, senior staff has 20-38 years experience, <strong>the</strong> youngest - at<br />
least 10 years. The senior teachers and head <strong>of</strong> <strong>the</strong> department have received<br />
pedagogical training in advanced courses (1-2 months) in <strong>the</strong> departments <strong>of</strong><br />
anatomy <strong>of</strong> Moscow I and II Institute 1977, 1978; Moscow Institute <strong>of</strong> Stomatology<br />
1973; Moscow General Institute <strong>of</strong> Physical Culture 1981. The younger<br />
teachers have attended special pedagogical courses at <strong>the</strong> University <strong>of</strong> Tartu<br />
1999.<br />
8. Is <strong>the</strong>re a need for fur<strong>the</strong>r pedagogical training?<br />
The pedagogical training is necessary to keep up with <strong>the</strong> times, we suggest<br />
to <strong>the</strong> younger staff to attend regular courses <strong>of</strong> pedagogical training organised<br />
by University <strong>of</strong> Tartu.<br />
IV. TEACHING RESOURCES<br />
9. Is <strong>the</strong>re a need for rearrangement <strong>of</strong> <strong>the</strong> teaching resources in your department?<br />
If so, how should this be done?<br />
The teaching staff consists <strong>of</strong> 7 persons. The senior teaching staff includes 3<br />
assistant pr<strong>of</strong>essors who have a degree in medicine, obtained in <strong>the</strong> field <strong>of</strong><br />
anatomy with <strong>the</strong> length <strong>of</strong> service at <strong>the</strong> university 20-38 years.<br />
Three assistants have worked more than 10 years in <strong>the</strong> field <strong>of</strong> anatomy, 2<br />
<strong>of</strong> <strong>the</strong>m have passed <strong>the</strong> doctors exams and are now acquiring <strong>the</strong> Ph.D. degree.<br />
There are some problems with <strong>the</strong> future generation - <strong>the</strong> interest arose in<br />
<strong>the</strong> students to solve clinically oriented anatomical problems in <strong>the</strong> same time<br />
takes <strong>the</strong>m away from <strong>the</strong> <strong>the</strong>oretical departments to accomplish <strong>the</strong>ir mission<br />
in clinics, so <strong>the</strong> students are not motivated to return to <strong>the</strong> preclinic work.<br />
V. COORDINATION OF THE TEACHING<br />
10. How is <strong>the</strong> teaching co-ordinated with o<strong>the</strong>r departments? Indicate <strong>the</strong> departments<br />
that are closest to your department.<br />
Co-ordination <strong>of</strong> teaching is <strong>the</strong> main priority <strong>of</strong> <strong>the</strong> <strong>Department</strong> <strong>of</strong> Anatomy.
<strong>ANATOMY</strong><br />
To continue <strong>the</strong> integration <strong>of</strong> <strong>the</strong> subject <strong>of</strong> systematic and topographic anatomy<br />
with histology, anthropology and clinical anatomy in our department in<br />
time and content and between <strong>the</strong> o<strong>the</strong>r departments which are <strong>the</strong> closest<br />
subjects to morphology - physiology, pathological anatomy, phatological<br />
physiology, general and molecular biology and biochemistry.<br />
To develop co-operation with <strong>the</strong> University Clinics and foreign partners. This<br />
process has already begun in <strong>the</strong> field <strong>of</strong> traumatology and ortopaedics (Tartu<br />
University Clinic, Medical University Lübeck) and reproductive system (Turku<br />
University).<br />
VI. FUTURE PLANS<br />
11. Future plans to improve <strong>the</strong> teaching given by <strong>the</strong> department.<br />
• To renew and digitalise all <strong>the</strong> illustration materials for lectures and practical<br />
works, complement and improve slide collections.<br />
• Continuously adapt <strong>the</strong> teaching process to be in accordance with progress<br />
<strong>of</strong> sciences.<br />
• To enlarge <strong>the</strong> international medical students admittance to <strong>the</strong> <strong>Department</strong><br />
<strong>of</strong> Anatomy.<br />
• To continue and enlarge <strong>the</strong> amount <strong>of</strong> hours <strong>of</strong> dissection course and region<br />
<strong>of</strong> cadaver per student - as <strong>the</strong> basic study <strong>of</strong> anatomy.<br />
• To plan compose a new systematic anatomy book in <strong>the</strong> Estonian language<br />
according to <strong>the</strong> international standards.<br />
• To continue to publish brief concepts at <strong>the</strong> end <strong>of</strong> lectures on <strong>the</strong> problem.<br />
• To supplement <strong>the</strong> collection <strong>of</strong> <strong>the</strong> Rauber museum <strong>of</strong> anatomy.<br />
• To continue <strong>the</strong> retraining <strong>of</strong> laboratory staff as <strong>the</strong> main priority in research<br />
work.<br />
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SECTION I: SELF-EVALUATION<br />
<strong>Name</strong> <strong>of</strong> <strong>Department</strong>: <strong>Department</strong> <strong>of</strong> Anatomy<br />
Head <strong>of</strong> <strong>the</strong> <strong>Department</strong>: Docent Helle Tapfer<br />
<strong>Name</strong> <strong>of</strong> <strong>the</strong> Chair: Histology<br />
Head <strong>of</strong> <strong>the</strong> Chair: Docent Andres Arend<br />
Subject codes: ARAN.02.003; ARAN.02.008; ARAN.02.009;<br />
ARAN.02.010; ARAN.02.016; ARAN.02.014<br />
I. CONTENT OF THE TEACHING<br />
1. Describe shortly <strong>the</strong> main study and student evaluation methods applied at<br />
<strong>the</strong> department.<br />
Primary aims <strong>of</strong> <strong>the</strong> course are to lead <strong>the</strong> students to understand microscopic<br />
structure <strong>of</strong> cells, tissues, and organs and to correlate structure to function.<br />
Main objectives are:<br />
• to familiarise students with methods applied in histology;<br />
• to give experience <strong>of</strong> microscopy;<br />
• to explain <strong>the</strong> interpretation <strong>of</strong> tissue sections <strong>of</strong> histological slides;<br />
• to learn <strong>the</strong> cell structure;<br />
• to give <strong>the</strong> overview <strong>of</strong> basic structure <strong>of</strong> four main tissues: epi<strong>the</strong>lial tissue,<br />
connective/supportive tissue, muscular tissue, and nervous tissue;<br />
• to learn <strong>the</strong> stages <strong>of</strong> human embryonal development;<br />
• to learn <strong>the</strong> microscopic anatomy <strong>of</strong> all organ systems.<br />
Histology is taught by means <strong>of</strong> lectures and practical classes. In <strong>the</strong> first<br />
semester 1-hour lecture and 2 hours <strong>of</strong> practicals per week are held, in <strong>the</strong><br />
second semester 2 hours <strong>of</strong> lectures and 3 hours <strong>of</strong> practicals per week take<br />
place. During <strong>the</strong> practicals students have to master 107 histological slides.<br />
Histology is taught in amount <strong>of</strong> 5 credit points (CP), 2 CP as General Histology<br />
and Human Embryology in <strong>the</strong> subject block Medical Biology I and 3 CP<br />
as Histology in <strong>the</strong> subject block Anatomy and Histology. One credit point<br />
equals to 40 hours, thus <strong>the</strong> overall hours <strong>of</strong> <strong>the</strong> obligatory part <strong>of</strong> histology is<br />
200, as <strong>the</strong> number <strong>of</strong> classroom hours yielding one CP is 24 it makes 120<br />
hours <strong>of</strong> active classroom work in histology.<br />
Assessment methods are written tests throughout both semesters, preliminary<br />
examination after <strong>the</strong> first semester and <strong>the</strong> final examination at <strong>the</strong> end<br />
<strong>of</strong> <strong>the</strong> second semester.<br />
Additionally, Chair <strong>of</strong> Histology <strong>of</strong>fers elective courses: Immunohistology, 0,5<br />
CP; Histological techniques, 0,5 CP; Early stages <strong>of</strong> human development, 1<br />
CP; Morphology <strong>of</strong> oral cavity and teeth, 0,5 CP.<br />
2. How have <strong>the</strong> aims and objectives described in <strong>the</strong> curriculum changed<br />
during <strong>the</strong> past five years?<br />
6<br />
During <strong>the</strong> past five years new curriculum has been implemented resulting in<br />
significant changes in teaching <strong>of</strong> histology. Compulsory part <strong>of</strong> histology has
<strong>ANATOMY</strong><br />
been reduced from 6 CP to 5 CP. In <strong>the</strong> previous curriculum histology was<br />
taught as a separate subject during <strong>the</strong> second and third semester, in <strong>the</strong> new<br />
curriculum <strong>the</strong> teaching period has been shifted to <strong>the</strong> first and second semester<br />
and <strong>the</strong> subject is integrated into two subject blocks: general histology<br />
in Medical Biology I and special histology in Anatomy and Histology.<br />
Major changes undertaken in <strong>the</strong> new curriculum:<br />
• <strong>the</strong> traditional elementary course <strong>of</strong> general embryology has been given up;<br />
• teaching <strong>of</strong> human embryology is re-arranged in <strong>the</strong> form <strong>of</strong> elective subject<br />
(Early stages <strong>of</strong> human embryonal development);<br />
• cytology part is reorganized in co-ordinated manner with <strong>the</strong> subject Biology.<br />
Modern cell biology is a part <strong>of</strong> <strong>the</strong> subject Biology, while in histology<br />
necessary cytological details are studied toge<strong>the</strong>r with tissues and organs;<br />
• number <strong>of</strong> lectures has been decreased 25%;<br />
• format <strong>of</strong> <strong>the</strong> examination has been changed from <strong>the</strong> oral to written form<br />
and it forms a part <strong>of</strong> <strong>the</strong> final examination in <strong>the</strong> subject block Anatomy and<br />
Histology.<br />
• special histology (microscopic anatomy) is taught in more co-ordinated<br />
manner with anatomy;<br />
• number <strong>of</strong> new elective subjects has been introduced.<br />
3. Describe <strong>the</strong> strengths and weaknesses <strong>of</strong> <strong>the</strong> teaching in your department.<br />
Strengths<br />
Strengths <strong>of</strong> histology teaching involve:<br />
• modern teaching facilities combined with large demonstration collection <strong>of</strong><br />
histological slides collected throughout <strong>the</strong> decades;<br />
• <strong>the</strong> relatively large number <strong>of</strong> hours for students' practical works;<br />
• availability <strong>of</strong> histology textbooks in Estonian.<br />
Weaknesses<br />
Weaknesses in histology teaching concern:<br />
• histology teaching should be more related to elementary pathology, i.e.<br />
where appropriate normal histology must give more introductory examples<br />
<strong>of</strong> histopathology;<br />
• although teaching <strong>of</strong> special histology (microscopic anatomy) is coordinated<br />
with anatomy it should be organized in a more comprehensive<br />
manner;<br />
• limited number <strong>of</strong> teaching staff.<br />
4. Describe <strong>the</strong> innovations in your teaching.<br />
Innovations concern computerization <strong>of</strong> <strong>the</strong> teaching process in histology:<br />
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SECTION I: SELF-EVALUATION<br />
8<br />
• creation <strong>of</strong> computer-based original aid materials for practicals based on<br />
<strong>the</strong> same histological slides <strong>the</strong> students are studying;<br />
• use <strong>of</strong> multimedia projectors for practicals and for lectures;<br />
• original CD-ROM-based program for guiding students during individual work<br />
with histological slides is in process.<br />
5. <strong>Name</strong> <strong>the</strong> factors which most disturb teaching (excluding financial resources).<br />
• too large groups <strong>of</strong> students for practical works due to <strong>the</strong> shortage <strong>of</strong><br />
rooms for practicals in <strong>the</strong> new Biomedicum;<br />
• difficulties in planning practicals in <strong>the</strong> fall semester in <strong>the</strong> new Biomedicum<br />
as according to <strong>the</strong> new curriculum fall semester, compared to <strong>the</strong> spring<br />
semester, is significantly more filled up by different courses;<br />
• complications in finding suitable time for <strong>the</strong> electives as <strong>the</strong> students'<br />
timetable is booked up with compulsory subjects to at least 17.00;<br />
• although <strong>the</strong>re is a number <strong>of</strong> histology textbooks available in Estonian <strong>the</strong>y<br />
do not cover <strong>the</strong> whole subject area;<br />
• shortage <strong>of</strong> English textbooks at <strong>the</strong> University Library.<br />
II. EVALUATION OF TEACHING<br />
6. How is <strong>the</strong> quality <strong>of</strong> <strong>the</strong> teaching in your department evaluated? How are<br />
<strong>the</strong> content and <strong>the</strong> modes <strong>of</strong> <strong>the</strong> teaching changed on <strong>the</strong> basis <strong>of</strong> <strong>the</strong><br />
evaluation?<br />
A questionnaire-base student evaluation has been carried out at <strong>the</strong> end <strong>of</strong> <strong>the</strong><br />
lecture course organized at <strong>the</strong> Faculty level and by <strong>the</strong> Estonian Medical Students'<br />
Association. The given comments and suggestions are taken in consideration<br />
by <strong>the</strong> lecturers.<br />
The teaching staff has periodical meetings where current situation in teaching<br />
is analyzed; <strong>the</strong> most important meeting is after <strong>the</strong> final examination.<br />
Changes in <strong>the</strong> teaching process are made according to <strong>the</strong>se analyses and<br />
according to <strong>the</strong> students' feedback.<br />
III. PEDAGOGIC TRAINING OF STAFF<br />
7. How many <strong>of</strong> <strong>the</strong> teachers have received pedagogic training?<br />
All teachers have passed some short courses <strong>of</strong> university pedagogic.<br />
8. Is <strong>the</strong>re a need for fur<strong>the</strong>r pedagogic training?<br />
Additional pedagogical training is beneficial.
IV. TEACHING RESOURCES<br />
<strong>ANATOMY</strong><br />
9. Is <strong>the</strong>re a need for rearrangement <strong>of</strong> <strong>the</strong> teaching resources in your department?<br />
If so, how should this be done?<br />
Histology teaching staff has in moment 3,5 positions - two assistant pr<strong>of</strong>essors<br />
(docents), one full-time assistant and one half-time assistant. There is an urgent<br />
need to convert <strong>the</strong> existing half-time assistant position to <strong>the</strong> full time<br />
position.<br />
V. COORDINATION OF THE TEACHING<br />
10. How is <strong>the</strong> teaching co-ordinated with o<strong>the</strong>r departments? Indicate <strong>the</strong> departments<br />
that are closest to your department.<br />
Teaching <strong>of</strong> general histology and human embryology is co-ordinated with <strong>the</strong><br />
subject Biology (<strong>Department</strong> <strong>of</strong> General and Molecular Pathology, Chair <strong>of</strong><br />
Human Biology and Genetics) in <strong>the</strong> subject block Medical Biology I and special<br />
histology (microscopic anatomy) with <strong>the</strong> subject anatomy (<strong>Department</strong> <strong>of</strong><br />
Anatomy, Chair <strong>of</strong> Anatomy) in <strong>the</strong> subject block Anatomy and Histology.<br />
Closest to <strong>the</strong> Chair <strong>of</strong> Histology, beside <strong>the</strong> Chairs <strong>of</strong> Anatomy and Surgical<br />
Anatomy, are <strong>the</strong> <strong>Department</strong> <strong>of</strong> General and Molecular Pathology (Chair <strong>of</strong><br />
Human Biology and Genetics) and <strong>the</strong> <strong>Department</strong> <strong>of</strong> Pathological Anatomy<br />
and Forensic Medicine (Chair <strong>of</strong> Pathological Anatomy).<br />
VI. FUTURE PLANS<br />
11. Future plans to improve <strong>the</strong> teaching given by <strong>the</strong> department.<br />
Plans for <strong>the</strong> future changes aim:<br />
• to renew students' slide collections;<br />
• to complete <strong>the</strong> computer-based learning program for <strong>the</strong> students' individual<br />
work with histological slides;<br />
• to compose new histology textbooks in Estonian;<br />
• to fur<strong>the</strong>r integrate histology teaching with human biology and anatomy in<br />
terms <strong>of</strong> <strong>the</strong> time-schedule and <strong>the</strong> subjects' content.<br />
9
SECTION I: APPENDIXIES<br />
Anatomy: resource evaluation<br />
1. Study materials<br />
- How many study books are published in your institution during last five years? 4<br />
- Do you have separate room as library in your place? Yes No<br />
- Could students borrow study books from your institution? Yes No<br />
- Do you have on-line published study materials for students? Yes No<br />
- WWW address: ana@ut.ee<br />
- Does University library has enough modern books in your speciality?<br />
Completely enough Enough Scarcely Absolutely scarcely No<br />
2. Amount and size <strong>of</strong> study rooms<br />
- Rooms used by Your institution only: 5 rooms with area <strong>of</strong> 280 m 2<br />
- Rooms shared with ano<strong>the</strong>r institution: 2 rooms with area <strong>of</strong> 100 m 2<br />
- Do You have enough space for study process by Your opinion?<br />
Completely enough Enough Scarce Absolutely scarcely<br />
- How <strong>the</strong> scarce <strong>of</strong> space should be handled or changed?<br />
New building Change to smaller student groups Better logistics<br />
O<strong>the</strong>r way (describe shortly)<br />
3. Current situation <strong>of</strong> study rooms<br />
- There has been repairments in last years (except Biomedicum)<br />
- How are <strong>the</strong> study rooms lightened?<br />
Very good Good Some darkness Absolutely dark for study<br />
- Evaluation <strong>of</strong> general conditions: Very good Good Satisfactory Bad<br />
4. Your institution has<br />
a) 4 (how many?) auditorium(s) for workshops/seminars with 24 places, equipped with<br />
10<br />
Blackboard<br />
White board & markers<br />
Screen<br />
Overhead projector<br />
Data projector<br />
Slide projector<br />
b) 1 (how many?) laboratories for practicals with 24 places, equipped with<br />
Blackboard<br />
White board and markers<br />
Screen<br />
Overhead projector<br />
Data projector<br />
Slide projection kit<br />
TV/Video projection set<br />
Computer<br />
Internet connection<br />
TV/Video projection kit<br />
Computer<br />
Internet connection<br />
5. Working rooms for teaching staff and postgraduate students:<br />
- Number <strong>of</strong> teaching staff 13<br />
- Number <strong>of</strong> rooms for staff 8<br />
- Number <strong>of</strong> individual working places 14, among <strong>the</strong>m with computers 7<br />
- Number <strong>of</strong> postgraduate students is 2<br />
- How many individual working places <strong>the</strong>y have? 2<br />
- How many computers <strong>the</strong>y have? 1<br />
6. O<strong>the</strong>r comments on resource topic (max 250 letters): Practical works in anatomy take<br />
place in two dissection halls-area <strong>of</strong> 150 m2,with 8 preparationtables,removable,<br />
transportable equipment,hydraulic body lifters,special accessories-light sources,<br />
ventilation, refrigeration and conservation equipment
APPENDIX I-I<br />
Visits <strong>of</strong> <strong>the</strong> <strong>Department</strong> members to o<strong>the</strong>r institutions abroad during 1996-2000<br />
<strong>ANATOMY</strong><br />
Year Researcher/Lecturer Institution Country Purpose Duration<br />
1996 Andres Arend, assistant Umea University Sweden Training 2,5 weeks<br />
1996 Andres Arend, assistant Turu FIN Conference 1 week<br />
1996 Andres Arend, docent Kaunas Lithuania Conference 1 week<br />
1996 Helle Tapfer, docent Kaunas Lithuania Conference 1 week<br />
1996 Ivo Kolts, assistant Jena Germ. Conference 1 week<br />
1996 Ivo Kolts, assistant Med.University <strong>of</strong> Lübeck Germ. Training 2 months<br />
1996 Tambet Orrin, assistant Kaunas Lithuania Conference 1 week<br />
1997 Andres Arend, docent University <strong>of</strong> Turku FIN Research, Training 1 week<br />
1997 Andres Arend, docent University <strong>of</strong> Umea Sweden Research 1 week<br />
1997 Ennu Sepp, pr<strong>of</strong>. University <strong>of</strong> Turku FIN Research, Training 1 week<br />
1997 Helle Tapfer, docent University <strong>of</strong> Turku FIN Research, Training 1 week<br />
1997 Helle Tapfer, docent. Tampere FIN Conference 1 week<br />
1997 Ülo Hussar, pr<strong>of</strong> University <strong>of</strong> Turku FIN Research, Training 1 week<br />
1998 Hannes Tomusk, assistant University <strong>of</strong> Turku FIN Training 1 week<br />
1998 Ivo Kolts, docent Med. Univ. <strong>of</strong> Lübeck Germ. Research 1 week<br />
1998 Marina Aunapuu, labor. Med. Univ. <strong>of</strong> Lübeck Germ. Training 1,5 months<br />
1999 Aade Liigant. Docent Congress <strong>of</strong> IFAA,Rome ITA Conference, Training 1 week<br />
1999 Andres Arend, docent 4 Balt-NordicWorkshop NOR Conference 1 week<br />
1999 Andres Arend, docent University <strong>of</strong> Umea Sweden Research 1 week<br />
1999 Elle Põldoja, assistant Institute <strong>of</strong> Pathology Germ. Training 1 month<br />
1999 Hannes Tomusk, assistant University <strong>of</strong> Turku FIN Lectures 1 week<br />
1999 Helle Tapfer, docent Congress <strong>of</strong> IFAA,Rome ITA Conference, Training 1 week<br />
1999 Ivo Kolts, docent Congress <strong>of</strong> IFAA,Rome ITA Conference, Training 1 week<br />
1999 Ivo Kolts, docent Med. Univ. <strong>of</strong> Lübeck Germ. Research 2 months<br />
1999 Kersti Kokk, assistant NAFA FIN Conference 1 week<br />
1999 Kersti Kokk, assistant University <strong>of</strong> Turku FIN Research 1 month<br />
1999 Marina Aunapuu, labor. 4 Balt-NordicWorkshop NOR Conference 1 week<br />
1999 Marina Aunapuu, labor. University <strong>of</strong> Umea Sweden Conference 1 week<br />
1999 Marina Aunapuu, labor. University <strong>of</strong> Tampere FIN Research 2 weeks<br />
1999 Piret Hussar, assistant University <strong>of</strong> Gunma JAP Training 1 year<br />
2000 Aade Liigant. Docent Tripartite Meet.Cambridge U.K. Conference, Training 1 week<br />
2000 Andres Arend, docent University <strong>of</strong> Umea Sweden Research 1 week<br />
2000 Andres Arend, docent Congress <strong>of</strong> ISP FIN Conference 1 week<br />
2000 Eve Proovel, labor. Med. Univ. <strong>of</strong> Lübeck Germ. Training 1 week<br />
2000 Hannes Tomusk, assistant University <strong>of</strong> Turku FIN Lectures 1 week<br />
2000 Helle Tapfer, docent Tripartite Meet.Cambridge U.K. Conference, Training 1 week<br />
2000 Ivo Kolts, docent Tripartite Meet.Cambridge U.K. Conference, Training 1 week<br />
2000 Ivo Kolts, docent Med. Univ. <strong>of</strong> Lübeck Germ. Research 1 month<br />
2000 Kersti Kokk, assistant University <strong>of</strong> Turku FIN Research 1,5 months<br />
2000 Marina Aunapuu, labor. Tripartite Meet.Cambridge U.K. Conference 1 week<br />
2000 Marina Aunapuu, labor. Veterinary Conf Ukraine Conference 1 week<br />
11
SECTION I: APPENDIXES<br />
APPENDIX I-II<br />
Postgraduate students at <strong>the</strong> <strong>Department</strong> having studied abroad during 1996-2000<br />
Year <strong>Name</strong> Institution Contry Duration<br />
1999 Piret Hussar University <strong>of</strong> Gunma Japan 1 year<br />
1999 Kersti Kokk University <strong>of</strong> Turku FIN 4 week<br />
2000 Kersti Kokk University <strong>of</strong> Turku FIN 6 week<br />
APPENDIX I-III<br />
Co-operation with institutions from o<strong>the</strong>r countries and participation in international<br />
research projects during 1996-2000<br />
Contact person Institution Country Aim <strong>of</strong> <strong>the</strong> collaboration<br />
Assist. Kersti Kokk University <strong>of</strong> Turku FIN Research<br />
Assist. Hannes Tomusk University <strong>of</strong> Turku FIN Teaching<br />
Docent. Ivo Kolts Med. Univ. <strong>of</strong> Lübeck GER Research<br />
Docent Andres Arend University <strong>of</strong> Umea SWE Research<br />
APPENDIX I-IV<br />
Visiting lecturers at <strong>the</strong> <strong>Department</strong> during 1996-2000<br />
Visitor Institution Country Purpose <strong>of</strong> <strong>the</strong> Visit<br />
Pr<strong>of</strong>. Risto Santti University <strong>of</strong> Turku FIN Research<br />
Pr<strong>of</strong>. G. Selstam University <strong>of</strong> Umea SWE Research<br />
Pr<strong>of</strong>. Lüder Busch Med. Univ.<strong>of</strong> Lübeck GER Research<br />
Pr<strong>of</strong>. Ludwig Jonas University <strong>of</strong> Rostock GER Research<br />
Aileen Robertson WHO Denmark Conference<br />
Pr<strong>of</strong>. L.de K.Louw The University <strong>of</strong> <strong>the</strong> Free State Republic <strong>of</strong> South Africa Lecture<br />
APPENDIX I-V<br />
Scientific journals available at <strong>the</strong> <strong>Department</strong><br />
No <strong>Name</strong> <strong>of</strong> Journal Version<br />
1. Anatomical Record paper, online<br />
2. Anatomy and Embryology paper, online<br />
3. Cells Tissues Organs paper<br />
4. Journal <strong>of</strong> Anatomy paper<br />
5. Morfologiia paper<br />
12
APPENDIX I-VI<br />
Publications <strong>of</strong> <strong>the</strong> <strong>Department</strong> members during 1996-2000<br />
PAPERS IN INTERNATIONAL JOURNALS<br />
<strong>ANATOMY</strong><br />
1. Arend A, Zilmer M, Zilmer K. Dietary n-3 polyunsaturated fatty acids suppress reparative regeneration<br />
<strong>of</strong> <strong>the</strong> rat liver connective tissue . Natural Antioxidants and Food Quality in A<strong>the</strong>rosclerosis and<br />
Cancer Prevention. Cambridge, Royal Soc. <strong>of</strong> Chem, 1996, 60-66<br />
2. Pöllänen P, Cooper TG, Kokk K, Saari T, Setchell BP. Microvascular permeability to <strong>the</strong> F (ab’)2<br />
fragment <strong>of</strong> IgG in <strong>the</strong> male rat reproductive tract at puberty. Journal <strong>of</strong> Reproductive Immunology,<br />
1997, 32:221-240.<br />
3. Kaarma H, Salundi U, Thetl<strong>of</strong>f M. Body build structure <strong>of</strong> neonates. International Journal <strong>of</strong> Anthropology,<br />
1997, 12:21-28.<br />
4. Raidaru G, Ilomets T, Mõttus A, Maser M. Isolation <strong>of</strong> polysaccharides with antitumor activity from<br />
Sasa Kurilensis (Fr. et Sar. ). Experimental Oncology, 1997, 20, 4, 34-39.<br />
5. Orrin T, Roosaar P, Arend A. Sepp E, Hussar Ü. Functional histology <strong>of</strong> <strong>the</strong> gastric mucosa in rats<br />
after truncal vagotomy and pyloroplasty (in Russian). Morphologiia, 1998, 6,63-67.<br />
6. Hussar Ü, Milenin O, Tünder E, Sillakivi T, Pille A, Hussar P. Resconstructin <strong>of</strong> cervical oesophagus<br />
with free revascularized ileal transfer (experimental replacing). Vestnik Hirurgii, 1996, 155,<br />
5, 10-14.<br />
7. Tapfer H, Liigant A, Talvik R, Roosaar P, Hussar Ü, Mikelsaar M, Simovart EE. Pathomorphologic<br />
responses in experimental sepsis. Papers on Anthropology VII, Tartu,1997, 339-350<br />
8. Kolts I, Tomusk H, Rajavee E. Anatomy <strong>of</strong> Transverse Humeral Ligament. Papers on Anthropology<br />
VII, 1997, 191-197<br />
9. Peterson J, Tapfer H. On anthropological research at <strong>the</strong> institute <strong>of</strong> anatomy, University <strong>of</strong> Tartu,<br />
at <strong>the</strong> turn <strong>of</strong> <strong>the</strong> century. Papers on Anthropology VII, 1997, 291 - 300<br />
10. Orrin T, Roosaar P, Arend A, Sepp E. Changes in <strong>the</strong> number <strong>of</strong> positively stained parietal and<br />
chief cells in rat’s gastric fundic glands in <strong>the</strong> first months after truncal vagotomy. Papers on<br />
Anthropology VII, 1997, 275-283<br />
11. Talvik R, Liigant A, Tapfer H, Tamme K, Metsvaht T. Septic shock with disseminated micr<strong>of</strong>oci in<br />
multiple organs in man. Intensive Care Medicine, 1998, 24, 1, 73-77.<br />
12. Saluvere K, Peterson J, Saluste L, Koskel S. Systematisation <strong>of</strong> anthropometric data <strong>of</strong> 17 year-old<br />
schoolgirls from Tartu, Estonia. Anthropologische Anzeiger. Stuttgart: Schweizerbart, 1998, 56, 3,<br />
267-280.<br />
13. Milenin O, Hussar Ü, Tünder E. Morphometric parameters <strong>of</strong> ileac revascularized grafts <strong>of</strong> <strong>the</strong><br />
cervical portion <strong>of</strong> <strong>the</strong> oesophagus in dogs. Annales Chirurgiae et Gynaecologiae,1999,88,29-34.<br />
14. Kaasik A, Vassiljev V, Põldoja E, Kalda A, Zharkovsky A. Do nuclear condensation or fragmentation<br />
and DNA fragmentation reflect <strong>the</strong> mode <strong>of</strong> neuronal death? NeuroReport, Lippincott Williams&Wilkins,<br />
1999, 10, 9, 1937-1942<br />
15. Maiste E, Kaarma H, Thetl<strong>of</strong>f M. On <strong>the</strong> prospects <strong>of</strong> multivariate systematization <strong>of</strong> separate body<br />
measurements and indices <strong>of</strong> 15-year-old Estonian schoolgirls. Homo, 1999, 50,1,21-32<br />
16. Paajanen H. Haapasalo H, Kotilainen E, Aunapuu M, Kettunen J. Proliferation Potential <strong>of</strong> Human<br />
Lumbar Disc After Herniation. Journal <strong>of</strong> Spinal Disorders, 1999,12,1,57-60<br />
17. Tapfer H, Liigant A, Tamme K, Roosaar P, Põldoja E, Talvik R. Uniformity <strong>of</strong> pathomorphological<br />
changes in various organs in response to <strong>the</strong> experimental sepsis. Papers on Anthropology VIII,<br />
214-224<br />
18. Kaarma H, Tiit EM, Vaino K. Model <strong>of</strong> <strong>the</strong> newborn´s head. Papers on anthropology VIII, 1999, 49-<br />
59.<br />
19. Kaarma H, Volozh O, Kasmel J, Puss K. Applying patients´ height and weight data in epidemiological<br />
studies. Papers on Anthropology VIII, 1999, 60-64.<br />
20. Kasmel J. Foundation <strong>of</strong> <strong>the</strong> Anthropology Section <strong>of</strong> <strong>the</strong> Naturalists´ Society at <strong>the</strong> Estonian<br />
Academy <strong>of</strong> Sciences in 1939. Papers on anthropology VIII, 1999, 65-70.<br />
21. Lintsi M, Kaarma H, Saluste L. First experience <strong>of</strong> application <strong>of</strong> OMRON BF 300 Body Fat monitor<br />
to members <strong>of</strong> a Tartu sports club. Papers on Anthropology VIII, 1999, 95-102.<br />
22. Loolaid K, Loolaid V, Kaarma H, Saluste L. Dietary intake and body structure <strong>of</strong> girls from secondary<br />
schools <strong>of</strong> Tartu. Papers on Anthropology VIII, 1999, 103-108.<br />
23. Puss K. Predicion <strong>of</strong> <strong>the</strong> weight <strong>of</strong> <strong>the</strong> foetus and <strong>the</strong> newborn by ultra-sound measurements.<br />
Papers on Anthropology VIII, 1999, 167-175.<br />
24. Kaarma H, Tapfer H, Veldre G, Thetl<strong>of</strong>f M, Saluste L, Peterson J. Some principles to be considered<br />
when using young women’s anthropometric data. Biology <strong>of</strong> Sport, Warsaw, 1996,13,2,127-135<br />
13
SECTION I: APPENDIXES<br />
25. Kaarma H, Saluvere K, Peterson J, Veldre G, Saluste L, Koskel S. Multivariate anthropometric<br />
classification for secondary school girls. Acta Medica Baltica.1997 1: 33–35.<br />
26. Kaarma H, Raud J. Application <strong>of</strong> anthropometric data in obstetrics. Ginecologia Polska,1997, 58:<br />
37-43<br />
27. Peterson J, Saluvere K. Systematisation <strong>of</strong> anthropometric data <strong>of</strong> 18 year-old girls by a statistical<br />
model. Biology <strong>of</strong> Sport,1998, 15, 105 - 112.<br />
28. Arend A, Zilmer M, Zilmer K, Vihalemm T, Aunapuu M. Administration <strong>of</strong> alpha-Lipoic Acid<br />
Overcomes Detrimental Effects <strong>of</strong> n-3 PUFAs on Wound Healing in Rat. On-line Proceedings <strong>of</strong><br />
<strong>the</strong> 5 th Internet Congress on Biomedical Sciences’98 at McMaster University, Canada, 1998<br />
(available from URL: http://www.mcmaster.ca/inabis98/pharmtox/arend0843/index.html).<br />
29. Kaarma H, Kasmel J, Peterson J, Veldre G, Lintsi M, Saluste L, Loolaid K. Antropologitseski metod<br />
v meditsine. Biomeditsinskie i biosotsialnõje problemõ integratsionnoi antropologii. Võpusk 3, Tom<br />
1. Peterburg, 1999, 123-124.<br />
30. Arend A, Masso R, Masso M, Aunapuu M., Tomusk H. Lipid bodies as intracellular sites <strong>of</strong> prostaglandin<br />
formation in <strong>the</strong> cells <strong>of</strong> rat liver wound. Fourth Baltic-Nordic Workshop in Veterinary Anatomy.<br />
Proceedings. Oslo, 1999,11-13<br />
31. Aunapuu M, Suuroja T, Arend A, Tomusk H. Morphometric study <strong>of</strong> structural changes in <strong>the</strong> developing<br />
rat kidney. Fourth Baltic-Nordic Workshop in Veterinary Anatomy. Proceedings. Oslo,<br />
1999,17-20<br />
32. Selstam G, Masso R, Arend A, Masso M, Aunapuu M. Light and electron microscope immunocytochemical<br />
localization <strong>of</strong> cyclooxygenase 1 and 2 in corpus luteum <strong>of</strong> pregnant and pseudopregnant<br />
rat. Fourth Baltic-Nordic Workshop in Veterinary Anatomy. Proceedings. Oslo,1999,57-62<br />
33. Suuroja T, Aunapuu M, Arend A. Surface morphology <strong>of</strong> porcine and bovine oviduct during oestrus<br />
cycle. Fourth Baltic-Nordic Workshop in Veterinary Anatomy. Proceedings. Oslo,1999, 65-66<br />
34. Arend A, Zilmer M, Vihalemm T, Selstam G, Sepp E. Lopoic Acid Prevents Suppressions <strong>of</strong><br />
Connective Tissue Proliferation in <strong>the</strong> rat liver incluced byn - 3 PUFA-s A pilot study. Annals <strong>of</strong><br />
Nutrition and Metabolism (accepted: Juli 6, 2000)<br />
35. Orrin T, Roosaar P, Arend A, Sepp E, Hussar Ü. Long - term changer in <strong>the</strong> rat gastric mucosa<br />
after truncal vagotomy and pyloroplasty. Morphologia, Sankt - Peterburg, 1998, 114, 6, 63 - 67<br />
36. Veldre G, Jürimäe T, Kaarma H. Relationships between Anthropometric Parameters and Sexual<br />
Maturation in 12-to 15-Years-Old Estonian Girls Medicine and Sport Science Basel Karger AG,<br />
2001,44,71-84<br />
37. Kaarma H, Peterson J, Stamm R, Lintsi M, Kasmel J, Veldre G, Maiste E. Application <strong>of</strong> anthropometric<br />
data in medicine, health promotion and physical education. Russian Morphological<br />
Newsletter, Moscow, Ekspertiza, 2000, 359-360<br />
38. Lintsi M, Kaarma H, Saluste L, Kirss Ü, Vasar V. Comparisons <strong>of</strong> body fat assessement derived<br />
from bioelectrical impedance method and different anthropometric methods in 17-year-old boys.<br />
Papers on Anthropology IX, Tartu, 2000, 9:88-97<br />
39. Kaarma H, Stamm R, Veldre G, Kasmel J. Possibilities for classification <strong>of</strong> anthropometric data <strong>of</strong><br />
16-18-year-old Tartu schoolgirls considering <strong>the</strong>ir age and constitutional peculiarities. Papers on<br />
Anthropology, Tartu, 2000, 9:64-81<br />
40. Kasmel J. About <strong>the</strong> student days <strong>of</strong> <strong>the</strong> Latvian-American anatomist and anthropologist Pr<strong>of</strong>.<br />
Jekabs Primanis in Yurjev(Tartu) in 1911-1913. Papers on Anthropology, Tartu, 2000, 9:82-87<br />
41. Loko J, Lintsi M, Tiits M. Anthropometric pr<strong>of</strong>ile and strength development in bodybuilders at different<br />
ages. Papers on Anthropology, Tartu, 2000; 9, 106-116<br />
42. Kaarma H, Peterson J, Saluste L, Thetl<strong>of</strong>f M, Loolaid V. Centre for physical anthropology at <strong>the</strong><br />
University <strong>of</strong> Tartu (1993-1998). Acta Medico-historica Rigensia, Riga, 2000; 5 359-360<br />
43. Kasmel J, Kasmel T. Pr<strong>of</strong>essor Daniel Georg Balk - <strong>the</strong> first anthropology lecturer at <strong>the</strong> reopened<br />
University <strong>of</strong> Dorpat(Tartu) in 1802. Acta Medico-historica Rigensia. Riga, 2000; 5, 103-107<br />
44. Naaber P, Smidt I, Tamme K, Liigant A, Tapfer H, Mikelsaar M, Talvik R. Translocation <strong>of</strong> indigenous<br />
micr<strong>of</strong>lora in an experimental model <strong>of</strong> sepsis. J.Med. Microbiol. Vol 49 (2000), 431-439<br />
45. Tamme K, Liigant A, Tapfer H, Türi E, Mikelsaar M, Talvik R. Multiple organ dissemination <strong>of</strong> bacteria<br />
in experimental sepsis. Papers on Anthropology IX, 2000, 234-240<br />
46. Tamme K, Liigant A, Tapfer H, Talvik R. The value <strong>of</strong> blood cultures in diagnosing clinical sepsis J.<br />
International Med Research (accepted)<br />
47. Kolts I, Busch LC, Tomusk H, Arend A, Eller A, Merila M, Russlies M Anatomy <strong>of</strong> <strong>the</strong> coracohumeral<br />
and coracoglenoidal ligaments. Annals <strong>of</strong> Anatomt 2000; 182:563-566<br />
48. Hussar P, Märtson A, Hussar Ü, Haviko T. Posttraumatic endochondral ossification and bone (tibia)<br />
repair in rats. Ann.Chir. Gynaecol. (submitted).<br />
49. Hussar Ü, Hussar P, Märtson A, Haviko T. Posttraumatic bone repair in rats. Morfologija, St-<br />
Peterburg. (submitted).<br />
14
PAPERS IN ESTONIAN JOURNALS<br />
<strong>ANATOMY</strong><br />
1. Hussar Ü, Suuroja T, Lepp E, Tapfer H, Kolts I, Põldoja E, Liigant A., Tomusk H. Formaliini üldintoksikatsiooni<br />
ja lokaalse termilise kahjustuse järgne põrna regeneratsioon ning selle stimuleerimise<br />
võimalusi rotil. Eesti Arst, 1996, 6, 493-496<br />
2. Arend A, Masso R, Masso M. Indomethacin and prostaglandin E1 administration suppress labelled<br />
amino-acid incorporation into cell from rat regenerating connective tissue: evidence <strong>of</strong> labelled<br />
amino-acid incorporation into lipid bodies in cells from <strong>the</strong> wound area. The III Workshop <strong>of</strong> <strong>the</strong><br />
Veterinary Medicine Anatomists <strong>of</strong> <strong>the</strong> Baltic and Nordic Countries, Papers <strong>of</strong> <strong>the</strong> Conference.<br />
Tartu Estonian Agric. Univ1996, 7-14<br />
3. Orrin T, Arend A, Sepp E. Indometatsiin ja seedetrakti limaskesta kahjustus. Eesti Arst, 1996, 1,<br />
60-62<br />
4. Orrin T, Roosaar P, Arend A, Sepp E. Muutused mao pärisnäärmete rakulises koosseisus<br />
trunkaalse vagotoomia, indometatsiini ja tsimetidiini korral. Eesti Arst, 1996, 2, 103-105<br />
5. Roosaar P, Arend A, Orrin T, Sepp E. Prostaglandiin E2 , vagotoomia ja tsimetidiini toime<br />
6. indometatsiinist kahjustatud mao limaskestale (eksperimentaalne uurimus) . Eesti Arst, Tallinn,<br />
7. 1996,6, 486-489<br />
8. Aunapuu M, Suuroja T. Valge roti (WISTAR) neeru histoloogilisest struktuurist. Eesti<br />
9. Loomaarstlik Ringvaade, 1998, 6, 174 – 176.<br />
10. Loolaid K, Kaarma H, Loolaid V, Saluste L. 15-16 aastaste keskkoolitüdrukute kehaehitusest ja<br />
toitumisharjumustest. Eesti Antropomeetriaregistri Aastaraamat. Tartu, 1998,1,133-137.<br />
11. Varja J, Kaarma H. Kliinilis-antropomeetriliste andmete seos raseduse ja sünnituse kuluga. Eesti<br />
Antropomeetriaregistri Aastaraamat, 1998, 1, 16-22.<br />
12. Kaarma H, Peterson J, Kasmel J, Veldre G, Saluvere K, Saluste L. TÜ Füüsilise antropoloogia keskuse<br />
viieaastase töö kogemused ja edasised plaanid. Eesti Antropomeetriaregistri Aastaraamat.<br />
Tartu, 1998, 1, 23-25.<br />
13. Lintsi M, Liivamägi J, Aluoja A, Saluste L, Koskel S. Esialgseid tähelepanekuid Tartu gümnaasiumide<br />
viimase klassi noormeeste temperamendist ja selle variantidest. Eesti Antropomeetriaregistri<br />
Aastaraamat. Tartu, 1998, 1, 57-65.<br />
14. Peterson J, Liivamägi J, Saluste L, Koskel S. Kehaehitus ja temperament. Eesti Antropomeetriaregistri<br />
Aastaraamat. Tartu, 1998,1,71-77.<br />
15. Kaarma H, Peterson J, Kasmel J, Veldre G, Saluvere K, Saluste L, Loolaid K. Naise kehastruktuuri<br />
seaduspärasused ja nende kasutamisvõimalused terviseedenduses ja ravitöös. Eesti Arst, 1998,<br />
5, 420-422.<br />
16. Kaarma H, Voloz O, Puss K, Kasmel J, Solodkaja E, Abina J, Kamp R, Goldsteine G.<br />
17. Mõningate verelipiidide näitajate seos kehaehitusega. Eesti Arst, 1999, 5, 388-390.<br />
18. Kaarma H. Patsientide toitumisalane nõustamine. Eesti Arstide Liidu Teataja, 1999, 11, 10-11.<br />
19. Rebase K, Kaalep H, Espe V, Lintsi M, Kaarma H, Lemberg H, Nurmekivi A, Hussar P. Eesti kergejõustiku<br />
meistrivõistlustel osalenud mees- ja naissportlaste keha rasvasisaldusest. Spordipedagoogika<br />
Instituudi teadus- ja õppemetoodiliste tööde kogumik VII, Tartu, 1999, 214-230.<br />
20. Vaino K, Kaarma H, Tiit EM. Estimation <strong>of</strong> risc factors in connection with <strong>the</strong> shape and volume <strong>of</strong><br />
<strong>the</strong> newborns´s head. Folia Baeriana VII, Tartu, 1999, 77-80.<br />
21. Kasmel J. Loodusuurijate Seltsi antropoloogiasektsiooni asutamisest 1939. Aastal. Eesti Antropomeetriaregistri<br />
aastaraamat, 1999, 12-16.<br />
22. Lintsi M, Kaarma H, Saluste L. Tartu linna eesti noormeeste-abiturientide antropomeetriliste parameetrite<br />
prognoosimisest II. Eesti Antropomeetriaregistri Aastaraamat, 1999, 99-118<br />
23. Loolaid K, Loolaid V, Kaarma H, Saluste L. Kehaehitus ja toitumine Tartu keskkoolide tütarlastel.<br />
Eesti Antro-pomeetriaregistri Aastaraamat, 1999, 129-133.<br />
24. Loolaid V. Kääriku toitumiskursused (1990-1999). Kümme aastat Kääriku toitumiskursusi. Materjalide<br />
kogumik, Tartu, 1999,7-10<br />
25. Kaarma H, Saluste L. Kehaehituse andmete kasutamine toitumise uurimisel. Kümme aastat Kääriku<br />
toitumiskursusi. Materjalide kogumik, Tartu, 1999, 18-22.<br />
26. Lintsi M, Loolaid V, Kaarma H. Esmane kogemus kooliõpilaste keharasvasisalduse määramisest<br />
firma OMRON keharasvatestriga. Kümme aastat Kääriku toitumiskursusi. Materjalide kogumik,<br />
Tartu, 1999, 36-44.<br />
27. Loolaid K, Loolaid V, Kaarma H, Saluste L. Tartu gümnaasiumide tütarlaste vitamiinide ja mineraalainete<br />
tarbimine ning kehaehitus. Kümme aastat Kääriku toitumiskursusi. Materjalide kogumik,<br />
Tartu, 1999, 45-51.<br />
28. Saluste L, Saluste L, Puss K. Antropomeetrilised mõõtmised Maarjamõisa Polikliinikus. Kümme<br />
aastat Kääriku toitumiskursusi. Materjalide kogumik, Tartu, 1999, 71-73.<br />
29. Hussar P, Märtson A, Hussar Ü, Haviko T, Roosaar P, Toom A, Vähi HV. Roti sääreluu posttraumaatilinereparatsioon.<br />
EestiArst, 2000, 2,68-76.<br />
15
SECTION I: APPENDIXES<br />
30. Loime L, Orrin T, Roosaar P, Sepp E. Morphology <strong>of</strong> liver and pancreas in light microscopy following<br />
truncal vagotomy. Folia Baeriana, 1999, 7, 116 - 128.<br />
31. Aunapuu M, Arend A, Suuroja T, Pechter Ü, Gerškevitš E, Marjamägi MM, Ots M, Sepp E Madaladoosilise<br />
radiatsiooni toime eksperimentaalselt tekitatud glomeruloskleroosile. Pilootuuring.<br />
Eesti Loomaarstlik Ringvaade, 1999, 25, 6, 139-141.<br />
32. Aunapuu M, Pechter Ü, Suuroja T, Ots M, Sepp E. Neeru struktuursed muutused 5/6 nefroktoomia<br />
järgselt. Pilootuuring. Veterinaarmeditsiin 2000, Tartu, 2000, 14-17.<br />
33. Aunapuu M, Suuroja T, Sepp E, Pechter Ü, Ots M. Ultrastruktuuri muutustest neerukehakestes.<br />
eesti Loomaarstlik Ringvaade 2000, 5-6, 205-207.<br />
34. Kolts I, Tomusk H, Raudheiding A. Õlaliigese Hilli-Sachsi tüüpi ebastabiilsuse kliinilis-anatoomilised<br />
alused. Eesti Arst, Lisa 1, 2000, 21-23<br />
35. Ilves Annunziata AR., Veldre G, Saluste L, Pitsi T, Süvalep I, Viin L, Vainu J. Ülevaade Eesti väikelaste<br />
tervise ja toitumise uuringu tulemustest I Väikelaste toitumine ja perede sotsiaalmajanduslik<br />
olukord. Eesti Arst, 2000,79;3, 142-146<br />
36. Ilves Annunziata AR, Veldre G, Saluste L, Pitsi T, Süvalep I, Viin L, Vainu J. Ülevaade Eesti väikelaste<br />
tervise ja toitumise uuringu tulemustest II Väikelaste tervisenäitajad ja kehaline areng Eesti<br />
Arst 2000,79;7, 389-399<br />
37. Lintsi M, Kaarma H, Saluste L, Eesti 18-aastaste noormeeste antropomeetriline iseloomustus<br />
Eesti Arst 2000,79;10, 608-613<br />
38. Kaarma H, Õun K, Ehrenberg A, Jannus L, TÜ Naistekliiniku statsionaaris viibinute andmebaas<br />
Eesti Antropomeetriaregistri Aastaraamat 2000, Tartu, 2000, 29-31<br />
39. Kasmel J, Kasmel T, Pr<strong>of</strong>. Juhan Auli esimesest antropoloogia loengukursusest 1940. Aasta<br />
kevadsemestril Eesti Antropomeetriaregistri Aastaraamat 2000, Tartu, 2000, 32-36<br />
40. Kirss Ü, Õun K, 0-2-aastaste Eesti laste kehakaalu, -pikkuse ja pea ümbermõõdu keskmised<br />
väärtused ning nende prognoosimise võimalused sünniandmeid kasutades Eesti Antropomeetriaregistri<br />
Aastaraamat 2000, Tartu, 2000, 37-48<br />
41. Lintsi M, Kaarma H, Saluste L, Kirss Ü, Vasar V, 17-aastaste noorukite keharasvasisalduse ja<br />
kehaehitusstruktuuri seostest Eesti Antropomeetriaregistri Aastaraamat 2000, Tartu , 2000, 56-68<br />
42. Õun K, Ülevaade Eesti antropomeetriaregistrist. Eesti Antropomeetriaregistri Aastaraamat 2000,<br />
Tartu, 2000, 170-178<br />
TEXTBOOK AND MANUALS<br />
1. Tehver J, Hussar Ü. Meditsiinihistoloogia seletav sõnaraamat, eesti, vene, inglise ja saksa keeles.<br />
Tartu, TÜ Kirjastus, 1996, 116 lk<br />
2. Sepp E. Inimese topoanatoomia. 1997, 247 lk.<br />
3. Tapfer. H. Inimese keha arterid. Tartu, TÜ Kirjastus, 1998, 50 lk.<br />
4. Kaarma H, Saluste L, Thetl<strong>of</strong>f M, Peterson J, Riive M, Salundi U, Veldre G, Rand J. Body structure<br />
<strong>of</strong> nonpregnant and pregnant women and newborns. Study Aid. Tartu, TÜ kirjastus, 1998. 67 lk.<br />
16
APPENDIX I-VII<br />
Academic and administrative personnel: <strong>Department</strong> <strong>of</strong> Anatomy<br />
<strong>ANATOMY</strong><br />
<strong>Name</strong> Title Load Area Gender Birth year Scientific degree Year <strong>of</strong> commencement Labour time (y)<br />
1. Helle Tapfer Docent 1,00 Anatomy Female 1937 Cand.Sci 1970 38<br />
2. Ennu Sepp Pr<strong>of</strong>essor 1,00 Regional and clinical anatomy Male 1938 Dr.Sci 1973 36<br />
3. Aade Liigant Docent 1,00 Anatomy Female 1939 Cand.Sci 1971 36<br />
4. Ivo Kolts Docent 1,00 Anatomy Male 1957 Ph.D 1993 19<br />
5. Andres Arend Docent 1,00 Histology Male 1958 Cand.Sci 1986 17<br />
6. Peeter Roosaar Docent 1,00 Histology Male 1938 Cand.Sci 1982 35<br />
7. Alla Mõttus Lecturer 1,00 Regional and clinical anatomy Female 1940 Cand.Sci 1974 26<br />
8. Eleonora Rajavee Assistant 1,00 Anatomy Female 1940 26<br />
9. Hannes Tomusk Assistant 1,00 Anatomy Male 1954 14<br />
10. Elle Põldoja Assistant 1,00 Anatomy Female 1963 10<br />
11. Kersti Kokk Assistant 1,00 Anatomy Female 1964 10<br />
12. Marge Soom Assistant 1,00 Histology Female 1966 3<br />
13. Jana Peterson Assistant 1,00 Regional and clinical anatomy Female 1968 1<br />
14. Piret Hussar Assistant 0,50 Histology Female 1971 10<br />
15. Liina Pärnsalu Sr. Technical staff 1,00 Female 1968 4<br />
16. Helle Evi Simovart Sr. Technical staff 1,00 Female 1943 Cand.Sci 1974 5<br />
17. Agu Raudheiding Sr. Technical staff 1,00 Male 1960 1<br />
18. Marina Aunapu Sr. Technical staff 1,00 Female 1953 M.Sc 1998 8<br />
19. Kaia Tohu Sr. Technical staff 1,00 Female 1968 2<br />
20. Helgi Mutso Technical staff 1,00 Female 1941 6<br />
21. Eve Proovel Technical staff 1,00 Female 1972 9<br />
22. Kersti Värton Technical staff 1,00 Female 1953 2<br />
23. Tõnis Kripson Sr. Preparator 1,00 Male 1949 5<br />
24. Mare-Ann Tammaru Sr. Preparator 1,00 Female 1949 5<br />
25. Laila Jaomaa Sr. Preparator 1,00 Female 1970 6<br />
26. Inna Lass Sr. Preparator 1,00 Female 1973 5<br />
1 Cand.Sci & Dr.Sci are degrees <strong>of</strong> <strong>the</strong> Former Soviet Union which correspond to a Ph.D and Dr.Med, respectively<br />
17
APPENDIX I-VIII<br />
Curriculum Vitae <strong>of</strong> <strong>the</strong> staff<br />
<strong>ANATOMY</strong><br />
TAPFER, HELLE Date <strong>of</strong> birth: 26. November 1937 Gender: female Citizenship: Estonian Address: Tamme põik<br />
35-5, Tartu, Estonia Educational history: 1957-1962 University <strong>of</strong> Tartu , Faculty <strong>of</strong> Medicine 1966- 1969 University<br />
<strong>of</strong> Tartu, Postgraduate studentship Academic degrees (with year and university): 1970 University <strong>of</strong><br />
Tartu, Cand.Sci , Dissertation "On <strong>the</strong> arrangement <strong>of</strong> intraorganic vessels <strong>of</strong> <strong>the</strong> humans Kidney and its correlation<br />
to <strong>the</strong> calyco-pelvic system" Employment and pr<strong>of</strong>essional experience: 1962 - 1966 University <strong>of</strong> Tartu,<br />
Institute <strong>of</strong> Anatomy, Assistant 1966 - 1969 University <strong>of</strong> Tartu, Institute <strong>of</strong> Anatomy, PhD student 1969 - 2003<br />
University <strong>of</strong> Tartu, Institute <strong>of</strong> Anatomy, Pr<strong>of</strong>. Assistant Administrative experience: 1995 - University <strong>of</strong> Tartu,<br />
Institute <strong>of</strong> Anatomy, Head <strong>of</strong> Chair <strong>of</strong> Anatomy 1998 - University <strong>of</strong> Tartu, Institute <strong>of</strong> Anatomy, Head <strong>of</strong> Institute<br />
<strong>of</strong> Anatomy Honours and awards: International gold medals for macroanatomical preparations - Moscow,1982;<br />
Leipzig, 1983 Medal <strong>of</strong> anatomists, Pr<strong>of</strong>. A. Rauber, 1991 Medal <strong>of</strong> Faculty <strong>of</strong> Medicine, University <strong>of</strong> Tartu, 1997<br />
Membership in academic and scientific societies: Member <strong>of</strong> Estonian Society <strong>of</strong> Morphology Member <strong>of</strong><br />
IFAA Current research program and grants: Research field comprises <strong>the</strong> macroanatomical problems -<br />
comparative-anatomical research <strong>of</strong> Renal Artery and Renal Segmental structure on human´s and different<br />
mammals (150 cases) variability <strong>of</strong> <strong>the</strong> maxillary artery in Estonian population (on <strong>the</strong> base <strong>of</strong> dissection material<br />
<strong>of</strong> 50 cadavers). The current research - septic shock with disseminated micr<strong>of</strong>oci in multiple organs in man and in<br />
experiment. H. Tapfer is <strong>the</strong> autor research publications 75, acknowledged national, international jurnals (10 CC,<br />
Biosis) and author <strong>of</strong> 2 handbooks for students <strong>of</strong> physicians. Estonian Science Foundation, grant No. 4380<br />
Morphological basis <strong>of</strong> immunological reaction in clinical and experimental sepsis Supervision <strong>of</strong> dissertations:<br />
Ph.D. student Kersti Kokk, research program: "Microvascular permeability <strong>of</strong> <strong>the</strong> male reproductive tract. Testicular<br />
endo<strong>the</strong>lial cells". Publications: 75, per review 10<br />
KOKK, KRSTI Date <strong>of</strong> birth: January 15, 1964 Gender: female Citizenship: Estonian Address: Pohla 6-4, Tartu,<br />
Estonia Educational history: Diploma license Med. University <strong>of</strong> Tartu, 29.06.1990 MB-I No 117553 1999 -<br />
Ph.D. student (2 year) Academic degrees (with year and university): - Employment and pr<strong>of</strong>essional experience:<br />
University <strong>of</strong> Tartu, Faculty <strong>of</strong> Medicine, Institute <strong>of</strong> Anatomy 1990-1993, University <strong>of</strong> Tartu, Institute <strong>of</strong><br />
Anatomy, laboratory assistant University <strong>of</strong> Tartu, Institute <strong>of</strong> anatomy, assistant <strong>of</strong> anatomy - PhD student Administrative<br />
experience: - Honours and awards: - Membership in academic and scientific societies: Member<br />
<strong>of</strong> <strong>the</strong> Morfological Society <strong>of</strong> Estonia Current research program and grants: Ph.D. student research program:<br />
"Microvascular permeability <strong>of</strong> <strong>the</strong> male reproductive tract. Testicular endo<strong>the</strong>lial cells". Grants: 1. CIMO (Centre<br />
<strong>of</strong> International Mobility). Finland 2. A. and E. Traks Foundation, USA 3. H. and H. Einpaul´s Foundation, Sweden<br />
4. Ph.D. student grant - University <strong>of</strong> Tartu Supervision <strong>of</strong> dissertations:Pr<strong>of</strong>. assist. Helle Tapfer, University <strong>of</strong><br />
Tartu Pr<strong>of</strong>. assist. Pasi Pöllänen, University <strong>of</strong> Turku Publications: 6<br />
LIIGANT, AADE Date <strong>of</strong> birth: 23.12.1939 Gender: female Citizenship: Estonian Address: Anne 59-40, Tartu,<br />
Estonia Educational history: 1958 graduated from Tartu Secondary School No. 5 1958-64 University <strong>of</strong> Tartu,<br />
Medical Faculty, <strong>the</strong>rapy Academic degrees (with year and university): 1971 University <strong>of</strong> Tartu, Cand.Sci Employment<br />
and pr<strong>of</strong>essional experience: University <strong>of</strong> Tartu, <strong>Department</strong> <strong>of</strong> Anatomy, assistant University <strong>of</strong><br />
Tartu, <strong>Department</strong> <strong>of</strong> Anatomy, postgraduate student University <strong>of</strong> Tartu, <strong>Department</strong> <strong>of</strong> Anatomy, assistant University<br />
<strong>of</strong> Tartu, <strong>Department</strong> <strong>of</strong> Anatomy, senior lecturer University <strong>of</strong> Tartu, Depart. <strong>of</strong> Anatomy, Assist.Pr<strong>of</strong>. Administrative<br />
experience: - Honours and awards: International awards for anatomical preparations <strong>of</strong> lungs and<br />
kidneys in Tallinn and Moscow (1982) Medal <strong>of</strong> Faculty <strong>of</strong> Medicine, University <strong>of</strong> Tartu, 1999 Membership in<br />
academic and scientific societies: member <strong>of</strong> Estonian Society <strong>of</strong> Morphology Current research program and<br />
grants: Estonian Science Foundation, grant No. 4380 Morphological basis <strong>of</strong> immunological reaction in clinical<br />
and experimental sepsis Supervision <strong>of</strong> dissertations: 1972 Dissertation "Anatomical correlations between lung<br />
veins and structural units" Publications: 60<br />
TOMUSK, HANNES Date <strong>of</strong> birth: 23.05.1954 Gender: male Citizenship: Estonian Address: Anne 53 -20, Tartu,<br />
Estonia Educational history: University <strong>of</strong> Tartu, Diploma licence Med. Academic degrees (with year and university):-<br />
Employment and pr<strong>of</strong>essional experience: 1982 - 1986 University <strong>of</strong> Tartu, <strong>Department</strong> <strong>of</strong> Anatomy,<br />
senior preparator 1986 - 1990 University <strong>of</strong> Tartu, <strong>Department</strong> <strong>of</strong> Anatomy, senior technician 1990 - 1995 University<br />
<strong>of</strong> Tartu, <strong>Department</strong> <strong>of</strong> Anatomy, assistant 1995 - 1996 University <strong>of</strong> Tartu, <strong>Department</strong> <strong>of</strong> Anatomy, senior<br />
assistant 1996 - 1999 University <strong>of</strong> Tartu, <strong>Department</strong> <strong>of</strong> Anatomy, assistant 1999 - University <strong>of</strong> Tartu, <strong>Department</strong><br />
<strong>of</strong> Anatomy, assistant Administrative experience:- Honours and awards:- Membership in academic and<br />
scientific societies: : Member <strong>of</strong> <strong>the</strong> Morfological Society <strong>of</strong> Estonia Current research program and grants:<br />
Estonian Science Foundation, grant No 4367 Anatomical, clinical and rehabilitational complex research <strong>of</strong> <strong>the</strong><br />
shoulder region pathologies. Supervision <strong>of</strong> dissertations:- Publications:18<br />
KOLTS, IVO Date <strong>of</strong> birth: 07.February 1957 Gender: male Citizenship: Estonian Address: Tähe 7-5, 51010<br />
Tartu, Estonia Educational history: Tallinn Secondary School No.7, 1975 University <strong>of</strong> Tartu Medical Faculty,<br />
1975 - 1981 Kiel University Germany, 1990 - 1992 Academic degrees (with year and university): Dr. med. 1993,<br />
Kiel University Employment and pr<strong>of</strong>essional experience: University <strong>of</strong> Tartu, Institute <strong>of</strong> Anatomy Senior laboratory<br />
worker 1981 - 1984 Assistant 1984 - 1990 Doctor studies 1990 - 1993 Senior assistant 1994 - 1997 Ass.<br />
pr<strong>of</strong>essor 1997 Administrative experience: - Honours and awards: - Membership in academic and scientific<br />
19
SECTION I: APPENDIXES<br />
societies: Morphological Society <strong>of</strong> Estonia Anatomische Gesellschaft, Germany Current research program<br />
and grants: Functional anatomy <strong>of</strong> <strong>the</strong> locomotor apparatus. Grant: Anatomical, clinical and rehabilitational complex<br />
research <strong>of</strong> <strong>the</strong> shoulder region pathologies. Estonian Science Foundation 2000 - 2003 Environmental research<br />
Grant: Sonoelectrochemical Analysis <strong>of</strong> Heavy Metals Collaborative researcher. Wellcome Trust 2001 -<br />
2003 Supervision <strong>of</strong> dissertations: University <strong>of</strong> Tartu, Mati Merila dissertation: Anatomical and biomechanical<br />
basis for <strong>the</strong> shoulder joint capsule surgical treatment. Publications: 26 5 publications (Medline, CC) 1 publicated<br />
Dissertation 20 local publications and international conference abstracts<br />
RAJAVEE, ELEONORA Date <strong>of</strong> birth:15 May 1940 Gender: female Citizenship: Estonian Address: Kaunase pst.<br />
36-6, Tartu, Estonia Educational history: Diploma license Med. University <strong>of</strong> Tartu, 1968 Academic degrees<br />
(with year and university): - Employment and pr<strong>of</strong>essional experience: 1968 - 1971University <strong>of</strong> Tartu, <strong>Department</strong><br />
<strong>of</strong> Farmacology, Junior Researcher 1971 - 1974Rebublical Clinical Hospital, Tartu, Transplant. <strong>Department</strong>,<br />
physician University <strong>of</strong> Tartu, <strong>Department</strong> <strong>of</strong> Anatomy, assistant 1991 - 1996University <strong>of</strong> Tartu, <strong>Department</strong><br />
<strong>of</strong> Anatomy, Senior Assistant 1996 - 1997University <strong>of</strong> Tartu, <strong>Department</strong> <strong>of</strong> Anatomy, Extraordinary Assistant<br />
1997 - 2000University <strong>of</strong> Tartu, <strong>Department</strong> <strong>of</strong> Anatomy, assistant 2000 - 2003 University <strong>of</strong> Tartu, <strong>Department</strong><br />
<strong>of</strong> Anatomy, assistant Administrative experience: - Honours and awards: - Membership in academic and<br />
scientific societies: Morphological Society <strong>of</strong> Estonia Current research program and grants: Estonian<br />
Science Foundation, grant No. 4367, Anatomical, clinical and rehabilitational complex research <strong>of</strong> <strong>the</strong> shoulder<br />
region pathologies. Supervision <strong>of</strong> dissertations: - Publications: 34<br />
PÕLDOJA, ELLE Date <strong>of</strong> birth: 02.01.1963 Gender: female Citizenship: Estonian Address: Ringtee 3-54, Tartu,<br />
Estonia Educational history: Diploma license Med., University <strong>of</strong> Tartu 1990 Academic degrees (with year and<br />
university): - Employment and pr<strong>of</strong>essional experience: 1990 - 1991 University <strong>of</strong> Tartu, Hospital <strong>of</strong> Maarjamõisa,<br />
surgery practical work 1991 - 1993 University <strong>of</strong> Tartu, <strong>Department</strong> <strong>of</strong> Anatomy, research worker 1994 -<br />
1997 University <strong>of</strong> Tartu, <strong>Department</strong> <strong>of</strong> Anatomy, senior laboratory assistant 1997 - 2000 University <strong>of</strong> Tartu, <strong>Department</strong><br />
<strong>of</strong> Anatomy, assistant 2000 - 2003 University <strong>of</strong> Tartu, <strong>Department</strong> <strong>of</strong> Anatomy, assistant Administrative<br />
experience: - Honours and awards: - Membership in academic and scientific societies: Member <strong>of</strong> Baltic-Germany<br />
Physician Society Morphological Society <strong>of</strong> Estonia Current research program and grants: Estonian<br />
Science Foundation, grant No. 4380 Morphological basis <strong>of</strong> immunological reaction in clinical and<br />
experimental sepsis Estonian Science Foundation, grant No. 3949, "New perspectives in pharmacology <strong>of</strong><br />
neurodegenerative disorders" Supervision <strong>of</strong> dissertations: - Publications: 8<br />
SEPP, ENNU Date <strong>of</strong> birth: November 13, 1938 Gender: Male Citizenship: Estonian Address: Räni põik 2, Tartu<br />
50403 Educational history: Higher education, University <strong>of</strong> Tartu, medicine Academic degrees (with year and<br />
university): Candidate <strong>of</strong> Medicine in 1967 Tartu Doctor <strong>of</strong> Medicine in 1973 "Posttrombophlebitic syndrome and<br />
its surgical treatment", Tartu Employment and pr<strong>of</strong>essional experience: 1958-1964 student <strong>of</strong> <strong>the</strong> University <strong>of</strong><br />
Tartu (Faculty <strong>of</strong> medicine); from 1964 until now <strong>the</strong> assistant, pr<strong>of</strong>essor and head <strong>of</strong> <strong>the</strong> chair <strong>of</strong> operative surgery<br />
and topographic anatomy (now surgical anatomy); 1992-1968 head <strong>of</strong> <strong>the</strong> <strong>Department</strong> <strong>of</strong> Anatomy. Postdoctoral<br />
research training in Moscow, Novosibirsk, Tallinn, Helsinki, Lund and Turu. Administrative experience:<br />
1978-1990 Vice-dean <strong>of</strong> <strong>the</strong> Faculty <strong>of</strong> Medicine <strong>of</strong> <strong>the</strong> University <strong>of</strong> Tartu 1979-1986 Member <strong>of</strong> <strong>the</strong> Council <strong>of</strong><br />
Scientific Medicine <strong>of</strong> <strong>the</strong> Ministry <strong>of</strong> Public Health <strong>of</strong> ESSR, 1985-1990 Vice-chairman <strong>of</strong> <strong>the</strong> Council <strong>of</strong> graduating<br />
<strong>the</strong> degrees <strong>of</strong> doctor in <strong>the</strong> field <strong>of</strong> surgery at <strong>the</strong> University <strong>of</strong> Tartu, 1987-1993 Member <strong>of</strong> <strong>the</strong> commission<br />
<strong>of</strong> certificating <strong>the</strong> surgeons at <strong>the</strong> Ministry <strong>of</strong> Public Health Honours and awards: National award <strong>of</strong> <strong>the</strong> Soviet<br />
Estonia in 1982 Membership in academic and scientific societies:Member <strong>of</strong> <strong>the</strong> Society <strong>of</strong> Surgious <strong>of</strong> Germany,<br />
Member <strong>of</strong> <strong>the</strong> society <strong>of</strong> Flebology <strong>of</strong> France, Member <strong>of</strong> <strong>the</strong> New York Academy <strong>of</strong> Sciences, Member <strong>of</strong><br />
Tartu Association <strong>of</strong> Surgeous et Baltic Association <strong>of</strong> Surgeous . Current research program and grants: Reconstructive<br />
surgery <strong>of</strong> vessels, <strong>the</strong> problems <strong>of</strong> surgical treatment <strong>of</strong> <strong>the</strong> hip, surgical treatment <strong>of</strong> gastric and<br />
duodenal ulcers and reparative regeneration <strong>of</strong> gastric mucosa. Grant <strong>of</strong> <strong>the</strong> Estonian Scientific Foundation<br />
(1998-2001) "Reparative regeneration <strong>of</strong> gastric and intestinal mucosa in case <strong>of</strong> vagotomy and Helicobacter pylori<br />
colonisation." Supervision <strong>of</strong> dissertations: Alla Mõttus Cand. SCI 1974 UT Publications: 196<br />
MÕTTUS, ALLA Date <strong>of</strong> birth: April 06. 1940 Gender: Female Citizenship: Estonian Address: Rebase 7 - 9, Tartu<br />
Educational history: The First Moskow Institute <strong>of</strong> Medicine 1957-1963 Academic degrees (with year and university):<br />
Cand. SCI 1974 UT Employment and pr<strong>of</strong>essional experience: The Railway Hospital on Sakhalin<br />
Physician 1963-1966; Emergency in Tallinn Physician 1966-1967; Tartu Ambulance surgeon 1967-1968; The<br />
Tartu University Faculty <strong>of</strong> Medicine, aspirant, assistant, dotsent from 1968 Administrative experience: None<br />
Honours and awards: None Membership in academic and scientific societies: None Current research program<br />
and grants: None Supervision <strong>of</strong> dissertations: None Publications: 42<br />
AREND, ANDRES Date <strong>of</strong> birth: October 8, 1958 Gender: Male Citizenship: Estonian Address: Aardlavälja 3,<br />
Tartu 50112, Estonia Educational history: University <strong>of</strong> Tartu, Faculty <strong>of</strong> Medicine 1977-1983; postgraduate<br />
student 1983-1986, University <strong>of</strong> Tartu Academic degrees (with year and university): Cand.Sci. (medicine), 1986<br />
(Ph.D.), University <strong>of</strong> Tartu Employment and pr<strong>of</strong>essional experience: assistant 1987-88, <strong>Department</strong> <strong>of</strong><br />
Histology and Embryology <strong>of</strong> <strong>the</strong> University <strong>of</strong> Tartu; lecturer 1989-1991, <strong>Department</strong> <strong>of</strong> Histology and<br />
Embryology <strong>of</strong> <strong>the</strong> University <strong>of</strong> Tartu; docent (assistant pr<strong>of</strong>essor) since 1991, <strong>Department</strong> <strong>of</strong> Anatomy <strong>of</strong> <strong>the</strong><br />
University <strong>of</strong> Tartu Administrative experience: Coordinator <strong>of</strong> foreign relations and international students <strong>of</strong> <strong>the</strong><br />
Medical Faculty <strong>of</strong> <strong>the</strong> University <strong>of</strong> Tartu 1996-1999; head <strong>of</strong> <strong>the</strong> Chair <strong>of</strong> Histology since 1998 Honours and<br />
awards: award for <strong>the</strong> outstanding poster at <strong>the</strong> 3 rd International Congress <strong>of</strong> Pathophysiology (Lahti, 1998)<br />
20
<strong>ANATOMY</strong><br />
Membership in academic and scientific societies: Member <strong>of</strong> <strong>the</strong> Morphological Society <strong>of</strong> Estonia; member <strong>of</strong><br />
<strong>the</strong> International Federation <strong>of</strong> Associations <strong>of</strong> Anatomists Current research program and grants: a) Factors<br />
influencing reparative regeneration <strong>of</strong> <strong>the</strong> connective tissue; b) Role <strong>of</strong> eicosanoids in several organs (corpus<br />
luteum, mucosa <strong>of</strong> <strong>the</strong> intestinal tract, wound tissue). Grant from <strong>the</strong> Estonian Science Foundation: Activity and<br />
localization <strong>of</strong> prostaglandin synthases (COX-1 and COX-2) in rat corpus luteum. Supervision <strong>of</strong> dissertations:<br />
M. Aunapuu, master <strong>of</strong> veterinary science, 1998 Publications: 57<br />
SOOM, MARGE Date <strong>of</strong> birth: 31.05.1966 Gender: Female Citizenship: Estonian Address: Sangla 44-2, Tartu,<br />
Estonia Educational history: 1984-1991 University <strong>of</strong> Tartu, Faculty <strong>of</strong> Medicine Academic degrees (with year<br />
and university): - Employment and pr<strong>of</strong>essional experience: 1991-1993 - Central Hospital <strong>of</strong> Tallinn; physicianintern<br />
1993-1995 - Policlinic <strong>of</strong> Lasnamae; physician since 1998 - University <strong>of</strong> Tartu, <strong>Department</strong> <strong>of</strong> Anatomy;<br />
assistant Administrative experience: - Honours and awards: - Membership in academic and scientific societies:<br />
member <strong>of</strong> <strong>the</strong> Morphological Society <strong>of</strong> Estonia; member <strong>of</strong> Internatinal Society <strong>of</strong> Associations <strong>of</strong> Anatomists<br />
Current research program and grants: Role <strong>of</strong> eicosanoids in corpus luteum Supervision <strong>of</strong> dissertations:<br />
- Publications: 1<br />
ROOSAAR, PEETER Date <strong>of</strong> birth: December 5, 1938 Gender: Male Citizenship: Estonian Address: Aardla 9a-19,<br />
Tartu, Estonia Educational history: University <strong>of</strong> Tartu, Faculty <strong>of</strong> Medicine, 1965 Academic degrees (with year<br />
and university): Cand. Sci. (medicine) 1982 (Ph.D.), University <strong>of</strong> Tartu Employment and pr<strong>of</strong>essional experience:<br />
1965-1977 Central Laboratory <strong>of</strong> Medicine <strong>of</strong> <strong>the</strong> University <strong>of</strong> Tartu; researcher 1977-1982 <strong>Department</strong> <strong>of</strong><br />
Histology and Embryology <strong>of</strong> <strong>the</strong> University <strong>of</strong> Tartu; assistant 1982-1988 <strong>Department</strong> <strong>of</strong> Histology and Embryology<br />
<strong>of</strong> <strong>the</strong> University <strong>of</strong> Tartu; senior lecturer since 1988 <strong>Department</strong> <strong>of</strong> Histology and Embryology <strong>of</strong> <strong>the</strong> University<br />
<strong>of</strong> Tartu; docent (assistant pr<strong>of</strong>essor) Administrative experience: 1967-1972 head <strong>of</strong> <strong>the</strong> Sector <strong>of</strong> Experimental<br />
Surgery <strong>of</strong> <strong>the</strong> Central Laboratory <strong>of</strong> Medicine <strong>of</strong> <strong>the</strong> University <strong>of</strong> Tartu Honours and awards: 1988 certificate<br />
<strong>of</strong> honour from <strong>the</strong> Ministry <strong>of</strong> Health <strong>of</strong> <strong>the</strong> Estonian SSR Membership in academic and scientific societies:<br />
Member <strong>of</strong> <strong>the</strong> Morphological Society <strong>of</strong> Estonia; member <strong>of</strong> International Society <strong>of</strong> Associations <strong>of</strong> Anatomists<br />
Current research program and grants: a) problems <strong>of</strong> vascular surgery; b) reparative regeneration <strong>of</strong><br />
bone tissue; c) microcirculation <strong>of</strong> <strong>the</strong> brain; d) surgical treatment <strong>of</strong> congenital malformations <strong>of</strong> <strong>the</strong> oral cavity; e)<br />
pathogenesis <strong>of</strong> <strong>the</strong> gastric and duodenal ulcers Supervision <strong>of</strong> dissertations: consultant <strong>of</strong> <strong>the</strong> histological part<br />
<strong>of</strong> several candidate and doctoral dissertations Publications: 138<br />
HUSSAR, PIRET Date <strong>of</strong> birth: March 9, 1971 Gender: Female Citizenship: Estonian Address: Ilmatsalu 48-27,<br />
Tartu Educational history: Faculty <strong>of</strong> Medicine <strong>of</strong> <strong>the</strong> Univrsity <strong>of</strong> Tartu, 1991-1997; postgraduate student (doctorant)<br />
<strong>of</strong> <strong>the</strong> University <strong>of</strong> Tartu since 1997 Academic degrees (with year and university): - Employment and<br />
pr<strong>of</strong>essional experience: 1989-91 orderly <strong>of</strong> <strong>the</strong> Tartu Children´s Hospital 1995-97 laboratory technician <strong>of</strong> <strong>the</strong><br />
grant <strong>of</strong> <strong>the</strong> Estonian Science Foundation 1997-98 assistant and doctorant <strong>of</strong> histology at <strong>the</strong> <strong>Department</strong> <strong>of</strong><br />
Anatomy <strong>of</strong> <strong>the</strong> University <strong>of</strong> Tartu 1998-2000 research fellow <strong>of</strong> Institute <strong>of</strong> Molecular and Cell Regulation at<br />
Gunma University (Japan) since 01.04.2000 assistant and doctorant <strong>of</strong> histology at <strong>the</strong> <strong>Department</strong> <strong>of</strong> Anatomy <strong>of</strong><br />
<strong>the</strong> University <strong>of</strong> Tartu Administrative experience: 1998 member <strong>of</strong> <strong>the</strong> Council <strong>of</strong> <strong>the</strong> Medical Faulty <strong>of</strong> <strong>the</strong><br />
Univrsity <strong>of</strong> Tartu. Honours and awards: - Membership in academic and scientific societies: member <strong>of</strong> <strong>the</strong><br />
Estonian Society <strong>of</strong> Morphology; member <strong>of</strong> Internatinal Society <strong>of</strong> Associations <strong>of</strong> Anatomists Current research<br />
program and grants: Posttraumatic remodeling (resorption, repair) <strong>of</strong> chondro- and osteogenesis and its<br />
hormonal regulation; b) Transmembrane glucose transport in different tissues by IF. Supervision <strong>of</strong> dissertations:<br />
- Publications: 12 (publ. - 6; submitted - 2; abstr. - 4)<br />
PETERSON, JANA Date <strong>of</strong> birth: May, 08. 1968 Gender: Female Citizenship: Estonian Address: Paldiski mnt 20-<br />
22, Tallinn Educational history: Narva Secondary School, 1986; University <strong>of</strong> Tartu, Faculty <strong>of</strong> Medicine, graduated<br />
in 1993. Academic degrees (with year and university): None Employment and pr<strong>of</strong>essional experience:<br />
The Estonian Insurals medical advisor 1998; The Medical School <strong>of</strong> Tallinn, <strong>the</strong> teacher 1998. Administrative<br />
experience: None Honours and awards: None Membership in academic and scientific societies: None Current<br />
research program and grants: None Supervision <strong>of</strong> dissertations: None Publications: 18<br />
21
BIOCHEMISTRY<br />
<strong>Name</strong> <strong>of</strong> <strong>Department</strong>: <strong>Department</strong> <strong>of</strong> Biochemistry<br />
Head <strong>of</strong> <strong>the</strong> <strong>Department</strong>: Pr<strong>of</strong>essor Mihkel Zilmer<br />
<strong>Name</strong> <strong>of</strong> <strong>the</strong> Chair: Medical Biochemistry<br />
Head <strong>of</strong> <strong>the</strong> Chair: Pr<strong>of</strong>essor Mihkel Zilmer<br />
Subject codes: ARBK.01.001; ARBK.01.002; ARBK.01.003<br />
ARBK.01.010; ARBK.01.011<br />
I. CONTENT OF THE TEACHING<br />
1. Short description <strong>of</strong> <strong>the</strong> main study and student evaluation methods applied<br />
at <strong>the</strong> department.<br />
Method <strong>of</strong> learning/teaching: a problem-based lectures and a problemoriented<br />
seminars/practical work pushing <strong>the</strong> students to develop biochemicalclinical<br />
thinking.<br />
Assessment methods: test papers, sum <strong>of</strong> practical exercises and seminars<br />
evaluations, written summaries on <strong>the</strong> special topics and preliminary examination.<br />
2. How have <strong>the</strong> aims and objectives described in <strong>the</strong> curriculum changed<br />
during <strong>the</strong> past five years?<br />
The strategies for medical education are formulated by <strong>the</strong> World Federation<br />
for Medical Education. The main principle has been to integrate <strong>the</strong> fundamental<br />
disciplines with clinical disciplines throughout <strong>the</strong> studium. It has been<br />
emphasized that for fully understanding <strong>the</strong> disease it is crucially important to<br />
look for <strong>the</strong> structural or functional abnormalities on <strong>the</strong> molecular and cellular<br />
level (abnormal structure and function = human disease). This is why explaining<br />
<strong>of</strong> <strong>the</strong> normal structure and function and <strong>the</strong> possible abnormalities lies <strong>the</strong><br />
basic goal for Medical Biochemistry. The knowledge <strong>of</strong> contemporary Medical<br />
Biochemistry allows it to begin exploring and explaining <strong>the</strong> molecular basis <strong>of</strong><br />
<strong>the</strong> central problems <strong>of</strong> human organism (cellular differentiation, cancerogenesis,<br />
neural activity, memory, immunological competence, apoptosis, function <strong>of</strong><br />
biomembranes, genetic diseases, diseases <strong>of</strong> still unknown or multifactorial<br />
origin). Therefore, Medical Biochemistry role in <strong>the</strong> development <strong>of</strong> o<strong>the</strong>r<br />
medical sciences (physiology, pharmacology, pharmacy, endocrinology,<br />
pathophysiology etc) has been constantly growing. Concerning mentioned<br />
above, <strong>the</strong> principal changes undertaken in <strong>the</strong> curriculum are as follows:<br />
The traditional course in Biochemistry is replaced by strongly human organism<br />
and clinical practice oriented Medical Biochemistry course to develop biochemical-clinical<br />
thinking and to create real contemporary basis for using <strong>the</strong><br />
biochemical experience in <strong>the</strong> practice <strong>of</strong> <strong>the</strong> future medical practitioner and<br />
guarantees <strong>the</strong> systemic acquiring <strong>of</strong> new scientific conceptions needed for<br />
evidence based medicine. To guarantee such change our <strong>Department</strong> has<br />
23
SECTION I: SELF-EVALUATION<br />
24<br />
published six original, user-friendly and strongly human organisms directed<br />
textbooks and monographs for course <strong>of</strong> Medical Biochemistry.<br />
The course <strong>of</strong> human organism oriented Medical Biochemistry was integrated<br />
and developed towards both modern molecular medicine and practical medicine.<br />
To facilitate such trends also <strong>the</strong> teachers from <strong>the</strong> Clinical <strong>Department</strong>s<br />
and visiting lecturers <strong>of</strong> Molecular Medicine are invited to give some special<br />
lectures.<br />
3. Describe <strong>the</strong> strengths and weaknesses <strong>of</strong> <strong>the</strong> teaching in your department.<br />
Strengths<br />
Our new, original and strongly Medical Biochemistry oriented textbooks, CD-<br />
ROMs and monographs (in Estonian and English) which are as follows:<br />
1. Medical Biochemistry I. Biomolecules: biochemical and medical aspects.<br />
Ed. M. Zilmer, Tartu, 1996, pp 321, Zilmer, M, Karelson, E, Vihalemm, T.<br />
(in Estonian).<br />
2. Medical Biochemistry II. Human metabolism and diseases: biochemical<br />
and medical aspects. Ed. M. Zilmer, Tartu, 1999, pp 328, Zilmer, M, Karelson,<br />
E, Vihalemm, T. (in Estonian).<br />
3. Introductory Chapters <strong>of</strong> Medical Biochemistry (CD-ROM). Eds. M. Zilmer,<br />
E. Karelson. Tartu University, Dept <strong>of</strong> Biochemistry, Tartu 2001, Zilmer,M,<br />
Soomets,U,Karelson,E, Starkopf, J, Vihalemm,T, Zilmer,K,Rehema, A. (in<br />
Estonian).<br />
4. Introductory Chapters <strong>of</strong> Medical Biochemistry (CD-ROM). Eds. M. Zilmer,<br />
E. Karelson. Tartu University, Dept <strong>of</strong> Biochemistry, Tartu 2001, Zilmer,M,<br />
Soomets,U,Karelson,E, Starkopf, J, Vihalemm,T, Zilmer,K,Rehema, A. (in<br />
English, in press).<br />
5. Medical Biochemistry I. Biomolecules: biochemical and clinical aspects<br />
(CD-ROM). Ed. M. Zilmer, Tartu University, Biomedicum, Tartu, 2001, Zilmer,<br />
M, Karelson, E, Vihalemm, T, Soomets, U, Starkopf, J, Zilmer, K, Rehema,<br />
A (in Estonian and in English, in press).<br />
The research program <strong>of</strong> <strong>the</strong> department is actually quite broad and has a<br />
strong clinical orientation (four international programs are going on). It provides<br />
a broader base <strong>of</strong> experience and expertise to be employed for specific<br />
teaching assignments. This gives depth to <strong>the</strong> teaching, is a source <strong>of</strong> motivation<br />
to <strong>the</strong> teachers, and also <strong>of</strong>fers <strong>the</strong> students a broad range <strong>of</strong> projects to<br />
choose from for <strong>the</strong>ir advanced studies.<br />
Weaknesses<br />
As Medical Biochemistry role in <strong>the</strong> development <strong>of</strong> both o<strong>the</strong>r medical sciences<br />
(physiology, pharmacology, pharmacy, endocrinology, pathophysiology<br />
etc) and clinical practice is constantly growing, more contemporary laboratory<br />
experiments (practical skills) are needed. It means that more small-group<br />
teaching should be developed and present financial deficiency should be
BIOCHEMISTRY<br />
eliminated. Such alterations allow improve individual practical skills <strong>of</strong> students.<br />
4. Describe <strong>the</strong> innovations in your teaching.<br />
As medical education is permanently changing, we started via TEMPUS<br />
(Structural Joint European Project, contract JEP-09270-95: “Restructuring <strong>of</strong><br />
Biochemical Education in <strong>the</strong> University <strong>of</strong> Tartu” 1995-1998) to adapt our curricula<br />
towards problem-oriented teaching, delivering <strong>the</strong> clinical relevant<br />
knowledge and pushing <strong>the</strong> students to develop biochemical-medical thinking<br />
in <strong>the</strong> seminars and avoiding simple loading <strong>the</strong>m with facts. Development <strong>of</strong><br />
new contemporary original textbooks, including CD-ROMs, which cover main<br />
topics <strong>of</strong> Medical Biochemistry, facilitates this process. Since 1999, <strong>the</strong> students<br />
do not waste <strong>the</strong>ir time to write down a lot <strong>of</strong> information and <strong>the</strong>ir intensive<br />
work with problems both in seminars and during <strong>the</strong>ir homework is much<br />
more facilitated/motivated. During <strong>the</strong> last 1-2 years <strong>the</strong> lectures and seminars<br />
have been illustrated with original PowerPoint computerized slides. The role <strong>of</strong><br />
animated computer-shows, to discuss special topics, among <strong>the</strong> teaching<br />
methods is permanently growing. Since 2001, all our programs and plans <strong>of</strong><br />
lectures and seminars will be presented also on internet home page <strong>of</strong> our<br />
<strong>Department</strong> (http://biomedicum.ut.ee/arbk).<br />
5. <strong>Name</strong> <strong>the</strong> factors which most disturb teaching (excluding financial resources).<br />
Good teaching materials, strongly oriented to Medical Biochemistry, do not<br />
practically exist in electronic form even in English. Therefore, <strong>the</strong> development<br />
<strong>of</strong> original and real clinical outcome giving materials and development <strong>of</strong> computer-aided<br />
methods would require a tremendous preparatory work.<br />
II. EVALUATION OF TEACHING<br />
6. How is <strong>the</strong> quality <strong>of</strong> <strong>the</strong> teaching in your department evaluated? How are<br />
<strong>the</strong> content and <strong>the</strong> modes <strong>of</strong> <strong>the</strong> teaching changed on <strong>the</strong> basis <strong>of</strong> <strong>the</strong><br />
evaluation?<br />
There is an open atmosphere between <strong>the</strong> teachers and students. This allows<br />
immediate and direct feedback during and after <strong>the</strong> teaching. Each course is<br />
preceded by a staff meeting, where <strong>the</strong> results <strong>of</strong> questionnaire-based last<br />
student evaluation (carried out systematically in Faculty <strong>of</strong> Medicine) are reviewed<br />
and considered.<br />
III. PEDAGOGIC TRAINING OF STAFF<br />
7. How many <strong>of</strong> <strong>the</strong> teachers have received pedagogic training?<br />
All teachers have received practical training in <strong>the</strong>ir teaching work. A few<br />
teachers have attended formal courses <strong>of</strong> pedagogic training. All teachers<br />
have attended occasional lectures or demonstrations.<br />
25
SECTION I: SELF-EVALUATION<br />
8. Is <strong>the</strong>re a need for fur<strong>the</strong>r pedagogic training?<br />
We believe that teaching skills <strong>of</strong> our staff are reasonably good and obligatory<br />
courses may not improve <strong>the</strong>m significantly. Most <strong>of</strong> teachers have teaching<br />
experience more than 20 years. What is more essential is that <strong>the</strong> all staff<br />
should become more familiar with <strong>the</strong> objective <strong>of</strong> academic education to<br />
deepen and expand <strong>the</strong> intellectual capacities <strong>of</strong> <strong>the</strong> students and not merely<br />
load <strong>the</strong>m with facts.<br />
IV. TEACHING RESOURCES<br />
9. Is <strong>the</strong>re a need for rearrangement <strong>of</strong> <strong>the</strong> teaching resources in your department?<br />
If so, how should this be done?<br />
At present <strong>the</strong>re is no needs for rearrangement <strong>of</strong> <strong>the</strong> teaching resources. All<br />
our teachers are at minimum Ph.D.<br />
V. COORDINATION OF THE TEACHING<br />
10. How is <strong>the</strong> teaching co-ordinate with o<strong>the</strong>r departments? Indicate <strong>the</strong> departments<br />
that are closest to your department.<br />
Coordination <strong>of</strong> teaching is one <strong>of</strong> <strong>the</strong> major purposes <strong>of</strong> <strong>the</strong> Faculty's evaluation<br />
<strong>of</strong> teaching. Considering <strong>the</strong> scientific work we have already a very close<br />
co-operation with many preclinical and clinical departments <strong>of</strong> Faculty. Using<br />
this pathway we started to developed real co-ordination with o<strong>the</strong>r departments<br />
considering <strong>the</strong> teaching. One example: we were happy to introduce<br />
first case in Faculty where one <strong>of</strong> our teachers (J. Starkopf, MD, PhD) works<br />
simultaneously as senior lecture at <strong>Department</strong> <strong>of</strong> Biochemistry and lecturer at<br />
<strong>Department</strong> <strong>of</strong> Anes<strong>the</strong>siology.<br />
The departments that are closest to our department are as follows: Physiology,<br />
Immunology, Pharmacology, Microbiology, Pathological physiology, Human<br />
genetics, Pharmacy<br />
VI. FUTURE PLANS<br />
11. Future plans to improve <strong>the</strong> teaching given by <strong>the</strong> department.<br />
26<br />
Future plans to improve <strong>the</strong> teaching given by <strong>the</strong> department include <strong>the</strong> following:<br />
• Computer-aided learning and problem-based teaching methods will be<br />
more developed.<br />
• Increasing <strong>the</strong> amount <strong>of</strong> information concerning <strong>the</strong> DNA technology, <strong>the</strong><br />
diagnosis <strong>of</strong> genetics defects and gene <strong>the</strong>rapy.<br />
• Writing an original HyperText textbook or CD-ROM during <strong>the</strong> 1-2 years about<br />
metabolism <strong>of</strong> tissues in normal situation and in <strong>the</strong> case <strong>of</strong> disorders.<br />
• Developing special tests for students on internet home page <strong>of</strong> <strong>Department</strong><br />
<strong>of</strong> Biochemistry.<br />
Education in Medical Biochemistry will be more problem-based and more integrated<br />
with <strong>the</strong> clinical specialities. Modern textbooks and o<strong>the</strong>r teaching aids<br />
allow a reduction in <strong>the</strong> number <strong>of</strong> lectures, and <strong>the</strong> quality <strong>of</strong> teaching can be<br />
fur<strong>the</strong>r improved by increasing <strong>the</strong> volume <strong>of</strong> clinically oriented, problembased<br />
seminars and group sessions.
BIOCHEMISTRY<br />
Biochemistry: resource evaluation<br />
1. Study materials<br />
- How many study books are published in your institution during last five years? 7<br />
- Do you have separate room as library in your place? Yes No<br />
- Could students borrow study books from your institution? Yes No<br />
- Do you have on-line published study materials for students? Yes No<br />
- WWW address: http://biomedicum.ut.ee/arbk/<br />
- Does University library has enough modern books in your speciality?<br />
Completely enough Enough Scarcely Absolutely scarcely No<br />
2. Amount and size <strong>of</strong> study rooms<br />
- Rooms used by Your institution only: 3 rooms with area <strong>of</strong> 100 m 2<br />
- Rooms shared with ano<strong>the</strong>r institution: 2 rooms with area <strong>of</strong> 80 m 2<br />
- Do You have enough space for study process by Your opinion?<br />
Completely enough Enough Scarce Absolutely scarcely<br />
- How <strong>the</strong> scarce <strong>of</strong> space should be handled or changed?<br />
New building Change to smaller student groups Better logistics<br />
O<strong>the</strong>r way (describe shortly)<br />
3. Current situation <strong>of</strong> study rooms<br />
- There has been repairments in last years (except Biomedicum)<br />
- How are <strong>the</strong> study rooms lightened?<br />
Very good Good Some darkness Absolutely dark for study<br />
Evaluation <strong>of</strong> general conditions:<br />
4. Your institution has<br />
Very good Good Satisfactory Bad<br />
a) 3 (how many?) auditorium(s) for workshops/seminars with 280 places, equipped with<br />
Blackboard<br />
White board & markers<br />
Screen<br />
Overhead projector<br />
Data projector<br />
Slide projector<br />
b) 2 (how many?) laboratories for practicals with 42 places, equipped with<br />
Blackboard<br />
White board and markers<br />
Screen<br />
Overhead projector<br />
Data projector<br />
Slide projection kit<br />
TV/Video projection set<br />
Computer<br />
Internet connection<br />
TV/Video projection kit<br />
Computer<br />
Internet connection<br />
5. Working rooms for teaching staff and postgraduate students:<br />
- Number <strong>of</strong> teaching staff 6<br />
- Number <strong>of</strong> rooms for staff 4<br />
- Number <strong>of</strong> individual working places 6, among <strong>the</strong>m with computers 6<br />
- Number <strong>of</strong> postgraduate students is 2<br />
- How many individual working places <strong>the</strong>y have? 2<br />
- How many computers <strong>the</strong>y have? 2<br />
6. O<strong>the</strong>r comments on resource topic (max 250 letters):<br />
27
SECTION I: APPENDIXES<br />
APPENDIX I-I<br />
Visits <strong>of</strong> <strong>the</strong> <strong>Department</strong> members to o<strong>the</strong>r institutions abroad during 1996-2000<br />
Year Researcher/Lectures Institution Country Purpose Duration<br />
1995 Joel Starkopf University <strong>of</strong> Tromso Norway Research 1 month<br />
1996 Ello Karelson University <strong>of</strong> Kiel Germany TEMPUS(Education) 1 week<br />
1996 Ello Karelson University <strong>of</strong> Stockholm Sweden TEMPUS(Education) 1 week<br />
1996 Joel Starkopf University <strong>of</strong> Tromso Norway Research 1 month<br />
1996 Mihkel Zilmer University <strong>of</strong> Stockholm Sweden TEMPUS(Education) 2 weeks<br />
1996 Mihkel Zilmer University <strong>of</strong> Kiel Germany TEMPUS(Education) 2 weeks<br />
1996 Mihkel Zilmer University <strong>of</strong> Barcelona Spain Research 1 week<br />
1996 Tiiu Vihalemm University <strong>of</strong> Barcelona Spain Research 1 week<br />
1996 Ursel Soomets University <strong>of</strong> Stockholm Sweden Research 4 weeks<br />
1997 Ceslava Kairane University <strong>of</strong> Kiel Germany TEMPUS (Education) 1 week<br />
1997 Ello Karelson Amsterdam Ne<strong>the</strong>rlands Conference 1 week<br />
1997 Joel Starkopf University <strong>of</strong> Tromso Norway Research 2 weeks<br />
1997 Tiiu Vihalemm Med Inst. Kaunas Lithuania Int. Worksop (Educ) 1 week<br />
1997 Ursel Soomets University <strong>of</strong> Stockholm Sweden Research 4 weeks<br />
1997 Ursel Soomets Nashville USA Conference 1 week<br />
1997 Ursel Soomets University <strong>of</strong> Stockholm Sweden Research 3 weeks<br />
1997 Ursel Soomets University <strong>of</strong> Stockholm Sweden Research 4 weeks<br />
1998 Ceslava Kairane Helsinki Finland Conference 1 week<br />
1998 Ello Karelson Lahti Finland Conference 1 week<br />
1998 Ello Karelson University <strong>of</strong> Stockholm Sweden Research 3 month<br />
1998 Joel Starkopf Karolinska Hospital Sweden Research 1 week<br />
1998 Kersti Zilmer Helsinki Finland Conference 1 week<br />
1998 Mihkel Zilmer Helsinki Finland Conference 2 weeks<br />
1998 Mihkel Zilmer Miami-Orlando USA Research 3 weeks<br />
1998 Mihkel Zilmer Lahti Finland Confrence 1 week<br />
1998 Tiiu Vihalemm Helsinki Finland Conference 1 week<br />
1998 Tiiu Vihalemm Lahti Finland Conference 1 week<br />
1998 Ursel Soomets University <strong>of</strong> Stockholm Sweden Research 3 weeks<br />
1998 Ursel Soomets University <strong>of</strong> Stockholm Sweden Research 2 weeks<br />
1998 Ursel Soomets Budapest Hungary Conference 1 week<br />
1998 Ursel Soomets Szeged Hungary Conference 1 week<br />
1999 Ello Karelson University <strong>of</strong> Stockholm Sweden Research 1 moth<br />
1999 Joel Starkopf Karolinska Hospital Sweden Research 1 week<br />
1999 Mihkel Zilmer University <strong>of</strong> Stockholm Sweden Research 2 weeks<br />
1999 Ursel Soomets University <strong>of</strong> Stockholm Sweden Research 4 weeks<br />
2000 Ello Karelson University <strong>of</strong> Stockholm Sweden Research 2 month<br />
2000 Joel Starkopf Karolinska Hospital Sweden Research 1 week<br />
2000 Ursel Soomets University <strong>of</strong> Stockholm Sweden Research 1 week<br />
2000 Ursel Soomets University <strong>of</strong> Stockholm Sweden Research 1 week<br />
2000 Ursel Soomets University <strong>of</strong> Stockholm Sweden Research 2 weeks<br />
2000 Ursel Soomets University <strong>of</strong> Stockholm Sweden Research 3 weeks<br />
2000 Ursel Soomets University <strong>of</strong> Stockholm Sweden Research 1 week<br />
2000 Ursel Soomets The Scripps Research Insti- USA<br />
tute<br />
Research 3 weeks<br />
28
APPENDIX I-II<br />
BIOCHEMISTRY<br />
Postgraduate students at <strong>the</strong> <strong>Department</strong> having studied abroad during 1996-2000<br />
Year <strong>Name</strong> Institution Contry Duration<br />
1995 Joel Starkopf University <strong>of</strong> Tromso Norway 1 month<br />
1996 Joel Starkopf University <strong>of</strong> Tromso Norway 2 x 2 weeks<br />
1997 Joel Starkopf University <strong>of</strong> Tromso Norway 2 weeks<br />
1997 Ursel Soomets University <strong>of</strong> Stockholm Sweden 3 month<br />
1998 Ursel Soomets University <strong>of</strong> Stockholm Sweden 1 month<br />
1999 Ursel Soomets University <strong>of</strong> Stockholm Sweden 1 month<br />
2000 Ursel Soomets University <strong>of</strong> Stockholm Sweden 3 month<br />
1996 Andres Valkna University <strong>of</strong> Stockholm Sweden 3 month<br />
1997 Andres Valkna University <strong>of</strong> Stockholm Sweden 3 month<br />
1998 Andres Valkna University <strong>of</strong> Stockholm Sweden 1 month<br />
1999 Andres Valkna University <strong>of</strong> Stockholm Sweden 1 month<br />
1996 Aune Rehema Copenhagen, Bispebjerg Hospital Denmark 3 month<br />
APPENDIX I-III<br />
Co-operation with institutions from o<strong>the</strong>r countries and participation in international<br />
research projects during 1996-2000<br />
Contact person Institution Country Aim <strong>of</strong> <strong>the</strong> collaboration<br />
Pr<strong>of</strong>. Mihkel Zilmer University <strong>of</strong> Stockholm Sweden Research and teaching<br />
Pr<strong>of</strong>. Mihkel Zilmer/<br />
Ass. Pr<strong>of</strong>. Ursel Soomets<br />
The Scripps Research Institute USA Research and innovation<br />
Pr<strong>of</strong>. Mihkel Zilmer/<br />
Sen. Ass. Joel Starkopf<br />
Pr<strong>of</strong>. Mihkel Zilmer/<br />
Sen. Ass. Joel Starkopf<br />
Pr<strong>of</strong>. Mihkel Zilmer/<br />
Sen. Ass. Joel Starkopf<br />
University <strong>of</strong> Stockholm Norway Research<br />
Karolinska Hospital Sweden Research<br />
Karolinska Hospital Sweden Research<br />
Pr<strong>of</strong>. Mihkel Zilmer SUNY at Stony Brook USA Research<br />
Pr<strong>of</strong>. Mihkel Zilmer Pensylvania State University USA Research<br />
Pr<strong>of</strong>. Mihkel Zilmer Kupio Research Institute Finland Research<br />
Pr<strong>of</strong>. Mihkel Zilmer University <strong>of</strong> Uppsala Finland Research<br />
Pr<strong>of</strong>. Mihkel Zilmer Karoliska Institut Sweden Research<br />
29
SECTION I: APPENDIXES<br />
APPENDIX I-IV<br />
Visiting lecturers at <strong>the</strong> <strong>Department</strong> during 1996-2000<br />
Visitor Institution Country Purpose <strong>of</strong> <strong>the</strong> Visit Year<br />
Ass. Pr<strong>of</strong> Ülo Langel University <strong>of</strong> Stockholm Sweden Research 1995<br />
Ass. Pr<strong>of</strong> Ülo Langel University <strong>of</strong> Stockholm Sweden Teaching 1996<br />
Ass. Pr<strong>of</strong> Ülo Langel University <strong>of</strong> Stockholm Sweden Research 1997<br />
Ass. Pr<strong>of</strong> Ülo Langel University <strong>of</strong> Stockholm Sweden Research/Teaching 1998<br />
Ass. Pr<strong>of</strong> Ülo Langel University <strong>of</strong> Stockholm Sweden Teaching (visiting pr<strong>of</strong>essor at<br />
ARBK)<br />
Ass. Pr<strong>of</strong> Ülo Langel University <strong>of</strong> Stockholm Sweden Research/Teaching (visiting pr<strong>of</strong>essor<br />
at ARBK)<br />
Pr<strong>of</strong>. Kirsti Ytrehus University <strong>of</strong> Stockholm Norway Research 1997<br />
Pr<strong>of</strong>. Jarle Vaage Karolinska Hospital Sweden Research 1998, 1999<br />
Pr<strong>of</strong>. Guro Valen Karolinska Hospital Sweden Research 2000<br />
Ass. Pr<strong>of</strong> John Robinson SUNY at Stony Brook USA Research 2000<br />
Ass. Pr<strong>of</strong>. Rebecca Corwin Pensylvania State University<br />
30<br />
1999<br />
2000<br />
USA Reseach/Teaching 2000<br />
Pr<strong>of</strong>. Rainer Rauramaa Kupio Research Institute Finland Research 2000<br />
Dr. Margus Annuk University <strong>of</strong> Uppsala Finland Research 1999, 2000<br />
Ass. Pr<strong>of</strong>. Rannar Sillard University <strong>of</strong> Stockholm Sweden Research 1996<br />
Ass. Pr<strong>of</strong>. Tommy Linne Karolinska Institute Sweden Teaching 1999, 2000<br />
APPENDIX I-V<br />
Scientific journals available at <strong>the</strong> <strong>Department</strong><br />
No <strong>Name</strong> <strong>of</strong> Journal Version<br />
1. Annals nutrition and metabolism paper, online<br />
2. Free Radical Research paper
APPENDIX I-VI<br />
Publications <strong>of</strong> <strong>the</strong> <strong>Department</strong> members during 1996-2000<br />
TEXTBOOKS, DICTIONARIES, MANUALS<br />
BIOCHEMISTRY<br />
1. Introductory Chapters <strong>of</strong> Medical Biochemistry (CD-ROM). Eds. M. Zilmer, E. Karelson. Tartu University,<br />
Dept <strong>of</strong> Biochemistry, Tartu 2001, Zilmer,M, Soomets,U,Karelson,E, Starkopf, J,<br />
Vihalemm,T, Zilmer,K,Rehema, A. (in Estonian, in press).<br />
2. Introductory Chapters <strong>of</strong> Medical Biochemistry (CD-ROM). Eds. M. Zilmer, E. Karelson. Tartu University,<br />
Dept <strong>of</strong> Biochemistry, Tartu 2001, Zilmer,M, Soomets,U,Karelson,E, Starkopf, J,<br />
Vihalemm,T, Zilmer,K, Rehema, A. (in English, in press).<br />
3. Medical Biochemistry I. Biomolecules: biochemical and clinical aspects (CD-ROM). Ed. M. Zilmer,<br />
Tartu University, Biomedicum, Tartu, 2001, Zilmer, M, Karelson, E, Vihalemm, T, Soomets, U,<br />
Starkopf, J, Zilmer, K, Rehema, A (in Estonian, in press).<br />
4. Medical Biochemistry I. Biomolecules: biochemical and clinical aspects (CD-ROM). Ed. M. Zilmer,<br />
Tartu University, Biomedicum, Tartu, 2001, Zilmer, M, Karelson, E, Vihalemm, T, Soomets, U,<br />
Starkopf, J, Zilmer, K, Rehema, A (in English, in press).<br />
5. Hundred eighty seven scientific terms in <strong>the</strong> field <strong>of</strong> food, nutrition, nutrients and cosmetics. Eds. M.<br />
Zilmer and U. Kokassaar. Tartu, Elmatar, 2000, pp.63. Zilmer, M, Kokassaar,U, Vihalemm,T (in<br />
Estonian).<br />
6. Introductory Chapters <strong>of</strong> Medical Biochemistry (CD ROM). Eds. M. Zilmer, E. Karelson. Tartu University,<br />
<strong>Department</strong> <strong>of</strong> Biochemistry, Biomedicum, Tartu 2000, Zilmer, M, Soomets, U, Karelson, E,<br />
Starkopf, J, Vihalemm, T, Zilmer, K, Rehema, A, (in Estonian).<br />
7. A hundred scientific terms (in <strong>the</strong> field <strong>of</strong> Biochemistry). Eds. M. Zilmer, Tallinn, 2000, pp.16.<br />
Zilmer, M, Kokassaar,U, Vihalemm,T (in Estonian).<br />
8. Medical Biochemistry II. Human metabolism and diseases: biochemical and medical aspects. Ed.<br />
M. Zilmer, Tartu, 1999, pp.328, Zilmer, M, Karelson, E, Vihalemm, T, (in Estonian).<br />
9. Selected chapter for medical biochemistry. Eds. U.Soomets, M.Zilmer, Tartu University Press,<br />
1998, pp.64, Karelson, E, Soomets, U, Zilmer, M, Vihalemm, T, Zilmer K, (in Estonian).<br />
10. Digestion, nutrition and diets.(2 nd edition), Tartu University Press, 1998, pp.273, Teesalu, S, Vihalemm,<br />
T. (in Estonian).<br />
11. Medical Biochemistry I. Biomolecules: biochemical and medical aspects. Ed. M. Zilmer, Tartu,<br />
1996, pp.321, Zilmer, M, Karelson, E, Vihalemm, T, (in Estonian).<br />
INTERNATIONAL TEACHING AIDS<br />
1. Introductory chapters for medical biochemistry (CD-ROM,5th edition). (Eds. U.Soomets, M. Zilmer,<br />
Biomedicum, Tartu, 2000, Soomets, U, Zilmer, M, Starkopf, J, Karelson, E, Rehema, A, Vihalemm,<br />
T, Zilmer K, Sillard, R, Langel, Ü (in English, Tartu University, Karolinska Institute, Stockholm University).<br />
2. Selected knowledge for medical biochemistry (4th edition). (Eds. U.Soomets, M. Zilmer, University<br />
<strong>of</strong> Tartu, 1999, pp.76, Soomets, U, Zilmer, M, Starkopf, J, Karelson, E, Vihalemm, T, Zilmer K, Sillard,<br />
R, Bourne, J, Langel, Ü (in English, Tartu University, Karolinska Institute, Stockholm University,<br />
Salisbury-SP4 OJR Porton Down, Med. Countermeasures, UK).<br />
3. Solid phase peptide syn<strong>the</strong>sis <strong>of</strong> glutathione and its analogs by Fmoc- and tert-Boc-Chemistry<br />
(second edition). Tartu, 1998, pp. 60, Soomets, U, Karlström, A, Zilmer, M, Langel, Ü, (in English,<br />
Tartu University, Stockholm University, Tartu University Press).<br />
4. Selected knowledge for medical biochemistry. Eds. U.Soomets, M.Zilmer, University <strong>of</strong> Tartu,<br />
1998, pp.70, Soomets, U, Starkopf, J, Zilmer, M, Karelson, E, Vihalemm, T, Valkna A, Zilmer K,<br />
Sillard, R, Bourne, J, Langel, Ü (in English, Tartu University, Karolinska Institute, Stockholm University,<br />
Salisbury-SP4 OJR Porton Down, Med. Countermeasures, UK).<br />
5. Bioorganic chemistry for medical students (second edition). Eds. U.Soomets, M.Zilmer, University<br />
<strong>of</strong> Tartu, 1997, pp.63, Soomets, U, Starkopf, J, Zilmer, M, Karelson, E, Vihalemm, T, Valkna A,<br />
Zilmer K, Sillard, R, Bourne, J, Langel, Ü (in English, Tartu University, Karolinska Institute, Stockholm<br />
University, Salisbury-SP4 OJR Porton Down, Med. Countermeasures, UK).<br />
6. Bioorganic chemistry for medical students. Eds. U.Soomets, M.Zilmer, University <strong>of</strong> Tartu, 1996,<br />
pp.65, Soomets, U, Starkopf, J, Zilmer, M, Karelson, E, Vihalemm, T, Valkna A, Zilmer K, Sillard,<br />
R, Langel, Ü (in English, Tartu University, Karolinska Institute, Stockholm University).<br />
7. Solid phase peptide syn<strong>the</strong>sis <strong>of</strong> glutathione and its analogs by Fmoc- and tert-Boc-Chemistry.<br />
Tartu, 1996, pp. 28, Valkna, A, Zilmer, M, Langel, Ü, (in English, Tartu University, Stockholm University).<br />
31
SECTION I: APPENDIXES<br />
INTERNET BOOKS AND MONOGRAPHS<br />
32<br />
Internet monograph “Impact <strong>of</strong> food”. Eds. M. Zilmer, U. Kokassaar, 1999, http://www.healthilife.ee,<br />
Kokassaar, U, Vihalemm, T, Zilmer, M. (in Estonian).<br />
OTHER SCIENTIFIC BOOKS AND MONOGRAPHS<br />
1. Vitamins – nutrients and drugs. Ed. M Zilmer, Tartu, 2001, Zilmer, M, Kokassaar, U, Vihalemm, T,<br />
Pulges, A, (in Estonian, in press)<br />
2. Drinks <strong>of</strong> family (scientific background). Ed. U. Kokassaar, M. Zilmer, Tartu, 2000, pp.,103,<br />
Vihalemm, T, Kokassaar, U, Zilmer, M, (in Estonian).<br />
3. Development <strong>of</strong> novel transport peptides and <strong>the</strong>ir application in antisence techniques. Soomets.<br />
U. (Diss. Ph.D), p.63, Stockholm, 1999.<br />
4. Interactions <strong>of</strong> galanin receptor with ligands and G-proteins: studies with syn<strong>the</strong>tic peptides.<br />
Valkna, A. (Dissertationes biologicae Universitatis Tartuensis.) p. 103. Tartu 1999.<br />
5. Modulation <strong>of</strong> adenylate cyclase activity in <strong>the</strong> rat hippocampus by neuropeptidegalanin and its<br />
chimeric analogs. Karelson, E. (Dissertationes medicinae Universitatis Tartuensis.) p. 103. Tartu<br />
1999.<br />
6. Methods <strong>of</strong> preservation <strong>of</strong> food (medical comments). Eds. U.Kokassaar, M. Zilmer, Tartu, 1999,<br />
pp.,64, Kokassaar, U, Vihalemm, T, Zilmer, M, (in Estonian).<br />
7. Oxidative stress and ischaemia-reperfusion <strong>of</strong> <strong>the</strong> heart. A clinical experimental study Starkopf, J. -<br />
(Dissertationes medicinae Universitatis Tartuensis.) p. 146. Tartu 1997.<br />
8. Vitamins. Ed. M.Zilmer, Tartu, 1996, pp.,64, Zilmer, M, Kokassaar, U, Vihalemm, T, Pulges, A, (in<br />
Estonian)<br />
9. Food- natural and artificial components. Eds. U.Kokassaar, M. Zilmer, Tartu, 1996, pp. 88, Kokassaar,<br />
U, Vihalemm, T, Zilmer, M, Pulges, A, (in Estonian).<br />
10. Food- antioxidativity, oxidative stress, preventive manipulations. Ed., M. Zilmer, Avita, Tartu, 1995,<br />
pp.71, Zilmer, M, Vihalemm, T, Kokassaar,U, (in Estonian).<br />
11. Oxidative stress and antioxidant <strong>the</strong>rapy. Ed., E.Karelson, University <strong>of</strong> Tartu,"The Estonian Pharmacist",<br />
1994,pp.168, Zilmer, M, Zilmer, K, (in Estonian).<br />
12. The Thesis "Na-pump in normal and tumorous brain tissues: structural-functional and tumorigenic<br />
aspects",University <strong>of</strong> Tartu,1991, pp.31,Zilmer, M (in English).<br />
PATENT<br />
1. Applied June 15, 2000, in Stockholm, application No. 0002232-7, by Langel, Soomets, Vasar, Zilmer,<br />
entitled “Antioxidant” application filed and owned by Vulpes.<br />
ARTICLES IN PEER REVIEWED INTERNATIONAL BOOKS<br />
1. In book The CGRP family: Calcitonin Gene-related peptide (CGRP), amylin, and adreno-medullin.<br />
Eds. D.Poyner, I.Marshall, S.D.Brain. Structure activity relationship for CGRP receptor ligands.<br />
Molecular Biology Intelligence Unit 10, Landes Bioscience, Georgetown, Texas, USA;<br />
Eurekah.com, Austin, Texas, USA. 2000, pp.25-32, Poyner, D.R., Howitt, S., Soomets, U., Langel,<br />
Ü.<br />
2. In book ”Natural antioxidants& Food Ouality in A<strong>the</strong>rosclerosis and Cancer Prevention” Eds. J. T.<br />
Kumpulainen, T. Salonen, Dietary n-3 polyunsaturated fatty acids supress reparative regeneration<br />
<strong>of</strong> <strong>the</strong> rat liver connective tissue. Published by The Royal Society <strong>of</strong> Chemistry,Thomas Graham<br />
House, UK,1996, pp.60-66,Arend,A, Zilmer,M, Zilmer, K.<br />
ARTICLES IN PEER REVIEWED INTERNATIONAL ISSUES<br />
1. Life Sciences. Pretreating rats with hyperoxia attenuates ischaemia-reperfusion injury <strong>of</strong> <strong>the</strong> heart.<br />
Tähepõld P, Valen G, Starkopf, Kairane C, Zilmer M, Vaage J., 2001, (in press).<br />
2. Patophysiology, Acute immune response in respect to exercise-induced oxidative stress. Vider, J,<br />
Lehtmaa, J, Kullisaar, T, Vihalemm, T, Zilmer, K, Kairane, C, Landõr, A, Karu, T, Zilmer, M., 2001<br />
(in press).<br />
3. Neurochemical Research. The cerebrocortical areas in normal brain aging and in Alzheimer’s disease:<br />
noticeable differences in <strong>the</strong> lipid peroxidation level and in antioxidant defence. Karelson, E,<br />
Bogdanovic, N, Garlind, A, Winblad, B, Zilmer, K, Kullisaar, T, Vihalemm, T, Kairane, C, Zilmer, M.,<br />
2001, (accepted).
BIOCHEMISTRY<br />
4. Dementia and Geriatric Cognitive Disorders. The Swedish APP670/671 Alzheimer’s Disease mutation:<br />
The first evidence for strikingly increased oxidative injury in <strong>the</strong> temporal inferior cortex. Bogdanovic,<br />
N, Zilmer, M, Zilmer, K, Rehemaa, A, Karelson, E ,2001, (accepted).<br />
5. Annals Nutrition & Metabolism. Lipoic acid prevents n-3 PUFAs induced supression <strong>of</strong> connective<br />
tissue proliferation in rat liver. Arend, A, Zilmer, M, Vihalemm,T, Sestam, G, Sepp, E., 44, 217-222,<br />
2000.<br />
6. Free Radical Research. Pretreatment with methylprednisolone protects <strong>the</strong> isolated rat heart<br />
against ischaemic and oxidative damage. Valen, G, Kawakami,T, Tähepõld,P, Starkopf, J, Kairane,<br />
C, Dumitrescu, A, Löwbeer, C, Zilmer, M, Vaage, J., 2000, 33, 31-43.<br />
7. Biochem. Biophys. Acta Deletion analogues <strong>of</strong> transportan. Soomets, U, Lindgren, M, Gallet, X,<br />
Hällbrink, M, Elmquist, A, Balaspiri, L, Zorko, M, Pooga, M, Brasseur, R. Langel, U. 2000, 1467,<br />
165-176.<br />
8. Proceedings 5 th World Congress on Trauma, Shock, Inflammation and Sepsis, Edit. E. Faist. Monduzzi<br />
Editore, Lipid peroxidation and ICU medical staff. Sipria, A, Zilmer, M, Talvik, R, Zilmer, K,<br />
Kairane, C. 2000, 413-416.<br />
9. Bioconjugate Chem Translocation properties <strong>of</strong> novel cell penetrating transportan and penetratin<br />
analogoues. Lindgren, M., Gallet, X., Soomets, U., Hällbrinm, M., Brakenhielm, E., Pooga, M.,<br />
Brasseur, R., Langel, Ü. 2000,11,619-626.<br />
10. Neuropeptides. Third intracellular loop <strong>of</strong> galanin receptor type 1 in signal transduction. Rezaei, K,<br />
Saar, K, Soomets, U, Valkna A, Schroeder, T, Näsman, J, Zorko, M, Åkermann, K, Bartfai, T, Langel,<br />
Ü, 2000, 34, 25-31.<br />
11. Brain Research. Regulation <strong>of</strong> activity <strong>of</strong> GTPase and adenylate cyclase by amyloid <br />
its fragments in rat brain tissue. Soomets U, Mahlapuu R, Jarvet J, Karelson E, Zilmer M, Zorko,<br />
M., Gräslund, A., Langel, Ü. 1999, 850,179-188.<br />
12. Proc. Natl. Acad. Sci. USA, Electrophysiological evidence for a hyperpolarizing, galanin (1-15)selective<br />
receptor on hippocampal CA3 pyramidal neurons. Xu, Z.-Q.D., Ma, X, Soomets, U,<br />
Langel, Ü, Hökfelt, T, 1999,96,14583-14587.<br />
13. Frontiers in Bioscience. Antisence properties <strong>of</strong> peptide nucleic acids. Soomets, U. Hälbrink, M,<br />
Langel, Ü, 1999,4,D782-D786.<br />
14. Cardiovascular Drugs and Therapy. Effect <strong>of</strong> low-dose aspirin on <strong>the</strong> markers <strong>of</strong> oxidative stress.<br />
Ristimäe, T, Zilmer, M, Zilmer, K, Kairane, C, Kullisaar, T, Teesalu, R, 1999, 13, 485-490.<br />
15. Acta Paediatrica. Possible oxidative stress in healthy term newborns. Metsvaht, T, Ilves, P, Talvik,<br />
T, Zilmer, K, Zilmer, M, Talvik, R, 1999, 88,1299-1300.<br />
16. Reg. Peptides. Effects <strong>of</strong> vasopressin-mastoparan chimeric peptides on insulin release and<br />
GTPase activity. Hällbrink, M., Saar, K., Östenson, C.-G., Soomets, U., Efendic, S., Howl,J.,<br />
Wheatley, M.,Zorko, M., and Langel, Ü.1999, 82 (1-3), 45-51.<br />
17. In: Peptide. Frontiers in Peptide Science, Intracellular third loop <strong>of</strong> galanin receptor as G-protein<br />
interaction site. Soomets, U. and Langel, Ü., Eds. J. P. Tam, P. T. P. Kauyama, Kluwer Academic<br />
Publishers, Dordecht, Boston, London, 1999, 662-663.<br />
18. Free Rad Res., Precondiotioning with hydrogen peroxide (H2O2) or ischemia in H2O2-induced<br />
cardiac dysfunction,1998, 29, 235-245, Valen G, Starkopf J, Takeshima S, Kullisaar T, Kengsepp<br />
A-T, Löwbeer C, Vaage J, Zilmer M.<br />
19. J Pineal Research. Comparison <strong>of</strong> <strong>the</strong> antioxidant activity <strong>of</strong> melatonin and pinoline in vitro, 1998,<br />
24, 96-101, Pähkla R, Zilmer M, Kullisaar, T, Rägo L.<br />
20. Annals <strong>of</strong> Nutrition & Metabolism. Could long-term alimentary iron overload have an impact <strong>the</strong> parameters<br />
<strong>of</strong> oxidative stress? A study on <strong>the</strong> basis <strong>of</strong> a village in South Estonia. 1998, 42, 40-43,<br />
Rehema, A, Zilmer, M, Zilmer, K, Kullisaar, T, Vihalemm, T.<br />
21. Clinical Neuroscience. Regulation <strong>of</strong> activity <strong>of</strong> GTPase and adenylate cyclase in <strong>the</strong> rat ventral<br />
hippocampus by fragments <strong>of</strong> -amyloid, 1998, 51,1,59-60. Soomets U, Mahlapuu R, Karelson E,<br />
Zilmer M, Zorko M, Langel Ü.<br />
22. Acta Odontol Scand,. Polyol-combinant saliva stimulants: a 4-month pilot study in young adults.<br />
1998, 56, 90-94, Mäkinen, K,K, Olak, J, Russak, S, Saag, M, Seedre, T, Vasar, R, Vihalemm, T,<br />
Mikelsaar, M, Mäkinen, P-L.<br />
23. Pathophysiology. Alpha-lipoic acid prevents n-3 PUFA induced supression <strong>of</strong> wound healing.<br />
1998,5,76, Arend, A, Zilmer, M, Zilmer, K.<br />
24. Pathophysiology. Remarkable differences <strong>of</strong> oxidative damage in <strong>the</strong> cortical regions from postmortem<br />
Alzheimer’s disease brain. 1998,5, 90, Karelson, E, Zilmer, K, Vihalemm, T, Kullisaar,<br />
Bogdanovic, N, Garlind, A, Winblad, B, Zilmer, M.<br />
25. Biochemistry Molecular Biology International. Activation <strong>of</strong> cAMP syn<strong>the</strong>sis in rat brain cortical<br />
membranes by rubidium and cecium ions. 1998, 45,745-751, Rosenthal, K, Lember, J, Karelson, E,<br />
Jarv, J.<br />
33
SECTION I: APPENDIXES<br />
26. Cardiovasc Res., Lipid peroxidation, arachidonic acid and products <strong>of</strong> <strong>the</strong> lipoxygenase pathway in<br />
ischemic preconditioning <strong>of</strong> rat heart,1998,37,66-75,Starkopf J, Andreasen TV, Bugge E, Ytrehus<br />
K.<br />
27. Neurobiology <strong>of</strong> Aging. Regulation <strong>of</strong> GTPase and adenylate cyclase by amyloid-b peptides,1998,<br />
19, 48. Langel, Ü., Soomets, U., Mahlapuu, R., Karelson, E., Zilmer, M., Zorko, M.<br />
28. Br J Pharmacol., Structural determinants for binding to CGRP receptors expressed by human SK-<br />
N-MC and Col 29 cells: studies with chimeric and o<strong>the</strong>r peptides.1998, 124, 1659-1666, Poyner<br />
D.R., Soomets U., Howitt S.G., Langel, Ü.<br />
29. Proceedings <strong>of</strong> 15th American Peptide Symposia. Intracellular third loop <strong>of</strong> galanin receptor as Gprotein<br />
interaction site,1998 (in press), Soomets U.,Langel Ü.<br />
30. Nature Biotechnology. Cell penetrating PNA antisense oligonucleotides modify galaninergic pain<br />
transmission in vivo. 1998, 16, 857-861. Pooga M., Hällbrink M., Soomets U., Valkna A., Saar K.,<br />
Rezaei K., Kahl U., Hao J.-X., Xu X.-J., Wiesenfeld-Hallin Z., Bartfai T. and Langel Ü.<br />
31. Arch. Biochem. Biophys. Differential regulation <strong>of</strong> GTPase activity by mastoparan and galparan.<br />
1998, 349,2, 321-328, Zorko M., Pooga M., Saar K., Rezaei K., Langel, Ü.<br />
32. J. Peptide Res. Novel galanin receptor ligands. 1998,51, 65-74, Pooga M., Juréus A., Rezaei K.,<br />
Hasanvan H., Saar K., Kask K., Kjellén P., Land T., Halonen J., Mäeorg U., Uri A., Solyom S.,<br />
Bartfai T., and Langel Ü.<br />
33. Cell Calcium. Biochemical mechanisms <strong>of</strong> calcium mobilisation induced by mastoparan and chimeric<br />
hormone-mastoparan constructs. 1998, 24, 27-34, Longland C.L, Mezna M, Langel Ü, Hällbrink<br />
M, Soomets U, Wheatley M, Michelangeli F, Howl J.<br />
34. J. Neurosci., Galanin modulation <strong>of</strong> seizures and seizure modulation <strong>of</strong> hippocampal galanin in<br />
animal models <strong>of</strong> status epilepticus. 1998,18,23,10070-7., Mazarati, A. M., Liu, H., Soomets, U.,<br />
Sankar, R., Shin, D., Katsumori, H., Langel, Ü., Wasterlain, C. G.<br />
35. Current Topics in Peptide and Protein Res. From galanin and mastoparan to galparan and transportan.<br />
1998, 2, 83-113, Soomets U., Hällbrink M., Zorko M., Langel Ü.<br />
36. Acta.Chem.Slov. Structural features <strong>of</strong> amphipathic peptides required for <strong>the</strong> activation <strong>of</strong> Gproteins.<br />
1998, 45,27-34, Bavec A., Soomets U., Langel Ü., Zorko M.<br />
37. Neuropeptides. Galaninrergic signalling and adenylate cyclase. 1998, 32, 197-210, Karelson E,<br />
Langel Ü.<br />
38. Biochemical Soc. Transactions. Review article. The role <strong>of</strong> <strong>the</strong> third cytoplasmic loop in signal<br />
transduction by galanin receptors, 1997, 25, 1036-1040, Saar, K., Valkna, A., Soomets U., Rezai,<br />
K., Zilmer, M., Langel, Ü.<br />
39. Proceedings <strong>of</strong> <strong>the</strong> 24 th Symposium <strong>of</strong> European peptide Society. Galanin receptor G-protein interaction<br />
sites as targets for drug developments. Peptides 1998: Eds. R. Ramage, R. Epton, 1997,<br />
67-70, Rezaei, K, Valkna, A., Saar, K.,Bartfai, T, Langel, Ü.<br />
40. FASEB J. Chimeric strategy for <strong>the</strong> rational design <strong>of</strong> bioactive analogs <strong>of</strong> small peptide hormones,<br />
1997,11 (7), 582-590, Howl, J., Parslow, R.A., Langel, Ü., Hawtin, S.R., Valkna, A., Yarwood, N.J.,<br />
Saar, K., and Wheatley, M.<br />
41. European Journal <strong>of</strong> Neurology. Lead-induced excessive lipid peroxidation and changes in local<br />
cerebral blood flow in rabbit brain.1997,4,390-396, Linnamägi,Ü, Zilmer,K, Zilmer, M, Kaasik,A.-E.<br />
42. Acta Neurol Scand. Changes <strong>of</strong> sympatho-adrenal and hupothalamo-pituitary-adrenocortical system<br />
in patents with head injury.1997,96,52-58, Kõiv, L, Merisalu, E, Zilmer,K, Tomberg, T, Kaasik,A.-E.<br />
43. Acta Chemica Scand., Solubilisation <strong>of</strong> Na,K-ATPase with amphiphilic peptide PD1, 1997,51,403-<br />
406, Soomets, U, Kairane, C, Zilmer, M, Langel, Ü.<br />
44. Clinica Chimica Acta. The evidence <strong>of</strong> oxidative stress in cardiac surgery and septic patients- comparative<br />
study. 1997, 262,77-88,Starkopf, J, Kokk, K, Zilmer, M, Talvik, R, Samarütel, J.<br />
45. Quintessenz. Scientific portrait <strong>of</strong> xylitol. 1997,1,24-28, Zilmer, M, Kokassaar, U.<br />
46. Cardiovasc Res. Preischemic bradykinin and ischemic preconditioning in functional and metabolic<br />
recovery <strong>of</strong> globally ischemic rat heart,1997, 33,63-70, Starkopf, J,Ytrehus, Y.<br />
47. Pharmacology & Toxicology. Antioxidative capacity <strong>of</strong> pinoline in three in vitro assay systems,<br />
1997, 80, Supplement I, p.41, Pähkla, R, Zilmer, M, Kullisaar, T, Rägo, L.<br />
48. Regulatory Peptides. A galanin-mastoparan chimeric peptide activates <strong>the</strong> Na,K-ATPase and and<br />
reverses its inhibition by ouabain,1996, 62,47-52, Langel, Ü., Pooga, M., Kairane, C., Zilmer, M.,<br />
Bartfai, T.<br />
49. J <strong>of</strong> Hypertension. Oxidative stress and hyperinsulinaemia in essential hypertension: different facets<br />
<strong>of</strong> in increased risk, 1996,14, 3,407-410, Parik, T, Allikmets, K, Teesalu, R, Zilmer, M.<br />
50. J <strong>of</strong> Human Hypertension. Effects <strong>of</strong> isradipine treatment on oxidative stress markers in patients<br />
with essential hypertension, 1996,10, 53-55, Parik, T, Allikmets, K, Zilmer, K, Vihalemm, T, Kullisaar,<br />
Teesalu, R, Zilmer, M.<br />
34
BIOCHEMISTRY<br />
51. J Cardiovascular risk. Evidence for oxidative stress in essential hypertension: perspective for antioxidant<br />
<strong>the</strong>rapy, 1996,3,49-53, Parik, T, Allikmets, K, Teesalu, R, Zilmer, M.<br />
52. Meth Find Exp Clin Pharmacol. Autoradiographic localization <strong>of</strong> [3H] pinoline binding sites in<br />
mouse tissues, 1996,18, 359-366, Pähkla, R, Masso, R, Zilmer, M, Rägo, L, Airaksen, M, M.<br />
53. Acta Medica Baltica. Effects <strong>of</strong> nifedipine treatment on oxidative stress markers in hypertensive patients,<br />
1996, 3(2), 140-144, Parik, T, Allikmets,K, Teesalu,R, Zilmer, M.<br />
54. Acta Pediatrica. Markers <strong>of</strong> oxidative stress before and after exchange transfusion for neonatal<br />
sepsis,1996, 85,10,1244-1246, Kokk T,Talvik,R, Zilmer,M, Kütt,E, Talvik,T.<br />
55. Neurochemistry. Investigations <strong>of</strong> some natural peptides and <strong>the</strong>ir syn<strong>the</strong>tic derivatives using brain<br />
Na,K-ATPase, 1996, 13, 3, 223-227, Kairane, C, Tähepõld, L, Langel, Ü, Sillard, R, Zilmer, M. (in<br />
Russian).<br />
56. Scandinavian J Rheumatology. Nutrition in Prevention <strong>of</strong> Osteoporosis. 1996, 25,81-82, Teesalu,<br />
S, Vihalemm, T, Vaasa, I-O.<br />
57. 5 articles are submitted in 2001.<br />
ARTICLES IN ANOTHER PEER REVIEWED ISSUES<br />
1. Estonian Pharmacist. Alcohol. 2000,1,15-20, Kokassaar, U, Vihalemm, T, Zilmer, M. (in Estonia).<br />
2. Scandinavian J <strong>of</strong> Nutrition. The consumption <strong>of</strong> goat’s milk yoghurt fermented with special lactobacillus<br />
strains may improve <strong>the</strong> human antioxidative status. 2000, 44, (Supplement 37), S94,<br />
Songisepp, E, Kullisaar, T, Zilmer, K, Mikelsaar, M, Zilmer,M.<br />
3. Estonian Pharmacist. Bouillon (scientific background). 1999,4, 14-17, Kokassaar, U, Vihalemm, T,<br />
Zilmer, M. (in Estonia).<br />
4. Estonian Pharmacist. Juice, nectar, juice beverage (scientific background).1999,3, 8-11, Vihalemm,<br />
T, Kokassaar, U, Zilmer, M. (in Estonia).<br />
5. Estonian Pharmacist. Mineral water. 1999,2,16-20, Vihalemm, T, Kokassaar, U, Zilmer, M. (in<br />
Estonia).<br />
6. Estonian Pharmacist. Tea (Scientific background).1999,1,11-16, Kokassaar, U, Vihalemm, T, Zilmer,<br />
M. (in Estonia).<br />
7. Estonian Parmacist. Cacao (Scientific background).1998,4,13-18, Kokassaar, U, Vihalemm, T, Zilmer,<br />
M. (in Estonia).<br />
8. Estonian Parmacist. C<strong>of</strong>fee (Scientific background).1998,3, 11-15, Vihalemm, T, Kokassaar, U,<br />
Zilmer, M. (in Estonia).<br />
9. Estonian Parmacist. Scientific background <strong>of</strong> popularity <strong>of</strong> fermented milk products. 1998,1, 16-20,<br />
Vihalemm, T, Kokassaar, U, Zilmer, M. (in Estonia).<br />
10. Estonian Pharmacist. Could long-lasting alimentary iron overload have an impct on <strong>the</strong> parameters<br />
<strong>of</strong> oxidative stress? 1997, 54-55, Rehema, A, Zilmer, K, Vihalemm, T, Kullisaar, T, Zilmer, M. (in<br />
Estonian).<br />
11. Estonian Pharmacist. Oxidative stress and damages <strong>of</strong> heart: possible preventive manipulations <strong>of</strong><br />
myocard. 1997,67-68, Starrkopf, J. Valen, G, Vihalemm, T, Kullisaar, T, Kengsepp, A.-T. Kairane,<br />
C, Zilmer, K, Zilmer, M. (in Estonian).<br />
12. Estonian Pharmacist. Testing <strong>of</strong> antioxidative capacity <strong>of</strong> saliva in healthy and parodontosis. 1997,<br />
24-25, Kullisaar, T, Kengsepp, A.-T, Saag, M, Maksimov, S, Vihalemm, T, Zilmer, M. (in Estonian).<br />
13. Estonian Pharmacist. Pinoline and melatonin: potent antioxidants. 1997, 47-48, Pähkla, R, Zilmer,<br />
M, Kullisaar, T, Rägo, L. (in Estonian).<br />
14. Estonian Physician. Effect <strong>of</strong> isradipine on oxidative stress, 1997, (Supplement) 41-42, Parik, T.,<br />
Allikmets, K., Teesalu, R., Zilmer M (in Estonian).<br />
15. Estonian Parmacist. Milk. 1997,4, 15-18, Vihalemm, T, Kokassaar, U, Zilmer, M. (in Estonia).<br />
16. Estonian Parmacist. Hirudo<strong>the</strong>rapy in <strong>the</strong> past and future. 1997,2, 10-14, Kokassaar, U, Zilmer, M.<br />
(in Estonia).<br />
17. Estonian Pharmacist. Food, nutrition and nutrients. VII, Food additives. 1997,1,13-16, Kokassaar,<br />
U, Vihalemm, T, Zilmer, M, (in Estonian).<br />
18. Estonian Pharmacist. Food, nutrition and nutrients. VI, Water. 1996,3,17-21, Kokassaar, U, Vihalemm,<br />
T, Zilmer, M, (in Estonian).<br />
19. Estonian Pharmacist. Chimeric peptides as basic molecules for disaining new drugs, 1996, 3, 8-10,<br />
Laidmäe, E, Karelson, E, Hindrikus, T, Zilmer, M, (in Estonian).<br />
20. Estonian Pharmacist. Food, nutrition and nutrients. Vb, Bioelements in our food (II). 1996, 2,21-26,<br />
Kokassaar, U, Vihalemm, T, Zilmer, M, (in Estonian).<br />
21. Estonian Pharmacist. Food, nutrition and nutrients. Va, Bioelements in our food (I). 1996, 1,11-16,<br />
Kokassaar, U, Vihalemm, T, Zilmer, M, (in Estonian).<br />
22. Scient.Conf. “17th Estonian Chemistry Days”, Tartu, Dependence <strong>of</strong> brain adenylate cyclase activity<br />
on concentration <strong>of</strong> Rb + ja Cs + .1996,173-174. Rosenthal, K, Lember J, Karelson E.<br />
35
SECTION I: APPENDIXES<br />
36
APPENDIX I-VII<br />
Academic and administrative personnel: <strong>Department</strong> <strong>of</strong> Biochemistry<br />
BIOCHEMISTRY<br />
<strong>Name</strong> Title Load Area Gender Birth year Scientific degree Year <strong>of</strong> commencement Labour time (y)<br />
1. Mihkel Zilmer Pr<strong>of</strong>essor 1,00 Medical biochemistry Male 1948 Ph.D, Dr.Med 1975 & 1992 29<br />
2. Ello Karelson Docent 1,00 Medical biochemistry Female 1946 Ph.D, Dr.Med 1978 & 1999 22<br />
3. Tiiu Vihalemm Docent 1,00 General Biochemistry Female 1940 Ph.D 1970 36<br />
4. Czeslawa Kairane Lecturer 1,00 Medical biochemistry Female 1949 Ph.D 1975 15<br />
5. Ursel Soomets Docent 0,50 General Biochemistry Male 1962 Ph.D 2000 15<br />
6. Joel Strakopf Lecturer 0,50 Medical biochemistry Male 1966 Dr.Med 1997 7<br />
7. Kersti Zilmer Lecturer 0,50 Medical biochemistry Female 1948 Ph.D 1978 26<br />
8. Hell Alapuu Technical staff 1,00 Female 1941 32<br />
9. Anu Tüür Technical staff 1,00 Female 1945 31<br />
10. Rita Mõttus Preparator 1,00 Female 1948 26<br />
37
APPENDIX I-VIII<br />
Curriculum Vitae <strong>of</strong> <strong>the</strong> staff<br />
BIOCHEMISTRY<br />
ZILMER, MIHKEL Date <strong>of</strong> birth: 15/12/1948 Gender:male Citizenship:Estonian Address:Puusepa 37, Tartu,<br />
50406, Estonia Educational history: 1966-1971 Tartu University, Academic degrees (with year and university):<br />
1976 Ph.D (Biochemistry, Tartu University), 1992Doctor <strong>of</strong> Medical Sciences (Tartu University Employment and<br />
pr<strong>of</strong>essional experience: 1966-1971 Tartu University, Estonia, 1971-1976 Postgraduate research, Faculty <strong>of</strong><br />
Medicine, TU, 1976 - Ph.D. (Biochemistry), 1992 Associate pr<strong>of</strong>essor, Dpt. Biohemistry, Faculty <strong>of</strong> Medicine,TU,<br />
1992 Dr. <strong>of</strong> Medical Sciences (in Biochemistry), 1992-1997 Pr<strong>of</strong>. <strong>of</strong> General Biochemistry, TU 1994-now Head <strong>of</strong><br />
<strong>the</strong> Dpt. Biochemistry, Faculty <strong>of</strong> Medicine,TU, 1996-now, Expert/referee <strong>of</strong> Estonian Drug Administration,1997now<br />
Pr<strong>of</strong>essor <strong>of</strong> Medical Biochemistry, Dpt. Biochemistry, Faculty <strong>of</strong> Medicine,TU Administrative experience:<br />
1978-1980 Assistant <strong>of</strong> prodean; 1994-now Head <strong>of</strong> <strong>the</strong> Dpt. Biochemistry, Faculty <strong>of</strong> Medicine,TU, Referee <strong>of</strong><br />
Estonian Science Foundation (for Estonian, Finnish, Russian grants), 1996-now, Referee/expert <strong>of</strong> Estonian Drug<br />
Administration, in <strong>the</strong> field <strong>of</strong> vitamins, minerals, antioxidants, The author for Estonian Encyclopedia, 1997-now.<br />
Co-ordinator <strong>of</strong> investigations in <strong>the</strong> field <strong>of</strong> oxidative stress in Estonia, 1996-1998, Expert <strong>of</strong> investigations in <strong>the</strong><br />
field <strong>of</strong> biosensors for narcotics (project: Stockholm University - Dept <strong>of</strong> Biochemistry, TU) Honours and awards:<br />
Highest prize <strong>of</strong> Estonian Republic (in <strong>the</strong> field innovation, in 1999), highest scientific prize <strong>of</strong> Estonian Republic<br />
(in <strong>the</strong> field <strong>of</strong> medicine, in 1998). Highest prize (medal) <strong>of</strong> Faculty <strong>of</strong> Medicine, TU in <strong>the</strong> field <strong>of</strong> science and<br />
teaching (in 1997). First prize (in 1997) <strong>of</strong> Faculty <strong>of</strong> Medicine and TU for original textbook “Medical Biochemistry<br />
I. Biomolecules: biochemical and medical aspects”. Membership in academic and scientific societies: International<br />
Union <strong>of</strong> Biochemistry; International scientific organization “Society <strong>of</strong> Free Radicals Research”. Current<br />
research program and grants: Research field: Molecular medicine in <strong>the</strong> field <strong>of</strong> neurochemistry (regulation <strong>of</strong><br />
sodium pump and Na/H-exchanger, chimeric peptides) and oxidative stress (determination, role and prevention in<br />
essential hypertension, cardiopulmonary bypass, sepsis a<strong>the</strong>rosclerosis; antioxidativity <strong>of</strong> drugs). Two grants from<br />
<strong>the</strong> Estonian Science Foundation, 1995-1997 "Ischemia/reperfusion damages: screening and pre- and postoperative<br />
prevention”, 1998-2001 Impro-vement <strong>of</strong> outcome after drug-treatment, balloon angioplasty and thrombolytic<br />
<strong>the</strong>rapy in patients with cardiomyopathy and myocardial ischaemia via regulation <strong>of</strong> oxidative stress and antioxidant<br />
treatment (adenosine, ACE-inhibitors, etc.). Three grants from Estonian Innovation Fond, 1996, 1997 and<br />
1999, “Investigation and production <strong>of</strong> bioactive peptides” (co-operation with Stockholm University). 1998-2000<br />
Member and co-head <strong>of</strong> International Research Project “KIRT” (between Karolinska Institute and TU). Grant from<br />
The James S. McDonell Foundation (1999-2001) “Neuropeptide receptor signal transduction as a target for drug<br />
development for <strong>the</strong> treatment <strong>of</strong> cognitive disorders”. Patent: Applied June 15, 2000, in Stockholm, application<br />
No. 0002232-7, by Langel, Soomets, Vasar, Zilmer, entitled “Antioxidant” application filed and owned by Vulpes.<br />
Supervision <strong>of</strong> dissertations: 8 Master Theses and Doctoral Dissertations Supervised Publications: 225 publications,<br />
including 9 monographs and 58 full length articles and reviews in peer reviewed international journals.<br />
Also 17 textbooks (3 international) published.<br />
STARKOPF, JOEL Date <strong>of</strong> birth: 08/02/1966 Gender: male Citizenship: Estonian Address: Ravila 56 – 9, 50408,<br />
Tartu, Estonia Educational history: Tallinn, Secondary School no. 43 Faculty <strong>of</strong> Medicine, University <strong>of</strong> Tartu<br />
(M.D.) internship in anaes<strong>the</strong>siology reseaerch-fellow (Ph.D) Academic degrees (with year and university):<br />
medical doctor (MD, University <strong>of</strong> Tartu) doctor <strong>of</strong> medical sciences (PhD, University <strong>of</strong> Tartu) Employment and<br />
pr<strong>of</strong>essional experience: Tartu University Hospital, department <strong>of</strong> cardiac surgery, anaes<strong>the</strong>siologist, ¼ position;<br />
Tartu University Clinics, department <strong>of</strong> anaes<strong>the</strong>siology, anaes<strong>the</strong>siologist, ½ position; University <strong>of</strong> Tartu,<br />
department <strong>of</strong> biochemistry, assistant ½ position, University <strong>of</strong> Tartu, department <strong>of</strong> biochemistry, senior assistant<br />
½ position; Tartu University Clinics, clinic <strong>of</strong> anaes<strong>the</strong>siology and intensive care, assistant ½ position Administrative<br />
experience: none Honours and awards: none Membership in academic and scientific societies: board<br />
member <strong>of</strong> <strong>the</strong> Estonian Society <strong>of</strong> Anaes<strong>the</strong>siologists Current research program and grants: Research field:<br />
ischaemia-reperfusion injury <strong>of</strong> <strong>the</strong> heart with special interest on <strong>the</strong> role <strong>of</strong> oxidative stress and strategies for<br />
myocardial protection. Effects <strong>of</strong> hyperoxia on subsequent myocardial ischaemic damage. No personal grants<br />
hold at present moment. Supervision <strong>of</strong> dissertations: P. Tähepõld, masters degree, commenced in Karolinska<br />
Hospital, Sweden, Dec. 2000. Publications: 37 publications, including 1 monograph and 8 full length papers in<br />
peer reviewed journals.<br />
SOOMETS, URSEL Date <strong>of</strong> birth: July 18 th , 1962 Gender: male Citizenship: Estonian Address: Puiestee 75A,<br />
51009 Tartu, Estonia Educational history: 1969 – 1977Viljandi, Secondary School no.5, 1977 – 1980 Viljandi,<br />
secondary School no.1; 1980 – 1985Faculty <strong>of</strong> Chemistry and Physics, <strong>Department</strong> <strong>of</strong> Chemistry, Tartu State<br />
University; 1987 – 1990post-graduate studentship at <strong>the</strong> <strong>Department</strong> <strong>of</strong> Organic Chemistry <strong>of</strong> Tartu State University;<br />
1996 – 2000Ph.D. courses in <strong>Department</strong> <strong>of</strong> Biochemistry, Faculty <strong>of</strong> Medicine, University <strong>of</strong> Tartu Academic<br />
degrees (with year and university): 2000PhD in neurochemistry, Stockholm University, Sweden;<br />
1994Master <strong>of</strong> Sciences (chemistry), University <strong>of</strong> Tartu, Estonia Employment and pr<strong>of</strong>essional experience:<br />
1985 – 1987 research fellow, <strong>Department</strong> <strong>of</strong> Organic Chemistry, University <strong>of</strong> Tartu, Estonia; 1987 engineer,<br />
Laboratory <strong>of</strong> Bioorganic Chemistry, University <strong>of</strong> Tartu, Estonia; 1987 – 1990 post-graduate studentship, <strong>Department</strong><br />
<strong>of</strong> Organic Chemistry, University <strong>of</strong> Tartu, Estonia; 1991 senior engineer, Laboratory <strong>of</strong> Enzymology,<br />
University <strong>of</strong> Tartu, Estonia; 1991 – 2000 senior lecturer, <strong>Department</strong> <strong>of</strong> Biochemistry, Faculty <strong>of</strong> Medicine, University<br />
<strong>of</strong> Tartu, Estonia; 2000 - ½ associate pr<strong>of</strong>essor; ½ senior researcher, <strong>Department</strong> <strong>of</strong> Biochemistry, Faculty<br />
<strong>of</strong> Medicine, University <strong>of</strong> Tartu, Estonia Administrative experience: none Honours and awards: none Member-<br />
39
SECTION I: APPENDIXES<br />
ship in academic and scientific societies: member <strong>of</strong> Estonian Biochemical Society Current research program<br />
and grants: Antisense studies <strong>of</strong> neuropeptide receptors, syn<strong>the</strong>sis and characterisation <strong>of</strong> novel antioxidants,<br />
studies <strong>of</strong> signal transduction <strong>of</strong> neuropeptides. Supervision <strong>of</strong> dissertations: none Publications: 42 – 1<br />
monograph, 23 scientific articles, 10 abstracts <strong>of</strong> conferences, 8 teaching aids<br />
KARELSON, ELLO-RAHEL Date <strong>of</strong> birth: August 6 th , 1946 Gender: Mrs. Citizenship: Estonian Address: <strong>Department</strong><br />
<strong>of</strong> Biochemistry, Tartu University, Ravila Str.19, 50411 Tartu Educational history: Faculty <strong>of</strong> Medicine,<br />
Tartu University; Post-graduate research course (correspondence) in biological chemistry, <strong>Department</strong> <strong>of</strong> . Biochemistry,<br />
Tartu University Academic degrees (with year and university): Ph.D. (pharmacology), 1977, Tartu<br />
University; M.D. 1999, Tartu University Employment and pr<strong>of</strong>essional experience: Research assistant and<br />
postgraduate student, Laboratory <strong>of</strong> Enzymology , Tartu University; Junior research fellow, Laboratory <strong>of</strong> Enzymology,<br />
Medical Faculty, Tartu University; Senior assistant, <strong>Department</strong> <strong>of</strong> Biochemistry, Medical Faculty, Tartu<br />
University ; Associate Pr<strong>of</strong>essor, <strong>Department</strong> <strong>of</strong> Biochemistry, Medical Faculty, Tartu University Administrative<br />
experience: Curator <strong>of</strong> Chair <strong>of</strong> Medical Biochemistry, Medical Faculty, Tartu University Honours and awards: −<br />
Membership in academic and scientific societies: Estonian Biochemical Society Current research program<br />
and grants: Grant from <strong>the</strong> Estonian Scientific Foundation: Study <strong>of</strong> <strong>the</strong> functional interactions between oxidative<br />
stress and neuropeptide galanin in <strong>the</strong> postmortem brain tissue from patients with Alzheimer’s disease Supervision<br />
<strong>of</strong> dissertations: 4 Master <strong>the</strong>sis Publications: 78 scientific publications (including 15 full articles in peerreviewed<br />
international journals). Also 6 textbooks is published.<br />
VIHALEMM, TIIU Date <strong>of</strong> birth: 1940-04-13 Gender:female Citizenship:Estonian Address:Vanemuise 64-24,<br />
50410 Tartu Educational history:Faculty <strong>of</strong> Physics and Chemistry, University <strong>of</strong> Tartu 1963 Academic degrees<br />
(with year and university): Cand. sci 1970, University <strong>of</strong> Tartu Employment and pr<strong>of</strong>essional experience: 36<br />
years Administrative experience: none Honours and awards: none Membership in academic and scientific<br />
societies: FEBS Current research program and grants:(Scientific projects <strong>of</strong> Health Promotion in Estonia<br />
1997, 1998, 2000 Supervision <strong>of</strong> dissertations: Co-supervisor <strong>of</strong> 1 dissertation Ph.D Publications: 51articles<br />
(16 articles in peer reviewed international issues; 22 articles in ano<strong>the</strong>r peer reviewed issues, 13 ano<strong>the</strong>r scientific<br />
articles). Also 5 textbooks published.<br />
KAIRANE, CESLAVA Date <strong>of</strong> birth: 01 .01. 1950. Gender: Female Citizenship: Estonian Address: Sirbi 22, Tartu<br />
Educational history: Medical Institut <strong>of</strong> Riga, 1973. Academic degrees (with year and university): Ph.D, 1983,<br />
Institute <strong>of</strong> Chemical Physics <strong>of</strong> Acad. Sci. <strong>of</strong> USSR (Moscow). Employment and pr<strong>of</strong>essional experience: 15<br />
years Administrative experience: - Honours and awards: - Membership in academic and scientific societies:<br />
- Current research program and grants: influence <strong>of</strong> <strong>the</strong> oxidative stress on <strong>the</strong> activity <strong>of</strong> different enzymes.<br />
(Scientific Projects <strong>of</strong> Health Promotion in Estonia 1997, 1998, 2000.) Supervision <strong>of</strong> dissertations: 2 <strong>the</strong>ses <strong>of</strong><br />
bachelor Publications: 41<br />
ZILMER, KERSTI Date <strong>of</strong> birth: June 5 th 1948 Gender: female Citizenship: Estonian Address: Puusepa 37 Tartu<br />
50406 Educational history: University <strong>of</strong> Tartu, Special program in <strong>the</strong> field <strong>of</strong> biochemistry, 1971 Academic<br />
degrees (with year and university): Ph. D. , Tartu University, 1986 Employment and pr<strong>of</strong>essional experience:<br />
29 years Administrative experience: Honours and awards: Membership in academic and scientific societies:<br />
Member in The European Society <strong>of</strong> Biochemistry Current research program and grants: oxidative stress<br />
(determination, role and prevention in <strong>the</strong> case <strong>of</strong> a<strong>the</strong>rosclerosis, iron-overloading; screening <strong>of</strong> antioxidative<br />
properties <strong>of</strong> medicines); performer <strong>of</strong> 2 grants <strong>of</strong> <strong>the</strong> Estonian Scientific Foundation Supervision <strong>of</strong> dissertations:<br />
5 <strong>the</strong>ses <strong>of</strong> bachelor in pharmacy Publications: 47 articles (total number <strong>of</strong> publications –166). Also 2<br />
textbooks are published.<br />
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PHARMACOLOGY<br />
<strong>Name</strong> <strong>of</strong> <strong>the</strong> <strong>Department</strong>: <strong>Department</strong> <strong>of</strong> Pharmacology<br />
Head <strong>of</strong> <strong>the</strong> <strong>Department</strong>: Pr<strong>of</strong>essor Lembit Allikmets<br />
<strong>Name</strong> <strong>of</strong> <strong>the</strong> Chair: Pharmacology<br />
Head <strong>of</strong> <strong>the</strong> Chair: Pr<strong>of</strong>essor Lembit Allikmets<br />
<strong>Name</strong> <strong>of</strong> <strong>the</strong> Chair: Pharmaco<strong>the</strong>rapy and Toxicology<br />
Head <strong>of</strong> <strong>the</strong> Chair: Pr<strong>of</strong>essor Alexander Zharkovsky<br />
<strong>Name</strong> <strong>of</strong> <strong>the</strong> Chair: Clinical Pharmacology<br />
Head <strong>of</strong> <strong>the</strong> Chair: Docent Rein Pähkla<br />
Subject codes: ARFR.01.023; ARFR.01.029; ARFR.01.030<br />
ARFR.01.031; ARFR.01.034, ARFR.02.012<br />
ARFR.02.016; ARFR.03.007; ARFR.03.009<br />
ARFR.03.010; ARFR.03.011<br />
I. CONTENT OF THE TEACHING<br />
1. How have <strong>the</strong> aims and objectives described in your curriculum changed<br />
during <strong>the</strong> last five years?<br />
In basic pharmacology (3 rd year students) <strong>the</strong> molecular and cellular basis <strong>of</strong><br />
drug action and pharmacokinetics have become a central part <strong>of</strong> <strong>the</strong> curriculum<br />
in pharmacology and toxicology. The characterisation <strong>of</strong> individual drugs<br />
(pharmaceutical preparations) is based on <strong>the</strong> recent important advances in<br />
<strong>the</strong> molecular biology <strong>of</strong> receptors, enzymes, transporters and o<strong>the</strong>r target<br />
molecules for drug action. It has become increasingly important for practising<br />
physicians to understand <strong>the</strong> basic principles <strong>of</strong> cellular communication and<br />
drug-receptor interactions. Our curriculum aims to provide <strong>the</strong> students with a<br />
conceptual framework on which <strong>the</strong>y can build knowledge <strong>of</strong> individual drugs,<br />
drug groups and on which <strong>the</strong>y can also later add information about future<br />
<strong>the</strong>rapeutic agents. In addition, target-based rational drug design is presented<br />
as a new approach to <strong>the</strong> development <strong>of</strong> <strong>the</strong>rapeutic agents. Pharmacokinetics,<br />
toxicology, immunopharmaology and chemo<strong>the</strong>rapy <strong>of</strong> viral diseases have<br />
become increasingly important parts <strong>of</strong> <strong>the</strong> curriculum. All <strong>the</strong> students get in<br />
<strong>the</strong> beginning <strong>of</strong> study year exact program <strong>of</strong> teaching and several o<strong>the</strong>r<br />
teaching aids, prepared by department members.<br />
Drug toxicology course is given to <strong>the</strong> medical students during <strong>the</strong> third year<br />
and consists <strong>of</strong> two parts: mandatory course (8 hours <strong>of</strong> problem-oriented and<br />
integrated lectures, and 4 hours <strong>of</strong> <strong>the</strong> seminars) and two optional courses:<br />
<strong>the</strong>oretical (10 hours <strong>of</strong> lectures and 12 hours <strong>of</strong> seminars) and practical one<br />
(30 hours <strong>of</strong> experimental work and seminars). The drug toxicology course is<br />
fully based on <strong>the</strong> acquired knowledge from basic pharmacology course and<br />
integrated with <strong>the</strong> basic knowledge <strong>of</strong> pharmacology and related disciplines<br />
such as pathology and biochemistry. The different principles in mandatory and<br />
optional courses are used. Mandatory course is based on <strong>the</strong> traditional ap-<br />
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SECTION I: SELF-EVALUATION<br />
42<br />
proach and given in form <strong>of</strong> lectures. Seminar work is built up on <strong>the</strong> <strong>the</strong> principle<br />
<strong>of</strong> problem-based teaching. During <strong>the</strong> past three years a slow transition<br />
from traditional teaching toward integrated and problem based teaching has<br />
occurred. Each principle however has its own advantages and disadvantages.<br />
The validation <strong>of</strong> principle <strong>of</strong> teaching is based on <strong>the</strong> specific aims and objectives<br />
to be achieved.<br />
The main aims <strong>of</strong> <strong>the</strong> mandatory course <strong>of</strong> drug toxicology are as follows.<br />
• Provide students with an understanding <strong>of</strong> <strong>the</strong> mechanisms how pharmacodynamic<br />
and pharmacokinetic properties <strong>of</strong> <strong>the</strong> drug might be transformed<br />
into its toxic action.<br />
• To enable medical students to apprise <strong>the</strong> risks <strong>of</strong> pharmaceuticals and too<br />
enable graduate to review critically his or her own <strong>the</strong>rapeutic decisions in<br />
relation to hazardous side effects.<br />
The objectives <strong>of</strong> <strong>the</strong> mandatory course are:<br />
• to provide basic working knowledge on <strong>the</strong> principles <strong>of</strong> toxic drug actions<br />
• mechanisms <strong>of</strong> acute poisoning and principles <strong>of</strong> detoxication<br />
• understanding <strong>of</strong> <strong>the</strong> problem" drug -induced disease"<br />
• basic knowledge on <strong>the</strong> problems related to trhug abuse, genotoxicity, cancerogenity<br />
and teratogenity.<br />
The control <strong>of</strong> knowledge is integrated in <strong>the</strong> final examination in pharmacology.<br />
The optional <strong>the</strong>oretical course is related to <strong>the</strong> scientific expertise and research<br />
interests <strong>of</strong> teaching staff and based on <strong>the</strong> integration with o<strong>the</strong>r disciplines<br />
like cell- and molecular biology, biochemistry, pathology. Students are<br />
given primary knowledge on <strong>the</strong> clinical aspects drug-induced disturbances <strong>of</strong><br />
<strong>the</strong> central nervous system. The major objectives <strong>of</strong> this course is provide students<br />
with working knowledge <strong>of</strong> <strong>the</strong> mechanisms <strong>of</strong> toxic action on <strong>the</strong> nervous<br />
system, rise <strong>the</strong> interest toward research problems in drug toxicology and<br />
finally develop way <strong>of</strong> thinking which is based on <strong>the</strong> scientific facts. During<br />
this course student should essay about 20 min using scientific publications,<br />
promote discussion on <strong>the</strong> related topic and answer <strong>the</strong> questions. A part <strong>of</strong><br />
this course is devoted to <strong>the</strong> methodological aspects <strong>of</strong> drug toxicology. For<br />
example, students get knowledge on <strong>the</strong> methods <strong>of</strong> assessing toxicity on <strong>the</strong><br />
primary neuronal cultures, principles <strong>of</strong> use <strong>of</strong> laser confocal microscopy, principles<br />
<strong>of</strong> assessment <strong>of</strong> apoptosis and necrosis, priniciples <strong>of</strong> <strong>the</strong> study <strong>of</strong> drug<br />
abuse and drug reinforcement etc The practical demonstrations how primary<br />
culture is prepared how <strong>the</strong> confocal microscope is used etc are essential<br />
parts <strong>of</strong> this course.<br />
The practical optional course in drug toxicology is fully built up on <strong>the</strong> problem-solving<br />
methodology. During this course groups <strong>of</strong> students are given a<br />
task to solve a problem while <strong>the</strong>y are working in <strong>the</strong> lab. For example: problem<br />
: we have to find <strong>the</strong> toxic concentration <strong>of</strong> glutamate on <strong>the</strong> primary culture<br />
<strong>of</strong> <strong>the</strong> cerebellar granule cells. To do that students have to develop <strong>of</strong> <strong>the</strong><br />
plan <strong>of</strong> experiment, perform experiment, analyse data.. Ano<strong>the</strong>r example: students<br />
have to test <strong>the</strong> mechanisms <strong>of</strong> toxicity <strong>of</strong> cytosine arabinoside on <strong>the</strong><br />
cell line GT1-7 overexpressing Bcl-2 gene. To do that students have to detect
PHARMACOLOGY<br />
apoptosis and necrosis etc At <strong>the</strong> end <strong>of</strong> this work students have to prepare<br />
presentation on <strong>the</strong> results obtained and promote discussions on this or related<br />
topic.<br />
The major objectives <strong>of</strong> this course are to train students in teamwork within<br />
research environment, to improve interpersonal and communication skills and<br />
give some training in peer assessment. To give students insight into range <strong>of</strong><br />
pre-clinical methods used in <strong>the</strong> assessment <strong>of</strong> drug toxicity. During <strong>the</strong><br />
courses in drug toxicology <strong>the</strong> students are provided with additional teaching<br />
material in a form <strong>of</strong> syllabus, which always available on-line from <strong>the</strong> internet<br />
Our experience shows that practical course is very important part <strong>of</strong> <strong>the</strong><br />
teaching process and probably <strong>the</strong> most effective.<br />
In teaching clinical pharmacology to <strong>the</strong> 6th year medical students <strong>the</strong> main<br />
aim is now to provide <strong>the</strong> students with an understanding <strong>of</strong> individual patients’<br />
characteristics influencing <strong>the</strong> <strong>the</strong>rapeutic efficacy and side effects <strong>of</strong> drugs.<br />
Genetic, environmental and o<strong>the</strong>r influences may affect both drug and side<br />
effects <strong>of</strong> drug action in a critical manner. Doctors should try to take <strong>the</strong>se<br />
factors into account in treating individual patients. The curriculum has been<br />
changed accordingly; <strong>the</strong> teaching is now largely disease-oriented and problem-based.<br />
Ano<strong>the</strong>r aim is to teach critical evaluation <strong>of</strong> existing fashions and<br />
new <strong>the</strong>rapies. This includes both critical evaluations <strong>of</strong> published clinical<br />
studies and pharmaceutical marketing information, and self-evaluation <strong>of</strong> a<br />
physician’s or clinic’s <strong>the</strong>rapeutic practices. During semester <strong>the</strong> students go<br />
through several written tests and final exam is oral.<br />
2. Describe <strong>the</strong> strengths and weaknesses <strong>of</strong> <strong>the</strong> teaching in your department.<br />
Strengths<br />
Basic and clinical pharamcology and toxicology used to be two separate<br />
courses taught by two separate chairs in <strong>the</strong> same department until 1999. This<br />
caused some unnecessary overlap and problems in co-ordination between <strong>the</strong><br />
courses. This has been changed now. A strength <strong>of</strong> <strong>the</strong> current system is that<br />
each topic and subject area can now be covered in a co-ordinated manner<br />
from <strong>the</strong> molecular basis <strong>of</strong> drug action to clinical practice. Also <strong>the</strong> teachers’<br />
individual skills and expertise can now be utilised in a more efficient manner.<br />
The research program <strong>of</strong> <strong>the</strong> department is not centred on a single <strong>the</strong>me,<br />
and is actually quite broad for <strong>the</strong> small size <strong>of</strong> <strong>the</strong> teaching and research staff.<br />
While this may be a limiting factor for excellence in research, it provides a<br />
broader base <strong>of</strong> experience and expertise to be employed for specific teaching<br />
assignments. Research is carried out on several levels <strong>of</strong> pharmacology, from<br />
molecular and cellular to clinical, covering both pharmacodynamics and pharmacokinetics.<br />
This gives depth to <strong>the</strong> teaching, is a source <strong>of</strong> motivation to <strong>the</strong><br />
teachers, and also <strong>of</strong>fers <strong>the</strong> students a broad range <strong>of</strong> projects to choose for<br />
<strong>the</strong>ir advanced studies.<br />
The senior teaching staff has been involved in <strong>the</strong> preparation <strong>of</strong> new Estonian<br />
language textbooks and teaching aids <strong>of</strong> pharmacology, which has forced<br />
<strong>the</strong> teachers to brush up <strong>the</strong>ir knowledge <strong>of</strong> pharmacology also in areas not<br />
central to <strong>the</strong>ir own research interests and to formulate a systematic view <strong>of</strong><br />
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SECTION I: SELF-EVALUATION<br />
44<br />
<strong>the</strong> aims and content <strong>of</strong> a modern curriculum <strong>of</strong> pharmacology for medical students.<br />
The textbooks are currently in use in <strong>the</strong> department, and are <strong>the</strong> following:<br />
• L. Allikmets, L. Nurmand. Pharmacology, Tartu, 1996, 670 pp,<br />
• L. Allikmets, L. Nurmand. Compendium Pharmacologicum. Tartu, 2000, 145<br />
pp,<br />
• M.-H. Otter, L. Nurmand. P. Pokk. Basics <strong>of</strong> Drug Prescription. Tartu, 2000,<br />
103 pp, and o<strong>the</strong>rs.<br />
During past few years we started <strong>the</strong> process <strong>of</strong> transition toward use <strong>of</strong><br />
electronic multimedia in a teaching process. Currently <strong>the</strong>re are available <strong>the</strong><br />
following courses (in Estonian) on-line:<br />
• Drug toxicology course (A.Zharkovsky, A. Kalda, A.Kaasik)<br />
• Pharmacology course for <strong>the</strong> students <strong>of</strong> dentistry (A. Zharkovsky, T. Zharkovsky,<br />
A. Kalda)<br />
• Electronic textbook in pharmacology "Ravim" (Drug) (A.Zharkovsky,<br />
P. Pokk, T. Kivastik, A. Lang).<br />
Weaknesses<br />
The weak point in our teaching process is our inability to provide all students<br />
with lab work, and via this methodology to demonstrate students how problems<br />
could solved scientifically.<br />
3. Describe <strong>the</strong> innovations in your teaching.<br />
The availability <strong>of</strong> modern textbooks <strong>of</strong> pharmacology (<strong>the</strong> latest previous edition<br />
was from 1982) has allowed a reduction in <strong>the</strong> number <strong>of</strong> lectures and a<br />
corresponding increase in <strong>the</strong> volume <strong>of</strong> problem-oriented seminars and discussions.<br />
The students taking <strong>the</strong> basic pharmacology course are about to<br />
finish <strong>the</strong>ir pre-clinical training, and are very eager to learn about diseases and<br />
<strong>the</strong>rapy. This high level <strong>of</strong> motivation is deliberately exploited in <strong>the</strong> teaching<br />
by presenting basic pharmacological principles in a clinically oriented, problem-based<br />
context.<br />
Critical evaluation <strong>of</strong> drug <strong>the</strong>rapies is being taught in a seminar or critical<br />
reading <strong>of</strong> published clinical study reports (compulsory) and on an elective<br />
course unit dealing specifically with <strong>the</strong> planning, conduct, interpretation and<br />
review <strong>of</strong> <strong>the</strong>rapeutic studies.<br />
A new integrated seminar in clinical <strong>the</strong>rapeutics is being <strong>of</strong>fered in <strong>the</strong> 1 th<br />
semester, organised jointly with <strong>the</strong> department <strong>of</strong> Internal Medicine. There<br />
are several electives, taught by <strong>Department</strong> members:<br />
• L. Allikmets: Pharmaco<strong>the</strong>rapy <strong>of</strong> infectious diseases<br />
• L. Allikmets, V. Matto: Pharmaco<strong>the</strong>rapy <strong>of</strong> Mental Disorders<br />
• T. Zharkovskaja: Antiinflammatory drugs<br />
• Zharkovsky, A. Kaasik A. Kalda: Introduction to Neurotoxicology (Theoretical<br />
course)
PHARMACOLOGY<br />
• Zharkovsky, A. Kaasik A. Kalda: Introduction to Neurotoxicology (Practical<br />
course)<br />
• Zharkovsky, A. Kaasik, A. Kalda: Methodology <strong>of</strong> preclinical research in<br />
pharmacology and Drug Toxcology (Practical course).<br />
• R. Pähkla, P. Pokk: Clinical Pharmacokinetics<br />
• R. Pähkla, A. Irs: Rational Drug Therapy<br />
• M. Otter: Use <strong>of</strong> Plants in Pharmaco<strong>the</strong>rapy<br />
• M. Otter: History <strong>of</strong> Pharmacology<br />
• M. Otter: Developmental Pharmacology<br />
• T. Kivastik, P.Pokk: Toxicology <strong>of</strong> Drug Dependence.<br />
4. <strong>Name</strong> <strong>the</strong> factors which most disturb your teaching (excluding financial resources).<br />
Over <strong>the</strong> past 10 years (1990-2000) <strong>the</strong> curriculum has changed twice, 1990<br />
and 1996. The first change was done because Estonia became independent<br />
and sum disciplines in medical curriculum had to be changed. The second<br />
change in curriculum was more detailed and devoted more to develop problem-based<br />
teaching and to give to <strong>the</strong> students to select additional elective<br />
courses.<br />
Until 1999 we worked in building constructed 200 years ago, and <strong>the</strong>re were<br />
several difficulties in organising both teaching and research. In August 1999<br />
we moved to brand new building were <strong>the</strong> lecture halls are equipped with all<br />
facilities for demonstrating materials on lectures and seminars.<br />
All three chairs in <strong>the</strong> department have educated personnel. During <strong>the</strong> past<br />
10 years 12 people have commenced doctoral degree. <strong>Department</strong> has 3<br />
pr<strong>of</strong>essors, three docents and 4 senior assistants.<br />
Computer-aided learning and teaching methods have so far been utilised<br />
only to a quite limited extent. This has been partly caused by <strong>the</strong> short-term<br />
nature <strong>of</strong> <strong>the</strong> teaching time, discouraging systematic curriculum development<br />
work. There are good teaching materials in electronic form in Estonian (pr<strong>of</strong>.<br />
Zharkovsky) but adoption <strong>of</strong> computer-aided methods would require a special<br />
room and considerable amount <strong>of</strong> preparatory work and self-produced written<br />
study compendia from <strong>the</strong> teachers. The teachers are able to prepare <strong>the</strong><br />
material.<br />
II EVALUATION OF THE TEACHING<br />
5. How is <strong>the</strong> quality <strong>of</strong> <strong>the</strong> teaching in your department evaluated?<br />
A systematic questionnaire-based student evaluation has been carried out at<br />
<strong>the</strong> end <strong>of</strong> <strong>the</strong> basic pharmacology course in <strong>the</strong> 5 th semester every o<strong>the</strong>r<br />
year. The questionnaire has encouraged <strong>the</strong> students to write additional comments<br />
on <strong>the</strong> teaching in a blank space reversed for non-structured answers.<br />
The results <strong>of</strong> this evaluation have been discussed in a staff meeting.<br />
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46<br />
The feedback-communication mechanism in drug toxicology and course <strong>of</strong><br />
pharmacology for dentistry has been established via network. The teachers<br />
are always informed about <strong>the</strong> students’ opinion on <strong>the</strong> ongoing courses. It is<br />
very valuable and efficient method <strong>of</strong> evaluation <strong>of</strong> <strong>the</strong> quality <strong>of</strong> <strong>the</strong> course. At<br />
<strong>the</strong> end <strong>of</strong> each year <strong>the</strong> scores obtained during examinations are evaluated<br />
statistically and analysed in <strong>the</strong> department meetings.<br />
The course <strong>of</strong> pharmaco<strong>the</strong>rapy, clinical pharmacology (8 th and 12 th semester)<br />
and toxicology (5 th semester) have been evaluated in an integrated<br />
student evaluation covering <strong>the</strong> entire semester.<br />
6. How are <strong>the</strong> content and <strong>the</strong> modes <strong>of</strong> teaching changed on <strong>the</strong> basis <strong>of</strong> this<br />
evaluation?<br />
The student evaluation <strong>of</strong> <strong>the</strong> teaching given by <strong>the</strong> department has been<br />
mostly favourable. Critical comments and suggestions have been discussed in<br />
staff meetings and improvements considered. The structure and proportion <strong>of</strong><br />
seminars and group works has been increased, and experiments have been<br />
reduced and made elective.<br />
7. Do you evaluate how <strong>the</strong> students use <strong>the</strong> textbooks recommended or o<strong>the</strong>r<br />
teaching material produced by <strong>the</strong> department?<br />
Examinations contain questions evaluating <strong>the</strong> use <strong>of</strong> recommended textbooks<br />
and o<strong>the</strong>r teaching material. Seminars are conducted in an interactive way<br />
with active student participation; reading <strong>of</strong> course materials is controlled in<br />
<strong>the</strong>se discussions.<br />
The available on-line teaching material and its use is evaluated in easy and<br />
efficient way. Each domain contains a counter enabling to count <strong>the</strong> number <strong>of</strong><br />
entries per week, month and year. For example, according to our estimation<br />
<strong>the</strong> number <strong>of</strong> entries into electronic textbook "Ravim" averages 25-30 entries<br />
per day.<br />
III PEDAGOGIC TRAINING OF STAFF<br />
8. How many <strong>of</strong> your teachers have received pedagogic training? List <strong>the</strong><br />
quality and quantity <strong>of</strong> this training?<br />
The teachers have had formal and some pedagogic training inside university.<br />
Most <strong>of</strong> pr<strong>of</strong>essors and docents have been participating also in international<br />
congress where <strong>the</strong> teaching methods and developments have been discussed.<br />
9. Is <strong>the</strong>re a need for fur<strong>the</strong>r pedagogic training <strong>of</strong> <strong>the</strong> teachers in your department?<br />
Always needed.
IV. COORDINATION OF TEACHING BETWEEN DEPARTMENTS<br />
PHARMACOLOGY<br />
10. How is <strong>the</strong> teaching co-ordinated with o<strong>the</strong>r departments? Indicate <strong>the</strong> departments<br />
that are closest to your department.<br />
Not much done, exept co-ordination between pharmacology, psychiatry, pulmonology<br />
and internal medicine, especially in teaching clinical pharmacology<br />
and elective courses.<br />
V. FUTURE PLANS AND CONCIUSIONS<br />
11. Future plans to improve <strong>the</strong> teaching given by <strong>the</strong> department.<br />
All future plans are based on <strong>the</strong> 5 year (1999-2004) plan <strong>of</strong> innovation and<br />
good practise in teaching pharmacology and toxicology at <strong>the</strong> department <strong>of</strong><br />
pharmacology.<br />
The major objective <strong>of</strong> this plan is to fur<strong>the</strong>r develop working knowledge and<br />
enable <strong>the</strong> medical graduate to review critically his or her own <strong>the</strong>rapeutic decision<br />
in patient management.<br />
Future plans to improve <strong>the</strong> teaching given by <strong>the</strong> department include <strong>the</strong><br />
following.<br />
• Fur<strong>the</strong>r develop computer-aided learning and teaching methods will be developed<br />
and introduced. This requires a considerable amount <strong>of</strong> preparatory<br />
work and more self-produced written study compendia from <strong>the</strong> teachers<br />
to enable <strong>the</strong> efficient use <strong>of</strong> English-language materials. Good programs<br />
are already available and in limited use in <strong>the</strong> department.<br />
• A new clinical pharmacological seminar on <strong>the</strong> use <strong>of</strong> problem-oriented<br />
drug information services is under development.<br />
• Participation <strong>of</strong> a clinical pharmacologist will be <strong>of</strong>fered to all clinical departments<br />
planning to give <strong>the</strong>rapeutically oriented elective courses.<br />
• New integrated elective courses will be planned and <strong>of</strong>fered in <strong>the</strong> following<br />
topics: “Pharmacology and antimicrobial agents”, “Methods <strong>of</strong> clinical trials”<br />
(focusing on drugs used in general practice and on addiction and drug dependence)<br />
(toge<strong>the</strong>r with Psychiatry and General Practice); “Pharmacological<br />
treatment <strong>of</strong> metabolic diseases” (toge<strong>the</strong>r with Internal Medicine)<br />
• In years 2002-2004 we intend to establish teleconferencing technology<br />
between pre- and clinical departments and start do develop <strong>the</strong> working<br />
links between clinical and preclinical departments - to fur<strong>the</strong>r implement <strong>the</strong><br />
problem -solving methodology in pharmacolgy teaching. curriculum.<br />
VI. CONCLUSIONS<br />
Pharmacology, toxicology and clinical pharmacology will continue to be central<br />
parts <strong>of</strong> <strong>the</strong> medical curriculum. Education in basic pharmacology will focus on<br />
molecular and cellular mechanism <strong>of</strong> drug action. Education in clinical phar-<br />
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macology will be problem-based and integrated with <strong>the</strong> clinical specialities.<br />
Modern textbooks and o<strong>the</strong>r teaching aids allow a fur<strong>the</strong>r reduction in <strong>the</strong><br />
number <strong>of</strong> lectures, and <strong>the</strong> quality <strong>of</strong> teaching can be fur<strong>the</strong>r improved by increasing<br />
<strong>the</strong> volume <strong>of</strong> clinically oriented problem-based seminars and group<br />
sessions. Modern teaching aids (computer programs and multimedia) will find<br />
an important place in <strong>the</strong> curriculum.
PHARMACOLOGY<br />
Pharmacology: resource evaluation<br />
1. Study materials<br />
- How many study books are published in your institution during last five years? 12<br />
- Do you have separate room as library in your place? Yes No<br />
- Could students borrow study books from your institution? Yes No<br />
- Do you have on-line published study materials for students? Yes No<br />
- WWW address: http://orpheus.med.ut.ee/ravim/<br />
- Does University library has enough modern books in your speciality?<br />
Completely enough Enough Scarcely Absolutely scarcely No<br />
2. Amount and size <strong>of</strong> study rooms<br />
- Rooms used by Your institution only: 1 rooms with area <strong>of</strong> 30 m 2<br />
- Rooms shared with ano<strong>the</strong>r institution: 1 rooms with area <strong>of</strong> 30 m 2<br />
- Do You have enough space for study process by Your opinion?<br />
Completely enough Enough Scarce Absolutely scarcely<br />
- How <strong>the</strong> scarce <strong>of</strong> space should be handled or changed?<br />
New building Change to smaller student groups Better logistics<br />
O<strong>the</strong>r way (describe shortly) Additional block with auditorium and teaching rooms to <strong>the</strong><br />
<strong>Biomeedikum</strong> (ca 1500 m2)<br />
3. Current situation <strong>of</strong> study rooms<br />
- There has been repairments in last years (except Biomedicum)<br />
- How are <strong>the</strong> study rooms lightened?<br />
Very good Good Some darkness Absolutely dark for study<br />
- Evaluation <strong>of</strong> general conditions: Very good Good Satisfactory Bad<br />
4. Your institution has<br />
a) 1 (how many?) auditorium(s) for workshops/seminars with 170 places, equipped with<br />
Blackboard<br />
White board & markers<br />
Screen<br />
Overhead projector<br />
Data projector<br />
Slide projector<br />
TV/Video projection set<br />
Computer<br />
Internet connection<br />
b) 1 (how many?) laboratories for practicals with places, equipped with<br />
Blackboard<br />
White board and markers<br />
Screen<br />
Overhead projector<br />
Data projector<br />
Slide projection kit<br />
TV/Video projection kit<br />
Computer<br />
Internet connection<br />
5. Working rooms for teaching staff and postgraduate students:<br />
- Number <strong>of</strong> teaching staff 14<br />
- Number <strong>of</strong> rooms for staff 6<br />
- Number <strong>of</strong> individual working places 14, among <strong>the</strong>m with computers 11<br />
- Number <strong>of</strong> postgraduate students is 7<br />
- How many individual working places <strong>the</strong>y have? 7<br />
- How many computers <strong>the</strong>y have? 6<br />
6. O<strong>the</strong>r comments on resource topic (max 250 letters): There is lack <strong>of</strong> teaching space<br />
in <strong>Biomeedikum</strong> and <strong>the</strong> shortage is increasing because <strong>the</strong> number <strong>of</strong> students<br />
increases<br />
49
SECTION I: APPENDIXES<br />
APPENDIX I-I<br />
Visits <strong>of</strong> <strong>the</strong> <strong>Department</strong> members to o<strong>the</strong>r institutions abroad during 1996-2000<br />
Year Researcher/Lectures Institution Country Purpose Duration<br />
1996 Aleksander Zarkovski Karolinska Institute Sweden Research 2 weeks<br />
1996 Anti Kalda University <strong>of</strong> Kuopio Finland Research 10 days<br />
1996 Jaanus Harro Uppsala BMC Sweden Research 2 weeks<br />
1996 Lembit Allikmets European Research Commision Belgium Research 9 days<br />
1996 Lembit Allikmets TU Dresden Germany Conference 10 days<br />
1996 Margareete Otter FELASA Switzeland Conference 6 days<br />
1996 Paavo Pokk The XXIV Nordic Meeting on Biological<br />
Research<br />
50<br />
Finland Conference 6 days<br />
1996 Toomas Marandi Karolinska Institute Sweden Research 3 weeks<br />
1996 Toomas Marandi Karolinska Institute Sweden Research 8 days<br />
1996 Vallo Matto TU Dresden Germany Conference 7 days<br />
1996 Vallo Matto University <strong>of</strong> Uppsala Sweden Research 3 months<br />
1997 Ants Kask Hammersmith Hospital, Wolfson<br />
Conference Centre<br />
England Research,<br />
conference<br />
5 days<br />
1997 Vallo Matto Karolinska Institute Sweden Research 24 months<br />
1998 Alar Irs Institute <strong>of</strong> organic syn<strong>the</strong>sis Latvia Research 12 days<br />
1998 Alar Irs University <strong>of</strong> Gröningen Holland Training 11 days<br />
1998 Alar Irs Center <strong>of</strong> Clinical Pharmacology<br />
Odense<br />
Danemark Training 2 months<br />
1998 Aleksander Zarkovski University <strong>of</strong> Helsinki Finland Research 7 days<br />
1998 Ants Kask University <strong>of</strong> Modena Italy Research,<br />
conference<br />
9 days<br />
1998 Ants Kask Los Angeles Convention Center USA Conference 10 days<br />
1998 Vallo Matto Medical University <strong>of</strong> Katowice Poland Conference 7 days<br />
1999 Aleksander Zarkovski ESBRA'99 Congress Spain Conference 6 days<br />
1999 Ants Kask Institute <strong>of</strong> Experimental Medicine Ungari Conference 10 days<br />
1999 Lembit Allikmets Congress <strong>of</strong> European Society <strong>of</strong><br />
Biological Psychiatry<br />
Italy Conference 7 days<br />
1999 Paavo Pokk ECNP Congress England Conference 6 days<br />
1999 Tatjana Skrebuhhova Latvian Academy <strong>of</strong> Sciences Latvia Training 13 days<br />
1999 Vallo Matto Latvian Academy <strong>of</strong> Sciences Latvia Training 13 days<br />
1999 Vallo Matto University <strong>of</strong> Helsinki Finland Research 12 months<br />
2000 Allen Kaasik Universite de Paris Sud France Research 1 month<br />
2000 Ants Kask Medical Institute <strong>of</strong> Hannover Germany Research 1 month<br />
2000 Kersti Oselin World Conference on Clinical Pharmacology<br />
Italy Conference 7 days<br />
2000 Maie Toomsalu International Workcentre Sonnenberg Germany Training 14 days<br />
2000 Vallo Matto ECNP Germany Conference 6 days
APPENDIX I-II<br />
PHARMACOLOGY<br />
Postgraduate students at <strong>the</strong> <strong>Department</strong> having studied abroad during 1996-2000<br />
Year <strong>Name</strong> Institution Contry Duration<br />
1996 Ants Kask University <strong>of</strong> Latvia Latvia 7 days<br />
1996 Toomas Marandi Karolinska Institute Sweden 5 days<br />
1996 Anti Kalda University <strong>of</strong> Kuopio Finland 7 days<br />
1996 Vallo Matto University <strong>of</strong> Uppsala Sweden 4 months<br />
1998 Alar Irs University <strong>of</strong> Odense Denmark 2 months<br />
2000 Kersti Oselin Humboldt-University Berlin Germany 8 months<br />
2000 Külli Jaako University <strong>of</strong> Kuopio Finland 1month<br />
2001 Kersti Oselin Humboldt-University Berlin Germany 5 months<br />
APPENDIX I-III<br />
Co-operation with institutions from o<strong>the</strong>r countries and participation in international<br />
research projects during 1996-2000<br />
Contact person Institution Country Aim<br />
Sen res. Anti Kalda University <strong>of</strong> Helsinki, Haartman Institute, Dep. Of<br />
Medical Genetics<br />
Finland Research<br />
Pr<strong>of</strong>. Aleksander Zarkovski University <strong>of</strong> Helsinki, Haartman Institute, Dep. Of<br />
Medical Genetics<br />
Finland Research<br />
Sen. ass. Vallo Matto University <strong>of</strong> Helsinki, Institute <strong>of</strong> Pharmacy Finland Research<br />
Pr<strong>of</strong>. Aleksander Zarkovski University <strong>of</strong> Kuopio, Dep. <strong>of</strong> Neuroscience and Neurology<br />
Finland Research<br />
Docent Margareete Otter University <strong>of</strong> Kuopio Finland Research<br />
Sen. ass. Toomas Kivastik Karolinska Institute, Dep. <strong>of</strong> Clinical Neuroscience Sweden Research<br />
Pr<strong>of</strong>. Aleksander Zarkovski Karolinska Institute, Dep. <strong>of</strong> Clinical Neuroscience Sweden Research<br />
Pr<strong>of</strong>. Lembit Allikmets University <strong>of</strong> Göttingen Germany Cooperation<br />
Sen.ass. Ants Kask University <strong>of</strong> Uppsala Sweden Research<br />
Sen.res. Allen Kaasik University Paris-Sud France Research<br />
Res. Alar Irs University <strong>of</strong> Odense Denmark Research<br />
Doctorant Kersti Oselin Humboldt-University Berlin, Institute <strong>of</strong> Clinical Pharmacology<br />
Germany Research<br />
Sen. ass Ants Kask Medical University <strong>of</strong> Hannover Germany Research<br />
Sen. Ass. Ants Kask University <strong>of</strong> McGill Canada Research<br />
Pr<strong>of</strong>. Aleksander Zarkovski University <strong>of</strong> Lund, Wallenberg Neuroscience Center Sweden Research<br />
Pr<strong>of</strong>. Aleksander Zarkovski University <strong>of</strong> Uppsala, Biomedical Centre Sweden Research<br />
Pr<strong>of</strong>. Aleksander Zarkovski Instituto Nazionale Neurologico "C.Besta" Italy Research<br />
Pr<strong>of</strong>. Aleksander Zarkovski Martin Lu<strong>the</strong>r University Halle-Wittenberg Germany Research<br />
51
SECTION I: APPENDIXES<br />
APPENDIX I-IV<br />
Visiting lecturers at <strong>the</strong> <strong>Department</strong> during 1996-2000<br />
Visitor Institution Country Purpose <strong>of</strong> <strong>the</strong> Visit<br />
Arnold Hasselblatt University <strong>of</strong> Göttingen Germany Research,promotion, lectures,cooperation,<br />
several times<br />
Izjaslav Lapin Becterev Psychoneurological Institute<br />
Russia Lectures, opponent, several times<br />
Liisa Ahtee University <strong>of</strong> Helsinki Finland Opponent<br />
Matti Paasonen University <strong>of</strong> Helsinki Finland Research<br />
Edward Walaszek University <strong>of</strong> Kansas USA Research<br />
Mauno Airaksinen University <strong>of</strong> Kuopio Finland Research<br />
Vija Klusa University <strong>of</strong> Latvia Latvia Lectures, opponent<br />
Heiko Iven University <strong>of</strong> Lübeck Germany Research<br />
Karl-Friedrich Sewing Hannover Medical University Germany Lectures<br />
APPENDIX I-V<br />
Scientific journals available at <strong>the</strong> <strong>Department</strong><br />
No <strong>Name</strong> <strong>of</strong> Journal Version<br />
1. Aggressive Behavior paper<br />
2. Arzneimittel-Forschung. Drug Research paper<br />
3. Baltic Journal <strong>of</strong> Laboratory Animal Science paper<br />
4. Behavioral Brain Research online<br />
5. Biological Psychiatry.A Journal <strong>of</strong> Psychiatric Neuroscience paper<br />
6. Brain Research online<br />
7. Deutsches Ärzteblatt paper<br />
8. European Neuropsychopharmacology paper<br />
9. Journal <strong>of</strong> Neuroscience online<br />
10. Journal <strong>of</strong> Pharmacology and Experimental Therapeutics online<br />
11. Journal <strong>of</strong> Psychopharmacology paper<br />
12. Nature online<br />
13. Nature Neuroscience online<br />
14. Naunyn-Schmiedeberg's Archives <strong>of</strong> Pharmacology paper<br />
15. Neuroscience online<br />
16. Neuroscience Letters online<br />
17. Neuroscience Research online<br />
18. Pharmacology&Toxicology paper<br />
19. Pharmacology, Biochemistry and Behavior paper<br />
20. Progress in Neurobiology online<br />
21. The International Journal <strong>of</strong> Neuropsychopharmacology paper<br />
22. The Sciences paper<br />
23. The World Journal <strong>of</strong> Biological Psychiatry paper<br />
24. Trends in Neurosciences online<br />
25. Trends in Pharmacological Siences paper, online<br />
52
APPENDIX I-VI<br />
Publications <strong>of</strong> <strong>the</strong> <strong>Department</strong> members during 1996-2000<br />
MONOGRAPHS<br />
PHARMACOLOGY<br />
1. Rägo L. Regulation and location <strong>of</strong> peripheral benzodiazepine binding sites. Kuopio, 1991, 156 lk.<br />
50. Harro J. Studies on <strong>the</strong> brain cholecystokinin receptors and behaviour. Uppsala, 1993, 115 lk.<br />
51. Kivastik T. Mechanisms <strong>of</strong> drug addiction: focus on positive reinforcing properties <strong>of</strong> morphine. TÜ<br />
Kirjastus, Tartu, 1996, 108 lk.<br />
52. Pokk P. Stress due to sleep deprivation: focus on GABAA receptor-chloride ionophore complex. TÜ<br />
Kirjastus, Tartu, 1996, 106 lk.<br />
53. Pähkla R. Studies in pinoline pharmacology. TÜ Kirjastus, Tartu, 1997, 112 lk.<br />
54. Kaasik A. Thyroid hormone control over β-adrenergic signalling system in rat atria. TÜ Kirjastus,<br />
Tartu, 1998, 75 lk.<br />
55. Matto V. Pharmacological studies on anxiogenic and antiaggressive properties <strong>of</strong> antidepressants.<br />
TÜ Kirjastus, Tartu, 1998, 142 lk.<br />
56. A.Kalda. Oxygen-glucose deprivation-induced neuronal death and its pharmacological prevention<br />
in cerebellar granule cells. Tartu, 1999,119 lk.<br />
57. A.Kask. Behavioural studies on neuropeptide Y. Tartu, 1999, 135 lk.<br />
58. T.Marandi. Drug treatment <strong>of</strong> depression in Estonia. Tartu, 1999, 127 lk.<br />
59. Skrebuhhova-Malmros T. Serotonin receptors in <strong>the</strong> action <strong>of</strong> antidepressants. Master Thesis,<br />
Tartu, 2000, 60 lk.<br />
60. L.Allikmets, L.Nurmand. Farmakoloogia. (õpik üliõpilastele ja käsiraamat arstidele ning proviisoritele),<br />
TÜ Kirjastus, Tartu, 1996,<br />
61. M.Otter. Farmakokineetika ja seda mõjustavad tegurid. Ilmub 2001.a. (käsikiri on valmis)<br />
PAPERS IN INTERNATIONAL JOURNALS<br />
1. Gvido Cebers, Aleta Cebere, Aleksander Zharkovsky. Glycine does not reverse <strong>the</strong> inhibitory actions<br />
<strong>of</strong> ethanol on NMDA receptor functions in cerebellar granule cells. Naunyn-Schmiedeberg's<br />
Arch. Pharmacology, 1996, vol. 354, pp. 1-10.<br />
2. Gvido Cebers, Yan-Ning Hou, Aleta Cebers, Lars Terenius, Sture Liljequist. Chronic ethanol enhances<br />
NMDA-induced AP-1 activity in cultured rat cerebellar granule cells. NeuroReport, 1996,<br />
vol. 7, pp. 000-007.<br />
3. Yan-Ning Hou, Gvido Cebers, Aleta Cebere, Lars Terenius, Sture Liljequist. N-methyl-D-aspartateinduced<br />
enhancement <strong>of</strong> activator protein-1 DNA binding activity is blocked by ethanol in cerebellar<br />
granule cells. European Journal <strong>of</strong> Pharmacology, 1996, vol. 309, pp. 307-310.<br />
4. Yan-Ning Hou, Mila Vlaskovska, Gvido Cebers, Lubomir Kasakov, StureLiljequist, Lars Terenius. A<br />
μ-receptor opioid agonist induces AP-1 and NF-κB transcription factor activity in primary cultures <strong>of</strong><br />
rat cortical neurons. Neuroscience Letters, 1996, vol. 212, pp. 159-162.<br />
5. Jaanus Harro. The 1st regional meeting <strong>of</strong> European College <strong>of</strong> Neuropsychopharmacology<br />
(ECNP): current aspects in <strong>the</strong> psychopharmacology <strong>of</strong> mood disorders. Meeting Reports. CNS,<br />
vol. 5, No 3, Fall, 1996 pp. 4-12.<br />
6. Jaanus Harro, Lars Oreland. Depression as a spreading neuronal adjustment disorder. European<br />
Neuropsychopharmacology, 1996, v. 6, pp. 207-223.<br />
7. Jaanus Harro, Charlotta Löfberg, Rein Pähkla, Vallo Matto, Lembit Rägo, Lars Oreland, Lembit Allikmets.<br />
Different molecular forms <strong>of</strong> cholecystokinin and CCKB receptor binding in <strong>the</strong> rat brain<br />
after chronic antidepressant treatment. Naunyn-Schmiedeberg's Arch. Pharmacol., 1996, v. 354,<br />
pp. 1-7.<br />
8. Jaanus Harro, Charlotta Löfberg, Jens Rehfeld, Lars Oreland. Cholecystokinin peptides and receptors<br />
in <strong>the</strong> rat brain during stress. Naunyn-Schmiedeberg's Arch. Pharmacol., 1996, v. 354, pp.<br />
59-66.<br />
9. Ants Kask, Lembit Rägo, Jaanus Harro. Anxiogenic-like effect<strong>of</strong> <strong>the</strong> neuropeptide Y Y1 receptor<br />
antagonist BIBP3226: antagonism with diazepam. European Journal <strong>of</strong> Pharmacology, 1996, pp.<br />
10. T.Kivastik, J.Rutkauskaite, A.Zharkovsky. Nitric oxide syn<strong>the</strong>sis inhibition attenuates morphineinduced<br />
place preference. Pharmacology, Biochemistry & Behaviour, 1996, vol. 53, No 4, pp. 1013-<br />
1015.<br />
11. Toomas Kivastik, Kati Vuorikallas, T. Petteri Piepponen, Alexander Zharkovsky and Liisa Ahtee.<br />
Morphine- and cocaine-induced conditioned place preference: effects <strong>of</strong> quinpirole and preclamol.<br />
Pharmacology, Biochemistry & Behaviour, 1996, vol. 54, No 2, pp. 371-375.<br />
53
SECTION I: APPENDIXES<br />
12. C.Löfberg, J.Harro, C.-G.Gottfries, L.Oreland. Cholecystokinin peptides and receptor binding in<br />
Alzheimer's disease. J. Neural. Transm., 1996, v. 103, pp. 851-860.<br />
13. T.Marandi, M.L.Dahl, R.A.Kiivet, L.Rägo, F.Sjöqvist. Debrisoquin and S-mephenytoin hydroxylation<br />
phenotypes and CYP2D6 genotypes in an Estonian population. Pharmacology & Toxicology, 1996,<br />
vol. 78, pp. 303-307.<br />
14. V.Matto, J.Harro, L.Allikmets. The effects <strong>of</strong> cholecystokinin A and B receptors antagonists,<br />
devazepide and L 365260, on citalopram-induced decrease <strong>of</strong> exploratory behaviour in rats. Journal<br />
<strong>of</strong> Physiology and Pharmacology, 1996, vol. 47, No 4, pp. 661-669.<br />
15. L.Nurmand. Zur Geschiehte der Pharmakologie an der Universität zu Tartu (Dorpat). Mitteilungen,<br />
1996, No 19, 58-63.<br />
16. T. Petteri Piepponen, Jaana Katajamäki, Toomas Kivastik, Alexander Zharkovsky, Liisa Ahtee. Behavioural<br />
and neurochemical sensitization <strong>of</strong> morphine-withdrawn rats to quinpirole. Pharmacology,<br />
Biochemistry & Behaviour, 1996, vol. 54, No 4, pp. 787-792.<br />
17. Paavo Pokk, Toomas Kivastik, Diana Sobol, Sture Liljequist, Alexander Zharkovsky. Is upregulation<br />
<strong>of</strong> benzodiazepine receptors a compensatory reaction to reduced GABAergic tone in <strong>the</strong> brain <strong>of</strong><br />
stressed mine? Naunyn-Schmiedeberg's Arch. Pharmacol., 1996, vol. 354, pp. 1-7.<br />
18. Paavo Pokk, Sture Liljequist, Alexander Zharkovsky. Ro 15-4513 potentiates, instead <strong>of</strong> antagonizes,<br />
ethanol-induced sleep in mice exposed to small platform stress. European Journal <strong>of</strong> Pharmacology,<br />
1996, pp.<br />
19. Rein Pähkla, Jaanus Harro and Lembit Rägo. Behavioural effects <strong>of</strong> pinoline in <strong>the</strong> rat forced<br />
swimming, open field and elevated plus-maze tests. Pharmacological Research, 1996, vol. 33, No<br />
2, pp. 1-6.<br />
20. Rein Pähkla, Raivo Masso, Mihkel Zilmer, Lembit Rägo and Mauno M.Airaksinen. Autoradiographic<br />
localization <strong>of</strong> [ 3H]-pinoline binding sites in mouse tissues. Meth. Find. Exp. Clin. Pharmacol.,<br />
1996, vol. 18, No 6, pp. 359-366.<br />
21. L.Rägo. Estonian Regulatory Affairs. The Regulatory Affairs Journal, 1996, vol. 7, No 7, pp. 567-<br />
573.<br />
22. Lembit Rägo. Multisource (generic) pharmaceutical products: guidelines on registration requirements<br />
to establish interchangeability. 34. Report. WHO Technical Report Series, No 863, 1996, pp.<br />
115-154.<br />
23. J.M.Aiache, A.Andayaningsih, N.Aoyagi, E.Beyssac, D.Blois, H.Blume, A.Bondani, M.Cone,<br />
M.N.Dauramanzi, T.Fushimi, U.Gundert-Remy, C.G. Guyer, F.D.Juma, G.Kreutz, L.Lacy,<br />
I.J.McGilveray, O.Morin, R.Nedich, R.Nijkerk, H.P.Osterwald, T.L.Paal, R.N.Patnaik, J.M.Peon,<br />
M.C.Pikaert, L.Rägo, B.Rosenkranz, H.Scheinin, N.Uemura, R.L.Williams. Multisource (generic)<br />
pharmaceutical products: quidelines on registration requirements to establisch interchangeability.<br />
In <strong>the</strong> book: Quality Assurance <strong>of</strong> Pharmaceuticals. A compendium <strong>of</strong> quidelines and related materials,<br />
1997, vol.1, World Health Organization, Geneva, pp. 62-104.<br />
24. J.Harro, C.Löfberg, R.Pähkla, V.Matto, L.Rägo, L.Oreland, L.Allikmets. Different molecular forms<br />
<strong>of</strong> cholecystokinin and CCKb receptor binding in <strong>the</strong> rat brain after chronic antidepressant treatment.<br />
Naunyn-Schmiedeberg’s Arch. Pharmacol., 1997, vol355, pp. 57-63.<br />
25. A.Kalda, E.Eriste, V.Vassiljev,A.Zharkovsky. Medium transitory oxygen-glucose deprivation induced<br />
both apoptosis and necrosis in cerebella granule cells. Neuroscience Letters, 1997, vol.239,<br />
pp. 1-4.<br />
26. A.Kask, J. Harro, P.Tuomainen, L.Rägo, P.Männisto. Overflow <strong>of</strong> noradrenalive and dopamine in<br />
frontal cortex after [N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine] (DSP-4) treatment: in vivo microdialysis<br />
study in anaes<strong>the</strong>tized rats. Naun-Schmiedeberg’s Arch. Of Pharmacology, 1997, vol.<br />
355, No 2, p.267-272.<br />
27. A.Kask, L.Rägo,J.Harro. α-Helical CRF9-41 prevents anxioogenic-like effect <strong>of</strong> NPY Y1 receptor<br />
antagonist BIBP3226 in rats. NeuroReport, 1997, vol. 8, No 16, p. 3645-3647.<br />
28. T.Marandi,M.-L.Dahl, L.Rägo, R.Kiivet, F.SjöQvist. Debrioquine and S-mephenytoin hydroxylation<br />
polymorphisms in Russian population living in Estonia. Eur. J. <strong>of</strong> Clin. Pharmacol., 1997, vol. 53,<br />
Issue ¾, pp.257-260.<br />
29. V.Matto, L.Allikmets, T.Skrebuhhova. Apomorphine-induced aggressiveness and [3H]citalopram<br />
binding after antidepressant treatment in rats. Pharmacol. Biochem. Behav., 1997, vol. 59, No 2,<br />
pp.1-6.<br />
30. V. Matto,J.Harro, L.Allikmets. The effect <strong>of</strong> drugs acting on CCK receptors and rat free expioration<br />
in <strong>the</strong> exploration box. J. <strong>of</strong> Physiol. Pharmacol., 1997, vol. 48, No 2, pp. 239-251.<br />
31. V.Matto, J.Harro, L.Allikmets. The effect <strong>of</strong> cholecystokinin A and B receptor antagonists on exploratory<br />
behaviour in <strong>the</strong> elevated zero-maze in rat. Neuropharmacology, 1007, vol.36, No 3,<br />
pp.389-396.<br />
54
PHARMACOLOGY<br />
32. M.Otter, K.Otter. Qutstanding representative <strong>of</strong> Estonian experimental pharmacology: Georg Kingisepp.<br />
Acta Medico-Historica Rigensia, 1997, vol. III(XXII), p. 217-221.<br />
33. M.Otter, T.Skrebuhhova, V.Matto, J.Harro. Measurement <strong>of</strong> exploratory behaviour in rat. Proaeding<br />
<strong>of</strong> <strong>the</strong> Sixt FELASA Symposium, 19-21 June 1997, Basel Swtzerland.In: Harmonization <strong>of</strong> Laboratory<br />
Animal Husbandry, 1997, pp. 21-23.<br />
34. M.-H.Otter, V.Matto, R.Sôukand, T.Skrebuhhova, L.Allikmets, J.Harro. Characterization <strong>of</strong> rat exploratory<br />
behaviour using <strong>the</strong> exploratory box test. Meth. Find. Clin. Pharmacol., 1997, vol. 19, No<br />
10, pp. 683-691.<br />
35. T.P.Piepponen, T.Kivastik, J.Kivastik, J.Katajamäki, A.Zharkovsky. L.Ahtee. Involvement <strong>of</strong> opioid<br />
μ1 receptors in morphine-induced conditioned place preference in rats. Pharmacol. Biochem. Behav.,<br />
1997, vol. 58, No 1, pp. 275-279.<br />
36. P.Pokk, A.Zharkovsky. The effect <strong>of</strong> flumazenil, Ro 15-4513 and β-CCM on <strong>the</strong> behaviour <strong>of</strong> control<br />
and stressed mice in <strong>the</strong> plus-maze test. J. <strong>of</strong> Physiol. Pharmacol., 1997, vol. 48, No 2, pp.<br />
253-261.<br />
37. R.Pähkla, R.Masso, L.Rägo, M.M.Airaksinen. [3H]pinoline binding sites: autoradiographic visualization<br />
and characterization. Acta Medica Baltica, 1996, vol. 3, No 3, pp. 218-226.<br />
38. R.Pähkla, L.Rägo. High affinity binding <strong>of</strong> [3H]citalopram in rat adrenals. Pharm. Pharmacol. Lett.,<br />
1997, vol. 7, No 1, pp. 13-16.<br />
39. R.Pähkla, L.Rägo, J.Callaway, M.M.Airaksinen. Binding <strong>of</strong> pinoline on <strong>the</strong> 5-hydroxytryptamine<br />
transporter: competitive interaction with [3H]citalopram. Pharmacol. Toxicol., 1997, vol. 80, pp.<br />
122-126.<br />
40. L.Rägo. Pharmaceutical inspection in Estonia. The Regulatory Affairs Journal, 1997, vol. 8, No 4,<br />
pp. 248-251.<br />
41. J.Shlik, V.Vasar, A.Aluoja, P.H.Kingisepp, K.Jagomägi, V.Vasar, L.Rägo, J.Bradwejn. The effect <strong>of</strong><br />
cholecystokinin tetrapeptide on respiratory resistance in healthy volunteers. Biology Psychiatry,<br />
1997, vol. 42, No 3, pp. 206-212.<br />
42. L.H.Allikmets, L.G.Polevoi, A.M.Zharkovsky, V.I.Gunar, V.M.Kopelevitsh, L.N.Bulanova, M.J.Otter.<br />
Neurobutaal (kaltsiumoksübutüraat) - uus nootroopne preparaat. I. Farmakoloogiline skriining ja<br />
biokeemilised uuringud. Nootroopsed preparaadid. Moskva, 1998, lk. 138-148 (vene keeles).<br />
43. A.Kalda, E.Eriste, V.Vassiljev, A.Zharkovsky. Medium transitory oxygen- glucose deprivation induced<br />
both apoptosis and necrosis in cerebellar granule cells. Neuroscience Letters, 1998, vol.<br />
240, pp. 21-24.<br />
44. A.Kask, J.Harro, L.Rägo. Opposite effects <strong>of</strong> [Leu 13 , Pro 34 ]NPY and NPY13-36 on hypnotic response<br />
to α2-adrenoceptor agonist dexmedetomidine microinjected into rat locus coeruleus. Neuroscience<br />
Research Communications, 1998, vol. 23, No 1, pp. 41-43.<br />
45. A.Kask, F.Mutulis, R.Muceniece, R.Pähkla, I.Mutule, J.E.S.Wikberg, L.Rägo, H.B.Schiöth. Discovery<br />
<strong>of</strong> a novel superpotent and selective melanocortin-4 receptor antagonist (HS024): evaluation in<br />
vitro and in vivo. Endocrinology, 1998, vol. 139, No 12, pp. 5006-5014.<br />
46. A.Kask, L.Rägo, J.Harro. Anxiolytic-like effect <strong>of</strong> neuropeptide Y (NPY) and NPY13-36 microinjected<br />
into vicinity <strong>of</strong> locus coeruleus. Brain Research, 1998, vol. 788, pp. 345-348.<br />
47. A.Kask, L.Rägo, J.Harro. NPY Y1 receptors in <strong>the</strong> dorsal periaqueductal gray matter regulate anxiety<br />
in <strong>the</strong> social interaction test. NeuroReport, 1998, vol. 9, pp. 2713-2716.<br />
48. A.Kask, L.Rägo, J.Harro. Anxiolytic-like effect <strong>of</strong> neuropeptide NPY Y1 receptor antagonist<br />
BIB3226 administered into <strong>the</strong> dorsal periaqueductal gray matter in rats. Regulatory Peptides,<br />
1998, vol. 75-76, pp. 255-262.<br />
49. A.Kask, L.Rägo, J.Harro. Evidence for involvement <strong>of</strong> neuropeptide Y receptors in <strong>the</strong> regulation <strong>of</strong><br />
food intake: studies with Y1-selective antagonist BIBP3226. British Journal <strong>of</strong> Pharmacology, 1998,<br />
vol. 124, pp. 1507-1515.<br />
50. A.Kask, L.Rägo, F.Mutulis, R.Pähkla. Selective antagonist for <strong>the</strong> melanocortin 4 receptor (HS014)<br />
increases food intake in free-feeding rats. Biochemical and biophysical Research Communications,<br />
1998, vol. 245, pp. 90-93.<br />
51. A.Kask, L.Rägo, P.Korrovits, J.E.S.Wikberg, H.B.Schiöth. Evidence that orexigenic effects <strong>of</strong> melanocortin<br />
4 receptor antagonist HS014 are mediated by neuropeptide Y. Biochemical and Biophysical<br />
Research communications, 1998, vol. 248, pp. 245-249.<br />
52. A.Kask, L.Rägo, J.E.S.Wikberg, H.B.Schiöth. Evidence for involvement <strong>of</strong> <strong>the</strong> melanocortin MC4<br />
receptor in <strong>the</strong> effect <strong>of</strong> leptin on food intake and body weight. European J. Pharmacology, 1998,<br />
vol. 360, pp. 15-19.<br />
53. J.Katajamäki, A.Honkanen, T.P.Piepponen, I.-B.Linden, A.Zharkovsky, L.Ahtee. Conditioned<br />
placepreference induced by a combination <strong>of</strong> L-Dopa and a COMT inhibitor, entacapone, in rats.<br />
Pharmacol. Biochem. Behav., 1998, vol. 60, No 1, pp. 23-26.<br />
55
SECTION I: APPENDIXES<br />
54. C.Löfberg, J.Harro, V.Matto, L.Oreland. Cholecystokinin peptides and receptor binding in rat brain<br />
after DSP-4 treatment. Neuropeptides, 1998, vol. 32, No 2, pp. 103-108.<br />
55. T.Marandi, V.Vasar, L.Rägo. The pattern <strong>of</strong> use <strong>of</strong> antidepressants in Estonia in 1996. Nord Psykiatr<br />
Tidsskr, 1998, vol. 52, No 6, pp. 465-473.<br />
56. V.Matto, L.Allikmets. Rat exploratory behaviour after acute or repeated antidepressant treatment in<br />
open-field and exploration-box tests. Baltic J. Lab. Anim. Sci., 1998, vol. 8, pp. 145-157.<br />
57. V.Matto, L.Allikmets. Rapid changes in <strong>the</strong> affinity <strong>of</strong> <strong>the</strong> 5-hydroxytryptamine transporter binding<br />
sites in rat frontal cortex after single citalopram injection. Pharmaceutical and Pharmacological<br />
Letters, 1998, vol. 8, No 4, pp. 90-92.<br />
58. V.Matto, L.Allikmets. Comparison <strong>of</strong> rat exploratory behaviour after noradrenergic denervation in<br />
elevated zero-maze and open tests. Baltic J. Lab. Anim. Sci., 1998, vol. 8, pp. 16-19.<br />
59. V.Matto, L.Allikmets. Apomorphine-induced aggressive and nonaggressive rats differ in<br />
[ 3 H]raclopride-sensitive D2 receptor binding characteristics. Medical Science Research, 1998, vol.<br />
26, pp. 499-501.<br />
60. V.Matto, L.Allikmets, T.Skrebuhhova. Apomorphine-induced aggressiveness and [ 3 H]citalopram<br />
binding after antidepressant treatment in rats. Pharmacol. Biochem. Behav., 1998, vol. 59, No 3,<br />
pp. 747-752.<br />
61. V.Matto, T.Skrebuhhova, L.Allikmets. The effect <strong>of</strong> antidepressants on rat aggressive behavior in<br />
<strong>the</strong> electric footshock and apomorphine-induced aggressiveness paradigms. Meth. Find. Exp. Clin.<br />
Pharmacol., 1998, vol. 20, No 4, pp. 329-337.<br />
62. M.J.Otter, L.H.Alllikmets, A.M.Zharkovsky, L.G.Polevoi. Neurobutaal (kaltsiumoksübutüraat) - uus<br />
nootroopne preparaat. II. Biosaadavus ja toimed kestval manustamisel. Nootroopsed preparaadid.<br />
Moskva, 1998, lk. 149-158 (vene keeles).<br />
63. P.Pokk, A.Zharkovsky. The effect <strong>of</strong> buspirone on <strong>the</strong> behaviour <strong>of</strong> control and stressed mice. J. <strong>of</strong><br />
Physiol. Pharmacol., 1998, vol. 49, No 1, pp. 175-186.<br />
64. P.Pokk, A.Zharkovsky. Small platform stress attenuates <strong>the</strong> anxiogenic effect <strong>of</strong> diazepam withdrawal<br />
in <strong>the</strong> plus-maze test. Behavioural Brain Rssearch, 1998, vol. 98, pp. 153-157.<br />
65. R.Pähkla, M.Zilmer, T.Kullisaar, L.Rägo. Comparison <strong>of</strong> <strong>the</strong> antioxidant activity <strong>of</strong> melatonin and<br />
pinoline in vitro. J. Pineal Res., 1998, vol. 24, pp. 96-101.<br />
66. L.Rägo. An update <strong>of</strong> regulatory affairs in Estonia. NLN Baltic Conference 1998. Clinical Trials <strong>of</strong><br />
Medicines - Opportunities and Challenges in <strong>the</strong> Baltic Region. June 15-16, 1998, Vilnius Lithuania.<br />
NLN Publication No 49. Nordic Council on Medicines, Uppsala, 1998, pp. 19-24.<br />
67. V.Vassiljev, A.Kalda, P.Pokk, M.Väli, A.Zharkovsky. Modified method for <strong>the</strong> induction <strong>of</strong> ethanol<br />
dependence in mice. Baltic J. Lab. Anim. Sci., 1998, vol. 8, pp. 89-92.<br />
68. V.Vassiljev, A.Kalda, P.Pokk, M.Väli, A.Zharkovsky. Nitric oxide synthase inhibitor 7-nitroindazole<br />
attenuates <strong>the</strong> behavioural signs <strong>of</strong> ethanol withdrawal due to pharmacokinetic interaction. Med.<br />
Sci. Res., 1998, vol. 26, pp. 821-822.<br />
69. V.Vassiljev, A.Kalda, P.Pokk, M.Väli, A.Zharkovsky. The effect <strong>of</strong> <strong>the</strong> nitric oxide synthase inhibitor<br />
7-nitroindazole on ethanol pharmacokinetics in rats after acute and chronic ethanol administration.<br />
Alcohol & Alcoholism, 1998, vol. 33, No 6, pp. 609-615.<br />
70. E.De Sousa, V.Veksler, A.Minajeva, A.Kaasik, P.Mateo, E.Mayoux, J.Hoerter, X.Bigard,<br />
B.Serrurier, R.Ventura-Clapier. Subcellular creatine kinase alterations implications in heart failure.<br />
Circulation Research, 1999, vol. 85, pp. 68-76.<br />
71. J.Harro, R.Häidkind, M.Harro, A.-R.Modiri, P.-G.Gillberg, R.Pähkla, V.Matto, L.Oreland. Chronic<br />
mild unpredictable stress after noradrenergic denervation: attenuation <strong>of</strong> behavioural and biochemical<br />
effects <strong>of</strong> DSP-4 treatment. Eur. Neuropsychopharm., 1999, vol. 10, pp. 5-16.<br />
72. J.Harro, R.Pähkla, A.-R.Modiri, M.Harro, A.Kask, L.Oreland. Dose-dependent effects <strong>of</strong><br />
noradrenergic denervation by DSP-4 treatment on forced swimming and β-adrenoceptor binding in<br />
<strong>the</strong> rat. J. Neural. Transm., 1999, vol. 106, pp. 619-629.<br />
73. A.Kaasik, A.Minajeva, E.De Sousa, R. Ventura-Clapier, V.Veksler. Nitric oxide inhibits cardiac energy<br />
production via inhibition <strong>of</strong> mitochondrial creatine kinase. FEBS Letters, 1999, vol. 444, pp.<br />
75-77.<br />
74. A.Kaasik, V.Vassiljev, E.Põldoja, A.Kalda, A.Zharkovsky. Do nuclear condensation or fragmentation<br />
and DNA fragmentation reflect <strong>the</strong> mode <strong>of</strong> neuronal death?. NeuroReport, 1999, vol. 10, No 9,<br />
pp. 1937-1942.<br />
75. A.Kalda, A.Kaasik, V.Vassiljev, P.Pokk, A.Zharkovsky. Neuroprotective action <strong>of</strong> group I metabotropic<br />
glutamate receptor agonists against oxygen-glucose deprivation-induced neuronal death.<br />
Brain Research, 1999, 28246, pp. 1-3.<br />
76. A.Kalda, A.Zharkovsky. Metabotropic glutamate receptor agonists protect from oxygen-glucose<br />
deprivation- and colchicines-induced apoptosis in primary cultures <strong>of</strong> cerebellar granule cells. Neuroscience,<br />
1999, vol. 92, No 1, pp. 7-14.<br />
56
PHARMACOLOGY<br />
77. A.Kask, J.Harro. Inhibition <strong>of</strong> amphetamine- and apomorphine-induced behavioural effects by neuropeptide<br />
Y Y1 receptor antagonist BIBO 3304. Neuropharmacology, 1999, vol. 39, pp. 1-11.<br />
78. A.Kask, T.Kivastik, L.Rägo, J.Harro. Neuropeptide Y Y1 receptor antagonist BIBP3226 produces<br />
conditioned place aversion in rats. Prog. Neuro-Psychopharmacol. & Biol. Psychiat., 1999, vol. 23,<br />
pp. 705-711.<br />
79. A.Kask, R.Pähkla, A.Irs, L.Rägo, J.E. Wikberg, H.B.Schiöth. Long-term administration <strong>of</strong> MC4 receptor<br />
antagonist HS014 causes hyperphagia and obesity in rats. NeuroReport, 1999, vol. 10, pp.<br />
707-711.<br />
80. V.Matto, T.Skrebuhhova, L.Allikmets. Apomorphine-induced upregulation <strong>of</strong> serotonin 5-HT2A receptors<br />
in male rats is independent from development <strong>of</strong> aggressive behaviour. J. Physiol. Pharmacol.,<br />
1999, vol. 50, No 2, pp. 335-345.<br />
81. V.Matto, L.Allikmets. Rat exploratory behaviour after acute or repeated antidepressant treatment in<br />
open-field and exploration-box tests. Baltic J. Lab. Anim. Sci., 1999, vol. 8, pp. 145-147.<br />
82. V.Matto, L.Allikmets. Acute and chronic citalopram treatment differently modulates rat exploratory<br />
behaviour in <strong>the</strong> exploration box test: no evidence for increased anxiety or changes in <strong>the</strong><br />
[ 3 H]raclopride binding. Pharmacology, 1999, vol. 58, pp. 59-69.<br />
83. V.Matto, L.Allikmets. Apomorphine-induced aggressive and nonaggressive rats differ in<br />
[ 3 H]raclopride-sensitive D2 receptor binding characteristics. Medical Science Research, 1999, vol.<br />
26, pp. 499-501.<br />
84. M.Otter. Kuusikymmentä vuotta ensimmäisen Viron farmakopean voimaantulosta. Hippokrates.<br />
Suomen Lääketieteen Historian Seuran vuosikirja, 1999, lk. 163-167.<br />
85. M.Otter Sata vuotta huomattavan virolaisen kokullisen farmakologian edustajan Georg Kingiseppin<br />
syntymästä. Hippokrates. Suomen Lääketieteen Historian Seuran vuosikirja, 1999, 16 vuosikerta,<br />
lk 157-161.<br />
86. T.P.Piepponen, A.Honkanen, T.Kivastik, A.Zharkovsky, A.Turtia, J.A.V.Mikkola, L.Ahtee. Involvement<br />
<strong>of</strong> opioid μ1-receptors in opioid-induced acceleration <strong>of</strong> striatal and limbic dopaminergic<br />
transmission. Pharmacol. Biochem. Behav., 1999, vol. 63, No 2, pp. 245-252.<br />
87. T.P.Piepponen, A.Zharkovsky, T.Kivastik, L.Ahtee. Effects <strong>of</strong> morphine in rats withdrawn from repeated<br />
nifedipine administration. Eur. J. Pharmacol., 1999, vol. 365, pp. 159-164.<br />
88. P.Pokk. The effect <strong>of</strong> piracetam after repeated elevated plus-maze exposure in rats. Baltic J. Lab.<br />
Anim. Sci., 1999, vol. 9, pp. 142-148.<br />
89. R.Pähkla, A.Irs, K.Oselin, L.Rootslane. Digoxin: use pattern in Estonia and bioavailability <strong>of</strong> <strong>the</strong> local<br />
market leader. J. Clinical Pharm Therap., 1999, vol. 24, pp. 375-380.<br />
90. R.Pähkla, J.Lambert, P.Ansko, P.Winstanley, P.D.O.Davies, R.-A.Kiivet. Comparative bioavailability<br />
<strong>of</strong> three different preparations <strong>of</strong> rifampicin. J. Clinical Pharm Therap., 1999, vol. 24, pp. 219-<br />
225.<br />
91. R.Rudissaar, K.Pruus, T.Skrebuhhova, L.Allikmets, V.Matto. Modulatory role <strong>of</strong> 5-HT3 receptors in<br />
mediation <strong>of</strong> apomorphine-induced aggressive behaviour in male rats. Behav. Brain Res., 1999,<br />
vol. 106, pp. 91-96.<br />
92. T.Skrebuhhova, L.Allikmets, V.Matto. 5-HT2A receptors in rat brain after acute monoamine depletion.<br />
Pharm. Pharmacol. Lett., 1999, vol. 27, pp. 277-280.<br />
93. T.Skrebuhhova, L.Allikmets, V.Matto. Effects <strong>of</strong> anxiogenic drugs in rat forced swimming test.<br />
Methods Findx. Exp. Clin. Pharmacol., 1999, vol. 21, No 3, pp. 173-178.<br />
94. T.Skrebuhhova, L.Allikmets, V.Matto. [ 3 H]ketanseriin binding and elevated plus-maze behaviour<br />
after chronic antidepressant treatment in DSP-4 and p-CPA pretreated rats: evidence for partial involvement<br />
<strong>of</strong> 5-HT2A receptors. Methods Findx. Exp. Clin. Pharmacol., 1999, vol. 21, No 7, pp. 483-<br />
490.<br />
95. T.Skrebuhhova-Malmros, L.Allikmets, R.Rudissaar, K.Pruus, V.Matto. Ondansetron fails to reverse<br />
antidepressant-elicited antiexploratory effects in <strong>the</strong> elevated plus-maze anf open field tests. ;edical<br />
Science Research, 1999, vol. 27, pp. 835-837.<br />
96. V.Vassiljev, M.Väli, P.Pokk. Effect <strong>of</strong> nitric oxide synthase inhibitors L-NAME and L-NOARG on<br />
behavioural signs <strong>of</strong> ethanol withdrawal. Med. Sci. Res., 1999, vol 27, pp. 409-410.<br />
97. T.Skrebuhhova-Malmros, K.Pruus, R.Rudissaar, L.Allikmets, V.Matto. Modulation <strong>of</strong> forced swimming,<br />
open field and apomorphine-induced aggressive behaviour by 5-HT2A and 5-HT3 receptor<br />
ligands in male Wistar rats. Pharmaceutical and Pharmacological Letters, 1999, vol. 9, No 2, pp.<br />
70-73.<br />
98. M.Väli, V.Vassiljev, I.Drikkit, D.Lepik, A.Kalda, P.Pokk, A.Zharkovsky. Programmed cell death as<br />
phenomena in <strong>the</strong> CNS during ethanol withdrawal. Proceedings <strong>of</strong> <strong>the</strong> 3rd Congress <strong>of</strong> BMLA, Riga<br />
(Jurmala), August 19-21, 1998. Medicina Legalis Baltica, 1999, vol. 10, pp. 133-138.<br />
99. A.Zharkovsky, J.Katajamäki, T.Seppälä, L.Ahtee. Morphine-induced analgesia in rats wirhdrawn<br />
from concurrent nimodipine and morphine treatment. Pain, 1999, vol. 79, pp. 217-222.<br />
57
SECTION I: APPENDIXES<br />
100. Kalda A., Kaasik A., Vassiljev V., Pokk P., Zharkovsky A. Neuroprotective action <strong>of</strong> group I metabotropic<br />
glutamate receptor agonists against oxygen-glucose deprivation-induced neuronal<br />
death. Brain Research, 2000, vol. 853, No. 2, p. 370-373.<br />
101. Kask A., Eller M., Oreland L., Harro J. Neuropeptide Y attenuates <strong>the</strong> effect <strong>of</strong> locus coeruleus denervation<br />
by DSP-4 treatment on social behaviour in <strong>the</strong> rat. Neuropeptides, 2000, vol. 34, pp. 58-<br />
61.<br />
102. Kask A., Harro J. Inhibition <strong>of</strong> amphetamine and apomorphine-induced behavioural effects by<br />
neuropeptide Y Y1 receptor antagonist BIBO 3304. Neuropharmacology, 2000, vol. 39, pp. 1292-<br />
1302.<br />
103. Kask A., Rägo L., Wikberg J.E.S., Schiöth, H.B. Differential effects <strong>of</strong> melanocortin peptides on<br />
feeding in rats: Evidence against <strong>the</strong> involvement <strong>of</strong> MC3 receptor in <strong>the</strong> regulation <strong>of</strong> food intake.<br />
Neuroscience Letters, 2000, vol. 283, pp. 1-4.<br />
104. Kask A., Schiöth, H.B., Harro J., Wikberg J.E.S., Rägo L. Orexigenic effect <strong>of</strong> <strong>the</strong> melanocortin 4<br />
receptor antagonist HS014 is inhibited only partially by neuropeptide Y Y1 receptor selective antagonists.<br />
Canadian Journal <strong>of</strong> Physiology and Pharmacology, 2000, vol. 78, pp. 143-149.<br />
105. Kask A., Schiöth H.B., Mutulis F., Wikberg J.E.S., Rägo L. Anorexigenic cocaine- and amphetamine-regulated<br />
transcript (CART) peptide intensifies fear reactions in rats. Brain Research, 2000,<br />
vol. 857, pp. 283-285.<br />
106. Kask A., Schiöth H.B. Tonic inhibition <strong>of</strong> food intake during inactive phase is reversed by <strong>the</strong> injection<br />
<strong>of</strong> <strong>the</strong> melanocortin MC4 receptor antagonist into <strong>the</strong> paraventricular nucleus <strong>of</strong> <strong>the</strong> hypothalamus<br />
and central amygdala <strong>of</strong> <strong>the</strong> rat. Brain Research, 2000, vol. 887, pp. 462-466.<br />
107. Matto V., Vaarmann A., Rudissaar R., Pruus K., Skrebuhhova-Malmros T., Allikmets L. Apomorphine-induced<br />
aggressive behaviour and post-mortem monoamine content in male Wistar rats.<br />
Neuroscience Letters, 2000, 289:131-134.<br />
108. Otter M. Georg Dragendorff (1836-1898). Maineikas farmasian, farmakognosian ja oikeuskemian<br />
kehittäja. Hippokrates, 2000, pp. 141-155.<br />
109. Otter M. The first <strong>of</strong>ficial Estonian Pharmacopoeia. Acta Medico-Historica Rigensia. Pauli<br />
Stradine Museum Historiae Medicinal, Riga, 2000, vol. V (XXIV), pp. 247-250.<br />
110. Otter M. The founder <strong>of</strong> chronobiology – Nikolai Pärna. Acta Medico-Historica Rigensia. Pauli<br />
Stradine Museum Historiae Medicinal, Riga, 2000, vol. V (XXIV), pp. 163-167.<br />
111. Pokk P., Vassiljev V., Väli M. The influence <strong>of</strong> <strong>the</strong> nitric oxide synthase inhibitor L-NAME on <strong>the</strong><br />
effects <strong>of</strong> ethanol in rats after acute ethanol administration. Medical Science Research 2000, vol.<br />
28, p.7-8.<br />
112. Pokk P., Vassiljev V., Väli M. The effect <strong>of</strong> bacl<strong>of</strong>en on <strong>the</strong> locomotor activity <strong>of</strong> control and smallplatform-stressed<br />
mice. Pharmacological Research, 2000, vol. 42, No 3, p. 235-237.<br />
113. Pokk P., Vassiljev V., Väli M. Small platform stress increases [ 3 H] Ro 15-4513 binding in <strong>the</strong><br />
cerebellum <strong>of</strong> mice. Fundamental & Clinical Pharmacology, 2000, vol. 14, p. 487-491.<br />
114. Pruus K., Rudissaar R., Skrebuhhova-Malmros T., Allikmets L., Matto V. Development <strong>of</strong> apomorphine-induced<br />
aggressive behavior: Comparison <strong>of</strong> adult male and female Wistar rats. Methods<br />
and Findings in Experimental and Clinical Pharmacology. 2000, vol. 22, No 1, pp. 47-50.<br />
115. Pruus K., Rudissaar R., Skrebuhhova-Malmros T., Allikmets L., Matto V. [3H]citalopram binding in<br />
cerebral cortex after antidepressant treatment in monoamine-impaired rats. Bolletino Chimico Farmaceutico,<br />
2000, vol. 139, No 1, pp. 41-45<br />
116. Pruus K, Skrebuhhova-Malmros T, Rudissaar R, Matto V, Allikmets L. 5-HT1A receptor agonists<br />
buspirone and gepirone attenuate apomorphine-induced aggressive behaviour in adult male Wistar<br />
rats. Journal <strong>of</strong> Physiology and Pharmacology, 2000, vol. 51, No 4, pp. 833-846.<br />
117. Pähkla R., Kask A., Rägo L. Differential effects <strong>of</strong> beta-carbolines and antidepressants in elevated<br />
zero maze test in rats. Pharmacology, Biochemistry and Behavior, 2000, vol. 65, No 4, pp.<br />
737-742.<br />
118. Rudissaar R., Pruus K., Skrebuhhova-Malmros T., Allikmets L., Matto V. Involvement <strong>of</strong> GABAergic<br />
neurotransmission in <strong>the</strong> neurobiology <strong>of</strong> <strong>the</strong> apomorphine-induced aggressive behavior paradigm,<br />
a model <strong>of</strong> psychotic behavior in rats. Methods Find. Exp. Clin. Pharmacol., 2000, vol. 22, No<br />
9, pp. 1-4<br />
119. Rägo L. The benefits and risks <strong>of</strong> self-medication. WHO Drug Information, 2000, vol. 14, No 1,<br />
pp. 1-2.<br />
120. Skrebuhhova-Malmros T., Pruus K., Rudissaar R., Allikmets L., Matto V. The serotonin 5-HT2A<br />
receptor subtype does not mediate apomorphine-induced aggressive behaviour in male Wistar<br />
rats. Pharmacology, Biochemistry and Behavior, 2000, vol. 67, pp. 339-343.<br />
121. Vassiljev V., Mesila I., Väli M., Pokk P. The influence <strong>of</strong> <strong>the</strong> nitric oxide synthase inhibitor L-<br />
NOARG on <strong>the</strong> effects <strong>of</strong> ethanol in rats after acute ethanol administration. Pharmacology & Toxicology,<br />
2000, vol. 86, p. 63-67.<br />
58
PHARMACOLOGY<br />
122. Lembit Allikmets and Vallo Matto. Changes in brain monoaminergic systems in apomorphinesensitized<br />
aggressive male Wistar rats. In: Prevention and control <strong>of</strong> aggression and <strong>the</strong> impact on<br />
victims (ed.: M. Martinez), Kluver Academic/Plenum Publishers, N.Y., 2001 in press.<br />
123. A.Kaasik, A.Kalda, K.Jaako, A.Zharkovsky. Dehydroepiandrosterone sulphate prevents oxygenglucose<br />
deprivation-induced injury in cerebellar granule cell culture. Neuroscience 2000 (in press)<br />
124. A.Kalda. Aju isheemilise kahjustuse molekulaarsed mehhanismid. Eesti Arst (vastu võetud publitseerimiseks)<br />
125. T.Kivastik, S.Liljequist Prolonged treatment with non-competitive NMDA receptor antagonist dizocilpine<br />
reduce voluntary ethanol intake in Wistar ratsSubmitted to European Journal <strong>of</strong> Pharmacology<br />
126. T.Kivastik, S.Liljequist The Nmda/Glycine Site Antagonist, L-701,324, Does Not Antagonize Cocaine-Stimulated<br />
Dopamine Release In The Nucleus Accumbens – A Microdialysis Study Submitted<br />
to Journal <strong>of</strong> Pharmacology and Experimental Therapeutics<br />
127. V. Matto, A. Vaarmann, L. Allikmets. Apomorphine-induced aggressive behaviour in parachlorophenylalanine-treated<br />
male rats: implications to brain [3H]ketanserin binding and monoamine<br />
content. Pharmacology and Toxicology, 2001, in press<br />
128. V. Matto, A. Vaarmann, K. Pruus, R. Rudissaar, T. Skrebuhhova-Malmros, L. Allikmets. Moderately<br />
increased dopamine metabolism in apomorphine-aggressive adult male Wistar rats post<br />
mortem. Pharmaceutical and Pharmacological Letters, 2000–2001, in press<br />
129. Vallo Matto, Lembit Allikmets. Apomorphine-induced aggressive behaviour in adult male Wistar<br />
rats: a reliable model <strong>of</strong> psuchotic behaviour. Submitted to Baltic Journal <strong>of</strong> Laboratory Animal Science<br />
130. P.Pokk, E.Sepp, V.Vassiljev, M.Väli. The effects <strong>of</strong> <strong>the</strong> nitric oxide synthase inhibitor 7nitroindazole<br />
on <strong>the</strong> behaviour <strong>of</strong> mice after chronic ethanol administration. Alcohol & Alcoholism<br />
(accepted 20.12.2000)<br />
131. P.Pokk, M.Väli. Small platform stress increases exploratory activity <strong>of</strong> mice in staircase test. Progress<br />
in Nreuro-Psychopharmacology & Biological Psychiatry (accepted 15.09.2000).<br />
132. R. Rudissaar, K. Pruus, A. Vaarmann, P. Pannel, T. Skrebuhhova-Malmros, L. Allikmets, V.<br />
Matto. Acute trazodone and quipazine treatment attenuates apomorphine-induced aggressive behaviour<br />
in male rats without major impact on emotional behaviour or post mortem monoamine<br />
content. Pharmacological Research, 2001, in press.<br />
133. K. Pruus, A. Vaarmann, L. Allikmets, V. Matto. Five- minutes forced swimming decreases noradrenaline<br />
content in rat frontal cortex. Submitted to Baltic Journal <strong>of</strong> Laboratory Animal Science.<br />
134. T. Skrebuhhova, L. Allikmets, V. Matto Additive effect <strong>of</strong> clonidine and fluoxetine on apomorphine-induced<br />
aggressive behaviour in adult male Wistar rats, Resubmitted to Archives <strong>of</strong> Medical<br />
Research<br />
PAPERS IN ESTONIAN JOURNALS<br />
1. L.Allikmets. Rudolf Buchheim (1820-1879). Raamatus: Eestia arstiteaduse ajaloost. Koostanud<br />
Viktor Kalnin. Tartu Ülikooli Kirjastus, 1996, lk. 75-80.<br />
2. L.Allikmets. Agressiivse käitumise farmakoloogia ja farmakoteraapia. Eesti Arst, 1996, No 1, lk. 49-<br />
54.<br />
3. V.Kalnin, M.Otter. Georg Dragendorff (1836-1898). Raamatus: Eesti arstiteaduse ajaloost. Koostanud<br />
Viktor Kalnin. TÜ Kirjastus, Tartu, 1996, lk. 99-108.<br />
4. Vallo Matto, Lembit Allikmets. Koletsüstokiniin kesknärvisüsteemis. Eesti Arst, 1996, No 5, lk. 426-<br />
432.<br />
5. L.Nurmand. Oswald Schmiedeberg (1838-1921). Raamatus: Eesti arstiteaduse ajaloost. Koostanud<br />
Viktor Kalnin. Tartu Ülikooli Kirjastus, 1996, lk. 115-118.<br />
6. M.Otter. Ravimite kasutamisest raseduse ajal. Eesti Rohuteadlane, 1996, No 1, lk. 17-24.<br />
7. Lembit Rägo. Pricing principles and price levels in Estonia. NLN Publication No 2, Nordiska Läkemedelsnämnden,<br />
Nordic Council on Medicines, Uppsala 1996. NLN Baltic Conference 1996, 17-18<br />
June 1996, Tallinn, pp. 91-93.<br />
8. A.Lamp, M.Otter, A.Raal. Ankeetküsitlus sôltumusainete kasutamise kohta Tartu üliôpilaste hulgas<br />
1997.a. Eesti Rohuteadlane, 1997, Nr. 3, lk. 5-6<br />
9. T.Marandi, J.Ruut, L.Rägo, R.A.Kiivet, F.Sjöqvist. Debrisoguiini ja S-mefenütoiini hüdroksüülimise<br />
polümorfism Eestis elaval vene elanikkonnal. Eesti Arst, 1997, Nr. 12, lk.<br />
10. T.Marandi,J.Ruut, L.Rägo, T. Agan, L.Aru, E.Ester, A.Järv, J.Müürsepp, T.Pärlin, S.Vääri, H.Vasar,<br />
M.Saarma, V.Vasar. Amitriptülliini ja imipramiini plasmakontsentratsioonide seos nende erinevate<br />
manustamisviiside ja ravi efektiivsusega depressioonihaigetel. Eesti Arst, 1997, Nr.4, lk. 316-324.<br />
11. M.Otter.Alkohol pôhjustab biorütmide desünkroosi. Eesti Rohuteadlane, 1997, Nr. 1, lk. 16-17.<br />
59
SECTION I: APPENDIXES<br />
12. M. Otter. 160 aastat Tartu suurima rohuteadlase J. Dragendorfi sunniest II. Eesti Rohuteadlane,<br />
1997, Nr.1, lk. 8-10.<br />
13. T.Marandi, L.Rägo, V.Vasar. Depressioonihaigete raviskeemide analüüs Tartu Ülikooli Kliinikumi<br />
Psühhiaatriahaiglas. Eesti Arst, 1998, nr. 1, lk. 24-31.<br />
14. M.Otter. Tänavused kolm suurt tähtpäeva farmakoloogias. Fr.R.Faehlmann - 200 aastat sünnist.<br />
Eksperimentaalfarmakoloogia - 150 aastat. G.Kingisepp - 100 aastat sünnist. Eesti Rohuteadlane,<br />
1998, nr. 1, lk. 27-30.<br />
15. M.Otter. Medical legislation <strong>of</strong> <strong>the</strong> Republic <strong>of</strong> Estonia in 1937. Annual Report 1997. Museum <strong>of</strong><br />
Tartu University History. Tartu, 1998, vol. 2<br />
16. M.Otter. 150th anniversary <strong>of</strong> experimental pharmacology in Tartu. Annual Report 1997. Museum<br />
<strong>of</strong> Tartu University History. Tartu, 1998, vol. 2<br />
17. M.Otter. 200 aastat eesti rahvusest arsti, materia medica õppejõu ja kirjamehe Fr.R.Faehlmanni<br />
sünnist. Eesti Arst, 1998, nr. 1, lk. 70-75.<br />
18. A.Lamp, M.Otter. Narkootikumide kasutamine Tartu üliõpilaste hulgas aastail 1997-1998. Eesti<br />
Arst, 1999, nr 6, lk 524-526.<br />
19. A.Lamp, M.Otter. Narkootikumide kasutamine Tartu üliõpilaste hulgas aastail 1997…1998 (I). Eesti<br />
Rohuteadlane, 1999, nr 1, lk 3-5.<br />
20. A.Lamp, M.Otter. Narkootikumide kasutamine Tartu üliõpilaste hulgas aastail 1997…1998 (II).<br />
Eesti Rohuteadlane, 1999, nr 2, lk 3-5.<br />
21. A.Lamp, M.Otter. Alkoholi kasutamine Tartu üliõpilaste hulgas 1998 aastal. Eesti Arst, 1999, nr 5,<br />
402-407.<br />
22. K.Oselin, A.Irs, L.Rägo. Tsütokroom P450 isoensüüm CP3A4 ja sellega seotud raviminteraktsioonid.<br />
Eesti Arst, 1999, nr 5, lk 450-455.<br />
23. M.Otter. Legaalsed ja illegaalsed narkootikumid. Eesti Rohuteadlane, 1999, nr 3, lk 5-8.<br />
24. M.Otter. 120 aastat Tartu Ülikooli Farmakoloogia Instituudi looja R.Buchheimi surmast. Eesti Rohuteadlane,<br />
1999, nr 2, 19-21.<br />
25. M.Otter. 200 aastat eesti rahvusest arsti, material medica õppejõu ja kirjamehe Fr. R.Faehlmanni<br />
sunniest. Eesti Arst, 1999, nr 1, lk 70-75.<br />
26. M.Otter. Georg Barkan – Tartu Ülikooli farmakoloogiapr<strong>of</strong>essor aastatel 1929-1938. Eesti Arst,<br />
1999, nr 4, lk 356-360.<br />
27. Otter M. Psühhostimuleeriva toimega sõltumusained. Eesti Rohuteadlane, 1999, nr 4, lk. 17-19.<br />
28. R.Rudissaar, K.Pruus, T.Skrebuhhova, L.Allikmets, V.Matto. [ 3 H]tsitalopraami sidumine roti ajukoores<br />
DSP-4 ja p-CPA manustamise järgselt. Eesti Rohuteadlane, 1999,. Nr 1, lk 9-11<br />
29. L.Rägo, K.Raudsepp. Praha: kaks konverentsi, üks eesmärk. Eesti Rohuteadlane, 1999, nr 1, lk<br />
28-30.<br />
30. Allikmets L. 25 aastat arstiteaduskonna aastapäeva järjekindlat tähistamist. Eesti Arst, 2000, nr 3,<br />
lk. 528-529.<br />
31. M.Otter. Tähtsamad vannideks kasutatavad ravimtaimed. Kodutohter, 1996, No 2, lk. 42.<br />
32. M.Otter. Kohvist. Kodutohter, 1996, No 1, lk. 60-62.<br />
33. M.Otter. Psühhostimulaatorid - amfetamiinid. Kodutohter, 1996, lk. 16-17.<br />
34. M.Otter. Kas tulivesi hukutab eestlased? Horisont, 1996, No 4, lk. 30-32.<br />
35. M.Otter. Üks probleemike ehitusbioloogi töömailt - kiirgussaaste. Ehitaja, 1996, N. 12.<br />
36. M.Otter. E.C.H.Schmidt ("Wasser-Schmidt"). Kalender "Olion", 1997, Tallinn, 1996, lk. 109-112.<br />
37. M.Otter. Vabatahtlik surmaotsus. Kodutohter, 1996, N. 5, lk. 8-10.<br />
38. M.Otter. Mônda kohvist ja k<strong>of</strong>eiinijookidest. Kalender "Olion" 1997, Tallinn, 1996, lk. 136-139.<br />
39. M.Otter. Jälgi ravimi säilitusaega. Kodutohter, 1996, No 6, lk. 21-22.<br />
40. M.Otter. Mida ma tean oma ravimist?. Kodutohter, 1996, N. 5, lk. 50.<br />
41. M.Otter. Maagilised seened. Kodutohter I, 1996, N. 6, lk. 14-15.<br />
42. M.Otter, V.Kalnin. 160 aastat Tartu suurima rohuteadlase Georg Dragendorffi sünnist I. Eesti Rohuteadlane,<br />
1996, N. 4, lk. 8-11.<br />
43. M.Otter. Kiirgussaastest. Kalender 1998, Kirjastus Olion, Tallinn, 1997, lk. 109-110.<br />
44. M.Otter. LSD lugu. Kalender 1998. Kirjastus Olion, Tallinn 1997.<br />
45. M.Otter. Mis on LSD? Horisont, 1997, nr 6, lk.22.<br />
46. M.Otter, E.Mere. Aspiriin – kas igaks elujuhtumiks? Pere ja kodu, 1997, nov., lk. 14.<br />
47. M.Otter. Oopium, heroin, hiina valge. Kodutohter, 1997, nr 4, lk. 12-13.<br />
48. M.Otter. Kokaiin. Kodutohter, 1997, nr. 3, lk. 6-7.<br />
49. M.Otter. Biorütmid pärast pidu. Terviseleht, 18. juuni 1997, nr. 25(197), lk. 10.<br />
50. M.Otter. Suveajast loobudes säästame tervist. Terviseleht, 19. marts, 1997, nr 12(184).<br />
51. M.Otter. Hašiš ja marihuana. Kodutohter, 1997, nr 2, lk. 8-9.<br />
52. M.Otter. Kui ohtlik on ecstasy? Kodutohter, 1997, nr 2, lk. 10-12.<br />
53. M.Otter. Eesti narkodiilerite vôrgus. Kodutohter, 1997, nr. 2, lk. 12-13.<br />
60
PHARMACOLOGY<br />
54. M.Otter. Elektromagnetilised vônked häirivad meie biorütme. Terviseleht, 23. aprill 1997, nr.<br />
17(189), lk. 4.<br />
55. M.Otter. Suveajas pole midagi head. Postimees Extra, laupäev 27. marts, 1997, nr. 14(209).<br />
56. M.Otter. Rinnapiim ja ravimid. Pere ja Kodu, 1997, marts 3, lk. 39.<br />
57. M.Otter. LSD môjul tekivad müstilised kogemused, ilmneb fantastiline maailm. Kodutohter, 1997,<br />
nr. 1, lk. 17-18.<br />
58. M.Otter. Tudeng ja narkootikumid. Kodutohter, 1997, nr. 5, lk. 22-23.<br />
59. M.Otter. Kes tôi kanepi Euroopasse? Mis on marihuana? Mis on hašiš? Horisont, 1997, nr. 7, lk.<br />
25.<br />
60. M.Otter. Inimese ööpäev vööndiaja järgi. Postimees Extra, laupäev, 27. märts 1997, nr. 14(209).<br />
61. M.Otter. Maitsetaimed. Terviseleht, 17. detsember 1997, lk. 5.<br />
62. M.Otter. Iidsed armujoogid. Kodutohter, 1998, nr. 1, lk. 44-46.<br />
63. M.Otter. Millal avastati amfetamiinid? Horisont, 1998, nr. 6 (september), lk. 12-13.<br />
64. M.Otter. Teie küsimustele vastab. Pere ja Kodu, 1998, september, lk. 47.<br />
65. M.Otter. Mis on ecstasy? Horisont, 1998, nr. 2, lk. 30-31.<br />
66. M.Otter. Armas apteek avita! Pere ja Kodu, 1998, nr. 2, lk. 12-13.<br />
67. M.Otter. Taimed appi. Pere ja Kodu, 1998, nr. 4, lk. 15.<br />
68. M.Otter. Maitsetaimed. Kodutohter, 1998, nr. 2, lk. 56-58.<br />
69. M.Otter. 150 aastat eksperimentaalfarmakoloogiat Tartus ja kogu maailmas. “Kalender 1999”, kirjastus<br />
“Olion”, 1998, lk. 75-77.<br />
70. M.Otter. Kanepist valmistatud sôltumusained. “Kalender 1999”, kirjastus “Olion”, 1998, lk. 87-91.<br />
71. M.Otter. Eelärkamisaja suurkuju - Friedrich Robert Faehlmann. Horisont, 1998, nr. 8, lk. 8-10.<br />
72. M.Otter. Suveajas pole midagi head. Tervis, marts 1999, lk 28-30.<br />
73. M.Otter. Narkoäri on käibelt maailmas kolmandal-neljandal kohal. Ärielu, juuli 1999, lk. 30-31.<br />
74. M.Otter. Lahustid kui inimese seisundit muutvad ühendid. Kirjastus “Olion”, 1999, Kalender 200, lk.<br />
146-182.<br />
75. M.Otter. Toidutaimede raviomadusi. Kirjastus “Olion”, 1999, Kalender 2000, lk 179-182<br />
76. M.Toomsalu. Kuidas sai Johann Wolfgang Goe<strong>the</strong>st meditsiinidoktor? Horisont, 1999, nr 1, lk 31.<br />
77. Ernits P., Kaasik A., Palli I., Reinap A., Piller M. Miks INFARKT armastab eestlasi?. Luup, 2000,<br />
20. marts, nr. 6, lk. 115.<br />
78. Kaasik A. Intervjuu Tartu Ülikooli farmakoloogiapr<strong>of</strong>essor Aleksander Zarkovskiga “Purjus hiired kiusavad<br />
nõrgemat”. Luup, 2000, 7. veebruar, nr. 3, lk. 112.<br />
79. Kaasik A. Pätiks sündinud?. Internetiväljaanne morning.ee, 10.10.2000<br />
80. Otter M., Otter K. Uute ravimite aprobatsioon. Horisont 2000, nr 3, lk. 36-37.<br />
81. Otter M. Ravimid ja unenäod. Stiil, jaanuar 2000, lk. 64.<br />
82. Otter M. Kas Eesti peaks suveajale üle minema? Luup, 2000, nr. 4 (113), 21. veebruar, lk. 19.<br />
83. Otter M. Põldosi osteoporoosi vastu. Kodutohter, 2000, nr. 9, lk. 51-52.<br />
84. Otter M. Osteoporoos. Minu Tervis, oktoober 2000.<br />
85. Otter M. Maitsetaimede ravitoimetest. Kirjastus “Olion”, Kalender 2001, Tallinn, 2000, lk. 143-144.<br />
86. Otter M. Maitsetaimed. Kirjastus “Olion”, Kalender 2001, Tallinn, 2000, lk. 139-143.<br />
TEXTBOOKS AND MANUALS<br />
1. L.Allikmets, L.Nurmand. Farmakoloogia ja toksikoloogia programm ning kordamisküsimused arstiteaduskonna<br />
üliôpilastele. Tartu Ülikooli Kirjastus, Tartu, 1996, 28 lk.<br />
2. L.Allikmets, L.Nurmand, M.Otter, A.Zarkovski. Raviainete klassifikatsioon. TÜ Kirjastus, Tartu,<br />
1996, 50 lk.<br />
3. Leo Nurmand, Margareete Otter, Tamara Zarkovskaja. Farmakoteraapia ülesandeid. Tartu Ülikooli<br />
Kirjastus, Tartu, 1996, 53 lk.<br />
4. L.Allikmets, L.Nurmand. Farmakoloogia ja toksikoloogia programm ning kordamisküsimused arstiteaduskonna<br />
üliôpilastele. Tartu, 1998, TÜ Kirjastus, 28 lk.<br />
5. L.Allikmets, L.Nurmand, M.Otter, A.Zarkovski. Raviainete klassifikatsioon. Tartu, 1998, TÜ Kirjastus,<br />
49 lk.<br />
6. L.Nurmand, M.Otter, T.Zarkovskaja. Farmakoteraapia ülesandeid. Tartu, 1998, TÜ Kirjastus,<br />
7. M.Otter, L.Nurmand, P.Pokk. Retseptuuri pôhijooni. Tartu, 1998, TÜ Kirjastus, 104 lk.<br />
8. M.Otter. Toidu- ja maitsetaimede raviomadusi. Tartu, 1998, 241 lk.<br />
61
APPENDIX I-VII<br />
Academic and administrative personnel: <strong>Department</strong> <strong>of</strong> Pharmacology<br />
PHARMACOLOGY<br />
<strong>Name</strong> Title Load Area Gender Birth year Scientific degree Year <strong>of</strong> commencement Labour time (y)<br />
1. Lembit Allikmets Pr<strong>of</strong>essor 1,00 Pharmacology Male 1936 Dr.Sci 1970 37<br />
2. Aleksander Zarkovski Pr<strong>of</strong>essor 1,00 Toxicology Male 1950 Dr.Sci 1987 26<br />
3. Lembit Rägo Pr<strong>of</strong>essor 1,00 Clinical Pharmacology Male 1955 Dr.Sci 1991 16<br />
4. Rein Pähkla Docent 1,00 Clinical Pharmacology Male 1966 Dr.Med 1997 9<br />
5. M.-H.Otter Docent 1,00 Pharmacology Female 1937 Ph.D 1968 25<br />
6. Tamara Zarkovskaja Docent 1,00 Pharmacology Female 1954 Ph.D 1982 20<br />
7. Vallo Matto Lecturer 1,00 Pharmacology Male 1969 Dr.Med 1998 5<br />
8. Toomas Kivastik Lecturer 1,00 Pharmacology Male 1970 Dr.Med 1996 10<br />
9. Paavo Pokk Lecturer 1,00 Toxicology Male 1966 Dr.Med 1996 10<br />
10. Ants Kask Lecturer 1,00 Clinical Pharmacology Male 1969 Dr.Med 1999 6<br />
11. Allen Kaasik Sr. Researcher 1,00 Toxicology Male 1970 Dr.Med 1998 7<br />
12. Anti Kalda Sr. Researcher 1,00 Toxicology Male 1965 Dr.Med 1999 5<br />
13. Reet Rander Researcher 1,00 Clinical Pharmacology Female 1973 M.Sc 1998 3<br />
14. Katrin Pruus Researcher 1,00 Pharmacology Female 1970 M.Sc 2000 3<br />
15. Alar Irs Researcher 0,50 Clinical Pharmacology Male 1973 3<br />
16. Külli Jaakko Researcher 0,50 Toxicology Female 1976 M.Sc 2000 2<br />
17. Maie Toomsalu Sr. Technical staff 1,00 Female 1952 14<br />
18. Hiie Sarv Sr. Technical staff 1,00 Female 1952 M.Sc 1976 20<br />
19. Annika Vaarmann Technical staff 1,00 Female 1975 B.Sc 1999 1<br />
20. Ulla Peterson Technical staff 1,00 Female 1947 33<br />
21. Sirje Henno Technical staff 0,50 Female 1952 29<br />
22. Oili Suvi Secretary 0,50 Female 1957 25<br />
1 Dr.Sci is a degree <strong>of</strong> <strong>the</strong> Former Soviet Union, which corresponds to a Dr.Med<br />
63
APPENDIX I-VIII<br />
Curriculum Vitae <strong>of</strong> <strong>the</strong> staff<br />
PHARMACOLOGY<br />
ALLIKMETS, LEMBIT Pr<strong>of</strong>essor and Chairman, <strong>Department</strong> <strong>of</strong> Pharmacology, University <strong>of</strong> Tartu Born:<br />
June 18, 1936, male, Estonia, Tartu, 3 Taara Str. Education:1960 – graduated cum laude from <strong>the</strong><br />
Medical faculty <strong>of</strong> <strong>the</strong> University <strong>of</strong> Tartu ; 1960-1963 – postgraduate studies in pharmacology at <strong>the</strong><br />
Institute <strong>of</strong> Experimental Medicine in Leningrad, Ph.D. in 1963; 1963-1967 – Research Fellow at <strong>the</strong><br />
Division <strong>of</strong> Experimental Pathology and Pharmacology in <strong>the</strong> Central Medical Research Laboratories,<br />
University <strong>of</strong> Tartu; 1966-1967 – Postdoctoral Fellow at <strong>the</strong> Yale University (USA); 1968-1971 – Director<br />
<strong>of</strong> <strong>the</strong> Division <strong>of</strong> Experimental Pathology and Pharmacology, University <strong>of</strong> Tartu; since 1971 –<br />
Pr<strong>of</strong>essor <strong>of</strong> Pharmacology; from 1972 – Chairman <strong>of</strong> <strong>the</strong> <strong>Department</strong> <strong>of</strong> Pharmacology, University <strong>of</strong><br />
Tartu, 1978-1979 – Visiting Pr<strong>of</strong>essor at <strong>the</strong> Universities <strong>of</strong> Wisconsins and New York University, USA;<br />
1975-1984 and 1989-1994 – Dean <strong>of</strong> Medical Faculty, University <strong>of</strong> Tartu; 1990 – (4 months) Fulbright<br />
lecturer at Yale University, USA, in 1995 – 3 months on TEMPUS stipendium in German Universities.<br />
Scientific degrees: M.D., Ph.D., D.Sc. D.h.c., University Pr<strong>of</strong>essor Administrative experience:<br />
Chairman <strong>of</strong> departments 1967-2001, vice Dean <strong>of</strong> <strong>the</strong> faculty 1973-75, Dean <strong>of</strong> <strong>the</strong> faculty (14 years),<br />
chairman <strong>of</strong> councels and societies Scietific awards and honours: 1975 – Award from <strong>the</strong> Government<br />
<strong>of</strong> Soviet Estonia for Scientific Achievements in Medical Research; 1976 – Merited Scientist <strong>of</strong> <strong>the</strong> Soviet<br />
Estonia; 1983 – Award <strong>of</strong> Krakov from <strong>the</strong> USSR Academy <strong>of</strong> Medicine; 1994 – Doctor honoris<br />
causa in Lublin. Main fields <strong>of</strong> scientific interests: Molecular mechanism <strong>of</strong> action <strong>of</strong> psychoactive<br />
drugs: neuroleptics, tranquilizers, antidepressants and stress- prodective drugs. Member <strong>of</strong> societies:<br />
6 international and 5 National Scientific Societies, chairman <strong>of</strong> Ethical Committee. Scientific<br />
achievements: Participation in <strong>the</strong> development <strong>of</strong> 4 new psychotropic drugs resulting in <strong>the</strong>ir acceptance<br />
for clinical use in USSR From 1981-90 Head coordinator <strong>of</strong> <strong>the</strong> Programme <strong>of</strong> Psychopharmacological<br />
Research at <strong>the</strong> USSR Academy <strong>of</strong> Medical Sciences Organizer <strong>of</strong> 6 All-Union symposias in<br />
neuro-psychopharmacology in Tartu Member <strong>of</strong> <strong>the</strong> Editorial Board <strong>of</strong> 3 scientific journals <strong>of</strong> experimental<br />
medicine Scientific superviser <strong>of</strong> 18 postgraduates and Research Fellow applying for <strong>the</strong>ir<br />
scientific degrees (Ph.D., D.Sc.) Publications: 1961-2001 12 books, 310 papers, 110 conference<br />
materials and abstracts<br />
ZHARKOVSKY, ALEXANDER Date <strong>of</strong> birth: 31.01.1950 Gender: M Citizenship: Estonian Address:<br />
Pohla Street 13-2, 50411 Tartu, Estonia Current position: Pr<strong>of</strong>essor <strong>of</strong> Pharmacology & Drug Toxicology;<br />
Chair <strong>of</strong> Pharmaco<strong>the</strong>rapy and Drug Toxicology, <strong>Department</strong> <strong>of</strong> Pharmacology, University <strong>of</strong><br />
Tartu Educational history: High school (Tartu University) graduation 1968-1974, MD degree, 1974<br />
Postgraduate School <strong>of</strong> Pharmacology 1974-1978, Ph.D. in Pharmacology, 1978 Research Fellow,<br />
<strong>Department</strong> <strong>of</strong> Pharmacology, Lublin Medical Academy, Poland, 1979 Wellcome Trust Research Fellowship<br />
Award: Psychopharmacology Research Unit, UMDS, Guy's Hospital, London University, UK,<br />
1989-1991 Sigrid Juselius Foundation Research Fellowship Award: <strong>the</strong> Division <strong>of</strong> Pharmacology <strong>Department</strong><br />
<strong>of</strong> Pharmacy, Helsinki University, Helsinki, Finland, 1991-1992 Wenner Green Foundation<br />
Fellowship at <strong>the</strong> <strong>Department</strong> <strong>of</strong> Drug Dependence Research, Karolinska Institute, Stockholm, Sweden<br />
1993 8. Membership in Sientific Societies: Estonian Pharmacological Society since 1976;<br />
European Behavioral Pharmacology Society since 1988 Member <strong>of</strong> Editorial Board <strong>of</strong> Naunyn<br />
Schmiedebrerg's Archives <strong>of</strong> Pharmacology since 1993 Member <strong>of</strong> European Society on Biomedical<br />
Research <strong>of</strong> Alcoholism since 1993 Member <strong>of</strong> <strong>the</strong> British Psychopharmacology Society, 1998; Estonian<br />
Toxicological Society 1988 9. Academic degrees (with year and university): MD - University <strong>of</strong><br />
Tartu, 1974; PhD- University <strong>of</strong> Tartu, 1979; D.Sci.- University <strong>of</strong> Tartu, 1988 10. Employment and<br />
pr<strong>of</strong>essional experience: Researcher, University <strong>of</strong> Tartu 1978-1979; Assistant, University <strong>of</strong> Tartu,<br />
1979-1980; Senior assistant, University <strong>of</strong> Tartu,1981-1983; Lecturer, University <strong>of</strong> Tartu, 1985-1985<br />
Senior researcher, University <strong>of</strong> Tartu, 1985-1991; Pr<strong>of</strong>essor since 1991 11. Administrative experience:<br />
Member <strong>of</strong> expert panel, Brussel, IV Framework programme; Pr<strong>of</strong>essor selection in Drug Toxicology<br />
(Finland) Pr<strong>of</strong>essor selection in Toxicology (Finland); Member <strong>of</strong> <strong>the</strong> board <strong>of</strong> Grant Evaluation<br />
(Estonian Scientific Foundation): Several local committee activities 12. Honours and awards: -<br />
Wellcome Trust Award for fellowship on <strong>the</strong> studies <strong>of</strong> mechanisms <strong>of</strong> ethanol dependence 1989-<br />
1990; Sigrid Juselius Foundation Award for fellowship 1992 -Wenner Green Foundation Award for<br />
fellowship 1993 13. Membership in academic and scientific societies: Estonian Pharmacological<br />
Society since 1976; European Behavioral Pharmacology Society since 1988; Member <strong>of</strong> Editorial<br />
Board <strong>of</strong> Naunyn Schmiedebrerg's Archives <strong>of</strong> Pharmacology since 1993 Member <strong>of</strong> European Society<br />
on Biomedical Research <strong>of</strong> Alcoholism since 1993; Member <strong>of</strong> <strong>the</strong> British Psychopharmacology<br />
Society, 1998; Member <strong>of</strong> EpharNet-European Network for Teaching in Pharmacology (Estonian Representative)<br />
2000 14. Current research program and grants: -Estonian Science Foundation: Grant<br />
No 3949 (1998-2001) -Ministry <strong>of</strong> higher Education, Project TARFR 0415 (1998-2001) -European<br />
65
SECTION I: APPENDIXES<br />
Community 5th FWP (2001-2003) No: QLG3-CT-2000-01405 15. Supervision <strong>of</strong> dissertations:<br />
K.Cereska (1990) "The role <strong>of</strong> dopamine D1 and D2 receptros in <strong>the</strong> mechanisms <strong>of</strong> action <strong>of</strong> neuroleptics"<br />
PhD T.Kivastik (1996) " Mechanisms <strong>of</strong> Drug addiction: focus on positive reiforcing properties<br />
<strong>of</strong> morphine" PhD P.Pokk (1997) " Stress due to sleep deprivation: <strong>the</strong> role <strong>of</strong> GABA(A) receptor-chlorionophore<br />
complex" PhD E.Eriste (1998) "The neuroprotective actions <strong>of</strong> ketamine isomers" Magistry<br />
Thesis A.Kalda (1999) "Oxygen-glucose deprivation-induced neuronal death and its pharmacological<br />
prevention in cerebellar granule cells" PhD 16. Publications: Current Contents Indexed Journals- 71;<br />
Chapters in monographs- 3; Abstracts - 124 (see attachment)<br />
IRS, ALAR researcher, Institute <strong>of</strong> Pharmacology Date and place <strong>of</strong> birth: July 3 rd , 1973 Tartu, Estonia<br />
Gender: Male Citizenship: Estonian Address: Kaunase ave 55-16, 50706 Tartu, Estonia Education:<br />
Basic training:1997-postgraduate student, Institute <strong>of</strong> Pharmacology, University <strong>of</strong> Tartu Medical Faculty<br />
<strong>of</strong> Tartu University, MD, cum laude Secondary School No 2, present Miina Härma Gymnasium,<br />
Tartu Continuous training: 2000 Pharmacoeconomics in Decision Making, London School <strong>of</strong> Economics,<br />
London, UK 1998 5 th Training Course on Teaching Rational Drug Therapy, Groningen, The<br />
Ne<strong>the</strong>rlands 3 month training in Centre <strong>of</strong> Clinical Pharmacology, Odense University, Denmark Employment:<br />
Present occupation: Research associate, Institute <strong>of</strong> Pharmacology, University <strong>of</strong> Tartu<br />
Head <strong>Department</strong> <strong>of</strong> Registration State Agency <strong>of</strong> Medicines Service record:1997-2000Senior medical<br />
<strong>of</strong>ficer, GCP and Clinical Trials, State Agency <strong>of</strong> Medicines Contract lecturer Institute <strong>of</strong> Pharmacology<br />
University <strong>of</strong> Tartu Honours and Awards: Danish Government Scholarship 1998 Eric Mathiesen<br />
Scholarship, Estonian Student Fund in USA, 1997 Pr<strong>of</strong>essional organisations:Member <strong>of</strong> <strong>the</strong> Estonian<br />
Society <strong>of</strong> Pharmacology, Estonian Medical Association, Estonian Junior Doctors’ Association, Estonian<br />
Society <strong>of</strong> Hypertension Current research programs: Pharmacokinetic interactions <strong>of</strong> newer antidepressants<br />
with drugs affecting cardiovascular system Pharmacoepidemiologic study in treatment <strong>of</strong><br />
hypertension in Estonia Publications: 2 articles in international journals 1 review article in a national<br />
journal 6 conference abstracts<br />
KAASIK, ALLEN, senior researcher at <strong>Department</strong> <strong>of</strong> Pharmacology, University <strong>of</strong> Tartu Date <strong>of</strong> birth:<br />
August 23, 1970 Gender: male. Citizenship: Estonian. Address: Ravila 19, 50411 Tartu Estonia.<br />
Educational history: Tallinn Secondary School N 5 Faculty <strong>of</strong> Biology (Biochemistry), University <strong>of</strong><br />
Tartu M.Sci studies at <strong>the</strong> <strong>Department</strong> <strong>of</strong> Pathophysiology, University <strong>of</strong> Tartu and at Institute <strong>of</strong><br />
Biomedicine, University <strong>of</strong> Helsinki Postgraduate Ph.D. studies at <strong>the</strong> <strong>Department</strong> <strong>of</strong> Pathophysiology,<br />
Univ Tartu and at Institute <strong>of</strong> Biomedicine, University <strong>of</strong> Helsinki Academic degrees: M.Sci. in biomedicine<br />
(1994) Ph.D. in pathophysiology (1998), University <strong>of</strong> Tartu Employment and pr<strong>of</strong>essional<br />
experience: 1994-1997 – lecturer, Dept Pathophysiology, University <strong>of</strong> Tartu 1997-1999-2000 (10<br />
months) – researcher, Laboratory <strong>of</strong> Cellular and Molecular Cardiology, University <strong>of</strong> Paris-Sud, 1998-<br />
1999 – researcher, Dept Pharmacology, University <strong>of</strong> Tartu senior researcher, Dept Pharmacology,<br />
University <strong>of</strong> Tartu Administrative experience: Honors and awards: Membership in academic and<br />
scientific societies: Estonian Society <strong>of</strong> Pharmacology and Estonian Society <strong>of</strong> Biochemistry. Current<br />
research program and participation in grants: Estonian Science Foundation: “New perspectives in<br />
pharmacology <strong>of</strong> neurodegenerative disorders. Ministry <strong>of</strong> Education: “Drug dependence and neuronal<br />
death. Molecular mechanisms and pharmacological prevention ". Ministry <strong>of</strong> Education: "The mechanism<br />
<strong>of</strong> neuroprotective action <strong>of</strong> dehydroepiandrosterone" European Union: "Progressive myoclonic<br />
epilepsy and neuronal apoptosis. A genetic, molecular, biological, biochemical and pharmacological<br />
approach to cystatin B and cysteine proteases". Supervision <strong>of</strong> dissertations: Publications: articles<br />
in international scientific journals – 12<br />
KALDA, ANTI Current position: senior researcher, <strong>Department</strong> <strong>of</strong> Pharmacology, University <strong>of</strong> Tartu.<br />
Date <strong>of</strong> birth: July 23, 1965. Gender: male. Citizenship: Estonian. Address: Ravila 19, 50411 Tartu<br />
Estonia. Educational history: Tallinn Secondary School N. 47 (1983), Medical Faculty <strong>of</strong> <strong>the</strong> University<br />
<strong>of</strong> Tartu, M.D. upon graduation (1983 – 1991), postgraduate studies at <strong>the</strong> <strong>Department</strong> <strong>of</strong> Neurology,<br />
Tartu University (1992 – 1997). Academic degrees: Medical doctor Tartu University (1991),<br />
Ph.D. in pharmacology (1999). Employment and pr<strong>of</strong>essional experience: Research student in <strong>Department</strong><br />
<strong>of</strong> Clinical Neuroscience, Karolinska Institute, Sweden (6 month, 1994). Researcher in <strong>Department</strong><br />
<strong>of</strong> Pharmacology, Tartu University (1998 – 2000). Senior researcher in <strong>Department</strong> <strong>of</strong> Pharmacology,<br />
Tartu University. Administrative experience: Honors and awards: Membership in academic<br />
and scientific societies: membership <strong>of</strong> Estonian Society <strong>of</strong> Pharmacology and Estonian Society<br />
<strong>of</strong> Toxicology. Current research program and grants: Estonian Science Foundation: Grant No. 3949<br />
(1999-2001) “New perspectives in pharmacology <strong>of</strong> neurodegenerative disorders. Ministry <strong>of</strong> higher<br />
Education: TARFR grant nr. 0415 (1998-2002) “Drug dependence and neuronal death. Molecular<br />
mechanisms and pharmacological prevention.” European Community 5 th FWP No. QLG3-CT-2000-<br />
01405 (2001 – 2003) “Progressive myoclonic epilepsy and neuronal apoptosis. A genetic, molecular<br />
66
PHARMACOLOGY<br />
biological, biochemical and pharmacological approach to cystatin B and cysteine proteases.” Supervision<br />
<strong>of</strong> dissertations: Publications: articles – 9, abstracts 18.<br />
PÄHKLA, REIN Associate Pr<strong>of</strong>essor (Docent) 2. Date <strong>of</strong> birth: 27.04.1966 3. Gender: Male 4. Citizenship:<br />
Estonian 5. Address: Ravila 19, 50411 Tartu, Estonia 6. Educational history: 1984 Jõgeva<br />
Secondary School - University <strong>of</strong> Tartu, Medical Faculty 7. Academic degrees: 1997 - PhD topic <strong>of</strong><br />
dissertation: "Pharmacological studies <strong>of</strong> pinoline", University <strong>of</strong> Tartu 8. Employment and pr<strong>of</strong>essional<br />
experience: - 1997 postgraduate PhD student in Dept. <strong>of</strong> Pharmacology, University <strong>of</strong> Tartu -<br />
1998 assistant in Dept. <strong>of</strong> Pharmacology 1998 - senior assistant in Dept. <strong>of</strong> Pharmacology – Docent<br />
(associate pr<strong>of</strong>essor) in Dept. <strong>of</strong> Pharmacology 9. Administrative experience: – chairman <strong>of</strong> Estonian<br />
Society <strong>of</strong> Pharmacology – chairman <strong>of</strong> clinical pharmacology, Institute <strong>of</strong> Pharmacology – head,<br />
post-graduate specialisation course in clinical pharmacology 10. Honours and awards: – 11. Membership<br />
in academic and scientific societies: - Estonian Society <strong>of</strong> Pharmacology 12. Current research<br />
program and grants: Clinical pharmacokinetic studies. Grant 4428 <strong>of</strong> Estonian Science<br />
Foundation: Optimisation <strong>of</strong> drug treatment regimens based on <strong>the</strong> results <strong>of</strong> pharmacogenetic and<br />
pharmacokinetic studies. 13. Supervision <strong>of</strong> dissertations: Currently supervisor <strong>of</strong> one MsC student<br />
14. Publications: Number <strong>of</strong> publications 42, from <strong>the</strong>se 14 full-length articles in international scientific<br />
journals<br />
POKK, PAAVO senior teaching assistant <strong>of</strong> <strong>Department</strong> <strong>of</strong> Pharmacology, University <strong>of</strong> Tartu Date <strong>of</strong><br />
birth:18.03.1966 in Tartu, Republic <strong>of</strong> Estonia Gender: Male Citizenship: Estonian Address: Räägu<br />
12, Tartu, Estonia Educational history: (1) 1973-1984 Tartu Secondary School No 2.; (2) 1984 -<br />
1990 student, University <strong>of</strong> Tartu, Faculty <strong>of</strong> Medicine (3) 1990 - 1994 postgraduate student ,University<br />
<strong>of</strong> Tartu, Faculty <strong>of</strong> Medicine, <strong>Department</strong> <strong>of</strong> Pharmacology,. Academic degrees: (1) Physician<br />
(M.D.), June 1990, University <strong>of</strong> Tartu; (2) Doctor <strong>of</strong> medical sciences (Ph.D.), January 8th, 1997, University<br />
<strong>of</strong> Tartu. Employment and pr<strong>of</strong>essional experience: (1) 1997 - 1999 assistant, <strong>Department</strong><br />
<strong>of</strong> Pharmacology, University <strong>of</strong> Tartu; (2) 1999 - senior teaching assistant, <strong>Department</strong> <strong>of</strong> Pharmacology,<br />
University <strong>of</strong> Tartu; (3) 1999-2000 postdoctoral fellow, <strong>Department</strong> <strong>of</strong> Pharmacology, University <strong>of</strong><br />
Tartu; (4) 2000 - senior teaching assistant, <strong>Department</strong> <strong>of</strong> Pharmacology, University <strong>of</strong> Tartu. Administrative<br />
experience: (1) Member <strong>of</strong> Organizing Committee <strong>of</strong> <strong>the</strong> Rudolf Buchheim Conference in<br />
Neuropharmacology (May, 1995); (2) Member <strong>of</strong> Organizing Committee <strong>of</strong> <strong>the</strong> 2nd Baltic Regional<br />
Meeting <strong>of</strong> Biological Psychiatry (June, 2001). Board member <strong>of</strong> Estonian Pharmacological Society<br />
Honours and awards: (1) European College <strong>of</strong> Neuropsychopharmacology (ECNP) Fellowship Award<br />
1999, presented in London, England at <strong>the</strong> 12th Congress <strong>of</strong> ECNP. Memberships: (1) Member <strong>of</strong><br />
Estonian Pharmacological Society (member <strong>of</strong> <strong>the</strong> Board); (2) Member <strong>of</strong> Estonian Laboratory Animal<br />
Science Association. Current research program and grants: collaborator in following scientific projects:<br />
Drug and alcohol addiction studies Supervision <strong>of</strong> dissertations: - Publications: Peer-reviewed<br />
international full-lengths articles: 19; Peer-reviewed Estonian full-lengths articles: 4; Conference abstracts:<br />
34 Teaching manuals: 2<br />
JAAKO, KÜLLI Present position: Researcher (0.5 staff). <strong>Department</strong> <strong>of</strong> Pharmacology, University <strong>of</strong><br />
Tartu. Postgraduate student in <strong>the</strong> <strong>Department</strong> <strong>of</strong> Pharmacology and Toxicology. 2.Date <strong>of</strong> birth:<br />
04.12.1976 3.Gender: Female. 4.Citizenship: Estonian. 5.Address: Vaikne 18, 50303 Tartu, Estonia.<br />
6.Educational history: Hugo Treffner’s Gymnasium in Tartu. – 2000 Medical faculty <strong>of</strong> University <strong>of</strong><br />
Tartu. <strong>Department</strong> <strong>of</strong> Pharmacy. April 2000 I have worked in <strong>the</strong> Division <strong>of</strong> Neurology, University <strong>of</strong><br />
Kuopio (Finland) 7.Academic degrees: Baccalaureate. 8.Employment and pr<strong>of</strong>essional experience:<br />
October 2000 to present – researcher. 9.Administrative experience: none. 10. Honors and<br />
awards: III award from Ministry <strong>of</strong> Education 11.Membership in academic and scientific societies:<br />
Estonian Society <strong>of</strong> Pharmacology. 12.Current research programs and grants: ”Drug dependence<br />
and neuronal death. Molecular mechanisms and pharmacological prevention”: Ministry <strong>of</strong> higher Education:<br />
TARFR grant No.0415 (1998-2002) European Community 5 th FWP No. QLG3-CT-2000-01405<br />
(2001-2003). “Progressive myoclonic epilepsy and neuronal apoptosis. A genetic, molecular biological,<br />
biochemical and pharmacological approach to cystatin B and cysteine proteases.” 13 Supervision <strong>of</strong><br />
dissertations: 14.Publications: articles- 1; abstracts-5<br />
MATTO, VALLO, senior teaching assistant <strong>of</strong> <strong>Department</strong> <strong>of</strong> Pharmacology, University <strong>of</strong> Tartu Date<br />
<strong>of</strong> birth:04.02.1969 in Tallinn, Republic <strong>of</strong> Estonia Gender: Male Citizenship: Estonian Address:<br />
Aardla St. 21-14, 50112 Tartu, Estonia Educational history:(1) 1976-1987 Tallinn 42th Secondary<br />
School, primary and high school pupil; (2) September 1987 - June 1991 University <strong>of</strong> Tartu, Faculty <strong>of</strong><br />
Medicine, undergraduate student; (3) August 1991- January 1992 University <strong>of</strong> Helsinki, Faculty <strong>of</strong><br />
Medicine, undergraduate student; (4) January 1992 - June 1993 University <strong>of</strong> Tartu, Faculty <strong>of</strong> Medicine,<br />
undergraduate student; (5) June 1993 - graduated from <strong>the</strong> Faculty <strong>of</strong> Medicine, University <strong>of</strong><br />
67
SECTION I: APPENDIXES<br />
Tartu as a physician; (6) September 1993 - January 1998 University <strong>of</strong> Tartu, Faculty <strong>of</strong> Medicine, <strong>Department</strong><br />
<strong>of</strong> Pharmacology, postgraduate student. Academic degrees:(1) Physician (M.D.), June 1993,<br />
University <strong>of</strong> Tartu (2) Doctor <strong>of</strong> medical sciences (Ph.D.), June 3rd, 1998 (cum laude), University <strong>of</strong><br />
Tartu Employment and pr<strong>of</strong>essional experience: (1)1989-1991 and 1992-1993 part-time nurse in<br />
Tartu Psychiatric Hospital, Children’s <strong>Department</strong>. (2) 1993-1997 part-time assistant, <strong>Department</strong> <strong>of</strong><br />
Pharmacology, University <strong>of</strong> Tartu (3) 1997-1998 assistant, <strong>Department</strong> <strong>of</strong> Pharmacology, University<br />
<strong>of</strong> Tartu (4) 1999 senior assistant, <strong>Department</strong> <strong>of</strong> Pharmacology, University <strong>of</strong> Tartu (5) 1999-2000<br />
postdoctoral fellow, <strong>Department</strong> <strong>of</strong> Pharmacology, University <strong>of</strong> Tartu (6) March 1999 – March 2000<br />
post-doc researcher, Division <strong>of</strong> Pharmacology and Toxicology, <strong>Department</strong> <strong>of</strong> Pharmacy, University<br />
<strong>of</strong> Helsinki, Finland (7) – 2001 senior teaching assistant, <strong>Department</strong> <strong>of</strong> Pharmacology, University <strong>of</strong><br />
Tartu Administrative experience: (1) Member <strong>of</strong> Organizing Committee <strong>of</strong> <strong>the</strong> Rudolf Buchheim<br />
Conference in Neuropharmacology (May, 1995). Honours and awards: (1) Winner <strong>of</strong> <strong>the</strong> scholarship<br />
<strong>of</strong> <strong>the</strong> “Ants and Maria Silvere and Sigfried Pant Memorial Scholarship at Tartu University Foundation”,<br />
1997 (2) The European Neuropeptide Club Award, 1997 (3) 3rd student prize <strong>of</strong> <strong>the</strong> competition organised<br />
by The Ministry <strong>of</strong> Education, The Republic <strong>of</strong> Estonia, 1997 (4) Lundbeck Eesti AS 1998<br />
award <strong>of</strong> psychopharmacology and biological psychiatry (5) European College <strong>of</strong> Neuropsychopharmacology<br />
(ECNP) Fellowship Award 2000, presented in Munich, Germany at <strong>the</strong> 13th Congress <strong>of</strong><br />
ECNP (6) Poster prize at <strong>the</strong> 2nd Baltic Regional Meeting in Biological Psychiatry Vilnius, Lithuania,<br />
2000 Memberships: (1) Member <strong>of</strong> Estonian Pharmacological Society, Estonian Laboratory Animal<br />
Science Association (member <strong>of</strong> <strong>the</strong> Board, 1997-1998), (3) Estonian Society <strong>of</strong> Biological Psychiatry<br />
(secretary from 2000) Current research program and grants: collaborator in following scientific projects:<br />
The mechanism <strong>of</strong> affective disorders and <strong>the</strong> kinetic and mechanism <strong>of</strong> action <strong>of</strong> <strong>the</strong> novel antidepressants,<br />
principal investigator chair <strong>of</strong> pharmacology, Pr<strong>of</strong>essor L. Allikmets (2) Grant 3379: Elucidation<br />
<strong>of</strong> <strong>the</strong> mechanism <strong>of</strong> anxiogenic/anxiolytic action <strong>of</strong> antidepressants, principal investigator<br />
chair <strong>of</strong> pharmacology, Pr<strong>of</strong>essor L. Allikmets Supervision <strong>of</strong> dissertations: (1) 2000, Bachelor’s<br />
dissertation: Ruth Rudissaar, “The role <strong>of</strong> 5-HT3 receptors in apomorphine-induced aggressive behaviour<br />
in rats” Publications: Peer-reviewed international full-lengths articles (incl. Accepted papers):<br />
31 Peer-reviewed Estonian full-lengths articles (incl. accepted papers): 3 Conference abstracts: 43<br />
KIVASTIK, TOOMAS Present position: senior teaching assistant (temporarily at 0.5 staff); <strong>Department</strong> <strong>of</strong><br />
Pharmacology, University <strong>of</strong> Tartu, Project manager, Clinicum, University <strong>of</strong> Tartu Date <strong>of</strong> birth:<br />
31.01.1965 Gender: male Citizenship: Estonian Address: Ravila 19, 51014 Tartu, Estonia Educational<br />
history: 1983 Tartu Secondary School N 5 1984 – 1991 Medical Faculty <strong>of</strong> <strong>the</strong> University <strong>of</strong><br />
Tartu, Medical doctor upon graduation 1991 – 1996 Postgraduate studies at <strong>the</strong> <strong>Department</strong> <strong>of</strong> Pharmacology,<br />
University <strong>of</strong> Tartu, During 1992 – 1994 worked alltoge<strong>the</strong>r 9 months in <strong>the</strong> Division <strong>of</strong><br />
Pharmacology and Toxicology, <strong>Department</strong> <strong>of</strong> Pharmacy, University <strong>of</strong> Helsinki (Finland) as a visiting<br />
postgraduate student – 1999 post-doctoral fellow at <strong>the</strong> <strong>Department</strong> <strong>of</strong> Clinical Neuroscience, Division<br />
<strong>of</strong> Alcohol and Drug Dependence Research, Karolinska Institute (Stockholm, Sweden); Academic<br />
degrees: PhD, 1996, University <strong>of</strong> Tartu Employment and pr<strong>of</strong>essional experience: to 2000 –<br />
teaching assistant at <strong>the</strong> <strong>Department</strong> <strong>of</strong> Pharmacology, University <strong>of</strong> Tartu; March 2000 to present –<br />
senior teaching assistant at <strong>the</strong> Dept. <strong>of</strong> Pharmacology, University <strong>of</strong> Tartu September 2000 to present<br />
– project manager <strong>of</strong> <strong>the</strong> feasibility study <strong>of</strong> Tartu University Clinicum Administrative experience:<br />
project manager <strong>of</strong> <strong>the</strong> feasibility study <strong>of</strong> Tartu University Clinicum (September 2000 to present)<br />
Honours and awards: Membership in academic and scientific societies: Estonian Society <strong>of</strong><br />
Pharmacology, Estonian Society <strong>of</strong> Biological Psychiatry, Society for Neuroscience Current research<br />
programs and grants: Mechanisms <strong>of</strong> drug addiction: role <strong>of</strong> brain dopaminergic glutamatergic and<br />
GABA-ergic systems. Current grants: one Supervision <strong>of</strong> dissertations: none Publications: articles<br />
– 10; abstracts 20<br />
ZHARKOVSKAJA, TAMARA docent <strong>of</strong> <strong>Department</strong> <strong>of</strong> Pharmacology 2. Date <strong>of</strong> birth:10th February 1954,<br />
Irkutsk province, Russian Federation 3. Gender: Female 4. Citizenship: Estonia 5. Address: Tartu,<br />
Pohla 13-2 6. Educational history: Secondary School <strong>of</strong> Sheberta Medical Institute <strong>of</strong> Irkutsk, Faculty<br />
<strong>of</strong> Pharmacy, 1976 7. Academic degrees (with year and university): PhD 1982, <strong>Department</strong> <strong>of</strong> Pharmacology<br />
8. Employment and pr<strong>of</strong>essional experience: Postgraduate fellowship 1976-1980 Scientific<br />
researcher <strong>of</strong> Institute <strong>of</strong> General and Molecular Pathology 1980-1985 Senior assistant <strong>of</strong> <strong>the</strong> <strong>Department</strong><br />
<strong>of</strong> Pharmacology 1985-1988, docent from 1988 9. Administrative experience: Participating in<br />
organizing scientific conferences 10. Honours and awards: - 11. Membership in academic and scientific<br />
societies: Estonian Society <strong>of</strong> Pharmacology 12. Current research program and grants:<br />
Estonian Science Foundation: “New perspectives in pharmacology <strong>of</strong> neurodegenerative disorders.<br />
Ministry <strong>of</strong> Education: “Drug dependence and neuronal death. Molecular mechanisms and pharmacological<br />
prevention ". Ministry <strong>of</strong> Education: "The mechanism <strong>of</strong> neuroprotective action <strong>of</strong> dehydroepiandrosterone"<br />
European Union: "Progressive myoclonic epilepsy and neuronal apoptosis. A genetic,<br />
68
PHARMACOLOGY<br />
molecular, biological, biochemical and pharmacological approach to cystatin B and cysteine proteases".<br />
13. Supervision <strong>of</strong> dissertations: - 14. Publications: 64<br />
OTTER, MARGAREETE-HELGE docent <strong>of</strong> <strong>Department</strong> <strong>of</strong> Pharmacology 2. Date <strong>of</strong> birth:9th September<br />
1937, Tartu 3. Gender: Female 4. Citizenship: Estonia 5. Address: Tartu, Ujula 23, 51008 6. Educational<br />
history: II Secondary School <strong>of</strong> Tartu, 1954 Medical Faculty <strong>of</strong> Tartu, 1959 7. Academic degrees<br />
(with year and university): PhD 1968, Institute <strong>of</strong> Experimental Biology 8. Employment and<br />
pr<strong>of</strong>essional experience: Healthcare <strong>Department</strong> <strong>of</strong> Tartu, Estonian Agricultural Academy 1959-1964<br />
Postgraduate fellowship 1964-1967 Scientific researcher <strong>of</strong> Institute <strong>of</strong> Experimental Biology, University<br />
<strong>of</strong> Tartu 1967-1977 Scientific researcher <strong>of</strong> Laboratory <strong>of</strong> Psychopharmacology 1977-1981 <strong>Department</strong><br />
<strong>of</strong> Pharmacology, University <strong>of</strong> Tartu 1981-2001, docent from 1986 9. Administrative experience:<br />
Participation in organizations <strong>of</strong> scientific conferences Member <strong>of</strong> Board <strong>of</strong> Estonian Pharmacological<br />
Society 10. Honours and awards: - 11. Membership in academic and scientific societies:<br />
Member <strong>of</strong> Estonian Society <strong>of</strong> Pharmacology, Estonian Physiological Society 12. Current research<br />
program and grants: Participation in grant No 3379, Estonian Science Foundation : Research<br />
on antidepressants 13. Supervision <strong>of</strong> dissertations: 2 supervision <strong>of</strong> bacalaureus dissertations<br />
14. Publications: 397<br />
69
PHYSIOLOGY<br />
<strong>Name</strong> <strong>of</strong> <strong>Department</strong>: <strong>Department</strong> <strong>of</strong> Physiology<br />
Head <strong>of</strong> <strong>the</strong> <strong>Department</strong>: Pr<strong>of</strong>essor Eero Vasar<br />
<strong>Name</strong> <strong>of</strong> Chair: Physiology<br />
Head <strong>of</strong> Chair: Pr<strong>of</strong>essor Eero Vasar<br />
Subject codes: ARFS.01.030; ARFS.01.037; ARFS.01.005; ARFS.01.011;<br />
ARFS.01.018; ARFS.01.020; ARFS.01.028; ARFS.01.034;<br />
ARFS.01.038; ARFS.01.039; ARFS.01.040; ARFS.01.044;<br />
ARFS.01.045; ARFS.01.049<br />
I. CONTENT OF THE TEACHING<br />
1. Describe shortly <strong>the</strong> main study and student evaluation methods applied at<br />
<strong>the</strong> department.<br />
Two major subjects are taught at <strong>the</strong> <strong>Department</strong> <strong>of</strong> Physiology: Biophysics<br />
and Human Physiology. The teaching <strong>of</strong> Biophysics takes place during <strong>the</strong> 2 nd<br />
Semester, whereas Human Physiology is taught during <strong>the</strong> 3 rd and 4 th Semester.<br />
Our medical school follows <strong>the</strong> classical way <strong>of</strong> medical studies. Main<br />
forms <strong>of</strong> teaching in Biophysics and Human Physiology are lectures, seminars<br />
and laboratory works. The course <strong>of</strong> Biophysics consists <strong>of</strong> 8 lectures and 12<br />
practical works, altoge<strong>the</strong>r 2 credits (48 hours <strong>of</strong> auditory work and 32 hours <strong>of</strong><br />
independent work). The students have to pass during <strong>the</strong> studies two tests<br />
and <strong>the</strong> course will be ended by <strong>the</strong> exam. The course <strong>of</strong> Human Physiology<br />
consists <strong>of</strong> 32 lectures, 6 seminars and 32 practical works, altoge<strong>the</strong>r 8 credits<br />
(190 hours <strong>of</strong> auditory work and 130 hours <strong>of</strong> independent work). The participation<br />
<strong>of</strong> students in seminars and laboratory classes is compulsory. From 32<br />
practical works 24 are based on studies in humans (blood, respiratory, cardiovascular,<br />
kidney and molecular physiology), three are <strong>the</strong> computer-aided<br />
simulations (studies on <strong>the</strong> muscle and nerve tissue) and one is based on<br />
animal experiments (scoring <strong>of</strong> animal behaviour from <strong>the</strong> video recordings).<br />
Four practical works are based on <strong>the</strong>oretical discussions (endocrinology). Six<br />
seminars are devoted to <strong>the</strong> topics <strong>of</strong> integrative physiology (regulation <strong>of</strong><br />
body temperature, osmotic pressure, acid-base balance and so forth). The<br />
knowledge and skills <strong>of</strong> students are assessed at <strong>the</strong> end <strong>of</strong> each practical<br />
work. Moreover, <strong>the</strong> students have to pass 10 written tests, dedicated to <strong>the</strong><br />
different topics <strong>of</strong> physiology. The knowledge <strong>of</strong> students is also assessed in<br />
<strong>the</strong> end <strong>of</strong> each seminar. Finally, <strong>the</strong>y have to pass <strong>the</strong> written exam. The<br />
exam consists <strong>of</strong> three parts: short questions (5 points), questions about different<br />
topics <strong>of</strong> physiology (40 points) and one extended question about integrative<br />
physiology (15 points). Altoge<strong>the</strong>r one can get 60 points from <strong>the</strong> written<br />
exam. However, a final estimate also contains <strong>the</strong> results <strong>of</strong> written tests<br />
(30 points) and seminars (10 points). Therefore, <strong>the</strong> maximal amount that one<br />
can get is 100 points. The final outcome is expressed according to an <strong>of</strong>ficial<br />
rule <strong>of</strong> <strong>the</strong> university, ranging from A (91-100 points) to F grade (less than 51<br />
points).<br />
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SECTION I: SELF-EVALUATION<br />
72<br />
In addition to <strong>the</strong>se major topics several optional courses are taught in <strong>the</strong><br />
<strong>Department</strong> <strong>of</strong> Physiology. These courses are following: Research methods in<br />
respiratory physiology (0.5 credits), Physiology <strong>of</strong> nutrition (1 credit), Consciousness<br />
– interdisciplinary approach (1 credit), Diffuse neuroendocrine<br />
system (0.5 credits), Basic neuroscience (1 credit), Neurophysiology <strong>of</strong> pain (1<br />
credit), Modern research methods in neurobiology (4 credits). The optional<br />
courses are consisting <strong>of</strong> lectures and seminars, and for successful passing <strong>of</strong><br />
<strong>the</strong>se courses <strong>the</strong> students have to write an essay and test. The exception is<br />
<strong>the</strong> Modern methods <strong>of</strong> neurobiology, where <strong>the</strong> students have to participate in<br />
seminars, to make <strong>the</strong> presentation about <strong>the</strong> scientific papers and to perform,<br />
under <strong>the</strong> supervising <strong>of</strong> scientific staff <strong>of</strong> a department, <strong>the</strong> experiments on<br />
laboratory animals.<br />
There are also several courses for <strong>the</strong> postgraduate students: Basic neuroscience<br />
(2 credits), Neurophysiology (2 credits), Biology <strong>of</strong> nerve cell (1<br />
credit), Modern approaches in neuroscience (6 credits), Neurobiology <strong>of</strong> emotions<br />
(2 credits), Neural correlates <strong>of</strong> consciousness (1 credit)<br />
2. How have <strong>the</strong> aims and objectives described in <strong>the</strong> curriculum changed<br />
during <strong>the</strong> past five years?<br />
During <strong>the</strong> past five years <strong>the</strong> main objectives <strong>of</strong> Human Physiology have not<br />
substantially changed. We are trying to follow several objectives in <strong>the</strong> teaching<br />
<strong>of</strong> Human Physiology.<br />
• General principles <strong>of</strong> body functioning: physical, chemical and informational<br />
bases <strong>of</strong> life processes.<br />
• Main regulatory principles <strong>of</strong> body functioning.<br />
• Overview <strong>of</strong> functions <strong>of</strong> <strong>the</strong> organ systems.<br />
• Introduction and training <strong>of</strong> classical and modern study methods in physiology.<br />
• Also our task is to underline <strong>the</strong> integration <strong>of</strong> physiological functions characterising<br />
<strong>the</strong> performance <strong>of</strong> <strong>the</strong> human body as a whole in health. For<br />
obtaining <strong>of</strong> this objective we have taken following steps:<br />
• We have included an essay question about <strong>the</strong> integrative physiology into<br />
<strong>the</strong> exam. We have established <strong>the</strong> seminars for a smaller group <strong>of</strong> students<br />
(8-12) to train <strong>the</strong>ir biomedical thinking and problem solving abilities.<br />
• During <strong>the</strong> last five years we have re-established <strong>the</strong> teaching <strong>of</strong> Biophysics<br />
at <strong>the</strong> <strong>Department</strong> <strong>of</strong> Physiology. In many universities this course is<br />
obligatory for passing <strong>of</strong> Human Physiology and, <strong>the</strong>refore, after many<br />
years <strong>the</strong> <strong>Department</strong> <strong>of</strong> Physiology has taken <strong>the</strong> co-ordination <strong>of</strong> this topic<br />
in <strong>the</strong> University <strong>of</strong> Tartu. The aim <strong>of</strong> a course <strong>of</strong> Biophysics is to study <strong>the</strong><br />
physical processes related to <strong>the</strong> functioning <strong>of</strong> living organism.<br />
• Moreover, taking advantage from <strong>the</strong> molecular physiology we have included<br />
into <strong>the</strong> practical works a study <strong>of</strong> gene polymorphism and discussing<br />
<strong>the</strong> role <strong>of</strong> <strong>the</strong>se genetic differences for <strong>the</strong> peculiarities <strong>of</strong><br />
physiological functions in humans. Currently we have include a study <strong>of</strong><br />
<strong>the</strong> polymorphism <strong>of</strong> angiotensin-converting enzyme (ACE) gene.
PHYSIOLOGY<br />
3. Describe <strong>the</strong> strengths and weaknesses <strong>of</strong> <strong>the</strong> teaching in your department.<br />
Strengths<br />
The teaching and scientific staff <strong>of</strong> department is well trained and motivated;<br />
most <strong>of</strong> <strong>the</strong>m have a medical degree. They are ready to accept new technologies<br />
and respond to <strong>the</strong> feedback given by students. The senior teaching staff<br />
has got a good experience in <strong>the</strong> experimental physiology, especially in <strong>the</strong><br />
field <strong>of</strong> respiratory and cardiovascular physiology, and in neuroscience. Several<br />
classical methods <strong>of</strong> physiology have been used during <strong>the</strong> practical<br />
classes: metabolic studies using <strong>the</strong> methods <strong>of</strong> Douglas-Haldane and Krogh,<br />
spirography, blood pressure measurement by Korotk<strong>of</strong>f. In addition, several<br />
original methods have been made available for <strong>the</strong> medical students, including<br />
<strong>the</strong> measurements <strong>of</strong> air flow by pneumotachograpy, alveolar ventilation and<br />
mean arterial blood pressure by differential oscillographic method. The using<br />
<strong>of</strong> computer-aided technology for studying <strong>of</strong> physiology <strong>of</strong> nerve and muscle<br />
tissue (action potential, muscular contraction etc.) by means <strong>of</strong> SimNerv interactive<br />
s<strong>of</strong>tware. The application <strong>of</strong> modern methods <strong>of</strong> molecular physiology<br />
for <strong>the</strong> study <strong>of</strong> gene polymorphisms in humans. The application <strong>of</strong> modern<br />
technology for <strong>the</strong> demonstration <strong>of</strong> animal experiments (CD, video recordings<br />
etc). Last but not least, <strong>the</strong> senior members <strong>of</strong> our department translated from<br />
<strong>the</strong> German language into <strong>the</strong> Estonian <strong>the</strong> textbook <strong>of</strong> Human physiology edited<br />
by R.F. Schmidt and G. Thews.<br />
Weaknesses<br />
We may still have too many lectures, although <strong>the</strong>ir number has been much<br />
reduced in favour <strong>of</strong> class work in small groups. For a proper conducting <strong>of</strong><br />
practical works <strong>the</strong> groups <strong>of</strong> students are too large. The selection <strong>of</strong> devices<br />
for practical works is small and <strong>the</strong> most <strong>of</strong> <strong>the</strong>m will urgently need <strong>the</strong> modernization.<br />
The students do not always have a chance to perform <strong>the</strong> experiments<br />
by <strong>the</strong>mselves. The limited amount <strong>of</strong> money allocated for teaching<br />
does not always allow to distribute <strong>the</strong> handouts among <strong>the</strong> students.<br />
4. Describe <strong>the</strong> innovations in your teaching.<br />
• In recent years we have started to use <strong>the</strong> computer-aided programs for illustrating<br />
<strong>of</strong> physiological processes (e.g. heart cycle) during <strong>the</strong> seminars<br />
and practical works. Also <strong>the</strong> computer programs are used as <strong>the</strong> practical<br />
tools by students for <strong>the</strong> studying <strong>of</strong> physiology <strong>of</strong> <strong>the</strong> nervous and muscle<br />
tissue (e.g. SimNerv, SimMuscle, and SimPatch).<br />
• Using <strong>of</strong> a web page (http:www.ut/ARFS/) for <strong>the</strong> presentation <strong>of</strong> teaching<br />
materials.<br />
• In order to reduce <strong>the</strong> number <strong>of</strong> lectures, we have introduced 6 seminars<br />
for small group to discuss complicated and integrated issues in physiology<br />
(principles <strong>of</strong> regulation in <strong>the</strong> level <strong>of</strong> cell and whole body, control <strong>of</strong> body<br />
temperature, autonomic nervous system, control <strong>of</strong> acid-base balance and<br />
osmotic pressure).<br />
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SECTION I: SELF-EVALUATION<br />
74<br />
• After many years we have re-established a course <strong>of</strong> Biophysics for <strong>the</strong><br />
medical students.<br />
• There is a good set <strong>of</strong> optional courses helping students to get <strong>the</strong> most recent<br />
scientific information in <strong>the</strong> certain fields <strong>of</strong> physiology (Neurophysiology<br />
<strong>of</strong> pain, Basic neuroscience, Research methods in respiratory physiology).<br />
• <strong>Department</strong> <strong>of</strong> Physiology has good facilities for demonstration <strong>of</strong> video<br />
tapes. Currently we are using <strong>the</strong> video recordings for <strong>the</strong> teaching <strong>of</strong> behavioural<br />
physiology. The students have a chance to score <strong>the</strong> animal behaviour<br />
from <strong>the</strong> video recordings.<br />
• We have taken an advantage from <strong>the</strong> developments <strong>of</strong> molecular physiology.<br />
We have introduced <strong>the</strong> method <strong>of</strong> a study <strong>of</strong> ACE gene polymorphism<br />
to <strong>the</strong> set <strong>of</strong> practical works delivered to <strong>the</strong> medical students.<br />
• We have a re-arranged <strong>the</strong> course schedules <strong>of</strong> Human physiology in order<br />
to increase <strong>the</strong> activity <strong>of</strong> students during <strong>the</strong> classes by taking out <strong>the</strong><br />
scores <strong>of</strong> tests, seminars and final exam in <strong>the</strong> forming <strong>of</strong> final grade for <strong>the</strong><br />
course.<br />
5. <strong>Name</strong> <strong>the</strong> factors which most disturb teaching (excluding financial resources).<br />
1. The co-ordination <strong>of</strong> curriculum between <strong>the</strong> pre-clinical departments is<br />
very limited.<br />
2. We have translated <strong>the</strong> textbook <strong>of</strong> R.F. Schmidt and G. Thews “Human<br />
physiology” into <strong>the</strong> Estonian language, but university library is lacking <strong>the</strong><br />
textbooks in <strong>the</strong> English (Guyton & Hall, Silverthorn etc). It is almost impossible<br />
to suggest <strong>the</strong> additional books, because <strong>the</strong>re may be only 1-2<br />
copies <strong>of</strong> that in <strong>the</strong> library.<br />
3. The teaching load <strong>of</strong> teachers per week is high.<br />
4. The groups <strong>of</strong> students are too big (sometimes more than 24 students) for<br />
our laboratory space.<br />
5. The background <strong>of</strong> students is very different if we are considering <strong>the</strong>ir basic<br />
level <strong>of</strong> knowledge. Several <strong>of</strong> <strong>the</strong>m are very poor in high school<br />
ma<strong>the</strong>matics and chemistry.<br />
II. EVALUATION OF TEACHING<br />
6. How is <strong>the</strong> quality <strong>of</strong> <strong>the</strong> teaching in your department evaluated? How are<br />
<strong>the</strong> content and <strong>the</strong> modes <strong>of</strong> <strong>the</strong> teaching changed on <strong>the</strong> basis <strong>of</strong> <strong>the</strong><br />
evaluation?<br />
There is no permanent system for <strong>the</strong> quality control in <strong>the</strong> Medical Faculty.<br />
However, during <strong>the</strong> last years <strong>the</strong> Dean’s Office <strong>of</strong> Medical Faculty in collaboration<br />
with <strong>the</strong> student organisations has started to evaluate <strong>the</strong> quality <strong>of</strong><br />
teaching, including also <strong>the</strong> <strong>Department</strong> <strong>of</strong> Physiology. For that purpose after<br />
<strong>the</strong> exam <strong>the</strong> anonymous questionnaires have been distributed among <strong>the</strong>
PHYSIOLOGY<br />
students. According to <strong>the</strong>se questionnaires several changes have been<br />
made. For example, <strong>the</strong> former oral examination <strong>of</strong> students was replaced by<br />
<strong>the</strong> written exam. The number <strong>of</strong> animal experiments was reduced to <strong>the</strong><br />
minimum. As a matter <strong>of</strong> fact, <strong>the</strong> students do not perform any animal experiment<br />
by <strong>the</strong>mselves. Instead <strong>of</strong> that <strong>the</strong> computer-aided simulations <strong>of</strong> <strong>the</strong><br />
animal experiments have been applied. Also <strong>the</strong> quality <strong>of</strong> lecture illustrations<br />
has been increased significantly.<br />
III. PEDAGOGIC TRAINING OF STAFF<br />
7. How many <strong>of</strong> <strong>the</strong> teachers have received pedagogic training?<br />
A few teachers have attended formal courses <strong>of</strong> pedagogic training. Occasional<br />
lectures or demonstrations have been attended by a majority <strong>of</strong> <strong>the</strong><br />
staff.<br />
8. Is <strong>the</strong>re a need for fur<strong>the</strong>r pedagogic training?<br />
We believe that <strong>the</strong> teaching skills <strong>of</strong> our senior members are reasonably good<br />
and obligatory courses may not improve <strong>the</strong>m significantly. However, we see<br />
<strong>the</strong> need for <strong>the</strong> pedagogic training <strong>of</strong> younger members and Ph.D. students.<br />
This can be performed in <strong>the</strong> University <strong>of</strong> Tartu.<br />
IV. TEACHING RESOURCES<br />
9. Is <strong>the</strong>re a need for rearrangement <strong>of</strong> <strong>the</strong> teaching resources in your department?<br />
If so, how should this be done?<br />
The working load <strong>of</strong> our teaching staff is above <strong>the</strong> <strong>of</strong>ficial limits and, <strong>the</strong>refore,<br />
<strong>the</strong> additional position <strong>of</strong> assistant is highly needed. The fur<strong>the</strong>r specialisation<br />
<strong>of</strong> our teachers to physiology, biophysics and neuroscience will be a matter <strong>of</strong><br />
near future. Forming <strong>of</strong> <strong>the</strong> chair <strong>of</strong> Biophysics at <strong>the</strong> <strong>Department</strong> <strong>of</strong> Physiology<br />
has been long time under <strong>the</strong> discussion, but not realised due to <strong>the</strong> lack<br />
<strong>of</strong> money.<br />
V. COORDINATION OF THE TEACHING<br />
10. How is <strong>the</strong> teaching co-ordinated with o<strong>the</strong>r departments? Indicate <strong>the</strong> departments<br />
that are closest to your department.<br />
The closest relations we have with <strong>the</strong> <strong>Department</strong> <strong>of</strong> Biochemistry in <strong>the</strong><br />
Medical Faculty, <strong>of</strong>ten we discuss <strong>the</strong> teaching matters with <strong>the</strong> members <strong>of</strong><br />
this department and we also co-ordinate <strong>the</strong> teaching with <strong>the</strong>m. Also we coordinate<br />
our teaching activities with <strong>the</strong> Faculty <strong>of</strong> Physics and Chemistry,<br />
Faculty <strong>of</strong> Social Sciences and Faculty <strong>of</strong> Philosophy since we are teaching<br />
Human Physiology and Neuroscience to <strong>the</strong> students <strong>of</strong> <strong>the</strong>se faculties.<br />
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SECTION I: SELF-EVALUATION<br />
VI. FUTURE PLANS<br />
11. Future plans to improve <strong>the</strong> teaching given by <strong>the</strong> department.<br />
1. As <strong>the</strong>re is a pr<strong>of</strong>ound change <strong>of</strong> paradigm in <strong>the</strong> life sciences into <strong>the</strong> direction<br />
<strong>of</strong> molecular level <strong>of</strong> organisation, we will keep our courses under<br />
permanent readiness to provide <strong>the</strong> latest <strong>the</strong>oretical knowledge and practical<br />
skills to our students. The integrative approach in physiology is clearly<br />
kept in mind.<br />
2. We are planning much wider use <strong>of</strong> interactive tools in teaching.<br />
3. The substantial improvement <strong>of</strong> teaching lab equipment is necessary. We<br />
are planning to obtain <strong>the</strong> modern teaching systems for physiology (e.g.<br />
PowerLab or Biopac Student Lab).<br />
4. We are aiming to include into <strong>the</strong> physiology course <strong>the</strong> classes where <strong>the</strong><br />
students will work with <strong>the</strong> new scientific information (publications and databases).<br />
5. We are planning to decrease <strong>the</strong> number <strong>of</strong> lectures. Instead <strong>of</strong> that we are<br />
planning <strong>the</strong> introduction <strong>of</strong> new seminars (in sensory physiology) and<br />
practical works applying <strong>the</strong> methods <strong>of</strong> molecular physiology.<br />
6. Development <strong>of</strong> a quality control system in <strong>the</strong> department is obligatory.<br />
7. Publication <strong>of</strong> new teaching materials in Estonian using for that purpose<br />
our web page resources.<br />
8. There is an obvious need to improve <strong>the</strong> collaboration between <strong>the</strong> preclinical<br />
departments for harmonising <strong>of</strong> existing courses and syllabi.<br />
76<br />
9. Toge<strong>the</strong>r with <strong>the</strong> development <strong>of</strong> basic courses <strong>the</strong>re is an obvious need<br />
to increase <strong>the</strong> quality <strong>of</strong> Ph.D. studies. For that purpose <strong>the</strong> Ph.D. School<br />
in Neuroscience and in Medical Sciences has to be created.
PHYSIOLOGY<br />
Physiology: resource evaluation<br />
1. Study materials<br />
- How many study books are published in your institution during last five years? 3<br />
- Do you have separate room as library in your place? Yes No<br />
- Could students borrow study books from your institution? Yes No<br />
- Do you have on-line published study materials for students? Yes No<br />
- WWW address: www.ut.ee/arfs/<br />
- Does University library has enough modern books in your speciality?<br />
Completely enough Enough Scarcely Absolutely scarcely No<br />
2. Amount and size <strong>of</strong> study rooms<br />
- Rooms used by Your institution only: 2 rooms with area <strong>of</strong> 134 m 2<br />
- Rooms shared with ano<strong>the</strong>r institution: 7 rooms with area <strong>of</strong> ~500 m 2<br />
- Do You have enough space for study process by Your opinion?<br />
Completely enough Enough Scarce Absolutely scarcely<br />
- How <strong>the</strong> scarce <strong>of</strong> space should be handled or changed?<br />
New building Change to smaller student groups Better logistics<br />
O<strong>the</strong>r way (describe shortly)<br />
3. Current situation <strong>of</strong> study rooms<br />
- There has been repairments in last years (except Biomedicum)<br />
- How are <strong>the</strong> study rooms lightened?<br />
Very good Good Some darkness Absolutely dark for study<br />
- Evaluation <strong>of</strong> general conditions: Very good Good Satisfactory Bad<br />
4. Your institution has<br />
a) 1 (how many?) auditorium(s) for workshops/seminars with 24 places, equipped with<br />
Blackboard<br />
White board & markers<br />
Screen<br />
Overhead projector<br />
Data projector<br />
Slide projector<br />
b) 1 (how many?) laboratories for practicals with 24 places, equipped with<br />
Blackboard<br />
White board and markers<br />
Screen<br />
Overhead projector<br />
Data projector<br />
Slide projection kit<br />
TV/Video projection set<br />
Computer<br />
Internet connection<br />
TV/Video projection kit<br />
Computer<br />
Internet connection<br />
5. Working rooms for teaching staff and postgraduate students:<br />
- Number <strong>of</strong> teaching staff 8<br />
- Number <strong>of</strong> rooms for staff 4<br />
- Number <strong>of</strong> individual working places 8, among <strong>the</strong>m with computers 8<br />
- Number <strong>of</strong> postgraduate students is 3<br />
- How many individual working places <strong>the</strong>y have? 3<br />
- How many computers <strong>the</strong>y have? 3<br />
6. O<strong>the</strong>r comments on resource topic (max 250 letters): Due to <strong>the</strong> moving <strong>of</strong> <strong>the</strong><br />
<strong>Department</strong> to <strong>the</strong> Biomedicum <strong>the</strong> teaching resources have been improved significantly.<br />
However, we are still lacking enough space for <strong>the</strong> performing <strong>of</strong> work in small groups,<br />
and <strong>the</strong>re is no places for independent work.<br />
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SECTION I: APPENDIXES<br />
APPENDIX I-I<br />
Visits <strong>of</strong> <strong>the</strong> <strong>Department</strong> members to o<strong>the</strong>r institutions abroad during 1996-2000<br />
Year Researcher/Lectures Institution Country Purpose Duration<br />
1996 Aavo Lang/Docent Nottingham University UK Research 8 weeks<br />
1996 Aavo Lang/Docent Strassbourg France Conference 5 days<br />
1996 Eero Vasar, pr<strong>of</strong>essor Melbourne Australia Conference 1 week<br />
1996 Eero Vasar, pr<strong>of</strong>essor Toronto Canada Conference 1 week<br />
1996 Kersti Jagomägi, sen researcher Munich Germany Research 1 week<br />
1996 Kersti Jagomägi, sen researcher University <strong>of</strong> Oslo Norway Research 3 weeks<br />
1996 Rein Raamat, sen researcher Tampere University <strong>of</strong><br />
Technology<br />
Finland Research 2 weeks<br />
1996 Rein Raamat, sen researcher University <strong>of</strong> Oslo Norway Research 4 weeks<br />
1996 Selma Teesalu, pr<strong>of</strong>essor<br />
emeritus<br />
Lillehammer Norway Conference 1 week<br />
1996 Sulev Kõks/Research Fellow Kuopio University Finland Research 2 months<br />
1996 Sulev Kõks/Research Fellow Kuopio University Finland Course 1 week<br />
1996 Vallo Volke/Researcher Kuopio University Finland Research 2 months<br />
1997 Aavo Lang/Docent Vilnius Lithuania Conference 2 days<br />
1997 Andres Soosaar/Docent Casamicciola/Napoli Italy Conference 1 week<br />
1997 Eero Vasar, pr<strong>of</strong>essor Riga Latvia Conference 1 week<br />
1997 Eero Vasar, pr<strong>of</strong>essor University <strong>of</strong> Helsinki Finland Lecture 1 week<br />
1997 Eero Vasar, pr<strong>of</strong>essor Nice France Conference 1 week<br />
1997 Eero Vasar, pr<strong>of</strong>essor University <strong>of</strong> Cambridge UK Conference 1 week<br />
1997 Kersti Jagomägi, sen researcher IFMBE, Nice France Research 1 week<br />
1997 Peet-Henn Kingisepp, docent Hanasaari Finland Conference 4 days<br />
1997 Rein Raamat, sen researcher IFMBE, Nice France Research 1 week<br />
1997 Selma Teesalu, pr<strong>of</strong>essor<br />
emeritus<br />
Montreal Canada Conference 1 week<br />
1998 Aavo Lang/Docent Bonn Germany Conference 5 days<br />
1998 Andres Soosaar/Docent Linkoping University Sweden Training 2 weeks<br />
1998 Andres Soosaar/Docent King's College London UK Training 2 weeks<br />
1998 Eero Vasar, pr<strong>of</strong>essor Hamburg Germany Conference 1 week<br />
1998 Eero Vasar, pr<strong>of</strong>essor Brno Czech Rep. Conference 1 week<br />
1998 Jana Kivastik, assistant University <strong>of</strong> Oxford UK Training 4 weeks<br />
1998 Jana Kivastik, assistant Hamburg Germany Conference 1 week<br />
1998 Kersti Jagomägi, sen researcher Kuopio University Hospital Finland Research 3 weeks<br />
1998 Kersti Jagomägi, sen researcher University <strong>of</strong> Latvia Latvia Research 1 week<br />
1998 Peet-Henn Kingisepp, docent Riga Technical University Latvia Meeting 4 days<br />
1998 Peet-Henn Kingisepp, docent King's College London UK Training 2 weeks<br />
1998 Rein Raamat, sen researcher Linköping University Sweden Teaching 2 weeks<br />
1998 Rein Raamat, sen researcher Kuopio University Hospital Finland Research 3 weeks<br />
1998 Selma Teesalu, pr<strong>of</strong>essor<br />
emeritus<br />
Bornholm Denmark Conference 1 week<br />
1998 Sulev Kõks/Research Fellow Hamburg Germany Conference 1 week<br />
1998 Sulev Kõks/Research Fellow Brno Czech Rep. Conference 1 week<br />
1998 Vallo Volke/Researcher Aarhus University Denmark Research 6 months<br />
1999 Aavo Lang/Docent Marienhamn Finland Conference 4 days<br />
1999 Andres Soosaar/Docent King's College London UK Training 2 weeks<br />
1999 Eero Vasar, pr<strong>of</strong>essor University <strong>of</strong> Zürich Switzerland Lecture 1 week<br />
1999 Eero Vasar, pr<strong>of</strong>essor King's College London UK Training 1 week<br />
1999 Eero Vasar, pr<strong>of</strong>essor Prague Czech Rep. Conference 1 week<br />
1999 Eero Vasar, pr<strong>of</strong>essor Helsinki Finland Conference 1 week<br />
1999 Jana Kivastik, assistant Prague Czech Rep. Conference 1 week<br />
1999 Kersti Jagomägi, sen researcher Linköping University Sweden Research 2 weeks<br />
78
PHYSIOLOGY<br />
1999 Kersti Jagomägi, sen researcher Kuopio University Hospital Finland Research 3 weeks<br />
1999 Peet-Henn Kingisepp, docent Prague Czech Rep. Conference 1 week<br />
1999 Peet-Henn Kingisepp, docent Riga Technical University Latvia Meeting 4 days<br />
1999 Peet-Henn Kingisepp, docent King's College London UK Training 2 weeks<br />
1999 Peet-Henn Kingisepp, docent University <strong>of</strong> Linköping Sweden Training 1 week<br />
1999 Rein Raamat, sen researcher Linköping University Sweden Research 2 weeks<br />
1999 Rein Raamat, sen researcher Kuopio University Hospital Finland Research 3 weeks<br />
1999 Rein Raamat, sen researcher Kings College London UK Teaching 2 weeks<br />
1999 Selma Teesalu, pr<strong>of</strong>essor<br />
emeritus<br />
Ronneby Sweden conference 1 week<br />
1999 Sulev Kõks/Research Fellow Edinburgh UK EMBL Course 2 weeks<br />
1999 Sulev Kõks/Research Fellow Prague Czech Rep. Conference 1 week<br />
1999 Sulev Kõks/Research Fellow Helsinki Finland Conference 1 week<br />
1999 Vallo Volke/Researcher NO society conference USA Conference 5 days<br />
2000 Aavo Lang/Docent Uppsala Sweden Meeting 2 days<br />
2000 Aavo Lang/Docent Helsinki Finland Conference 2 days<br />
2000 Aavo Lang/Docent Stockholm Sweden Conference 4 days<br />
2000 Aavo Lang/Docent Versailles France Conference 5 days<br />
2000 Aavo Lang/Docent Copenhagen Denmark Meeting 2 days<br />
2000 Andres Soosaar/Docent Indiana University USA Research 8 months<br />
2000 Eero Vasar, pr<strong>of</strong>essor University <strong>of</strong> Oxford England Conference 1 week<br />
2000 Eero Vasar, pr<strong>of</strong>essor St. Petersburg Russia Conference 1 week<br />
2000 Eero Vasar, pr<strong>of</strong>essor European Union, Brussels Belgium Meeting 1 week<br />
2000 Eero Vasar, pr<strong>of</strong>essor University <strong>of</strong> Hamburg Germany Meeting 1 week<br />
2000 Jana Kivastik, assistant Florence Italy Conference 1 week<br />
2000 Peet-Henn Kingisepp, docent Kaunas University <strong>of</strong> Technology<br />
Lithuania Meeting 4 days<br />
2000 Rein Raamat, sen researcher University <strong>of</strong> Illinois USA Research 1 week<br />
2000 Rein Raamat, sen researcher Kaunas University <strong>of</strong> Technology<br />
Lithuania Teaching 1 week<br />
2000 Selma Teesalu, pr<strong>of</strong>essor<br />
emeritus<br />
Aland Sweden Conference 1 week<br />
2000 Selma Teesalu, pr<strong>of</strong>essor<br />
emeritus<br />
Tampere Finland Conference 1 week<br />
2000 Sulev Kõks/ Research Fellow St. Petersburg Russia Conference 1 week<br />
2000 Vallo Volke/Researcher Aarhus University Denmark Research 1 week<br />
APPENDIX I-II<br />
Postgraduate students at <strong>the</strong> <strong>Department</strong> having studied abroad during 1996-2000<br />
Year <strong>Name</strong> Institution Contry Duration<br />
1996 Sulev Kõks University <strong>of</strong> Kuopio Finland 2 months<br />
1996 Vallo Volke University <strong>of</strong> Kuopio Finland 2 months<br />
1999 Sulev Kõks University <strong>of</strong> Edinburgh U.K. 2 weeks<br />
1998 Vallo Volke University <strong>of</strong> Arhus Denmark 6 months<br />
1998 Jana Kivastik University <strong>of</strong> Oxford UK 4 weeks<br />
79
SECTION I: APPENDIXES<br />
APPENDIX I-III<br />
Co-operation with institutions from o<strong>the</strong>r countries and participation in international<br />
research projects during 1996-2000<br />
Contact person Institution Country Aim<br />
P.-H.Kingisepp University <strong>of</strong> Oulu Finland Research<br />
Kersti Jagomägi University <strong>of</strong> Kuopio Finland Research<br />
Rein Raamat University <strong>of</strong> Linköping Sweden Research<br />
Kersti Jagomägi University <strong>of</strong> Oslo Norway Research<br />
Rein Raamat Kings College London UK Teaching<br />
Jaak Talts TNO Amsterdam Ne<strong>the</strong>rlands Research<br />
Jana Kivastik University <strong>of</strong> Birmingham UK Research<br />
Eero Vasar University <strong>of</strong> Nantes France Research<br />
Eero Vasar University <strong>of</strong> Kuopio Finland Research<br />
Eero Vasar University <strong>of</strong> Ottawa Canada Research<br />
APPENDIX I-IV<br />
Visiting lecturers at <strong>the</strong> <strong>Department</strong> during 1996-2000<br />
Visitor Institution Country Purpose <strong>of</strong> <strong>the</strong> Visit<br />
Pr<strong>of</strong>. Alfred Strickholm University <strong>of</strong> Indiana USA Teaching<br />
Pr<strong>of</strong>. Heikki Rauvala University <strong>of</strong> Helsinki Finland Research, teaching<br />
Pr<strong>of</strong>. Michel Bourin University <strong>of</strong> Nantes France Research, teaching<br />
Dr. Colin J. Greengrass University <strong>of</strong> Singapore Singapore Research, teaching<br />
Pr<strong>of</strong>. Juhani Leppäluoto University <strong>of</strong> Oulu Finland Teaching<br />
Pr<strong>of</strong>. Johannes Piiper University <strong>of</strong> Göttingen Germany Teaching<br />
Dr. Rauno Heikkinen University <strong>of</strong> Oulu Finland Teaching<br />
Pr<strong>of</strong>. A.Öberg University <strong>of</strong> Linköping Sweden Research<br />
Dr. B.Larsby University <strong>of</strong> Linköping Sweden Research<br />
I.Välimäki University <strong>of</strong> Turku Finland Research<br />
M.Wheatley Birmingham University UK Research<br />
Dr. Anssi Sovijärvi University <strong>of</strong> Helsinki Finland Research<br />
Pr<strong>of</strong>. Esko Länsimies University <strong>of</strong> Kuopio Finland Research<br />
Pr<strong>of</strong>. Rainer Rauramaa University <strong>of</strong> Kuopio Finland Research<br />
Pr<strong>of</strong>. Pekka T. Männistö University <strong>of</strong> KUopio Finland Research<br />
APPENDIX I-V<br />
Scientific journals available at <strong>the</strong> <strong>Department</strong><br />
No <strong>Name</strong> <strong>of</strong> Journal Version<br />
1. European Journal <strong>of</strong> Neuroscience online<br />
2. European Neuropsychopharmacology paper<br />
3. European Respiratory Journal paper, online, CD<br />
4. Nature Medicine paper, online<br />
5. Nature Neuroscience paper, online<br />
6. Neuron online<br />
7. News in Physiological Sciences paper, online<br />
8. Science paper, online<br />
9. Trends in Neurosciences paper, online<br />
10. Trends in Pharmacological Sciences paper, online<br />
80
APPENDIX I-VI<br />
Publications <strong>of</strong> <strong>the</strong> <strong>Department</strong> members during 1996-2000<br />
MONOGRAPHS<br />
PHYSIOLOGY<br />
1. <br />
2. 1-70.<br />
3. V. Volke Pharmacological and biochemical studies on nitric oxide in <strong>the</strong> regulation <strong>of</strong> behaviour.<br />
Tartu, 1999, 1-56 (doctoral dissertation).<br />
4. S. Kõks Cholecystokinin (CCK)-induced anxiety in rats: influence <strong>of</strong> environmental stimuli and involvement<br />
<strong>of</strong> endopioid mechanisms and serotonin. Tartu, 1999, 1-60 (doctoral dissertation).<br />
5. J.Kivastik. “Lung function in Estonian schoolchildren: relationship with anthropometric indices and<br />
respiratory symptoms, reference values for dynamic spirometry”, Tartu 2000, pp. 1-122 (doctoral<br />
dissertation)<br />
PAPERS IN INTERNATIONAL JOURNALS<br />
1. Jagomägi K., Talts J., Raamat R., Länsimies E. Continuous non-invasive measurement <strong>of</strong> mean<br />
blood pressure in fingers by volume-clamp and differential oscillometric method. Clinical Physiology,<br />
1996, 16, 551-560<br />
2. Jagomägi K., Raamat R., Pulges A. The effect <strong>of</strong> cervicothoracic sympa<strong>the</strong>ctomy on finger skin<br />
blood flow in patients with Raynaud s phenomenon. Sixth World Congress for Microcirculation Bologna,<br />
Italy, Monduzzi Editore, Int. Proc. Div, 1996, 961-964<br />
3. P.-H.Kingisepp, V.Pert, P.Loog, J.Talts, R.Raamat Estimation <strong>of</strong> mixed venous carbon dioxide<br />
pressure by a single breath method using various computing techniques. Acta Medica Baltica,<br />
1996, 3, 198-202<br />
4. Aarnisalo A.M., Vainio P.J., Männistö P.T., Vasar E., Tuominen R.K. Evidence for cholecystokininA<br />
receptors in bovine adrenal chromaffin cells. NeuroReport, 1996, 7, 2167-2170.<br />
5. Volke V., Soosaar A., Kõks S., Bourin M., Männistö P.T. Nitric oxide mediates caerulein-induced<br />
suppression <strong>of</strong> locomotor activity. Neuropeptides, 1996, 4, 323-326.<br />
6. Bourin M., Malinge M., Vasar E., Bradwejn J. Two faces <strong>of</strong> cholecystokinin: anxiety and schizophrenia.<br />
Fundam Clin Pharmacol, 1996, 10, 116-126.<br />
7. Gacsalyi I., Gigler G., Szabados T., Kovacs A., Vasar E., Lang A., Männistö P.T. Different antagonistic<br />
activity <strong>of</strong> deranciclane (EGIS-3886) on peripheral and central 5-HT2 receptors. Pharm<br />
Pharmacol Lett., 1996, 6, 82-85.<br />
8. Volke V, Soosaar A, Kõks S, Bourin M, Männistö PT, Vasar E (1997) 7-nitroindazole, a nitric oxide<br />
synthase inhibitor, has anxiolytic-like properties in exploratory models <strong>of</strong> anxiety. Psychopharmacology<br />
131: 399-405.<br />
9. A.Aluoja, J.Shlik, V.Vasar, P.-H.Kingisepp, K.Jagomägi, E.Vasar, J.Bradwejn. Emotional and cognitive<br />
factors connected with response to cholecystokinin tetrapeptide in healthy volunteers. - Psychiatry<br />
Res, 1997, 66, 59-67.<br />
10. J. Kivastik, P.-H. Kingisepp Differences in ling function and chest dimensions in school-age girls<br />
and boys. Clinical Physiology, 1997, 17, 149-157.<br />
11. P.Plakk, P.Liik, P.-H.Kingisepp. Hot wire anemometer for spirography. – Med. Biol. Eng. Comp.,<br />
1997, 35, 1-5<br />
12. S. Kõks, E. Vasar, A. Soosaar, A. Lang, V. Volke, V. Võikar, M. Bourin, P.T. Männistö Relation <strong>of</strong><br />
exploratory behavior in elevated plus-maze to brain receptor binding properties and serum growth<br />
hormone levels. European Neuropsychopharmacology, 1997, 7, 289-294<br />
13. Gacsalyi I., E. Schmidt, I. Gyertyan, E. Vasar, A. Lang, A. Haapalinna, M. Fekete, J. Hietala, E.<br />
Syvälahti, P. Tuomainen, P.T. Männistö Receptor Binding Pr<strong>of</strong>ile and Anxiolytic-Type Activity <strong>of</strong><br />
Deramciclane (EGIS-3886) in Animal Models. Drug Development Research, 1997, 40, 333-348.<br />
14. Shlik J., Vasar V., Aluoja A., Kingisepp P.-H., Jagomägi K., Vasar E., Rägo L., Bradwejn J. The<br />
effect <strong>of</strong> cholecystokinin tetrapeptide on respiratory resistance in healthy volunteers. - Biol Psychiatry,<br />
1997, 42, 206-212.<br />
15. J. Shlik, A. Aluoja, V. Vasar, E. Vasar, T. Podar, J. Bradwejn Effect <strong>of</strong> citalopram treatment on behavioural,<br />
cardiovascular and neuroendocrine response to cholecystokinin tetrapeptide challenge<br />
in patients with panic disorder, J Psychiatry Neurosci 1997, 22, 332-340.<br />
16. J. Shlik, E. Vasar, J. Bradwejn Cholecystokinin antagonists: potential role in <strong>the</strong> treatment <strong>of</strong><br />
neuropsychiatric disorders. CNS Drugs, 1997, 8, 134-152.<br />
81
SECTION I: APPENDIXES<br />
17. S. Kõks, A. Soosaar, V. Võikar, V. Volke, M. Ustav, P.T. Männistö, M. Bourin, E. Vasar. Opioid<br />
antagonist naloxone potentiates anxiogenic-like action <strong>of</strong> cholecystokinin agonists in elevated plusmaze.<br />
Neuropeptides, 1998, 32(3); 235-240.<br />
18. J. Kivastik Review: Paediatric reference values for spirometry. Clin Physiology, 1998 (6), 489-497.<br />
19. Volke V, Soosaar A. Kõks S, Vasar E, Männistö PT (1998) L-arginine abolishes <strong>the</strong> anxiolytic-like<br />
effect <strong>of</strong> diazepam in <strong>the</strong> elevated plus-maze test in rats. European Journal <strong>of</strong> Pharmacology 351:<br />
287-290.<br />
20. P.Plakk, P. Liik, P.-H. Kingisepp Hot-wire anemometer for spirography. Med.Biol.Eng.Comput.,<br />
1998, 36, 17-21.<br />
21. R.Raamat, J.Talts, K.Jagomägi, E.Länsimies Ma<strong>the</strong>matical modelling <strong>of</strong> non-invasive oscillometric<br />
finger mean blood pressure measurement by maximum oscillation criterion Med. Biol. Eng. Comp,<br />
1999, 37, 784-788.<br />
22. M. Bourin, M. Malinge, M.C. Colombel, E. Vasar Cholecystokinin receptor agonists block <strong>the</strong><br />
jumping behaviour precipitated in morphine-dependent mice by naloxone. European Neuropsychopharmacology,<br />
1999, 9, 37-43<br />
23. V. Volke, G. Wegener, E. Vasar, R. Rosenberg Methylene blue inhibits hippocampal nitric oxide<br />
synthase activity in vivo. Brain Research, 1999, 826, 303-305.<br />
24. S. Kõks, A. Soosaar, V. Võikar, M. Bourin, E. Vasar BOC-CCK-4, CCKB receptor agonist, antagonizes<br />
anxiolytic-like action <strong>of</strong> morphine in elevated plus-maze. Neuropeptides, 1999, 33, 63-69.<br />
25. S. Kõks, M. Bourin, V. Võikar, A. Soosaar, E. Vasar Role <strong>of</strong> CCK in anti-exploratory action <strong>of</strong> paroxetine,<br />
5-HT reuptake inhibitor. International Journal <strong>of</strong> Neuropsychopharmacology, 1999, 2, 9-16.<br />
26. V. Võikar, A. Sooaar, V. Volke, S. Kõks, M. Bourin, P.T. Männistö, E. Vasar Apomorphine-induced<br />
behavioural sensitization in rats: individual differences, role <strong>of</strong> dopamine and NMDA receptors.<br />
European Neuropsychopharmacology, 1999, 9, 507-514.<br />
27. Soosaar The morph<strong>of</strong>unctional strategies to find neural correlates <strong>of</strong> consciousness. In: Neuronal<br />
Bases and Psychological Aspects <strong>of</strong> Consciousness. London, World Scientific Press, 1999, 541-<br />
545.<br />
28. Wegener G, Volke V, Rosenberg R. (2000) Endogenous nitric oxide decreases hippocampal levels<br />
<strong>of</strong> serotonin and dopamine in vivo. British Journal <strong>of</strong> Pharmacology 130: 575-80.<br />
29. R.Raamat, K.Jagomägi, J.Talts, P.-H.Kingisepp. Effect <strong>of</strong> Peripheral Vasoconstriction on <strong>the</strong> Beatto-Beat<br />
Measurement <strong>of</strong> Finger Blood Pressure. World Congress on Medical Physics and Biomedical<br />
Engineering, Chicago, 22-28. July 2000. 4 pages on CD.<br />
30. R.Raamat, K.Jagomägi, J.Talts. Different Responses <strong>of</strong> Finapres and <strong>the</strong> Oscillometric Finger<br />
Blood Pressure Monitor During Intensive Vasomotion. Journal <strong>of</strong> Medical Engineering & Technology,<br />
2000, 24, 3, 95-101.<br />
31. A.Nurmekivi, P.-H.Kingisepp. Capacity <strong>of</strong> <strong>the</strong> respiratory system and <strong>the</strong> potential to influence it.<br />
Modern athlete and coach, 2000, 38, 8-12.<br />
32. S. Kõks, P.T. Männistö, M. Bourin, J. Shlik, V. Vasar, E. Vasar Cholecystokinin (CCK) in <strong>the</strong> rat<br />
plus-maze model <strong>of</strong> anxiety B a possible relation to human disorders. Journal <strong>of</strong> Psychiatry & Neuroscience,<br />
2000, 25, 33-42.<br />
33. A. Veraksits, I. Bileviciute-Ljungar, J. Maaroos, E. Vasar, T. Lundeberg Neuronal mechanisms<br />
contribute to corticotropin-releasing factor-induced anti-oedema effect in <strong>the</strong> rat hind paw. Neuropeptides,<br />
2000, 34, 129-134.<br />
34. Wegener G, Volke V, Bandpey Z, Rosenberg R. (2001) Nitric oxide modulates lithium-induced conditioned<br />
taste aversion. Behavioral Brain Research 118: 195-200.<br />
PAPERS IN ESTONIAN JOURNALS<br />
1. Jagomägi K., Viigimaa M., Hendrikson E., Talts J., Raamat R., Teesalu R. Arteriaalse vererõhu ja<br />
südame löögisageduse variaabelsuse määramine funktsionaalsete testide ajal. südamelihase infarkti<br />
ägedas faasis. Eesti Arst, 1996, 2, 105-108<br />
62. J. Kivastik, P.-H. Kingisepp Voolu-mahu lingu näitajate hajuvus laste kordusuuringutel. Eesti Arst,<br />
1996, 5, 410-412.<br />
63. P.-H. Kingisepp, J. Kivastik Lämmastiku üksihingamistesti rakendamisest kopsude funktsionaalse<br />
seisundi hindamisel. Eesti Arst, 1997, 5, 396-400.<br />
64. P.-H.Kingisepp, V.Pert Kopsude difusioonivõime määramine CO üksikhingamispeetuse meetodil<br />
Eesti Arst 1998, 6, 499-501.<br />
65. R.Raamat, J.Talts, K.Jagomägi. Theoretical study <strong>of</strong> discrepancies in estimation <strong>of</strong> mean blood<br />
pressure by Marey’s criterion. Proc. Estonian Acad. Sci. Eng., 1999, 5, 4, 281-292.<br />
66. P.-H.Kingisepp Georg Kingisepa meditsiiniõpingutest Heidelbergis. Eesti Arst, 1999, 2, 166-171.<br />
82
PHYSIOLOGY<br />
67. J.Kivastik, P.-H.Kingisepp Voolu-mahu lingu näitajad tervetel ja hingamiskaebustega lastel. Eesti<br />
Arst, 1999, 4, 291-294.<br />
SUBMITTED PAPERS<br />
1. K.Jagomägi, R.Raamat, J.Talts. Effect <strong>of</strong> Peripheral Vasomotion on <strong>the</strong> Measurement <strong>of</strong> Finger<br />
Blood Pressure. Blood Pressure Monitoring. 2001, 6, (Accepted).<br />
2. P.-H.Kingisepp, K.Jagomägi, R.Raamat. Changes <strong>of</strong> heart rate and blood pressure in registration<br />
<strong>of</strong> forced respiration flow-volume loop. Clinical Physiology, 2001, 21, (Accepted)<br />
3. R.Raamat, K.Jagomägi, J.Talts, E.Länsimies, J.Jurvelin, P.Kolari. Continuous mean arterial pressure<br />
measurement in <strong>the</strong> fingers: <strong>the</strong> influence <strong>of</strong> hand local cooling. Journal <strong>of</strong> Medical Engineering<br />
and Technology, 2001 (Accepted).<br />
4. R.Raamat, R.Lõhmus, A.Lõhmus, P.Liblik, M.Lobjakas, L.Montelius, J.Lindahl, D.Erts, H.Olin. Piezoresonance<br />
driver for positioning in scanning probe microscope in a wide temperature range. Ferroelectrics.<br />
Submitted.<br />
5. J.Kivastik, P.-H.Kingisepp Spirometric reference values in Estonian schoolchildren, Clinical Physiology,<br />
submitted.<br />
6. Kõks S, Beljajev S, Koovit I, Abramov U, Bourin M, Vasar E 8-OH-DPAT, but not deramciclane,<br />
antagonizes <strong>the</strong> anxiogenic-like action <strong>of</strong> paroxetine in elevated plus-maze. Psychopharmacology,<br />
2000 (online publication 14/12/2000).<br />
7. Võikar V, Kõks S, Vasar E, Rauvala H Strain and gender differences in <strong>the</strong> behavior <strong>of</strong> mouse lines<br />
commonly used in transgenic studies. Physiology & Behavior, 2001 (in press).<br />
8. S. Kõks, U. Abramov, T. Sillat, A. Veraksitš, M. Bourin 2 , T. Matsui 1 , E. Vasar CCK2 receptordeficient<br />
mice have increased sensitivity <strong>of</strong> dopamine D2 receptors. Neuropeptides, 2001 (submitted).<br />
TEXTBOOKS AND MANUALS<br />
1. J.Kivastik, P.-H.Kingisepp. “Lung function testing in children”, Tartu 1999, pp. 1–28 (in Estonian,<br />
guidelines for <strong>the</strong> assessment <strong>of</strong> flow-volume curves).<br />
2. R.F.Schmidt, G.Thews Inimese füsioloogia, Tartu 1997 (ISBN 9985-60-309-5) P.-H.Kingisepa tõlgitud<br />
peatükid 7., 8. (lk 176-206), 15. (lk 340-348), 21, 22, 23, 24 (lk 574-659) ja indeksi koostamine<br />
lk. 847-880<br />
3. P.-H.Kingisepp (toimetaja). Koostajad: K.Jagomägi, P.-H.Kingisepp, V.Pert, A.Soosaar, I.-O.Vaasa<br />
Füsioloogia praktikum I Tartu Ülikooli Kirjastus Tartu 1999, 125 lk.<br />
4. P.-H.Kingisepp Inimese füsioloogia Atlex Tartu 2000, 265 lk.<br />
83
APPENDIX I-VII<br />
Academic and administrative personnel: <strong>Department</strong> <strong>of</strong> Physiology<br />
PHYSIOLOGY<br />
<strong>Name</strong> Title Load Area Gender Birth year Scientific degree Year <strong>of</strong> commencement Labour time (y)<br />
1. Eero Vasar Pr<strong>of</strong>essor 1,00 Physiology Male 1954 Dr.Med 1992 17<br />
2. Selma Teesalu Pr<strong>of</strong>essor Emeritus Physiology Female 1930 Dr.Med 1975 47<br />
3. Peet-Henn Kingisepp Docent 1,00 Physiology Male 1936 Cand.Sci 1973 37<br />
4. Andres Soosaar Docent 1,00 Physiology Male 1961 Cand.Sci 1989 12<br />
5. Aavo Lang Docent 1,00 Physiology Male 1964 Dr.Med 1995 12<br />
6. Vello Pert Lecturer 1,00 Physiology Male 1940 Cand.Sci<br />
7. Ivar-Olavi Vaasa Lecturer 1,00 Physiology Male 1941 23<br />
8. Jana Kivastik Assistant 1,00 Physiology Female 1967 Dr.Med 2000 6<br />
9. Kertu Rünkorg Assistant 1,00 Physiology Female 1973 2<br />
10. Jüri Vedru Sr. Researcher 0,50 Biophysics Male 1948 Cand.Sci 1988 28<br />
11. Rein Raamat Sr. Researcher 1,00 Biophysics Male 1941 Cand.Sci 1977 23<br />
12. Kersti Jagomägi Sr. Researcher 1,00 Biophysics Female 1942 Cand.Sci 1975 33<br />
13. Sulev Kõks Researcher 1,00 Neuroscience Male 1971 Ph.D 1999 7<br />
14. Vallo Volke Researcher 1,00 Neuroscience Male 1971 Dr.Med 1999 7<br />
15. Ljudmilla Savihhina Sr. Engineer 1,00 Female 1948 25<br />
16. Hele-Mall Laumann Sr. Technical staff 1,00 Female 1931 13<br />
17. Nevel Mölder Secretary 1,00 Female 1975 1<br />
1 Cand.Sci is degree <strong>of</strong> <strong>the</strong> Former Soviet Union which corresponds to a Ph.D<br />
85
APPENDIX I-VIII<br />
Curriculum Vitae <strong>of</strong> <strong>the</strong> staff<br />
PHYSIOLOGY<br />
VASAR, EERO Date <strong>of</strong> birth: 17.09.1954Gender: maleCitizenship: EstoniaAddress: 27 Hurda Street,<br />
51005 Tartu, EstoniaEducational history: 1973-1979 - Student, Medical Faculty, University <strong>of</strong> Tartu<br />
1979-1983 - Ph.D. student, <strong>Department</strong>s <strong>of</strong> Pharmacology and Physiology, University <strong>of</strong> TartuAcademic<br />
degrees (with year and university): Doctor <strong>of</strong> Medical Sciences, 5/02/1992: "Role <strong>of</strong><br />
cholecystokinin receptors in <strong>the</strong> regulation <strong>of</strong> behaviour and in <strong>the</strong> action <strong>of</strong> haloperidol and<br />
diazepam", University <strong>of</strong> Tartu1992 - Pr<strong>of</strong>essor <strong>of</strong> Physiology, University <strong>of</strong> TartuEmployment and<br />
pr<strong>of</strong>essional experience: 1983-1991 - Head, Laboratory <strong>of</strong> Psychopharmacology, Institute <strong>of</strong> General<br />
and Molecular Pathology, University <strong>of</strong> Tartu.1991-up to now- Pr<strong>of</strong>essor and Head, <strong>Department</strong> <strong>of</strong><br />
Physiology, University <strong>of</strong> Tartu. Administrative experience: Vice Dean <strong>of</strong> Research and Development,<br />
Medical Faculty, University <strong>of</strong> Tartu, 2000Honours and awards:Membership in academic and<br />
scientific societies: 1991 - up to now - a president <strong>of</strong> <strong>the</strong> Estonian Physiological Society1991 - a<br />
member <strong>of</strong> <strong>the</strong> Estonian Pharmacological Society1992 - a member <strong>of</strong> <strong>the</strong> Estonian Society <strong>of</strong><br />
Biological Psychiatry1994 - a member <strong>of</strong> <strong>the</strong> European Behavioural Pharmacology Society1996 - a<br />
member <strong>of</strong> <strong>the</strong> Estonian Science Award Committee1996 – a council member <strong>of</strong> <strong>the</strong> Federation <strong>of</strong><br />
European Physiological Societies1997 - a member <strong>of</strong> <strong>the</strong> Estonian Science Competence Board1998 -<br />
a member <strong>of</strong> <strong>the</strong> European College <strong>of</strong> NeuropsychopharmacologyCurrent research program and<br />
grants: 1999-2002 - The research grant from <strong>the</strong> Estonian Science Foundation “Generation and<br />
characterization <strong>of</strong> brain-specific CCKB knockout mouse: new model for investigating <strong>the</strong> role <strong>of</strong><br />
cholecystokinin in <strong>the</strong> central nervous system”. 1999-2001 - James S. McDonnel Foundation Grant<br />
(U.S.A.) “Neuropeptide receptor signal transduction as a target for drug development for <strong>the</strong> treatment<br />
<strong>of</strong> cognitive disorders”Supervision <strong>of</strong> dissertations: Andres Soosaar, Ph.D. degree in 1989Jaanus<br />
Harro, Ph.D. degree in 1990Aavo Lang, Ph.D. degree in 1995Sulev Kõks - Ph.D.degree in 1999Vallo<br />
Volke - Ph.D. degree in 1999Publications: more than 250 full and short scientific papers<br />
TEESALU, SELMA Date <strong>of</strong> birth: 15.Dec. 1930Gender: FemaleCitizenship: EstoniaAddress: Sõpruse<br />
pst. 3-13,Tartu 50605, EstoniaEducational history: 1954 Medical Faculty <strong>of</strong> Tartu UniversityAcademic<br />
degrees (with year and university): Ph.D 1965 University <strong>of</strong> TartuM.D 1975 Universty <strong>of</strong> TartuEmployment<br />
and pr<strong>of</strong>essional experience: 1953 <strong>Department</strong> <strong>of</strong> Physiology Universty <strong>of</strong> Tartu<br />
1967 Assist. Pr<strong>of</strong>.1977-1995 Pr<strong>of</strong>.1995 Pr<strong>of</strong>. EmeritusAdministrative experience: noneHonours and<br />
awards: medal <strong>of</strong> <strong>the</strong> Faculty <strong>of</strong> Medicine, Universty <strong>of</strong> Tartu 1996Membership in academic and scientific<br />
societies: Estonian physiologiacal Society; Estonian Society <strong>of</strong> Osteoporosis; Estonian Society<br />
<strong>of</strong> Nutritional SciensiesCurrent research program and grants: Investigation <strong>of</strong> OsteoporosisSupervision<br />
<strong>of</strong> dissertations: Ph.D Meeli Roosalu, 1984Publications: 162<br />
KINGISEPP, PEET-HENN 2. Date <strong>of</strong> birth: 10 December 19363. Gender: male4. Citizenship: Estonian5.<br />
Address: <strong>Department</strong> <strong>of</strong> Physiology Faculty <strong>of</strong> Medicine University <strong>of</strong> Tartu, Ravila 19, Tartu<br />
50411 ESTONIA6. Educational history: 1954-1961 University <strong>of</strong> Tartu, Faculty <strong>of</strong> Medicine7. Academic<br />
degrees: PhD 1973 Regulation <strong>of</strong> external respiration during intermittent and continuous<br />
physical exercise8. Employment and pr<strong>of</strong>essional experience: 1963-1970 researcher at <strong>the</strong> laboratory<br />
<strong>of</strong> biophysics, University <strong>of</strong> Tartu,1970-73 PhD student at <strong>the</strong> Dept. <strong>of</strong> Physiology, 1973-75 assistant<br />
at <strong>the</strong> Dept. <strong>of</strong> Sports Medicine and Rehabilitation, 1975-78 sen. lecturer at <strong>the</strong> Dept. <strong>of</strong> Physiology,<br />
from 1980 associate pr<strong>of</strong>essor at <strong>the</strong> Dept. <strong>of</strong> Physiology9. Administrative experience: Participation<br />
in EU Tempus Programme Project S_JEP-12402-9710. Honors/awards: medal <strong>of</strong> <strong>the</strong> Faculty<br />
<strong>of</strong> Medicine, University <strong>of</strong> Tartu 199711. Membership in academic and scientific societies: member<br />
<strong>of</strong> Executive Committe <strong>of</strong> Estonian Society <strong>of</strong> Biomedical Engineering and Medical Physics and<br />
member <strong>of</strong> <strong>the</strong> Estonian Physiological Society12. Current research program and grant: Studies on<br />
respiratory and cardiovascular physiology, automatization <strong>of</strong> lung function studies.Target financed<br />
project - Investigation <strong>of</strong> external respiration and circulation in children and adults TARFS<br />
0417Estonian Science Foundation grant No 4363 Lung function studies in Estonian schoolchildren<br />
Studies on dynamic and static lung parameters and diffusing capacity in adults13. Supervision <strong>of</strong> dissertations<br />
Jana Kivastik Lung function in Estonian Schoolchildren: relationship with anthropometric indices<br />
and respiratory symptoms, reference values for dynamic spirometry Tartu 200014.<br />
Publications: 139 publications<br />
SOOSAAR, ANDRES Date <strong>of</strong> birth: July 2, 1961Gender: maleCitizenship: EstoniaAddress: <strong>Biomeedikum</strong>,<br />
Dept. Physiology, University <strong>of</strong> Tartu, 19 Ravila Street, Tartu 50411, EstoniaEducational history:<br />
University <strong>of</strong> Tartu, Medical School, MD, 19851985-88 - Postgraduate Student, <strong>Department</strong>s <strong>of</strong><br />
Pharmacology and Physiology, University <strong>of</strong> TartuAcademic degrees (with year and university): Can-<br />
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SECTION I: APPENDIXES<br />
didate <strong>of</strong> Medical Sciences, 1989, University <strong>of</strong> TartuEmployment and pr<strong>of</strong>essional experience:<br />
1988-1989 - Research Scientist, Psychopharmacology Lab, Institute <strong>of</strong> General and Molecual Pathology,<br />
University <strong>of</strong> Tartu1989-94 - Lecturer, <strong>Department</strong> <strong>of</strong> Physiology, University <strong>of</strong> TartuSince 1994 --<br />
Associate Pr<strong>of</strong>essor, Dept. Physiology, University <strong>of</strong> TartuJanuary-August 2000 - Research Scientist,<br />
Indiana University Bloomington, USA.Administrative experience: 1988-99 - A person in charge <strong>of</strong><br />
<strong>the</strong> Tempus project S_JEP-12402-97 "Baltic Biomedical Engineering and Physics Courses" in <strong>the</strong> University<br />
<strong>of</strong> TartuHonours and awards: -Membership in academic and scientific societies: Estonian<br />
Physiological Society; Association for <strong>the</strong> Scientific Study <strong>of</strong> ConsciousnessCurrent research program<br />
and grants: Study <strong>of</strong> neural correlates <strong>of</strong> consciousnessSupervision <strong>of</strong> dissertations: -<br />
Publications: 55 scientific papers and short communications<br />
LANG, AAVO Date <strong>of</strong> birth: 15.06.1964Gender: MaleCitizenship: EstonianAddress: University <strong>of</strong><br />
Tartu, <strong>Department</strong> <strong>of</strong> Physiology, Ravila 19, 50411 Tartu, EstoniaEducational history: Medical Faculty,<br />
University <strong>of</strong> Tartu 1982-1988Academic degrees (with year and university): Dr. med. in 1995,<br />
University <strong>of</strong> TartuEmployment and pr<strong>of</strong>essional experience:University <strong>of</strong> Tartu, Dept Science,<br />
laboratorian, 1988-1989University <strong>of</strong> Tartu, Dept Science, junior scientist, 1990-1992University <strong>of</strong><br />
Tartu, IGMP, scientist, 1992University <strong>of</strong> Tartu, Dept Physiol, assistant, 1992-1997University <strong>of</strong> Tartu,<br />
Deptt Physiol, senior assistant, 1997 -2001University <strong>of</strong> Tartu, Deptt Physiol, assistant pr<strong>of</strong>essor,<br />
2001- ...Trainining at University <strong>of</strong> Helsinki 1992-1994, Nottingham University 1996,<br />
etcAdministrative experience:Since 2000 – responsible person dealing with graduate studies in<br />
Medical Faculty;Member <strong>of</strong> organization committee <strong>of</strong> several scientific meetingsHonours and<br />
awards:Membership in academic and scientific societies: Scandinavian Society for Laboratory<br />
Animal Science – board member, Estonian Society for Laboratory Animal Science – president, Member<br />
in Estonian Society <strong>of</strong> Physiology and Estonian Society <strong>of</strong> Pharmacology. Editorial Board member<br />
<strong>of</strong> Scandinavian Journal <strong>of</strong> Laboratory Animal ScienceCurrent research program and grants:Grant<br />
from Estonian Science Foundation, grant holder (1998-2001): Relation <strong>of</strong> depression and suicide to<br />
serotonin transporter gene polymorphismSupervision <strong>of</strong> dissertations: currently 1 PhD student<br />
(Eduard Maron) and 1 MSc student (Anne Must)Publications: 28 (cited in CC), 100 (including abstracts<br />
and o<strong>the</strong>r papers)<br />
PERT, VELLO 2. Date <strong>of</strong> birth:03.04.19403. Gender:Male4. Citizenship:Estonian5. Address:Dept. <strong>of</strong><br />
Physiology, University <strong>of</strong> Tartu, Ravila 19, Tartu 50411, Estonia6. Educational history:1963-1968<br />
University <strong>of</strong> Tartu, Faculty <strong>of</strong> Biology7. Academic degrees (with year and university):Cand. Biol.<br />
1990, University <strong>of</strong> Tartu8. Employment and pr<strong>of</strong>essional experience:1968-1990 assistant, 1990-<br />
2001 senior assistant at <strong>the</strong> Dept. <strong>of</strong> Physiology, University <strong>of</strong> Tartu9. Administrative<br />
experience:none10. Honours and awards:none11. Membership in academic and scientific<br />
societies:Estonian Physiological Society12. Current research program and grants:Target financed<br />
project No. TARFS 0417: Investigation <strong>of</strong> external respiration and circulation in children and<br />
adultsGrant No. 4363 from <strong>the</strong> Estonian Science Foundation: Studies on dynamic and static lung<br />
parameters and diffusing capacity in adults13. Supervision <strong>of</strong> dissertations:none14. Publications:<br />
20 scientific publications<br />
VAASA, IVAR-OLAVI 2. Date <strong>of</strong> birth: 19. 10. 1941.3. Gender: Male4. Citizenship: Estonian5.<br />
Address: Ravila 19, 50411 Tartu, <strong>Department</strong> <strong>of</strong> physiology6. Educational history: Medical Faculty,<br />
University <strong>of</strong> Tartu 1963-19697. Academic degrees (with year and university): none8. Employment<br />
and pr<strong>of</strong>essional experience:University <strong>of</strong> Tartu, Dept. physiol., assistant, 1978-1987I Medical<br />
Insitute <strong>of</strong> Sankt Peterburg, Faculty <strong>of</strong> Raise <strong>of</strong> Qualification, 1983University <strong>of</strong> Tartu, Dept. Physiol.,<br />
senior assistant, 1987 - I Medical Institute <strong>of</strong> Moscow, <strong>Department</strong> <strong>of</strong> Physiology and Refresher<br />
Courses for Lecturer <strong>of</strong> High School, 19889. Administrative experience: Director <strong>of</strong> <strong>the</strong> Medical<br />
School <strong>of</strong> Tartu, 1972-197810. Honours and awards: 11. Membership in academic and scentific<br />
societes: Estonian Society <strong>of</strong> Physiology, member;Estonian Society <strong>of</strong> Osteoporosis, member; Estonian<br />
Society <strong>of</strong> Nutritional Science, member;12. Current research program and grants: Grant from<br />
Science Foundation (1999 - 2001): The prevention <strong>of</strong> osteoporosis in female students 20-25 years old<br />
<strong>of</strong> <strong>the</strong> Tartu University and Estonian Agricultural Unversity.13. Supervision <strong>of</strong> dissertations: none14.<br />
Publications: 42 (incl. abstracts)<br />
KIVASTIK, JANA Date <strong>of</strong> birth: 28 January, 1967Gender: femaleCitizenship: EstonianAddress: Dept.<br />
<strong>of</strong> Physiology, University <strong>of</strong> Tartu, Ravila 19, Tartu 50411, EstoniaEducational history: 1985-1992<br />
University <strong>of</strong> Tartu, Faculty <strong>of</strong> MedicinePhD student at <strong>the</strong> Dept. <strong>of</strong> Physiology, University <strong>of</strong> TartuAcademic<br />
degrees (with year and university): Dr.Med. 2000 University <strong>of</strong> Tartu8. Employment and<br />
pr<strong>of</strong>essional experience: Dept. <strong>of</strong> Physiology, University <strong>of</strong> Tartu, Assistant from 19949. Administrative<br />
experience: member <strong>of</strong> <strong>the</strong> organizing committee <strong>of</strong> following meetings: "I Estonian-Finnish<br />
88
PHYSIOLOGY<br />
meeting on physiology" 1992, "Baltic/Scandinavian physiology meeting" 1993,"Laboratory animals in<br />
biomedical research" 1994, "Rudolf Buchheim Conference" 1995,"Research, animals and welfare"<br />
1997.10. Honours and awards: none11. Membership in academic and scientific societies: Estonian<br />
Physiological Society, Europen Respiratory Society12. Current research program and<br />
grants:Target financed project No. TARFS 0417: Investigation <strong>of</strong> external respiration and circulation in<br />
children and adults Grant No. 4363 from <strong>the</strong> Estonian Science Foundation: Studies on dynamic and<br />
static lung parameters and diffusing capacity in adults 13. Supervision <strong>of</strong> dissertations: none14.<br />
Publications: 29 scientific publications<br />
RÜNKORG, KERTU 2. Date <strong>of</strong> birth:17.08.19733. Gender:Female4. Citizenship:Estonian5. Address:<br />
Dept. <strong>of</strong> Physiology, University <strong>of</strong> Tartu, Ravila 19, Tartu 50411, Estonia6. Educational history:1997<br />
University <strong>of</strong> Tartu, Faculty <strong>of</strong> Medicine7. Academic degrees (with year and university): none8.<br />
Employment and pr<strong>of</strong>essional experience:1998-2001 assistant University <strong>of</strong> Tartu9.<br />
Administrative experience:none10. Honours and awards:none11. Membership in academic and<br />
scientific societies: none12. Current research program and grants: none13. Supervision <strong>of</strong><br />
dissertations:none14. Publications: none<br />
VEDRU, JÜRI Date <strong>of</strong> birth:Dec. 24, 1948Gender:maleCitizenship:EstonianAddress:Nooruse 9-312,<br />
EE 50411 Tartu, ESTONIAEducational history:1972: Graduated from <strong>the</strong> University <strong>of</strong> Tartu (speciality<br />
- <strong>the</strong>oretical physics) cum laude. 1972-1981: Worked as a research assistant at <strong>Department</strong> <strong>of</strong><br />
Sports Medicine (biomedical engineering - BME), University <strong>of</strong> Tartu (UT). 1982-1984: Post graduate<br />
study at Moscow Bakulev Institute <strong>of</strong> Cardiovascular Surgery (medical cybernetics) at Pr<strong>of</strong>. V.A. Lischouk.<br />
1988: Defending PhD (according to SU classification: Candidate <strong>of</strong> Biology on Normal Physiology)<br />
<strong>the</strong>sis at <strong>the</strong> University <strong>of</strong> Tartu. Title: “Ma<strong>the</strong>matical Model <strong>of</strong> Cardiovascular System for<br />
Simulation Tasks <strong>of</strong> <strong>the</strong> Human Circulation”. 1985-1997: Working at <strong>the</strong> Institute <strong>of</strong> General and Molecular<br />
Pathology (IGMP) <strong>of</strong> UT, at first as an Engineer, <strong>the</strong>n as Researcher and Senior Researcher.<br />
From 1989 to 1997 leader <strong>of</strong> a BME research Group. From 1994 up today: simultaneously half-time<br />
Associate Pr<strong>of</strong>essor at <strong>the</strong> Institute for Institute <strong>of</strong> Materials Science ( up to 1995 named <strong>the</strong> Institute<br />
for Teaching Physics) <strong>of</strong> UT, now as <strong>the</strong> half-time Associate Pr<strong>of</strong>essor <strong>of</strong> Medical Physics. From 1994<br />
up today: participating in teaching and organising biomedical engineering and medical physics branch<br />
<strong>of</strong> <strong>the</strong> Applied Physics speciality at <strong>the</strong> Faculty <strong>of</strong> Physics and Chemistry. From 1997 up today: working<br />
at <strong>the</strong> Institute <strong>of</strong> Physiology (ARFS) <strong>of</strong> UT, as a half-time Senior Researcher. Academic degrees<br />
(with year and university):1988: Candidate <strong>of</strong> Biology (according to SU classification; equivalent to<br />
PhD) on Normal Physiology, defended at <strong>the</strong> University <strong>of</strong> Tartu with <strong>the</strong> presence <strong>of</strong> supplementary<br />
experts from Moscow; prepared at <strong>the</strong> Moscow Bakulev Institute <strong>of</strong> Cardiovascular Surgery. Employment<br />
and pr<strong>of</strong>essional experience:Half-time Senior Researcher (Research Fellow), Institute <strong>of</strong><br />
Physiology, UT Half-time Docent (Associate Pr<strong>of</strong>essor) <strong>of</strong> Medical Physics, Institute <strong>of</strong> Materials Science,<br />
UTIn 1989-1993: Occasional lecturing <strong>of</strong> some free courses on ma<strong>the</strong>matical modelling, medical<br />
signal processing and medical electronics for <strong>the</strong> students <strong>of</strong> <strong>the</strong> UT, participation in conducting <strong>of</strong><br />
practical classes on medical physics for students <strong>of</strong> <strong>the</strong> medical specialities <strong>of</strong> <strong>the</strong> UT.From 1994 up<br />
today: Regular teaching <strong>of</strong> physics to students <strong>of</strong> <strong>the</strong> medical specialities <strong>of</strong> <strong>the</strong> UT, at first for Russian<br />
branch, afterwards for Estonian and English branches also. From 1994 up today: Participation in organisation<br />
<strong>of</strong> Biomedical Engineering and Medical Physics branch <strong>of</strong> <strong>the</strong> Applied Physics speciality at<br />
<strong>the</strong> Faculty <strong>of</strong> Physics and Chemistry, UT, and lecturing to those students. List <strong>of</strong> courses lectured or<br />
participated in lecturing by J. Vedru in 1994-2001:FKEF.02.028 Biomedical instrumentation and<br />
methods FKEF.02.049 Methods and Instrumentation <strong>of</strong> Medical Diagnostics and Therapy<br />
FKFD.01.040 Ma<strong>the</strong>matical Methods in Biomedicine (closed in 1997)FKMF.01.012 Medical Physics<br />
(closed in 1998)FKMF.01.025Linear Electrical Circuits FKMF.01.046Introduction to Biophysics<br />
FKMF.01.047Introduction to Medical ElectronicsFKMF.01.049Living SystemsAdministrative experience:<br />
1989-1997: Head <strong>of</strong> BME Research Group at <strong>the</strong> Institute <strong>of</strong> General and Molecular Pathology,<br />
UT.Honours and awards:1978: (toge<strong>the</strong>r with L.-H. Humal as <strong>the</strong> first author) Small Golden Medal <strong>of</strong><br />
<strong>the</strong> Exhibition <strong>of</strong> <strong>the</strong> Achievements <strong>of</strong> <strong>the</strong> USSR National Economy for development <strong>of</strong> Cardiotachograph<br />
UT-7404.Current research program and grants:1999-2001: Estonian Science Foundation<br />
grant No 3914 “Investigation <strong>of</strong> <strong>the</strong> Foucault Cardiography Method.” Funding 65000 EEK (in 1999)+<br />
61000 EEK (in 2000)+ (? for 2001)2000-2001: Participation in Estonian Science Foundation grant No<br />
4449 “User-Oriented Model <strong>of</strong> Distributed Systems Based on ATM Network for Solution <strong>of</strong> Large Applications.”<br />
Funding 50000 EEK (in 2000) + (? for 2001) 2000 - : Participation in research project<br />
“DynAMo: Dynamic Adaptive Modeling <strong>of</strong> <strong>the</strong> Human Body conducted by pr<strong>of</strong>. Jaakko Malmivuo,<br />
leader <strong>of</strong> <strong>the</strong> consortium, Tampere University <strong>of</strong> Technology, etc. (Total funding: 2.800.000 FIM) Supervision<br />
<strong>of</strong> dissertations:2000: Master Theses <strong>of</strong> Boriss Mahrov ("Verification <strong>of</strong> <strong>the</strong> Method for<br />
Calculation <strong>of</strong> Foucault Cardiographic Eddy Current Fields"), Sergei Malchenko ("Model <strong>of</strong> Cyclic<br />
Variation <strong>of</strong> <strong>the</strong> Human Heart Shape at Normal Functioning"), Konstantin Skaburskas ("A Mesh Model<br />
89
SECTION I: APPENDIXES<br />
<strong>of</strong> <strong>the</strong> Eddy Current Fields <strong>of</strong> <strong>the</strong> Foucault Cardiography: Calculation Using <strong>the</strong> Node Voltages<br />
Method"), Jaanus Trolla ("Building and Investigation <strong>of</strong> an Exemplar <strong>of</strong> Foucault Cardiograph").Diploma<br />
work <strong>of</strong> Priit Lilleleht (1992), Bachelor works <strong>of</strong> Eiko Keeman (1995), Anatoli Vladimirov<br />
(1996), Sergei Malchenko (1997), Boris Kudimov (1997), Boriss Mahrov (1998), Olesja Makarova<br />
(2000). Topic <strong>of</strong> all <strong>the</strong> bachelor and doploma works belongs to physics, more specifically to medical<br />
physics and biomedical engineering.Publications:Total number <strong>of</strong> publications 28.<br />
RAAMAT, REIN Date <strong>of</strong> birth:16.09.1941Gender:maleCitizenship:EstonianAddress:146 Aardla St<br />
Tartu 51014 EstoniaEducational history:1960-1965 Tallinn Technical University, Faculty <strong>of</strong> Automatics,<br />
undergraduate studies, 5 Ehitajate St., Tallinn, EstoniaPhD level studies in Biomedical Engineering,<br />
Leningrad Electrotechnical Institute, 5 Pr<strong>of</strong>. Popov St., St. Petersbourg, Russiamanagement<br />
courses at <strong>the</strong> Estonian Management School, 15 Sutiste St., Tallinn, EstoniaRagnar Granit Institute<br />
course on biomagnetism, University <strong>of</strong> Tartu, 18 Ülikooli Str., Tartu 51014, Estonia 1999 King’s College<br />
London, Linkoping University, courses on BME and MPAcademic degrees (with year and university):PhD<br />
in Biomedical Engineering, 1977, Leningrad Electrotechnical Institute, 5 Pr<strong>of</strong>. Popov St.,<br />
St. Petersbourg, Russia, ‘Evaluation <strong>of</strong> <strong>the</strong>rmal methods for stereotaxic neurosurgery’Employment<br />
and pr<strong>of</strong>essional experience:engineer, Technology and Design Office, University <strong>of</strong> Tartu, 18<br />
Ülikooli Str., Tartu , Estoniahead <strong>of</strong> group, Laboratory <strong>of</strong> Biophysics and Electrophysiology, University<br />
<strong>of</strong> Tartu, 18a Ülikooli Str., Tartu , Estoniahead designer, Design Office <strong>of</strong> <strong>the</strong> Estonian Academy <strong>of</strong><br />
Sciences, 185 Riia Str., Tartu , Estonia.senior researcher, <strong>Department</strong> <strong>of</strong> Physiology, University <strong>of</strong><br />
Tartu, 18 Ülikooli Str., Tartu 51014, EstoniaAdministrative experience:1979-1989 head designer1989-1992<br />
head <strong>of</strong> <strong>the</strong> Laboratory <strong>of</strong> BiophysicsHonours and awards:Government award <strong>of</strong> <strong>the</strong><br />
Counsel <strong>of</strong> Ministries <strong>of</strong> <strong>the</strong> S.U. for ‘Excimer laser spectrometers’ in 1986Membership in academic<br />
and scientific societies:Vice Chairman <strong>of</strong> <strong>the</strong> Estonian Society for Biomedical Engineering and<br />
Medical Physics, Member <strong>of</strong> <strong>the</strong> General Assembly <strong>of</strong> <strong>the</strong> International Union for Physical and Engineering<br />
Sciences in Medicine (UPESM)Current research program and grants:Lectures and practical<br />
works in biophysics to <strong>the</strong> first year students <strong>of</strong> <strong>the</strong> Faculty <strong>of</strong> Medicine; Lectures and workshops in<br />
BME to <strong>the</strong> fourth year students <strong>of</strong> <strong>the</strong> Faculty <strong>of</strong> Physics and Chemistry;‘Cardiovascular autonomic<br />
regulation and lung function interaction in various age groups’ (PROJECT TARFS 0417);1994-1997,<br />
Grant <strong>of</strong> <strong>the</strong> Estonian Science Foundation (GARFS1064), ‘Improvements in <strong>the</strong> <strong>the</strong>rmal clearance<br />
method for measurement <strong>of</strong> skin blood flow’;1998-2001, Grant <strong>of</strong> <strong>the</strong> Estonian Science Foundation<br />
(GARFS3287), ‘Blood pressure measurements using differential oscillometric technique’;1996, Nordic<br />
Scholarship Grant, ‘Comparison <strong>of</strong> skin blood flow meters’Supervision <strong>of</strong> dissertations:B.Kudimov ‘<br />
Blood flow registration applying TC-method’, 1999, MSc <strong>the</strong>ses, University <strong>of</strong> TartuJ.Talts ‘Noninvasive<br />
blood pressure measurement using differential oscillometric method’, 1999, MSc <strong>the</strong>ses, University<br />
<strong>of</strong> Tartusupervision <strong>of</strong> two PhD students.Publications: 87<br />
JAGOMÄGI, KERSTI Date <strong>of</strong> birth: 21.12.1942Gender: femaleCitizenship: EstonianAddress: 118-73<br />
Aardla St., Tartu 50415, EstoniaEducational history: University <strong>of</strong> Tartu, Faculty <strong>of</strong> Medicine<br />
(1967)Academic degrees (with year and university): PhD in normal physiology, 1975, University <strong>of</strong><br />
Tartu, Faculty <strong>of</strong> Medicine Employment and pr<strong>of</strong>essional experience: 1964 –1967 nurse, Tartu<br />
University Hospital; 1967-1968 physician, Tartu University Hospital; 1968-1971 junior scientific researcher,<br />
Lab. <strong>of</strong> Biophysics and Electrophysiology, Univ. <strong>of</strong> Tartu; 1971-1974 postgraduate studies,<br />
Dept. <strong>of</strong> Physiology, Univ. <strong>of</strong> Tartu; 1975-1992 researcher, head <strong>of</strong> group, Lab. <strong>of</strong> Biophysics and<br />
Electrophysiology, Univ. <strong>of</strong> Tartu; 1992-2001 senior researcher, Dept. <strong>of</strong> Physiology, Univ. <strong>of</strong> Tartu;<br />
1999 King’s College London, Linkoping University, courses on BME and MPAdministrative experience:Honours<br />
and awards:Membership in academic and scientific societies: Estonian Physiological<br />
Society, secretary; Estonian Society <strong>of</strong> Hypertension, member; Estonian Society <strong>of</strong> Biomedical Engineering<br />
and Medical Physics, memberCurrent research program and grants: lectures and practical<br />
works in physiology to second year students <strong>of</strong> <strong>the</strong> Faculty <strong>of</strong> Medicine; lectures and practical<br />
works in biophysics to first year students <strong>of</strong> <strong>the</strong> Faculty <strong>of</strong> Medicine; ‘Cardiovascular autonomic<br />
regulation and lung function interaction in various age groups’ (PROJECT TARFS 0417); ‘Continuous<br />
noninvasive blood pressure measurement by differential oscillometric method’ (grant 3287 <strong>of</strong> Estonian<br />
Scientific Foundation)Supervision <strong>of</strong> dissertations:Publications: 81<br />
KÕKS, SULEV University <strong>of</strong> Tartu, <strong>Department</strong> <strong>of</strong> Physiology, researcher Date <strong>of</strong> birth1972 Educational<br />
historyUniversity <strong>of</strong> Tartu, physician Research and pr<strong>of</strong>essional experience, institutional affiliation and<br />
postdoctoral research training1993-1996 technician University <strong>of</strong> Tartu (UT), <strong>Department</strong> <strong>of</strong><br />
Physiology;1996-1999 researcher UT Depart. Physiology; 1995-1999 Ph.D. student IMCB University<br />
<strong>of</strong> Tartu;1997 visiting scientist at <strong>the</strong> University <strong>of</strong> Kuopio; 1999 up to now researcher at <strong>the</strong> Dep. <strong>of</strong><br />
Physiology, UT;01.-11.05.1994. course "Laboratory Animals in Biomedical research" University <strong>of</strong><br />
Tartu and Scad-LASA03.-08.06.1996. course "Current Concepts and Methods in Neurotoxicology"<br />
90
PHYSIOLOGY<br />
University <strong>of</strong> Kuopio;visits to University <strong>of</strong> Helsinki (1 month) and to University <strong>of</strong> Kuopio (2<br />
months);16.08.-28.08.1999. "EMBL/FENS Mouse Transgenic Course" University <strong>of</strong>Edinburgh<br />
Academic degreesPh.D., molecular biomedicine, "CCK-induced anxiety in rats: influence <strong>of</strong><br />
environmental stimuli and involvement <strong>of</strong> endopioid mechanisms and serotonin" Honors/awardsnone<br />
Research – administrative experiencemember <strong>of</strong> <strong>the</strong> Estonia Physiology Society and <strong>the</strong> European<br />
Neuroscience Association, 1997 was involved in <strong>the</strong> organising <strong>of</strong> <strong>the</strong> international course "Laboratory<br />
Animals in Biomedical Research" at Tartu Current research programrole <strong>of</strong> neuropeptides in <strong>the</strong><br />
generation <strong>of</strong> negative emotions, especially involvement <strong>of</strong> CCK in <strong>the</strong> anxiogenesis Current grant<br />
fundingnone Dissertations advisednone<br />
Curriculum Vitae<strong>Name</strong>: Vallo VolkeDate <strong>of</strong> birth: April 30, 1971Gender: maleCitizenship: EstonianAddress:<br />
<strong>Biomeedikum</strong>, Dept. Physiology, University <strong>of</strong> Tartu, 19 Ravila Street, Tartu 50411, EstoniaEducational<br />
history: University <strong>of</strong> Tartu, Medical School, MD, 19951995-98 - Postgraduate Student,<br />
<strong>Department</strong><strong>of</strong> Molecular and Cell Biology, University <strong>of</strong> Tartu1998-1999- Inernship at Tallinn<br />
Pelgulinna Hospital and Tartu Maarjamõisa HospitalAcademic degrees (with year and university):<br />
PhD, 1999, University <strong>of</strong> TartuEmployment and pr<strong>of</strong>essional experience: 1999- Research scientist ,<br />
<strong>Department</strong> <strong>of</strong> Physiology1998-1999 Senior House Officer, Tallinn Pelgulinna Hospital and Tartu<br />
Maarjamõisa Hospital1998 (6 months) visiting research scientist at <strong>Department</strong> <strong>of</strong> Biological Psychiatry,<br />
University <strong>of</strong> Aarhus, Denmark1996-1998 Research scientist (half-time), <strong>Department</strong> <strong>of</strong> PhysiologyAdministrative<br />
experience: Honours and awards: -Student Research Award <strong>of</strong> Estonian Academy<br />
<strong>of</strong> SciencesResearch Award <strong>of</strong> Ministry <strong>of</strong> EducationMembership in academic and scientific societies:<br />
Estonian Physiological SocietyCurrent research program and grants: Role <strong>of</strong> Nitric Oxide in<br />
<strong>the</strong> regulation <strong>of</strong> anxiety and depression.Supervision <strong>of</strong> dissertations: -Publications: 14 scientific<br />
publications in peer-reviewed journals.<br />
91
MICROBIOLOGY<br />
<strong>Name</strong> <strong>of</strong> <strong>the</strong> <strong>Department</strong>: <strong>Department</strong> <strong>of</strong> Medical Microbiology<br />
Head <strong>of</strong> <strong>the</strong> <strong>Department</strong>: Pr<strong>of</strong>essor Marika Mikelsaar<br />
<strong>Name</strong> <strong>of</strong> <strong>the</strong> Chair: Medical Microbiology and Virology<br />
Head <strong>of</strong> <strong>the</strong> <strong>Department</strong>: Pr<strong>of</strong>essor Marika Mikelsaar<br />
Subject codes: ARMB.01.009; ARMB.01.012; ARMB.01.013;<br />
ARMB.01.01.14; ARMB.01.015; ARMB.01.020;<br />
ARMB.01.027; ARMB.01.033<br />
I. CONTENT OF THE TEACHING<br />
The aim <strong>of</strong> our department is to teach on <strong>the</strong> graduate level <strong>the</strong> medical microbiology<br />
to <strong>the</strong> medical, dentistry and pharmacy students in order to provide<br />
knowledge for solving <strong>the</strong> problems <strong>of</strong><br />
1. common, hospital and emerging infectious diseases, concerning <strong>the</strong>ir epidemiology,<br />
pathogenesis, diagnostics, treatment and prophylaxis in <strong>the</strong>ir<br />
praxis;<br />
2. coexistence with <strong>the</strong> huge burden <strong>of</strong> indigenous microorganisms in our<br />
body and environment for successful protection <strong>of</strong> <strong>the</strong> health <strong>of</strong> a particular<br />
person and <strong>the</strong> population.<br />
1. Describe shortly <strong>the</strong> main study and student evaluation methods applied at<br />
<strong>the</strong> department.<br />
In <strong>the</strong> department <strong>the</strong> main study methods are:<br />
• lectures: obligate courses in general, special, clinial microbiology and elective<br />
courses for different problems <strong>of</strong> microbiology<br />
• seminars<br />
• laboratory praxis<br />
• seminar + conference<br />
• directed self-education<br />
• students research work in <strong>the</strong> department<br />
For evaluation <strong>the</strong> oral and written exam and +/- tests are used.<br />
2. How have <strong>the</strong> aims and objectives described in <strong>the</strong> curriculum changed<br />
during <strong>the</strong> past five years?<br />
The described aims have been traditionally characteristic for teaching <strong>of</strong> microbiology<br />
during many years in University <strong>of</strong> Tartu. Yet, during <strong>the</strong> last 2<br />
years <strong>the</strong> aims <strong>of</strong> microbiology teaching have been increasingly oriented towards<br />
more intense teaching <strong>of</strong> students in clinical than in systematic microbiology.<br />
Our new curriculum from 1998 aims to provide <strong>the</strong> students with con-<br />
93
SECTION I: SELF-EVALUATION<br />
ceptual framework for new diagnostic and antimicrobial treatment possibilites,<br />
and <strong>the</strong> understandig <strong>of</strong> rational immunoprotection.<br />
In <strong>the</strong> recent medical curriculum <strong>of</strong> Tartu University <strong>the</strong> teaching <strong>of</strong> microbiology<br />
has been changed from separate teaching <strong>of</strong> systematic microbiology (IV,<br />
V semester) and clinical microbiology (XI semester) to converge into medical<br />
microbiology (III and IV semester). Compared to <strong>the</strong> earlier curriculum, more<br />
emphasis has been paid for problem-based teaching and solving <strong>of</strong> clinical<br />
situations, caused by infectious agents.<br />
The students have been provided with Estonian language teaching material:<br />
two Estonian Textbooks <strong>of</strong> Medical Microbiology I and II (1998, 2000), and<br />
also a Handbook <strong>of</strong> clinical microbiology (1998) have been written by <strong>the</strong> staff<br />
.<br />
3. Describe <strong>the</strong> strengths and weaknesses <strong>of</strong> <strong>the</strong> teaching in your department.<br />
Strengths<br />
1. Medical microbiology has been accepted by students as an interesting<br />
subject, widely needed in everyday medical practice and also for health<br />
protection <strong>of</strong> young, adolescent, adult and senile people.<br />
2. Well educated staff (all have MD and PhD degrees) is motivated for<br />
teaching and this motivation is appreciated by students. Our teachers are<br />
very popular among students for <strong>the</strong>ir skills and willingness for teaching.<br />
3. The staff has got wide international education and also <strong>the</strong>ir pr<strong>of</strong>essional<br />
skills and language knowledge are good. The international and Russian<br />
student's teaching is successfully ongoing.<br />
4. The educational staff is well motivated to bring new methods into <strong>the</strong><br />
teaching. The textbooks were written by <strong>the</strong> educational staff.<br />
5. Numerous experts <strong>of</strong> laboratory diagnostics <strong>of</strong> United Laboratories <strong>of</strong> Tartu<br />
University with PhD degree and also <strong>the</strong> PhD students have been involved<br />
in teaching <strong>of</strong> medical students. Modern aspects <strong>of</strong> microbiological diagnostics<br />
are brought to <strong>the</strong> knowledge <strong>of</strong> students on one hand, and on <strong>the</strong><br />
o<strong>the</strong>r hand, <strong>the</strong> same methods are introduced quicker by <strong>the</strong> microbiologists<br />
into <strong>the</strong>ir everyday work.<br />
Weaknesses<br />
1. For virology, mycology and parasitology teaching <strong>the</strong>re is no Estonian textbook<br />
available yet. The writing is going on, yet in Estonia. In <strong>the</strong> field <strong>of</strong><br />
medical mycology and parasitology no well-trained specialists with an academic<br />
degree are available<br />
2. Though <strong>the</strong> microscopic slides <strong>of</strong> main infectious agents are used in <strong>Department</strong>,<br />
no collections <strong>of</strong> typical cases, slides and videos are available for<br />
student's self-assessment.<br />
94<br />
3. The area <strong>of</strong> medically important microorganisms is very wide and continuously<br />
increasing, which makes hard and subjective <strong>the</strong> selection <strong>of</strong> dis-
MICROBIOLOGY<br />
cussed cases and topics. The co-ordination with infectious diseases chair<br />
is minimal.<br />
4. Describe <strong>the</strong> innovations in your teaching.<br />
1. During lectures and seminars <strong>the</strong> Data projector and Power Point lectures<br />
with some Photos <strong>of</strong> clinical cases are used. The students (international,<br />
Russian) are frequently provided with handouts <strong>of</strong> lectures as <strong>the</strong>y do not<br />
have <strong>the</strong> textbook written by us.<br />
2. The Estonian textbooks and handbook are provided with a lot <strong>of</strong> tables and<br />
figures, reflecting both global and local data <strong>of</strong> infectious epidemiology and<br />
microbial drug resistance.<br />
3. For practical interactive labwork two separate leaflet books have been published<br />
(T. Karki, T. Brilene, M. Mikelsaar. Practical works in medical microbiology,<br />
I and II. Tartu, 1999). In <strong>the</strong>se books <strong>the</strong> plan <strong>of</strong> <strong>the</strong> practical work,<br />
its items have been proposed for acquintance, <strong>the</strong> practical works described<br />
and for interactive work <strong>the</strong> diagnostic formulars and <strong>the</strong> conclusions<br />
must be drawn by <strong>the</strong> students <strong>the</strong>mselves.<br />
4. An innovative conference-seminar has been applied for teaching <strong>of</strong> mycology.<br />
The <strong>the</strong>mes <strong>of</strong> clinically important fungal infections where divided to<br />
students who <strong>the</strong>mselves searched <strong>the</strong> data and made presentations using<br />
<strong>the</strong> material from different textbooks, papers and Internet. After each presentation<br />
<strong>the</strong> o<strong>the</strong>r students (opponents) started <strong>the</strong> discussion and evaluated<br />
<strong>the</strong> presentation and knowledge.<br />
5. The exam <strong>of</strong> medical microbiology has been divided for 2 parts: general<br />
microbiology and altoge<strong>the</strong>r <strong>the</strong> bacteriology, virology, mycology and parasitology.<br />
6. Through <strong>the</strong> whole curriculum <strong>the</strong> new elective problem-oriented courses<br />
are <strong>of</strong>fered for students.<br />
Hospital infections, Most important for Estonia infections: spread, pathogenesis,<br />
diagnostics and control, Gynaecological infections, Stomatological<br />
infections, Antimicrobial drugs in clinical practice, Role <strong>of</strong> probiotics in<br />
medicine, History <strong>of</strong> microbiology.<br />
7. Scientific achievements in molecular mechanisms <strong>of</strong> infectious diseases<br />
and molecular dignostics <strong>of</strong> <strong>the</strong> world and colleagues <strong>of</strong> department are<br />
reported on <strong>the</strong> lectures<br />
8. Special course Research in Medical Microbiology was introduced, including<br />
lectures, seminars and laboratory experiments on <strong>the</strong> selected by students<br />
<strong>the</strong>mes. The very positive feedback was got from students. This course<br />
helps to select students able to proceed with PhD studies.<br />
5. <strong>Name</strong> <strong>the</strong> factors which most disturb teaching (excluding financial resources).<br />
1. The medical microbiology is closely related with pathology, however, pathology<br />
is taught only after <strong>the</strong> microbiology. That makes difficult to provide<br />
95
SECTION I: SELF-EVALUATION<br />
96<br />
students with <strong>the</strong> problem-based teaching and discussions <strong>of</strong> <strong>the</strong> cases <strong>of</strong><br />
individual patients.<br />
2. The elective courses have to be performed in late afternoon (up to 8.00<br />
p.m.) as <strong>the</strong> time- schedule <strong>of</strong> students is still very tight.<br />
3. The PhD students stipend and research money are extremely low in Tartu<br />
University, and thus, in future, <strong>the</strong>re may arise problems to get <strong>the</strong> gifted<br />
personelle for academic education.<br />
II. EVALUATION OF TEACHING<br />
1. The students are asked to give <strong>the</strong>ir suggestions for improvement <strong>of</strong> <strong>the</strong><br />
teaching. The evaluation seems to be different during <strong>the</strong> course and after<br />
final exam - in <strong>the</strong> latter case understand better <strong>the</strong> goals <strong>of</strong> teachers and<br />
<strong>the</strong>ir success.<br />
2. After every exam <strong>the</strong> students are asked to fill anonymously a questionnaire<br />
evaluating <strong>the</strong> teaching.<br />
3. Different lecturers are asked to participate on <strong>the</strong> lectures <strong>of</strong> <strong>the</strong> o<strong>the</strong>rs and<br />
make <strong>the</strong>ir kind remarks.<br />
4. Head <strong>of</strong> <strong>the</strong> <strong>Department</strong> discusses <strong>the</strong> lectures <strong>of</strong> <strong>the</strong> o<strong>the</strong>r associate pr<strong>of</strong>essors<br />
in order to keep similar standpoints.<br />
6. How is <strong>the</strong> quality <strong>of</strong> <strong>the</strong> teaching in your department evaluated? How are<br />
<strong>the</strong> content and <strong>the</strong> modes <strong>of</strong> <strong>the</strong> teaching changed on <strong>the</strong> basis <strong>of</strong> <strong>the</strong><br />
evaluation?<br />
1. The different chapters <strong>of</strong> Estonian textbooks always end with particular<br />
questions, looking on <strong>the</strong> provided material from some practical viewpoint.<br />
These questions are discussed on <strong>the</strong> seminars.<br />
2. The small 5-min tests during <strong>the</strong> lectures are applied to fix <strong>the</strong> knowledge<br />
<strong>of</strong> previous lecture.<br />
3. Every practical lab work ends with <strong>the</strong> control <strong>of</strong> <strong>the</strong> conclusive results,<br />
written by <strong>the</strong> student or discussing <strong>the</strong> self-assassment.<br />
4. After summarising <strong>the</strong> data <strong>of</strong> <strong>the</strong> student's questionnaire, <strong>the</strong> <strong>Department</strong><br />
always discusses <strong>the</strong> pros and contras, trying to change something pointed<br />
on<br />
5. The matters pointed in evaluation have been immediately used in <strong>the</strong> planning<br />
<strong>of</strong> <strong>the</strong> programme and performance <strong>of</strong> <strong>the</strong> next course.<br />
6. Research oriented elective course was reintroduced which has been very<br />
popular in 1995-1996.<br />
7. There are created <strong>the</strong> new labworks, covering better <strong>the</strong> most impotant issues<br />
<strong>of</strong> microbiological diagnostics.
III. PEDAGOGIC TRAINING OF STAFF<br />
MICROBIOLOGY<br />
7. How many <strong>of</strong> <strong>the</strong> teachers have received pedagogic training?<br />
Special pedagogic courses have not been attended by <strong>the</strong> staff. Yet, all pedagogic<br />
staff has received practical training for <strong>the</strong>ir teaching work. The staff has<br />
been working for a long time (more than 10 year in mean, range 5- 30 y). All<br />
teachers have got several educatory courses in USA, Sweden, Finland, Russia.<br />
In 1995, <strong>the</strong> pr<strong>of</strong>essor (MM) got a special training in <strong>the</strong> problem-biased<br />
medicine in Oslo University. Docent Reet Mändar passed <strong>the</strong> educational<br />
courses in Illinois University, USA, senior assistant Tatjana Brilene and Reet<br />
Mändar participated in Stockholm University microbial ecology course, docent<br />
Tõnis Karki received epidemiology training in Copenhagen.<br />
8. Is <strong>the</strong>re a need for fur<strong>the</strong>r pedagogic training?<br />
Seemingly, <strong>the</strong> special training how to provide more effective teaching, which<br />
problems should be discussed more or less in medical microbiology, how to<br />
use interactive methods, could be <strong>of</strong> some value for every person <strong>of</strong> <strong>the</strong> staff.<br />
IV. TEACHING RESOURCES<br />
9. Is <strong>the</strong>re a need for rearrangement <strong>of</strong> <strong>the</strong> teaching resources in your department?<br />
If so, how should this be done?<br />
In our department <strong>the</strong> research staff takes part in teaching process. So, we<br />
can provide several lectures on different <strong>the</strong>mes. We do not see any need for<br />
rearrangement <strong>of</strong> lectures/seminars<br />
Yet, more tight programs in lab courses seemingly <strong>of</strong>fer <strong>the</strong> possibility to rearrange<br />
some labworks for teaching practical problems <strong>of</strong> microbiology diagnostics.<br />
V. COORDINATION OF THE TEACHING<br />
10. How is <strong>the</strong> teaching co-ordinated with o<strong>the</strong>r departments? Indicate <strong>the</strong> departments<br />
that are closest to your department.<br />
• Infectious diseases,<br />
• Immunology,<br />
• Pathology<br />
• Internal medicine<br />
• The Immunology and pathology has evaluated <strong>the</strong> related materials <strong>of</strong> our<br />
textbook and got acquainted with <strong>the</strong> program.<br />
• The co-ordination <strong>of</strong> teaching with infectious diseases and internal medicine<br />
chair could be better.<br />
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SECTION I: SELF-EVALUATION<br />
VI. FUTURE PLANS<br />
11. Future plans to improve <strong>the</strong> teaching given by <strong>the</strong> department.<br />
Progess in scientific knowledge does not allow to stop <strong>the</strong> changes in medical<br />
microbiology curriculum. The newest data on possibilities <strong>of</strong> diagnostics and<br />
treatment <strong>of</strong> infectious diseases should be continuously brought to students.<br />
1. The molecular basis <strong>of</strong> infectious diseases and <strong>the</strong>ir diagnostic is improving<br />
day by day, demanding to keep also <strong>the</strong> medical curriculum fluent.<br />
2. We have started <strong>the</strong> refreshment courses for general practitioners. By this<br />
we hope to build a positive network between medical doctors, laboratory<br />
specialists and <strong>the</strong> university teachers. The aim will be to evaluate and develop<br />
<strong>the</strong> university education and skills according to <strong>the</strong> everyday practice<br />
and demands <strong>of</strong> research centres.<br />
98<br />
3. The new idea is to organise at <strong>the</strong> end <strong>of</strong> <strong>the</strong> semester before exams a<br />
conference on <strong>the</strong> achievements <strong>of</strong> students in labwork, research and present<br />
also <strong>the</strong> best referates.
MICROBIOLOGY<br />
Microbiology: resource evaluation<br />
1. Study materials<br />
- How many study books are published in your institution during last five years? 5<br />
- Do you have separate room as library in your place? Yes No<br />
- Could students borrow study books from your institution? Yes No<br />
- Do you have on-line published study materials for students? Yes No<br />
- WWW address: http://biomedicum.ut.ee/armb/<br />
- Does University library has enough modern books in your speciality?<br />
Completely enough Enough Scarcely Absolutely scarcely No<br />
2. Amount and size <strong>of</strong> study rooms<br />
- Rooms used by Your institution only: 1 rooms with area <strong>of</strong> 59.7 m 2<br />
- Rooms shared with ano<strong>the</strong>r institution: 1 rooms with area <strong>of</strong> 39.6 m 2<br />
- Do You have enough space for study process by Your opinion?<br />
Completely enough Enough Scarce Absolutely scarcely<br />
- How <strong>the</strong> scarce <strong>of</strong> space should be handled or changed?<br />
New building Change to smaller student groups Better logistics<br />
O<strong>the</strong>r way (describe shortly)<br />
3. Current situation <strong>of</strong> study rooms<br />
- There has been repairments in last - years (except Biomedicum)<br />
- How are <strong>the</strong> study rooms lightened?<br />
Very good Good Some darkness Absolutely dark for study<br />
- Evaluation <strong>of</strong> general conditions: Very good Good Satisfactory Bad<br />
4. Your institution has<br />
a) 1 (how many?) auditorium(s) for workshops/seminars with 22 places, equipped with<br />
Blackboard<br />
White board & markers<br />
Screen<br />
Overhead projector<br />
Data projector<br />
Slide projector<br />
b) 1 (how many?) laboratories for practicals with 24 places, equipped with<br />
Blackboard<br />
White board and markers<br />
Screen<br />
Overhead projector<br />
Data projector<br />
Slide projection kit<br />
TV/Video projection set<br />
Computer<br />
Internet connection<br />
TV/Video projection kit<br />
Computer<br />
Internet connection<br />
5. Working rooms for teaching staff and postgraduate students:<br />
- Number <strong>of</strong> teaching staff 11<br />
- Number <strong>of</strong> rooms for staff 8<br />
- Number <strong>of</strong> individual working places 11, among <strong>the</strong>m with computers 4<br />
- Number <strong>of</strong> postgraduate students is 7<br />
- How many individual working places <strong>the</strong>y have? 7<br />
- How many computers <strong>the</strong>y have? 3<br />
6. O<strong>the</strong>r comments on resource topic (max 250 letters):<br />
99
SECTION I: APPENDIXES<br />
APPENDIX I-I<br />
Visits <strong>of</strong> <strong>the</strong> <strong>Department</strong> members to o<strong>the</strong>r institutions abroad during 1996-2000<br />
Year Res/Lectures Institution Country Purpose Duration<br />
1996 Heidi Annuk, post-grad University <strong>of</strong> Lund Sweden Research 3 months<br />
1996 Tõnu Krispin, docent Swedish Institute <strong>of</strong> Infectious Disease<br />
Control<br />
100<br />
Sweden Research/training 1 week<br />
1996 Tõnis Karki, sr ass Statens Seruminstitut Denmark Training 2 weeks<br />
1997 Paul Naaber, res Karolinska Institut Sweden Training 1 week<br />
1997 Tõnu Krispin, docent Swedish Institute <strong>of</strong> Infectious Disease<br />
Control<br />
1998 Annika Krüüner, postgrad<br />
Swedish Institute <strong>of</strong> Infectious Disease<br />
Control<br />
Sweden Research/training 1 week<br />
Sweden Research 6 months<br />
1998 Marika Mikelsaar, pr<strong>of</strong> Karolinska Institut Sweden Lecture 1 week<br />
1998 Paul Naaber, res ESCMID, Madrid Spain Training 1 week<br />
1998 Tõnu Krispin, docent Swedish Institute <strong>of</strong> Infectious Disease<br />
Control<br />
1999 Annika Krüüner, postgrad<br />
Swedish Institute <strong>of</strong> Infectious Disease<br />
Control<br />
Sweden Research/training 1 week<br />
Sweden Research 6 months<br />
1999 Heidi Annuk, post-grad University <strong>of</strong> Lund Sweden Seminar/research 4 weeks<br />
1999 Heidi Annuk, post-grad University <strong>of</strong> Lund Sweden Research 5 weeks<br />
1999 Marika Mikelsaar, pr<strong>of</strong> University <strong>of</strong> Tübingen Germany Lecture/seminar 1 week<br />
1999 Siiri Kõljalg, res Swedish Institute <strong>of</strong> Infectious Disease<br />
Control<br />
2000 Annika Krüüner, postgrad<br />
2000 Annika Krüüner, postgrad<br />
Swedish Institute <strong>of</strong> Infectious Disease<br />
Control<br />
Sweden Research 1 week<br />
Sweden Research 4 months<br />
Int. course on <strong>the</strong> TB management Canada Seminar/training 2 weeks<br />
2000 Heidi Annuk, post-grad University <strong>of</strong> Lund Sweden Research 1 week<br />
2000 Heidi Annuk, post-grad Karolinska Institut Sweden Seminar 1 week<br />
2000 Reet Mändar, docent Karolinska Institut Sweden Seminar 1 week<br />
2000 Tatjana Brilene, sr ass Karolinska Institut Sweden Seminar 1 week<br />
2000 Tõnu Krispin, docent Swedish Institute <strong>of</strong> Infectious Disease<br />
Control<br />
APPENDIX I-II<br />
Sweden Research/training 1 week<br />
Postgraduate students at <strong>the</strong> <strong>Department</strong> having studied abroad during 1996-2000<br />
Year <strong>Name</strong> Institution Contry Duration<br />
1996 Paul Naaber Karolinska Institut Sweden 4 weeks<br />
1996 Siiri Kõljalg National Institut <strong>of</strong> Health Sweden 3 weeks<br />
1996 Heidi Annuk University <strong>of</strong> Lund Sweden 3 months<br />
1997 Siiri Kõljalg University <strong>of</strong> Lund Sweden 4 weeks<br />
1997 Paul Naaber Karolinska Institut Sweden 1 week<br />
1998 Heidi Annuk University <strong>of</strong> Lund Sweden 4 weeks<br />
1998 Annika Krüüner Swedish Institute <strong>of</strong> Infectious Disease Control Sweden 6 months<br />
1999 Annika Krüüner Swedish Institute <strong>of</strong> Infectious Disease Control Sweden 6 months<br />
1999 Heidi Annuk University <strong>of</strong> Lund Sweden 9 weeks<br />
2000 Annika Krüüner Ottawa Tuberculosis Research Centre Canada 2 weeks<br />
2000 Annika Krüüner Swedish Institute <strong>of</strong> Infectious Disease Control Sweden 4 months<br />
2000 Heidi Annuk University <strong>of</strong> Lund Sweden 1 week<br />
2000 Heidi Annuk Karolinska Institut Sweden 1 week
APPENDIX I-III<br />
MICROBIOLOGY<br />
Co-operation with institutions from o<strong>the</strong>r countries and participation in international<br />
research projects during 1996-2000<br />
Contact person Institution Country Aim <strong>of</strong> <strong>the</strong> collaboration<br />
Pr<strong>of</strong>. Marika Mikelsaar Karolinska Institut Sweden Research<br />
Pr<strong>of</strong>. Marika Mikelsaar Karolinska Institut Sweden Research, advanced molecular<br />
technics in microbiology<br />
Pr<strong>of</strong>. Marika Mikelsaar University <strong>of</strong> Lund Sweden Research<br />
Pr<strong>of</strong>. Marika Mikelsaar, Swedish Institute <strong>of</strong> Infectious Sweden AB resistance<br />
Res. Siiri Kõljalg Disease Control<br />
Postgrad. Annika Krüüner University <strong>of</strong> Kuopio Finland Research, advanced technics in high<br />
pressure liquid chromatography<br />
Doc. Tõnis Karki WHO/Harvard University Switzerland/USA AB resistance surveillance<br />
APPENDIX I-IV<br />
Visiting lecturers at <strong>the</strong> <strong>Department</strong> during 1996-2000<br />
Visitor Institution Country Purpose <strong>of</strong> <strong>the</strong> Visit<br />
Pr<strong>of</strong>. Bengt Björksten University <strong>of</strong> Linköping Sweden Research<br />
Pr<strong>of</strong>. Torkel Wadström University <strong>of</strong> Lund Sweden Research<br />
Pr<strong>of</strong>. Aimo Salmi University <strong>of</strong> Turku Finland Research<br />
Pr<strong>of</strong>. Sven H<strong>of</strong>fner Institute <strong>of</strong> Infectious Disease Control Sweden Research<br />
APPENDIX I-V<br />
Scientific journals available at <strong>the</strong> <strong>Department</strong><br />
No <strong>Name</strong> <strong>of</strong> Journal Version<br />
1. Antimicrobial Agents and Chemo<strong>the</strong>rapy paper<br />
2. ASM News paper<br />
3. Clinical Microbiology and Infection paper<br />
4. Clinical Microbiology Reviews paper<br />
5. Emerging Infectious Diseases paper<br />
6. Journal <strong>of</strong> Clinical Microbiology paper<br />
7. Microbial Ecology in Health and Disease paper<br />
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SECTION I: APPENDIXES<br />
APPENDIX I-VI<br />
Publications <strong>of</strong> <strong>the</strong> <strong>Department</strong> members during 1996-2000<br />
MONOGRAPHIES<br />
1. Mikelsaar, M., Mändar, R., Sepp, E.. Lactic acid micr<strong>of</strong>lora in <strong>the</strong> human microbial ecosystem and<br />
its development. In: Lactic Acid Bacteria, Marcel Dekker, Inc., New York, USA, 1998, 279-342.<br />
ISBN 0-8247-0133-X<br />
2. Mikelsaar M. Evaluation <strong>of</strong> <strong>the</strong> gastrointestinal microbial ecosystem in health and disease. Dissertationes<br />
Medicinae Universitatis Tartuensis. Tartu, 1992.<br />
3. Karki T. Quantitative composition <strong>of</strong> <strong>the</strong> human lact<strong>of</strong>lora and method for its examination.<br />
Dissertationes Medicinae Universitatis Tartuensis. Tartu, 1996.<br />
4. Mändar R. Vaginal micr<strong>of</strong>lora during pregnancy and its transmission to newborn. Dissertationes<br />
Medicinae Universitatis Tartuensis. Tartu, 1996.<br />
5. Naaber P. Clostridium difficile infection and intestinal microbial ecology. Dissertationes Medicinae<br />
Universitatis Tartuensis. Tartu, 1997.<br />
6. Sepp E. Formation <strong>of</strong> intestinal microbial ecosystem in children. Dissertationes Medicinae<br />
Universitatis Tartuensis. Tartu, 1998.<br />
7. Kõljalg S. Acinetobacter - an important nosocomial pathogen. Dissertationes Medicinae<br />
Universitatis Tartuensis. Tartu, 1999.<br />
8. Smidt I. In vitro and in vivo interaction <strong>of</strong> intestinal indigenous lactobacilli and opportunistic<br />
pathogens Clostridium difficile and Escherichia coli. Dissertation <strong>of</strong> Master's Degree. Tartu, 1999<br />
9. Lõivukene K. Antibiotic susceptibility <strong>of</strong> Helicobacter pylori strains and it's relations with vacA and<br />
cagA genotype in patients with gastritis and peptic ulcer. Dissertation <strong>of</strong> Master's Degree. Tartu,<br />
2000.<br />
PAPERS IN INTERNATIONAL JOURNALS<br />
1. Mikelsaar M., Mändar R., Maaroos H.-I., Päär S., Rägo T., Kisand K., Aleljung P., Wadström T.<br />
Helicobacter pylori gastritis in children: clinical, bacteriological, and morphological study. -<br />
Microecology and Therapy, 1996, 22, 44-53<br />
2. Mändar R., Mikelsaar M. Transmission <strong>of</strong> mo<strong>the</strong>r's micr<strong>of</strong>lora to <strong>the</strong> newborn at birth. - Biology <strong>of</strong><br />
<strong>the</strong> Neonate, 1996, 69, 30-35<br />
3. Mändar R., Mikelsaar M. Vaginal micr<strong>of</strong>lora during pregnancy. - Alpe Adria Microbiology Journal,<br />
1996, 5, 1, 41-50<br />
4. Naaber P., Lehto E., Salminen S., Mikelsaar M. Inhibition <strong>of</strong> adhesion <strong>of</strong> Clostridium difficile to<br />
Caco-2 cells. - FEMS Immunology and Medical Microbiology, 1996, 14, 205-209.<br />
5. Kõljalg S., Vuopio-Varkila J., Mikelsaar M., Wadström T. Cell surface properties <strong>of</strong> Acinetobacter<br />
baumannii. - APMIS, 1996, 104, 659-665.<br />
6. Naaber P, Klaus K, Sepp E, Björksten B, Mikelsaar M. Colonization <strong>of</strong> infants and hospitalized<br />
patients with Clostridium difficile and lactobacilli. Clinical Infectious Diseases 1997, 25, Suppl 2,<br />
189-190.<br />
7. Sepp E., Julge K., Vasar M., Naaber P., Björksten B., Mikelsaar M. Intestinal micr<strong>of</strong>lora <strong>of</strong> Estonian<br />
and Swedish infants. Acta Paediatrica, 1997, 86, 956-961.<br />
8. Türi M, Türi E, Kõljalg S, Mikelsaar M. Influence <strong>of</strong> aqueous extracts <strong>of</strong> medicinal plants on surface<br />
hyrophobicity <strong>of</strong> Escherichia coli strains <strong>of</strong> different origin. APMIS, 1997, 105, 956-962.<br />
9. Naaber P., Maimets M., Mikelsaar M. Prevalence and properties <strong>of</strong> Clostridium difficile in<br />
hospitalized patients <strong>of</strong> Estonia. - Reviews in Medical Microbiology, Chapman & Hall, 1997, 8,<br />
Suppl 1, 60-61.<br />
10. Oona M, Rägo T, Maaroos H-I, Mikelsaar M, Lõivukene K, Salminen S, Korhonen H. Helicobacter<br />
pylori in children with abdominal complaints: has immune bovine colostrum some influence on<br />
gastritis? Alpe Adria Microbiology Journal, 1997, 6, 49-57.<br />
11. Ormisson A, Sepp E, Siigur U, Varendi H, Mikelsaar M. Impact <strong>of</strong> early life nutrition on growth and<br />
intestinal micr<strong>of</strong>lora composition in low-birth-weight infants. Scand. J. Nutrition, 1997, 41, 71-74.<br />
12. Kaila, M., Isolauri, E., Sepp, E., Mikelsaar, M., Salminen, S. Fecal recovery <strong>of</strong> a human<br />
Lactobacillus strain (ATCC 53103) during dietary <strong>the</strong>rapy <strong>of</strong> rotavirus diarrhea in infants. -<br />
Bioscience Micr<strong>of</strong>lora, 1998, 17, 2, 149-151<br />
13. Krüüner, A., Sillastu, H., Danilovitsch, M., Levina, K., Svenson, S.B., Källenius, G., H<strong>of</strong>fner, S.E..<br />
Drug resistant tuberculosis in Estonia. - The Official Journal <strong>of</strong> <strong>the</strong> International Union Against<br />
Tuberculosis and Lung Disease "Tubercle and Lung Disease", 1998, 2, 2, 130-133.<br />
102
MICROBIOLOGY<br />
14. Mäkinen, K.K., Olak, J., Russak, S., Saag, M., Seedre, T., Vasar, R., Vihalemm, T., Mikelsaar, M.,<br />
Mäkinen, P.-L.. Polyol-combinant saliva stimulants: a 4-month pilot study in young adults. - Acta<br />
Odontologica Scandinavia, 1998, 56, 1-5.<br />
15. Naaber, P., Mikelsaar, R.-H., Salminen, S., Mikelsaar, M.. Bacterial translocation, intestinal<br />
micr<strong>of</strong>lora and morphological changes <strong>of</strong> intestinal mucosa in experimental models <strong>of</strong> Clostridium<br />
difficile infection. - Journal <strong>of</strong> Medical Microbiology, 1998, 47, 591-598.<br />
16. Lenzner, A. Vulvovaginalkandidose und Laktobazillen. - Med-Report, 1998, 25, 5.<br />
17. Lenzner, A., Lenzner, H., Karki, T. Lakt<strong>of</strong>lora vlagalistsa I perspektivõ sozdanija probiotikov iz<br />
laktobatsill dlja pr<strong>of</strong>ilaktiki I letsenija vulvovaginalnogo kandidoza. - Zurnal Akuserstva I Zenskih<br />
Boleznei, 1998, spets. võpusk, 85-86.<br />
18. Kõljalg, S., Sults, I., Raukas, E., Truu, J., Ustav, M., Mikelsaar, M. Distribution <strong>of</strong> Acinetobacter<br />
baumannii in a neurointensive care unit. - Scand. J. Infect. Dis., 1999, 31, 145-150.<br />
19. Björksten, B. Naaber, P., Sepp, E., Mikelsaar, M. The intestinal micr<strong>of</strong>lora in allergic Estonian and<br />
Swedish 2-year-old children. - Clin. Exp. Allergy, 1999, 29, 342-346.<br />
20. Annuk, H., Hirmo, S. Türi, E., Mikelsaar, M., Arak, E., Wadström, T. Effect on cell surface<br />
hydrophobicity and susceptibility <strong>of</strong> Helicobacter pylori to medicinal plant extracts - . FEMS<br />
Microbiology Letters, 1999, 172, 41-45.<br />
21. Türi, E., Türi, M., Annuk, H., Arak, E. Action <strong>of</strong> aqueous extracts <strong>of</strong> bearberry and cowberry leaves<br />
and wild camomille and pineapple-weed flowers on Escherichia coli surface structures. - Pharmac.<br />
Biol., 1999, 37, 2, 127-133.<br />
22. Mikelsaar, M. Türi, E., Türi, M., Smidt, I., Annuk, H., Mikelsaar, R.-H. Interaction <strong>of</strong> Lactobacillus<br />
fermentum and Escherichia coli in guinea pig testes model. - Micr. Ecol. Health and Disease, 1999,<br />
11, 2, 114.<br />
23. Annuk, H., Vainumäe, I., Aimla, K., Ausmees, K., Mikelsaar, M. Antagonistic activity <strong>of</strong> lactobacilli<br />
against urinary Escherichia coli. - Micr. Ecol. Health and Disease, 1999, 11, 2, 117.<br />
24. Lõivukene, K., Kolk, H., Mikelsaar, M., Kasenõmm, P., Ustav, M., Maaroos, H.-I. Comparison <strong>of</strong><br />
metronidazole susceptibility and vacA subtypes <strong>of</strong> H. pylori strains in patients with gastritis and<br />
peptic ulcer. - Gut, 1999, 45, A14.<br />
25. Mikelsaar, M., Sepp, E., Julge, K., Vasar, M., Duchen, K., Björksten , B. The micr<strong>of</strong>lora <strong>of</strong> <strong>the</strong><br />
intestinal tract as a reservoir for microbial translocation - is it similar in young children <strong>of</strong> Sweden<br />
and Estonia? - Clin. Micr. Infect., 1999, 5, 3, 272.<br />
26. Kõljalg, S., Naaber, P., Sepp, E., Mikelsaar, M. Changes in prevalence and resistance <strong>of</strong><br />
Acinetobacter spp. in a neurologic intensive care unit. Clin. Micr. Infect., 1999, 5, 3, 369.<br />
27. Lõivukene, K., Kolk, H., Maaroos, H.-I., Mikelsaar, M. Clarithromycin susceptibility <strong>of</strong> H .pylori<br />
strains in Estonia. - Clin. Micr. Infect., 1999, 5, 3, 258.<br />
28. Naaber, P., Kõljalg, S., Mikelsaar, M., Maimets, M. Antibiotic pressure and resistance pattern <strong>of</strong><br />
prevailing bacteria in Tartu University Clinics. - Clin. Micr. Infect., 1999, 5, 3, 239.<br />
29. Zusinaite, E., Salupere, R., Raukas, E., Ott, K., Kiiver, K., Ustina, V., Schmidt, J., Sizemski, L.,<br />
Krispin, T., Ustav, M. Hepatitis C virus genotypes in Estonia. – Acta Microbiol. Immunol. Hungarica,<br />
1999, 46, 4, 474-475.<br />
30. Mikelsaar M., Türi E., Türi M., Smidt I., Tamm., Mikelsaar R.-H. Interaction <strong>of</strong> Lactobacillus fermentum<br />
and Escherichia coli in guinea pig testes model. Micr. Ecol. Therapy, 1999, 28, 319-326.<br />
31. Annuk H., Vainumäe I., Aimla K., Ausmees K., Kullisaar T., Kask S., Mikelsaar M. Antagonistic<br />
activity <strong>of</strong> lactobacilli against urinary Escherichia coli. Microecol. Therapy, 1999, 28, 169-175.<br />
32. Naaber P., Smidt I., Tamme K., Liigant A., Tapfer H., Mikelsaar M., Talvik R. Translocation <strong>of</strong><br />
indigenous micr<strong>of</strong>lora in an experimental model <strong>of</strong> sepsis. J. Med. Microbiol., 2000, 49, 431-439.<br />
33. Lõivukene K., Kolk H., Maaroos H.-I., Kasenõmm P., Aro H., Ustav M., Mikelsaar M. Metronidazole<br />
and clarithromycin susceptibility and <strong>the</strong> subtypes <strong>of</strong> vacA <strong>of</strong> Helicobacter pylori isolates in Estonia.<br />
Scand. J. Infect. Dis., 2000, 32, 59-62.<br />
34. Sepp E., Naaber P., Voor T., Mikelsaar M., Björksten B. Development <strong>of</strong> intestinal micr<strong>of</strong>lora during<br />
<strong>the</strong> first month <strong>of</strong> life in Estonian and Swedish infants. Micr. Ecol. Health Dis., 2000, 12, 22-26.<br />
35. Vorobjova T., Faller G., Maaroos H.-I., Sipponen P., Villako K., Uibo R., Kirchner T. Significant<br />
increase in antigastric autoantibodies in a long-term follow-up study <strong>of</strong> H. pylori gastritis. Virchows<br />
Arch., 2000, 437, 1, 37-45.<br />
36. Vorobjova T., Grunberg H., Oona M., Maaroos H.-I., Nilsson I., Wadström T., Covacci A, Uibo R.<br />
Seropositivity to Helicobacter pylori and cagA protein in schoolchildren <strong>of</strong> different ages living in<br />
urban and rural areas in Sou<strong>the</strong>rn Estonia. Eur. J. Gastroenterol. Hepatol., 2000, 12, 1, 97-101.<br />
PAPERS IN ESTONIAN JOURNALS<br />
1. Kõljalg S., Kermes K., Lõivukene K., Naaber P., Mikelsaar M. Kirurgilisi infektsioone tekitavad<br />
mikroorganismid ja nende antibiootikumitundlikkus. - Eesti Arst, 1996, lisa, 39-40.<br />
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SECTION I: APPENDIXES<br />
2. Mikelsaar M. Hospitaalinfektsioon tänapäeval. - Eesti Arst. Tallinn, 1996, 3, 237-245.<br />
3. Sõritsa A., Levkov L., Ott P. Doonor-inseminatsiooni efektiivsus lastetuse ravis. - Eesti Arst, 1996,<br />
lisa, 82-83.<br />
4. Karki T., Lenzner H., Lenzner A. Lactobacillus casei toime seedekulgla lakt<strong>of</strong>loorasse. - Eesti Arst,<br />
1996, 1, 30-34.<br />
5. Karki T., Lenzner H., Lenzner A. Laktobatsillide ja Saccharomyces boulardii manustamise toime<br />
seedekulgla lakt<strong>of</strong>loorasse. - Eesti Arst, 1996, lisa, 26-27.<br />
6. Koslov N., Krüüner A., Türi M., Türi E. Mükobakterioosi esinemise ja leviku võimalused Eestis. -<br />
Eesti Arst, 1996, lisa, 34-35.<br />
7. Krüüner A., H<strong>of</strong>fner S., Juhani A., Türi E. Multiresistentsete Mycobacterium tuberculosis'e tüvede<br />
esinemine ja levik Eestis. - Eesti Arst, 1996, lisa, 35-36.<br />
8. Naaber P. Ülevaade kongressist "Anaeroobsed mikroobid ja nende poolt põhjustatud infektsioonid,<br />
Chicago, 19-21 juuli 1996". - Eesti Arst, 1996, 6, 545-546.<br />
9. Türi M., Annuk H., Laanes K., Lepiku M., Arak E., Türi E. Eestis enamkasutatavate ravimtaimede<br />
toime Escherichia coli pinnastruktuuride aktiivsusesse. - Eesti Arst, 1996, lisa, 88-89.<br />
10. Kolk H., Maaroos H.-I., Lõivukene K., Mikelsaar M., Lindberg G. 13 C-uurea hingamistesti<br />
rakendamine Helicobacter pylori infektsiooni diagnoosimiseks. Eesti Arst, 1996, lisa, 31.<br />
11. Annuk H., Raukas M., Türi E., Türi M., Arak E. Leesikalehtede (Uvae ursi folium) vesitõmmiste<br />
toime Escherichia coli agregatiivsele aktiivsusele I. - Eesti Rohuteadlane, Tartu , 1997, 3, 3-5.<br />
12. Annuk H., Raukas M., Türi E., Türi M., Arak E. Leesikalehtede (Uvae ursi folium) vesitõmmiste<br />
toime Escherichia coli agregatiivsele aktiivsusele II. Eesti Rohuteadlane, 1997, 4, 3-5.<br />
13. Sepp E., Lõivukene K., Naaber P., Kermes K., Julge K., Vasar M., Björksten B., Mikelsaar M.<br />
Tervete ja allergiliste laste mikr<strong>of</strong>loora erinevused. Eesti Rohuteadlane, 1997, lisa, 62-63.<br />
14. Sepp E., Metsvaht T. Vastsündinute bakterieemiate struktuur ja laboratoorne diagnoosimine Tartu<br />
Lastekliiniku intensiivraviosakonna andmeil.Eesti Arst, 1997, 6, 513-519.<br />
15. Sõritsa A., Levkov L., Ott P. Esimene sünnitus Eestis munarakudoonorluse tulemusena. - Eesti<br />
Arst, 1997, 1, 22-25.<br />
16. Brilene T., Põder A., Raukas E., Vindirevskih G., Uusküla A. Chlamydia trachomatis'e<br />
infektsioonide diagnoos sümptomaatilise tupevoolusega naispatsientidel. - Eesti Rohuteadlane,<br />
Tartu , 1997, lisa, 8-9.<br />
17. Karki T., Vares P., Kõljalg S., Kirm A. Elektrokeemiliselt töödeldud vesilahuste bakteritsiidsest<br />
toimest in vitro. - Eesti Rohuteadlane, Tartu , 1997, lisa, 15-17.<br />
18. Krüüner A., Danilovits M., Türi E. Ravimiresistentsete Mycobacterium tuberculosis'e tüvede<br />
osatähtsusest tuberkuloosi etioloogias Eestis. - Eesti Rohuteadlane, Tartu , 1997, lisa, 23-24.<br />
19. Kõljalg S., Sults I., Raukas E., Mikelsaar M. Acinetobacter baumannii persisteerimine<br />
neurointensiivravi osakonnas. - Eesti Rohuteadlane, Tartu, 1997, lisa, 26-27.<br />
20. Mikelsaar M., Karki T., Kirsberg E., Kõljalg S., Kermes K., Mägi H., Ivanova M., Rauk S., Timmas<br />
T., Jõks U. Uroinfektsioonidega Eesti patsientide Escherichia coli tüvede tundlikkus antibiootikumidele.<br />
- Eesti Rohuteadlane, Tartu , 1997, lisa, 35-36.<br />
21. Mändar R., Lõivukene K., Türi M., Mikelsaar M. Eesti ja Rootsi lastelt isoleeritud laktobatsillitüvede<br />
tundlikkus antibiootikumide suhtes. - Eesti Rohuteadlane, Tartu, 1997, lisa, 37-38.<br />
22. Raukas E., Krispin T., Ott K., Sizemski L. Polümeraasi ahelreaktsioon Eestis isoleeritud B-hepatiidi<br />
viirustüvedega: kvalitatiivsed ja kvantitatiivsed aspektid. - Eesti Rohuteadlane. Tartu , 1997, lisa,<br />
52-54.<br />
23. Kõljalg S. Esmane hospitaalinfektsiooni kontrolli kogemus. - Eesti Arst, Tallinn , 1997, 1, 57-64.<br />
24. Raukas, E., Krispin, T., Ott, K., Sizemski, L., Ustav, M. Polümeraasi ahelreaktsioon Eestis<br />
isoleeritud B-hepatiidiviiruse tüvedega. Tingimuste optimeerimine ja kasutamise võimalused. -<br />
Eesti Arst, 1998, 3, 210-214.<br />
25. Lenzner, A. Friedrich Robert Faehlmann arstina ja arstiteadlasena. - Akadeemia, 1998, 12, 2471-<br />
2476.<br />
26. Karki, T. Lihasööja bakter. - Tervis, 1998, 10, 66.<br />
27. Karki, T. Toksoplasmoos. - Tervis, 1998, 10, 66.<br />
28. Karki, T. Võidujooks antibiootikumresistentsusega. - Hippokrates, 1998, 1, 37-41.<br />
29. Lenzner, A. Kogumik "Nakkus- ja parasiithaigused Eestis (statistikaandmed)". - Eesti Arst, 1999, 2,<br />
157.<br />
30. Lenzner, A Selma Laanes 85. - Universitas Tartuensis, 1999, 27.08.1999.<br />
31. Mikelsaar, M. Tartu Ülikooli mikrobioloogia instituut 70-aastane. - Eesti Arstide Liidu Teataja, 1999,<br />
12, 15-16.<br />
32. Songisepp E., Mikelsaar M. Rukkileiva juuretise kvaliteeti kindlustavad leivajuuretise<br />
piimhappebakterid. Põllumajandus, 2000, 4,5, 5-7.<br />
33. Lõivukene K., Kolk H., Maaroos H.-I., Mikelsaar M. Helicobacter pylori tüvede metronidasool- ja<br />
klaritromütsiintundlikkus Eesti patsientide seas. Eesti Arst, 2000, 8, 453-459.<br />
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MICROBIOLOGY<br />
34. Kõljalg S., Karki T., Olsson-Liljequist B. Metsitsilliin-resistentse Staphylococcus aureus'e esinemissagedus<br />
Eestis. Eesti Arst, 2000, 8, 466-470.<br />
35. Mikelsaar M. Esilekerkivad infektsioonid. Eesti Arst, 2000, 8, 471-480.<br />
36. Kasenõmm, P. Krooniline retsidiveeruv tonsilliit. Eesti Arst, 2000, 8, 481-485.<br />
37. Mändar R. Antibakteriaalsete preparaatide mõju normaalsele mikr<strong>of</strong>loorale. Eesti Arst, 2000, 8,<br />
486-491.<br />
38. Karki T. Antibiootikumid ja antibiootikumresistentsus. Eesti Arst, 2000, 8, 492-498.<br />
SUBMITTED PAPERS<br />
1. Mändar R., Lõivukene K., Ehrenberg A., Smidt I., Raukas E., Kask V., Mikelsaar M. Amniotic fluid<br />
micr<strong>of</strong>lora in asymptomatic women at mid-gestation. Scand. J. Infect. Dis., 2000, 32 (in press).<br />
2. Naaber P., Kõljalg S., Maimets M. Antibiotic usage and resistance - trends in Estonian University<br />
Hospitals. Intern. J. Antimicr. Agents, 2000 (in press).<br />
3. Mändar R., Lõivukene K., Hütt P., Karki T., Mikelsaar M. Antibacterial susceptibility <strong>of</strong> intestinal<br />
lactobacilli <strong>of</strong> healthy children. Scand. J. Infect. Dis. (accepted).<br />
4. Sillakivi T., Aro H., Peetsalu M., Peetsalu A., Mikelsaar M. Geographic and ethnic differences in<br />
genotypes <strong>of</strong> Helicobacter pylori among Estonian and Russian patients with perforated peptic ulcer,<br />
living in Sou<strong>the</strong>rn Estonia. Clin. Micr. Infect. (accepted)<br />
5. Karki T., Truusalu K., Vainumäe I., Mikelsaar M. Antibiotic susceptibility patterns <strong>of</strong> community and<br />
hospital acquired Staphylococcus aureus and Escherichia coli in Estonia. Scand. J. Infect. Dis.<br />
(accepted)<br />
6. Krüüner A., H<strong>of</strong>fner S.E., Sillastu H., Danilovits M., Levina K., Svenson S.B., Ghebremichael S.,<br />
Källenius G. Spread <strong>of</strong> drug resistant pulmonary tuberculosis in Estonia. J. Clin. Microbiol.<br />
(submitted)<br />
7. Mikelsaar M., Annuk H., Stsepetova J., Kullisaar T., Zilmer M, Björksten B. Intestinal lact<strong>of</strong>lora <strong>of</strong><br />
Estonian and Swedish children. Micr. Ecol. Health Dis. (submitted)<br />
8. Kullisaar T., Zilmer T., Mikelsaar M., Vihalem T., Annuk H., Kairane C., Kilk A. Two antioxidative<br />
Lactobacillus fermentum strains as promising probiotics. Int. J. Food Microbiol. (submitted)<br />
9. Naaber P., Tamm E., Kõljalg S., Pütsepp A., Maimets M. Nasopharyngeal carriage and<br />
antibacterial susceptibility <strong>of</strong> Streptococcus pneumoniae, haemophilus influenzae, and Moraxella<br />
catarrhalis in Estonian children. Clin. Micr. Infect. (submitted)<br />
10. Olsson-Liljequist B., Kõljalg S., Karlsson I., Kronvall G. Calibration <strong>of</strong> fusidic acid disk diffusion<br />
susceptibility testing <strong>of</strong> Staphylococcus aureus in two countries using different standards. J.<br />
Antimicr. Chemo<strong>the</strong>r. (submitted)<br />
TEXTBOOKS AND MANUALS<br />
1. Karki T., Brilene T., Mikelsaar M. Meditsiinilise mikrobioloogia praktikum I osa. - Tartu: TÜ<br />
Kirjastus, 1997. - 112 lk.<br />
2. Karki T., Krispin T., Mändar R., Mikelsaar M. Meditsiinilise mikrobioloogia praktikum II osa. - Tartu:<br />
TÜ Kirjastus, 1997. - 116 lk.<br />
3. Mikelsaar, M., Mändar, R. Kliinilise mikrobioloogia käsiraamat. - Tallinn, AS Medicina, 1998. - 363<br />
lk. ISBN 9985-829-16-6<br />
4. Kask, V., Mändar, R. Tupe mikr<strong>of</strong>loora ja selle patoloogilised seisundid. - Tartu, OÜ Tartumaa<br />
Trükikoda, 1997. - 39 lk.<br />
5. Mikelsaar, M., Karki, T. Meditsiiniline mikrobioloogia I osa. - Tartu, Tartu Ülikooli Kirjastus, 1998. -<br />
244 lk. ISBN 9985-4-0047-X<br />
6. Karki, T., Brilene, T., Mikelsaar, M. Praktilised tööd mikrobioloogias I osa. - Tartu, Tartu Ülikooli<br />
Kirjastus, 1998. - 149 lk.<br />
7. Karki, T. Krispin, T., Mändar, R., Mikelsaar, M. Praktilised tööd mikrobioloogias II osa. - Tartu,<br />
Tartu ülikooli Kirjastus, 1999. - 117 lk.<br />
8. Mikelsaar, M. Meditsiin ja mikrobioloogia uuel aastatuhandel. Tartu, Tartu Ülikooli Kirjastus, 1999.<br />
– 42 lk.<br />
9. Tartu Ülikooli mikrobioloogia instituut 70. – Toimetaja M. Mikelsaar. Tartu, Tartu Ülikooli Kirjastus,<br />
1999. – 35 lk.<br />
10. Mikelsaar, M., Karki, T. Meditsiiniline mikrobioloogia II osa. - Tartu, Tartu Ülikooli Kirjastus, 2000. -<br />
256 lk. ISBN 9985-4-0132-8<br />
105
APPENDIX I-VII<br />
Academic and administrative personnel: <strong>Department</strong> <strong>of</strong> Microbiology<br />
MICROBIOLOGY<br />
<strong>Name</strong> Title Load Area Gender Birth year Scinetific degree Year <strong>of</strong> commencement Labour time (y)<br />
1. Marika Mikelsaar Pr<strong>of</strong>essor 1,00 Medical microbiology Female 1938 Cand.Sci & Dr.Med 1969 & 1990 38<br />
2. Akivo Lenzner Pr<strong>of</strong>. emeritus 1,00 Medical microbiology Male 1927 Dr.Sci. 1973 38<br />
3. Tõnu Krispin Docent 1,00 Medical microbiology Male 1939 Dr.Sci. 1990 9<br />
4. Tatjana Brilene Docent 1,00 Medical microbiology Female 1955 Cand.Sci 1990 21<br />
5. Tõnis Karki Docent 1,00 Medical microbiology Male 1963 Dr.Med 1996 12<br />
6. Reet Mändar Docent 1,00 Medical microbiology Female 1964 Dr.Med 1996 12<br />
7. Siiri Kõljalg Researcher 0,50 Medical microbiology Female 1964 Dr.Med 1999 8<br />
8. Epp Sepp Sr. Researcher 0,50 Medical microbiology Female 1963 Dr.Med 1998 7<br />
9. Paul Naaber Sr. Researcher 0,50 Medical microbiology Male 1966 Dr.Med 1997 4<br />
10. Eha Kirsberg Sr. Technical staff 1,00 Medical microbiology Female 1957 20<br />
11. Silvi Truus Technical staff 1,00 Medical microbiology Female 1936 35<br />
12. Reet Raag Technical staff 1,00 Medical microbiology Female 1944 22<br />
13. Irina Bubnova Technical staff 1,00 Medical microbiology Female 1952 3<br />
14. Irja Roots Secretary 1,00 Medical microbiology Female 1959 21<br />
1 Dr.Sci and Cand.Sci are degrees <strong>of</strong> <strong>the</strong> Former Soviet Union which correspond to a Dr.Med and Ph.D, respectively<br />
107
APPENDIX I-VIII<br />
Curriculum Vitae <strong>of</strong> <strong>the</strong> staff<br />
MICROBIOLOGY<br />
MIKELSAAR, MARIKA 2. Date <strong>of</strong> birth: 12.11.1936 3. Gender: female 4. Citizenship: Estonian 5. Address:<br />
Jakobsoni 11-4 Tartu, Estonia 6. Educational history: University <strong>of</strong> Tartu, Medical Faculty,<br />
M.D. 1963. 7. Academic degrees: Ph.D. Tartu University, 1969 - "Lactobacilli in faecal ecosystem in<br />
different gastrointestinal diseases <strong>of</strong> non-infectious origin". Doctor <strong>of</strong> medical sciences, Tartu University,<br />
1992 - " Evaluation <strong>of</strong> <strong>the</strong> gastrointestinal microbial ecosystem in health and disease". 8. Employment<br />
and pr<strong>of</strong>essional experience: 1963-1965 resident at <strong>Department</strong> <strong>of</strong> Microbiology, University<br />
<strong>of</strong> Tartu. 1965-1969 post-graduated student in <strong>Department</strong> <strong>of</strong> Microbiology, University <strong>of</strong> Tartu.<br />
From 1969 to 1979 worked as junior research associate at <strong>the</strong> Laboratory <strong>of</strong> Microbial Ecology <strong>of</strong> <strong>the</strong><br />
Institute <strong>of</strong> General and Molecular Pathology (IGMP) <strong>of</strong> Tartu University, from 1979 to 1990 - as a<br />
senior research associate. In 1991 she became <strong>the</strong> head <strong>of</strong> Microbiology Laboratory <strong>of</strong> Tartu University<br />
Hospital and a senior research associate at <strong>the</strong> clinical bacteriology group <strong>of</strong> <strong>the</strong> IGMP, Tartu University.<br />
In April, 1993 was elected for Pr<strong>of</strong>essor <strong>of</strong> Microbiology by <strong>the</strong> council <strong>of</strong> Tartu University and<br />
pointed as <strong>the</strong> head <strong>of</strong> department. 9. Administrative experience: 1991-1993 Head <strong>of</strong> Laboratory <strong>of</strong><br />
Microbiology <strong>of</strong> Tartu University Hospital; 1993- Head <strong>of</strong> <strong>Department</strong> <strong>of</strong> Microbiology <strong>of</strong> University <strong>of</strong><br />
Tartu 10. Honours/awards: National Scientific Award in medicine for 1994; award <strong>of</strong> Faculty <strong>of</strong> Medicine<br />
<strong>of</strong> Tartu University 1997. 11. Membership in academic and scientific societies: Society <strong>of</strong> Estonian<br />
Medical Microbiologists - member <strong>of</strong> council; SOMED - member; American Society <strong>of</strong> Microbiology<br />
- member; Alpe Adria EMBASE Journal - member <strong>of</strong> editional board; Regular referee <strong>of</strong> journal<br />
Microbial Ecology in Health and Disease 12. Current research program and grants: medical microbiology,<br />
antibiotic resistance, microbial ecology Investigation <strong>of</strong> pathogenesis and new methods <strong>of</strong><br />
prophylaxis and treatment <strong>of</strong> most important infectious diseases in Estonia; Development <strong>of</strong> principles<br />
for microbiological surveillance <strong>of</strong> hospital infections, antibiotic and biocide resistance and strating <strong>the</strong><br />
reference laboratory; Development <strong>of</strong> intestinal micr<strong>of</strong>lora in newborns in relation to environmental<br />
factors; Allergy related to environmental factors: intestinal micr<strong>of</strong>lora; Baltic Project: antibiotic resistance<br />
in Estonia. 13. Supervision <strong>of</strong> dissertations: Epp Sepp - master <strong>of</strong> sciences, biomedicine<br />
1994; Reet Mändar - doctor <strong>of</strong> medicine 1996; Paul Naaber - doctor <strong>of</strong> medicine 1997; Epp Sepp -<br />
doctor <strong>of</strong> medicine 1998; Siiri Kõljalg - doctor <strong>of</strong> medicine 1999; Imbi Smidt - master <strong>of</strong> sciences, biomedicine<br />
1999; Krista Lõivukene - master <strong>of</strong> sciences, biomedicine 2000. Now supervising <strong>the</strong> doctorate<br />
<strong>the</strong>sis program <strong>of</strong> 5 doctorates and 2 M.Sci. 14. Publications: 284 publications, incl. 5 books (2<br />
international) and 71 international papers<br />
KÕLJALG, SIIRI Date <strong>of</strong> birth1964-06-30, Viljandi Genderfemale CitizenshipEstonian Address Elva 6,<br />
50404 Tartu Educational historyUniversity <strong>of</strong> Tartu, Medical Faculty, 1989 Academic degreeDoctor<br />
<strong>of</strong> Medical Sciences, 1999 Employment and pr<strong>of</strong>essional experiences1989- Tartu University Clinics,<br />
United Laboratories – Bacteriologist; 1991-1993 internship in Tartu University Clinics; 1995- licensed<br />
bacteriologist; 1999- Dept Microbiology, University <strong>of</strong> Tartu – Researcher Special courses: 4<br />
months fellowship in National Public Health Institute, Helsinki (1993), 3 month fellowship in University<br />
<strong>of</strong> Lund (1994); 1 months fellowship in National Public Health Institute, Helsinki (1995); Administrative<br />
experiences Honours and awardsAward <strong>of</strong> Medical Faculty <strong>of</strong> University <strong>of</strong> Tartu (1999, 2000);<br />
Award <strong>of</strong> Tartu University Clinics (1999) Membership in academic and scientific societiesEstonian<br />
Society for Infectious Diseases, Estonian Society <strong>of</strong> Laboratory Medicine; Estonian Society for Sexually<br />
Transmitted Diseases Current research program and grantsNosocomial infections and antimicrobial<br />
susceptibility; biocides Supervision <strong>of</strong> dissertations Publications Totally 35, including 5 international<br />
and 2 Estonian articles<br />
MÄNDAR, REET Date <strong>of</strong> birth: June 10, 1964 3. Gender: female 4. Citizenship: Estonian 5. Address:<br />
Mõisavahe 60-37, Tartu 50707, Estonia 6. Educational history: University <strong>of</strong> Tartu, Medical Faculty,<br />
physician 1988. 7. Academic degrees: Doctor <strong>of</strong> medical sciences, University <strong>of</strong> Tartu, 1996. "Vaginal<br />
micr<strong>of</strong>lora during pregnancy and its transmission to newborn". 8. Employment and pr<strong>of</strong>essional<br />
experience: 1988-1990 resident in <strong>Department</strong> <strong>of</strong> Microbiology, University <strong>of</strong> Tartu 1990-1996 postgraduate<br />
student in Institute <strong>of</strong> General and Molecular Pathology, and <strong>Department</strong> <strong>of</strong> Microbiology,<br />
University <strong>of</strong> Tartu 1991-1995 doctor-bacteriologist in Tartu University Hospital 1994 II category <strong>of</strong><br />
doctor-bacteriologist 1993-1994 and 1995-1997 assistant lecturer in <strong>Department</strong> <strong>of</strong> Microbiology, University<br />
<strong>of</strong> Tartu 1997-2000 lecturer in <strong>Department</strong> <strong>of</strong> Microbiology, University <strong>of</strong> Tartu From 2000 associate<br />
pr<strong>of</strong>essor in <strong>Department</strong> <strong>of</strong> Microbiology, University <strong>of</strong> Tartu Research training: 3 months in<br />
Sweden, University <strong>of</strong> Lund – scholarship from Crawford Foundation for investigating <strong>the</strong> properties <strong>of</strong><br />
Helicobacteri pylori 4 months in USA, Indiana University - scholarship for studying health care administration<br />
and laboratory medicine, arranged by Pr<strong>of</strong>essional Training Fellowship Program. The program<br />
109
SECTION I: APPENDIXES<br />
was supported by Agency <strong>of</strong> International Development (USAID), The Soros Foundation's Management<br />
Training Program (SFMTP) ja Council on International Programs (CIP). 1 week in Sweden,<br />
Karolinska Institute – <strong>the</strong> course “Ecology and Importance <strong>of</strong> <strong>the</strong> Indigenous Micr<strong>of</strong>lora”. 9. Administrative<br />
experience: no 10. Honours/awards: Annual award <strong>of</strong> Committee for Scientific Awards <strong>of</strong><br />
Estonian Republic in 1994 for medical research: Marika Mikelsaar, Anne Ormisson, Urmas Siigur, Epp<br />
Sepp, Reet Mändar, Irja Lutsar, Heili Varendi “Regulating <strong>the</strong> newborn’s health by micr<strong>of</strong>lora” (<strong>the</strong>oretical-clinical<br />
research in1993-1994). 11. Membership in academic and scientific societies: Member<br />
<strong>of</strong> Estonian Society for Infectious Diseases. Member <strong>of</strong> Estonian Society for Medical Microbiology.<br />
12. Current research program and grants: Antibacterial susceptibility <strong>of</strong> lactobacilli <strong>of</strong> different origin.<br />
Significance <strong>of</strong> opportunistic microorganisms in <strong>the</strong> etiology <strong>of</strong> chronic prostatitis/chronic pelvic<br />
pain syndrome and <strong>the</strong>ir sexual transmission Current grant funding: Grant <strong>of</strong> Estonian Science<br />
Foundation No 4398 (years 2000-2002) “Significance <strong>of</strong> opportunistic microorganisms in <strong>the</strong> etiology<br />
<strong>of</strong> chronic prostatitis/chronic pelvic pain syndrome and <strong>the</strong>ir sexual transmission” - 70 000 EEK for<br />
year 2000. 13. Supervision <strong>of</strong> dissertations: Supervising postgraduate student <strong>of</strong> <strong>Department</strong> <strong>of</strong><br />
Stomatolgy Piret Kõll-Klais in microbiology for performing her Ph. D. <strong>the</strong>sis “Microbiological aspects<br />
and <strong>the</strong> role <strong>of</strong> inflammatory cytokines in <strong>the</strong> patohogenesis <strong>of</strong> periodontal diseases” (currently). 14.<br />
Publications: 52, 15 <strong>of</strong> <strong>the</strong>m 1995-2000. Seven papers in CC-referred journals.<br />
KASENÕMM, PRIIT Date <strong>of</strong> birth:25.02.1975 Gender:male Citizenship:Estonia Address:Ravila 19,<br />
Tartu Educational history:1993-2000 University <strong>of</strong> Tartu,medical faculty Academic digrees:- Employment<br />
and1996-2000 <strong>Department</strong> <strong>of</strong> Microbiology, pr<strong>of</strong>essional experience:technician Administrative<br />
experience:- Honours and awards:- Membership in academicMember <strong>of</strong> Society for Intestinal<br />
and scientific societies:Microbial Ecology and Disease Current research programDetection <strong>of</strong><br />
aerobic and anaerobic and grants:bacteremia during tonsillectomy. Comparison <strong>of</strong> aerobic and anaerobic<br />
microbial flora and patomorphological findings in palatine tonsils. Supervision <strong>of</strong> dissertations:-<br />
Publications: Lõivukene K., Kolk H., Maaroos H.-I., Kasenõmm P., Aro H., Ustav M. and<br />
Mikelsaar M. Metronidazole and clarithromycin susceptibility and <strong>the</strong> subtypes <strong>of</strong> vacA <strong>of</strong> Helicobacter<br />
pylori isolates in Estonia. Scand J Infect Dis 2000; 32: 59-62. Kasenõmm P. Krooniline retsidiveeruv<br />
tonsilliit. Eesti Arst 2000; 79(8): 481-485.<br />
NAABER, PAUL Date <strong>of</strong> birth1966-12-07, Tartu Gendermale CitizenshipEstonian Address Ravila 19,<br />
50411 Tartu Educational historyUniversity <strong>of</strong> Tartu, Medical Faculty, 1991 Academic degreeDoctor<br />
<strong>of</strong> Medical Sciences, 1997 Employment and pr<strong>of</strong>essional experiences1992-1997 Tartu University<br />
Clinics, United Laboratories – Bacteriologist; 1998 – 2000 Tartu University Clinics, United Laboratories<br />
–Head <strong>of</strong> Lab Clin Microbiology; 2000 – Tartu University Clinics, United Laboratories –Head <strong>of</strong> Dept<br />
Clin Microbiology; 1996-1998 Dept Microbiology, University <strong>of</strong> Tartu – Assistant; 1998- Dept Microbiology,<br />
University <strong>of</strong> Tartu – Senior Researcher Special courses: 6 months fellowship in University <strong>of</strong><br />
Turku (1994), 1 month fellowship in University <strong>of</strong> Uppsala (1992); Course <strong>of</strong> anaerobic microbiology<br />
(University <strong>of</strong> Udine, Italy 1995); Course <strong>of</strong> intestinal microbial ecology (Karolinska Institute, Sweden,<br />
1997); Course <strong>of</strong> Nosocomial Infections (ESCMID, Madrid, 1998) Administrative experiencesHead<br />
<strong>of</strong> Dept Clinical Microbiology, United Laboratories (1998-) Honours and awardsAward <strong>of</strong> Society for<br />
Anaerobic Microbiology (1997); Award <strong>of</strong> Medical Faculty <strong>of</strong> University <strong>of</strong> Tartu (1999, 2000); Award <strong>of</strong><br />
Tartu University Clinics (1999) Membership in academic and scientific societiesEstonian Society<br />
for Infectious Diseases, Estonian Society <strong>of</strong> Laboratory Medicine; Anaerobe Society <strong>of</strong> Americas;<br />
European Society <strong>of</strong> Clinical Microbiology and Infectious Diseases Current research program and<br />
grantsNosocomial infections and antimicrobial susceptibility; in vitro and in vivo models <strong>of</strong> infections<br />
Supervision <strong>of</strong> dissertations Imbi Smidt, M.Sc. 1999 (In vitro ja in vivo interaction <strong>of</strong> indigenous intestinal<br />
lactobacilli and opportunistic pathogens – Clostridium difficile and Escherichia coli) Publications<br />
Totally 64, including 11 international and 6 Estonian articles<br />
KRISPIN, TÕNU Date <strong>of</strong> birth: March 23, 1939 Gender: man Citizenship: Estonia Address: Tartu,<br />
Kaunase str. 44-14 Educational history: graduated from Medical Faculty <strong>of</strong> Tartu University in 1963<br />
Academic degrees: medical candidate (Ph.D) - virology - 1967 Doctor <strong>of</strong> Biological Sciences in<br />
molecular biology - Moscow - 1990 Employment and pr<strong>of</strong>essional experience: 1964-1967 -<br />
postgraduate student in <strong>the</strong> Institute <strong>of</strong> Microbiology and Epidemiology (Gamaleya) <strong>of</strong> Russian AMS<br />
(Moscow) 1967-1969 - junior scientific worker in <strong>the</strong> same institute 1969-1972 - senior scientific worker<br />
in <strong>the</strong> Institute <strong>of</strong> Epidemiology, Microbiology and Hygiene <strong>of</strong> Tallinn 1973-1992 - at <strong>the</strong> beginning as a<br />
junior, <strong>the</strong>n senior and at last as a leading scientific worker in <strong>the</strong> Institute <strong>of</strong> Gamaleya (Moscow)<br />
1992-1993 - associate pr<strong>of</strong>essor <strong>of</strong> <strong>Department</strong> <strong>of</strong> Microbiology, Tartu University 1993-1998 -<br />
extraordinary pr<strong>of</strong>essor <strong>of</strong> <strong>Department</strong> <strong>of</strong> Microbiology, Tartu University 1998- associate pr<strong>of</strong>essor<br />
(virology) <strong>of</strong> <strong>Department</strong> <strong>of</strong> Microbiology, Tartu University Administrative experience: no Honours<br />
and awards: no Membership in academic and scientific societies: member <strong>of</strong> European Society<br />
110
MICROBIOLOGY<br />
for Clinical Virology (ESCV), past member (10 years) <strong>of</strong> International Society <strong>of</strong> Interferon Research<br />
Current research program and grants: Molecular epidemiology and molecular biology <strong>of</strong> hepatitis C<br />
and B viruses; cytokines; molecular virology. Participation in <strong>the</strong> European Union Copernicus Grant<br />
IC15-CT 98-0319 Molecular monitoring and pathological role <strong>of</strong> altered HBV and HCV genomes in<br />
patients with chronic hepatitis. Molecular biology <strong>of</strong> nonstructural proteins <strong>of</strong> hepatitis C virus.<br />
Supervision <strong>of</strong> dissertations: scientific leadership <strong>of</strong> 3 biological candidates (Shloma,<br />
Kalmakhelidze, Solovyova) in Moscow (<strong>the</strong> last <strong>of</strong>ficially). All <strong>of</strong> <strong>the</strong>m graduated successfully.<br />
Publications: number <strong>of</strong> publications 69 (incl. 18 international publications), 8 <strong>of</strong> <strong>the</strong>m 1995-2000 + 7<br />
handouts concerning medical microbiology, so total nuber <strong>of</strong> publications is 76.<br />
KARKI, TÕNIS Date <strong>of</strong> birth: 24. December 1963 a. Gender: male Citizenship: Estonian Adress: Ravila<br />
19, Tartu, Estonia Educational history: University <strong>of</strong> Tartu, Faculty <strong>of</strong> Medicine 1988 Academic<br />
degrees: dr. med 1966, University <strong>of</strong> Tartu Employment and pr<strong>of</strong>essional experience: 1988 -<br />
postgraduate student at <strong>the</strong> <strong>Department</strong> <strong>of</strong> microbiology, 1989 - assistant, 1996 lecturer, 1997 - docent<br />
Membership in academic and scientific societies: 1994-1999 Chairman <strong>of</strong> <strong>the</strong> Estonian Society<br />
<strong>of</strong> Medical Microbiology, member <strong>of</strong> <strong>the</strong> European Study Group <strong>of</strong> Antibiotic Resistance (ESCAR)<br />
Current research activities: antimicrobial resistance, human micr<strong>of</strong>lora. Publications: 63<br />
TRUUSALU, KAI Date <strong>of</strong> birth:25.02.1965 Gender:female Citizenship:Estonia Address:Ravila 19, Tartu<br />
Educational history:1983-1998 University <strong>of</strong> Tartu, medical faculty Academic digrees:- Employment<br />
and1998-1999 <strong>Department</strong> <strong>of</strong> Microbiology, pr<strong>of</strong>essional experience:assistant Administrative<br />
experience:- Honours and awards:- Membership in academic and scientific societies: Current<br />
research program Genotyping recurrent urinary tract infections caused by E. coli Supervision <strong>of</strong><br />
dissertations:- Publications: 3<br />
BRILENE, TATJANA Date <strong>of</strong> birth:14.07.1955 Gender:Female Citizenship: Estonia Address: Tatumaa<br />
Ülenurme v. Soinaste 68, tel. 362 384 Educational history: 1962-1972 Tartu 6 School 1973-1979<br />
MD, Diploma <strong>of</strong> Medical Faculty <strong>of</strong> Tartu University resident <strong>of</strong> <strong>Department</strong> <strong>of</strong> Microbiology <strong>of</strong> Tartu<br />
University 1981-1986 Postgraduate student <strong>of</strong> <strong>Department</strong> <strong>of</strong> Microbiology <strong>of</strong> Tartu University 7.<br />
Academic degrees: 1991 PhD., Moskva Gabrichevsky Medical Insitute 8.Employment and<br />
pr<strong>of</strong>essional experience: 1986-1991 junior research associate <strong>of</strong> <strong>Department</strong> <strong>of</strong> Microbiology <strong>of</strong><br />
Tartu University 1991-1995 senior assistant <strong>of</strong> <strong>Department</strong> <strong>of</strong> Microbiology <strong>of</strong> Tartu University 1995-<br />
2000 assistant pr<strong>of</strong>fesor <strong>of</strong> <strong>Department</strong> <strong>of</strong> Microbiology <strong>of</strong> Tartu University 2000-2005 senior assistant<br />
<strong>of</strong> <strong>Department</strong> <strong>of</strong> Microbiology <strong>of</strong> Tartu University 11. Membership in academic and scientific<br />
societies: Member <strong>of</strong> Estonian Society <strong>of</strong> Microbiology Member <strong>of</strong> Board <strong>of</strong> Estonian Union <strong>of</strong> STDs<br />
12. Current research programm: Human micr<strong>of</strong>lora; Prevalence <strong>of</strong> Vaginal Lactobacili in Women<br />
During Induction <strong>of</strong> Superovulation in IVF programm 14. Publications: 96; Certificates <strong>of</strong> invention<br />
:”Method for study <strong>of</strong> adhesion <strong>of</strong> microorganisms” nr.1076441 (1984), “Strains <strong>of</strong> Lactobacilli for<br />
probiotics” nr.1517352, nr.1517353,nr.1517354 (1989).<br />
111
PATHOLOGICAL <strong>ANATOMY</strong> AND FORENSIC MEDICINE<br />
<strong>Name</strong> <strong>of</strong> <strong>Department</strong>: <strong>Department</strong> <strong>of</strong> Pathological Anatomy and<br />
Forensic Medicine<br />
Head <strong>of</strong> <strong>the</strong> <strong>Department</strong>: Pr<strong>of</strong>essor Raik-Hiio Mikelsaar<br />
<strong>Name</strong> e<strong>of</strong> <strong>the</strong> Chair: Pathological Anatomy:<br />
Head <strong>of</strong> <strong>the</strong> chair: Pr<strong>of</strong>essor Raik-Hiio Mikelsaar<br />
Subject codes: ARPA.01.014; ARPA.01.008<br />
I. CONTENT OF THE TEACHING<br />
1. Describe shortly <strong>the</strong> main study and student evaluation methods applied at<br />
<strong>the</strong> department.<br />
The main study includes teaching <strong>of</strong> pathology – <strong>the</strong> etiopathogenesis and<br />
characteristics <strong>of</strong> <strong>of</strong> diseases. Lecture-seminars and practical trainings are<br />
carried out. Students are evaluated by current tests and a final examination.<br />
2. How have <strong>the</strong> aims and objectives described in <strong>the</strong> curriculum changed<br />
during <strong>the</strong> past five years?<br />
According to <strong>the</strong> general trends in <strong>the</strong> development <strong>of</strong> pathology, in our course<br />
now <strong>the</strong> morphological descriptions <strong>of</strong> diseases are widely accompanied by<br />
explanation <strong>of</strong> etiopathogenetic mechanisms. Both general and systematic<br />
pathology are studied on lecture-seminars and practical trainings. A logical<br />
sequence <strong>of</strong> general course is applied: initially alterative changes, <strong>the</strong>n inflammatory<br />
processes and finally disorders <strong>of</strong> proliferative-differentiation processes<br />
including tumours are presented. Compared to <strong>the</strong> earlier curriculum,<br />
more emphasis is now paid to <strong>the</strong> molecular pathology and coordination <strong>of</strong><br />
teaching with o<strong>the</strong>r <strong>the</strong>oretical institutes and clinics.<br />
3. Describe <strong>the</strong> strengths and weaknesses <strong>of</strong> <strong>the</strong> teaching in your department.<br />
Strengths<br />
1. The pathology is accepted by students as a basic field <strong>of</strong> medicine and<br />
most <strong>of</strong> <strong>the</strong>m are continuously participating in lecture-seminars and practical<br />
trainings.<br />
2. The information (a text and illustrations) presented on lecture-seminars is<br />
available in a typed form (1200 pages).<br />
3. There is a large collection <strong>of</strong> macro- and micropreparations provided by<br />
description – brochures used for practical trainings.<br />
Weaknesses<br />
Some members <strong>of</strong> staff do not still have a Ph.D degree.<br />
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SECTION I: SELF-EVALUATION<br />
4. Describe <strong>the</strong> innovations in your teaching.<br />
1. Several parts <strong>of</strong> <strong>the</strong>oretical material are presented in <strong>the</strong> original form<br />
(dystrophia, mucosis and mucoidosis, nephronecrosis etc).<br />
2. Computer-aided and video-recording methods <strong>of</strong> teaching are introduced<br />
both in <strong>the</strong>oretical and practical training.<br />
3. New elective problem-oriented courses (inflammatory diseases, autopsy<br />
analysis) are <strong>of</strong>fered for students.<br />
4. A special test is applied at <strong>the</strong> end <strong>of</strong> each lecture-seminar.<br />
5. <strong>Name</strong> <strong>the</strong> factors which most disturb teaching (excluding financial resources).<br />
1. There is too short time given for course <strong>of</strong> pathology, many branches (for<br />
example brain, skin and bone pathology) remain poorly presented.<br />
2. The rooms available for practical training and individual work are too small.<br />
II. EVALUATION OF TEACHING<br />
6. How is <strong>the</strong> quality <strong>of</strong> <strong>the</strong> teaching in your department evaluated? How are<br />
<strong>the</strong> content and <strong>the</strong> modes <strong>of</strong> <strong>the</strong> teaching changed on <strong>the</strong> basis <strong>of</strong> <strong>the</strong><br />
evaluation?<br />
114<br />
A systematic questionnaire-based student evaluation has been carried out at<br />
<strong>the</strong> end <strong>of</strong> <strong>the</strong> pathology course. The results <strong>of</strong> this evaluation have been discussed<br />
on a staff meeting and critical comments are considered to improve<br />
<strong>the</strong> teaching work.<br />
III. PEDAGOGIC TRAINING OF STAFF<br />
7. How many <strong>of</strong> <strong>the</strong> teachers have received pedagogic training?<br />
All staff has got a practical training during <strong>the</strong>ir pedagogic work. The head <strong>of</strong><br />
department has during several years participated in discussions on <strong>the</strong> optimal<br />
forms <strong>of</strong> lecture-seminars.<br />
8. Is <strong>the</strong>re a need for fur<strong>the</strong>r pedagogic training?<br />
An additional special training would be useful for development <strong>of</strong> pedagogic<br />
work quality.<br />
IV. TEACHING RESOURCES<br />
9. Is <strong>the</strong>re a need for rearrangement <strong>of</strong> <strong>the</strong> teaching resources in your department?<br />
If so, how should this be done?
PATHOLOGICAL <strong>ANATOMY</strong> AND FORENSIC MEDICINE<br />
At <strong>the</strong> current moment <strong>the</strong>re is no need for rearrangement <strong>of</strong> <strong>the</strong> teaching resources.<br />
V. COORDINATION OF THE TEACHING<br />
10. How is <strong>the</strong> teaching co-ordinated with o<strong>the</strong>r departments? Indicate <strong>the</strong> departments<br />
that are closest to your department.<br />
Because <strong>the</strong> pathology is a basic field <strong>of</strong> medicine, <strong>the</strong> teaching must be coordinated<br />
with many o<strong>the</strong>r departments. Correlation are made both in <strong>the</strong> terminology<br />
and <strong>the</strong> content <strong>of</strong> teaching programs. The closest branches <strong>of</strong><br />
medicine are: histology, biochemistry, physiology, microbiology, immunology.<br />
VI. FUTURE PLANS<br />
11. Future plans to improve <strong>the</strong> teaching given by <strong>the</strong> department.<br />
The teaching methods and programs should be improved according to <strong>the</strong> development<br />
<strong>of</strong> pathology. All staff may have a Ph.D degree. It would be reasonable<br />
to teach <strong>the</strong> pathology instead <strong>of</strong> one semester during two semesters.<br />
Larger rooms are needed for practical training. Fur<strong>the</strong>r co-ordination between<br />
departments should be developed.<br />
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SECTION I: SELF-EVALUATION<br />
<strong>Name</strong> <strong>of</strong> <strong>Department</strong>: <strong>Department</strong> <strong>of</strong> Pathological Anatomy and<br />
Forensic Medicine<br />
Head <strong>of</strong> <strong>the</strong> <strong>Department</strong>: Pr<strong>of</strong>essor Raik-Hiio Mikelsaar<br />
<strong>Name</strong> <strong>of</strong> <strong>the</strong> Chair: Chair <strong>of</strong> Forensic Medicine<br />
Head <strong>of</strong> <strong>the</strong> chair: Docent Marika Väli<br />
Subject codes: ARPA.02.001<br />
I. CONTENT OF THE TEACHING<br />
1. Describe shortly <strong>the</strong> main study and student evaluation methods applied at<br />
<strong>the</strong> department.<br />
The course gives students basic knowledge <strong>of</strong> forensic medicine and understanding<br />
<strong>of</strong> solving <strong>the</strong> medical-biological problems, which rise up during proceeding<br />
criminal and civil cases.<br />
Teaching methods are lectures, seminars, practical classes and independent<br />
study. The seminars are problem-oriented and <strong>the</strong> students have to prepare<br />
previously so that <strong>the</strong>y are able to discuss different <strong>the</strong>mes and analyse cases<br />
<strong>of</strong> forensic medicine. Each student has to solve 5 situation-exercises <strong>of</strong> forensic<br />
medicine cases as homework, perform and analyse <strong>the</strong> cases and give<br />
reasons <strong>of</strong> <strong>the</strong>ir decisions in <strong>the</strong> seminar. This work is evaluated. Practical<br />
classes are <strong>the</strong> carried out as <strong>the</strong> demonstrations <strong>of</strong> autopsies and in some<br />
cases students are allowed to dissect by <strong>the</strong>mselves. At <strong>the</strong> end <strong>of</strong> <strong>the</strong> course<br />
<strong>the</strong> students have to pass <strong>the</strong> written examination.<br />
2. How have <strong>the</strong> aims and objectives described in <strong>the</strong> curriculum changed<br />
during <strong>the</strong> past five years?<br />
The aims and objectives in <strong>the</strong> curriculum have not changed notably, but as<br />
<strong>the</strong> possibilities <strong>of</strong> teaching have improved and new problems in <strong>the</strong> field <strong>of</strong> forensic<br />
medicine have became actual emphasis <strong>of</strong> some <strong>the</strong>mes have been<br />
shifted.<br />
1. The state-<strong>of</strong>-<strong>the</strong>-art facility enables to introduce to <strong>the</strong> students <strong>the</strong> laboratory<br />
investigations: forensic toxicological, DNA and forensic anthropologic<br />
investigations.<br />
2. As <strong>the</strong> problem <strong>of</strong> medical malpractice has became quite actual more attention<br />
is paid to discuss and analyse <strong>the</strong> examples <strong>of</strong> problematic cases.<br />
This gives a good opportunity to link <strong>the</strong>oretical knowledge with practical<br />
examples. Considering <strong>the</strong> <strong>the</strong>me <strong>the</strong> students are given an understanding<br />
<strong>of</strong> <strong>the</strong> importance <strong>of</strong> correct and thorough filling <strong>of</strong> medical documents and<br />
possible consequences <strong>of</strong> being unconscientious in <strong>the</strong>ir work.<br />
116<br />
3. More attention is paid to introduce <strong>the</strong> legislation that would be necessary<br />
to <strong>the</strong> doctors in <strong>the</strong>ir future work.
PATHOLOGICAL <strong>ANATOMY</strong> AND FORENSIC MEDICINE<br />
3. Describe <strong>the</strong> strengths and weaknesses <strong>of</strong> <strong>the</strong> teaching in your department.<br />
Strengths<br />
1. Students have <strong>the</strong> possibility to watch closely <strong>the</strong> autopsies and in some<br />
cases even carry out <strong>the</strong> autopsies by <strong>the</strong>mselves. It gives <strong>the</strong>m good understanding<br />
<strong>of</strong> <strong>the</strong> speciality and makes <strong>the</strong>m remember <strong>the</strong>ir knowledge <strong>of</strong><br />
anatomy and pathological anatomy.<br />
2. Situation-exercises <strong>of</strong> cases <strong>of</strong> forensic medicine make <strong>the</strong> students operate<br />
with <strong>the</strong> obtained <strong>the</strong>oretical knowledge and put it into practice. They<br />
are given three types <strong>of</strong> excersises: a) crime scene investigation (by photos);<br />
b) forensic expertise <strong>of</strong> living person; c) forensic expertise <strong>of</strong> dead<br />
body. Working through <strong>the</strong> cases students train to describe <strong>the</strong> crime<br />
scene and post-morten changes <strong>of</strong> <strong>the</strong> dead body, estimate time <strong>of</strong> death,<br />
describe injuries, determine <strong>the</strong> cause <strong>of</strong> death, compose <strong>the</strong> forensic<br />
medical diagnosis and expert opinion, fill <strong>the</strong> certificate <strong>of</strong> death and so on.<br />
All <strong>the</strong> cases are discussed in <strong>the</strong> seminars and this makes possible to correct<br />
misunderstandings and students have <strong>the</strong> opportunity to ask <strong>the</strong><br />
teachers questions that have rised up. By this kind <strong>of</strong> training it is easy to<br />
justify <strong>the</strong> speciality as important.<br />
3. We have a unique collection <strong>of</strong> macro-preparations that are <strong>of</strong> great help in<br />
teaching pathological changes <strong>of</strong> organs due to diseases and injuries.<br />
4. In <strong>the</strong> seminars we use a collection <strong>of</strong> colour slides and CD-ROM <strong>of</strong> forensic<br />
pathology atlas.<br />
5. Students get a good view <strong>of</strong> different laboratory investigations that are<br />
used in forensic medicine.<br />
6. As we have had good contacts with several European universities we have<br />
already started to harmonize our curriculum with <strong>the</strong> curriculum used in<br />
o<strong>the</strong>r European universities.<br />
Weaknesses<br />
1. Our staff has not trained <strong>the</strong>ir pedagogic skills.<br />
2. Sometimes we still tend to teach too much <strong>the</strong>ory and tend to forget that<br />
we are teaching young doctors who are <strong>of</strong>ten more interested in clinical<br />
disciplines than in our speciality and that it is up to us to arouse <strong>the</strong>ir interest<br />
to forensic medicine. This can be done only by showing <strong>the</strong>m <strong>the</strong> links<br />
between forensic medicine and clinic and make <strong>the</strong>m think about <strong>the</strong> juridical<br />
side <strong>of</strong> <strong>the</strong>ir future work.<br />
3. In <strong>the</strong> lectures <strong>the</strong>re could be used much more computer-aided teaching<br />
methods (for example CD-ROMs <strong>of</strong> forensic pathology, slide shows in<br />
Power Point program).<br />
4. As our staff is quite young and has worked as a team only 5 years we have<br />
not managed to publish enough textbooks in Estonian, which students<br />
could easily use for independent study.<br />
5. We do not demonstrate micro-preparations to <strong>the</strong> students.<br />
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SECTION I: SELF-EVALUATION<br />
4. Describe <strong>the</strong> innovations in your teaching.<br />
1. During last year computer-aided teaching methods have been taken into<br />
use as a complement to <strong>the</strong> traditional teaching methods. We use <strong>the</strong> CD-<br />
ROM <strong>of</strong> forensic pathology and <strong>the</strong> first lectures and seminars have been<br />
carried out as slide shows prepared in PowerPoint program.<br />
2. We use X-ray photos for explaining mechanisms <strong>of</strong> trauma in <strong>the</strong> seminars<br />
and practical classes.<br />
3. The teaching staff <strong>of</strong> <strong>the</strong> Chair has published two textbooks <strong>of</strong> forensic<br />
medicine during last 2 years in Estonian that enables <strong>the</strong> students to learn<br />
in <strong>the</strong>ir native language (before it <strong>the</strong> last manual <strong>of</strong> forensic medicine was<br />
published in 1938).<br />
4. The staff <strong>of</strong> <strong>the</strong> Chair has prepared a number <strong>of</strong> video recordings <strong>of</strong> forensic<br />
medical cases that can be used in <strong>the</strong> seminars.<br />
5. <strong>Name</strong> <strong>the</strong> factors which most disturb teaching (excluding financial resources).<br />
1. The groups <strong>of</strong> students participating in <strong>the</strong> seminars and practical classes<br />
(14-18 students) are larger than optimal. We consider <strong>the</strong> optimal number<br />
<strong>of</strong> students in <strong>the</strong> group not more than 10.<br />
2. The volume <strong>of</strong> <strong>the</strong> course has been decreased several times and we cannot<br />
give <strong>the</strong> students as thorough knowledge as necessary due to <strong>the</strong> limited<br />
time.<br />
3. Lack <strong>of</strong> literature <strong>of</strong> forensic medicine in libraries. During last years <strong>the</strong><br />
Chair has bought several books and manuals <strong>of</strong> <strong>the</strong> speciality for staff, but<br />
in <strong>the</strong> libraries <strong>the</strong>re are still only single copies <strong>of</strong> some books, textbooks<br />
and manuals for students. We have also asked several times for subscription<br />
<strong>of</strong> any journal <strong>of</strong> forensic medicine, but due to financial problems we<br />
have never got it.<br />
4. In <strong>the</strong> room we carry out <strong>the</strong> seminars <strong>the</strong>re are no conditions for holding<br />
macro-preparations (no special cupboards, shelves or ventilation) and we<br />
have to transport <strong>the</strong> preparations from one floor to <strong>the</strong> o<strong>the</strong>r for demonstrations.<br />
5. The students have forgotten a lot <strong>of</strong> knowledge <strong>of</strong> anatomy and pathological<br />
anatomy <strong>the</strong>y had obtained at <strong>the</strong> first years <strong>of</strong> study.<br />
II. EVALUATION OF TEACHING<br />
6. How is <strong>the</strong> quality <strong>of</strong> <strong>the</strong> teaching in your department evaluated? How are<br />
<strong>the</strong> content and <strong>the</strong> modes <strong>of</strong> <strong>the</strong> teaching changed on <strong>the</strong> basis <strong>of</strong> <strong>the</strong><br />
evaluation?<br />
118<br />
During <strong>the</strong> last 2 years after passing <strong>the</strong> course <strong>the</strong> students have been asked<br />
to fill anonymously <strong>the</strong> questionnaires evaluating <strong>the</strong> teaching. The students’<br />
evaluation <strong>of</strong> teaching has been mostly favourable; we have got only a few<br />
critical comments. Students have proposed to have more practical classes
PATHOLOGICAL <strong>ANATOMY</strong> AND FORENSIC MEDICINE<br />
(autopsies) and we have taken it into consideration and increased <strong>the</strong> amount<br />
<strong>of</strong> hours <strong>of</strong> practical classes.<br />
Some teachers and students get a very good contact in seminars and practical<br />
classes and work in an open atmosphere. This allows immediate direct<br />
feedback and <strong>the</strong>se teachers are also highly evaluated by <strong>the</strong> students.<br />
From <strong>the</strong> beginning <strong>of</strong> this year <strong>the</strong> University has started with <strong>the</strong> new systematic<br />
evaluation <strong>of</strong> teaching and so we have got only <strong>the</strong> very first results,<br />
but it seems that in principle <strong>the</strong>y do not notably differ from <strong>the</strong> results we have<br />
got before.<br />
III. PEDAGOGIC TRAINING OF STAFF<br />
7. How many <strong>of</strong> <strong>the</strong> teachers have received pedagogic training?<br />
One assistant has attended at two short courses, three days all toge<strong>the</strong>r. The<br />
docent has taken part in one one-day course.<br />
8. Is <strong>the</strong>re a need for fur<strong>the</strong>r pedagogic training?<br />
Fur<strong>the</strong>r pedagogic training is very necessary and we hope that <strong>the</strong> University<br />
would arrange <strong>the</strong> courses in <strong>the</strong> future.<br />
IV. TEACHING RESOURCES<br />
9. Is <strong>the</strong>re a need for rearrangement <strong>of</strong> <strong>the</strong> teaching resources in your department?<br />
If so, how should this be done?<br />
The teaching staff <strong>of</strong> <strong>the</strong> Chair is made up <strong>of</strong> one docent and two assistants.<br />
As <strong>the</strong> teaching staff <strong>of</strong> <strong>the</strong> Chair is quite young (average age 35 years) only<br />
<strong>the</strong> docent has <strong>the</strong> scientific degree. But two postgraduate students are preparing<br />
<strong>the</strong> <strong>the</strong>sis for a Doctor’s degree, one <strong>of</strong> <strong>the</strong>m is <strong>the</strong> assistant <strong>of</strong> <strong>the</strong><br />
Chair. So we hope to get two young doctors <strong>of</strong> medicine in next two-three<br />
years.<br />
V. COORDINATION OF THE TEACHING<br />
10. How is <strong>the</strong> teaching co-ordinated with o<strong>the</strong>r departments? Indicate <strong>the</strong> departments<br />
that are closest to your department.<br />
Forensic medicine is <strong>the</strong> clinical subject and students must have preliminary<br />
knowledge <strong>of</strong> anatomy and pathological anatomy, clinical specialities like<br />
traumatology, intensive care, neurology and many o<strong>the</strong>rs.<br />
Closest to our Chair is <strong>the</strong> Chair <strong>of</strong> Pathological Anatomy. Both specialities<br />
teach <strong>the</strong> morphological findings <strong>of</strong> pathological changes in organs and determing<br />
<strong>the</strong> cause <strong>of</strong> death, but <strong>the</strong> Chair <strong>of</strong> Forensic Medicine pays most at-<br />
119
SECTION I: SELF-EVALUATION<br />
120<br />
tention to teaching <strong>the</strong> investigation and describing <strong>of</strong> injuries and changes in<br />
<strong>the</strong> organs due to external factors not diseases.<br />
VI. FUTURE PLANS<br />
11. Future plans to improve <strong>the</strong> teaching given by <strong>the</strong> department.<br />
1. According to <strong>the</strong> new program forensic medicine is going to be taught at<br />
<strong>the</strong> 6 th course. We consider it very positive because <strong>the</strong> students have already<br />
obtained basic clinical knowledge and would have quite good medical<br />
thinking. So <strong>the</strong> emphasis shifts more to <strong>the</strong> practical exercises and<br />
discussions <strong>of</strong> cases.<br />
2. Reduce <strong>the</strong> amount <strong>of</strong> lectures and increase <strong>the</strong> importance <strong>of</strong> independent<br />
study.<br />
3. Increase <strong>the</strong> amount <strong>of</strong> seminars where <strong>the</strong> cases <strong>of</strong> living persons are<br />
discussed and enable <strong>the</strong> students taking part in examination <strong>of</strong> <strong>the</strong> injured<br />
persons.<br />
4. We plan to use more computer-aided teaching methods in lectures.<br />
5. Make part <strong>of</strong> written materials <strong>of</strong> <strong>the</strong> lectures and seminars available at our<br />
homepage by Internet.<br />
6. Publish new textbooks in Estonian.<br />
7. Demonstrate <strong>the</strong> micro-preparations in seminars and practical classes.
PATHOLOGICAL <strong>ANATOMY</strong> AND FORENSIC MEDICINE<br />
Pathological anatomy: resource evaluation<br />
1. Study materials<br />
- How many study books are published in your institution during last five years? 3<br />
- Do you have separate room as library in your place? Yes No<br />
- Could students borrow study books from your institution? Yes No<br />
- Do you have on-line published study materials for students? Yes No<br />
- WWW address: http://biomedicum.ut.ee/arpa/<br />
- Does University library has enough modern books in your speciality?<br />
Completely enough Enough Scarcely Absolutely scarcely No<br />
2. Amount and size <strong>of</strong> study rooms<br />
- Rooms used by Your institution only: 1 rooms with area <strong>of</strong> 58,7 m 2<br />
- Rooms shared with ano<strong>the</strong>r institution: - rooms with area <strong>of</strong> - m 2<br />
- Do You have enough space for study process by Your opinion?<br />
Completely enough Enough Scarce Absolutely scarcely<br />
- How <strong>the</strong> scarce <strong>of</strong> space should be handled or changed?<br />
New building Change to smaller student groups Better logistics<br />
O<strong>the</strong>r way (describe shortly)<br />
3. Current situation <strong>of</strong> study rooms<br />
- There has been repairments in last years (except Biomedicum)<br />
- How are <strong>the</strong> study rooms lightened?<br />
Very good Good Some darkness Absolutely dark for study<br />
- Evaluation <strong>of</strong> general conditions: Very good Good Satisfactory Bad<br />
4. Your institution has<br />
a) 1 (how many?) auditorium(s) for workshops/seminars with 170 places, equipped with<br />
Blackboard<br />
White board & markers<br />
Screen<br />
Overhead projector<br />
Data projector<br />
Slide projector<br />
b) 1 (how many?) laboratories for practicals with 20 places, equipped with<br />
Blackboard<br />
White board and markers<br />
Screen<br />
Overhead projector<br />
Data projector<br />
Slide projection kit<br />
TV/Video projection set<br />
Computer<br />
Internet connection<br />
TV/Video projection kit<br />
Computer<br />
Internet connection<br />
5. Working rooms for teaching staff and postgraduate students:<br />
- Number <strong>of</strong> teaching staff 4<br />
- Number <strong>of</strong> rooms for staff 6<br />
- Number <strong>of</strong> individual working places 5, among <strong>the</strong>m with computers 4<br />
- Number <strong>of</strong> postgraduate students is 1<br />
- How many individual working places <strong>the</strong>y have? 1<br />
- How many computers <strong>the</strong>y have? 1<br />
6. O<strong>the</strong>r comments on resource topic (max 250 letters):<br />
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SECTION I: APPENDIXES<br />
Forensic medicine: resource evaluation<br />
1. Study materials<br />
- How many study books are published in your institution during last five years? 2<br />
- Do you have separate room as library in your place? Yes No<br />
- Could students borrow study books from your institution? Yes No<br />
- Do you have on-line published study materials for students? Yes No<br />
- WWW address: http://biomedicum.ut.ee/arpa<br />
- Does University library has enough modern books in your speciality?<br />
Completely enough Enough Scarcely Absolutely scarcely No<br />
2. Amount and size <strong>of</strong> study rooms<br />
- Rooms used by Your institution only: - rooms with area <strong>of</strong> - m 2<br />
- Rooms shared with ano<strong>the</strong>r institution: 2 rooms with area <strong>of</strong> 80 m 2<br />
- Do You have enough space for study process by Your opinion?<br />
Completely enough Enough Scarce Absolutely scarcely<br />
- How <strong>the</strong> scarce <strong>of</strong> space should be handled or changed?<br />
New building Change to smaller student groups Better logistics<br />
O<strong>the</strong>r way (describe shortly)<br />
3. Current situation <strong>of</strong> study rooms<br />
- There has been repairments in last years (except Biomedicum)<br />
- How are <strong>the</strong> study rooms lightened?<br />
Very good Good Some darkness Absolutely dark for study<br />
- Evaluation <strong>of</strong> general conditions: Very good Good Satisfactory Bad<br />
4. Your institution has<br />
a) 1 (how many?) auditorium(s) for workshops/seminars with 24 places, equipped with<br />
122<br />
Blackboard<br />
White board & markers<br />
Screen<br />
Overhead projector<br />
Data projector<br />
Slide projector<br />
b) 1 (how many?) laboratories for practicals with 30 places, equipped with<br />
Blackboard<br />
White board and markers<br />
Screen<br />
Overhead projector<br />
Data projector<br />
Slide projection kit<br />
TV/Video projection set<br />
Computer<br />
Internet connection<br />
TV/Video projection kit<br />
Computer<br />
Internet connection<br />
5. Working rooms for teaching staff and postgraduate students:<br />
- Number <strong>of</strong> teaching staff 3<br />
- Number <strong>of</strong> rooms for staff 3<br />
- Number <strong>of</strong> individual working places 2, among <strong>the</strong>m with computers 2<br />
- Number <strong>of</strong> postgraduate students is 2<br />
- How many individual working places <strong>the</strong>y have? 1<br />
- How many computers <strong>the</strong>y have? 1<br />
6. O<strong>the</strong>r comments on resource topic (max 250 letters): One assistant and one<br />
postgraduate student do not have <strong>the</strong> individual working places. The individual working<br />
place for <strong>the</strong> o<strong>the</strong>r postgraduate student has been established into <strong>the</strong> laboratory.
APPENDIX I-I<br />
PATHOLOGICAL <strong>ANATOMY</strong> AND FORENSIC MEDICINE<br />
Visits <strong>of</strong> <strong>the</strong> Dpartment members to o<strong>the</strong>r institutions abroad during 1996-2000<br />
Year Researcher/Lectures Institution Country Purpose Duration<br />
1996 Ilona Drikkit, assistant University <strong>of</strong> Goe<strong>the</strong>borg Sweden Research 1 week<br />
1998 Daily Lepik, assistant University <strong>of</strong> Turku Finland Training 2 weeks<br />
1998 Hannes Tamm, assistant University <strong>of</strong> Lund Sweden Research 3 months<br />
1999 Ilona Drikkit, assistant University <strong>of</strong> Turku Finland Training 2 weeks<br />
1999 Ilona Drikkit, assistant University <strong>of</strong> Copenhagen Denmark Training 2 weeks<br />
1999 Marika Väli, docent Institute <strong>of</strong> Forensic Medicine <strong>of</strong> Leipzig Germany Training 2 weeks<br />
2000 Ilona Drikkit, assistant University <strong>of</strong> Riga Latvia Research 1 week<br />
2000 Ingrid Mesila, assistant University Medical Caentral Utrecht Nederlands Training 3 weeks<br />
APPENDIX I-II<br />
Postgraduate students at <strong>the</strong> <strong>Department</strong> having studied abroad during 1996-2000<br />
Year <strong>Name</strong> Institution Contry Duration<br />
1998 Andres Kulla University <strong>of</strong> Mainz Germany 3 months<br />
1999 Andres Kulla University <strong>of</strong> Newcastle UK 5 weeks<br />
1999 Andres Kulla University <strong>of</strong> Helsinki Finland 1 week<br />
2000 Andres Kulla University <strong>of</strong> Helsinki Finland 1 week<br />
APPENDIX I-III<br />
Co-operation with institutions from o<strong>the</strong>r countries and participation in international<br />
research projects during 1996-2000<br />
Contact person Institution Country Aim <strong>of</strong> <strong>the</strong> collaboration<br />
Dr Andres Kulla University <strong>of</strong> Mainz Germany Teaching <strong>of</strong> Neuropathologie in Estonia<br />
Dr Andres Kulla University <strong>of</strong> Helsinki Finland Cooperation in transplantological pathology<br />
APPENDIX I-IV<br />
Visiting lecturers at <strong>the</strong> <strong>Department</strong> during 1996-2000<br />
Visitor Institution Country Purpose <strong>of</strong> <strong>the</strong> Visit<br />
Pr<strong>of</strong> J E Scott University <strong>of</strong> Manchester UK Lecture<br />
Pr<strong>of</strong> R Feldmann National Institutes <strong>of</strong> Health (NIH) USA Lecture<br />
Pr<strong>of</strong> H H Goebel University <strong>of</strong> Mainz Germany Lecture<br />
APPENDIX I-V<br />
Scientific journals available at <strong>the</strong> <strong>Department</strong><br />
No <strong>Name</strong> <strong>of</strong> Journal Version<br />
1. Science & Medicine paper<br />
123
SECTION I: APPENDIXES<br />
APPENDIX I-VI<br />
Publications <strong>of</strong> <strong>the</strong> <strong>Department</strong> members during 1996-2000<br />
MONOGRAPHS<br />
1. A. Aabloo. Studies <strong>of</strong> crystalline celluloses using potential energy calculations. Ph D <strong>the</strong>ses, 1994<br />
(supervisor R.-H. Mikelsaar)<br />
PAPERS IN INTERNATIONAL JOURNALS<br />
1. M. Väli, D. Lepik, I. Drikkit, V. Vassiljev. The characteristics <strong>of</strong> injuries in case <strong>of</strong> different car accidents.<br />
Medicina Legalis Baltika, 1997, 8, 34-38<br />
2. V. Valdes, R.-H. Mikelsaar, A. Truupõld. Die Entwicklung der Pathologie in Estland. Pathologe,<br />
1998, 19, 447-466<br />
3. P. Naaber, R.-H. Mikelsaar, S. Salminen, M. Mikelsaar. Bacterial translocation, intestinal micr<strong>of</strong>lora<br />
and morphological changes <strong>of</strong> intestinal mucosa in experimental models <strong>of</strong> Clostridium difficile infection.<br />
J.Med Microbiol, 1998, 47, 591-598<br />
4. E. Seppet, A. Kaasik, A. Minajeva, K. Paju, J. J. Ohisalu, R. Vetter. Mechanisms <strong>of</strong> thyroid hormone<br />
control over sensitivity and maximal contractile responsiveness to β-adrenergic agonists in<br />
atria. J. Mol. Cell. Biochem., 1998, 184, 419-426<br />
5. M. Uusküla, K. Lamp, M. Väli. An age-related difference in <strong>the</strong> ratio <strong>of</strong> sudden coronary death over<br />
acute myocardial infarction in Estonian males. Journal <strong>of</strong> Clinical Epidemiology, 1998, 51, (7), 577-<br />
580<br />
6. V. Vassiljev, A. Kalda, P. Pokk, M. Väli, A. Zharkovsky. The effects <strong>of</strong> nitric oxide synthase inhibitor<br />
7-nitroindazole on ethanol pharmacokinetics in rats after acute and chronic ethanol administration.<br />
Alcohol & Alcoholism, 1998, 33, 609-615<br />
7. V. Vassiljev, A. Kalda, P. Pokk, M. Väli, A. Zharkovsky. Nitric oxide synthase inhibitor 7nitroindazole<br />
attenuates <strong>the</strong> behavioural signs <strong>of</strong> ethanol withdrawal due to pharmacokinetic interaction.<br />
Medical Science Research, 1998,.26, 821-822<br />
8. A. Kalda, E. Eriste, V. Vassiljev, A. Zharkovsky. Medium transitory oxygen-glucose deprivation induced<br />
both apoptosis and necrosis in cerebella granule cells. Neuroscience Letters, 1997, 239, 1-4<br />
9. V. Vassiljev, A. Kalda, P. Pokk, M. Väli, A. Zharkovsky. Modified method for <strong>the</strong> induction <strong>of</strong> ethanol<br />
dependence in mice. Baltic Journal <strong>of</strong> Laboratory Animal Science, 1998, 8, 89-92<br />
10. M. Väli, D. Lepik, I. Drikkit, I. Mesila,V. Vassiljev. Sudden death cases <strong>of</strong> school-age children.<br />
Medicina Legalis Baltica, 1999, 11, 59-66<br />
11. M. Väli, V. Vassiljev, I. Drikkit, D. Lepik, A. Kalda, P. Pokk, A. Zarkovsky. Programmed cell death<br />
as phenomena in <strong>the</strong> CNS during ethanol withdrawal. Medicina Legalis Baltica, 1998, 9, 133 - 138<br />
12. M. Väli, I. Drikkit, D. Lepik, V. Vassiljev. Accidents in South-Estonia in 1993 - 1997, correlation <strong>of</strong><br />
accidents with abuse <strong>of</strong> alcohol. Medicina Legalis Baltica, 1998, 9, 125 – 132<br />
13. E. Raukas, R.-H. Mikelsaar. Are <strong>the</strong>re molecules <strong>of</strong> nucleoprotamine. Bioessays, 1999, 21 (5), 440-<br />
448<br />
14. A. Kaasik, A. Minajeva, E. De Sousa, R. Ventura-Clapier, V. Velsker. Nitric oxide inhibits cardiac<br />
energy production via inhibition <strong>of</strong> mitochondrial creatine kinase. FEBS Letters, 1999, 444 (1), 75-7<br />
15. E. De Sousa, V. Velsker, A. Minajeva, A. Kaasik, P. Mateo, E. Mayoux, J. Hoerter, X. Bigard, B.<br />
Serrurier, R. Ventura-Clapier. Subcellular creatine kinase alterations. Implications in heart failure.<br />
Circulation Research, 1999, 85 (1), 68-76<br />
16. I. Mesila. Mitotic activity in organs <strong>of</strong> rats affected by DMBA implants in <strong>the</strong> abdominal cavity. Papers<br />
on antropology VIII 1999, 127-45<br />
17. V. Vassiljev, M. Väli, P. Pokk. The effects <strong>of</strong> nitric oxide synthase inhibitors L-NAME and L-NOARG<br />
on <strong>the</strong> behavioural signs <strong>of</strong> ethanol withdrawal. Medical Science Research, 1999, 27 (6), 409-410<br />
18. A. Kaasik, V. Vassiljev, E. Põldoja, A. Kalda, A. Zharkovsky. Do nuclear condensation or fragmentation<br />
and DNA fragmentation reflect <strong>the</strong> mode <strong>of</strong> neuronal death. Neuroreport, 1999, 10 (9), 1937-<br />
1942<br />
19. M. Mikelsaar, E. Türi, M. Türi, I. Smidt, H. Annuk, R.-H. Mikelsaar. Interaction <strong>of</strong> Lactobacillus fermentum<br />
and Escherichia coli in giunea pig testes model. Microbial Ecology in Health and Disease,<br />
1999, 2, 114<br />
20. M. Mikelsaar, E. Türi, M. Türi, I. Smidt, H. Tamm, R.-H. Mikelsaar. Interaction <strong>of</strong> Lactobacillus fermentum<br />
and Escherichia coli in guinea pig testis model. Microecology and Therapy, 1999, 28, 319-<br />
326<br />
124
PATHOLOGICAL <strong>ANATOMY</strong> AND FORENSIC MEDICINE<br />
21. V. Vassiljev, I. Mesila, M. Väli, P. Pokk. The influence <strong>of</strong> <strong>the</strong> nitric oxide synthase inhibitor L-<br />
NOARG on <strong>the</strong> effects <strong>of</strong> ethanol in rats after acute ethanol administration. Pharmacology and<br />
Toxicology, 2000, 86, 63-67<br />
22. P. Pokk, V. Vassiljev, M. Väli. Small platform stress increases [3H]Ro 15-4513 binding in <strong>the</strong> cerebellum<br />
<strong>of</strong> mice. Fund. Clin. Pharmacol., 2000, 14, 487-491<br />
23. P. Pokk, V. Vassiljev, M. Väli. The effects <strong>of</strong> bacl<strong>of</strong>en on <strong>the</strong> locomotor activity <strong>of</strong> control and smallplatform<br />
stressed mice. Pharmacological Research, 2000, 42 (3), 235-237<br />
24. P. Pokk, V. Vassiljev, M. Väli. The influence <strong>of</strong> <strong>the</strong> nitric oxide synthase inhibitor L-NAME on <strong>the</strong><br />
effects <strong>of</strong> ethanol in rats after acute ethanol administration. Medical Science Research, 2000, 28,<br />
7-8<br />
25. M. Väli, T. Vaas, V. Vassiljev, H. Pallo, I. Drikkit. A case <strong>of</strong> death caused by dogs. Medicina Legalis<br />
Baltica, 2000, 12, 23-28<br />
26. A. Kalda, A. Kaasik, V. Vassiljev, P. Pokk, A. Zharkovsky. Neuroprotective action <strong>of</strong> group I metabotropic<br />
glutamate receptor agonists against oxygen-glucose deprivation-induced neuronal<br />
death. Brain Research, 2000, 852 (2), 370-373<br />
27. A. Kulla, A. Liigant, A. Piirsoo, G. Rippin, T. Asser. Tenascin expression and cells <strong>of</strong> monocyte<br />
lineage: relationship in human gliomas. Mod. Pathol. 2000, 13, 56-67<br />
28. A. Liigant, A. Kulla, T. Asser, A.-E. Kaasik. Epidemiology <strong>of</strong> Primary Central Nervous System Tumors<br />
in Estonia. Neuroepidemiology, 2000, 19, 300-311<br />
29. M. Ots, A. Kulla, M. Luman, V. Leiba, E. Ritz. Non-diabetic nodular glomerulosclerosis recurring in<br />
a renal graft. Nephrol Dialysis Transpl. 2000, 15, 2053-2056<br />
30. H. Kaarma, J. Peterson, R. Stamm, M. Lintsi, J. Kasmel, G. Veldre, E. Maiste. Application <strong>of</strong> anthropometric<br />
data in medicine, health promotion and physical education. Russian morphological<br />
newsletter. Moscow, 2000, 1-2, 296-297<br />
31. K. Lilleväli, A. Kulla, T. Örd. Comparative expression analysis <strong>of</strong> <strong>the</strong> genes encoding polypyrimidine<br />
tract binding protein (PTB) and its neural homologue (brPTB) in prenatal and postnatal mouse<br />
brain. Mechanisms <strong>of</strong> Development. 2001<br />
PAPERS IN ESTONIAN JOURNALS<br />
1. T. Truupõld, A. Truupõld. Tuberkuloosi patomorfoosist Tartu prosektuuri lahanguandmeil ajavahemikul<br />
1955-1994. Eesti Arst, 1997, 1, 25-29<br />
2. T. Truupõld, A. Truupõld. Tuberkuloos põhi-ja kaasnenud haigusena Tartu prosektuuri lahangumaterjalis<br />
ajavahemikul 1955-1994. Eesti Arst, 1997, 2, 123-128<br />
3. R.-H. Mikelsaar, A. Aabloo, T. Reintamm, E. Raukas. DNA pakendumine spermatosoidides – uus<br />
nukleoprotamiini mudel. Eesti Rohuteadlane, 1997, (lisa) 8, 36-37<br />
4. R.-H. Mikelsaar. 300 aastat sektsioonikursust ja patoanatoomiat Tartu Ülikoolis. Eesti Arst, 1998, 6,<br />
544-548<br />
5. R.-H. Mikelsaar. Fülo- ja ontogeneesi aspekte patoloogias. Ontogenees ja fülogenees. Schola<br />
bio<strong>the</strong>oretica XXIV, Tartu, OÜ Sulemees, 1998, 158-159<br />
6. H. Kaarma, J. Peterson, J. Kasmel, K. Saluvere, G. Veldre, L. Saluste, K. Loolaid. Naise kehastruktuuri<br />
seaduspärasused ja nende kasutamise võimalused terviseedenduses ja ravis. Eesti Arst,<br />
1998, 5, 420-422<br />
7. M. Punab, A. Kulla, H. Everaus. Ekstramedullaarse blastse kriisiga kroonilise müeloidse leukeemia<br />
juht. Eesti Arst, 1999, 3, 388-390<br />
8. R.-H. Mikelsaar. Geneetilis-konformatsiooniline mälu, selle defektid ja muutused. Schola bio<strong>the</strong>oretica<br />
XXV. Biosüsteemide mälu teooria. 1999, 32-33<br />
9. ngate<br />
verelipiidide näitajate seos kehaehitusega. Eesti Arst, 1999, 5, 388-390<br />
10. O. Uibo, R. Shor, M. Paal, A. Kulla, K. Metsküla. Tsöliaakia diagnoosimine aasta pärast insuliinsõltuva<br />
suhkurtõve avastamist. Haigusjuhu kirjeldus. Eesti Arst, 2000, 11, 690-693<br />
11. H. Kaarma, R. Stamm, G. Veldre, J. Kasmel. Possibilities for classification <strong>of</strong> anthropometric data<br />
<strong>of</strong> 16-18-year-old Tartu schoolgirls considering <strong>the</strong>ir age and constitutional peculiarities. Papers on<br />
Anthropology IX Tartu, 2000, 64-81<br />
12. J. Kasmel. About <strong>the</strong> student days <strong>of</strong> <strong>the</strong> Latvian-American anatomist and anthropologist Pr<strong>of</strong><br />
Jekabs Primanis in Yuryev (Tartu) in 1911-1913. Papers on Anthropology IX Tartu, 2000, 82-87<br />
13. J. Kasmel, T. Kasmel. Pr<strong>of</strong>essor Daniel Georg Balk – <strong>the</strong> first anthropology lecturer at <strong>the</strong> reopened<br />
University <strong>of</strong> Dorpat (Tartu) in 1802. Acta Medico-Historica Rigensia. Volumen V. Riga,<br />
2000, 103-107<br />
125
SECTION I: APPENDIXES<br />
TEXTBOOKS<br />
1. A. Truupõld. Patoloogilise anatoomia praktikum I. TÜ patoloogilise anatoomia ja kohtuarstiteaduse<br />
instituut, Tartu 1996<br />
2. A. Truupõld. Patoloogilise anatoomia praktikum II. TÜ patoloogilise anatoomia ja kohtuarstiteaduse<br />
instituut, Tartu 1996<br />
3. A. Truupõld. Practical Classes in Pathological Anatomy. University <strong>of</strong> Tartu, Institute <strong>of</strong> Pathological<br />
Anatomy and Forensic Medicine, Tartu 1997<br />
4. M. Väli, I. Drikkit, D. Lepik, V. Vassiljev. Vehicle traumas. 1998<br />
5. M. Väli, I. Drikkit, D. Lepik, V. Vassiljev, M. Talumäe. Mechanical injuries. 1999<br />
126
PATHOLOGICAL <strong>ANATOMY</strong> AND FORENSIC MEDICINE<br />
APPENDIX I-VII<br />
Academic and administrative personnel: <strong>Department</strong> <strong>of</strong> Pathological Anatomy and Forensic Medicine<br />
<strong>Name</strong> Title Load Area Gender Birth year Scientific degree Year <strong>of</strong> commencement Labour time (y)<br />
1. Raik-Hiio Mikelsaar Pr<strong>of</strong>essor 1,00 Pathological anatomy Male 1939 Ph.D, Dr.Sci 1989 16<br />
2. Ingrid Mesila Assistant 1,00 Pathological anatomy Female 1959 17<br />
3. Hannes Tamm Assistant 1,00 Pathological anatomy Male 1970 2<br />
4. Maret Murde Assistant (extraord.) 1,00 Pathological anatomy Female 1963<br />
5. Marika Väli Docent 1,00 Forensic medicine Female 1959 Cand.Sci 1989 8<br />
6. Daily Lepik Assistant 1,00 Forensic medicine Female 1962 14<br />
7. Ilona Drikkit Assistant 1,00 Forensic medicine Female 1968 6<br />
8. Aari Talve Sr. Technical staff 1,00 Female 1941 34<br />
9. Niina Puusaag Sr. Technical staff 1,00 Female 1956 6<br />
10. Marika Talumäe Sr. Technical staff 1,00 Female 1964 5<br />
1 Dr.Sci and Cand.Sci are degrees <strong>of</strong> <strong>the</strong> Former Soviet Union which correspond to a Dr.Med and Ph.D, respectively<br />
127
APPENDIX I-VIII<br />
Curriculum Vitae <strong>of</strong> <strong>the</strong> staff<br />
PATHOLOGICAL <strong>ANATOMY</strong> AND FORENSIC MEDICINE<br />
MIKELSAAR, RAIK-HIIO Date <strong>of</strong> birth: October 13, 1939 Gender: male Citizenship: Estonian Address:<br />
Jakobsoni 11-4, Tartu 51005 Educational history: 1957 – graduated Tartu 5. Secondary School (with<br />
golden medal), 1963 – graduated Medical Faculty <strong>of</strong> Tartu University (with commendation) Academic<br />
degrees (with year and university): 1968 – Cand Sci, Tartu University, 1989 – Dr Sci, Moscow University<br />
Employment and pr<strong>of</strong>essional experience: 1963-1975 – pathologist, Tartu Clinical Hospital,<br />
1975-1979 – senior research worker, Laboratory <strong>of</strong> Collagenoses, Tartu University, 1979-1983 – senior<br />
research worker, Laboratory <strong>of</strong> Genetics and Cytology, Tartu University, 1984-1997 – senior research<br />
worker, Laboratory <strong>of</strong> Molecular Modelling , Tartu University, 1997-1999 – docent, <strong>Department</strong><br />
<strong>of</strong> Pathological Anatomy and Forensic Medicine, Tartu University, 1999 – pr<strong>of</strong>essor, <strong>Department</strong> <strong>of</strong><br />
Pathological Anatomy and Forensic Medicine, Tartu University Administrative experience: 1975 –<br />
head <strong>of</strong> Laboratory <strong>of</strong> Collagenoses, Tartu University, 1984 – head <strong>of</strong> Laboratory <strong>of</strong> Molecular Modelling,<br />
Tartu University, 2000 – head <strong>of</strong> <strong>Department</strong> <strong>of</strong> Pathological Anatomy and Forensic Medicine,<br />
Tartu University Honours and awards: 1985 – memorial medal <strong>of</strong> K E von Baer, 1987 – premium <strong>of</strong><br />
Estonian Council <strong>of</strong> Ministers, 1989 – honorary diploma <strong>of</strong> World Cultural Council Membership in<br />
academic and scientific societies: International Society <strong>of</strong> Origin <strong>of</strong> Life , International Society <strong>of</strong><br />
Biochemistry, International Society <strong>of</strong> Crystallography, Estonian Society <strong>of</strong> Pathology, Estonian Society<br />
<strong>of</strong> Morphology, Estonian Association <strong>of</strong> Scientists Current research program and grants: Elucidation<br />
<strong>of</strong> <strong>the</strong> pathogenesis peculiarities and possibilities <strong>of</strong> treatment <strong>of</strong> <strong>the</strong> most important infection<br />
diseases in Estonia Supervision <strong>of</strong> dissertations: 1994 – Alvo Aabloo, Ph D Publications: 220<br />
Publications: monographs – 2, scientific articles in international journals – 31, o<strong>the</strong>r scientific articles<br />
– 82, conference <strong>the</strong>ses – 74, o<strong>the</strong>r publications (dissertations, patents) - 35<br />
VÄLI, MARIKA Date <strong>of</strong> birth: 03.10.1959 Gender: female Citizenship: Estonian Address: Kalda tee 8-<br />
35, Tartu, Estonia Educational history: 1977 graduated Tartu Secondary School No 5, 1983 graduated<br />
from <strong>the</strong> Faculty <strong>of</strong> Medicine <strong>of</strong> <strong>the</strong> University <strong>of</strong> Tartu Academic degrees (with year and university):<br />
docent, 1998, Chair <strong>of</strong> Forensic Medicine, University <strong>of</strong> Tartu Employment and pr<strong>of</strong>essional<br />
experience: 1983-1986 assistant <strong>of</strong> <strong>the</strong> Chair <strong>of</strong> Forensic Medicine <strong>of</strong> <strong>the</strong> University <strong>of</strong> Tartu, 1986-<br />
1995 Head <strong>of</strong> Viljandi <strong>Department</strong> <strong>of</strong> <strong>the</strong> Estonian Bureau <strong>of</strong> Forensic Medicine, since 1995 Head <strong>of</strong><br />
<strong>the</strong> Chair <strong>of</strong> Forensic Medicine <strong>of</strong> <strong>the</strong> University <strong>of</strong> Tartu Administrative experience: Head <strong>of</strong> Viljandi<br />
<strong>Department</strong> <strong>of</strong> <strong>the</strong> Estonian Bureau <strong>of</strong> Forensic Medicine, Head <strong>of</strong> <strong>the</strong> Chair <strong>of</strong> Forensic Medicine <strong>of</strong><br />
<strong>the</strong> University <strong>of</strong> Tartu, Chief Expert <strong>of</strong> <strong>the</strong> Estonian Bureau <strong>of</strong> Forensic Medicine, Vice-President <strong>of</strong><br />
<strong>the</strong> Baltic Medico-Legal Association Honours and awards: Membership in academic and scientific<br />
societies: member <strong>of</strong> <strong>the</strong> Estonian Association <strong>of</strong> Forensic Medicine, member <strong>of</strong> <strong>the</strong> Estonian Society<br />
<strong>of</strong> Pathologists Current research program and grants: 1.The consequences <strong>of</strong> chronic alcoholism -<br />
reasons <strong>of</strong> cell death (necrosis, apoptosis), working out <strong>the</strong> marker <strong>of</strong> chronic alcoholism in heavily<br />
drunken people, determing <strong>of</strong> CDT (carbohydrate-deficient-transferrin). 2. Investigation <strong>of</strong> reasons <strong>of</strong><br />
sudden death (especially cardiomyopathy and acute coronary insufficiency). Supervision <strong>of</strong> dissertations:<br />
supervisior <strong>of</strong> <strong>the</strong> postgraduate student Daily Lepik “Differentation <strong>of</strong> pistols Makarov, Glock<br />
and TT and estimation <strong>of</strong> <strong>the</strong> range <strong>of</strong> firing according to <strong>the</strong> damages caused by bullet and gunshot<br />
residues”since September 1999; supervisior <strong>of</strong> <strong>the</strong> postgraduate student Vitali Vassiljev “Molecular<br />
and pathomorphological changes in tissues after chronical ethanol consumption and <strong>the</strong>ir prevention”<br />
since September 1999. Publications: total 14, 11 <strong>of</strong> <strong>the</strong>m in international journals<br />
LEPIK, DAILY Date <strong>of</strong> birth: 15.05.1962 Gender: female Citizenship: Estonian Address: Vapramäe 7,<br />
50411 Tartu, Estonia Educational history: 1969 - 1980 Tartu Secondary School No 5, 1980 - 1986<br />
Faculty <strong>of</strong> Medicine <strong>of</strong> <strong>the</strong> University <strong>of</strong> Tartu Academic degrees (with year and university): Employment<br />
and pr<strong>of</strong>essional experience: 1980 - 1986 hospital attendant and operating sister in<br />
Maarjamõisa Hospital. Since1986 assistant <strong>of</strong> <strong>the</strong> Chair <strong>of</strong> Forensic Medicine <strong>of</strong> <strong>the</strong> <strong>Department</strong> <strong>of</strong><br />
Pathological Anatomy and Forensic Medicine, University <strong>of</strong> Tartu, 1987 - 1994 forensic expert <strong>of</strong> Tartu<br />
<strong>Department</strong> <strong>of</strong> Estonian Bureau <strong>of</strong> Forensic Medicine Administrative experience: Honours and<br />
awards: Membership in academic and scientific societies: member <strong>of</strong> Estonian Association <strong>of</strong> Forensic<br />
Medicine, member <strong>of</strong> <strong>the</strong> Estonian Society <strong>of</strong> Pathologists. Current research program and<br />
grants: 1. Molecular and pathomorphological mechanisms <strong>of</strong> alcoholism related brain and heart damage<br />
and its pathomorphological prevention. 2. The consequences <strong>of</strong> chronic abuse <strong>of</strong> alcohol - reasons<br />
<strong>of</strong> cell death (necrosis, apoptosis), working out <strong>the</strong> marker <strong>of</strong> chronic alcoholism in heavily<br />
drunken people, determing <strong>of</strong> CDT (Carbohydrate-Deficient-Transferrin). Supervision <strong>of</strong> dissertations:<br />
Publications: 9<br />
129
SECTION I: APPENDIXES<br />
DRIKKIT, ILONA Date <strong>of</strong> birth: 20.04.1968 Gender: female Citizenship: Estonian Address: Tähe 1-<br />
17, 51010, Tartu, Estonia Educational history: 1986 graduated <strong>the</strong> Secondary School No 7 <strong>of</strong> Tartu;<br />
1986-1992 studied in <strong>the</strong> Faculty <strong>of</strong> Medicine <strong>of</strong> <strong>the</strong> University <strong>of</strong> Tartu; 1992-1994 post-graduate<br />
training <strong>of</strong> general medicine Academic degrees (with year and university): Employment and pr<strong>of</strong>essional<br />
experience: From 1994 assistant <strong>of</strong> <strong>the</strong> Chair <strong>of</strong> Forensic Medicine <strong>of</strong> <strong>the</strong> University <strong>of</strong> Tartu;<br />
from 1995 forensic pathologist <strong>of</strong> <strong>the</strong> South-Estonian <strong>Department</strong> <strong>of</strong> <strong>the</strong> Bureau <strong>of</strong> Forensic Medicine<br />
<strong>of</strong> Estonia Administrative experience: Honours and awards: Membership in academic and scientific<br />
societies: Member <strong>of</strong> Estonian Association <strong>of</strong> Forensic Medicine Current research program<br />
and grants: 1. The consequences <strong>of</strong> chronic alcoholism - reasons <strong>of</strong> cell death (necrosis, apoptosis),<br />
working out <strong>the</strong> marker <strong>of</strong> chronic alcoholism in heavily drunken people, determing <strong>of</strong> CDT (carbohydrate-deficient-transferrin).<br />
2. Epidemiology <strong>of</strong> traumatic brain injuries in Estonia. 3.Causes <strong>of</strong> violent<br />
death in Estonia. Supervision <strong>of</strong> dissertations: Publications: 8<br />
MESILA, INGRID Date <strong>of</strong> birth: 03.03.1959, Tartu Gender: female Citizenship: Estonian Address:<br />
Männi 12, Tartu 50605, Estonia Educational history: medical higher education, graduated from <strong>the</strong><br />
University <strong>of</strong> Tartu in 1983 Academic degrees (with year and university): - Employment and pr<strong>of</strong>essional<br />
experience: 1983-1994 elder laboratory assistant, since 15. March 1994 assistant in <strong>the</strong> Institute<br />
<strong>of</strong> Pathological Anatomy and Forensic Medicine <strong>of</strong> <strong>the</strong> University <strong>of</strong> Tartu Administrative experience:<br />
outside service – president <strong>of</strong> choir Honours and awards: - Membership in academic and scientific<br />
societies: member <strong>of</strong> Estonian Society <strong>of</strong> Pathologists and Estonian Society <strong>of</strong> Morphologists<br />
Current research program and grants: Reactive changes with DMBA containing intraabdominal implants.<br />
Mitotic activity in different organs <strong>of</strong> rats affected by cancerogenic stuff containing implants in<br />
abdominal cavity. Helicobacter pylory and gastritis with different reactive changes Supervision <strong>of</strong><br />
dissertations: - Publications: toge<strong>the</strong>r 20 publications<br />
TAMM, HANNES Date <strong>of</strong> birth: 25-th <strong>of</strong> February 1970, Tallinn Gender: male Citizenship: Estonian<br />
Address: Jaama street 179-22, Tartu, Estonia Educational history: medical higher education,<br />
graduated from <strong>the</strong> University <strong>of</strong> Tartu, Medical Faculty in 1997. General practitioner since 1998 Academic<br />
degrees (with year and university): - Employment and pr<strong>of</strong>essional experience: 1997-1998<br />
elder laboratory assistant in <strong>the</strong> <strong>Department</strong> <strong>of</strong> Anatomy, since 31 July 1998 assistant in <strong>the</strong> <strong>Department</strong><br />
<strong>of</strong> <strong>the</strong> Pathological Anatomy and Forensic Medicine. From June, 2000 resident <strong>of</strong> pathological<br />
anatomy Administrative experience: - Honours and awards: - Membership in academic and scientific<br />
societies: member <strong>of</strong> Estonian Society <strong>of</strong> Pathologists, and <strong>of</strong> Estonian Junior Doctor’s Association<br />
Current research program and grants: Antagonistic activity <strong>of</strong> lactobacilli against salmonella<br />
infection in mouse model Supervision <strong>of</strong> dissertations: - Publications: toge<strong>the</strong>r 3 publications<br />
MURDE, MARET Date <strong>of</strong> birth: 29.09.1963 Gender: female Citizenship: Estonian Address: Staadioni<br />
44, 51008 Tartu, Estonia Educational history: 1988 – graduated <strong>the</strong> medical Faculty, Tartu University<br />
Academic degrees (with year and university): - Employment and pr<strong>of</strong>essional experience:<br />
1992 – 2000 – a paediatrician, Outpatient <strong>Department</strong> <strong>of</strong> Paediatrics, Tartu University, second category<br />
<strong>of</strong> paediatrics. February – may, 1993 – a lecturer, <strong>Department</strong> <strong>of</strong> Hygiene, Tartu University. 2000<br />
– an extraordinary assistant, <strong>Department</strong> <strong>of</strong> <strong>the</strong> Pathological Anatomy and Forensic Medicine, Tartu<br />
University Administrative experience: - Honours and awards: - Membership in academic and scientific<br />
societies: - Current research program and grants: Elucidation <strong>of</strong> <strong>the</strong> pathogenesis peculiarities<br />
and possibilities <strong>of</strong> treatment <strong>of</strong> <strong>the</strong> most important infection diseases in Estonia Supervision<br />
<strong>of</strong> dissertations: - Publications: -<br />
130
PUBLIC HEALTH<br />
<strong>Name</strong> <strong>of</strong> <strong>the</strong> <strong>Department</strong>: <strong>Department</strong> <strong>of</strong> Public Health<br />
Head <strong>of</strong> <strong>the</strong> <strong>Department</strong>:<br />
The <strong>Department</strong> has 5 Chairs:<br />
Pr<strong>of</strong>essor Raul-Allan Kiivet<br />
<strong>Name</strong> <strong>of</strong> <strong>the</strong> Chair: Head <strong>of</strong> <strong>the</strong> Chair:<br />
Health Promotion Docent Maarike Harro<br />
Epidemiology and biostatistics Senior Assistant Katrin Lang<br />
Environmental and Occupational Health Pr<strong>of</strong>essor Astrid Saava<br />
Health Care Management Pr<strong>of</strong>essor Raul-Allan Kiivet<br />
Health Economics Docent Kersti Meiesaar<br />
Courses to undergraduate students <strong>of</strong> medicine.<br />
Main courses Medical students Dentistry Nursing science<br />
Code Year Credits Code Year Credits Code Year Credits<br />
Health<br />
Promotion<br />
Epidemiology &<br />
biostatistics<br />
ARTH<br />
04.011<br />
ARTH<br />
03.006<br />
Environmental & ARTH<br />
Occupational<br />
Health<br />
01.045<br />
Health Care<br />
Management<br />
Health<br />
Economics<br />
ARTH<br />
02.006<br />
ARTH<br />
05.001<br />
2 4 CR ARTH<br />
04.011<br />
2 3 CR ARTH<br />
03.006<br />
3 3 CR ARTH<br />
01.044<br />
5 1,5 CR ARTH<br />
02.004<br />
5 1,5 CR ARTH<br />
05.002<br />
I. CONTENT OF THE TEACHING<br />
2 4 CR<br />
2 3 CR ARTH<br />
03.008<br />
2 2 CR<br />
5 1,5 CR<br />
5 1,5 CR ARTH<br />
05.007<br />
2 2 CR<br />
2 2 CR<br />
1. Describe shortly <strong>the</strong> main study and student evaluation methods applied at<br />
<strong>the</strong> department.<br />
The main study methods used to teach public health disciplines are seminars,<br />
group work and practical exercises. Lectures account for 20 to 30% <strong>of</strong> <strong>the</strong> direct<br />
teaching time <strong>of</strong> 24 hours per 1 credit, according to <strong>the</strong> discipline. The rest<br />
<strong>of</strong> time (16 hours per 1 credit) <strong>the</strong> students should prepare for <strong>the</strong> seminars,<br />
write projects, solve practical exercises and study course literature. The main<br />
student evaluation method at <strong>the</strong> end <strong>of</strong> course is a written exam (test with<br />
questions/answers and open questions - situation exercises). In all public<br />
health disciplines <strong>the</strong> presentation by students on <strong>the</strong> results <strong>of</strong> <strong>the</strong>ir homework<br />
is a prerequisite for passing <strong>the</strong> course. This homework is presented ei<strong>the</strong>r<br />
in <strong>the</strong> form <strong>of</strong> a project (in health promotion), essay (environmental health)<br />
or a critical analysis <strong>of</strong> scientific papers (health economics and health care<br />
management).<br />
131
SECTION I: SELF-EVALUATION<br />
2. How have <strong>the</strong> aims and objectives described in <strong>the</strong> curriculum changed<br />
during <strong>the</strong> past five years?<br />
During <strong>the</strong> last five years <strong>the</strong> proportion <strong>of</strong> public health disciplines in <strong>the</strong> curriculum<br />
<strong>of</strong> medical students has increased from 4% to 6,5% and its content<br />
was reformed. Since 1996 new disciplines – health promotion and health economics<br />
– were introduced and <strong>the</strong> content <strong>of</strong> <strong>the</strong> rest <strong>of</strong> courses has been<br />
radically changed. As well, new staff was recruited to <strong>the</strong> <strong>Department</strong> since<br />
1996, under <strong>the</strong> World Bank Estonia Health Project. Thus, during <strong>the</strong> last<br />
years <strong>the</strong> new courses were in constant development and this process has not<br />
yet completed.<br />
3. Describe <strong>the</strong> strengths and weaknesses <strong>of</strong> <strong>the</strong> teaching in your department.<br />
Strengths<br />
• We use guest lectures from o<strong>the</strong>r Faculties <strong>of</strong> <strong>the</strong> University (Phychology<br />
and Sociology etc) and highly qualified pr<strong>of</strong>essionals (University Clinics,<br />
Ministry <strong>of</strong> Social Affairs, Central Sick Fund etc) in order to provide students<br />
with experience directly from <strong>the</strong> field.<br />
• The staff is multidisciplinary. Despite <strong>the</strong> fact, that most <strong>of</strong> <strong>the</strong> staff are<br />
MD’s, <strong>the</strong> lecturers in health economy have diploma and scientific degree in<br />
Economics, and <strong>the</strong> future head <strong>of</strong> <strong>the</strong> Chair <strong>of</strong> Biostatistics has a diploma<br />
and scientific degree in Ma<strong>the</strong>matics.<br />
• In addition to lectures, teaching is mainly carried out in small groups (up to<br />
20 students) which makes learning more active for <strong>the</strong> students and provides<br />
immediate feedback for <strong>the</strong> lecturers.<br />
• Possibility to use technical aids (data projection, video, computer) and deliver<br />
written materials.<br />
• The staff is open-minded and ready to fur<strong>the</strong>r develop <strong>the</strong> content <strong>of</strong><br />
teaching according to <strong>the</strong> increase in <strong>the</strong>ir own experience and to <strong>the</strong> feedback<br />
given by <strong>the</strong> students.<br />
• Good international contacts with a variety <strong>of</strong> partner institutions.<br />
Weaknesses<br />
• The staff is young and not yet very productive in research. Thus <strong>the</strong> postgraduate<br />
students do not gain all <strong>the</strong> necessary guidance and support.<br />
• Shortage <strong>of</strong> text-books and literature in native language make learning difficult<br />
to students who are not fluent in English.<br />
• Few contacts and support from pr<strong>of</strong>essional organisations in public health<br />
in Estonia.<br />
4. Describe <strong>the</strong> innovations in your teaching.<br />
132<br />
On postgraduate level new curricula <strong>of</strong> Master <strong>of</strong> Public Health and Master <strong>of</strong><br />
Sciences in Public Health were developed in 1999-2000 and <strong>the</strong> first group <strong>of</strong>
PUBLIC HEALTH<br />
students started in September 2000. This is <strong>the</strong> first time public health specialists<br />
will be trained in Estonia since 1940.<br />
5. <strong>Name</strong> <strong>the</strong> factors which most disturb teaching (excluding financial resources).<br />
• Many <strong>of</strong> <strong>the</strong> staff lack personal pr<strong>of</strong>essional experience, which can make<br />
<strong>the</strong>ir message to <strong>the</strong> students sometimes too <strong>the</strong>oretical.<br />
• The structure and role <strong>of</strong> public health services has not been solved in Estonia,<br />
along with problems in manpower planning <strong>of</strong> public health specialists.<br />
• Much <strong>of</strong> energy and time <strong>of</strong> <strong>the</strong> staff is spent on various consulatncies and<br />
developmental activities on national (governmental) level. This provides<br />
contacts, experience and thus opportunities for fur<strong>the</strong>r development, but<br />
competes with <strong>the</strong> main objective – teaching.<br />
• The disciplines <strong>of</strong> public health are traditionally not perceived to be <strong>of</strong> relevance<br />
in order to become a physician and thus <strong>the</strong> enthusiasm <strong>of</strong> students<br />
is generally low.<br />
II. EVALUATION OF TEACHING<br />
6. How is <strong>the</strong> quality <strong>of</strong> <strong>the</strong> teaching in your department evaluated? How are<br />
<strong>the</strong> content and <strong>the</strong> modes <strong>of</strong> <strong>the</strong> teaching changed on <strong>the</strong> basis <strong>of</strong> <strong>the</strong><br />
evaluation?<br />
During last years, after completion <strong>of</strong> a course it has been usually evaluated<br />
by <strong>the</strong> students on <strong>the</strong> basis <strong>of</strong> questionnaires, developed by <strong>the</strong> different<br />
chairs <strong>of</strong> <strong>the</strong> <strong>Department</strong>. This has provided some feedback for <strong>the</strong> tutors on<br />
how to improve <strong>the</strong> content and presentation <strong>of</strong> <strong>the</strong> course. The heads <strong>of</strong><br />
chairs routinely visit <strong>the</strong> seminars and lectures given by junior staff and guest<br />
lecturers in order to upgrade <strong>the</strong> content and mode <strong>of</strong> teaching <strong>of</strong> different tutors.<br />
In May 1999, a Peer-Review team from ASPHER (Association <strong>of</strong> Schools <strong>of</strong><br />
Public Health in European Region) <strong>of</strong> 3 University Pr<strong>of</strong>essors <strong>of</strong> Public Health<br />
visited <strong>the</strong> <strong>Department</strong> for three days and draw up a comprehensive report,<br />
which is presented in full on <strong>the</strong> Web-page <strong>of</strong> <strong>the</strong> <strong>Department</strong><br />
(http://www.dph.ut.ee). In addition to <strong>the</strong>ir overall positive conclusions, <strong>the</strong><br />
team provided a number <strong>of</strong> realistic and critical suggestions for improvement<br />
<strong>of</strong> teaching and fur<strong>the</strong>r development <strong>of</strong> <strong>the</strong> <strong>Department</strong>, many <strong>of</strong> which have<br />
been followed.<br />
III. PEDAGOGIC TRAINING OF STAFF<br />
7. How many <strong>of</strong> <strong>the</strong> teachers have received pedagogic training?<br />
Approximately half <strong>of</strong> staff has attended formal courses <strong>of</strong> pedagogic training<br />
<strong>of</strong> 2-4 weeks <strong>of</strong> duration. This implies to <strong>the</strong> junior staff, who attended <strong>the</strong>se<br />
courses during <strong>the</strong>ir Master <strong>of</strong> Public Health studies abroad. The older staff<br />
has not gained formal pedagogic training.<br />
133
SECTION I: SELF-EVALUATION<br />
8. Is <strong>the</strong>re a need for fur<strong>the</strong>r pedagogic training?<br />
Yes, <strong>the</strong>re is a urgent need for this type <strong>of</strong> training, as <strong>the</strong> junior staff has received<br />
pedagogic training before <strong>the</strong>y had any teaching experience <strong>the</strong>mselves,<br />
and <strong>the</strong> senior staff has no pedagogic training.<br />
IV. TEACHING RESOURCES<br />
9. Is <strong>the</strong>re a need for rearrangement <strong>of</strong> <strong>the</strong> teaching resources in your department?<br />
If so, how should this be done?<br />
Rearrangement <strong>of</strong> teaching resources inside <strong>the</strong> <strong>Department</strong> is not felt to be<br />
necessary at <strong>the</strong> moment.<br />
V. COORDINATION OF THE TEACHING<br />
10. How is <strong>the</strong> teaching co-ordinated with o<strong>the</strong>r departments? Indicate <strong>the</strong> departments<br />
that are closest to your department.<br />
Interaction between chairs inside <strong>the</strong> <strong>Department</strong> as well as with o<strong>the</strong>r <strong>Department</strong>s<br />
<strong>of</strong> <strong>the</strong> Faculty <strong>of</strong> Medicine should be improved in order to increase<br />
coherence in teaching. So far <strong>the</strong> main partners in teaching have been from<br />
<strong>the</strong> <strong>Department</strong> <strong>of</strong> Family Medicine. This co-operation has been improved over<br />
<strong>the</strong> years but is not yet as good as it should.<br />
VI. FUTURE PLANS<br />
11. Future plans to improve <strong>the</strong> teaching given by <strong>the</strong> department.<br />
In addition to <strong>the</strong> points made above, on undergraduate level we plan to reorganize<br />
<strong>the</strong> present 5 separate courses into a more interdisciplinary course <strong>of</strong><br />
public health. For example, at <strong>the</strong> moment, <strong>the</strong> 2 nd year students receive basic<br />
knowledge in epidemiology before <strong>the</strong>y have seen any patient or disease and<br />
naturally <strong>the</strong> discipline seems too <strong>the</strong>oretical for <strong>the</strong>m. We plan to transfer<br />
some <strong>of</strong> this course to <strong>the</strong> 5 th year in order to teach clinical epidemiology and<br />
basics <strong>of</strong> research design. Instead, some <strong>of</strong> <strong>the</strong> content <strong>of</strong> <strong>the</strong> course <strong>of</strong> health<br />
care management (presently on 5 th year), namely <strong>the</strong> organisation <strong>of</strong> health<br />
care and main legislation in Estonia will be presented to <strong>the</strong> 2 nd year students<br />
in order <strong>the</strong>y would have a better picture <strong>of</strong> <strong>the</strong> scene when <strong>the</strong>y enter clinical<br />
studies.<br />
134<br />
The o<strong>the</strong>r main goal for <strong>the</strong> staff is to write textbooks and handbooks in <strong>the</strong>ir<br />
respective disciplines to be used both at undergraduate and postgraduate<br />
level as well as in continuous education.
PUBLIC HEALTH<br />
Public Health: resource evaluation<br />
1. Study materials<br />
- How many study books are published in your institution during last five years? 39<br />
- Do you have separate room as library in your place? Yes No<br />
- Could students borrow study books from your institution? Yes No<br />
- Do you have on-line published study materials for students? Yes No<br />
- WWW address: http://www.dph.ut.ee<br />
- Does University library has enough modern books in your speciality?<br />
Completely enough Enough Scarcely Absolutely scarcely No<br />
2. Amount and size <strong>of</strong> study rooms<br />
- Rooms used by Your institution only: 20 rooms with area <strong>of</strong> 770 m 2<br />
- Rooms shared with ano<strong>the</strong>r institution: rooms with area <strong>of</strong> m 2<br />
- Do You have enough space for study process by Your opinion?<br />
Completely enough Enough Scarce Absolutely scarcely<br />
- How <strong>the</strong> scarce <strong>of</strong> space should be handled or changed?<br />
New building Change to smaller student groups Better logistics<br />
O<strong>the</strong>r way (describe shortly)<br />
3. Current situation <strong>of</strong> study rooms<br />
- There has been repairments in last years (except Biomedicum)<br />
- How are <strong>the</strong> study rooms lightened?<br />
Very good Good Some darkness Absolutely dark for study<br />
- Evaluation <strong>of</strong> general conditions: Very good Good Satisfactory Bad<br />
4. Your institution has<br />
a) 2 (how many?) auditorium(s) for workshops/seminars with 20 places, equipped with<br />
Blackboard<br />
White board & markers<br />
Screen<br />
Overhead projector<br />
Data projector<br />
Slide projector<br />
b) 2 (how many?) laboratories for practicals with 20 places, equipped with<br />
Blackboard<br />
White board and markers<br />
Screen<br />
Overhead projector<br />
Data projector<br />
Slide projection kit<br />
TV/Video projection set<br />
Computer<br />
Internet connection<br />
TV/Video projection kit<br />
Computer<br />
Internet connection<br />
5. Working rooms for teaching staff and postgraduate students:<br />
- Number <strong>of</strong> teaching staff 14<br />
- Number <strong>of</strong> rooms for staff 14<br />
- Number <strong>of</strong> individual working places 24, among <strong>the</strong>m with computers 34<br />
- Number <strong>of</strong> postgraduate students is 25<br />
- How many individual working places <strong>the</strong>y have? 6<br />
- How many computers <strong>the</strong>y have? 6<br />
6. O<strong>the</strong>r comments on resource topic (max 250 letters):<br />
135
SECTION I: APPENDIXES<br />
APPENDIX I-I<br />
Visits <strong>of</strong> <strong>the</strong> department members to o<strong>the</strong>r institutions abroad during 1996-2000<br />
Year Researcher/Lectures Institution Country Purpose Duration<br />
1996 Alar Sepp. Assistant 6th Biennal Coinference <strong>of</strong> ESHMS Hungary Conference 1 week<br />
1996 Astrid Saava, Pr<strong>of</strong>essor University <strong>of</strong> Medicine aand pharmacy<br />
medical school, Cluj-Napoca<br />
Romania Conference 1 week<br />
1996 Astrid Saava, Pr<strong>of</strong>essor Universitu <strong>of</strong> Helsingi and Turku Finland Research 2 week<br />
1996 Astrid Saava, Pr<strong>of</strong>essor Association <strong>of</strong> School <strong>of</strong> Public Health<br />
in <strong>the</strong> European Region<br />
Ne<strong>the</strong>rlands Congress 1 week<br />
1996 Astrid Saava, Pr<strong>of</strong>essor Institute <strong>of</strong> Occupational Medicine and<br />
Environmental health WHO Collaborating<br />
Centre<br />
Poland Congress 2 week<br />
1996 Diva Eensoo, Research Nordic Institute for Advanced Training Finland Training 1 week<br />
Associate<br />
in Occupational Health<br />
1996 Eda Merisalu, Docent Nordic Institute for Advanced Training<br />
in Occupational Health<br />
Finland Training 1 week<br />
1996 Eda Merisalu, Docent Nordic Institute for Advanced Training<br />
in Occupational Health<br />
Finland Training 1 week<br />
1996 Kaja Põlluste, Senior as- University <strong>of</strong> Utrecht, Ne<strong>the</strong>rlands Ne<strong>the</strong>rlands Training 2 week<br />
sistant<br />
School <strong>of</strong> Public Health<br />
1996 Katrin Lang, Senior assistant<br />
University <strong>of</strong> Nottingham UK Research 2 week<br />
1996 Maarike Harro, Docent The 1996 International Pre-Olympia<br />
Scientific Congress<br />
USA Conference 1 week<br />
1996 Marina Kaarna, Assistant University <strong>of</strong> Utrecht, Ne<strong>the</strong>rlands<br />
School <strong>of</strong> Public Health<br />
Ne<strong>the</strong>rlands Training 2 week<br />
1996 Marina Kaarna, Sr assis- Nordic Institute for Advanced Training Finland Training 1 week<br />
tant<br />
in Occupational Health<br />
1996 Raul-Allan Kiivet, Pr<strong>of</strong>essor<br />
Stockholm School <strong>of</strong> Public Health Sweden Training 2 week<br />
1996 Raul-Allan Kiivet, Pr<strong>of</strong>essor<br />
Stockholm School <strong>of</strong> Public Health Sweden Training 2 week<br />
1997 Alar Sepp, Assistant Marina Congress Center Finland Conference 1 week<br />
1997 Alar Sepp, Assistant ESHMS Summer school Ne<strong>the</strong>rlands Training 2 week<br />
1997 Alar Sepp, Assistant University <strong>of</strong> Turku Finland Research 1 week<br />
1997 Argo Soon, Sr assistant Medical University <strong>of</strong> Lübeck Germany Research 1 week<br />
1997 Argo Soon, Sr assistant NIVA Finland Training 1 week<br />
1997 Argo Soon, Sr assistant Health effects <strong>of</strong> physical and mental<br />
work loads<br />
Island Training 1 week<br />
1997 Argo Soon, Sr assistant 32nd Graduate Summer Session in<br />
Epidemiology<br />
U.S.A Training 2 week<br />
1997 Astrid Saava, Pr<strong>of</strong>essor EUROTEX Education Course Lihuania Training 1 week<br />
1997 Astrid Saava, Pr<strong>of</strong>essor Environment and Health Training<br />
Course<br />
Lithuania Training 1 week<br />
1997 Astrid Saava, Pr<strong>of</strong>essor Central Eastern European Conference<br />
on Epidemiology and Environmental<br />
Safety<br />
Latvia Conference 1 week<br />
1997 Astrid Siilbek, Assistant Brimhealth Foundation Of Public Health Latvia Training 2 week<br />
1997 Diva Eensoo, Research 10th World Conference on Tobacco or China Conference 1week<br />
Associate<br />
Health<br />
1997 Eda Merisalu, Docent Kaunas Medical Academy Lithuania Training 2 week<br />
1997 Eda Merisalu, Docent International Congress <strong>of</strong> Stress: Stress Budapest<br />
and Life<br />
Conference 1 week<br />
1997 Eda Merisalu, Docent Health effects <strong>of</strong> physical and mental<br />
work loads<br />
Island Training 1 week<br />
1997 Kaja Põlluste, Sr assistant School <strong>of</strong> Public Health CMUJ (I) Poland Training 4 week<br />
1997 Katrin Lang, Sr assistant School <strong>of</strong> Public Health CMUJ (I) Poland Training 4 week<br />
1997 Katrin Lang, Sr assistant University <strong>of</strong> Navarra Spain Conference 1 week<br />
136
PUBLIC HEALTH<br />
1997 Katrin Lang, Sr assistant International course on principles <strong>of</strong><br />
epidemiologic rezearch<br />
Ne<strong>the</strong>rlands Training 1 week<br />
1997 Katrin Lang, Sr assistant Nordic Summer School in Methods <strong>of</strong><br />
Infectiour Disease Epidemiology<br />
Denmark Training 2 week<br />
1997 Kersti Meiesaar, Docent University <strong>of</strong> Kuopio and Helsinki Finland Research 2 week<br />
1997 Kersti Meiesaar, Docent School <strong>of</strong> Public Health CMUJ (I) Poland Training 4 week<br />
1997 Kersti Meiesaar, Docent European Healthcare Management Association<br />
Annual Conference<br />
Ne<strong>the</strong>rlands Conference 1 week<br />
1997 Kersti Pärna, Sr assistant 10th World Conference on Tobacco or<br />
Health<br />
China Conference 1 week<br />
1997 Maarike Harro, Docent University <strong>of</strong> Uppsala Sweden Research 1 month<br />
1997 Maarike Harro,Docent XIXth International Symposium <strong>of</strong> Pediatric<br />
Work<br />
Great Britain Conference 1 week<br />
1997 Marina Kaarna, Assistant School <strong>of</strong> Public Health CMUJ (I) Poland Training 4 week<br />
1997 Marina Kaarna, Assistant 7th Summer Training Course on Health<br />
Promotion and Research<br />
Italy Training 2 week<br />
1997 Marina Kaarna, Assistant Foundation <strong>of</strong> Public Health , Part 2 Sweden Training 2 week<br />
1998 Argo Soon, Sr assistant NIVA Finland Training 1 week<br />
1998 Argo Soon, Sr assistant 9th European Training Consortium in<br />
Public Health and Health Promotion:<br />
UK Training 2 week<br />
1998 Argo Soon, Sr assistant Institut <strong>of</strong> Occupational Health Finland Research 1 month<br />
1998 Argo Soon, Sr assistant Fifth Praque Summer School Czech Rep Training 2 week<br />
1998 Argo Soon, Sr assistant Fifth Praque Summer School Czech Rep Training 2 week<br />
1998 Argo Soon, Sr assistant Lybeck Medical School Germany Research 1 month<br />
1998 Astrid Saava, Pr<strong>of</strong>essor Ministry <strong>of</strong> Public Health Bulgary Congress 1 week<br />
1998 Astrid Saava, Pr<strong>of</strong>essor 25th International Congress an Arts and USA<br />
Community"<br />
Conference 2 week<br />
1998 Astrid Saava, Pr<strong>of</strong>essor University <strong>of</strong> Uppsala Sweden Conference 1 week<br />
1998 Astrid Saava, Pr<strong>of</strong>essor XX ASPHER Annual Conference Quality<br />
in Public Health<br />
Italy Conference 1 week<br />
1998 Astrid Saava, Pr<strong>of</strong>essor ILSI Workshop Germany Conference 1 week<br />
1998 Astrid Siilbek, Assistant Fifth Praque Summer School Czech Rep Training 2 week<br />
1998 Diva Eensoo, Research The First European Conference on <strong>the</strong> Ne<strong>the</strong>rlands Conference 1 week<br />
Associate<br />
Promotion<br />
1998 Diva Eensoo, Research<br />
Associate<br />
University <strong>of</strong> Uppsala Research Research 1 month<br />
1998 Eda Merisalu, Docent Second World Congress on Stress Australia Congress 1 week<br />
1998 Eda Merisalu, Docent University <strong>of</strong> Stavanger Norway Research 1 week<br />
1998 Katrin Lang, Sr assistant London School <strong>of</strong> Hygiene and Tropical<br />
Medicine<br />
UK Research 1 week<br />
1998 Kersti Pärna, Sr assistant Fifth Praque Summer School Poland Training 2 week<br />
1998 Kersti Pärna, Sr assistant Conference "Tobacco and Woman" France Conference 1 week<br />
1998 Kersti Pärna, Sr assistant Cardiff International Arena UK Training 2 week<br />
1998 Maarike Harro, Docent University <strong>of</strong> Uppsala Finland Research 2 week<br />
1998 Maarike Harro, Docent "CINP" XXI congress UK Conference 2 week<br />
1998 Maarike Harro, Docent Second World Congress on Stress Australia Congress 1 week<br />
1998 Maarike Harro, Docent University <strong>of</strong> Bristol UK Training 1 week<br />
1998 Marina Kaarna, Assistant BRIMHEALTH Course Primary Health<br />
Care<br />
Russian Training 2 week<br />
1998 Marina Kaarna, Assistant Course on Primary Care <strong>of</strong> NSPH Russian Training 2 week<br />
1998 Marina Kaarna, Assistant Qualitative Research Methods in Public<br />
Health<br />
Sweden Training 2 week<br />
1998 Raul-Allan Kiivet, Pr<strong>of</strong>essor<br />
Hradec University Czech Rep Conference 1 week<br />
1999 Alar Sepp, Assistant University <strong>of</strong> Tampere Finland Research 1 week<br />
1999 Alar Sepp, Assistant University <strong>of</strong> Tampere Finland Research 1 week<br />
1999 Argo Soon, Sr assistant 8th International Conference on Indoor<br />
Air Quality and Climate”<br />
UK Conference 1 week<br />
137
SECTION I: APPENDIXES<br />
1999 Argo Soon, Sr assistant NIVA Denmark training 1 week<br />
1999 Argo Soon, Sr assistant Neurobehavioral Methods and Effects<br />
in Occupational and Environmetal<br />
Health<br />
Sweden Conference 1 week<br />
1999 Argo Soon, Sr assistant Kaunas Medical Academy Lithuania Conference 1 week<br />
1999 Astrid Saava, Pr<strong>of</strong>essor University <strong>of</strong> Kuopio Finland Lectures 1 week<br />
1999 Astrid Saava, Pr<strong>of</strong>essor International Symposium: New Frontiers<br />
in Public Health<br />
Lithuania Conference 1 week<br />
1999 Astrid Siilbek, Assistant Ninth Annual Public Health Forum UK Training 2 week<br />
1999 Eda Merisalu, Docent University <strong>of</strong> Stavanger Norway Research 1 week<br />
1999 Kaja Põlluste, Senior assistant<br />
Palair de l'Europe France Conference 1 week<br />
1999 Kersti Meiesaar, Docent 8th Seminar on Health Economics Finland Lectures 1 week<br />
1999 Kersti Meiesaar, Docent 20th Nordic Health Economists' Study<br />
Group Meeting<br />
Island Conference 1 week<br />
1999 Kersti Pärna, Sr assistant 2nd European Conference on Tobacco<br />
or Health "Smoke free 21st Century"<br />
Spain Conference 1 week<br />
1999 Marina Kaarna, Assistant Palair de l'Europe France Conference 1 week<br />
1999 Raul-Allan Kiivet, Pr<strong>of</strong>essor<br />
ASPHER Spain Conference 1 week<br />
1999 Raul-Allan Kiivet, Pr<strong>of</strong>essor<br />
Helarew University <strong>of</strong> Jerusalem Jeruusalem Conference 1 week<br />
2000 Argo Soon, Sr assistant 26th International Congress on Occupational<br />
Health”<br />
Singapur Congress 1 week<br />
2000 Argo Soon, Sr assistant International Conference “Healthy<br />
Buildings 2000”,<br />
Finland Conference 1 week<br />
2000 Eda Merisalu, Docent 3nd World Congress on Stress Ireland Congress 1 week<br />
2000 Kersti Pärna, Sr assistant University <strong>of</strong> Helsinki Finland Research 1 week<br />
2000 Maarike Harro, Docent University <strong>of</strong> Exeter Visit UK Research 2 week<br />
2000 Maarike Harro, Docent University <strong>of</strong> Tampere Finland Training 2 week<br />
2000 Maarike Harro, Docent XXII nd CINP Congress Belgium Congress 1 week<br />
2000 Maarike Harro, Docent XXVII Congress <strong>of</strong> Psychology Sweden Congress 1 week<br />
2000 Maarike Harro, Docent University <strong>of</strong> Uppsala Sweden Research 4 week<br />
2000 Maarike Harro, Docent University <strong>of</strong> Tampere Finland Conference 1 week<br />
2000 Raul-Allan Kiivet, Pr<strong>of</strong>es- VII world Conference on Clinical Phar- Florence Conference 1 week<br />
sormacology<br />
& Therapeutics<br />
2001 Maarike Harro National Institute <strong>of</strong> Public Health Finland Training 1 week<br />
2001 Maarike Harro National Institute <strong>of</strong> Public Health Finland Training 1 week<br />
2001 Maarike Harro University <strong>of</strong> Uppsala Sweden Research 2 week<br />
APPENDIX I-II<br />
Postgraduate students at <strong>the</strong> <strong>Department</strong> having studied abroad during 1996-2000<br />
Year <strong>Name</strong> Institution Contry Duration<br />
1996 Argo Soon Joseph H. and Belle R. Braun Hebrew University Israel 1 year<br />
1996 Kersti Pärna University <strong>of</strong> Kuopio Finland 1 year<br />
1997 Kaja Põlluste BRIMHEALTH Sweden 3 years<br />
1999 Ene Indermitte University <strong>of</strong> Kuopio Finland 1 year<br />
1999 Katrin Lang University <strong>of</strong> London School <strong>of</strong> Hygiene and Tropical Medicine UK 2 years<br />
1999 Agris Koppel BRIMHEALTH Sweden 2 week<br />
1999 Katrin Sihver BRIMHEALTH Sweden 2 week<br />
1999 Jaana Alep Ospedate Bambino GESU, IRCCS Italy 1 week<br />
2000 Agris Koppel BRIMHEALTH Sweden 2 week<br />
2000 Katrin Sihver BRIMHEALTH Sweden 2 week<br />
2000 Liis Nirk BRIMHEALTH Sweden 2 week<br />
138
APPENDIX I-III<br />
PUBLIC HEALTH<br />
Co-operation with institutions from o<strong>the</strong>r countries and participation in international<br />
research projects during 1996-2000<br />
Contact person Institution Country Aim <strong>of</strong> <strong>the</strong> collaboration<br />
Argo Soon University <strong>of</strong> Uppsala Sweden Indoor air quality and health<br />
Argo Soon Finnish Institute <strong>of</strong> Occupational Finland Development <strong>of</strong> occupational<br />
Health<br />
health services<br />
Kersti Pärna University <strong>of</strong> Helsinki Finland Research<br />
Katrin Lang European Centre on Health <strong>of</strong><br />
Societies in Transition and London<br />
School <strong>of</strong> Hygiene and<br />
Tropical Medicine, University <strong>of</strong><br />
London<br />
England Research<br />
Pr<strong>of</strong>. A.Saava University <strong>of</strong> Turku Finland Create an interactive CD-ROM<br />
on environmental health<br />
Pr<strong>of</strong>. A.Saava University <strong>of</strong> Kuopio Finland Advanced public health research<br />
Pr<strong>of</strong>. A.Saava Nordic School <strong>of</strong> Public Health Sweden BRIMHEALTH<br />
Docent Kersti Meiesaar University <strong>of</strong> Kuopio Finland Research<br />
Docent Kersti Meiesaar Ne<strong>the</strong>rlands Institute <strong>of</strong> Primary<br />
Health Care<br />
Ne<strong>the</strong>rlands Research<br />
Docent Kersti Meiesaar Care Institute <strong>of</strong> Health Economics<br />
Canada Research<br />
Ass. Alar Sepp University <strong>of</strong> Tampere Finland Research and teaching<br />
Ass. Alar Sepp Medizinische Universität zu<br />
Lübeck<br />
Germany Teaching and research<br />
Ass. Alar Sepp The Hebrew University <strong>of</strong> Jerusalem<br />
Israel Research and teaching<br />
Sr assistant Kaja Põlluste Nordic School <strong>of</strong> Public Health Sweden Research and teaching<br />
Docent Maarike Harro IYHS /International Youth UK, Denmark, Research<br />
Hearth Study/<br />
Sweden, Portugal<br />
Pr<strong>of</strong> Raul-Allan Kiivet EU Copernicus Joint Research Spain, Sweden, Research<br />
Project ERB - IC15 - CT98-0340 Hungary<br />
APPENDIX I-IV<br />
Visiting lecturers at <strong>the</strong> <strong>Department</strong> during 1996-2000<br />
Visitor Institution Country Purpose<br />
Pr<strong>of</strong> David Leon University <strong>of</strong> London UK Teaching<br />
Katrin Saluvere Ministry <strong>of</strong> Social Affairs EST Teaching<br />
Maris Jesse Central Sick Fund EST Teaching<br />
Arvi Vask Ministry <strong>of</strong> Social Affairs EST Teaching<br />
Piret Laur Ministry <strong>of</strong> Social Affairs EST Teaching<br />
Kersti Reinsalu Ministry <strong>of</strong> Social Affairs EST Teaching<br />
Pr<strong>of</strong> Antonio Campos Institute <strong>of</strong> Public Administration for Portugal Portugal Lecture<br />
Dr Hernan Fuenzalida International Consultant on Social Security Reforms USA Lecture<br />
Matti Rajala European Commission EU Lecture<br />
Pr<strong>of</strong> Lembit Rägo State Agency <strong>of</strong> Medicines EST Lecture<br />
Dr Antje Reumann de Fernandez University <strong>of</strong> Bonn Germany Lecture<br />
139
SECTION I: APPENDIXES<br />
APPENDIX I-V<br />
Scientific journals available at <strong>the</strong> <strong>Department</strong><br />
No <strong>Name</strong> <strong>of</strong> Journal Version<br />
1. American Journal <strong>of</strong> Epidemiology paper<br />
2. American Journal <strong>of</strong> Public Health paper<br />
3. Applied Occupational and Environmental Hygiene paper<br />
4. Health Policy paper<br />
5. Health Promotion International paper<br />
6. Indoor Air paper<br />
7. International Journal for Quality in Health Care paper<br />
8. International Journal Health Planning & Management paper<br />
9. Journal <strong>of</strong> Health Economics paper<br />
10. Medical History paper<br />
11. Public Health paper<br />
12. World Health Statistics Annual paper<br />
140
APPENDIX I-V<br />
Publications <strong>of</strong> <strong>the</strong> <strong>Department</strong> members during 1996-2000<br />
MONOGRAPHS<br />
PUBLIC HEALTH<br />
1. Harro M, Riddoch C. Measurement <strong>of</strong> physical activity in children. Oxford University Press, 2000.<br />
2. Lang K. Death Certification, Coding and Registration in Estonia.<br />
http://www.Ishtml.ac.uk/centres/ecohost/projects.htm#death-estonia, 2000 pg 46<br />
68. Lang K. Cancer in Estonia: Registration, Rates and Public Health. London School <strong>of</strong> Hygiene and<br />
Tropicxal Medicine, London, 2000, pg 60 /Degree <strong>of</strong> doctor <strong>of</strong> Medical Sciences/<br />
69. Põlluste K. Developing a client-oriented health care service in <strong>the</strong> Children’s Hospital <strong>of</strong> <strong>the</strong> University<br />
<strong>of</strong> Tartu. Nordic School <strong>of</strong> Public Health, Göteborg, 2000 pg 60 /Degree <strong>of</strong> Master <strong>of</strong> Public<br />
Health/<br />
70. Eensoo D. Association <strong>of</strong> physical activity with mental health and personality. University <strong>of</strong> Tartu,<br />
2000 pg 68 /Degree <strong>of</strong> Master <strong>of</strong> Public Health/<br />
71. Kiivet R-A. Drug utilization studies as supgort to decisions in drug policy in Estonia. Stockholm<br />
1999 pg 46 /Degree <strong>of</strong> doctor <strong>of</strong> Medical Sciences/<br />
72. Pihl E. Cardiovascular risk factors in middle-aged former athletes. University <strong>of</strong> Tartu, 1999 pg 97<br />
/Degree <strong>of</strong> doctor <strong>of</strong> Medical Sciences/<br />
73. Innos K. Epidemiological Resources in Estonia: Data sources, <strong>the</strong>ir quality and <strong>the</strong> feasibility <strong>of</strong> cohort<br />
studies. University <strong>of</strong> Tartu , 1999 pg 101 /Degree <strong>of</strong> doctor <strong>of</strong> Medical Sciences/<br />
74. Tusti E. Tick-borne encephalitis in Estonia. University <strong>of</strong> Kuopio, Finland, 1999 pg 49 /Degree <strong>of</strong><br />
Master <strong>of</strong> Public Health/<br />
75. Merisalu E. Eesti õpetajate tööstress ja tervis. Tartu 1999 pg 1-36<br />
76. Merisalu E. Elva õpetajate hinnangud koolikeskkonnale. In:Mehilane L. "Mis on koolilapsel muret",<br />
1999<br />
77. Saava A. Peipsi järve sanitaar-hügieeniline seisund. (toim. Pihu E, Raukas A). Tallinn1999 pg 84-<br />
89<br />
78. Soon A. Sick Building Syndrome in Hadassah Hospital Office Workers. Joseph H. and Belle R.<br />
Braun Hebrew University – Hadassah School <strong>of</strong> Public Health and Community Medicine, Jerusalem,<br />
Israel, 1997 pg 90 /Degree <strong>of</strong> Master <strong>of</strong> Public Health/<br />
79. Pärna Kersti. Smoking and Associated Factors Among Adolescents in Tallinn (Estonia). University<br />
<strong>of</strong> Kuopio, Finland, 1997 pg 60 /Degree <strong>of</strong> Master <strong>of</strong> Public Health/<br />
80. Kuus K. The economic impact <strong>of</strong> cancer in Estonia. University <strong>of</strong> Tartu, 1997 pg 56<br />
81. Siilbek A. Perinatal Mortality in Estonmia in Comparision to Surrounding European Countries. The<br />
Ne<strong>the</strong>rlands School <strong>of</strong> Public Health (NSPH), The Ne<strong>the</strong>rlands, 1997 pg 46 /Degree <strong>of</strong> Master <strong>of</strong><br />
Public Health/<br />
82. Sallo M. Stdies on habitual physical activity and aerobic fitness in 4 to 10 years old children, University<br />
<strong>of</strong> Tartu, 1997 pg 81/Degree <strong>of</strong> doctor <strong>of</strong> Medical Sciences/<br />
PAPERS IN INTERNATIONAL JOURNALS<br />
1. Sallo M, Viru A. Aerobic capacity and physical activity in 4 to 10 year-old children. Biology <strong>of</strong> Sport.<br />
1996; 13: 211-219.<br />
2. Viru A, Loko J, Volver A, Laaneots L, Sallo M, Smirnova T, Karelson K. Alterations in foundations<br />
for motor development in children and adolescents. Coaching and Sport Science Journal. 1996; 4:<br />
11-19<br />
3. Kaarma H, Tapfer H, Veldre G, Thetl<strong>of</strong>f M, Saluste L, Peterson J. Some principles to be considered<br />
when using young womens anthropometric data. Biology <strong>of</strong> Sport. 1996; 13:127 –135.<br />
4. Senkpiel K, Soon A, Ohgke H. Untersuchung zur mikrobiziden Wirkung von ausgewählten kommerziell<br />
erhältlichen Antischimmelpilz. Präparaten für den häuslichen Gebrauch. GesundheitsIngenieur.<br />
München R.Oldenbourg Verlag. 1996; 117; 2: 86-92.<br />
5. Marandi T, Dahl ML, Kiivet RA, Rägo L, Sjöqvist F. Debrisoquin and mephenytoin hydroxylation<br />
phenotypes and CYP2D6 genotypes in an Estonian population. Pharmacology and Toxicology.<br />
1996; 78: 303-307<br />
6. Kaasik T, Hörte L.G, Andersson R. Injury in Estonia: An Estonian-Swedish Comparative Study. Ki<br />
Green Raport 324. Karolinska Institutet, <strong>Department</strong> <strong>of</strong> Public Health Sciences, Division <strong>of</strong> Social<br />
Medicine, Sundbyberg. 1996; 29 pg.<br />
7. Ristimäe T, Thetl<strong>of</strong>f M, Teesalu R. Heart rate variability in patients with mild heart failure secondary<br />
to coronary artery disease: comparison <strong>of</strong> patients with and without prior myocardial infraction.<br />
Journal Electrocardiol, 1996;29:162-167<br />
141
SECTION I: APPENDIXES<br />
8. Harro J, Sallo M, Rimm H, Jaanimägi N, Päevloo A, Villa I. Does <strong>the</strong> personality <strong>of</strong> parents influence<br />
<strong>the</strong> physical activity <strong>of</strong> <strong>the</strong>ir children?.- Children and Exercise XIX. Promoting health and wellbeing.<br />
London: E & FN SPON, 1997, 157-162.<br />
9. Harro M. Validation <strong>of</strong> a Questionnaire to Assess Physical Activity <strong>of</strong> Children Ages 4-8 Year.- Research<br />
Quarterly for Exercise and Sport, 1997, 68, 4, 259-268.<br />
10. Kõiv L, Merisalu E, Zilmer K, Tomberg T, Kaasik AE. Changes <strong>of</strong> sympathoadrenal and hypothalamo-pituitary-adrenocortical<br />
system in patients with head injury.- Acta Neurologica Scandinavica.<br />
Munksgaard: 1997, 96, 52-58.<br />
11. Kaasik AT, Jürimäe T. Influence <strong>of</strong> four-week examination session stress and hypokinesia on serum<br />
lipoprotein pattern in students.- Canadian Journal <strong>of</strong> Cardiology, 1997, 13S, 320B.<br />
12. Marandi T, Dahl ML Rägo L, Kiivet RA, Sjöqvist F. Debrisoquine and S-mephenytoin hydroxylation<br />
polymorphisms in a Russian population living in Estonia.- European Journal <strong>of</strong> Clinical Pharmacology,<br />
1997, 53, 257-260.<br />
13. Pihl E, Jürimäe T, Kaasik T. Effect <strong>of</strong> physical activity on cardiovascular health in 18-25-year-old<br />
university students.- Acta Medica Baltica. Riga: 1997, 4, 1, 84-87.<br />
14. Pihl E, Jürimäe T, Kaasik T. Coronary heart disease risk factors physical activity and fitness in<br />
middle-aged female former athletes in comparison with young athletes.- Sportorvosi szemle: Hungarian<br />
Review <strong>of</strong> Sports Medicine, 1997, 2, 69-78.<br />
15. Sallo M, Silla R. Physical activity with moderate to vigorous intensity in 4 to 10 years old children.-<br />
Pediatric Exercise Science, 1997, 9, 1, 44-54.<br />
16. Sallo M, Harro J, Viru A. Moderate to vigorous physical activities in preadolescent children.- Children<br />
and Exercise XIX. Promotion health and well-being. London: E &FN SPON, 1997, 151-156.<br />
17. Kaasik T, Andersson R, Hörte L-G. The effects <strong>of</strong> political and economic transitions on health and<br />
safety in Estonia: An Estonian-Swedish comparative study. Social Science and Medicine 1998; 47<br />
(10):1589-1599.<br />
18. Kiivet RA, Bergman U, Rootslane L, Rägo L, Sjöqvist F. Drug use in 1994-1995: a follow-up from<br />
1989 and comparsion with two Nordic countries. European Journal <strong>of</strong> Clinical Pharmacology 1998,<br />
54:119-124.<br />
19. Kiivet RA, Bergman U, Sjöstedt S, Sjöqvist F. Ulcer surgery in Estonia a consequence <strong>of</strong> drug delay?<br />
The Lancet 1998; 351: 146<br />
20. Pihl E, Jürimäe T. Kaasik T. Coronary heart disease risk factors in middle-aged former top-level<br />
athletes. Scandinavian J <strong>of</strong> Medicine & Science in Sport, 1998; 8:229-235<br />
21. Meiesaar K, Kopgel A, Metsa A, Lember M. Evaluation <strong>of</strong> primary health care reform. IN: Terveystaloustiede<br />
5/1999. Toim. Mai Nordberg, Pekka Rissanen & Satu Kerpgilä. Helsinki: Stakes,<br />
1999; 54 - 59.<br />
22. Rimm H, Harro M, Karelson K, Grauberg M, Viru A, Harro J. State mood and self-efficacy in relation<br />
to physical activity and fitness in young healthy men. Acta Psychiatrica Belgica. 1999; 99: 16-<br />
22.<br />
23. Viru A, Loko J, Harro M, Volver A, Laaneots L, Viru M. Critical periods in <strong>the</strong> development <strong>of</strong> performance<br />
capacity during childhood and adolescence. European Journal <strong>of</strong> Physical Education.<br />
1999; 4: 75-117.<br />
24. Harro J, Häidkind R, Harro M, Modiri AR, Gillberg PG, Pähkla R, Matto V, Oreland L. Chronic mild<br />
unpredictable stress after noradrenergic denervation: attenuation <strong>of</strong> behavioural and biochemical<br />
effects <strong>of</strong> DSP-4 treatment. European Neuropsychopharmacology. 1999; 10 (1): 5-16.<br />
25. Harro J, Pähkla R, Modiri AR, Harro M, Kask A, Oreland L. Dose-dependent effects <strong>of</strong> noradrenergic<br />
denervation by DSP- 4 treatment on forced swimming and ß- adrenoceptor binding in <strong>the</strong> rat.<br />
Journal <strong>of</strong> Neural Transmission. 1999; 160: 619-629.<br />
26. Harro J, Rimm H, Harro M, Karelson K, Viru A. Association <strong>of</strong> depressiveness with blunted growth<br />
hormone response to maximal physical exercise in young healthy men. Psychoneuroendocrinology.<br />
1999; 24(5): 505-517.<br />
27. Pähkla R, Lambert J, Ansko P, Winstanley P, Davies PDO, Kiivet RA. Comparative bioavailability<br />
<strong>of</strong> three different preparations <strong>of</strong> rifampicin. Journal <strong>of</strong> Clinical Pharmacy and Therapeutics. 1999;<br />
24: 219-225.<br />
28. Soon A, Kähkönen E. Volatile Organic Compounds in Tartu Office Buildings. ATLA-Alternatives to<br />
Laboratory Animals. 1999; 27: 413-415.<br />
29. Pärna K. Passive smoking among adolescents in Estonia. Human & Experimenta Toxicology.<br />
1999; 18: 229-232<br />
30. Hokka P, Palosuo H, Zhuravleva I, Pärna K, Mussalo-Rauhamaa, Lakomova. Anxiety about environmental<br />
hazards among teenagers in Helsinki, Moscow and Tallinn. The Science <strong>of</strong> <strong>the</strong> Total<br />
Environment. 1999; 234: 95-107.<br />
31. Soon A. The Sick Building Syndrome and Type <strong>of</strong> Ventilation in Estonia Office Buildings.<br />
Absctracts in <strong>the</strong> 8 th International Conference on Edinburg. 1999, 1: 141-146.<br />
142
PUBLIC HEALTH<br />
32. Innos K, Rahu M. , Rahu K. Feasibility <strong>of</strong> cohort studies in Estonia. Occupational Environmental<br />
Medicine, 1999; 56: 499-502<br />
33. Saava A, Kiivet R. Health care reforms in Estonia. In: Health sector reform in Central and Eastern<br />
Europe. FIOSSER, 1999: 97-105<br />
34. Põlluste K, Kalda R, Lember M. Primary Health Care System in Transistion: The Patient’s experience.<br />
Int J Qual Health Care, 2000;12:503-509<br />
35. Saava A. History <strong>of</strong> Public Health research in Estonia. Eur J Public Health, 2000; 10:164-167.<br />
36. LLerena A, Kiivet RA, Dahl ML, Sanchez Vega J, Rootslane L, Wettermark B. Psychotropic drug<br />
use in non-psychiatric departments <strong>of</strong> three European university hospitals. Nordic Journal <strong>of</strong><br />
Psychiatry, 2000; 54: 61-65<br />
37. Saava A. Public health research in Estonia. European Journal <strong>of</strong> Public Health. 2000, Vol. 10, Nr.<br />
3, Sept., 164-167.<br />
38. Soon, A, “The Sick Building Syndrome and Type <strong>of</strong> Ventilation in Estonian Office Buildings”, The<br />
8 th International Conference on Indoor Air Quality and Climate, 8-13 August 1999, Edinburgh,<br />
Scotland, Proceedings Vol.1 pg. 141-146<br />
39. Soon, A, “What causes Sick Building Syndrome – sick workroom or sick dwelling?”, The 5 th international<br />
conference “Healthy Building 2000” August 6-10, 2000, Espoo, Finland, Vol.1 pg. 83-88<br />
40. Soon, A, “Mucous Membrane Irritation Symptoms among Hadassah Hospital Office Workers”, Neurotoxicology,<br />
2000, Vol 21, pg. 882-883<br />
41. Eensoo D, Harro J, Harro M, Rimm J, Viru A. Depressiveness, anxiety, perceived stress, and selfefficancy<br />
in midle-aged men with different engagement in physical activity. Medicina Dello Sport,<br />
2000;1:69-74<br />
42. Soon A. What causes Sick Building Syndrome – sick workroom or sick dwelling. Helsingi SIY Indoor<br />
Air Information OY, 2000:1, 83-88<br />
43. Gibis B, Artiles J, Corabian P, Meiesaar K, Koppel A, Jacobs P, Serrano P, Menon D. Apglication<br />
<strong>of</strong> SWOT analysis in <strong>the</strong> development <strong>of</strong> health techonology assessment program. Journal Health<br />
Policy, 2000 pg 16.<br />
PAPERS IN ESTONIAN JOURNALS<br />
1. Grauberg M, Sallo M, Karelson K. Maksimaalne hapnikutarbimine meesüliõpilastel. Sporditeooria<br />
ja treeninguõpetuse instistuudi teadus- ja õpgemetoodiliste tööde kogumik, 1996;4: 25-30.<br />
83. Põlluste K. Biomeetria õpetamine Arstiteaduskonnas. Eesti Statistikaselts, Teabevihik. 1995; 5:52-<br />
57.<br />
84. Sallo M, Kull M, Volver A. Viru A. Problems <strong>of</strong> habitual physical activity in children and adolescents.<br />
Acta Academiae Olympicae Estoniae, 1996; 3:140-150<br />
85. Koll K. Eetilised probleemid moodsas epidemioloogias. Eesti Arst, 1996;4:325-329<br />
86. Grünberg H, Thetl<strong>of</strong>f M. Laste adipoossus, hindamise kriteeriumid, esinemissagedus, füüsiline<br />
areng ja lipiidide ainevahetushäired. Eesti Arst, 1996; 2:109-111<br />
87. Jürimäe T, Pihl E. Kehalise kasvatuse õpetajate tervislik seisund. Eesti Arst, 1996;2:115-118.<br />
88. Kiivet R.A., Rootslane L Vendla K. Ravimkasutuse muutus aastail 1989 ja 1994. Eesti Arst,<br />
1996;4:291-295<br />
89. Kaastik T, Hörte LG, Andersson R. Vigastused surmapõhjustena Eestis ja Rootsis.- Eesti Arst,<br />
1997, 2, 143-147.<br />
90. Eensoo D, Sallo M, Pärna K. Eesti koooliõpilaste võimalikud tervist mõjutavad tegurid.- Eesti Rohuteadlane,<br />
1997, Lisa, 9.<br />
91. Grünberg H, Thetl<strong>of</strong>f M, Pubertal stages <strong>of</strong> Estonian children.- Papers on anthropology VII. Tartu:<br />
1997, 84-89.<br />
92. Järvelaid M, Loolaid V, Kaarma H, Thetl<strong>of</strong>f M, Loolaid K. The sexual maturation and anthropometric<br />
characteristics <strong>of</strong> 15- to 18 years-old schoolgirls.- Papers on anthropology VII. Tartu: 1997,<br />
142-150.<br />
93. Kiivet R. Eesti tervishoiu kvaliteedipoliitika.- Eesti Tervishoiureformi konverents: Toimetised. Tallinn:1997,<br />
35-38.<br />
94. Kuus K, Siilbek A. Tuberkuloosi epidemioloogia ja kontrolli programmid tänapäeval.- Tuberkuloos<br />
ja perearstid. Tartu: 1997, 31-37.<br />
95. Meiesaar K, Soodla V, Metsa A. Võrdsusest Eesti tervishoius.- Eesti Rohuteadlane, 1997, Lisa,<br />
33-34.<br />
96. Meiesaar K. Tuberkuloosi majanduslikud aspektid.- Tuberkuloos ja perearstid. Tartu: 1997, 38-<br />
47.<br />
97. Meiesaar K, Metsa A. Rahvavoogude analüüs tervishoius.- Arvestuse ja maksunduse aktuaalsed<br />
probleemid. Tallinn: 1997, 122-128.<br />
143
SECTION I: APPENDIXES<br />
98. Põlluste K. Eesti elanikkonna tervis.- Väljakutse tervishoiuteenustele: Eesti tervishoiureformi konverents.<br />
Toimetised. Tallinn: 1997, 14-16.<br />
99. Rootslane L, Hinrikus T, Kiivet R,A. Valuvaigistite kasutamine TÜ Kliinikumi Maarjamõisa haiglas<br />
aastatel 1992 ja 1994.- Eesti Rohuteadlane, 1997, 1, 3-7.<br />
100. Sepp A, Sepp H. Tartumaa tervishoiulistest oludest 1930.a. alguses (dr. Mihkel Kase väitekirja<br />
järgi).- 75 aastat Eesti ülikooli Tartus. Tartu: TÜK, 1997, 179-186 (Tartu Ülikooli Ajaloo Küsimusi<br />
XXIX köide)<br />
101. Soon A. Ruumiõhu sündroom Jeruusalemma Hadassah’ Kliinikute kontorit öötajatel.- Eesti Rohuteadlane,<br />
Lisa, 64-65.<br />
102. Pärna K, Saava A. Tartu linna kooliõpilaste arvamus oma elukeskkonnast ja terviseriskidest.- Tervisekaitse<br />
1995, Tallinn, 1996, 101-107.<br />
103. Raud S, Paris D, Lepik A, Saava A, Eensoo D, Pärna K. Erakaevude seisund Tartu linnas.-<br />
Tervisekaitse 1995, Tallinn, 1996, 95-101.<br />
104. Saava A. Hügieeni õpetamine Tartu ülikoolis läbi aegade.- 75 aastat Eesti Ülikooli Tartus. Tartu:<br />
TÜK, 1997, 187-196, (Tartu Ülikooli ajaloo küsimusi XXIX)<br />
105. Thetl<strong>of</strong>f M. Eesti Antropomeetriaregistri loomise eesmärgid ja tulevikuplaanid.- Meditsiinistatistika<br />
ja -registrid, Tartu: Eesti Statistikaselts, 1997, 17-20, (Teabevihik 9/1997)<br />
106. Ilves P, Thetl<strong>of</strong>f M, Talvik T. Aju verevoolu kiirus ajalistel vastsündinutel esimesel elunädalal.-<br />
Eesti Arst, Tallinn: Perioodika, 1997, 4, 296-299<br />
107. Kaasik T, Kuus K, Thetl<strong>of</strong>f M, Uring R. Üliõpilaste tervis- eesti haritlaskonna tervise alus.- Haridus,<br />
1997, 6, 55-59.<br />
108. Sepp A. Eesti arstiteaduse ajaloost.- Eesti Arstide Liidu Teataja 4.04.1997, 1-8.<br />
109. Sepp A. The History <strong>of</strong> Medicine in Tartu.- Eesti Arstide Liidu Teataja 4.04.1997, 9-16.<br />
110. Eensoo D, Pärna K. Mida arvavad kooliõpilased oma elukeskkonnast?.- Keskkonnatehnika,<br />
1997,1, 11.<br />
111. Innos K, Rahu M, Rahu K. Rahvastikuandmete kvaliteet epidemioloogilistes uuringutes. Eesti Arst<br />
1998;(6):483-487.<br />
112. Saava A, Laursoo K, Künnap P Uued nõuded joogivee kvaliteedile. Eesti Arst, 1998, Lisa (Rahva<br />
tervisekaitse Eestis), lk. 531-534.<br />
113. Kaasik T. Vigastuste preventsioon kui rahvatervise oluline ülesanne. Eesti Arst: Rahva Tervisekaitse<br />
Eestis, 1998: 494-498.<br />
114. Kõiv L, Merisalu E, Kaasik A-E. Peaaju trauma ja humoraalse homöostaasi muutused. Eesti Arst,<br />
1998, 3, 238-246.<br />
115. Lang K, Meiesaar K, Danilovits M, Sillastu H, Siilbek A. Tuberkuloos kui tõsine rahvatervise<br />
probleem Eestis. Eesti Arst 1998;(lisa: Rahva tervisekaitse Eestis):512-516.<br />
116. Saava A. Health hazards due to drinking water in Estonia. Proc. Latvian Acad. Sci., Section B,<br />
Vol. 52 (1998), Supglement, p. 54-58.<br />
117. Soon, A, Ruumiõhu sündroom. Eesti Arst (lisa: Rahva tervisekaitse Eestis):1998, 537-541.<br />
118. Uring R, Thetl<strong>of</strong>f M, Lang K, Kaasik T. Üliõpilaste tervis – Eesti haritlaskonna tervise alus II. Haridus<br />
1998;(5):53-57.<br />
119. Sepp A. ENSV – TRÜ – EÜE. Eesti Üliõpilaste Ehitusmalev oma ajastu laps.Tartu Ülikooli ajaloo<br />
küsimusi XXX; (Tartu Ülikool 1970-1988);Tartu Ülikooli Kirjastus; 1998:134-140<br />
120. Merisalu E, Thetl<strong>of</strong>f M, Saava A. Eesti Üldhariduskoolide õpetajate hinnangud koolikeskkonnale.<br />
Tervisekaitse 1997, 1999, 33-39.<br />
121. Raud S, Lepik A, Pärna K, Eensoo D, Saava A. Tartu Ihaste linnaosa kaevude seisund. Tervisekaitse<br />
1996, Tallinn 1998.<br />
122. Meiesaar K, Metsa A. Country Case Study on <strong>the</strong> Effects <strong>of</strong> Remuneration Incentives on Provider<br />
Practice (Estonia). Tartu, 1998.<br />
123. Kaarna M, Kutsar K, Malbe R, Mehilane L, Merisalu E, Mitt K, Põlluste K, Russak S, Saava A,<br />
Trei T Eesti rahva tervis. Tartu, 1998, 56 lk.<br />
124. Kaarna M, Kutsar K, Malbe R, Mehilane L, Merisalu E, Mitt K, Põlluste K, Russak S, Saava A,<br />
Trei T. Public Health in Estonia. Tartu, 1998, 56 lk.<br />
125. Kalda R, Põlluste K, Lember M. Eesti elanikkonna hinnang esmatasandi tervishoius aset leidnud<br />
muudatustele. Eesti Arst, 1999;3:269-273<br />
126. Soon A, Kähkönen E, Ruut J, Saarinen L, Tupgurainen M. Indoor Air Quality in Tartu Office Buildings.<br />
Eesti Töötervishoid, 1999, lisa 5-9<br />
127. Meiesaar K. Tervise ökonoomika ja tervishoiuökonoomika. Eesti Arst, 2000;12: 743-746<br />
128. Põlluste K. Kaarna M, Thetl<strong>of</strong>f M, Vahula V, Sule U. Töötajate tööga rahulolu uuring Pärnu Haiglas.<br />
Eesti Arst, 2000; 5: 261-266<br />
129. Põlluste K. Kaarna M, Thetl<strong>of</strong>f M, Seppik M. Haiglaraviga rahulolu kujundavad tegurid Pärnu Haigla<br />
patsientide hinnangul. Eesti Arst; 2000, 11: 658-663<br />
130. Põlluste K. Tervishoiuasutuste akresditeerimine. Perearst; 200, 1;3-5<br />
144
SUBMITTED PAPERS<br />
PUBLIC HEALTH<br />
1. Gibis B, Artiles J, Corabian P, Meiesaar K, Kopgel A, Jacobs P, Serrano P, Menon D. Apglication<br />
<strong>of</strong> SWOT analysis in <strong>the</strong> development <strong>of</strong> health technology assessment program. Edmonton, 2000,<br />
16 p. Journal Health Policy (submitted)<br />
2. Kiivet RA, Kaur I, Lang A, Aaviksoo A, Nirk L. Cost <strong>of</strong> asthma treatment in Estonia. European<br />
Journal <strong>of</strong> Public Health, 2000 (manuscript 8T1019 accepted for publication)<br />
TEXTBOOK AND MANUALS<br />
1. R.Lepnurm, K.Mitt, K.Põlluste. Tervishoiusüsteemi strateegiline juhtimine. 1997, Tartu<br />
2. Soon A. Drinking water under field conditions. Tartu, 1997 pg 18<br />
131. Kuus K, Siilbek A. Demographic indicators and <strong>the</strong>ir calculation. Seminar workbook. Tartu, 1997<br />
pg 8<br />
132. Harro M. Healthy Nutrition. Seminar Workbook, 1997; 8 pg<br />
133. K.Kuus, Siilbek A. Tables and diagrams. Seminar Workbook, 1997; 8 pg<br />
134. Kuus K, Siilbek A. Demographic Indicators and <strong>the</strong>ir Calculation. Seminar Workbook, 1997; 8 pg.<br />
135. Kuus K, Siilbek A. Indicators <strong>of</strong> Child Mortality. Seminar workbook, 1997; 8 pg<br />
136. Soon A. Drinking water under field conditions, Seminar workbook, 1997; 18 pg<br />
137. Harro, M. Physical activity and physical fitness. OÜ Tartumaa Trükikoda, 1998<br />
138. Harro, M. Health promotion in School. OÜ Tartumaa Trükikoda, 1998 (english and russian)<br />
139. Harro, M. Health promotion in preschool. OÜ Tartumaa Trükikoda, 1998 (english and russian)<br />
140. Harro, M.. Nutrional assessment. OÜ Tartumaa Trükikoda, 1998 (english and russian)<br />
141. Harro, M. Ageless OÜ Tartumaa Trükikoda, 1998 (estonian and russian)<br />
142. Merisalu E, Saava A Toksilised ühendid töökeskkonnas. Tartu Ülikool, Tervishoiu instituut. Tartu,<br />
1998, 56 lk.<br />
143. Saava A Sissejuhatus rahvatervise õpgeainesse. Tartu Ülikool, Tervishoiu instituut. Tartu, 1998,<br />
51 lk.<br />
144. Sepp A. Meditsiini lühiajalugu I. Kiviajast kokaiinini. OÜ Tartumaa Trükikoda, 1998.<br />
145. Tamm V, Philips K, Meiesaar K.Riigi Sotsiaalmajandus Statistika. 1999: 1-158v<br />
146. Saava A, Trei T. Public Health in Estonia, 1998: 56 pg<br />
147. Saava A. Nutritional assessment, Tartu, 2000 pg 16<br />
148. Indermitte E ; Caution! - tick, Tartu, 2000 pg 16<br />
149. Soon A. Computer and health, Tartu, 2000 pg 16<br />
150. Merisalu E. Waste products and health, Tartu, 2000 pg 16<br />
145
APPENDIX I-VII<br />
Academic and administrative personnel: <strong>Department</strong> <strong>of</strong> Public Health<br />
PUBLIC HEALTH<br />
<strong>Name</strong> Title Load Area Gender Birth year Scientific degree Year <strong>of</strong> commencement Labour time (y)<br />
1. Raul-Allan Kiivet Pr<strong>of</strong>essor 1,00 Health Care Management Male 1960 Ph.D 1988 & 1999 16<br />
2. Astrid Saava Pr<strong>of</strong>essor 1,00 Environmental and Occupational Health Female 1938 Dr.Sci 1974 14<br />
3. Eda Merisalu Docent 1,00 Environmental and Occupational Health Female 1955 Ph.D 1995 16<br />
4. Maarike Harro Docent 1,00 Health Promotion Female 1960 Ph.D 1997 12<br />
5. Kersti Meiesaar Docent 1,00 Health Economics Female 1950 Cand.Sci 1980 28<br />
6. Kaja Põlluste Lecturer 1,00 Health Care Management Female 1967 11<br />
7. Argo Soon Lecturer 1,00 Environmental and Occupational Health Male 1965 MPH 1997 9<br />
8. Kersti Pärna Lecturer 1,00 Health Promotion Female 1960 MPH 1997 9<br />
9. Katrin Lang Lecturer 1,00 Epidemiology and Biostatistics Female 1963 Ph.D 2000 9<br />
10. Marina Kaarna Assistant 1,00 Health Care Management Female 1963 6<br />
11. Alar Sepp Assistant 1,00 Health Promotion Male 1963 9<br />
12. Astrid Siilbek Assistant 1,00 Epidemiology and Biostatistics Female 1969 MPH 1997 3<br />
13. Tatjana Leoško Assistant 1,00 Health Economics Female 1976 B.Sc 1999 2<br />
14. Diva Eensoo Researcher 1,00 Health Care Management Female 1963 M.Sc 2000 14<br />
15. Ene Indermitte Researcher 1,00 Environmental and Occupational Health Female 1967 MPH 1999 2<br />
16. Kaido Põlluste IT Specialist 0,50 Male 1961 3<br />
17. Merike Koppel Secretary 1,00 Female 1977 3<br />
18. Kaili Kulasalu Secretary 1,00 Female 1972 3<br />
19. Endla Anni Technical staff 1,00 Female 1941 38<br />
20. Ludmilla Jakobson Technical staff 1,00 Female 1954 6<br />
1 Cand.Sci & Dr.Sci are degrees <strong>of</strong> <strong>the</strong> Former Soviet Union which correspond to a Ph.D and Dr.Med, respectively<br />
147
APPENDIX I-VIII<br />
Curriculum Vitae <strong>of</strong> <strong>the</strong> staff<br />
PUBLIC HEALTH<br />
RAUL-ALLAN KIIVET Date <strong>of</strong> birth: November 30, 1960 in Tallinn, Estonia Gender:Male Citizenship:Estonian<br />
Address:Pohla 11-4, 50110 Tartu, ESTONIA Educational history:June 24, 1985 –<br />
graduated cum laude (MD) from <strong>the</strong> Faculty <strong>of</strong> Medicine, University <strong>of</strong> Tartu Academic degrees (with<br />
year and university): June 16, 1999 – Doctor <strong>of</strong> Medical Sciences (PhD) by presenting academic<br />
dissertation in clinical pharmacology, Karolinska Institute, Stockholm, Sweden December 19, 1988 –<br />
Candidate <strong>of</strong> Medical Sciences (PhD) by presenting academic dissertation in pharmacology,<br />
University <strong>of</strong> Tartu, Estonia 8. Employment and pr<strong>of</strong>essional experience: Since September 01,<br />
1996 – Pr<strong>of</strong>essor <strong>of</strong> Health Care Management, <strong>Department</strong> <strong>of</strong> Public Health, University <strong>of</strong> Tartu September<br />
21, 1985 to August 31, 1996 – Assistant and Associate Pr<strong>of</strong>essor in Clinical Pharmacology,<br />
<strong>Department</strong> <strong>of</strong> Pharmacology, University <strong>of</strong> Tartu October 01, 1988 to May 31, 1995 – Physician (parttime)<br />
in Tartu Lung Clinic 9. Administrative experience: Since 1998 – Head, <strong>Department</strong> <strong>of</strong> Public<br />
Health, University <strong>of</strong> Tartu 10. Honours and awards: none 11. Membership in academic and scientific<br />
societies: NATIONAL APPOINTMENTS Since 1997 – Member, Estonian Medical Research<br />
Council Since 1997 – Member, Advisory Board on Health Care to <strong>the</strong> Minister <strong>of</strong> Social Affairs Since<br />
1998 – Board Member, Estonian National Programme Against Tuberculosis INTERNATIONAL<br />
MEMBERSHIPS Since 1992 – Member <strong>of</strong> <strong>the</strong> WHO Drug Utilization Research Group Since 1995 –<br />
Council Member <strong>of</strong> <strong>the</strong> European Association <strong>of</strong> Clinical Pharmacology and Therapeutics Since 1997<br />
– Member <strong>of</strong> <strong>the</strong> International Society for Quality in Health Care 12. Current EU research program and<br />
grants: EU Copernicus Joint Research Project ERB IC15-CT98-0340 “Evaluation <strong>of</strong> efficacy and costs<br />
<strong>of</strong> schizophrenia treatment in four European countries”; 01.01.2001 – 31.12.2004 - Needs assessment<br />
for health care services in Estonia 13. Supervision <strong>of</strong> dissertations: 3 Master <strong>the</strong>sis defended, currently<br />
supervising 5 14. Publications: 72<br />
SAAVA, ASTRID Date <strong>of</strong> birth: 25.02.1938 Gender: Female Citizenship: Estonian Address: Ravila<br />
30a-27 Educational history: University <strong>of</strong> Tartu 1962Medical doctor University <strong>of</strong> Tartu<br />
1967Candidate <strong>of</strong> Med. Sci (PhD) University <strong>of</strong> Tartu 1974Doctor <strong>of</strong> Med. Sci Academic degrees<br />
(with year and university) University <strong>of</strong> Tartu 1962Medical doctor University <strong>of</strong> Tartu 1967Candidate <strong>of</strong><br />
Med. Sci (PhD) University <strong>of</strong> Tartu 1974Doctor <strong>of</strong> Med. Sci Employment and pr<strong>of</strong>essional experience<br />
University <strong>of</strong> Tartu, pr<strong>of</strong>essor <strong>of</strong> public health (PH)1998 - University <strong>of</strong> Tartu, pr<strong>of</strong>.<strong>of</strong> public health,<br />
head <strong>of</strong> Depart.<strong>of</strong> PH 1992 – 1998 University <strong>of</strong> Tartu, pr<strong>of</strong>., head <strong>of</strong> Depart.<strong>of</strong> Hygiene1990 – 1992<br />
University <strong>of</strong> Tartu, pr<strong>of</strong>.<strong>of</strong> hygiene1987 – 1990 Estonian Institute <strong>of</strong> Development Management,<br />
pr<strong>of</strong>.1979 – 1987 Institute <strong>of</strong> Applied Geophysics, Baltic Depart., sen. researcher1981 – 1985 Tallinn<br />
Technical University, head <strong>of</strong> department1974 – 1980 Tallinn Technical University, sen.<br />
researcher1970 – 1974 University <strong>of</strong> Tartu, lecturer at Depart.<strong>of</strong> Hygiene1962 - 1970 Administrative<br />
experience:Current job responsibilities Public health advisor at <strong>the</strong> Ministry <strong>of</strong> Social Affairs1995 - ….<br />
Advisory Group member <strong>of</strong> BRIMHEALTH1994 - President <strong>of</strong> <strong>the</strong> Tartu Association <strong>of</strong> Health<br />
Protection Specialists1988 - Member <strong>of</strong> Governmental Commission <strong>of</strong> Sustainable Development1996<br />
- 1999 Honour and awards: Membership in academic and scientific societis: Current research<br />
program and grants: Environmental health risks in Estonia Current grant funding Estonian Science<br />
Foundation project “Social-economic conditions, personal values and satisfaction with job and<br />
education <strong>of</strong> Estonian doctors” Estonian Public Health Foundation project “ Hazardous compounds in<br />
drinking water and <strong>the</strong>ir possible influence on health in Estonia” European Commission RP5<br />
LEONARDO da VINCI programme project “Pro Healthy Life – Interactive CD-ROM in Environmental<br />
Health for Pr<strong>of</strong>essionals and Decision Makers” Supervision <strong>of</strong> dissertations: Main publications (total<br />
number about 250)<br />
HARRO, MAARIKE (until 1997 Sallo) 2. Date <strong>of</strong> birth: 22 December 1960 3. Gender:Female 4.<br />
Citizenship:Estonian 5. Address:Work: Ravila 19, Tartu, Estonia 6. Educational history Postgraduate<br />
student in <strong>the</strong> Dep. <strong>of</strong> Public Health Internship in pediatrics in Tartu Childrens’ Hospital Medical<br />
Doctor, Tartu University, cum laude. 7. Academic degrees Ph.D. (in medicine, Public Health),<br />
University <strong>of</strong> Tartu 8. Employment and pr<strong>of</strong>essional experiences Docent <strong>of</strong> Health Promotion, Dep. <strong>of</strong><br />
Public Health Senior lecturer, Dep. <strong>of</strong> Public Health Lecturer, Dep. <strong>of</strong> Public Health Fellowship in <strong>the</strong><br />
School <strong>of</strong> Public Health, University <strong>of</strong> Albany and in <strong>the</strong> New York State <strong>Department</strong> <strong>of</strong> Health, Albany,<br />
New York, USA 1995, 1996, 1997, Fellowships (2 to 4 weeks) in <strong>the</strong> <strong>Department</strong> <strong>of</strong> Medical<br />
Pharmacology, 1998,1999, 2000 University <strong>of</strong> Uppsala, Sweden 9. Administrative experiences Head<br />
<strong>of</strong> <strong>the</strong> Division <strong>of</strong> Health Promotion in <strong>the</strong> <strong>Department</strong> <strong>of</strong> Public Health 10. Honours and awards Award<br />
for presentation at <strong>the</strong> Scientific Conference <strong>of</strong> <strong>the</strong> Medical faculty <strong>of</strong> <strong>the</strong> University <strong>of</strong> Tartu 11.<br />
Membership in academic and scientific societies Estonian Society <strong>of</strong> Physiologists Estonian Society <strong>of</strong><br />
149
SECTION I: APPENDIXES<br />
Nutritional Scientists 12. Current research program and grants: Grant from Estonian Science<br />
Foundation European Youth Heart Study in Estonia The prevalence <strong>of</strong> risk factors for CVD; <strong>the</strong><br />
prevalence and interactions between <strong>the</strong> determinants <strong>of</strong> <strong>the</strong> risk factors for CVD; 1999-2001Grant<br />
from Estonian Ministry <strong>of</strong> Social Affairs Validation <strong>of</strong> questionnaires assessing socioeconomic status,<br />
health beliefs, health related behaviour and self-rated health status in children and adolescents; 1997-<br />
Relationship beteen socioeconomic status and health and health related behavior in schoolchildren;<br />
1999-Trends in nutritional status, physical activity and antropometrical measures <strong>of</strong> Estonian<br />
schoolchildren 1998- Personality traits and biological markers as possible predictors <strong>of</strong> risk-taking<br />
behavior in schoolchildren – longitudinal study. 13. Supervision <strong>of</strong> dissertations Liis MerenäkkII year<br />
masterstudent Krystiine LiivII year masterstudent Jaana AlepIV year doctoral student Inga VillaI year<br />
doctoral student 14. Publications Monographs - 1 Peer-reviewed papers –16 Conference abstracts –<br />
90<br />
PÄRNA, KERSTI Date <strong>of</strong> birth: 15.02.1960 Gender: female Citizenship: Estonian Address: Salme 2a<br />
– 4, Tartu Educational history: 1996-1997 Master <strong>of</strong> Public Health student <strong>of</strong> University <strong>of</strong> Kuopio,<br />
Finland 1984-1985 Postgraduate student, Sports Medicine Centrum <strong>of</strong> Tartu 1978-1984 <strong>Department</strong><br />
<strong>of</strong> Sports Medicine, Faculty <strong>of</strong> Medicine, University <strong>of</strong> Tartu 1967-1978 Võru 1. Secondary School<br />
Academic degrees (with year and university): MD (1984, University <strong>of</strong> Tartu) MPH (Master <strong>of</strong> Public<br />
Health, 1997, University <strong>of</strong> Kuopio, Finland) Employment and pr<strong>of</strong>essional experience: 1998 -<br />
senior assistant, <strong>Department</strong> <strong>of</strong> Public Health, University <strong>of</strong> Tartu 1992 - 1998 assistant, <strong>Department</strong><br />
<strong>of</strong> Public Health, University <strong>of</strong> Tartu 1984 - 1985 postgraudate student, University <strong>of</strong> Tartu 1984 - 1992<br />
sports physician <strong>of</strong> bascetball team <strong>of</strong> Estonia Administrative experience: - Honours and awards: -<br />
Membership in academic and scientific societies: Estonian Society <strong>of</strong> Health Promotion Current<br />
research program and grants: Suitsetamise levimus Eesti arstide seas Supervision <strong>of</strong> dissertations:<br />
2 Bachelor dissertations Publications: 39<br />
SOON, ARGO Date <strong>of</strong> birth:15.04.1965 Gender:Male Citizenship: Estonian Address:Aardla 124-28,<br />
50415 Tartu, Estonia Educational history: University <strong>of</strong> Tartu, Medical Faculty, GP, 1992 Master <strong>of</strong><br />
Public Health, graduated at The Joseph H. And Belle R. Braun Hebrew University-Hadassah School<br />
Of Public Health And Community Medicine, Jerusalem, Israel, 1996-97, in February 1997; Master<br />
Thesis: “The Sick Building Syndrome in Hadassah Hospital Office Workers” Academic degrees (with<br />
year and university):MD, University <strong>of</strong> Tartu, 1992 MPH, Hebrew University, 1997 Employment and<br />
pr<strong>of</strong>essional experience: <strong>Department</strong> <strong>of</strong> Public Health, University <strong>of</strong> Tartu, lecturer 1992-1997, senior<br />
lecturer since 1997 Administrative experience: Honours and awards: 3 rd prize from Estonian Science<br />
Academy on contest <strong>of</strong> master-<strong>the</strong>sis 1997 Membership in academic and scientific societies:<br />
Estonian Society <strong>of</strong> Toxicology, Tartu Association <strong>of</strong> Health Protection Physicians, International Society<br />
<strong>of</strong> Indoor Air Quality Current research program and grants: Indoor air quality and it’s influence<br />
on health (environmental and occupational health aspects); grants: The Sick Building Syndrome in Office<br />
Workers in Estonia, Estonian Science Foundation grant nr. 3979, duration 1999-2001 Hygienic<br />
and Cultural Habits and Health <strong>of</strong> Residents <strong>of</strong> South-Estonia, National Program <strong>of</strong> Public Health,<br />
project nr. 99-54, duration 1999-2001 Supervision <strong>of</strong> dissertations: Publications: 14<br />
SEPP, ALAR Date <strong>of</strong> birth:July 18, 1963 in Tallinn Gender:male Citizenship:Estonian Address:Narva<br />
mnt. 108-1, Tartu 50303 Educational history: 1984-1992 – student in <strong>the</strong> Faculty <strong>of</strong> Medicine,<br />
University <strong>of</strong> Tartu, Tartu, Estonia 1981-1982 – student in <strong>the</strong> Medical School, Tallinn, Estonia –<br />
graduated from Tallinn Secondary No 22 Academic degrees (with year and university): Graduated<br />
from <strong>the</strong> Faculty <strong>of</strong> Medicine <strong>of</strong> <strong>the</strong> University <strong>of</strong> Tartu in 1992 Doctoral Student, <strong>Department</strong> <strong>of</strong> General<br />
Medicine, University <strong>of</strong> Tampere, Finland, since January 1998 Employment and pr<strong>of</strong>essional<br />
experience: August 1992 – . . . Assistant, <strong>Department</strong> <strong>of</strong> Public Health <strong>of</strong> <strong>the</strong> University <strong>of</strong> Tartu Administrative<br />
experience: - Member <strong>of</strong> <strong>the</strong> editorial board <strong>of</strong> <strong>the</strong> Biographyical-Lexicon <strong>of</strong>Estonian<br />
Scientist – Vice Chairman <strong>of</strong> <strong>the</strong> Estonian Society <strong>of</strong> Health Protectors – Shop stuard <strong>of</strong> <strong>the</strong> Trade<br />
Union, Faculty <strong>of</strong> Medicine, University <strong>of</strong> Tartu – Member <strong>of</strong> <strong>the</strong> Advisory Board at <strong>the</strong> History Museum<br />
<strong>of</strong> <strong>the</strong> University <strong>of</strong> Tartu – Member <strong>of</strong> <strong>the</strong> Amnesty International, Estonia 1992-1996 – Chairman <strong>of</strong><br />
<strong>the</strong> Estonian Students´ Fraternity Corp! Sakala Honours and awards: 1986 – Award Winner <strong>of</strong> <strong>the</strong><br />
Students´Research Contest <strong>of</strong> <strong>the</strong> USSR Academy <strong>of</strong> Medical Sciences 1992 - Head <strong>of</strong> <strong>the</strong> Border<br />
Guard <strong>of</strong>fice <strong>of</strong> Tallinn Airport 1993 – The Eagle Cross <strong>of</strong> Eesti Kaitseliit (voluntary military<br />
organisation) – The Centre for International Mobility CIMO Scholarship Award – The Reserve Officer<br />
<strong>of</strong> Estonia Membership in academic and scientific societies: Estonian Students´ Fraternity Corp!<br />
Sakala;Estonian Society <strong>of</strong> Health Protectors;Estonian Body <strong>of</strong> Reserve Officers Current research<br />
program and grants: Epidemiology and prevention on injuries, and safety promotion Estonian<br />
Science Foundation, grant ESF1053 1994-1996) “Job satisfaction, values and social-economical<br />
150
PUBLIC HEALTH<br />
condition <strong>of</strong> physicians” 145 000 EEK (USD 9 700). Estonian Science Foundation, grant ESF4430<br />
“Job satisfaction, values and social-economical condition <strong>of</strong> physicians” (2000-2002). Budget 2000:<br />
100 000 EEK (USD 6 667). Supervision <strong>of</strong> dissertations: - Publications:A – 1, B – 3, C – 10, D – 2,<br />
E – 22.<br />
PÕLLUSTE, KAJA Date <strong>of</strong> birth: February 5 th , 1967 Gender: female Citizenship: Estonian Address:<br />
Kaunase 44-30, Tartu 50607 Educational history: 1997 – 2000The Nordic School <strong>of</strong> Public Health,<br />
Master student 1993 – 1996postgraduate training in public health in <strong>the</strong> Nordic School <strong>of</strong> Public<br />
Health, <strong>the</strong> Ne<strong>the</strong>rlands School <strong>of</strong> Public Health, and London School <strong>of</strong> Hygiene and Tropical Medicine<br />
1984 – 1990University <strong>of</strong> Tartu, Faculty <strong>of</strong> medicine 1973 – 1984Räpina Secondary School Academic<br />
degrees (with year and university): Medical Doctor – University <strong>of</strong> Tartu, 1990 Master <strong>of</strong> Public<br />
Health – <strong>the</strong> Nordic School <strong>of</strong> Public Health, 2000 Employment and pr<strong>of</strong>essional experience: –<br />
…… Assistant Pr<strong>of</strong>essor, <strong>Department</strong> <strong>of</strong> Public Health, University <strong>of</strong> Tartu Administrative experience:<br />
Since 1999 – Estonian coordinator <strong>of</strong> <strong>the</strong> Baltic Rim Partnership for Public Health<br />
(BRIMHEALTH – a collaboration between <strong>the</strong> Baltic countries, <strong>the</strong> Nordic School <strong>of</strong> Public Health, and<br />
WHO Euro) Honours and awards: no Membership in academic and scientific societies: Estonian<br />
College <strong>of</strong> Health Care Executives – member <strong>of</strong> <strong>the</strong> board Current research program and grants:<br />
Quality <strong>of</strong> health care in Estonia from <strong>the</strong> patients’ perspective Supervision <strong>of</strong> dissertations: no<br />
Publications: No <strong>of</strong> publication 46<br />
KAARNA, MARINA Date <strong>of</strong> birth: 15.01.1963 Gender: female Citizenship: Estonian Address: Turu 31-<br />
213, Tartu 50106 Educational history: 1993 University <strong>of</strong> Tartu, Medical faculty Tartu Secondary<br />
School Academic degrees (with year and university): Medical Doctor – University <strong>of</strong> Tartu, 1995<br />
Postgraduate training in public health in <strong>the</strong> Nordic School <strong>of</strong> Public Health and Ne<strong>the</strong>rlands School <strong>of</strong><br />
Public Health, 1996 – Employment and pr<strong>of</strong>essional experience: 1993 – 1995 Maarjamõisa Hospital,<br />
internship - ….. Assistant Pr<strong>of</strong>essor, <strong>Department</strong> <strong>of</strong> Public Health, University <strong>of</strong> Tartu Administrative<br />
experience: no Honours and awards: no Membership in academic and scientific societies:<br />
Committee <strong>of</strong> Bioethics <strong>of</strong> Estonian Medical Association – member Estonian College <strong>of</strong> Health Care<br />
Executives – member Current research program and grants: Quality <strong>of</strong> health care in Estonia from<br />
<strong>the</strong> patients` perspective Supervision <strong>of</strong> dissertations: no Publications: No publications 21<br />
LANG, KATRIN Date <strong>of</strong> birth: 04.05.63 Gender: female Citizenship: estonian Address: Ravila St 76-<br />
6, 50408 Tartu, Estonia Educational history: Doctoral (PhD) Programme in Epidemiology, University<br />
<strong>of</strong> London, London School <strong>of</strong> Hygiene and Tropical Medicine, England, started in 1999 Master’s Programme,<br />
University <strong>of</strong> Nottingham, England, 1995-1996 University <strong>of</strong> Tartu, Medical Faculty,<br />
<strong>Department</strong> <strong>of</strong> Pediatrics, diploma with distinction, Tartu, Estonia, 1987 Tartu Miina Härma Secondary<br />
School, special English language school, 1981 Academic degrees (with year and university): Master<br />
<strong>of</strong> Public Health, 1996, Univesrity <strong>of</strong> Nottingham, England Master <strong>of</strong> Philosophy, 2000, University <strong>of</strong><br />
London, London School <strong>of</strong> Hygiene and Tropical Medicine, England Employment and pr<strong>of</strong>essional<br />
experience: <strong>Department</strong> <strong>of</strong> Public Health, University <strong>of</strong> Tartu, senior teaching assistant, 1997 up to<br />
present <strong>Department</strong> <strong>of</strong> Public Health, University <strong>of</strong> Tartu, teaching assistant, 1992-1997 University <strong>of</strong><br />
Tartu Children’s Hospital, physician, 1989-1991 Tallinn First Children’s Hospital, residency training,<br />
1988 Administrative experience: <strong>Department</strong> <strong>of</strong> Public Health, University <strong>of</strong> Tartu, acting head <strong>of</strong> <strong>the</strong><br />
Chair <strong>of</strong> Epidemiology and biostatistics, 1997 up to present Honours and awards: none Membership<br />
in academic and scientific societies: none Current research program and grants: Main research<br />
topic: Doctoral <strong>the</strong>sis: Cancer registration in Estonia: Validity, Rates and Public Health O<strong>the</strong>r projects:<br />
Children’s injuries in Estonia (in collaboration with WHO and European Centre on Health <strong>of</strong> Societies<br />
in Transition), study <strong>of</strong> deaths <strong>of</strong> men aged 20-49 years that have lead to forensic autopsies, and<br />
relation to alcohol (in collaboration with European Centre on Health <strong>of</strong> Societies in Transition and London<br />
School <strong>of</strong> Hygiene and Tropical Medicine) Supervision <strong>of</strong> dissertations: none Publications:<br />
one article in Estonian medical journal, one internet publication: a report (45 pages).<br />
MEIESAAR, KERSTI Date <strong>of</strong> birth: 25 th <strong>of</strong> April 1950 Gender: Female Citizenship: Estonian Address:<br />
50104 Kalevi 113, Tartu, Estonia Educational history: econometrics and statistics, Faculty <strong>of</strong> Economics,<br />
University <strong>of</strong> Tartu, 1973 Academic degrees (with year and university): PhD 1980, Institute <strong>of</strong><br />
Economics, Estonian Academy <strong>of</strong> Science, Tallinn Employment and pr<strong>of</strong>essional experience: 1973<br />
– 1995 Faculty <strong>of</strong> Economics, University <strong>of</strong> Tartu, since 01.01.1996 – Associate Pr<strong>of</strong>essor, Head <strong>of</strong><br />
Chair <strong>of</strong> Health Economics, Institute <strong>of</strong> Public Health, Faculty <strong>of</strong> Medicine, University <strong>of</strong> Tartu. Administrative<br />
experience: since 01.01.1996 – Head <strong>of</strong> Chair <strong>of</strong> Health Economics, Institute <strong>of</strong> Public<br />
Health, Faculty <strong>of</strong> Medicine, University <strong>of</strong> Tartu. Honours and awards: Order <strong>of</strong> Merit, Rector <strong>of</strong> University<br />
<strong>of</strong> Tartu, April 2000 Membership in academic and scientific societies: Founder-member <strong>of</strong><br />
Estonian Society <strong>of</strong> Statisticians, Founder-member and Chairman <strong>of</strong> Estonian Society <strong>of</strong> Health<br />
151
SECTION I: APPENDIXES<br />
Economists Current research program and grants: Scientific Grant “Evaluation <strong>of</strong> primary health care<br />
reform in Estonia” 1998 - 2002, Estonian Scientific Foundation. Supervision <strong>of</strong> dissertations: Supervisor<br />
<strong>of</strong> PhD students Agris Koppel and Katrin Sihver Publications: Total number <strong>of</strong> scientific publications - 73,<br />
and 22 manuscripts as a final reports <strong>of</strong> scientific projects.<br />
MERISALU, EDA Date <strong>of</strong> birth: 1955 January 6 th, Gender: Female Citizenship: Estonian Address: Str. Uus<br />
3-6, Tartu Educational history: 1977 Faculty <strong>of</strong> Physical Education, University <strong>of</strong> Tartu 1985 Medical Faculty,<br />
University <strong>of</strong> Tartu Ülikool Academic degrees (with year and university): 1995 Kaunas Medical Academy,<br />
Doctor <strong>of</strong> Medical Sciences Employment and pr<strong>of</strong>essional experience: 1985-1995 Institute <strong>of</strong> General<br />
and Molecular Pathology, University <strong>of</strong> Tartu (laboratory assistant, researcher) 1995-2001 <strong>Department</strong><br />
<strong>of</strong> Public Health, University <strong>of</strong> Tartu (assistant, associate pr<strong>of</strong>essor) Administrative experience: Honours<br />
and awards: Two (3 rd prizes) awards in <strong>the</strong> Annual Student Scientific Conference <strong>of</strong> <strong>the</strong> Medical Faculty,<br />
University <strong>of</strong> Tartu; Pille Saar (1997), and Kristina Kohv (1998) – both in Nursing Sciences); One 3 rd prize <strong>of</strong><br />
Estonian Republic for <strong>the</strong> scientific paper <strong>of</strong> Bachelor Degree, 1999; (Merle Varik – Nursing Sciences) Annual<br />
Prize for <strong>the</strong> Health Promotion Project “Work stress among teachers and its’ management in <strong>the</strong> Estonian<br />
comprehensive schools”, 2000 Membership in academic and scientific societies: Current research<br />
program and grants: Supervision <strong>of</strong> dissertations: Liivi Linnumets “Training problems and<br />
needs <strong>of</strong> nurses in Jõgeva district”, <strong>the</strong>sis <strong>of</strong> Bachelor Degree Merle Varik “Work stress and health among<br />
head nurses”, <strong>the</strong>sis <strong>of</strong> Bachelor Degree Kristi Toode “Work stress and health among nurses”, dissertation<br />
<strong>of</strong> Tartu Medical School Laima Balasova “Burnout syndrome among nurses <strong>of</strong> Neuro Intensive Care Unit”,<br />
dissertation <strong>of</strong> Tartu Medical School Pille Saar “Work stress and job satisfaction among nurses <strong>of</strong><br />
Psychiatric <strong>Department</strong>s”, <strong>the</strong>sis <strong>of</strong> Bachelor Degree Irma Nool “Relationships between burnout indices,<br />
style <strong>of</strong> management, personality and health <strong>of</strong> head nurses”, <strong>the</strong>sis <strong>of</strong> Bachelor Degree Publications:<br />
1985-2000: Total number 56:.<br />
EENSOO, DIVA Date <strong>of</strong> birth: 14 <strong>of</strong> December 1963 Gender: female Citizenship: Estonian Address: Pikk<br />
139-39, 50606 Tartu, ESTONIA Educational history: University <strong>of</strong> Tartu, Faculty <strong>of</strong> Medicine, pharmacy<br />
1982-1987 Master studies in biomedicine (Public Health) 1996-1998 Academic degrees (with year and<br />
university): Master <strong>of</strong> Science in Public Health, 2000, University <strong>of</strong> Tartu Employment and pr<strong>of</strong>essional<br />
experience: 1987-2000 senior laboratory assistant in <strong>Department</strong> <strong>of</strong> Public Health, University <strong>of</strong> Tartu since<br />
2000 researcher in <strong>Department</strong> <strong>of</strong> Public Health, University <strong>of</strong> Tartu Administrative experience:- Honours<br />
and awards:- Membership in academic and scientific societies: Estonian Society <strong>of</strong> Biological<br />
Psychiatry, member Scientific Health Protection Society <strong>of</strong> Tartu, member Current research program and<br />
grants: Main topics are physical activity in assotiation with mental health and personality traits; biological<br />
indicators, <strong>the</strong>ir assotiation with mental health, personality traits and health-behaviour; family socioeconomic<br />
status and health-related behaviour in children; environmental risks and <strong>the</strong>ir influence on health.<br />
Supervision <strong>of</strong> dissertations:- Publications: Total: 57 publications<br />
LEOŠKO, TATJANA Date <strong>of</strong> birth: 17 July 1976 Gender: Female Citizenship: Estonian Address: Nooruse 7-<br />
720, Tartu 50411 Educational history: Since 09.98 - University <strong>of</strong> Tartu, Faculty <strong>of</strong> Economics and Business<br />
Administration, MA student Sept.1999 – Dec. 1999 University <strong>of</strong> Sou<strong>the</strong>rn Denmark – Odense University,<br />
Denmark Diploma <strong>of</strong> European Studies; four months study <strong>of</strong> EU economics and politics. 1994 – 1998<br />
University <strong>of</strong> Tartu, Faculty <strong>of</strong> Economics and Business Administration, BA in economics Specialisations:<br />
Finance and Investmentslver<br />
medal Academic degrees (with year and university): BA in economics, 1998, University <strong>of</strong> Tartu Employment<br />
and pr<strong>of</strong>essional experience: Since Sept 1999 - Assistant Lecturer, Chair <strong>of</strong> Health Economics,<br />
<strong>Department</strong> <strong>of</strong> Public Health, Faculty <strong>of</strong> Medicine, University <strong>of</strong> Tartu. Responsibilities include: teaching<br />
courses in Health Economics, organising seminars and practical work, supervising students, scientific work.<br />
Summer 1999 - Teller, United Bank <strong>of</strong> Estonia, Narva. Responsibilities include: client service Administrative<br />
experience: Honours and awards: Awarded a University Scholarship (1995 - 1996) and The Scholarship<br />
<strong>of</strong> Ministries <strong>of</strong> Denmark (1999) Membership in academic and scientific societies: Current research<br />
program and grants: Supervision <strong>of</strong> dissertations: Publications: 1<br />
INDERMITTE, ENE Date <strong>of</strong> birth: 21.04.1967 Gender: Female Citizenship: Estonian Address: Turu 7-16<br />
Tartu 51004 Educational history:Dipl. Biology with specialisation to cytology, 1992, University <strong>of</strong> Tartu<br />
Academic degrees (with year and university): Master <strong>of</strong> Public Health, 1999, University <strong>of</strong> Kuopio, Finland<br />
Employment and pr<strong>of</strong>essional experience: 2000 - Researcher, <strong>Department</strong> <strong>of</strong> Public Health, University<br />
<strong>of</strong> Tartu – 2000 Laboratory assistant, <strong>Department</strong> <strong>of</strong> Public Health, University <strong>of</strong> Tartu – 1998 Laboratory<br />
assistant, Institute <strong>of</strong> Zoology and Hydrobiology, University <strong>of</strong> Tartu Administrative experience: - Honours<br />
and awards: - Membership in academic and scientific societies: - Current research program and<br />
grants: Supervision <strong>of</strong> dissertations: - Publications: 5<br />
152
BIOLOGY AND GENETICS<br />
<strong>Name</strong> <strong>of</strong> <strong>the</strong> <strong>Department</strong>: <strong>Department</strong> <strong>of</strong> General and Molecular Pathology<br />
Head <strong>of</strong> <strong>Department</strong>: Pr<strong>of</strong>essor Aavo-Valdur Mikelsaar<br />
<strong>Name</strong> <strong>of</strong> <strong>the</strong> Chair: Human Biology and Genetics<br />
Head <strong>of</strong> <strong>the</strong> Chair: Pr<strong>of</strong>essor Aavo-Valdur Mikelsaar<br />
Subject codes: ARMP.01.016; ARMP.01.014; ARMP.01.013;<br />
ARMP.01.025<br />
I. CONTENT OF THE TEACHING<br />
• The academic year at <strong>the</strong> University <strong>of</strong> Tartu is divided into two semesters -<br />
<strong>the</strong> fall semester and <strong>the</strong> spring semester. The fall semester starts on Monday<br />
closest to <strong>the</strong> 1st <strong>of</strong> September and lasts till <strong>the</strong> 2 nd week <strong>of</strong> February<br />
(18 weeks). Classes usually end before Christmas, and continue 2 weeks<br />
during January. The examination period lasts for 2 weeks (one week in <strong>the</strong><br />
end <strong>of</strong> January and one week in February). After a week <strong>of</strong> vacation, <strong>the</strong><br />
spring semester starts on <strong>the</strong> second week <strong>of</strong> February and lasts till <strong>the</strong> end<br />
<strong>of</strong> June. The auditorial work <strong>of</strong> <strong>the</strong> spring semester ends on <strong>the</strong> last week <strong>of</strong><br />
May and so June is mainly for exams.<br />
• Our chair teaches 2 different subjects at <strong>the</strong> diploma level for students <strong>of</strong><br />
Medical Faculty – “BIOLOGY” (6 CP) and “MEDICAL GENETICS” (2 CP)<br />
• At <strong>the</strong> doctoral level our chair teaches “HUMAN GENETICS” (1 CP).<br />
• Staff <strong>of</strong> <strong>the</strong> Chair <strong>of</strong> Human Biology and Genetics consists <strong>of</strong> 25 persons<br />
including, according to workload, 8 teaching (1.0 pr<strong>of</strong>essors, 2.0 docents<br />
and 4.0 assistants), 6.0 research, 1 administrative, and 10 technical positions.<br />
• Distribution by gender: 13 male, 12 female persons. Distribution <strong>of</strong> academic<br />
staff by age: 1 between 20 – 30 years, 8 between 30 - 39 years, 7<br />
between 40 - 49 years, 6 between 50 - 59 years and 3 between 60 – 65<br />
years.<br />
• 1 persons have half-time occupation in teaching (assistant) and half-time in<br />
research, 2 person is employed as half-time researcher and 1 person as<br />
half-time assistant. All o<strong>the</strong>rs have full-time positions.<br />
• 5 Doctoral Students and 3 Residents in Medical genetics have temporary<br />
assignments.<br />
• Teaching <strong>of</strong> <strong>the</strong>se subjects at <strong>the</strong> Chair <strong>of</strong> Human Biology and Genetics is<br />
organized on two levels: <strong>the</strong> diploma level and <strong>the</strong> doctoral level.<br />
• The medicine diploma level programme (6 years) consists <strong>of</strong> 10 compulsory<br />
curricula during <strong>the</strong> 1st year <strong>of</strong> studies, 9 compulsory curricula during <strong>the</strong><br />
2nd year, 12 compulsory curricula during <strong>the</strong> 3rd year, 16 compulsory curricula<br />
during <strong>the</strong> 4th year, 9 compulsory curricula during <strong>the</strong> 5th year and 7<br />
compulsory curricula during <strong>the</strong> 6 th year <strong>of</strong> studies.<br />
Our chair teaches following subjects:<br />
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SECTION I: SELF-EVALUATION<br />
• Biology (6 CR) during <strong>the</strong> 1 st year; teaching staff: 4 persons (1 docent, 3<br />
assistants);<br />
• Medical genetics (2 CR) during <strong>the</strong> 3rd year; teaching staff: 4 persons (1<br />
pr<strong>of</strong>essor, 1 docent, 2 assistants (both with 0,5 position).<br />
• The stomatology diploma level programme (5 years) consists also a number<br />
<strong>of</strong> compulsory curricula and our chair teaches following subjects:<br />
• Biology (6 CR) during <strong>the</strong> 1 st year; teaching staff: 4 persons (1 docent, 3<br />
assistants);<br />
• The nursery diploma level programme (4 years) consists a subject “Genetics”<br />
(1 CP), teaching staff: 1 person (1 pr<strong>of</strong>essor).<br />
1. Describe shortly <strong>the</strong> main study and student evaluation methods applied at<br />
<strong>the</strong> department.<br />
Biology<br />
Teaching <strong>of</strong> “Biology” takes place during <strong>the</strong> fall semester <strong>of</strong> <strong>the</strong> 1<br />
154<br />
st year. The<br />
amount <strong>of</strong> this subject is 72 hours <strong>of</strong> lectures, 90 hours <strong>of</strong> practicums and 78<br />
hours <strong>of</strong> independent study. This subject gives 6 credit poits (CP). “Biology” is<br />
tightly correlated with course <strong>of</strong> “General histology and embryology” (2 CP) in<br />
<strong>the</strong> frames <strong>of</strong> “Medical Biology I” (in all 8 CP).<br />
It means that <strong>the</strong> separate course <strong>of</strong> histology and embryology (lectures and<br />
practicums) as a part <strong>of</strong> “Medical biology I” takes place at <strong>the</strong> Chair <strong>of</strong> Histology<br />
and Embryology but general problems <strong>of</strong> development are <strong>the</strong> matter <strong>of</strong><br />
subject “Biology”.<br />
Lectures. A lecture lasts for 2 academic hours (45+45) or 90 minutes, usually<br />
with a break between <strong>the</strong> academic hours. The structure <strong>of</strong> a lecture varies<br />
according to lecturers and courses, yet <strong>the</strong> prevailing model seems to be <strong>the</strong><br />
presentation <strong>of</strong> material by <strong>the</strong> lecturer (4/5 <strong>of</strong> <strong>the</strong> lecture time), followed by<br />
discussion <strong>of</strong> <strong>the</strong> presented material and answering questions which have<br />
arisen during <strong>the</strong> lecture (1/5 <strong>of</strong> <strong>the</strong> lecture time) in <strong>the</strong> end.<br />
Using visual aids (data projectors for presentation <strong>of</strong> texts and illustrations,<br />
overheads, videos) during <strong>the</strong> lecture is widely practiced.<br />
Students have 4 hours <strong>of</strong> lectures in “Biology” every week during <strong>the</strong> fall semester.<br />
The course <strong>of</strong> lectures gives students an understanding, basic knowledge<br />
and skills in modern biology. The course <strong>of</strong> “Biology” is a basis for all o<strong>the</strong>r<br />
biological subjects (physiology, biochemistry, biophysics, pharmacology,<br />
medical genetics etc.) what students will run later.<br />
Lectures in “Biology” (72 hours) have following topics:<br />
• Introduction (2 h)<br />
• Modern cell and molecular biology (8 hours)<br />
• Biology <strong>of</strong> development (14 h)<br />
• Genetics (36 h)
BIOLOGY AND GENETICS<br />
• Theory <strong>of</strong> evolution (6 h)<br />
• Ecology (6 h)<br />
Lectures in “Biology” for medical students and for students <strong>of</strong> stomatology is<br />
tought by docent R.Masso, Ph.D.<br />
Practicums. Practicums have an important role in teaching biology and medical<br />
parasitology - it is where skills are acquired for work with microscopes, to<br />
conduct an experimental study and to understand morphology and life cycles<br />
<strong>of</strong> human parasites. A practical class lasts for 2 or 3 academic hours, usually<br />
without a break between <strong>the</strong> academic hours. Practicums are held in special<br />
study rooms, using <strong>the</strong> necessary equipment.<br />
Using visual aids (data projectors for presentation <strong>of</strong> texts and illustrations,<br />
overheads, videos) during <strong>the</strong> practicums is widely practiced.<br />
Students have 5 hours <strong>of</strong> practicums every week.<br />
The course <strong>of</strong> practicums are related to course <strong>of</strong> lectures and gives students<br />
<strong>the</strong> basic knowledge and skills in cell biology, genetics, biology <strong>of</strong> development<br />
and medical parasitology (as a part <strong>of</strong> human ecology).<br />
Topics <strong>of</strong> practicums in “Biology” are following:<br />
• Cell biology (15 h)<br />
• Biology <strong>of</strong> development (15 h)<br />
• Medical parasitology (31 h)<br />
• Genetics (20 h)<br />
• Comparative morphology (as a part <strong>of</strong> evolutionary biology, 9 h)<br />
To evaluate <strong>the</strong> knowledge acquired by <strong>the</strong> students during practicums, <strong>the</strong>y<br />
take written tests after passing subsequent part (5 tests). Successful passing<br />
<strong>the</strong>se tests deliver student from answer <strong>of</strong> <strong>the</strong>se questions during oral examination<br />
later.<br />
Practicums for students <strong>of</strong> medicine and stomatology are supervisored by<br />
assistants A. Adojaan, MD, Ph.D., A. Saag, M.Sc., and M. Masso, M.Sc.<br />
Exams. To evaluate <strong>the</strong> knowledge acquired by <strong>the</strong> students, <strong>the</strong>y take an<br />
oral examination.<br />
The examination in subject “Medical biology I” is realized by lectures <strong>of</strong> our<br />
chair. Final mark is formed as a sum <strong>of</strong> marks for <strong>the</strong>oretical part passed during<br />
lectures in “Biology”, results in practicums in “Biology” and results in subject<br />
“General histology and embryology”.<br />
Medical Genetics<br />
Teaching <strong>of</strong> medical genetics took place during 1996-1998 years at <strong>the</strong> same<br />
time both for 3 rd and 6 th year students, and in <strong>the</strong> year 1998/1999 only for 3 rd<br />
year students. Since automn <strong>of</strong> 1999 up to <strong>the</strong> spring <strong>of</strong> 2001 <strong>the</strong>re was no<br />
teaching <strong>of</strong> medical genetics due to general changes in medical curriculum,<br />
and it was decided to bring <strong>the</strong> teaching <strong>of</strong> medical genetics in to <strong>the</strong> 5 th year<br />
<strong>of</strong> studium (see part VI.p.11).<br />
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SECTION I: SELF-EVALUATION<br />
156<br />
The teaching <strong>of</strong> 6 th year students took place in 2 weeks-cycle seminarpractical<br />
works form (6 hours per day). Practicums were hold in a special<br />
study room, using visual aids<br />
(overheads and diaprojectors for presentation <strong>of</strong> texts and illustrations and TV<br />
apparatus for videos). At beginning <strong>of</strong> <strong>the</strong> practicum <strong>the</strong>re was a <strong>the</strong>oretical<br />
part introducing into <strong>the</strong> subject, which was followed by practical part including<br />
discussion about disease cases. The students obtained direct experience in<br />
karyotyping, syndrome diagnostics (using P.O.S.S.U.M), and solving <strong>of</strong> genetic<br />
tasks for consulting patients with genetic diseases.<br />
The teaching <strong>of</strong> 3 rd year students lasted from 1995 up to spring 1999. It<br />
took place in “classical” form with lectures and practical works.<br />
A lecture lasted for 2 academic hours (45+45) or 90 minutes, usually with a<br />
break between <strong>the</strong>m . Using visual aids ( overheads, diaprojectors) during <strong>the</strong><br />
lecture was widely practiced at that time.<br />
Students had 2 hours <strong>of</strong> lectures in “Medical Genetics” every week during <strong>the</strong><br />
spring semester. The course <strong>of</strong> lectures gave students an understanding, basic<br />
knowledge and skills in modern medical genetics.<br />
Lectures in “Medical Genetics” (30 hours) had <strong>the</strong> following topics:<br />
• Introduction<br />
• Chromosome structure and abnormalities<br />
• Gene structure, function and mutations<br />
• Mendelian inheritance and diseases<br />
• Multifactorial inheritance and diseases<br />
• Mitochondrial inheritance and diseases<br />
• Cancer genetics<br />
• Genetic consultation and gene <strong>the</strong>rapy<br />
• Ethical issues in medical genetics<br />
Lectures in “Medical Genetics” for medical students were thought by<br />
pr<strong>of</strong>.Aavo-Valdur Mikelsaar and docent Ruth Mikelsaar.<br />
Practicums. Practicums have an important role in teaching medical genetics.<br />
The students had 32 hours <strong>of</strong> practical works.<br />
Topics <strong>of</strong> practicums in “Medical Genetics” were <strong>the</strong> following ones:<br />
• Chromosome analysis methods<br />
• Karyotype analysis, identification <strong>of</strong> aberrant chromosomes<br />
• Computer-aided genetic syndrome analysis using P.O.S.S.U.M, and<br />
O.S.S.U.M.<br />
• DNA purification, electrophoresis<br />
• PCR and restriction (RFLP) analysis<br />
• DNA blotting and hybridization<br />
• DNA sequencing and cloning
BIOLOGY AND GENETICS<br />
• Molecular methods in laboratory medicine and identification <strong>of</strong> disease<br />
genes<br />
• Paternity and person identification using molecular genetic methods.<br />
To evaluate <strong>the</strong> knowledge acquired by <strong>the</strong> students during practicums, <strong>the</strong>y<br />
passed written tests after <strong>the</strong> end <strong>of</strong> subsequent part . Successful passing <strong>of</strong><br />
<strong>the</strong>se tests set students free from answer <strong>of</strong> <strong>the</strong>se questions during oral examination<br />
later.<br />
Practicums for students <strong>of</strong> medicine and stomatology are supervisored by<br />
docent Ruth Mikelsaar and assistants Gunnar Tasa and Mart Uusküla.<br />
Exams. To evaluate <strong>the</strong> knowledge acquired by <strong>the</strong> students <strong>the</strong>y had an oral<br />
examination,and an additional written tests for those students who did not<br />
pass successfully all tests after practical works.<br />
Genetics<br />
The teaching <strong>of</strong> genetics for nursery students has been fully as a lecture<br />
course <strong>of</strong> medical genetics: 2 hours <strong>of</strong> lectures per week.<br />
The topics have been:<br />
• The molecular basis <strong>of</strong> human genetics<br />
• Human chromosomes<br />
• Chromosome aberrations<br />
• Formal genetics: mendelian diseases<br />
• Mitochondrial diseases<br />
• Multifactorial inheritance and disease<br />
• Cancer genetics<br />
• Pharmacogenetics<br />
• Genetic consultation<br />
• Gene <strong>the</strong>rapy<br />
Lectures in “ Genetics” for nursery students were tought by pr<strong>of</strong>.Aavo-Valdur<br />
Mikelsaar .<br />
Evaluation. To evaluate <strong>the</strong> knowledge acquired by <strong>the</strong> students <strong>the</strong>y had a<br />
written test for 3 main topics <strong>of</strong> lectures.<br />
2. How have <strong>the</strong> aims and objectives described in <strong>the</strong> curriculum changed<br />
during <strong>the</strong> past five years?<br />
Biology<br />
1. From <strong>the</strong> academic year 1999/2000 <strong>the</strong> course <strong>of</strong> “Biology” is compressed<br />
to one semester (before it lasts two semesters) and <strong>the</strong> total amount <strong>of</strong><br />
subject is decreased from 7 CP to 6 CP.<br />
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158<br />
2. Compared with earlier curriculum, more emphasis is now paid to molecular<br />
biology and genetics.<br />
3. The traditional elementary course <strong>of</strong> tissue biology has been given up. All<br />
matter about this is now a part <strong>of</strong> course <strong>of</strong> “General histology and embryology”.<br />
4. The course is build up now on different manuals. The manuals for different<br />
parts <strong>of</strong> course are following:<br />
♦ For cell and molecular biology – B.Alberts et al.: “Molecular biology <strong>of</strong><br />
<strong>the</strong> cell”, Garland Publishing Inc., N.Y., 3rd ed., 1994, 4 th ed. 1998.<br />
♦ J.Kimball:”Biology pages”<br />
(http://www.edc.com/~jkimball/BiologyPages/W/Welcome.html);<br />
♦ For developmental biology – B.Alberts et al.: “Molecular biology <strong>of</strong> <strong>the</strong><br />
cell”, Garland Publishing Inc., N.Y., 3rd ed., 1994, 4 th ed. 1998.<br />
♦ J.Kimball:”Biology pages”<br />
(http://www.edc.com/~jkimball/BiologyPages/W/Welcome.html);<br />
♦ For genetics – different manuals made by our lecturers and available<br />
from <strong>the</strong> Internet – R.Masso: “Genetics”<br />
(http://biomedicum.ut.ee/~masso/2Geneetika.htm);<br />
♦ R.Teinberg: “Genetics <strong>of</strong> population”<br />
(http://biomedicum.ut.ee/~masso/Teinberg.htm ;<br />
http://biomedicum.ut.ee/~masso/Teinberg2.html );<br />
♦ M.Viikmaa: “Glossary <strong>of</strong> classical genetics”<br />
(http://biomedicum.ut.ee/~martv/genolex.html);<br />
♦ M.Viikmaa: “History <strong>of</strong> genetics”<br />
(http://biomedicum.ut.ee/~martv/geneetika-ajalugu.htm);<br />
♦ For <strong>the</strong>ory <strong>of</strong> evolution – H.Kallak “Biological evolution”, Valgus, Tallinn,<br />
1990.<br />
♦ For ecology – V.Masing: “Lexicon in ecology”, Eesti Entsüklopeediakirjastus,<br />
Tallinn, 1992.<br />
♦ For practicums – manuals made by lecturers <strong>of</strong> our chair:<br />
♦ R.Masso et al.: “Practicums in biology I”, TÜ Kirjastus, Tartu, 1997, 2 nd<br />
ed. 1999, 83 pages.<br />
♦ R.Masso et al.: “Practicums in biology II”, TÜ Kirjastus, Tartu, 1998, 2 nd<br />
ed. 1999, 169 pages.<br />
♦ A.Heinaru, M.Viikmaa: “Tasks in genetics”, Tartu, Tartu Ülikooli Kirjastus,<br />
1991, 158 pages.<br />
5. We had changes in courses taught in o<strong>the</strong>r languages than Estonian. In<br />
general, lectures and practicums given by <strong>the</strong> teaching staff <strong>of</strong> <strong>the</strong> Chair <strong>of</strong><br />
Human Biology and Genetics are in Estonian. From <strong>the</strong> academic year<br />
1999/2000 <strong>the</strong> course <strong>of</strong> “Biology” in Russian is cancelled. Before this we<br />
had a special groups <strong>of</strong> students who ran <strong>the</strong> curriculum in Russian.<br />
After changes in <strong>the</strong> programme <strong>of</strong> secondary school and with introducing<br />
an obligatory state examination in Estonian language for pupils <strong>of</strong> secondary<br />
schools with Russian language <strong>the</strong> necessity for teaching in Russian<br />
disappeared.
BIOLOGY AND GENETICS<br />
During <strong>the</strong> last 5 years we started to teach foreign students (mostly from<br />
Finland) in English. They study all subjects in English during first 2 years.<br />
6. From <strong>the</strong> academic year 1999/2000 we use for teaching rooms in <strong>the</strong> new<br />
building <strong>of</strong> Biomedicum with good equipment. The halls for lectures and<br />
rooms for practicums have all technical equipment for teaching (data projectors,<br />
PCs, overheads, videos). We have obtained a good set <strong>of</strong> needed<br />
preparations (microscope slides and macro-preparations) for teaching<br />
medical parasitology.<br />
7. We have started with utilisation <strong>of</strong> computer-aided learning and teaching<br />
methods. Students have possibilities to use computerised classrooms to<br />
study existing teaching materials in Estonian (produced by lecturers <strong>of</strong> our<br />
chair) and textbooks in English.<br />
Medical Genetics<br />
1. As was already said above due to general changes in medical curriculum<br />
<strong>the</strong>re was a 2- years break in teaching “Medical Genetics” to medical students.<br />
It was also decided to bring teaching <strong>of</strong> “Medical Genetics “ to <strong>the</strong><br />
5 th year <strong>of</strong> studium. Quite recently <strong>the</strong> course was renamed as “ Human<br />
molecular and clinical genetics” and <strong>the</strong> teaching amount raised from<br />
2CP to 4 credit points. The studium will start in automn <strong>of</strong> 2001 with lecture<br />
course (42 hours), and with practical works in spring (54 hours).<br />
2. In spring 2001 we also start teaching (2 CP) <strong>of</strong> “Medical Genetics” to stomatology<br />
students as one part <strong>of</strong> “Children stomatology”. The course will<br />
consist <strong>of</strong> 16 hours <strong>of</strong> lectures, and 32 hours <strong>of</strong> practical works.<br />
3. From <strong>the</strong> academic year 2000/2001 we’ll use for teaching rooms in <strong>the</strong><br />
new building <strong>of</strong> Biomedicum with good equipment. The halls for lectures<br />
have all technical equipment for teaching (data projectors, PCs, overheads,<br />
videos). For practical teaching we have already equipment for PCR, electrophoresis,<br />
gene analysis, etc. So <strong>the</strong> students can do individual work in<br />
human molecular genetics, as it was already introduced by us in 1999 in<br />
our old teaching rooms. Now, naturally, <strong>the</strong> students will work with better<br />
equipment in better rooms.<br />
4. In addition to above-mentioned literature sources <strong>the</strong>re is available in<br />
Internet teaching aid in molecular genetics prepared by assistant Gunna<br />
Tasa: http://biomedicum.ut.ee/~gtasa/prax.html .<br />
5. A booklet for “ Chromosome aberrations” is in preparation by docent Ruth<br />
Mikelsaar.<br />
3. Describe <strong>the</strong> strengths and weaknesses <strong>of</strong> <strong>the</strong> teaching in your department.<br />
Strengths<br />
Biology<br />
1. As <strong>the</strong> strengths <strong>of</strong> <strong>the</strong> curriculum <strong>of</strong> “Biology”, <strong>the</strong> students considered its<br />
interesting and wide-ranging subjects, and that completing <strong>the</strong> curriculum<br />
provides a strong <strong>the</strong>oretical basis.<br />
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160<br />
2. The scientific orientation <strong>of</strong> <strong>the</strong> curriculum and its correspondence to <strong>the</strong><br />
curricula <strong>of</strong> leading universities <strong>of</strong> Scandinavia as well in <strong>the</strong> United States<br />
gives <strong>the</strong> students who have completed <strong>the</strong>ir studies on diploma level at<br />
<strong>the</strong> Faculty <strong>of</strong> Medicine <strong>of</strong> <strong>the</strong> University <strong>of</strong> Tartu <strong>the</strong> chance to continue<br />
<strong>the</strong>ir studies elsewhere in <strong>the</strong> world.<br />
3. The teaching staff is well trained and motivated. They are ready to accept<br />
new technologies and respond to <strong>the</strong> feedback given by students.<br />
4. Use <strong>of</strong> new building <strong>of</strong> Biomedicum with good equipment makes possible<br />
to utilize computer-aided learning and teaching methods.<br />
Medical Genetics<br />
1. As <strong>the</strong> most important strength <strong>of</strong> <strong>the</strong> curriculum <strong>of</strong> “ Medical Genetics”<br />
(now “ Human molecular and clinical genetics”) we think is <strong>the</strong> scientific<br />
orientation <strong>of</strong> teaching, and that <strong>the</strong> staff is well trained not only in <strong>the</strong>orethical<br />
medical genetics, but also has a long-time practical experience.<br />
Pr<strong>of</strong>. Aavo-Valdur Mikelsaar (over 30 years) and docent Ruth Mikelsaar<br />
(over 20 years) have real practice in medico-genetical consultation <strong>of</strong> patients;<br />
assistant Gunnar Tasa is already many years active in forensic molecular<br />
genetic paternity diagnostics and person identification.<br />
2. We think that our second strength is that we have succeeded sufficiently<br />
enlarge <strong>the</strong> possibilities for medical students to get practical experience in<br />
computer-aided genetic syndrome diagnostics, and in practical works in<br />
human molecular genetics: <strong>the</strong>y have now possibilities to do many interesting<br />
works with <strong>the</strong>ir own hands.<br />
3. The third strength is also that every student has <strong>the</strong> possibility to at least<br />
see how does modern equipment for gene sequencing, protein analysis,<br />
etc., more active student can take part in scientific work.<br />
Weaknesses<br />
Biology:<br />
1. The stucture <strong>of</strong> <strong>the</strong> Biomedicum building makes impossible to provide class<br />
works with smaller groups. Rooms for practicums are planned for 24 student.<br />
Rooms are in use by different courses, not only by “Biology”. Rooms<br />
with equal equipment, needed for teaching <strong>of</strong> “Biology”, are absent.<br />
2. The teaching staff is too small for possible works with smaller groups.<br />
Medical Genetics<br />
1. As for “Biology” <strong>the</strong> structure <strong>of</strong> <strong>the</strong> Biomedicum building makes impossible<br />
to provide class works with smaller groups. Rooms for practicums are<br />
planned for 24 student. Rooms are in use by different courses, not only by<br />
“Medical Genetics”.
4. Describe <strong>the</strong> innovations in your teaching.<br />
BIOLOGY AND GENETICS<br />
Biology<br />
1. During last 2 years computer-aided teaching methods have been introduced<br />
as a complement to traditional teaching methods.<br />
2. Different textbooks (in Estonian) for parts <strong>of</strong> course “Biology” have been<br />
produced. Some <strong>of</strong> <strong>the</strong>m are available for students through Internet.<br />
3. According our recommendation our libraries have obtained 20 copies <strong>of</strong><br />
textbook <strong>of</strong> B.Alberts et al.:”Molecular biology <strong>of</strong> <strong>the</strong> cell” and some different<br />
textbooks in biology.<br />
Medical Genetics<br />
1. During 1996-1999 computer-aided teaching methods had been introduced<br />
as a complement to traditional teaching methods. Now starting 2001 this<br />
experience will be enlarged.<br />
2. Some teaching materials from our staff are already available for students<br />
through Internet.<br />
5. <strong>Name</strong> <strong>the</strong> factors which most disturb teaching (exluding financial resources).<br />
Biology<br />
1. First-year students are not ready to work independently.<br />
2. Groups <strong>of</strong> practicums are too large (24 students) and one assistant (<strong>the</strong><br />
head <strong>of</strong> <strong>the</strong> chair have found no possibilities to direct a person for technical<br />
help) is not able to work with students individually.<br />
3. First-year students are not ready to use English textbooks.<br />
4. A number <strong>of</strong> students from Russian secondary schools are not able to<br />
communicate in Estonian, although <strong>the</strong>y had high marks in state examination<br />
in Estonian language.<br />
5. The system where lecturer have one teaching-free semester during election<br />
period for scientific or pedagogical work does not work.<br />
Medical Genetics<br />
1. The most disturbing factor in <strong>the</strong> development <strong>of</strong> teaching in “Medical Genetics”<br />
has been frequent changes in general medical curriculum bringing<br />
teaching <strong>of</strong> this subject from 6 th year studium to <strong>the</strong> 3 rd year studium, and<br />
again to <strong>the</strong> 5 th year studium. Now <strong>the</strong> staff and <strong>the</strong> students do agree that<br />
this last change is possibly <strong>the</strong> best one.<br />
2. We think that <strong>the</strong> o<strong>the</strong>r concrete disturbing factors will be clear after starting<br />
again “Medical Genetics” for stomatology students this spring, and<br />
“Human molecular and clinical genetics” to medical students in fall <strong>of</strong> 2001.<br />
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II. EVALUATION OF TEACHING<br />
6. How is <strong>the</strong> quality <strong>of</strong> <strong>the</strong> teaching in your department evaluated? How are<br />
<strong>the</strong> content and <strong>the</strong> modes <strong>of</strong> <strong>the</strong> teaching changed on <strong>the</strong> basis <strong>of</strong> evaluation?<br />
Biology<br />
1. A systematic questionnaire-based student evaluation has been carried out<br />
at <strong>the</strong> end or after passing <strong>of</strong> <strong>the</strong> course. The form used is prepared by <strong>the</strong><br />
Deans´ Office and includes questions <strong>of</strong> <strong>the</strong> quality <strong>of</strong> individual teachers,<br />
lecturers, practical classes, textbooks etc. Unfortunately, <strong>the</strong> response<br />
were not distributed to teaching staff during last years.<br />
2. Analogical questionnaire-based evaluation has been carried out by <strong>the</strong><br />
Estonian Medical Students´ Assotiation. Results <strong>of</strong> <strong>the</strong>se evaluations have<br />
been published in <strong>the</strong> students´ journal “Curare”<br />
(http://www.ut.ee/eays/ee.htm).<br />
162<br />
3. The teaching staff have periodically analysed current situation in teaching<br />
process. Result <strong>of</strong> <strong>the</strong>se analysis was an introduction <strong>of</strong> computer-aided<br />
teaching methods and publishing <strong>of</strong> textbooks for practicums.<br />
Medical Genetics<br />
A questionnaire-based evaluation has been carried with <strong>the</strong> aid <strong>of</strong> <strong>the</strong> 6 th and<br />
3 rd years students 4 years ago, and practically all <strong>of</strong> <strong>the</strong>m wrote that <strong>the</strong> subject<br />
was very interesting and necessary for medical students, but <strong>the</strong> 6 th year<br />
is too late as <strong>the</strong> students are already finishing diploma studium, and <strong>the</strong> 3 rd<br />
year is too early as <strong>the</strong> students do not now many medical termins, and do not<br />
have knowledge in basic human diseases. So mainly on basis <strong>of</strong> <strong>the</strong>se opinions<br />
it was proposed to bring <strong>the</strong> teaching <strong>of</strong> this subject to <strong>the</strong> 5 th year.<br />
Genetics<br />
No special evaluation has been done.<br />
III. PEDAGOGIC TRAINING OF STAFF<br />
7. How many <strong>of</strong> <strong>the</strong> teachers have received pedagogic training?<br />
Biology<br />
Two assistents from <strong>the</strong> teaching staff <strong>of</strong> “Biology” (4 persons) have passed a<br />
formal course <strong>of</strong> pedagogics during <strong>the</strong>ir studies in university and have graduated<br />
as teachers <strong>of</strong> biology and chemistry for high-class secondary school<br />
(senior high school or gymnasium).<br />
O<strong>the</strong>r teachers are graduated Medical Faculty or teorethical branch (nonpedagogical)<br />
<strong>of</strong> Biological Faculty.
BIOLOGY AND GENETICS<br />
One assistant have passed 4 years ago a special course <strong>of</strong> distance education<br />
management (FEUCODE II, FEUTUTOR, University <strong>of</strong> Tartu and University <strong>of</strong><br />
Helsinki).M<br />
Medical Genetics<br />
All teachers are graduated from Medical Faculty, and have not passed any<br />
special pedagogic training. Never<strong>the</strong>less <strong>the</strong>y have a long practical experience<br />
in this field (see p.3).<br />
8. Is <strong>the</strong>re a need for fur<strong>the</strong>r pedagogic training?<br />
Biology<br />
There are no formal courses for teachers and lecturers in pedagogics. The<br />
possible reason for this is <strong>the</strong> fact, that <strong>the</strong> Faculty <strong>of</strong> pedagogics in Tartu University<br />
is under formation just now.<br />
We believe that teaching skills <strong>of</strong> our staff are reasonably good. Additional<br />
pedagogical training is beneficial.<br />
Medical Genetics<br />
We believe that teaching skills <strong>of</strong> our staff are reasonably good, but an additional<br />
pedagogical training is always beneficial.<br />
IV. TEACHING RESOURCES<br />
9. Is <strong>the</strong>re a need for rearrangement <strong>of</strong> <strong>the</strong> teaching resources in your department?<br />
If so, how should this be done?<br />
Biology<br />
2 persons for technical help during practicums are needed.<br />
V. COORDINATION OF THE TEACHING<br />
10. How is <strong>the</strong> teaching co-ordinated with o<strong>the</strong>r departments? Indicate <strong>the</strong> departments<br />
that are closest to your department.<br />
Biology<br />
As it was described in previous parts subject “Biology” (6 CP) is tightly coordinated<br />
with subject “General histology and embryology” (2 CP) in <strong>the</strong><br />
frames <strong>of</strong> “Medical biology I” (8 CP).<br />
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164<br />
Subject “Biology” is a basement for most biological subjects passed by students<br />
later (Physiology, Pathology, Microbiology, Biochemistry, Medical Genetics,<br />
Obstetrics and Gynecology, Pharmacology, Public Health, Internal<br />
Medicine).<br />
Medical Genetics<br />
The teaching <strong>of</strong> medical genetics is tightly co-ordinated with biology, histology<br />
and embryology, biochemistry, pathology, and with different clinical subjects.<br />
VI. FUTURE PLANS<br />
11. Future plans to improve <strong>the</strong> teaching given by <strong>the</strong> department.<br />
Biology<br />
1. Both <strong>the</strong> content and methods <strong>of</strong> teaching will develope continously. To<br />
consider particularities <strong>of</strong> our 1st year students <strong>the</strong> balance between <strong>the</strong><br />
lectures and class works must be not changed. Computer-aided teaching<br />
will be developed and its usefulness carefully evaluated.<br />
2. There is a serious need to change <strong>the</strong> system <strong>of</strong> admission into Faculty<br />
pupils from Russian language secondary schools. It is up to <strong>the</strong> Faculty to<br />
organize a system for checking <strong>the</strong> knowledge <strong>of</strong> Estonian language and to<br />
guarantee, if it is necessary, <strong>the</strong>ir participation in Estonian language intensive<br />
course before <strong>the</strong> full time studies.<br />
3. The teaching staff <strong>of</strong> “Biology” is interested to get feedback from questionnaire-based<br />
student evaluations after passing <strong>of</strong> course. For this we plan to<br />
introduce an independent questionnaire.<br />
4. The technical base <strong>of</strong> teaching (preparations, videos, PCs, s<strong>of</strong>tware) needs<br />
modernization. We also hope that <strong>the</strong> situation where 4 teachers must use<br />
3 working places and 2 PC will be changed.<br />
Medical Genetics<br />
1. As was already said above it has been decided to bring teaching <strong>of</strong><br />
“Medical Genetics “ to <strong>the</strong> 5 th year <strong>of</strong> studium. Quite recently it was also<br />
decided to rename <strong>the</strong> course as “Human molecular and clinical genetics”<br />
and raise <strong>the</strong> teaching amount from 2 CP to 4 credit points. The studium<br />
will start in automn <strong>of</strong> 2001 with lecture course (42 hours), and with<br />
practical works in spring (54 hours). In spring 2001 we also start teaching<br />
(2 CP) <strong>of</strong> “Medical Genetics” to stomatology students as one part <strong>of</strong> “Children<br />
stomatology”. The course will consist <strong>of</strong> 16 hours <strong>of</strong> lectures, and 32<br />
hours <strong>of</strong> practical works.<br />
2. Taking into consideration <strong>the</strong> changes in <strong>the</strong> amount <strong>of</strong> teaching for medical<br />
students, and a new course for stomatology students <strong>the</strong>re is a great<br />
need in <strong>the</strong> better technical base <strong>of</strong> teaching (preparations, videos, PCs,<br />
s<strong>of</strong>tware). We must pay more attention to <strong>the</strong> preparation <strong>of</strong> written aid<br />
materials for students.
BIOLOGY AND GENETICS<br />
Human Biology and Genetics: resource evaluation<br />
1. Study materials<br />
- How many study books are published in your institution during last five years? 2<br />
- Do you have separate room as library in your place? Yes No<br />
- Could students borrow study books from your institution? Yes No<br />
- Do you have on-line published study materials for students? Yes No<br />
- WWW address: http://biomedicum.ut.ee<br />
- Does University library has enough modern books in your speciality?<br />
Completely enough Enough Scarcely Absolutely scarcely No<br />
2. Amount and size <strong>of</strong> study rooms<br />
- Rooms used by Your institution only: 18 rooms with area <strong>of</strong> 345,9 m 2<br />
- Rooms shared with ano<strong>the</strong>r institution: 4 rooms with area <strong>of</strong> 67.6 m 2<br />
- Do You have enough space for study process by Your opinion?<br />
Completely enough Enough Scarce Absolutely scarcely<br />
- How <strong>the</strong> scarce <strong>of</strong> space should be handled or changed?<br />
New building Change to smaller student groups Better logistics<br />
O<strong>the</strong>r way (describe shortly)<br />
3. Current situation <strong>of</strong> study rooms<br />
- There has been repairments in last years (except Biomedicum)<br />
- How are <strong>the</strong> study rooms lightened?<br />
Very good Good Some darkness Absolutely dark for study<br />
- Evaluation <strong>of</strong> general conditions: Very good Good Satisfactory Bad<br />
4. Your institution has<br />
a) 2 (how many?) auditorium(s) for workshops/seminars with 70 and 170 places, equipped<br />
with<br />
Blackboard<br />
White board & markers<br />
Screen<br />
Overhead projector<br />
Data projector<br />
Slide projector<br />
b) 1 (how many?) laboratories for practicals with 24 places, equipped with<br />
Blackboard<br />
White board and markers<br />
Screen<br />
Overhead projector<br />
Data projector<br />
Slide projection kit<br />
TV/Video projection set<br />
Computer<br />
Internet connection<br />
TV/Video projection kit<br />
Computer<br />
Internet connection<br />
5. Working rooms for teaching staff and postgraduate students:<br />
- Number <strong>of</strong> teaching staff 8<br />
- Number <strong>of</strong> rooms for staff 5<br />
- Number <strong>of</strong> individual working places 7, among <strong>the</strong>m with computers 7<br />
- Number <strong>of</strong> postgraduate students is 5<br />
- How many individual working places <strong>the</strong>y have? 2<br />
- How many computers <strong>the</strong>y have? 2<br />
6. O<strong>the</strong>r comments on resource topic (max 250 letters):<br />
165
SECTION I: APPENDIXES<br />
APPENDIX I-I<br />
Visits <strong>of</strong> <strong>the</strong> Chair members to o<strong>the</strong>r institutions abroad during 1996-2000<br />
Year Researcher/Lectures Institution Country Purpose Duration<br />
1981 Raivo Masso,docent University <strong>of</strong> Bratislava Slovakia Research 10 months<br />
1990 Aleksander Adojaan,assistant University <strong>of</strong> Kuopia Finland Research 2 weeks<br />
1995 Erkki Juronen University <strong>of</strong> Lund Sweden Training 1 week<br />
1995 Raivo Masso,docent University <strong>of</strong> Umea Sweden Reseach 3 weeks<br />
1996 Juronen Erkki,sen.researcher ESHG UK Conference 1 week<br />
1996 Mikelsaar, Aavo-Valdur,pr<strong>of</strong>. ESHG London Conference 1 week<br />
1996 Mikelsaar, Ruth, docent ESHG London Conference 1 week<br />
1996 Raivo Masso,docent University <strong>of</strong> Umea Sweden Reseach 5 weeks<br />
1996 Tasa Gunnar,assistant ESHG UK Conference 1 week<br />
1996 Valdmann Andres, researcher Norwegian School <strong>of</strong> Veterinary<br />
Sciences<br />
Norway Training 3 months<br />
1996 Valdmann Andres, researcher Australia congress 1 week<br />
1997 Mikelsaar, Ruth, docent Austria Conference 1 week<br />
1997 Miklesaar, Ruth, docent ESHG Italy Conference 1 week<br />
1997 Miklesaar,Aavo-Valdur, pr<strong>of</strong>. ESHG Italy Conference 1 week<br />
1997 Piirsoo Andres, Sr researcher University <strong>of</strong> Mainz Germany Training 6 weeks<br />
1997 Valdmann Andres, researcher Norwegian School <strong>of</strong> Veterinary<br />
Sciences<br />
Norway Training 2 months<br />
1998 Mikelsaar, Aavo-Valdur,pr<strong>of</strong>. ESHG Portugal Conference 1 week<br />
1998 Mikelsaar, Ruth, docent University <strong>of</strong> Dresden Germany Training 1 week<br />
1998 Mikelsaar, Ruth, docent ESHG Portugal Conference 1 week<br />
1998 Raivo Masso,docent University <strong>of</strong> Umea Sweden Reseach 4 weeks<br />
1998 Tasa Gunnar,assistant Italy Conference 1 week<br />
1998 Valdmann Andres, researcher Norwegian School <strong>of</strong> Veterinary<br />
Sciences<br />
Norway Training 3 months<br />
1998 Valdmann Andres, researcher University <strong>of</strong> Veterinary Sciences<br />
Hungary Training 1 week<br />
1998 Valdmann Andres, researcher Finland congress 1 week<br />
1999 Mikelsaar, Aavo-Valdur,pr<strong>of</strong>. ESHG Switzerland Conference 1 week<br />
1999 Mikelsaar, Aavo-Valdur,pr<strong>of</strong>. VilniusUniversity Lithuania Conference 1 week<br />
1999 Mikelsaar, Ruth, docent ESHG Switzerland Conference 1 week<br />
1999 Mikelsaar, Ruth, docent Sweden Conference 1 week<br />
1999 Mikelsaar, Ruth, docent Vilnius University Lithuania Conference 1 week<br />
1999 Mikelsaar, Ruth, docent Poland Conference 1 week<br />
1999 Valdmann Andres, researcher Norwegian School <strong>of</strong> Veterinary<br />
Sciences<br />
Norway Training 1 month<br />
1999 Valdmann Andres, researcher Kaunas Veterinary Academy Lithuania Lectures 1 week<br />
2000 Mikelsaar, Aavo-Valdur, pr<strong>of</strong>. ESHG Holland Conference 1 week<br />
2000 Mikelsaar, Ruth, docent ESHG Holland Conference 1 week<br />
2000 Miklesaar, Ruth, docent Jointed Laboratory Finland Research 3 weeks<br />
2000 Raivo Masso,docent University <strong>of</strong> Umea Sweden Reseach 1 week<br />
2000 Valdmann Andres, researcher Norwegian Veterinary School Norway Training 1 month<br />
2000 Valdmann Andres, researcher Sweden Congress 1 week<br />
2000 Valdmann Andres, researcher Swedish University <strong>of</strong> Agricyltural<br />
Sciences<br />
166<br />
Sweden Training 1 week
APPENDIX I-II<br />
BIOLOGY AND GENETICS<br />
Postgraduate students at <strong>the</strong> <strong>Department</strong> having studied abroad during 1996-2000<br />
Year <strong>Name</strong> Institution Contry Duration<br />
1998 Andress Valdmann Norwegian School <strong>of</strong> Veterinary Science Norway 3 months<br />
1998 Andress Valdmann University <strong>of</strong> Veterynary Science Hungary 1 week<br />
1999 Andress Valdmann Norwegian School <strong>of</strong> Veterinary Science Norway 1 month<br />
APPENDIX I-III<br />
Co-operation with institutions from o<strong>the</strong>r countries and participation in international<br />
research projects during 1996-2000<br />
Contact person Institution Country Aim<br />
Raivo Masso, docent University <strong>of</strong> Umea Sweden Research<br />
Raivo Masso, docent University <strong>of</strong> Umea Sweden Research<br />
Andres Piirsoo,sen.researcher University <strong>of</strong> Mainz Germany Research<br />
Andres Valdmann, researcher Norwegian School <strong>of</strong> Veterinary Science Norway Research<br />
Ruth Mikelsaar,docent United Laboratories,Helsinki Finland Research<br />
Ruth Mikelsaar,docent University <strong>of</strong> Dresden,Technical Institute Germany Research<br />
Ruth Mikelsaar,docent University <strong>of</strong> Zürich Switzerland Research<br />
Aavo-Valdur Mikelsaar University <strong>of</strong> Umea Sweden Research<br />
Aavo-Valdur Mikelsaar Cedars Sinai Medical USA Research<br />
APPENDIX I-IV<br />
Visiting lecturers at <strong>the</strong> <strong>Department</strong> during 1996-2000<br />
Visitor Institution Country Purpose <strong>of</strong> <strong>the</strong> Visit<br />
Gunnar Selstam,pr<strong>of</strong>. University <strong>of</strong> Umea Sweden Research<br />
Pr<strong>of</strong>. Lars-Eric Thornell University <strong>of</strong> Umea Sweden Research<br />
Pertti Aula University <strong>of</strong> Turku Finland Research<br />
Albert Schinzel University <strong>of</strong> Zürich Switzerland Research<br />
H.H.Goebel University <strong>of</strong> Mainz Germany Research & training<br />
APPENDIX I-V<br />
Scientific journals available at <strong>the</strong> Chair<br />
No <strong>Name</strong> <strong>of</strong> Journal Version<br />
1. European Journal <strong>of</strong> Human Genetics paper<br />
167
SECTION I: APPENDIXES<br />
APPENDIX I-V<br />
Publications <strong>of</strong> <strong>the</strong> <strong>Department</strong> members during 1996-2000<br />
MONOGRAPHS<br />
1. Mikelsaar Ruth. Etiological Factors <strong>of</strong> Diseases in Genetically Consulted Children and Newborn<br />
Screening. Dissertation <strong>of</strong> Doctor <strong>of</strong> Medical Sciences. University <strong>of</strong> Tartu, 1993.<br />
2. M. Viikmaa. Eestlaste populatsioonigeneetiline uurimine geneetiliste distantside ja klasteranalüüsi<br />
abil. Magistritöö geneetikast, 18 lk + 2 artiklikoopiat. Tartu Ülikool 1998.<br />
3. Waldmann A. Studies on progesterone in bovine milk. Immunoanalysis, distribution in <strong>the</strong> mammary<br />
gland and influence at first insemination on fertility <strong>of</strong> dairy cows. Doctoral <strong>the</strong>sis. Estonian<br />
Agricultural University, Tartu 1999, 158 pp.<br />
4. Waldmann A. Piima progesteroonisisalduse määramismeetodite võrdlus ja kasutamine lehmade<br />
sigimisseisundi kindlakstegemiseks: Magistriväitekiri. - Tartu: Eesti Põllumajandusülikooli<br />
Loomaarstiteaduskond ja Tartu Ülikooli Üld- ja Molekulaarpatoloogia Instituut, 1997. - 67 lk.<br />
PAPERS IN INTERNATIONAL JOURNALS<br />
1. Juronen, E., Tasa, G., Uusküla, M., Pooga, M. and Mikelsaar, A.-V. (1996) Producing and characterization<br />
<strong>of</strong> monoclonal antibodies against class Theta glutathione S-transferase T1-1. Hybridoma<br />
15, 77-82.<br />
2. Juronen, E., Tasa, G., Uusküla, M., Pooga, M. and Mikelsaar, A.-V. (1996) Purification, characterization<br />
and tissue distribution <strong>of</strong> human class Theta glutathione S-transferase T1-1. Biochem. Mol.<br />
Biol. Int. 39 (1), 21-29.<br />
3. Tasa, G., Juronen, E., Viikmaa, M., Tiidla, A., Pärlist, P., Uusküla, M., Kalev, I. and Mikelsaar, A.-V.<br />
(1996) Distribution <strong>of</strong> glutathione S-transferase T1 phenotypes in <strong>the</strong> Estonian population. Gene<br />
Geography 10 (3), 181-189.<br />
4. Mikelsaar Ruth V.-A., Lurie J.W., Ilus T.E. Pure partial trisomy 4q25-qter owing to a de novo 4;22<br />
translocation. Journal <strong>of</strong> Medical Genetics, London 1996;33:344-345.<br />
5. Pähkla R., Masso R., Zilmer M., Rägo L., Airaksinen M.M.: Autoradiographic localization <strong>of</strong> ( 3 H)pinoline<br />
binding sites in mouse tissues. - Meth. Find. Exp. Clin. Pharmacol., 1996, vol. 18, 6, p. 359<br />
- 366.<br />
6. T.Remmel,A.Piirsoo,A.,A.Kõiveer,H.Remmel,R.Uibo,V.Salupere Clinical significance <strong>of</strong> different<br />
antinuclear antibodies patterns in <strong>the</strong> course <strong>of</strong> primary biliary cirrhosis.Hepato-Gastroenterology<br />
1996,43,1135-1140.<br />
7. Pähkla R., Masso R., Rägo L., Airaksinen M.M.: ( 3 H)-pinoline binding sites: autoradiographic visualization<br />
and characterization. - Acta Medica Baltica, 1996, vol.3, 3, p. 218 - 226.<br />
8. M.Maimets, A.Krüüner, A. Adojaan: Antibiotic resistance in clinical specimens from <strong>the</strong> Tartu Lung<br />
Clinic, 2nd Nordic-Baltic Congress on Infectious Diseases, Proceedings: “Prevention in Focus”,<br />
Riga, 02-03.05.1996, p. 33-34.<br />
9. A.Arend, R.Masso, M.Masso: Indomethacin and prostaglandin E1 administration suppress labelled<br />
amino-acid incorporation into cells from rat regenerating connective tissue: evidence <strong>of</strong> labelled<br />
amino-acid incorporation into lipid bodies in <strong>the</strong> cells from <strong>the</strong> wound area. - In: The 3rd Workshop<br />
<strong>of</strong> <strong>the</strong> Veterinary Medicine Anatomists <strong>of</strong> <strong>the</strong> Baltic and Nordic Countries (12,13 and 14 September),<br />
Proceedings, Tartu, Estonia, 1996, p.7 –13.<br />
10. Veromann S. Expression <strong>of</strong> an eye lens fiber membrane protein (MP26) in some non-lens tissues.<br />
The III Workshop <strong>of</strong> <strong>the</strong> Veterinary Medicine Anatomists <strong>of</strong> <strong>the</strong> Baltic and Nordic Countries, 12, 13<br />
and 14 September. Papers <strong>of</strong> <strong>the</strong> Conference. Tartu, 1996:85-87.<br />
11. Veitch, J.M., Murray, G.I., Juronen, E., Kilty, C.G., Doyle, S., Hawksworth, G.M. and Rodilla, V.<br />
(1997) Theta-class glutathione S-transferase in human kidney and renal tumors. Biochemical Society<br />
Transactions 25, 605.<br />
12. Vlachodimitropoulos, D., Norppa, H., Autio, K., Catalan, J., Hirvonen, H., Tasa, G., Uusküla, M.,<br />
Demopoulos, N.A. and Sorsa, M.. (1997) GSTT1-dependent induction <strong>of</strong> centromere-negative and<br />
-positive micronuclei by 1,2:3,4-diepoxybutane in cultured human lymphocytes. Mutagenesis 12<br />
(5), 397-403.<br />
13. Konovalova G., Masso R., Ööpik V., Viru A.: Significance <strong>of</strong> thyroid hormones in postexercise incorporation<br />
<strong>of</strong> amino acids into muscle fibers in rats: an autoradiographic study. - Endocrinology<br />
and Metabolism, 1997, vol. 4, 1, p. 25 – 31.<br />
14. H.H. Goebel , A.Piirsoo, I. Warlo, O.Sch<strong>of</strong>fer Infantile intranuclear rod myopathy.J.<strong>of</strong> Child Neurology<br />
1997,12, 1,22-30.<br />
168
BIOLOGY AND GENETICS<br />
15. S.Ingerpuu, A.Piirsoo, A.Sünter, A.Pihlak MC29.1 Myeloid antigens functional studies: carbohydrate-<br />
specific monoclonal antibody M19 (IGR-2 1A6) initiates myeloid cell homotyping aggregation.<br />
In Leucocyte Typing VI, Ed.by Kishimoto T et al. , N-Y,1997, 1092-1094.<br />
16. Mikelsaar Ruth V., Zordania R., Viikmaa M., Kudrjavtseva G. Neonatal screening for congenital<br />
hypothyroidism in Estonia. Journal <strong>of</strong> Medical Screening, London 1998;5(1):20-21.<br />
17. T.Klaassen, M.Teder, M.Viikmaa, A. Metspalu. Neonatal screening for cystic fibrosis main mutation<br />
)F508 in Estonia. – J. Medical Screening, 1998, 5: 16-19.<br />
18. Beckman L., Sikstrom C., Mikelsaar A.-V., Krumina A., Ambrasiene D., Kucinskas V., Beckman G.<br />
Transferrin variants as markers <strong>of</strong> migration and admixture between populations in <strong>the</strong> Baltic Sea<br />
region. Human Heredity 1998, 48(4): 185-191.<br />
19. Kurg, R., Parik, J., Juronen, E., Sedman, T., Abroi, A., Liiv, I., Langel, Ü. and Ustav, M. (1999) Effect<br />
<strong>of</strong> bovine papillomavirus E2 protein-specific monoclonal antibodies on papillomavirus DNA<br />
replication. J. Virol. 73 (6), 4670-4677.<br />
20. Beckman L., Sikstrom C., Mikelsaar A., Krumina A., Kucinskas V., Beckman G. Alpha 1-antitrypsin<br />
(PI) alleles as markers <strong>of</strong> Westeuropean influence in <strong>the</strong> Baltic Sea region. Human Heredity 1999,<br />
49(1): 52- 55.<br />
21. Ü.A. Talkop, T. Klaassen, A. Piirsoo, V.Sander, A. Napa, E.Essenson, J.Tammur, T.Talvik Duchenne<br />
and Becker muscular dystrophies: an Estonian experience.Brain & Development 21,244-<br />
247,1999.<br />
22. Waldmann A. 1999. Monoclonal antibodies to progesterone: production and selection for enzyme<br />
immunoassay (EIA) in bovine milk. Hybridoma 18, 289-296.<br />
22. Waldmann A., Ropstad E., Landsverk K., Sørensen K., Sølverød L., Dahl E.1999. Level and distribution<br />
<strong>of</strong> progesterone in bovine milk in relation to <strong>the</strong> storage in <strong>the</strong> mammary gland. Animal Reproduction<br />
Science 56, 79-91.<br />
23. G.Selstam, R.Masso, A.Arend, M.Masso, M.Aunapuu: Light and electron microscope immunocytochemical<br />
localization <strong>of</strong> cyclooxygenase 1 and 2 in corpus luteum <strong>of</strong> pregnant and pseudopregnant<br />
rat. In: 4th Baltic- Nordic Workshop in Veterinary Anatomy, Proceedings, Oslo, June 4-6, 1999,<br />
p. 57-62.<br />
24. A.Arend, R.Masso, M.Masso, M.Aunapuu, H.Tomusk: Lipid bodies as intracellular sites <strong>of</strong> prostaglandin<br />
formation in <strong>the</strong> cells <strong>of</strong> rat liver wound. In: 4th Baltic- Nordic Workshop in Veterinary Anatomy,<br />
Proceedings, Oslo, June 4-6, 1999, p. 11-13.<br />
25. Juronen, E., Tasa G., Veromann, S., Parts, L., Tiidla, A., Pulges, R., Panov, A., Soovere, L., Koka,<br />
K. and Mikelsaar, A.-V. (2000) Polymorphic glutathione S-transferases as genetic risk factors for<br />
senile cortical cataract in Estonians. Invest. Ophthalmol. Vis. Sci. 41, 2262_2267.<br />
26. Juronen, E., Tasa G., Veromann, S., Parts, L., Tiidla, A., Pulges, R., Panov, A., Soovere, L., Koka,<br />
K. and Mikelsaar, A.-V. (2000) Polymorphic glutathione S-transferase M1 is a risk factor <strong>of</strong> primary<br />
open-angle glaucoma among Estonians. Exp. Eye Res. 71 (5), 447-452.<br />
27. Zoë H. Rosser, Tatiana Zerjal, Mat<strong>the</strong>w E. Hurles, Maarja Adojaan, Dragan Alavantic, António<br />
Amorim, William Amos, Manuel Armenteros, Eduardo Arroyo, Guido Barbujani, Gunhild<br />
Beckman, Lars Beckman, Jaume Bertranpetit, Elena Bosch, Daniel G. Bradley, Gaute Brede,<br />
Gillian Cooper, Helena B. S. M. Côrte-Real, Peter de Knijff, Ronny Decorte, Yuri E. Dubrova,<br />
Oleg Evgrafov, Anja Gilissen, Sanja Glisic, Mukaddes Gölge, Emmeline W. Hill, Anna Jeziorowska,<br />
Luba Kalaydjieva, Manfred Kayser, Toomas Kivisild, Sergey A. Kravchenko, Astrida Krumina,<br />
Vaidutis Kuinskas, João Lavinha, Ludmila A. Livshits, Patrizia Malaspina, Syrrou Maria, Ken<br />
McElreavey, Thomas A. Meitinger, Aavo-Valdur Mikelsaar, R. John Mitchell, Khedoudja Nafa,<br />
Jayne Nicholson, Søren Nørby, Arpita Pandya, Jüri Parik, Philippos C. Patsalis, Luísa Pereira,<br />
Borut Peterlin, Gerli Pielberg, Maria João Prata, Carlo Previderé, Lutz Roewer, Siiri Rootsi,<br />
D. C. Rubinsztein, Juliette Saillard, Fabrício R. Santos, Gheorghe Stefanescu, Bryan C. Sykes, Aslihan<br />
Tolun, Richard Villems, Chris Tyler-Smith, and Mark A. Jobling: Y-Chromosomal Diversity in<br />
Europe Is Clinal and Influenced Primarily by Geography, Ra<strong>the</strong>r than by Language . Amer.J.Human Genetics,<br />
67:1526-1543, 2000.<br />
28. Mikelsaar Ruth V., Viikmaa M.. Neonatal Thyroid-Stimulating Hormone Screening as an Indirect<br />
Method for <strong>the</strong> Assessment <strong>of</strong> Iodine Deficiency in Estonia. Hormone Research 1999;52:284-286<br />
(Released July 2000).<br />
29. Kulla A., Liigant A.,Piirsoo A.,Rippin G., Asser T. Tenascin expression patterns and cells <strong>of</strong> monocyte<br />
lineage: relationship in human gliomas.Modern Pathology 2000,13,1,56-67.<br />
30. Waldmann A. Studies on progesterone in bovine milk. An overview. Feeding, metabolism and infections<br />
in farm animals with special reference to reproduction. Proceedings from symposium at<br />
Estonian Agricultural University, Tartu, February 24-25, 2000. B. Aasmäe, T. Tiirats and U. Magnusson<br />
(editors), Centre for Reproductive Biology in Uppsala Report 11, Uppsala 2000, pp. 52-59.<br />
169
SECTION I: APPENDIXES<br />
31. Waldmann A., A. Kureoja, T. Kaart, A. Tiidla, O. Saveli. On <strong>the</strong> factors affecting commencement <strong>of</strong><br />
postpartum luteal activity in Estonian dairy cows. Proceedings <strong>of</strong> <strong>the</strong> 6th Baltic Animal Breeding<br />
Conference. Jelgava 27-28 April 2000, pp 23-27.<br />
32. Mikelsaar Ruth V., Varb K., Süvari A., Schinzel A. Mosaic terminal del(19)(q13.33:) in a girl with<br />
seizures and mental retradation. Letter to <strong>the</strong> Editor. Journal <strong>of</strong> Medical Genetics (London)<br />
2001;37:E2.<br />
33. Waldmann A., Reksen, O., Landsverk K., Kommisrud, E., Dahl E., Refsdal, A.O., Ropstad E. 2001.<br />
Progesterone concentrations in milk fat at first insemination-effects on non-return and repeatbreeding.<br />
Animal Reproduction Science 65, 33-41.<br />
PAPERS IN ESTONIAN JOURNALS.<br />
1. Mikelsaar Ruth, Kudrjavtseva G., Viikmaa M. Kaasasündinud hüpotüreoosi sõeluuring Eestis.<br />
Eesti Arst 1998;3:195-198.<br />
2. A.Adojaan, M.Masso: Toksokariasis (review article, in Estonian.) Eesti Arst, 2000, 4: 216 - 221.<br />
3. Sünter, A. Piirsoo Põletikuvalkude kompleks, MRP8/MRP14 võimaliku kliinilise markerina. Eesti<br />
Rohuteadlane 1997, 68-69.<br />
4. Ö. Sünter, J. Parik, Ü. Ani, A. Piirsoo.igetel.Eesti<br />
Rohuteadlane 1997, 69. A. Piirsoo, H. Leesik, A. Kõiveer. Morfoloogilised muutused<br />
astmahaigete bronhikoes Eesti rohuteadlane 1997, 43-44.<br />
5. Ü.A.Talkop,A.Napa,H. Sibul, A.Piirsoo, V.Sander , M.Salk, I.Talvik,M.Hämarik,A.Sööt,<br />
A.Metspalu,T.Talvik Edusammud Duchenne’I ja Beckeri tüüpi lihasdüstro<strong>of</strong>ia diagnoosimisel Eestis.<br />
Eesti Arst 1999,3,201-208.<br />
6. A.Talkop,M.Sõnajalg,A.Paves,H.Sibul,A.Piirsoo,T.Talvik.Kardiomüopaatia Duchenne’I ja Beckeri<br />
tüüpi lihasdüstro<strong>of</strong>iaga lastel .Eesti Arst 1999,2,107-110.<br />
7. M. Viikmaa. Kui palju keelt on geneetilises keeles? – Schola bio<strong>the</strong>oretica XXII, Elu keeled. Eesti<br />
Teaduste Akadeemia kirjastus, Tartu-Tallinn, 1996, lk. 58-62.<br />
8. M. Viikmaa, L. Heapost. Genetic differentiation <strong>of</strong> Estonians. – Proc. Estonian Acad. Sci. Biol. 45,<br />
¾, 1996, lk.128-136.<br />
9. M. Viikmaa. Evolutsioonilised perspektiivid sõltuvalt populatsioonide suurusest ja liigendatusest. –<br />
Schola bio<strong>the</strong>oretica XXIII, Metapopulatsioonide teooria. Eesti Teaduste Akadeemia kirjastus,<br />
Tartu, 1997, lk. 46-47.<br />
10. M. Viikmaa. Mendel 175: hernehübriididest transgeenideni. – XX Eesti looduseuurijate päev. Eesti<br />
looduseuurimine uue sajandi vahetusel. Eesti Teaduste Akadeemia kirjastus, Tartu, 1997, lk. 55-<br />
60.<br />
11. M. Viikmaa. Prioonid – iseäralikud haigusetekitajad. – Eesti Loomaarstlik Ringvaade, 23, 4, 1997,<br />
lk. 163-173.<br />
12. M. Viikmaa. Prioon ei ole enam mõistatus. – Eesti Loomaarstlik Ringvaade, 23, 4, 1997, lk. 162-<br />
163.<br />
13. M. Viikmaa. Neoteenia: hominisatsiooni paradoksi lahendus? – Schola bio<strong>the</strong>oretica XXIV, Ontogenees<br />
ja fülogenees. OÜ Sulemees, Tartu, 1998, lk. 109-117.<br />
14. Ruth Mikelsaar, G.Kudrjavtseva, M.Viikmaa. Kaasasündinud hüpotüreoosi sõeluuring Eestis. –<br />
Eesti Arst, 3, 1998, lk. 195-198.<br />
15. L.Heapost, M.Viikmaa. Anthropological and population genetic characterisation <strong>of</strong> <strong>the</strong> Estonians. –<br />
Folia Baeriana VII. Tartu, 1999, lk. 98-115.<br />
16. M. Viikmaa. Geneetiline mälu. – Schola bio<strong>the</strong>oretica XXV, Biosüsteemide mälu teooria. OÜ Sulemees,<br />
Tartu, 1999, lk. 27-32.<br />
17. M. Viikmaa. Kohasus ehk genotüübi adaptiivväärtus. – Schola bio<strong>the</strong>oretica XXVI, Adaptatsiooni<br />
teooria. OÜ Sulemees, Tartu, 2000, lk. 22-29.<br />
18. Veromann S, TasaG, Viikmaa M, Jüri P, Pulges R, Panov A, Koka K, Soovere L, Juronen E, Tiidla<br />
A, Paju K: Vanaduskatarakti riskifaktorid. Ülevaade; Eesti Arst, Nr. 5, :272-279; 2000.<br />
19. Veromann S. Miks silmalääts on valgurikkaim kude organismis? Schola Bio<strong>the</strong>oretica XXVl, Tartu,<br />
lk. 53-56;2000.<br />
20. Waldmann A., A. Kureoja, T. Kaart, A. Tiidla, O. Saveli. Luteaalse aktiivsuse taastumisest Eesti<br />
piimalehmadel. EAPS Toimetised 12, lk 105-108, Tartu 2000.<br />
21. Aluvee A., Kolk A., Ploom L., Püssa T., Waldmann A. Saasteainete jääkainete seire loomsetes<br />
toiduainetes. - Akadeemilise Põllumajanduse Seltsi toimetised 7, Tartu 1998, 5-8.<br />
22. Waldmann A. Progesteroonisisaldus täispiimas ja lõssis sõltuvalt piima päritolust piimanäärmes.<br />
Veterinaarmeditsiin ’98, 17.-19. September, Tartu 1998, lk 61-70.<br />
23. Waldmann A. Piima progesteroonisisalduse määramine. Ülevaade. - Eesti Loomaarstlik<br />
Ringvaade, 1996, 3, 99-115.<br />
170
SUBMITTED PAPERS<br />
BIOLOGY AND GENETICS<br />
1. Reksen O., Gröhn Y.T., Havrevoll, Ø., Bolstad T., Waldmann, A., Ropstad E. Influence <strong>of</strong> energy<br />
balance and concentrate allocation on post partum ovarian activity in moderate yielding, dual<br />
purpose cows. Journal <strong>of</strong> Dairy Science (in press).<br />
2. Mikelsaar Ruth V., Muru K., Varb K., Süvari A., Kulla A. Psoriasis vulgaris in a Male With Partial<br />
Deletion 18p.<br />
3. Arend, G. Selstam, M. Soom, I. Kolts, R. Masso, Ü. Arend: Prostaglandins <strong>of</strong> <strong>the</strong> E-series inhibit<br />
connective tissue proliferation in <strong>the</strong> liver wound <strong>of</strong> <strong>the</strong> rat, Journal <strong>of</strong> Pharmacological and Toxicological<br />
Methods.<br />
4. Veromann S., Juronen E., Tasa G.: A simple, rapid and useful Coomassie blue staining <strong>of</strong> histological<br />
sections. J. Histochem.;<br />
5. Reksen O., Gröhn Y.T., Havrevoll, Ø., Bolstad T., Waldmann, A., Ropstad E. Relations between<br />
milk constituents and post partum ovarian activity in moderate yielding, dual purpose cows.<br />
(submitted).<br />
6. Reksen O., Gröhn Y.T., Havrevoll, Ø., Bolstad T., Waldmann, A., Ropstad E. Relationships among<br />
milk progesterone, concentrate allocation, energy balance, milk yield and conception rate in<br />
moderate yielding cows. (submitted).<br />
TEXTBOOK AND MANUALS<br />
1. R. Masso, A. Saag, M. Masso, U. Kokassaar: “Bioloogia praktikum I” (“Practicums in biology I”, in<br />
Estonian), õppevahend arstiteaduskonna üliõpilastele, Tartu Ülikool, Üld- ja molekulaarpatoloogia<br />
instituut, Tartu Ülikooli Kirjastuse trükikoda, 1997, 83 lk.<br />
2. R. Masso, A. Saag, M. Masso, U. Kokassaar, I. Kalev: “Bioloogia praktikum II” (“Practicums in biology<br />
II”, in Estonian), õppevahend arstiteaduskonna üliõpilastele, Tartu Ülikool, Üld- ja molekulaarpatoloogia<br />
instituut, Tartu Ülikooli Kirjastuse trükikoda, 1998, 169 lk.<br />
3. R. Masso, A. Saag, M. Masso, U. Kokassaar: “Bioloogia praktikum I” (“Practicums in biology I”, in<br />
Estonian),, õppevahend arstiteaduskonna üliõpilastele, Tartu Ülikool, Üld- ja molekulaarpatoloogia<br />
instituut, Tartu Ülikooli Kirjastuse trükikoda, 1999, teine parandatud trükk, 83 lk.<br />
4. R. Masso, A. Saag, M. Masso, U. Kokassaar, I. Kalev: “Bioloogia praktikum II” (“Practicums in biology<br />
II”, in Estonian),, õppevahend arstiteaduskonna üliõpilastele, Tartu Ülikool, Üld- ja molekulaarpatoloogia<br />
instituut, Tartu Ülikooli Kirjastuse trükikoda, 1999, teine parandatud trükk, 169 lk.<br />
5. T.Alamäe, K.Kull, U.Kõljalg, R.Masso, M.Ustav: “Bioloogia gümnaasiumidele” (“Biology for gymnasium”<br />
in Estonian), II osa, Eesti Loodusfoto, Tartu, 2000, 95 lk.<br />
6. T.Alamäe, K.Kull, U.Kõljalg, R.Masso, M.Ustav: “Biologija dlja gimnazii” (“Biology for gymnasium”<br />
in Russian), II tšast, Eesti Loodusfoto, Tartu, 2000, 96 lk.<br />
171
APPENDIX I-VII<br />
Academic and administrative personnel: Chair <strong>of</strong> Human Biology and Genetics<br />
BIOLOGY AND GENETICS<br />
<strong>Name</strong> Title Load Area Gender Birth year Scientific degree Year <strong>of</strong> commencement Labour time (y)<br />
1. Mikelsaar Aavo-Valdur Pr<strong>of</strong>essor 1,00 Human biology and genetics Male 1941 Cand.Sci & Dr.sci 1970 & 1980 35<br />
2. Masso Raivo Docent 1,00 Cell biology Male 1948 Cand.Sci 1980 28<br />
3. Mikelsaar Ruth Docent 1,00 Medical genetics Female 1941 Cand.Sci & Dr.med 1980 & 1993 20<br />
4. Tasa Gunnar Assistant 0,50 Medical genetics Male 1965 9<br />
5. Uusküla Mart Assistant 0,50 Medical genetics Male 1965 9<br />
6. Masso Marika Assistant 1,00 Cell biology Female 1962 15<br />
7. Adojaan Aleksander Assistant 1,00 Experimental medicine Male 1954 Cand.Sci 1991 20<br />
8. Saag Anu Assistant 1,00 Cell biology Female 1956 21<br />
9. Piirsoo Andres Sr. researcher 1,00 Cell biology Male 1948 Cand.Sci 1981 28<br />
10. Veroman Siiri Sr. researcher 1,00 Cell biology Female 1938 Cand.Sci 1971 38<br />
11. Juronen Erkki Sr. researcher 1,00 Immunogenetics and -chemistry Male 1959 Cand.Sci 1988 18<br />
12. Valdmann Andres Researcher 0,50 Immunogenetics and -chemistry Male 1961 Dr.Sci 1997 & 1999 9<br />
13. Viikmaa Mart Researcher 0,50 Human biology and genetics Male 1938 M.Sci 1998 38<br />
14. Sünter Alar Researcher 1,00 Cell biology Male 1962 M.Sc 1998 11<br />
15. Laiverik Rei Engineer 1,00 Male 1948 18<br />
16. Laisk Tiiu Secretary 1,00 Female 1937 38<br />
17. Pärlist Pire Sr. Technical staff 1,00 Female 1959<br />
18. Kõiveer Anu Sr. Technical staff 1,00 Female 1957 11<br />
19. Remmelkoor Sr. Technical staff 1,00 Female 1965<br />
20. Sünter Ööle Sr. Technical staff 1,00 Female 1964<br />
21. Tiidla Anne Sr. Technical staff 1,00 Female 1958<br />
22. Sinijärv Urmas Technical staff 0,50 Male<br />
23. Varb Kadi Technical staff 1,00 Female 1976 3<br />
24. Mikelsaar Technical staff 1,00 Male 1968 5<br />
25. Mikelsaar Technical staff 1,00 Male 1943 18<br />
1 Cand.Sci & Dr.Sci are degrees <strong>of</strong> <strong>the</strong> Former Soviet Union which correspond to a Ph.D and Dr.Med, respectively<br />
173
APPENDIX I-VIII<br />
Curriculum Vitae <strong>of</strong> <strong>the</strong> staff<br />
BIOLOGY AND GENETICS<br />
MIKELSAAR, AAVO-VALDUR Date <strong>of</strong> birth: 26 th <strong>of</strong> July 1941 Gender: male Citizenship: Estonian Address:<br />
Anne str. 51-34 , Tartu 50703, ESTONIA Educational history: graduated from <strong>the</strong> Medical<br />
Faculty <strong>of</strong> Tartu University, 1965, physician postgraduate studium in <strong>the</strong> Institute <strong>of</strong> Molecular Biology,<br />
U.S.S.R., Academy <strong>of</strong> Sciences, Moscow, 1967-1970 studium in Austria, University <strong>of</strong> Vienna, 1976-<br />
1977 1-month studium in Tampere University, 1988 3-months studium in Medical University <strong>of</strong> Luebeck,<br />
1993 Academic degrees (with year and university): candidate <strong>of</strong> medical sciences; Academy <strong>of</strong><br />
Medical Science, U.S.S.R., 1970 doctor <strong>of</strong> biology; Academy <strong>of</strong> Medical Sciences, U.S.S.R., 1980<br />
Employment and pr<strong>of</strong>essional experience: University <strong>of</strong> Tartu, jun. researcher, 1965- 1967 Postgraduate<br />
student, Moscow, 1967-1970 Researcher, head <strong>of</strong> laboratory, Tartu University, 1970-1987<br />
Pr<strong>of</strong>essor <strong>of</strong> human biology and genetics, since 1993 Administrative experience: director <strong>of</strong> <strong>the</strong> Institute<br />
<strong>of</strong> General and Molecular Pathology, Tartu University, since 1987 Honours and awards: -<br />
Membership in academic and scientific societies: European Society <strong>of</strong> Human Genetics; Estonian<br />
Society <strong>of</strong> Human Genetics; New York Academy <strong>of</strong> Sciences Current research program and grants:<br />
Generation <strong>of</strong> monoclonal antibodies against fibronectin is<strong>of</strong>orms and development <strong>of</strong> diagnostic kits.<br />
Grant <strong>of</strong> ESF, no.3249 The study <strong>of</strong> multifactorial diseases using genetic, cytological and molecular<br />
markers. Supervision <strong>of</strong> dissertations: successfully defended 6 dissertations ( 4 cand.<strong>of</strong> sciences, 1<br />
magister, 1 doctor <strong>of</strong> sciences). At moment under supervision 4 doctorands. Publications: 140<br />
MASSO, RAIVO Date <strong>of</strong> birth: 05.12.1948 Gender: male Citizenship: Estonian Address: Mõisavahe<br />
39-60, Tartu, Estonia Educational history: Faculty <strong>of</strong> Biology <strong>of</strong> Tartu University as geneticist (1972)<br />
Academic degrees (with year and university): Cand. Sc. in physiology, Tartu University, 1980 Employment<br />
and pr<strong>of</strong>essional experience: 1972 – 1981 reseacher and senior reseacher in Laboratory<br />
for Researches <strong>of</strong> Hormonal Bases <strong>of</strong> Muscular Activity, Faculty <strong>of</strong> Physical Education, Tartu University;<br />
1981 – 1982 senior reseacher in Institute <strong>of</strong> General and Molecular Pathology, Tartu University;<br />
1982 – 1991 senior lecturer and docent in <strong>Department</strong> <strong>of</strong> Genetics and Cytology, Faculty <strong>of</strong> Biology<br />
and Geography, Tartu Unuversity; 1991 – 2001 docent in <strong>Department</strong> <strong>of</strong> General and Molecular Pathology,<br />
Faculty <strong>of</strong> Medicine, Tartu University. Administrative experience: - no Honours and awards<br />
- no Membership in academic and scientific societies: member <strong>of</strong> <strong>the</strong> Morphological Society <strong>of</strong><br />
Estonia Current research program and grants: grant no. 1406 from Estonian Science Foundation<br />
(1995 – 1996); Supervision <strong>of</strong> dissertations: 2 Publications: 72, at Medline level – 10.<br />
MIKELSAAR, RUTH Date <strong>of</strong> birth: 11 th <strong>of</strong> April 1941 Gender: female Citizenship: Estonian Address:<br />
Anne str. 51-34 , Tartu 50703, ESTONIA Educational history: graduated from <strong>the</strong> Medical Faculty <strong>of</strong><br />
Tartu University, 1966, physician 2-months studium in Moscow University, in medical genetics, 1974<br />
2-months studium in Moscow University, in medical genetics, 1977 2-weeks (1984) and 2-weeks<br />
(1989) studiums in Summer Schools in Lithuania, in genetics 3-months studium in Medical University<br />
<strong>of</strong> Luebeck, in genetics, 1993 1.5-weeks studium in Technical University <strong>of</strong> Dresden, in genetics, 1998<br />
3-weeks research in Jointed Laboratory in Helsinki, 2000 Academic degrees (with year and university):<br />
candidate <strong>of</strong> medical sciences, in genetics, Academy <strong>of</strong> Medical Science, U.S.S.R., 1980 doctor<br />
<strong>of</strong> medical sciences, University <strong>of</strong> Tartu, 1993 Employment and pr<strong>of</strong>essional experience: Tartu Republic<br />
Psychoneurological Hospital, head <strong>of</strong> laboratory, 1966-1981 University <strong>of</strong> Tartu, jun. researcher,<br />
1981- 1987 University <strong>of</strong> Tartu, reseacher 1987-1993 University <strong>of</strong> Tartu sen. researcher, head <strong>of</strong><br />
Human Genetics Laboratory, 1993-1998 University <strong>of</strong> Tartu, dozent <strong>of</strong> human biology and genetics,<br />
head <strong>of</strong> Human Genetics Laboratory, since 1998 Administrative experience: head <strong>of</strong> Human Genetics<br />
Laboratory <strong>of</strong> <strong>the</strong> Institute <strong>of</strong> General and Molecular Pathology, Tartu University, since 1993<br />
Honours and awards: - Membership in academic and scientific societies: European Society <strong>of</strong><br />
Human Genetics European Cytogenetic Association International Society <strong>of</strong> Neonatal Screening Estonian<br />
Society <strong>of</strong> Human Genetics Current research program and grants: Genetic, epidemiologic and<br />
preventive study in mental retardation. Grant <strong>of</strong> ESF, no.3025, The study <strong>of</strong> multifactorial diseases<br />
using genetic, cytological and molecular markers. Supervision <strong>of</strong> dissertations: At moment under<br />
supervision 1 doctorand, 4 residents and 1 student. Publications: 80<br />
MASSO, MARIKA Date <strong>of</strong> birth: 14.05.1962 Gender: female Citizenship: Estonian Address: Mõisavahe<br />
39-60, Tartu, Estonia Educational history: Faculty <strong>of</strong> Biology <strong>of</strong> Tartu University as biologist<br />
(cytologist) (1985) Academic degrees (with year and university): M.Sc. Tartu University, 1985 Employment<br />
and pr<strong>of</strong>essional experience: 1985 – 1991 laboratory assistant, <strong>Department</strong> <strong>of</strong> Genetics<br />
and Cytology, Faculty <strong>of</strong> Biology, Tartu University; 1991 – 1992 laboratory assistant, <strong>Department</strong> <strong>of</strong><br />
General and Molecular Pathology, Faculty <strong>of</strong> Medicine, Tartu University; 1992 – 2001 assistant in De-<br />
175
SECTION I: APPENDIXES<br />
partment <strong>of</strong> General and Molecular Pathology, Faculty <strong>of</strong> Medicine, Tartu University. Administrative<br />
experience: - no Honours and awards - no Membership in academic and scientific societies: no<br />
Current research program and grants: no Supervision <strong>of</strong> dissertations: no Publications: 14<br />
ALEKSANDER ADOJAAN Date <strong>of</strong> birth: 06.12.1954 Gender: male Citizenship: Estonian Address: Välja<br />
4-48, Tallinn, Estonia Educational history: Faculty <strong>of</strong> Medicine <strong>of</strong> Tartu University as physician<br />
(1979) Academic degrees (with year and university): Cand. Sc. in medicine, Tartu University, 1991<br />
Employment and pr<strong>of</strong>essional experience: 1980 – 1991 reseacher in Institute <strong>of</strong> General and Molecular<br />
Pathology, University <strong>of</strong> Tartu; 1991 – 2001 assistant in <strong>Department</strong> <strong>of</strong> General and Molecular<br />
Pathology, Faculty <strong>of</strong> Medicine, Tartu University. Administrative experience: - no Honours and<br />
awards - no Membership in academic and scientific societies: no Current research program and<br />
grants: no Supervision <strong>of</strong> dissertations: no Publications: 20, at Medline level – 5.<br />
SAAG, ANU Date <strong>of</strong> birth: 14.09.1956 Gender: female Citizenship: Estonian Address: Kungla 46,<br />
Tartu, Estonia Educational history: Faculty <strong>of</strong> Biology <strong>of</strong> Tartu University as geneticist (1979) Academic<br />
degrees (with year and university): M.Sc., Tartu University 1979 Employment and pr<strong>of</strong>essional<br />
experience: 1979 – 1991 assistant in <strong>Department</strong> <strong>of</strong> Genetics and Cytology, Faculty <strong>of</strong> Biology,<br />
Tartu University; 1991 –2001 assistant inf <strong>Department</strong> <strong>of</strong> General and Molecular Pathology, Faculty<br />
<strong>of</strong> Medicine, Tartu University. Administrative experience: - no Honours and awards - no Membership<br />
in academic and scientific societies: member <strong>of</strong> <strong>the</strong> Society <strong>of</strong> Estonian Genetics Current<br />
research program and grants: no Supervision <strong>of</strong> dissertations: no Publications: 1<br />
TASA, GUNNAR Date <strong>of</strong> birth: 10th <strong>of</strong> February 1965 Gender: male Citizenship: Estonian citizen Address:<br />
Ravila 19, Tartu 51014, Estonia Educational history: graduated from Medical Faculty <strong>of</strong> Tartu<br />
University at 1991. Academic degrees: - Employment and pr<strong>of</strong>essional experience: 1991-… researcher<br />
and assistant at <strong>the</strong> <strong>Department</strong> <strong>of</strong> Human Biology and Genetics 2000-... Expert <strong>of</strong> molecular<br />
genetics at Estonian Bureau <strong>of</strong> Forensic Medicine Administrative experience: - Honours and<br />
awards: - Membership in academic and scientific societies: - Current research program and<br />
grants: Polymorphic glutathione S-transferases GSTM3, GSTP1 and GSTZ1 in Estonians and possible<br />
connections with susceptibility to diseases Molecular mechanisms <strong>of</strong> <strong>the</strong> gelatinous drop-like corneal<br />
dystrophy Relation <strong>of</strong> depression and suicide to serotonin transporter gene polymorphism Association<br />
<strong>of</strong> intelligence and personality traits with genetic markers Supervision <strong>of</strong> dissertations: -<br />
Publications: 12.<br />
UUSKÜLA, MART 2. Date <strong>of</strong> birth: 27.05.1965 3. Gender: Male Citizenship: Estonian Address: Riia 7-<br />
3 51010 Tartu, Estonia 6. Educational history: Tartu 2 secondary school 1982, University <strong>of</strong> Tartu,<br />
medical faculty 1991 7. Academic degrees: - 8. Employment and pr<strong>of</strong>essional experience: 1991-<br />
1995 postgraduate student and researcher, Institiute <strong>of</strong> General and Molecular Pathology (IGMP),<br />
1996- 0.5 assistant , IGMP 9. Administrative experience: - 10. Honours and awards: - 11. Membership<br />
in academic and scientific societies: - 12. Current research program and grants: - 13. Supervision<br />
<strong>of</strong> dissertations: - ‘<br />
PIIRSOO, ANDRES Date <strong>of</strong> birth: September, 24, 1948 Gender: man Citizenship: Estonian Address:<br />
Hermanni11-1, Tartu, 51005,Estonian Republic Educational history: University <strong>of</strong> Tartu, 1967-1972(<br />
Biology) Institute <strong>of</strong> Developmental Biology , Academy <strong>of</strong> Science <strong>of</strong> Soviet Union, Moscow 3months<br />
in 1972 Center <strong>of</strong> Cardiology,Academy <strong>of</strong> Medical Science <strong>of</strong> Soviet Union, Moscow, 3months in 1982<br />
NIH, Baltimore,USA 10 months in 1986/87 7. Academic degrees : diploma <strong>of</strong> biologist ( correspond to<br />
Master <strong>of</strong> Science), University <strong>of</strong> Tartu candidate <strong>of</strong> science ( histology-embryology)( correspond to<br />
PhD.) Institute <strong>of</strong> Developmental Biology Academy <strong>of</strong> Science <strong>of</strong> Sovit Union, Moscow Certificate <strong>of</strong><br />
Associate Pr<strong>of</strong>essor gave by Higher Certification Comission, Moscow 8. Employment and pr<strong>of</strong>essional<br />
experience: till now assistant, senior lecturer, associate pr<strong>of</strong>essor,head <strong>of</strong> <strong>the</strong> laboratory, senior<br />
scientist, University <strong>of</strong> Tartu I have pr<strong>of</strong>essional experience in <strong>the</strong> following fields <strong>of</strong> biology and<br />
biomedicine: cell differentiation, monoclonal antibodies research, immuno- and electron microscopy<br />
diagnostics ( especially human muscle diseases). 9. Administrative experience: no 10.Honours and<br />
awards: no 11.Membership in academic and scientific societies: member <strong>of</strong> <strong>the</strong> Estonian Society<br />
<strong>of</strong> Morfology and Estonian Society <strong>of</strong> Human Genetics 12.Current research programm and grants:<br />
Monoclonal antibodies to human inflammatory cell proteins Electron microscopic diagnostics <strong>of</strong> human<br />
muscle disease and human metabolic storage disease. The value <strong>of</strong> diagnostic electronmicroscopic<br />
ultrastructural markers evaluation in different tissue and cell pathological cases – grant application for<br />
2001-3003 13. Supervisor <strong>of</strong> dissertation: 3 PhD dissertation, 1 Master <strong>of</strong> Science dissertation 14.<br />
Publications in 1996-2000 : 7 articles and 10 <strong>the</strong>ses <strong>of</strong> conferences<br />
176
BIOLOGY AND GENETICS<br />
VEROMANN, SIIRI Date <strong>of</strong> birth 1938, 29th <strong>of</strong> April Gendre Female Citizenship Estonian AdressRavila<br />
Str. 19, Room 2091, Tartu 51014, Estonia Educational history Graduated Tartu University 1962<br />
Academic degrees Cand. Biol. 1971, Tartu University Employment and pr<strong>of</strong>essional experience<br />
Since 1962 – to 1975 – researcer, from 1975 on – senior researcer <strong>of</strong> Institute <strong>of</strong> General and Molecular<br />
Pathology, Tartu University Administrative experience- Honors and awards Estonian science<br />
award 1995 Membership in academic and scientific societies Society <strong>of</strong> Estonian Anatomists,<br />
Histologists and Embryologists Current research program and grantsCataractogenesis and glaucoma<br />
development, grant no 4457 <strong>of</strong> Estonian Science Foundation Supervision <strong>of</strong> dissertations- Publications<br />
Articles : 8 (indexed in CC); 16 (in Russian), 3 (in Estonian); (not exactly counted, excuse me)<br />
Theses: in Russian, English and Estonian – not counted, very sorry.<br />
JURONEN, ERKKI Date <strong>of</strong> birth: 24.02.59. Gender: male Citizenship: Estonian Address: 51014 Tartu,<br />
Ravila 72-1 Educational history: University <strong>of</strong> Tartu, <strong>Department</strong> <strong>of</strong> Biology, ichtyologisthydrobiologist<br />
in 1982 Academic degrees: Canditate <strong>of</strong> biological science degree in molecular biology<br />
from University <strong>of</strong> Tartu in 1988 Employment and pr<strong>of</strong>essional experience: 1982-1986 researcher<br />
in University <strong>of</strong> Tartu, IGMP; 1986-1988 postgraduate student in molecular biology in University<br />
<strong>of</strong> Tartu; 1988-1993 head <strong>of</strong> Laboratory <strong>of</strong> Immunoanalysis in University <strong>of</strong> Tartu; since 1993 senior<br />
researcher in University <strong>of</strong> Tartu, Institute <strong>of</strong> General and Molecular Pathology, <strong>Department</strong> <strong>of</strong> Human<br />
Biology and Genetics Administratiev experience: - Honours and awards: - Membership in academic<br />
and scientific societies: - Current research program and grants: Grant 4349 from Estonian<br />
Science Foundation Supervision <strong>of</strong> dissertations: - Publications: 19<br />
VALDMANN, ANDRES Date <strong>of</strong> birth:05.12.1961 Gender: Male Citizenship: Estonian Address: Kreutzwaldi<br />
38-14, 51006 Tartu, Estonia Educational history: 1985: DVM, Faculty <strong>of</strong> Veterinary Medicine,<br />
Estonian Academy <strong>of</strong> Agriculture. 1985 - 1990: Estonian Research Institute <strong>of</strong> Animal Breeding and<br />
Veterinary Science, postgraduate studies. Academic degrees: 1997: Master <strong>of</strong> Veterinary Science,<br />
Estonian Agricultural University. 1999: Doctor <strong>of</strong> Veterinary Science, Estonian Agricultural University.<br />
Employment and pr<strong>of</strong>essional experience: 1985 - 1986 and 1988 - 1990: junior research scientist,<br />
Estonian Research Institute <strong>of</strong> Animal Breeding and Veterinary Science. 1990 - 1994: research scientist,<br />
Estonian Research Institute <strong>of</strong> Animal Breeding and Veterinary Science. 1991-: research scientist,<br />
Institute <strong>of</strong> General and Molecular Pathology, University <strong>of</strong> Tartu. 1995 - 1999: research scientist, <strong>Department</strong><br />
<strong>of</strong> Reproductive Biology, Estonian Agricultural University. 2000 -: senior research scientist,<br />
<strong>Department</strong> <strong>of</strong> Reproductive Biology, Estonian Agricultural University. -hybridoma technology -<br />
immunoassay methodology -physiology and endocrinology <strong>of</strong> <strong>the</strong> reproductive process in <strong>the</strong> dairy<br />
cow -mammary gland physiology. Administrative experience: Vice President, Estonian Veterinary<br />
Association (1994-1997). Honours and awards: 1996: Young Scientist Award from <strong>the</strong> Organising<br />
Committee <strong>of</strong> <strong>the</strong> 13th International Congress on Animal Reproduction. Membership in academic<br />
and scientific societies: Estonian Academic Society <strong>of</strong> Agriculture (1994 - ). International Congress<br />
on Animal Reproduction (ICAR, Member <strong>of</strong> <strong>the</strong> Standing Committee 1996-). European Society for<br />
Domestic Animal Reproduction (ESDAR, country representative, 1998 -). Current research program<br />
and grants 2001 - 2004: Factors limiting fertility in Estonian dairy cattle, Estonian Science Foundation,<br />
principal investigator. Dissertations advised: Publications: -.1 MS (1997) and 1 dissertation (1999)<br />
Articles with peer referee: 4, 2 in press, 2 submitted Abstracts with peer referee: 6 Articles without<br />
referee: 18 Abstracts without referee: 1<br />
SÜNTER, ALAR Date <strong>of</strong> birth: 08. August 1962 Gender : Male Citizenship: Estonian Address: 44 - 12<br />
Kaunase str., Tartu, Estonia Educational history: 1998 University <strong>of</strong> Tartu, magister <strong>of</strong> biomedicine ;<br />
1983 - 1988 University <strong>of</strong> Tartu, department <strong>of</strong> Biology and Geography. Diploma in cytology and histology<br />
; 1981 - 1983 soviet army ; 1977 - 1980 Secondary School in Kingissepa, speciality in ma<strong>the</strong>matics<br />
and physics. Academic degrees: 1988 bacalaureus in cytology and histology (University <strong>of</strong><br />
Tartu); 1998 magister in biomedicine (University <strong>of</strong> Tartu) Employment and pr<strong>of</strong>essional experience:<br />
1989 - 1993 University <strong>of</strong> Tartu, Institute <strong>of</strong> General and Molecular Pathology, junior researcher;<br />
1993 - present University <strong>of</strong> Tartu Institute <strong>of</strong> General and Molecular Pathology, researcher. Administrative<br />
experience: Honours and awards: Membership in academic and scientific societies: Current<br />
research program and grants: Supervision <strong>of</strong> dissertations:1988 Diploma on <strong>the</strong> <strong>the</strong>me: "<br />
Human blood neutrophil specific monoclonal antibodies"; 1998 magister dissertation on <strong>the</strong> <strong>the</strong>me "<br />
Investigation <strong>of</strong> inflammatory markerproteins MRP8 and MRP14 and <strong>the</strong>ir complexes using monoclonal<br />
antibodies" Publications: 5 articles, 2 conference <strong>the</strong>ses.<br />
VIIKMAA, MART Date <strong>of</strong> birth: September 4, 1938 Gender: male Citizenship: estonian Address:<br />
Aardla Street 9A-85, Tartu, Estonia Educational history: Tartu University (TU), department <strong>of</strong> biology,<br />
1962 Postgraduate student study in zoology in TU, 1965 Academic degrees: Magister scienti-<br />
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SECTION I: APPENDIXES<br />
arum (MSc) in genetics, TU, 1998 Employment and pr<strong>of</strong>essional experience: 1965 – junior researcher<br />
in Central Medical Laboratory <strong>of</strong> TU 1968 – assistant in chair <strong>of</strong> genetics and darwinism <strong>of</strong><br />
TU 1972 – senior lecturer in chair <strong>of</strong> genetics and cytology <strong>of</strong> TU – senior researcher in IGMP <strong>of</strong> TU,<br />
laboratory <strong>of</strong> human genetics 1992 – senior researcher (0.5) in chair <strong>of</strong> human biology and genetics,<br />
faculty <strong>of</strong> medicine docent (0.5) in chair <strong>of</strong> genetics, faculty <strong>of</strong> biology and geography) 1999 – researcher<br />
(0.5) in chair <strong>of</strong> human biology and genetics lecturer (0.5) in chair <strong>of</strong> genetics Administrative<br />
experience: head <strong>of</strong> laboratory <strong>of</strong> human genetics in IGMP, 1982-1987 Honours and awards: ‘Eesti<br />
eluteaduse hoidja’ from Esonian Society <strong>of</strong> Nature Researches , 1984 Membership in academic and<br />
scientific societies: Estonian Society <strong>of</strong> Nature Researches Estonian Society <strong>of</strong> Human Genetics<br />
European Anthropological Association Grants: Population genetics, human biology, <strong>the</strong>oretical biology;<br />
partition in grants No. 2967 and 3025 from ESF Supervision <strong>of</strong> dissertations: -- Publications:<br />
total number: 114, in international journals: 9<br />
178
PATHOPHYSIOLOGY<br />
<strong>Name</strong> <strong>of</strong> <strong>the</strong> <strong>Department</strong>: <strong>Department</strong> <strong>of</strong> General and Molecular Pathology<br />
Head <strong>of</strong> <strong>the</strong> <strong>Department</strong>: Pr<strong>of</strong>essor Aavo-Valdur Mikelsaar<br />
<strong>Name</strong> <strong>of</strong> <strong>the</strong> Chair: Pathophysiology<br />
Head <strong>of</strong> <strong>the</strong> Chair: Pr<strong>of</strong>essor Enn Seppet<br />
Subject codes: ARMP.03.006; ARMP.03.008; ARMP.03.015;<br />
ARMP.03.016; ARMP.03.016<br />
I. CONTENT OF THE TEACHING<br />
1. Describe shortly <strong>the</strong> main study and student evaluation methods applied at<br />
<strong>the</strong> department.<br />
The objective <strong>of</strong> pathophysiology is to teach medical students to understand<br />
<strong>the</strong> etiology and pathogenesis <strong>of</strong> <strong>the</strong> syndromes and diseases at <strong>the</strong> level <strong>of</strong><br />
organism, organ, tissue, cell and molecules. The specific emphasize is put not<br />
on learning <strong>the</strong> morphological alterations but on reflecting <strong>the</strong> physiologic<br />
changes that produce signs and symptoms as well as compensatory mechanisms.<br />
Pathophysiology is teached within <strong>the</strong> “Pathology” block toge<strong>the</strong>r with<br />
pathological anatomy on 5 th term. The course <strong>of</strong> pathophysiology comprises<br />
64 hours <strong>of</strong> lectures and 64 hours <strong>of</strong> practicals /seminars with a total volume <strong>of</strong><br />
5.5 credit points (5.5 weeks <strong>of</strong> work). In <strong>the</strong> lectures <strong>the</strong> students are acquainted<br />
with <strong>the</strong> concepts <strong>of</strong> general pathological processes and dysfunction<br />
<strong>of</strong> <strong>the</strong> organ systems. The students are provided with <strong>the</strong> relevant materials for<br />
self-learning. The practicals are devoted to accomplish <strong>the</strong> laboratory/experimental<br />
studies in order to learn <strong>the</strong> methods and results <strong>of</strong> scientific<br />
work in <strong>the</strong> Chair <strong>of</strong> Pathophysiology, to investigate <strong>the</strong> clinical material (blood<br />
tests, urine analyses and muscle specimen) from patients with different diseases,<br />
and to perform some experiments on laboratory animals. During seminars<br />
<strong>the</strong> students are requested to analyse <strong>the</strong> cases and slides describing <strong>the</strong><br />
mechanisms underlying <strong>the</strong> pathological processes, symptoms and syndromes.<br />
In this process <strong>the</strong> students are asked to explore <strong>the</strong> following domains:<br />
hypo<strong>the</strong>sis generation, analysis and syn<strong>the</strong>sis <strong>of</strong> <strong>the</strong> information, definition<br />
<strong>of</strong> learning issues, application <strong>of</strong> newly acquired knowledge in order to<br />
formulate decisions and tasks for fur<strong>the</strong>r self-learning.<br />
The work <strong>of</strong> students is evaluated throughout <strong>the</strong> course in a form <strong>of</strong> three<br />
tests in which <strong>the</strong> students have to write essays on <strong>the</strong> topic required. The<br />
positive marks in all three tests are prerequisites to be allowed to take <strong>the</strong><br />
written exam.<br />
2. How <strong>the</strong> aims and objectives described in <strong>the</strong> curriculum changed during<br />
<strong>the</strong> past five years?<br />
Teaching in pathophysiology has been reformed two years ago. The major<br />
changes undertaken in <strong>the</strong> curriculum are:<br />
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180<br />
1. The number <strong>of</strong> auditorial work hours is decreased in order to allocate more<br />
time for individual self-learning. Compared to earlier volume <strong>of</strong> 7.2 credit<br />
points <strong>the</strong> new volume <strong>of</strong> <strong>the</strong> program equals to 5.5 credit points.<br />
2. The content <strong>of</strong> curriculum has been changed from predominantly teaching<br />
<strong>of</strong> factual information towards teaching <strong>of</strong> students to build up <strong>the</strong> conceptual<br />
frameworks to which <strong>the</strong>y can add <strong>the</strong>ir personal knowledge by integrating<br />
information ga<strong>the</strong>red from different fields. Thus <strong>the</strong> students are<br />
guided to actively recognize <strong>the</strong> bridges between morphology, physiology,<br />
biochemistry, pharmacology and laboratory medicine to realize how <strong>the</strong><br />
changes at <strong>the</strong> molecular level may lead to pathological organ function,<br />
and to understand <strong>the</strong> principles <strong>of</strong> <strong>the</strong> pathogenic <strong>the</strong>rapy. On <strong>the</strong> o<strong>the</strong>r<br />
hand <strong>the</strong>y are provided with description <strong>of</strong> <strong>the</strong> signs, symptoms and syndromes<br />
so that <strong>the</strong>y understand <strong>the</strong> relations between <strong>the</strong> manifestations<br />
<strong>of</strong> diseases and <strong>the</strong> underlying mechanisms.<br />
3. The students are encouraged to take elective courses that help to learn<br />
pathophysiology. The staff members <strong>of</strong> <strong>the</strong> chair have prepared 3 new<br />
elective courses.<br />
4. The course <strong>of</strong> pathophysiology is condenced to be learned throughout one<br />
semester in parallel with learning pathological anatomy. This allows students<br />
to concentrate on <strong>the</strong> issues <strong>of</strong> pathology by comprehending <strong>the</strong><br />
knowledge from both disciplines – pathological anatomy and pathophysiology.<br />
3. Describe <strong>the</strong> strengths and weaknesses <strong>of</strong> <strong>the</strong> teaching.<br />
Strengths<br />
1. The staff members <strong>of</strong> <strong>the</strong> Chair <strong>of</strong> Pathophysiology have a long lasting experience<br />
in teaching <strong>of</strong> pathophysiology. Since most <strong>of</strong> <strong>the</strong>m have a scientific<br />
degree and all are involved in scientific research projects, <strong>the</strong>y are able<br />
to develop <strong>the</strong> research-based teaching.<br />
2. Since establishment <strong>of</strong> <strong>the</strong> new Biomedical Building (<strong>Biomeedikum</strong>) in<br />
1999 <strong>the</strong> teaching facilities have tremendously improved. It is now possible<br />
to explore <strong>the</strong> computer-aided lecturing and learning with a use <strong>of</strong> materials<br />
on compact discs and from internet, as well as to provide full service <strong>of</strong><br />
copying <strong>of</strong> <strong>the</strong> materials.<br />
3. The students are introduced to <strong>the</strong> basic techniques and methods <strong>of</strong> research<br />
in <strong>the</strong> Chair. Some experimental setups, e.g. oxygraphs and devices<br />
for muscle tension measurement are used for teaching purposes to<br />
introduce <strong>the</strong> basic mechanisms <strong>of</strong> cellular lesions such as Ca 2+ overload,<br />
mitochondrial dysfunction, etc. So <strong>the</strong> students become familiar with <strong>the</strong><br />
new technological achievements in producing new knowledge in <strong>the</strong> field <strong>of</strong><br />
pathophysiology, in order to understand <strong>the</strong> concepts <strong>of</strong> research- and evidence<br />
based medicine.<br />
4. Due to having now <strong>the</strong> modern laboratory equipment available (flame<br />
photometer, spectrophotometers, automatic hematological analyzer, etc)<br />
many parameters <strong>of</strong> <strong>the</strong> clinical specimen can be effectively analysed. For
PATHOPHYSIOLOGY<br />
students this makes study attractive and allows to substanciate <strong>the</strong> conclusions<br />
<strong>the</strong>y make from <strong>the</strong> combinations <strong>of</strong> <strong>the</strong> case studies.<br />
5. The study programs and <strong>the</strong> requirements are made clear for students in<br />
<strong>the</strong> beginning <strong>of</strong> <strong>the</strong> course. The hand-outs and copies <strong>of</strong> <strong>the</strong> slides demonstrated<br />
are given before <strong>the</strong> new topic <strong>of</strong> study. The relevant information<br />
is also available via internet in <strong>the</strong> home-page <strong>of</strong> <strong>the</strong> Chair <strong>of</strong> Pathophysiology.<br />
6. Despite limited funds, practically all important and modern textbooks written<br />
in Inglish and German languages are available for students in <strong>the</strong> field<br />
<strong>of</strong> pathophysiology ei<strong>the</strong>r in <strong>the</strong> Library <strong>of</strong> <strong>the</strong> Tartu University or in <strong>the</strong> Library<br />
<strong>of</strong> <strong>Biomeedikum</strong>.<br />
7. It has been concluded from <strong>the</strong> number <strong>of</strong> discussions that <strong>the</strong> topics <strong>of</strong><br />
pathophysiology should be teached during clinical part <strong>of</strong> medical education,<br />
i.e. more closely related with teaching <strong>of</strong> <strong>the</strong> different diseases. However,<br />
due to subjective and financial problems <strong>the</strong> relevant organizatory<br />
measures have remained still to be undertaken. To make progress in this<br />
issue, we have recently invited Dr. A. Beilmann, M.D. Ph.D. who works as<br />
a clinician in <strong>the</strong> field <strong>of</strong> children diseases, to become a staff member <strong>of</strong><br />
our Chair. We hope that in this way <strong>the</strong> clinical expertize <strong>of</strong> <strong>the</strong> Chair will<br />
be improved that, in turn, should positively influence <strong>the</strong> interaction between<br />
Clinical <strong>Department</strong>s and Chair <strong>of</strong> Pathophysiology.<br />
Weaknesses<br />
1. The staff members have still difficulties to effectively use all <strong>the</strong> opportunities<br />
that <strong>the</strong> new computer-assisted teaching technologies available in <strong>the</strong><br />
<strong>Biomeedikum</strong> can provide to. A great amount <strong>of</strong> handouts and o<strong>the</strong>r illustrative<br />
material need to be reshaped in a way that it could be used and distributed<br />
by <strong>the</strong> internet or o<strong>the</strong>r computerized networks.<br />
2. According to <strong>the</strong> regulations in <strong>the</strong> Faculty, <strong>the</strong> foreign students and native<br />
Estonian Russian speaking students have to know Estonian language in<br />
order to enter <strong>the</strong> 3 year program. However, many <strong>of</strong> <strong>the</strong> students still<br />
know Estonian insufficiently to understand <strong>the</strong> instructions in pathophysiology.<br />
3. The student-groups participating in <strong>the</strong> seminars/practicals in one room in<br />
<strong>the</strong> same time are too large that significantly limits <strong>the</strong> possibilities to<br />
stimulate <strong>the</strong> active work.<br />
4. Currently <strong>the</strong>re is no textbooks on pathophysiology written in Estonian language<br />
available.<br />
II. EVALUATION OF TEACHING<br />
4. How is <strong>the</strong> quality <strong>of</strong> <strong>the</strong> teaching in your department evaluated? How are<br />
<strong>the</strong> content and <strong>the</strong> modes <strong>of</strong> <strong>the</strong> teaching changed on <strong>the</strong> basis <strong>of</strong> evaluation?<br />
The staff members try to create an open atmosphere between <strong>the</strong>m and students.<br />
The students have been interviewed in order to receive <strong>the</strong> feedback.<br />
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SECTION I: SELF-EVALUATION<br />
182<br />
During <strong>the</strong> last few years <strong>the</strong> quality <strong>of</strong> lecturing as been two times evaluated<br />
by <strong>the</strong> students. The results have been distributed among <strong>the</strong> members <strong>of</strong> <strong>the</strong><br />
teaching staff to let <strong>the</strong>m know about <strong>the</strong> weak and strong aspects <strong>of</strong> <strong>the</strong>ir<br />
work.<br />
The most systematic evaluation that was co-ordinated by <strong>the</strong> University<br />
authorities was accomplished in November/December 2000. The teacher’s<br />
work was evaluated during <strong>the</strong> last lecture <strong>of</strong> <strong>the</strong> course. The results will be<br />
made public after <strong>the</strong> students have passed <strong>the</strong> exam.<br />
III. PEDAGOGIC TRAINING OF STAFF<br />
5. How many <strong>of</strong> <strong>the</strong> teachers have received pedagogic training?<br />
Two teachers have attended <strong>the</strong> formal courses <strong>of</strong> pedagogic training with duration<br />
<strong>of</strong> two weeks. The majority <strong>of</strong> staff members participated in international<br />
Workshop on medical curriculae (January 19-20,1996 University <strong>of</strong> Tartu)<br />
were problem-based learning with study demonstration, development <strong>of</strong> preclinical<br />
and clinical curriculum, international development <strong>of</strong> medical curriculum<br />
and o<strong>the</strong>r problems were scrutinized. The teachers have also attended <strong>the</strong><br />
courses in which <strong>the</strong> possibilities and technology <strong>of</strong> Internet videoconference<br />
have been demonstrated.<br />
6. Is <strong>the</strong>re a need for fur<strong>the</strong>r pedagogic training?<br />
There is a need for fur<strong>the</strong>r training in using <strong>the</strong> computer technology in <strong>the</strong><br />
teaching process.<br />
IV. TEACHING RESOURCES<br />
7. Is <strong>the</strong>re a need rearrangement <strong>of</strong> <strong>the</strong> teaching resources in your department?<br />
If so, how should this be done?<br />
At present <strong>the</strong> Chair <strong>of</strong> Pathophysiology comprises 5 members <strong>of</strong> <strong>the</strong> teaching<br />
staff. Since all teachers are graduated from <strong>the</strong> Faculty <strong>of</strong> Medicine, <strong>the</strong>y have<br />
basic education in pathophysiology, as well as <strong>the</strong>y are capable to extend <strong>the</strong>ir<br />
experience and skills and understand <strong>the</strong> position and role <strong>of</strong> pathophysiology<br />
in <strong>the</strong> context <strong>of</strong> <strong>the</strong> medical curriculum. In addition, <strong>the</strong> researchers and Ph.D.<br />
students have been involved in teaching in part-time manner.<br />
During recent years, <strong>the</strong> workload <strong>of</strong> <strong>the</strong> teaching staff has been increasing<br />
above <strong>the</strong> normative load. Therefore, it is reasonable to complete <strong>the</strong> teaching<br />
staff by one teacher.<br />
V. COORDINATION OF THE TEACHING<br />
8. How is <strong>the</strong> teaching co-ordinated with o<strong>the</strong>r departments? Indicate <strong>the</strong> departments<br />
that are closest to your department.<br />
1. Teaching <strong>of</strong> pathophysiology is co-ordinated at different levels: internationally<br />
and institutionally both at <strong>the</strong> university and faculty levels. Internationally<br />
<strong>the</strong> recommendations <strong>of</strong> different organisations have been followed<br />
(e.g. International Society for Pathophysiology Commission on Teaching,
PATHOPHYSIOLOGY<br />
Advisory Committee on Medical Training <strong>of</strong> <strong>the</strong> Commission <strong>of</strong> <strong>the</strong> European<br />
Communities) in order to implement <strong>the</strong> modern concepts <strong>of</strong> teaching.<br />
2. At <strong>the</strong> University level <strong>the</strong> pathophysiology program is registered and described<br />
in <strong>the</strong> Catalogue <strong>of</strong> <strong>the</strong> Lectures and Practical works. So <strong>the</strong><br />
courses in pathophysiology are available for and can be taken by any student<br />
in <strong>the</strong> University. For almost ten years <strong>the</strong> Chair <strong>of</strong> Pathophysiology<br />
has been involved in cooperation with <strong>the</strong> Faculty <strong>of</strong> Exercise and Sport<br />
Sciences by teaching <strong>the</strong> Bachelor’s level course ARMP.03.005 “Pathophysiology”<br />
for physio<strong>the</strong>rapists. The co-work is coordinated not only in<br />
terms <strong>of</strong> <strong>the</strong> content <strong>of</strong> <strong>the</strong> program but also financially, as <strong>the</strong> teaching<br />
services given by <strong>the</strong> Chair <strong>of</strong> Pathophysiology are payed by <strong>the</strong> Faculty <strong>of</strong><br />
Exercise and Sport Sciences.<br />
3. At <strong>the</strong> Faculty level <strong>the</strong> relationships between pathophysiology and laboratory<br />
medicine have been extensively analysed during <strong>the</strong> period when<br />
laboratory medicine was introduced as a new discipline in <strong>the</strong> medical curriculum.<br />
This work was coordinated by <strong>the</strong> TEMPUS Structural Joint European<br />
Project 7784/94 Development <strong>of</strong> Academic Laboratory Medicine, with<br />
participation <strong>of</strong> University <strong>of</strong> Glasgow, University <strong>of</strong> Odense, and University<br />
<strong>of</strong> Turku. The aim <strong>of</strong> coordination was to maximally avoid overlapping <strong>of</strong><br />
<strong>the</strong> content <strong>of</strong> programs and to achieve <strong>the</strong> best synergistic effect <strong>of</strong><br />
teaching <strong>of</strong> different subjects.<br />
4. Coordination <strong>of</strong> teaching between pathophysiology and pathological anatomy<br />
goes back to early eighties. The new curriculum presumes especially<br />
tight coordination because <strong>the</strong> subjects are now teached within one block<br />
– pathology (11 credit points).<br />
5. During recent years a new Chair <strong>of</strong> Immunology has been established in<br />
<strong>the</strong> <strong>Department</strong> <strong>of</strong> General and Molecular Pathology. Due to such a development<br />
<strong>the</strong> program <strong>of</strong> pathophysiology has been revised in that <strong>the</strong> specific<br />
issues <strong>of</strong> immunopathology have been removed in order to be teached<br />
by <strong>the</strong> Chair <strong>of</strong> Immunology.<br />
6. Since <strong>the</strong> present academic year <strong>the</strong> detailed study program <strong>of</strong> pathophysiology<br />
can be found at <strong>the</strong> homepage <strong>of</strong> <strong>the</strong> Chair. This has allowed<br />
<strong>the</strong> students to be better prepared for <strong>the</strong> lectures, seminars and practical<br />
works, as well as to inform o<strong>the</strong>r <strong>Department</strong>s.<br />
7. The integration <strong>of</strong> pathophysiology with o<strong>the</strong>r disciplines has been a regular<br />
subject <strong>of</strong> discussion in frames <strong>of</strong> <strong>the</strong> work <strong>of</strong> <strong>the</strong> Committee <strong>of</strong> Curriculum<br />
Development which during last 7 years has been headed by <strong>the</strong><br />
Pr<strong>of</strong>essor <strong>of</strong> Pathophysiology, Enn Seppet.<br />
VI. FUTURE PLANS<br />
9. Future plans to improve <strong>the</strong> teaching given by <strong>the</strong> department.<br />
1. During coming years <strong>the</strong> content and quality <strong>of</strong> teaching can be improved<br />
through realization <strong>of</strong> <strong>the</strong> following measures:<br />
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SECTION I: SELF-EVALUATION<br />
184<br />
2. By <strong>the</strong> 2001/2002 Academic year <strong>the</strong> Textbook <strong>of</strong> Pathophysiology in Estonian<br />
language will be published; <strong>the</strong> relevant work has been started and<br />
occurs as it is planned.<br />
3. Increasing <strong>of</strong> <strong>the</strong> number <strong>of</strong> students involved in <strong>the</strong> research projects in<br />
order to enhance <strong>the</strong> role <strong>of</strong> research-based learning.<br />
4. Application <strong>of</strong> <strong>the</strong> available techniques and apparatus for computer-based<br />
teaching/learning including <strong>the</strong> multimedia computer systems in lecture hall<br />
(Ravila 19-1006) and seminar/laboratory room (Ravila 19-1016) <strong>of</strong> <strong>the</strong><br />
<strong>Biomeedikum</strong>. The interactive computer programs will be used in seminars<br />
and for self-learning on <strong>the</strong> basis <strong>of</strong> <strong>the</strong> computer class available for students.
PATHOPHYSIOLOGY<br />
Pathophysioloy: resource evaluation<br />
1. Study materials<br />
- How many study books are published in your institution during last five years? 0<br />
- Do you have separate room as library in your place? Yes No<br />
- Could students borrow study books from your institution? Yes No<br />
- Do you have on-line published study materials for students? Yes No<br />
- WWW address: http://heart.med.ut.ee<br />
- Does University library has enough modern books in your speciality?<br />
Completely enough Enough Scarcely Absolutely scarcely No<br />
2. Amount and size <strong>of</strong> study rooms<br />
- Rooms used by Your institution only: 1 rooms with area <strong>of</strong> 61 m 2<br />
- Rooms shared with ano<strong>the</strong>r institution: 1 rooms with area <strong>of</strong> 40 m 2<br />
- Do You have enough space for study process by Your opinion?<br />
Completely enough Enough Scarce Absolutely scarcely<br />
- How <strong>the</strong> scarce <strong>of</strong> space should be handled or changed?<br />
New building Change to smaller student groups Better logistics<br />
O<strong>the</strong>r way (describe shortly)<br />
3. Current situation <strong>of</strong> study rooms<br />
- There has been repairments in last years (except Biomedicum)<br />
- How are <strong>the</strong> study rooms lightened?<br />
Very good Good Some darkness Absolutely dark for study<br />
- Evaluation <strong>of</strong> general conditions: Very good Good Satisfactory Bad<br />
4. Your institution has<br />
a) 1 (how many?) auditorium(s) for workshops/seminars with 24 places, equipped with<br />
Blackboard<br />
White board & markers<br />
Screen<br />
Overhead projector<br />
Data projector<br />
Slide projector<br />
b) 1 (how many?) laboratories for practicals with 24 places, equipped with<br />
Blackboard<br />
White board and markers<br />
Screen<br />
Overhead projector<br />
Data projector<br />
Slide projection kit<br />
TV/Video projection set<br />
Computer<br />
Internet connection<br />
TV/Video projection kit<br />
Computer<br />
Internet connection<br />
5. Working rooms for teaching staff and postgraduate students:<br />
- Number <strong>of</strong> teaching staff 5<br />
- Number <strong>of</strong> rooms for staff 4<br />
- Number <strong>of</strong> individual working places 5, among <strong>the</strong>m with computers 4<br />
- Number <strong>of</strong> postgraduate students is 3<br />
- How many individual working places <strong>the</strong>y have? 3<br />
- How many computers <strong>the</strong>y have? 2<br />
6. O<strong>the</strong>r comments on resource topic (max 250 letters): Auditorium nr 4003 for<br />
workshops and seminars with 24 places is shared with <strong>Department</strong> <strong>of</strong> Microbiology.<br />
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SECTION I: APPENDIXES<br />
APPENDIX I-I<br />
Visits <strong>of</strong> <strong>the</strong> Chair members to o<strong>the</strong>r institutions abroad during 1996-2000<br />
Year Researcher/Lectures Institution Country Purpose Duration<br />
1996 Margareeta Mudist, techician, student Karolinska Institutet Sweden Research 4 weeks<br />
1997 Evelin Seppet, Ph.D. student Karolinska Institutet Sweden Research 4 weeks<br />
1998 Urmo Braun, Ph.D. student Karolinska Institutet Sweden Research 8 weeks<br />
1998 Enn Seppet, pr<strong>of</strong>essor University <strong>of</strong> Halle Germany Research 8 weeks<br />
2000 Lumme Kadaja, reseacher University <strong>of</strong> Uppsala Sweden Research 2 weeks<br />
APPENDIX I-II<br />
Postgraduate students at <strong>the</strong> <strong>Department</strong> having studied abroad during 1996-2000<br />
Year <strong>Name</strong> Institution Contry Duration<br />
1996 Ave Minajeva Paris-Sud University France 6 months<br />
1997 Ave Minajeva Paris-Sud University France 3 months<br />
1997 Allen Kaasik Paris-Sud University France 3 months<br />
1997 Evelin Seppet Karolinska Institutet Sweden 4 weeks<br />
1998 Urmo Braun Karolinska Institutet Sweden 8 weeks<br />
APPENDIX I-III<br />
Co-operation with institutions from o<strong>the</strong>r countries and participation in international<br />
research projects during 1996-2000<br />
Contact person Institution Country Aim<br />
Pr<strong>of</strong>. Kent Sahlin Karolinska Institutet Sweden Research<br />
Pr<strong>of</strong>. Bertil Fredholm Karolinska Institutet Sweden Research<br />
Pr<strong>of</strong>. Jorma Ohisalo University <strong>of</strong> Helsinki Finland Research, teaching<br />
Pr<strong>of</strong>. Valdur Saks University <strong>of</strong> Grenoble France Research<br />
Dr. Renée Ventura-Clapier Paris-Sud University France Research<br />
Dr. Roland Vetter Max Delbrück Center for Molecular Medicine, Germany<br />
Berlin<br />
Research<br />
Dr. Frank N. Gellerich University <strong>of</strong> Halle Germany Research<br />
APPENDIX I-IV<br />
Visiting lecturers at <strong>the</strong> <strong>Department</strong> during 1996-2000<br />
Visitor Institution Country Purpose <strong>of</strong> <strong>the</strong> Visit<br />
Pr<strong>of</strong>. Stefan Zierz University <strong>of</strong> Halle/s. Germany Research<br />
Pr<strong>of</strong>. Kent Sahlin Karolinska Institutet Sweden Research<br />
Pr<strong>of</strong>. Valdur Saks University <strong>of</strong> Grenoble France Research<br />
APPENDIX I-V<br />
Scientific journals available at <strong>the</strong> Chair<br />
No <strong>Name</strong> <strong>of</strong> Journal Version<br />
1. Biophysical Journal paper<br />
186
APPENDIX I-V<br />
Publications <strong>of</strong> <strong>the</strong> <strong>Department</strong> members during 1996-2000<br />
MONOGRAPHS<br />
PATHOPHYSIOLOGY<br />
1. Kaasik A. Thyroid hormone control over [beeta]-adrenergic signalling system in rat atria. Tartu,<br />
1998, Dissertation.<br />
2. Minajeva A. Sarcoplasmic reticulum function: comparison <strong>of</strong> atrial and ventricular myocardium.<br />
Tartu, 1998, Dissertation.<br />
PAPERS IN INTERNATIONAL JOURNALS<br />
1. Andrejeva J., Merits A., Rabenstein F., Puurand Ü., Järvekülg L. Comparison <strong>of</strong> <strong>the</strong> nucleotide sequences<br />
<strong>of</strong> <strong>the</strong> 3'-terminal regions <strong>of</strong> one aphid and two non-aphid transmissible isolates <strong>of</strong> potato A<br />
potyvirus. – Archives <strong>of</strong> Virology, 1996, 141, 7, 1207-1219.<br />
2. Kaasik A., Ohisalo J. Membrane-bound phosphodiesterases in rat myocardium. – J. Pharm. Pharmacol.,<br />
1996, 48, 962-964<br />
3. Kuznetsov A.V., Tiivel T., Sikk P., Käämbre T., Kay L., Daneshrad Z., Rossi A., Kadaja L., Peet N.,<br />
Seppet E., Saks VA. Striking differences between <strong>the</strong> kinetics <strong>of</strong> regulation <strong>of</strong> respiration by ADP in<br />
slow-twitch and fast-twitch muscles in vivo. – Eur J Biochem., 1996, 241, 3, 909-915.<br />
4. Minajeva A., Ventura-Clapier R., Veksler V. Ca2+ uptake by cardiac sarcoplasmic reticulum ATPase<br />
in situ strongly depends on bound creatine kinase. – Pflügers Arch. – Eur. J. Physiol., 1996,<br />
432, 904-912<br />
5. Puurand Ü., Valkonen J.P., Mäkinen K., Rabenstein F., Saarma M. Infectious in vitro transcripts<br />
from cloned cDNA <strong>of</strong> <strong>the</strong> potato A potyvirus. – Virus Research, 1996, 40, 2, 135-40.<br />
6. Kaasik A., Minajeva A., Paju K., Eimre M., Seppet EK. Thyroid hormones differentially affect sarcoplasmic<br />
reticulum function in rat atria and ventricles. – Mol Cell Biochem., 1997, 176, 1-2, 119-126.<br />
7. Kaasik A., Paju K., Vetter R., Seppet EK. Thyroid hormones increase <strong>the</strong> contractility but suppress<br />
<strong>the</strong> effects <strong>of</strong> beta-adrenergic agonist by decreasing phospholamban expression in rat atria. – Cardiovasc<br />
Res. 1997, 35, 1, 106-112.<br />
8. Looga R. Reflex Cardiovascular responses to lung inflation – a review. Respiration Physiology,<br />
1997, 109, 2, 95-106<br />
9. Minajeva A., Kaasik A., Paju K., Seppet E., Lompre AM., Veksler V., Ventura-Clapier R. Sarcoplasmic<br />
reticulum function in determining atrioventricular contractile differences in rat heart. – Am J<br />
Physiol. 1997, 273, H2498-H2507.<br />
10. Seppet EK., Kaasik A., Minajeva A., Paju K., Ohisalo JJ., Vetter R., Braun U. Mechanisms <strong>of</strong> thyroid<br />
hormone control over sensitivity and maximal contractile responsiveness to beta-adrenergic<br />
agonists in atria. – Mol Cell Biochem., 1998, 184, 419-426.<br />
11. Schelle T., Seppet E., Wussling M.H.P. Comparison <strong>of</strong> hyperthyroid and euthyroid rat cardiac<br />
myocytes with respect to sarcomere dynamics and calcium transients. B stuty by laser diffractometry<br />
and confocal laser microscopy. – Scripta Medica (Brno), 1998, 70, 8, 395-408.<br />
12. Andrejeva L., Puurand Ü., Merits A., Rabenstein F., Järvekülg L., Valkonen JP. Potyvirus helper<br />
component-proteinase and coat protein (CP) have coordinated functions in virus-host interactions<br />
and <strong>the</strong> same CP motif affects virus transmission and accumulation. – Journal <strong>of</strong> General Virology,<br />
1999, 80, 5, 1133-1139.<br />
13. Beilmann A., Napa A., Hämarik M., Sööt A., Talvik I., Talvik T. Incidence <strong>of</strong> childhood epilepsy in<br />
Estonia. – Brain & Development, 1999, 21, 3, 166-174.<br />
14. Beilmann A., Napa A., Sööt A., Talvik I., Talvik T. Prevalence <strong>of</strong> childhood epilepsy in Estonia. –<br />
Epilepsia. 1999, 40, 7, 1011-1019.<br />
15. Beilmann A., Talvik T. Is <strong>the</strong> International League against Epilepsy classification <strong>of</strong> epileptic syndromes<br />
applicable to children in Estonia? – Europ. J. Paediatr. Neurol., 1999, 3, 6, 265-272.<br />
16. Beilmann A., Talvik T. Epileptic syndromes in Estonia, International Proceedings <strong>of</strong> 3 rd EPNS Congress,<br />
Bologna Italy, Monduzzi Editore, 1999, 97-104<br />
17. Gellerich FN., Trumbeckaite S., Opalka JR., Seppet E., Rasmussen HN., Neuh<strong>of</strong>f C., Zierz S.<br />
Function <strong>of</strong> <strong>the</strong> mitochondrial outer membrane as a diffusion barrier in health and diseases. – Biochem<br />
Soc Trans. 2000, 28, 2, 164-169.<br />
18. Seppet E.K., Käämbre T., Sikk P., Tiivel T., Vija H., Tonkonogi M., Sahlin K., Kay L., Appaix F.,<br />
Braun U., Eimre M., Saks V.A. Functional complexes <strong>of</strong> mitochondria with Ca, MgATPases <strong>of</strong> my<strong>of</strong>ibrils<br />
and sarcoplasmic reticulum in muscle cells. – Biochim. Biophys. Acta, 2000, 45020, 1-17.<br />
187
SECTION I: APPENDIXES<br />
19. Tiivel T., Kadaya L., Kuznetsov A., Kaambre T., Peet N., Sikk P., Braun U., Ventura-Clapier R.,<br />
Saks V., Seppet EK. Developmental changes in regulation <strong>of</strong> mitochondrial respiration by ADP and<br />
creatine in rat heart in vivo. – Mol Cell Biochem. 2000, 208, 119-128.<br />
PAPERS IN ESTONIAN JOURNALS<br />
1. Seppet E., Minajeva A., Seppet E. Essentsiaalse hüpertensiooni patogenees. – Eesti Arst, 1996, 1,<br />
55-59.<br />
2. Beilmann A. Uued epilepsiaravimid. – Eesti Arst, 1997, 1 38-52.<br />
3. Orlova E., Viru A. Endogeensed opioidsed peptiidid, nende osa stressi ja adaptatsiooni puhul. –<br />
Eesti Arst 1998, 3, 251-258.<br />
4. Truusalu K., Vainumäe I., Puurand Ü., Talvik T., Mikelsaar M. Korduvate uroinfektsioonidega laste<br />
E.coli tüvede tüpiseerimine. – Eesti Arst, 2000, 9, 570.<br />
SUBMITTED PAPERS<br />
1. Braun U., Paju K., Eimre M., Orlova E., Seppet E., Kadaja L., Trumbekaite S., Gellerich F.N., Zierz<br />
S., Seppet E.K. Lack <strong>of</strong> dystrophin is associated with altered integration <strong>of</strong> mitochondria and<br />
ATPases in slow-twitch muscle cells <strong>of</strong> MDX mice. – Biochim. Biophys. Acta.<br />
2. Looga R. The bradycardic response to <strong>the</strong> valsalva manoeuvre in normal man. – Respiration<br />
Physiology.<br />
3. Menin L., Panchichkina M., Keriel C., Olivares J., Braun U., Seppet E.K., Saks V.A.<br />
Macrocompartmentation <strong>of</strong> total creatine in cardiomyocytes revisited. – Mol. Cell. Biochem.<br />
4. Saks V.A., Käämbre T., Sikk P., Eimre M., Orlova E., Paju K., Piirsoo A., Appaix F., Kay L., Regitz-<br />
Zagrosek V., Fleck E., Seppet E. Intracellular energetic units in muscle cells. – Biochem. J.<br />
188
APPENDIX I-VII<br />
Academic and administrative personnel: Chair <strong>of</strong> Pathophysiology<br />
PATHOPHYSIOLOGY<br />
<strong>Name</strong> Title Load Area Gender Birth year Scientific degree Year <strong>of</strong> commencement Labour time (y)<br />
1. Enn Seppet Pr<strong>of</strong>essor 1,00 Pathophysiology Male 1950 Ph.D 1991 26<br />
2. Kalju Paju Docent 1,00 Pathophysiology Male 1952 Cand.Sci 1986 21<br />
3. Ehte Orlova Lecturer 1,00 Pathophysiology Female 1953 Cand.Sci 1992 12<br />
4. Anneli Beilmann Assistant 0,50 Pathophysiology/neurology Female 1956 Dr.Med 1999 2<br />
5. Urmo Braun Assistant 0,50 Pathophysiology Male 1967 1<br />
6. Lumme Kadaja Researcher 1,00 Pathophysiology Female 1952 M.Sc 1993 20<br />
7. Ülo Puurand Researcher 1,00 Molecular biology Male 1963 Ph.D 1997 1<br />
8. Merike Kruus Sr. Technical staff 0,50 Female 1962 16<br />
9. Ellen Gvozdkova Technical staff 0,50 Female 1946 28<br />
10. Margareeta Mudist Technical staff 1,00 Female 1970 3<br />
1 Cand.Sci is degree <strong>of</strong> <strong>the</strong> Former Soviet Union which corresponds to a Ph.D<br />
189
APPENDIX I-VIII<br />
Curriculum Vitae <strong>of</strong> <strong>the</strong> staff<br />
PATHOPHYSIOLOGY<br />
SEPPET. ENN K. 2. Date <strong>of</strong> birth: 26.02.1950 3. Gender: Male 4. Citizenship: Estonia 5. Address:<br />
12-33 Kalda tee, 50703 Tartu, Estonia 6. Educational history: 1968-1974: Medical Faculty, University<br />
<strong>of</strong> Tartu, Tartu, Estonia, M.D., University <strong>of</strong> Tartu, 1974. 1977-1980: USSR National Center for<br />
Cardiology, Moscow, Soviet Union, Post-graduate Research in Biochemistry. 7. Academic degrees<br />
(with year and university): 1980: Candidate <strong>of</strong> Sciences in Biochemistry, USSR National Center for<br />
Cardiology, Moscow, USSR. 1991: Doctor <strong>of</strong> Philosophy (Physiology), University <strong>of</strong> Tartu, Estonia 8.<br />
Employment and pr<strong>of</strong>essional experience: 1974-1981: Junior and Senior Research Fellow, Laboratory<br />
<strong>of</strong> Muscle Research, University <strong>of</strong> Tartu, Estonia. 1981-1992: Head, Laboratory <strong>of</strong> Hormonal<br />
Regulation, Faculty <strong>of</strong> Medicine, University <strong>of</strong> Tartu, Estonia. 1992-present: Pr<strong>of</strong>essor and Chairman,<br />
Chair <strong>of</strong> Pathophysiology, Institute <strong>of</strong> General and Molecular Pathology, Faculty <strong>of</strong> Medicine, University<br />
<strong>of</strong> Tartu, Estonia. 9. Administrative experience: 1993-1999, Head, Curriculum Development<br />
Committee, Faculty <strong>of</strong> Medicine, University <strong>of</strong> Tartu, Estonia. 1994-2000, Vice-Dean for research and<br />
postgraduate degree education, Faculty <strong>of</strong> Medicine, University <strong>of</strong> Tartu, Estonia. 10. Honours and<br />
awards:- Membership in academic and scientific societies: International Society for Heart Research,<br />
Federation <strong>of</strong> European Biochemical Societies Finnish Physiological Society, Baltic Laboratory<br />
Animal Societies Association, Estonian Physiological Society. 12. Current research program 1.The intracellular<br />
systems <strong>of</strong> energy transfer in normal and and grants:pathological conditions. Grant<br />
0180419s98 from <strong>the</strong> Ministry <strong>of</strong> Education, Estonia. Grantholder: Enn Seppet. 2. The energy transfer<br />
networks in muscle cells. Grant 3637 from <strong>the</strong> Estonian Science Foundation, Estonia. Grantholder:<br />
Enn Seppet. Supervision <strong>of</strong> dissertations: 3 Master <strong>of</strong> Sciences (A.Kaasik, 1993.a., L. Kadaja,<br />
1993.a., T. Käämbre, 1999.a.) 2 Dr Med Sci (A. Kaasik, 1998.a., A. Minajeva, 1998.a.). 14. Publications:<br />
56 full length papers<br />
PAJU, KALJU Date <strong>of</strong> birth: 21.03.1952 Gender: male Citizenship: Estonian Address: 1-6 Nõva,<br />
50104 Tartu, Estonia 6. Educational history: 1970-1976: Medical Faculty, University <strong>of</strong> Tartu, Estonia<br />
M.D., University <strong>of</strong> Tartu, 1976. 1976-1979: Postgraduate student, <strong>Department</strong> <strong>of</strong> Pathophysiology,<br />
University <strong>of</strong> Tartu, Estonia Academic degrees (with year and University): 1985: Candidate <strong>of</strong> Sciences<br />
in Pathophysiology (Cand. Sci), Institute <strong>of</strong> Continuation <strong>of</strong> Medicine, Leningrad, USSR Employment<br />
and pr<strong>of</strong>essional experience: 1979-1986: Assistant, <strong>Department</strong> <strong>of</strong> Pathophysiology, University<br />
<strong>of</strong> Tartu, Estonia 1986-1992: Docent, <strong>Department</strong> <strong>of</strong> Pathophysiology, University <strong>of</strong> Tartu, Estonia<br />
1992-present: Docent, Chair <strong>of</strong> Pathophysiology, <strong>Department</strong> <strong>of</strong> General and Molecular Pathology,<br />
University <strong>of</strong> Tartu, Estonia Administrative experience: 1986 –1992: Head <strong>of</strong> <strong>Department</strong> <strong>of</strong><br />
Pathophysiology, University <strong>of</strong> Tartu Honours and awards: - Membership in academic and scientific<br />
societies: 1977 – 1991: Estonian Society <strong>of</strong> Pathophysiology Current research program and<br />
grants:1.The intracellular systems <strong>of</strong> energy transfer in normal and pathological conditions. Grant<br />
0180419s98 from <strong>the</strong> Ministry <strong>of</strong> Education, Estonia 2. The energy transfer networks in muscle cells.<br />
Grant 3637 from <strong>the</strong> Estonian Science Foundation, Estonia Supervision <strong>of</strong> dissertations: - Publications:<br />
7 full length papers<br />
ORLOVA, EHTE Date <strong>of</strong> birth: 18.12.1953 Gender:Female Citizenship: Estonian Address:12-23 Pepleri,<br />
51003 Tartu, Estonia 6. Educational history: 1972-1978: Medical faculty, University <strong>of</strong> Tartu,<br />
Estonia M.D., University <strong>of</strong> Tartu, Estonia, 1978 1978-1979: Internship in Tartu Sports Dispanser, Estonia<br />
1982-1988: postgraduate student, <strong>Department</strong>s <strong>of</strong> Sports Physiology, University <strong>of</strong> Tartu, Estonia<br />
and Institute <strong>of</strong> General Pathology and Pathophysiology, Moscow, USSR 7. Academic degrees<br />
:1992: Candidate <strong>of</strong> sciences in pathophysiology (Cand.Sci), Institute <strong>of</strong> General Pathology and<br />
Pathophysiology, Moscow, USSR Employment and pr<strong>of</strong>essional experience: 1978-1982: Sports<br />
physician, <strong>the</strong> centre <strong>of</strong> training “Otepää”, Soviet Union Sports Committee and <strong>the</strong> Sports School <strong>of</strong><br />
Tallinn, Estonia 1988-1990: Assistant, <strong>Department</strong> <strong>of</strong> Pathophysiology, University <strong>of</strong> Tartu, Estonia<br />
1988-1992: Senior assistant, <strong>Department</strong> <strong>of</strong> Pathophysiology, University <strong>of</strong> Tartu, Estonia 1992present:<br />
Senior assistant, Chair <strong>of</strong> Pathophysiology, <strong>Department</strong> <strong>of</strong> General and Molecular Pathology,<br />
University <strong>of</strong> Tartu, Estonia Administrative experience: 1992: participation in organisation <strong>of</strong> conference<br />
Research in Medicine (Medical faculty, University <strong>of</strong> Tartu) Honours and awards: - Membership<br />
in academic and scientific societies: - Current research program and grants:1.The intracellular<br />
systems <strong>of</strong> energy transfer in normal and pathological conditions. Grant 0180419s98 from <strong>the</strong> Ministry<br />
<strong>of</strong> Education, Estonia 2. The energy transfer networks in muscle cells. Grant 3637 from <strong>the</strong> Estonian<br />
Science Foundation, Estonia Supervision <strong>of</strong> dissertations: - Publications: 11 full length papers (5<br />
current content)<br />
191
SECTION I: APPENDIXES<br />
BEILMANN, ANNELI 2. Date <strong>of</strong> birth: 28.06.1956 3. Gender: Female 4. Citizenship: Estonian 5. Address:<br />
58-2 Suur-Kaar, 50405 Tartu, Estonia 6. Educational history: 1974-1981: Medical Faculty,<br />
University <strong>of</strong> Tartu, Estonia M.D., University <strong>of</strong> Tartu, Estonia, 1981. 1994-1999: PhD student, <strong>Department</strong><br />
<strong>of</strong> Pediatrics, University <strong>of</strong> Tartu, Estonia 7. Academic degrees: 1999: doctor <strong>of</strong> medical<br />
sciences (Dr.Med), University <strong>of</strong> Tartu, Estonia 8. Employment and pr<strong>of</strong>essional experience:1983-<br />
1989: pediatrician, Children’s Hospital <strong>of</strong> Tartu, Estonia 1987-present: neurophysiologist, Children’s<br />
Hospital <strong>of</strong> Tartu, Estonia 1990-present: neurologist, Clinic <strong>of</strong> Pediatrics, Clinic <strong>of</strong> Neurology and Neurosurgery,<br />
University <strong>of</strong> Tartu, Estonia 1999-present: assistant, Chair <strong>of</strong> Pathophysiology, <strong>Department</strong><br />
<strong>of</strong> General and Molecular Pathology, University <strong>of</strong> Tartu, Estonia 9. Administrative experience: - 10.<br />
Honours and awards: 1999: scientific award <strong>of</strong> Estonian League Against Epilepsy <strong>of</strong> Estonia Membership<br />
in academic and scientific societies: Vice-president <strong>of</strong> Estonian League <strong>of</strong> Neurophysiologists<br />
Estonian Association <strong>of</strong> Pediatricians Baltic Association <strong>of</strong> Child Neurologists Estonian Association <strong>of</strong><br />
Neurologists Estonian League Against Epilepsy Current research program and grants: Identification<br />
<strong>of</strong> epileptic syndromes in children, establishing <strong>of</strong> psychopathology <strong>of</strong> frontal lobe epilepsy. Grant<br />
3121 from <strong>the</strong> Estonian Science Foundation, Estonia. Supervision <strong>of</strong> dissertations: - 14. Publications:<br />
6 full length papers /international medical journals/, 5 publications in medical journals <strong>of</strong> Estonia.<br />
BRAUN, URMO 2. Date <strong>of</strong> birth:30.08.1967 3. Gender:Male 4. Citizenship:Estonian 5. Address:63-41<br />
Mõisavahe, Tartu, Estonia 6. Educational history:1985-1993: Medical Faculty, University <strong>of</strong> Tartu,<br />
Estonia M.D., University <strong>of</strong> Tartu, 1993. 1993-1994: internship, Out-patient <strong>Department</strong> <strong>of</strong> Tartu, Estonia<br />
1997-present: Ph.D. student, Chair <strong>of</strong> Pathophysiology, <strong>Department</strong> <strong>of</strong> General and Molecular<br />
Pathology, University <strong>of</strong> Tartu, Estonia Academic degrees (with year and university):- Employment<br />
and pr<strong>of</strong>essional experience:1993-1995: IT specialist, Chion IC, Estonia 1995-1997: IT specialist,<br />
EW-Travel IC, Estonia 2000-present: Assistant (0.5), Chair <strong>of</strong> Pathophysiology, <strong>Department</strong> <strong>of</strong> General<br />
and Molecular Pathology, University <strong>of</strong> Tartu, Estonia Administrative experience: - Honours and<br />
awards: - Membership in academic and scientific societies:- Current research program and<br />
grants:1.The intracellular systems <strong>of</strong> energy transfer in normal and pathological conditions. Grant<br />
0180419s98 from <strong>the</strong> Ministry <strong>of</strong> Education, Estonia 2. The energy transfer networks in muscle cells.<br />
Grant 3637 from <strong>the</strong> Estonian Science Foundation, Estonia Supervision <strong>of</strong> dissertations: - 14. Publications:3<br />
full length papers KADAJA, LUMME 2. Date <strong>of</strong> birth:17.08.1952 3. Gender:Female 4. Citizenship:<br />
Estonian 5. Address: 17-12 Mõisavahe, 50707 Tartu, Estonia 6. Educational history:<br />
1971-1978: Dept. Chemistry, University <strong>of</strong> Tartu, Estonia 1992-1993: Master’s Course in biomedicine,<br />
<strong>Department</strong> General and Molecular Pathology, University <strong>of</strong> Tartu, Estonia Academic degree (with<br />
year and university): M.Sc., 1993, University <strong>of</strong> Tartu, Estonia Employment and pr<strong>of</strong>essional experience:<br />
1980-1983: senior laboratory assistant, <strong>Department</strong> <strong>of</strong> General and Molecular Pathology, University<br />
<strong>of</strong> Tartu, Estonia 1983-1984: engineer, <strong>Department</strong> <strong>of</strong> General anf Molecular Pathology 1985-<br />
1986: senior engineer, <strong>Department</strong> <strong>of</strong> General and Molecular Pathology 1987-1990: junior researcher,<br />
<strong>Department</strong> <strong>of</strong> General and Molecular Pathology 1991-2001: researcher, <strong>Department</strong> <strong>of</strong> General and<br />
Molecular Pathology 9. Administrative experience: The member <strong>of</strong> Committee <strong>of</strong> Ethics <strong>of</strong> Tartu<br />
University Honours and awards: - Membership in academic and scientific societies: ScandLASA<br />
(Scandinavian Laboratory Animal Association) EstLASA (Estonian Laboratory animal Association)<br />
Current research program and grants: 1.The intracellular systems <strong>of</strong> energy transfer in normal an<br />
pathological conditions. Grant 0180419s98 from <strong>the</strong> Ministry <strong>of</strong> Education, Estonia. 2. The energy<br />
trasfer networks in muscle cells. Grant 3637 from <strong>the</strong> Estonian Science Foundation, Estonia. 3. Cytosceleton-mitochondrial<br />
interactions; A new method in genome analysis, Grant 716 Kt from Estonian<br />
Technology Agency, Estonia Supervision <strong>of</strong> dissertations: - Publications: 7 full length papers<br />
PUURAND, ÜLO Date <strong>of</strong> birth: 20.12.1963 Gender: Male Citizenship: Estonian Address: 98-58 Pikk,<br />
50606Tartu, Estonia Educational history: biologist, graduated in University <strong>of</strong> Tartu, 1986 Academic<br />
degrees (with year and university): Ph.D., 1997, University <strong>of</strong> Tartu, Estonia Employment and pr<strong>of</strong>essional<br />
experience:1986-1990: researcher, Institute <strong>of</strong> Chemical and Biological Physics, Estonia<br />
1990-1998: researcher, Institute <strong>of</strong> Biotechnology, University <strong>of</strong> Helsinki, Finland 1999-present: researcher<br />
Chair <strong>of</strong> Pathophysiology, Institute <strong>of</strong> General and Molecular Pathology, University <strong>of</strong> Tartu,<br />
Estonia Administrative experience: - Honours and awards: - Membership in academic and scientific<br />
societies: Estonian Society <strong>of</strong> Biochemistry Current research program and grants: Cytosceleton-mitochondrial<br />
interactions; A new method in genome analysis, Estonian Technology Agency,<br />
grant 716 Kt; Grantholder: Ülo Puurand Supervision <strong>of</strong> dissertations: - Publications: 12 full length<br />
papers<br />
192
IMMUNOLOGY<br />
<strong>Name</strong> <strong>of</strong> <strong>the</strong> <strong>Department</strong>: <strong>Department</strong> <strong>of</strong> General and Molecular Pathology<br />
Head <strong>of</strong> <strong>the</strong> <strong>Department</strong>: Pr<strong>of</strong>essor Aavo-Valdur Mikelsaar<br />
<strong>Name</strong> <strong>of</strong> <strong>the</strong> Chair: Immunology<br />
Head <strong>of</strong> <strong>the</strong> Chair: Pr<strong>of</strong>essor Raivo Uibo<br />
Subject codes: ARMP.02.011; ARMP.02.016; ARMP.02.004;<br />
ARMP.02.005; ARMP.02.012; ARMP.02.013;<br />
ARMP.02.015<br />
I. CONTENT OF THE TEACHING<br />
1. Describe shortly <strong>the</strong> main study and student evaluation methods applied at<br />
<strong>the</strong> department.<br />
Teaching <strong>of</strong> basic and medical aspects <strong>of</strong> immunology is performed by lectures<br />
and seminars, but a lot <strong>of</strong> individual work is expected from students´<br />
side. Lectures are preceding subsequent seminars (at least a week). Permission<br />
to participate in seminars is achieved by successful performance <strong>of</strong> written<br />
control work concerning basic aspects <strong>of</strong> immunology (general terminology,<br />
cells and molecules <strong>of</strong> <strong>the</strong> immune system etc.). Most <strong>of</strong> <strong>the</strong> seminars are<br />
problem-based (autoimmunity, infection etc.). The last seminar (as an immunologic<br />
disease case seminar) is fully prepared and presented by students.<br />
Student participation in lectures is on voluntary basis, but <strong>the</strong> participation in<br />
seminars is obligatory. To get through in <strong>the</strong> course <strong>of</strong> immunology students<br />
must successfully perform written exam, which includes 1) questions with<br />
choice answers, 2) assay on a problem in basic immunology, and 3) assay on<br />
a problem related to an immune mediated disease. The elective studies dedicated<br />
for students interested in research include introductory lectures, seminars<br />
with tutors and individual work on a specific clinical immunology problem<br />
in <strong>the</strong> immunology research laboratory.<br />
2. How have <strong>the</strong> aims and objectives described in <strong>the</strong> curriculum changed<br />
during <strong>the</strong> past five years?<br />
The aims and objectives <strong>of</strong> immunology teaching were thoroughly redefined<br />
three years ago: 1) <strong>the</strong> number <strong>of</strong> lectures has been reduced which permits to<br />
shorten <strong>the</strong> course to 16 weeks; 2) elective studies were added to <strong>the</strong> basic<br />
course to involve students interested in immunology related research. During<br />
last two years (after moving into Biomedicum building) possibilities to use<br />
computers, multimedia as well as laboratory demonstrations during <strong>the</strong> course<br />
have been grown.<br />
3. Describe <strong>the</strong> strengths and weaknesses <strong>of</strong> <strong>the</strong> teaching in your department.<br />
Strengths<br />
• Use <strong>of</strong> teachers with good scientific background and everyday contact with<br />
clinical or laboratory problems <strong>of</strong> immunology (including personnel from <strong>the</strong><br />
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SECTION I: SELF-EVALUATION<br />
194<br />
United Laboratories <strong>of</strong> <strong>the</strong> Tartu University Clinic, <strong>Department</strong> <strong>of</strong> Pediatrics);<br />
• Use <strong>of</strong> problem-based and case seminars including <strong>the</strong> elements <strong>of</strong> problem-based<br />
learning;<br />
• Possibility to use computer-aided learning and knowledge control (for students<br />
knowing English);<br />
• Use <strong>of</strong> elective studies for students interested in immunology research; <strong>the</strong><br />
number <strong>of</strong> students interested in elective studies has been increasing continuously<br />
which shows that we have been able to rise students interest in<br />
immunology;<br />
• Availability <strong>of</strong> contemporary English textbooks <strong>of</strong> immunology in <strong>the</strong> Chair<br />
with possibility to lend <strong>the</strong>se during <strong>the</strong> course;<br />
• Written and oral evaluation <strong>of</strong> <strong>the</strong> course by students; based on this<br />
evaluation modifications have been introduced into <strong>the</strong> curriculum whenever<br />
found necessary;<br />
• Access to information on innovative aspects in immunology teaching by<br />
internet and by personal contacts with o<strong>the</strong>r teachers in different universities.<br />
Weaknesses<br />
• Teaching immunology during 4 th semester is not optimally arranged: when<br />
<strong>the</strong> basic aspects <strong>of</strong> immunology are easy to teach, it is more difficult to<br />
teach immunopathological and clinically oriented topics, because students<br />
have not enough basic knowledge in pathology and propedeutic courses<br />
on internal medicine; <strong>the</strong>refore sometimes <strong>the</strong> illustrating examples on<br />
lectures and seminars are not well understood by students;<br />
• There is no individual practical work in obligatory immunology course;<br />
• There is no Estonian contemporary textbook on immunology, but <strong>the</strong><br />
teachers are working on that (a compendium type book dealing with essentials<br />
<strong>of</strong> basic immunology and immunopathology); however, <strong>the</strong>re is a<br />
number <strong>of</strong> English textbooks in <strong>the</strong> Chair;<br />
• The number <strong>of</strong> students participating in elective studies is limited due to<br />
limits <strong>of</strong> students individual work space in <strong>the</strong> research laboratory; thus approximately<br />
one third <strong>of</strong> applicants could be only taken for elective studies;<br />
• Insufficient pedagogic training <strong>of</strong> some seminar tutors.<br />
4. Describe <strong>the</strong> innovations in your teaching.<br />
The lecture and seminar materials are continuously updated with new data according<br />
to scientific discoveries and clinical applications in immunology. If possible<br />
<strong>the</strong> new clinically important knowledge is transferred to seminars where<br />
subsequent practical demonstrations are performed. Although <strong>the</strong> lectures<br />
have always been supplied with handouts, <strong>the</strong> lecture materials are also available<br />
by internet in Biomedicum from this year. Students have also possibility to<br />
communicate with lecturers and tutors by internet. There is also a computer
IMMUNOLOGY<br />
equipped with English language tutorial CD-ROM on core material <strong>of</strong> <strong>the</strong><br />
course in <strong>the</strong> Chair (includes facilities <strong>of</strong> self-learning).<br />
5. <strong>Name</strong> <strong>the</strong> factors which most disturb teaching (excluding financial resources).<br />
The number <strong>of</strong> permanent teachers (pr<strong>of</strong>essor and assistant) is too small<br />
which limits very much <strong>the</strong>ir time free <strong>of</strong> teaching and <strong>the</strong>refore <strong>the</strong> possibilities<br />
to visit o<strong>the</strong>r academic and scientific institutions for fur<strong>the</strong>r pedagogic<br />
training and scientific work. There is <strong>the</strong> lack <strong>of</strong> time <strong>of</strong> whole staff involved in<br />
teaching due to high workload ei<strong>the</strong>r in research or in hospital<br />
II. EVALUATION OF TEACHING<br />
6. How is <strong>the</strong> quality <strong>of</strong> <strong>the</strong> teaching in your department evaluated? How are<br />
<strong>the</strong> content and <strong>the</strong> modes <strong>of</strong> <strong>the</strong> teaching changed on <strong>the</strong> basis <strong>of</strong> <strong>the</strong><br />
evaluation?<br />
• The content and quality <strong>of</strong> immunology course have been continuously<br />
analysed and evaluated by <strong>the</strong> teachers in relation to <strong>the</strong> goals <strong>of</strong> medical<br />
teaching in EU as well as in relation with immunology courses in o<strong>the</strong>r universities<br />
in Finland, Sweden and UK;<br />
• The evaluation <strong>of</strong> immunology course is done by students according <strong>the</strong><br />
general rules worked out in <strong>the</strong> Faculty some years ago, but depending on<br />
<strong>the</strong> problems raised additional written or oral evaluation is performed;<br />
• If <strong>the</strong> feedback from <strong>the</strong> students indicates that some lectures or seminars<br />
are evaluated unsatisfactory we discuss <strong>the</strong> problem and try to correct it;<br />
• The course evaluation by students and teachers feedback has resulted in<br />
continuous minor modifications in our curriculum; <strong>the</strong>se modifications are<br />
discussed with <strong>the</strong> staff at <strong>the</strong> beginning <strong>of</strong> each academic year.<br />
III. PEDAGOGIC TRAINING OF STAFF<br />
7. How many <strong>of</strong> <strong>the</strong> teachers have received pedagogic training?<br />
Assistant has participated on pedagogic and educational psychology training<br />
in form <strong>of</strong> course organised in <strong>the</strong> University <strong>of</strong> Tartu in 1997. Pr<strong>of</strong>essor has<br />
been a member <strong>of</strong> International Union <strong>of</strong> Immunological Societies Education<br />
Committee during 1995-1998 and participated on international meetings (<strong>the</strong><br />
latest AAI meeting in 2000, Seattle, WA) where several aspects <strong>of</strong> immunology<br />
teaching have been discussed. In addition, <strong>the</strong> chair is keeping close<br />
contacts with teachers <strong>of</strong> undergraduate immunology course at <strong>the</strong> MTC in <strong>the</strong><br />
Karolinska Institutet (Sweden), with whom <strong>the</strong> pedagogic aspects <strong>of</strong> teaching<br />
are continuously discussed.<br />
8. Is <strong>the</strong>re a need for fur<strong>the</strong>r pedagogic training?<br />
With no doubt continuous pedagogic training is needed for whole staff involved<br />
in <strong>the</strong> teaching, but <strong>the</strong> most urgent need for such training is among researchers<br />
and young personal with short term teaching tasks.<br />
195
SECTION I: SELF-EVALUATION<br />
IV. TEACHING RESOURCES<br />
9. Is <strong>the</strong>re a need for rearrangement <strong>of</strong> <strong>the</strong> teaching resources in your department?<br />
If so, how should this be done?<br />
There is no need for rearrangement <strong>of</strong> teaching resources in <strong>the</strong> Chair, but as<br />
yet mentioned <strong>the</strong>re is need for additional teacher to give for <strong>the</strong> o<strong>the</strong>rs <strong>the</strong><br />
possibility to take free semester for pedagogic training or research work.<br />
V. COORDINATION OF THE TEACHING<br />
10. How is <strong>the</strong> teaching co-ordinated with o<strong>the</strong>r departments? Indicate <strong>the</strong> departments<br />
that are closest to your department.<br />
During last renovation <strong>of</strong> <strong>the</strong> medical curriculum in <strong>the</strong> Faculty much <strong>of</strong> efforts<br />
have been done to coordinate <strong>the</strong> teaching between different departments.<br />
Thus for <strong>the</strong> present time studies in immunology are sufficiently well coordinated<br />
with medical biochemistry, anatomy and histology, physiology, microbiology<br />
and pathology (comparison <strong>of</strong> topics taught). However, sometimes <strong>the</strong><br />
coordination is not enough concerning <strong>the</strong> detailed content <strong>of</strong> <strong>the</strong> courses.<br />
Unfortunately, <strong>the</strong> coordination with courses at <strong>the</strong> clinical departments is not<br />
so good, except laboratory medicine.<br />
VI. FUTURE PLANS<br />
11. Future plans to improve <strong>the</strong> teaching given by <strong>the</strong> department.<br />
• to facilitate more students’ self-learning in way to introduce more problembased<br />
seminars, practical works and to diminish <strong>the</strong> number <strong>of</strong> lectures;<br />
• to produce <strong>the</strong> textbook on medical immunology in Estonian in order to encourage<br />
students’ to learn <strong>the</strong> basic immunology aspects by <strong>the</strong>mselves;<br />
• to introduce clinical immunology lectures and problem-based seminars into<br />
<strong>the</strong> curriculum (optimally on <strong>the</strong> 5 th year) combining teachers with basic<br />
and clinical background in <strong>the</strong> teaching process;<br />
196<br />
• to involve more students into elective course finding for <strong>the</strong>m additional<br />
laboratory space.
IMMUNOLOGY<br />
Immunology: resource evaluation<br />
1. Study materials<br />
- How many study books are published in your institution during last five years? 0<br />
- Do you have separate room as library in your place? Yes No<br />
- Could students borrow study books from your institution? Yes No<br />
- Do you have on-line published study materials for students? Yes No<br />
- WWW address: http://biomedicum.ut.ee/armp/<br />
- Does University library has enough modern books in your speciality?<br />
Completely enough Enough Scarcely Absolutely scarcely No<br />
2. Amount and size <strong>of</strong> study rooms<br />
- Rooms used by Your institution only: 11 rooms with area <strong>of</strong> 190 m 2<br />
- Rooms shared with ano<strong>the</strong>r institution: 3 rooms with area <strong>of</strong> 60 m 2<br />
- Do You have enough space for study process by Your opinion?<br />
Completely enough Enough Scarce Absolutely scarcely<br />
- How <strong>the</strong> scarce <strong>of</strong> space should be handled or changed?<br />
New building Change to smaller student groups Better logistics<br />
O<strong>the</strong>r way (describe shortly)<br />
3. Current situation <strong>of</strong> study rooms<br />
- There has been repairments in last 4 years (except Biomedicum)<br />
- How are <strong>the</strong> study rooms lightened?<br />
Very good Good Some darkness Absolutely dark for study<br />
- Evaluation <strong>of</strong> general conditions: Very good Good Satisfactory Bad<br />
4. Your institution has<br />
a) one auditorium for workshops/seminars with 20 places, equipped with<br />
Blackboard<br />
White board & markers<br />
Screen<br />
Overhead projector<br />
Data projector<br />
Slide projector<br />
b) one laboratory for practicals with 24 places, equipped with<br />
Blackboard<br />
White board and markers<br />
Screen<br />
Overhead projector<br />
Data projector<br />
Slide projection kit<br />
TV/Video projection set<br />
Computer<br />
Internet connection<br />
TV/Video projection kit<br />
Computer<br />
Internet connection<br />
5. Working rooms for teaching staff and postgraduate students:<br />
- Number <strong>of</strong> teaching staff 12<br />
- Number <strong>of</strong> rooms for staff 3<br />
- Number <strong>of</strong> individual working places 7, among <strong>the</strong>m with computers 3<br />
- Number <strong>of</strong> postgraduate students is 1 (registered)<br />
- How many individual working places <strong>the</strong>y have? 1<br />
- How many computers <strong>the</strong>y have? 1<br />
6. O<strong>the</strong>r comments on resource topic (max 250 letters): Teaching staff for immunology<br />
course includes 4 persons from <strong>the</strong> chair and 2 from elsewhere. All staff is teaching in<br />
elective (obligatory) courses; this is performed in our research laboratory (5 rooms). A<br />
total <strong>of</strong> 5 persons are working on <strong>the</strong>ir doctoral and master degree dissertations at <strong>the</strong><br />
chair.<br />
197
SECTION I: APPENDIXES<br />
APPENDIX I-I<br />
Visits <strong>of</strong> <strong>the</strong> Chair members to o<strong>the</strong>r institutions abroad during 1996-2000<br />
Year Researcher/Lectures Institution Country Purpose Duration<br />
1999 Kai Kisand University <strong>of</strong> Tampere Finland studying RT-PCR for enterovirus<br />
detection<br />
2000 Kai Kisand University <strong>of</strong> Turku Finland studying lymphocyte proliferation<br />
assay<br />
2000 Kai Kisand University <strong>of</strong> Kiel Germany Summer School and practical<br />
course<br />
198<br />
1 week<br />
1 week<br />
3 weeks<br />
1996 Kaja Metsküla Karolinska Institute Sweden Research 1 week<br />
1998 Kaja Metsküla Staten Serum Institute Denmark Research 1 week<br />
1996 Kaupo Teesalu University <strong>of</strong> Tampere Finland practical course 1 week<br />
1998 Kaupo Teesalu Wallac OY, Turku Finland customer training 1 week<br />
1996 Koit Reimand University <strong>of</strong> Tampere Finland Research, teaching 1 month<br />
2000 Koit Reimand University <strong>of</strong> Tampere Finland Research 2 months<br />
1997 Koit Reimand University <strong>of</strong> Tampere Finland Research 6 months<br />
1999 Koit Reimand University <strong>of</strong> Tampere Finland Research 2 months,<br />
3 weeks<br />
1997 Liina Salur University <strong>of</strong> Oulu Finland Studying ICA determination 1 week<br />
1999 Liina Salur Latvia Summer School 1 week<br />
1999 Liina Salur University <strong>of</strong> Turku Finland training course 1 week<br />
2000 Liina Salur University <strong>of</strong> Turku Finland studying lymphocyte proliferation 1 week<br />
assay<br />
2000 Liina Salur University <strong>of</strong> Oulu Finland studying GADA, IA-2, IAA 10 days<br />
1998 Maire Mandel Wallac OY, Turku Finland customer training 1 week<br />
1996 Raivo Uibo University <strong>of</strong> Tampere Finland Research, teaching 1 month<br />
1996 Raivo Uibo Karolinska Institute Sweden Research, study <strong>of</strong> curriculum 1 week<br />
1997 Raivo Uibo University <strong>of</strong> Tampere Finland Research 1 week<br />
1998 Raivo Uibo Harvard University USA Research 1 week<br />
1998 Raivo Uibo University <strong>of</strong> Tampere Finland Research 1 week<br />
1999 Raivo Uibo University <strong>of</strong> Turku Finland Research, study <strong>of</strong> curriculum 1 week<br />
2000 Raivo Uibo Pennislvania University USA Research 1 week<br />
2000 Raivo Uibo Karolinska Institute Sweden Research, study <strong>of</strong> curriculum 1 week<br />
1998 Reet Kuuse University <strong>of</strong> Groningen Netterlands studies clinical immunology 4 weeks<br />
1999 Reet Kuuse Who Research and Training<br />
Centre Lausanne<br />
Switzerland studies vaccinology & immunology<br />
6 weeks<br />
1996 Tamara Vorobjova University <strong>of</strong> Lund Sweden Research 1 month<br />
1997 Tamara Vorobjova Salzburg-Cornell Austria Seminar 1 week<br />
1998 Tamara Vorobjova University <strong>of</strong> Stockholm Sweden Summer School 10 days<br />
1998 Tamara Vorobjova University <strong>of</strong> Erlangen Germany Research 2 months<br />
1999 Tamara Vorobjova Latvia Summer School 1 week
APPENDIX I-II<br />
IMMUNOLOGY<br />
Postgraduate students at <strong>the</strong> <strong>Department</strong> having studied abroad during 1996-2000<br />
Year <strong>Name</strong> Institution Contry Duration<br />
1996 K.Metsküla Karolinska Institutet Sweden 1 week<br />
1997 K.Hirv Lübeck Medical University Germany 10 months<br />
1997 L.Salur University <strong>of</strong> Oulu Finland 1 week<br />
1998 K.Metsküla Statens Seruminstitut Denmark 1 week<br />
1999 L.Salur University <strong>of</strong> Turku Finland 1 week<br />
2000 L.Salur University <strong>of</strong> Oulu Finland 10 days<br />
APPENDIX I-III<br />
Co-operation with institutions from o<strong>the</strong>r countries and participation in international<br />
research projects during 1996-2000<br />
Contact person Institution Country Aim<br />
Pr<strong>of</strong>.R.Uibo University <strong>of</strong> Tampere Finland Research and teaching<br />
Pr<strong>of</strong>.R.Uibo University <strong>of</strong> Turku Finland Research<br />
Pr<strong>of</strong>.R.Uibo University <strong>of</strong> Pennsylvania USA Research<br />
Pr<strong>of</strong>.R.Uibo University <strong>of</strong> Lund Sweden Research<br />
Pr<strong>of</strong>.R.Uibo University <strong>of</strong> California at Davis USA Research<br />
Pr<strong>of</strong>.R.Uibo University <strong>of</strong> Washington USA Research<br />
Pr<strong>of</strong>.R.Uibo Karolinska Institutet Sweden Teaching<br />
Sen.researcher T.Vorobjova University <strong>of</strong> Bern Switzerland Research<br />
Sen.researcher T.Vorobjova University <strong>of</strong> Lund Sweden Research<br />
Sen.researcher T.Vorobjova University <strong>of</strong> Erlangen Germany Research<br />
APPENDIX I-IV<br />
Visiting lecturers at <strong>the</strong> <strong>Department</strong> during 1996-2000<br />
Visitor Institution Country Purpost<br />
Pr<strong>of</strong>.V.Tamosiunas University <strong>of</strong> Vilnius Lithuania Research and teaching<br />
Doc.H.Hyöty University <strong>of</strong> Tampere Finland Research and teaching<br />
Doc.J.Ilonen University <strong>of</strong> Turku Finland Research and teaching<br />
Pr<strong>of</strong>.M.Seyfarth Medical University <strong>of</strong> Lübeck Germany Research<br />
Pr<strong>of</strong>.P.Janmey Harvard University USA Research<br />
Dr.G.Faller University <strong>of</strong> Erlangen Germany Research<br />
Pr<strong>of</strong>.T.Palosuo National Public Health Institute Finland Research<br />
Doc.P.Peterson University <strong>of</strong> Tampere Finland Research and teaching<br />
APPENDIX I-V<br />
Scientific journals available at <strong>the</strong> Chair<br />
No <strong>Name</strong> <strong>of</strong> Journal Version<br />
1. Central European Journal <strong>of</strong> Immunology paper<br />
2. Current Opinion in Immunology paper, online<br />
3. Nature Immunology paper, online<br />
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SECTION I: APPENDIXES<br />
APPENDIX I-VI<br />
Publications <strong>of</strong> <strong>the</strong> <strong>Department</strong> members during 1996-2000<br />
MONOGRAPHS<br />
1. Kisand K. Autoantibodies to 2-oxoacid dehydrogenase complexes. Detection and significance in<br />
primary biliary cirrhosis. Tartu, Tartu University Press 1999<br />
PAPERS IN INTERNATION JOURNALS<br />
1. Kisand K, Karvonen A.-L, Vuoristo M, Färkkilä M, Lehtola J, Inkovaara J, Kisand K, Miettinen T,<br />
Krohn K, Uibo R (1996): Ursodeoxycholic acid treatment lowers <strong>the</strong> serum level <strong>of</strong> antibodies<br />
against pyruvate dehydrogenase and influences <strong>the</strong>ir inhibitory capacity for <strong>the</strong> enzyme complex in<br />
patients with primary biliary cirrhosis. J Mol Med 74, 269 - 274<br />
2. Uibo O, Metsküla K, Kukk T, Rägo T, Uibo R (1996): Results <strong>of</strong> coeliac disease screening in Estonia<br />
in 1990 – 1994. Acta Paediatr Suppl 412: 39 - 41<br />
3. Remmel T, Piirsoo A, Koiveer A, H. Remmel H, Uibo R, Salupere V (1996): Clinical Significance <strong>of</strong><br />
Different Antinuclear Antibodies Patterns in <strong>the</strong> Course <strong>of</strong> Primary Biliary Cirrhosis. Hepato-<br />
Gastroenterology 43: 1135-1140.<br />
4. Peterson P, Uibo R, Peränen J, Krohn K(1997): Immunoprecipitation <strong>of</strong> steroidogenic enzyme<br />
autoantigens with autoimmune polyglandular syndrome type I (APS I) sera; fur<strong>the</strong>r evidence forindipendent<br />
humoral immunity to P450c21. Clin Exp Immunol 107:335-340.<br />
5. Uibo R, Uibo O, Reimand K, Peterson P, Krohn K (1997): Characterization by molecular cloning an<br />
antigen reactive with antireticulin antibodies. Ann New York Acad Sci 815:509-11.<br />
6. Turchany JM, Uibo R, Kivik T, Van de Water J, Prindiville T, Coppel RL, Gershwin ME (1997): A<br />
study <strong>of</strong> antimitochondrial antibodies in a random population in Estonia. Amer J Gastroenterol<br />
92:124-6.<br />
7. Mägi A, Sumitran-Karuppan S, Peetsalu A, Uibo R (1997): Early expression <strong>of</strong> CD69 in allogeneic<br />
cell activation. Central - European J Immunol 22: 86-93.<br />
8. Ots M, Salupere V, Uibo R. (1997): Regional incidence <strong>of</strong> rapidly progressive glomerulonephritis in<br />
Estonia. Nephrol Dial Transplant 12: 2794-6.<br />
9. Sipria A, Kokk K, Talvik R, Uibo R (1997): Changes in endogenous anti endotoxin core antibodies<br />
and TNF-α in septic patients with MOF. In:Proceedings <strong>of</strong> 4 th International Congress on <strong>the</strong> Immune<br />
Consequences <strong>of</strong> Trauma, Shock and Sepsis. Munich: 27-29.<br />
10. Kull K, Salupere R, Uibo R, Ots M, Salupere V (1998): Antineutrophil cytoplasmic antibodies in<br />
Estonian patients with inflammatory bowel disease. Prevalence and diagnostic role. Hepato-<br />
Gastroenterology 45: 2132-7.<br />
11. Kemp EH, Ajjan RA, Husebye ES, Peterson P, Uibo R, Imrie H, Pearce SH, Watson PF, Weetman<br />
AP (1998): A cytotoxic T lymphocyte antigen-4 (CTLA-4) gene polymorphism is associated with<br />
autoimmune Addison's disease in English patients.Clin Endocrinol 49: 609-13.<br />
12. Vorobjova T, Nilsson I, Kull K, Maaroos HI, Covacci A, Wadstrom T, Uibo R. (1998) CagA protein<br />
seropositivity in a random sample <strong>of</strong> adult population and gastric cancer patients in Estonia. Eur J<br />
Gastroenterol Hepatol. 10: 41-6.<br />
13. Vorobjova T, Maaroos H-I, Rägo T, Zimmermann A, Uibo R (1998): Helicobacter pylori (H. pylori) in<br />
gastric mucosa <strong>of</strong> children with abdominal complaints: immunohistochemistry detects antigenreactive<br />
corpus mucosa cells. Helicobacter 3: 103-109.<br />
14. Uibo R, Talja I, Jõgi R, Janson C, Björnsson E, Boman G, Mandel M, Björksten B (1998): Autoantibodies<br />
in Estonia and Sweden, populations with different responses to allergens. Int Arch Allergy<br />
Immunol 117: 126-130.<br />
15. Kisand KE, Kisand KV, Karvonen A-L, Vuoristo M, Mattila J, Mäkinen J, Uibo R (1998): Antibodies<br />
to pyruvate dehydrogenase in primary biliary cirrhosis: correlation with histology. APMIS 106: 884-<br />
892.<br />
16. Metsküla K., Grünberg H., Uibo O., Talja I., Uibo R. (1998): Antigliadin antibodies and autoantibodies<br />
among 9, 12 and 15 years old schoolchildren. Central-European Journal Immunol 23: 197-<br />
202.<br />
17. Kull K, Uibo O, Salupere R, Metsküla K, Uibo R (1999): High frequency <strong>of</strong> antigliadin antibodies<br />
and absence <strong>of</strong> antireticulin and antiendomysium antibodies in patients with ulcerative colitis. J<br />
Gastroenterol 34: 61-65.<br />
18. Ots M, Uibo O, Metsküla K, Uibo R, Salupere V (1999): Iga-Antigliadin antibodies in patients with<br />
IgA nephropathy: The secondary phenomenon? The Amer J Nephrol 19: 453-458.<br />
200
IMMUNOLOGY<br />
19. Juhela S, Hyöty H, Uibo R, Meriste SH, Uibo O, Lönnrot M, Halminen M, Simell O, Ilonen J (1999):<br />
Comparison <strong>of</strong> enterovirus-specific cellular immunity in two populations <strong>of</strong> young children vaccinated<br />
with inactivated or live poliovirus vaccines. Clin Exp Immunol 117: 100-105.<br />
20. Maaroos H-I, Vorobjova T, Sipponen P, Tammur R, Uibo R, Wadström T, Keevallik R, Villako K<br />
(1999): An 18-year follow-up study <strong>of</strong> chronic gastritis and Helicobacter pylori: Association <strong>of</strong> CagA<br />
positivity with development <strong>of</strong> atrophy and activity <strong>of</strong> gastritis. Scand J Gastroenterol 34: 864-869.<br />
21. Hirv K, Seyfarth M, Uibo R, Kull K, Salupere R, Latza U, Rink L (1999): Polymorphisms in tumour<br />
necrosis factor and adhesion molecule genes in patients with inflammatory bowel disease; associations<br />
with HLA-DR, -DQ alleles and subclinical markers. Scand J Gastroenterol 34: 1025-1032.<br />
22. Prükk T, Kisand K, Salur L, Metsküla K, Uibo R (1999): Seroprevalence for tick-borne Lyme borreliosis<br />
in a defined population in Estonia. Scand J Inf Dis 31: 421-422.<br />
23. Uibo R, Salupere V (1999): The epidemiology <strong>of</strong> primary biliary cirrhosis: Immunological problems.<br />
Hepato-Gastroenterology 46: 3048-3052.<br />
24. Quaranta S, Van de Water J, Ishibashi H, Rosina F, Coppel R, Uibo R, Gershwin ME (1999): The<br />
immunopathogenesis <strong>of</strong> primary biliary cirrhosis. Hepato-Gastroenterology 46: 3053-3059.<br />
25. Kallikorm R, Uibo O, Uibo R (2000): Coeliac disease in spondyloarthropathy: usefulness <strong>of</strong> serological<br />
screening. Clin Rheumatol 19: 118-22.<br />
26. Ots M, Kulla A, Luman M, Metsküla K, Leiba V, Ritz E (2000): Non-diabetic nodular glomerulosclerosis<br />
recurring in a renal graft - Nephrol Dial Transpl 15: 2053-2056.<br />
27. Peterson P, Uibo R, Krohn K (2000): Adrenal autoimmunity: Results and developments - Trends<br />
Endocrinol Metab 11: 285-290.<br />
28. Reimand K, Peterson P, Hyöty H, Uibo R, Cooke I, Weetman A, Krohn K (2000): 3betahydroxysteroid<br />
dehydrogenase autoantibodies are rare in premature ovarian failure. J Clin Endocrinol<br />
Metab 85: 2324-2326.<br />
29. Salur L, Uibo O, Talvik I, Justus I, Metsküla K, Talvik T, Uibo R (2000): The high frequency <strong>of</strong> coeliac<br />
disease among children with neurological disorders. Europ J Neurol 7: 707-711.<br />
30. Vorobjova T, Grünberg H, Oona M, Maaroos H, Nilsson I, Wadström T, Covacci A, Uibo R (2000):<br />
Seropositivity to Helicobacter pylori and CagA protein in schoolchildren <strong>of</strong> different ages living in<br />
urban and rural areas in sou<strong>the</strong>rn Estonia. Europ J Gastroenterol Hepatol 12: 97-101.<br />
31. Vorobjova T, Faller G, Maaroos H, Sipponen P, Villako K, Uibo R, Kirchner T (2000): Significant increase<br />
in antigastric autoantibodies in a long-term follow-up study <strong>of</strong> H.pylori gastritis - Virchows<br />
Arch 437: 37-45.<br />
32. Wang L, Gorlin J, Michaud S, Janmey P, Goddeau R, Kuuse R, Uibo R, Adams D, Sawyer E<br />
(2000):Purification <strong>of</strong> salmon clotting factors and <strong>the</strong>ir use as tissue sealants. Thromb Res 100:<br />
537-548.<br />
PAPERS IN ESTONIAN JOURNALS<br />
1. Kisand K, Kisand K, Karvonen A-L, Krohn K, Uibo R (1997): Autoantibodies in primary biliary cirrhosis.<br />
Eesti Arst No. 6, 494-498 (in Estonian).<br />
2. Uibo R (1999): The mechanism <strong>of</strong> autoimmune disease development and immunodiagnostics.<br />
Eesti Vabariigi teaduspreemiad. Tallinn, A/S Infotrükk: 32-40 (in Estonian).<br />
3. Kull K, Salupere R, Metsküla K, Uibo R (2000): Autoantibodies occurrence and significance <strong>of</strong><br />
autoantibodies in inflammatory bowel diseases. Eesti Arst No. 1: 12-16 (in Estonian).<br />
4. Uibo O, Shor R, Paal M, Kulla A, Metsküla K (2000): The diagnosis <strong>of</strong> coeliac disease in a patient<br />
with diabetes mellitus after two year period. Case report. Eesti Arst No. 11: 690-693 (in Estonian).<br />
SUBMITTED PAPERS<br />
1. Kisand KE, Metsküla K, Kisand KV, Kivik T, Gershwin ME, Uibo R (2001): The follow-up <strong>of</strong><br />
asymptomatic persons with antibodies to pyruvate dehydrogenase in adult population samples. J<br />
Gastroenterol 36: (in press).<br />
2. Vorobjova T, Ananieva O, Maaroos H-I, Sipponen P, Villako V, Utt M, Nilsson I, Wadström T, Uibo<br />
R (2001): Seropositivity to Helicobacter pylori heat shock protein 60 is strongly associated with intensity<br />
<strong>of</strong> chronic inflammation, particularly in antrum mucosa: an extension <strong>of</strong> an 18-year follow-up<br />
study <strong>of</strong> chronic gastritis in Saaremaa, Estonia. FEMS Immunol Med Microbiol 1299: (in press).<br />
3. Vorobjova T, Maaroos H-I, Sipponen P, Villako K, Uibo R (2001). Apoptosis in different compartments<br />
<strong>of</strong> antrum and corpus mucosa in chronic Helicobacter pylori gastritis. An 18-year follow-up<br />
study. Scand J Gastroenterol 36: (in press).<br />
4. Uibo R, Sullivan EP, Uibo O, Lernmark A, Salur L, Kivik T, Mandel M (2001): Comparative study <strong>of</strong><br />
glutamic acid decarboxylase autoantibodies and antigliadin antibodies in a random adult population<br />
sample. Horm Metab Res (submitted).<br />
201
SECTION I: APPENDIXES<br />
5. Liiv I, Teesalu K, Peterson P, Clemente MG, Perheentupa J, Uibo R (2001): Epitope mapping <strong>of</strong><br />
cytochrome P450 cholesterol side-chain cleavage enzyme (P450scc) by sera from patients with<br />
autoimmune polyglandular syndrome type 1. J Clin Endocrinol Metab (submitted).<br />
6. Teesalu K, Uibo O, Kalkkinen N, Janmey P, Uibo R (2001): Increased levels <strong>of</strong> IgA antibodies<br />
against desmin in children with coeliac disease. Int Arch Allergy Immunol (submitted).<br />
202
APPENDIX I-VII<br />
Academic and administrative personnel: Chair <strong>of</strong> Immunology<br />
IMMUNOLOGY<br />
<strong>Name</strong> Title Load Area Gender Birth year Scientific degree Year <strong>of</strong> commencement Labour time (y)<br />
1. Raivo Uibo Pr<strong>of</strong>essor 1,00 Immunology Male 1948 Ph.D, Dr.Sci 1992 27<br />
2. Koit Reimand Assistant 1,00 Immunology Male 1968 6<br />
3. Kalle Kisand Sr. Researcher 1,00 Immunology Male 1961 Cand.Sci 1990 15<br />
4. Tamara Vorobjova Sr. Researcher 1,00 Immunology Female 1955 Cand.Sci 1985 21<br />
5. Kai Kisand Researcher 1,00 Immunology Female 1965 Dr.Med 1999 11<br />
6. Ingrid Liiv Researcher 1,00 Immunology Female 1970 M.Sc 1997 8<br />
7. Maire Mandel Sr. Engineer 1,00 Female 1962 5<br />
8. Kaja Metsküla Sr. Technical staff 1,00 Female 1960 7<br />
9. Kaupo Teesalu Sr. Technical staff 1,00 Male 1971 4<br />
10. Ija Talja Sr. Technical staff 0,50 Female 1967 M.Sc 1999 8<br />
11. Reet Kuuse Sr. Technical staff 0,50 Female 1961 5<br />
12. Liina Salur Sr. Technical staff 0,50 Female 1961 5<br />
1 Cand.Sci & Dr.Sci are degrees <strong>of</strong> <strong>the</strong> Former Soviet Union which correspond to a Ph.D and Dr.Med, respectively<br />
203
APPENDIX I-VIII<br />
Curriculum Vitae <strong>of</strong> <strong>the</strong> staff<br />
IMMUNOLOGY<br />
UIBO, RAIVO Date <strong>of</strong> birth: Dec 21, 1948 Gender: Male Citizenship: Estonian Address: Ravila 19,<br />
Tartu 51014 (work), Taara pst 28., Tartu 51006 (home) Educational history: Licentiate <strong>of</strong> Medicine<br />
(M. D.), Medical Faculty, University <strong>of</strong> Tartu Academic degrees (with year and university): 1973 -<br />
Licentiate <strong>of</strong> Medicine (M. D.), University <strong>of</strong> Tartu; 1978 – Candidate <strong>of</strong> Medicine, University <strong>of</strong> Tartu; 1985<br />
– Senior Researcher, University <strong>of</strong> Tartu; 1990 – Doctorate <strong>of</strong> Medicine, University <strong>of</strong> Tampere, Finland,<br />
and 1991 - All-Union Committee <strong>of</strong> Academic degrees; 1993 – Docent <strong>of</strong> Immunopathology,<br />
University <strong>of</strong> Tampere, Finland Employment and pr<strong>of</strong>essional experience: Research assistant and<br />
junior researcher, Medical Faculty, University <strong>of</strong> Tartu, 1973-1979; Head, Laboratory <strong>of</strong> Immunology,<br />
Institute <strong>of</strong> General and Molecular Pathology, University <strong>of</strong> Tartu, 1979-1992 (Senior researcher in<br />
immunology and allergology, since 1985). Pr<strong>of</strong>essor <strong>of</strong> Immunology, University <strong>of</strong> Tartu, since 1992.<br />
Foreign studies and activities: Visiting Scientist and Lecturer, <strong>Department</strong> <strong>of</strong> Pathology, University <strong>of</strong><br />
Tampere, Finland, 1990-1993 (8 moths); Visiting Lecturer, University <strong>of</strong> Sheffield, U.K., 1993; Visiting<br />
Scientist, Laboratory <strong>of</strong> Molecular Genetics, IRIBHN, University <strong>of</strong> Brussels, Belgium, January-April, 1994;<br />
Visiting Pr<strong>of</strong>essor, Institute <strong>of</strong> Medical Technology, October-November, 1996; Visiting Scientist in<br />
Harvard and Pennsilvania Universities (2 weeks 1999-2000); particiption in several international<br />
congresses and symposia on immunology Administrative experience: Head <strong>of</strong> <strong>the</strong> Immunology<br />
Research Group and <strong>the</strong> Head <strong>of</strong> Curriculum in Immunology at <strong>the</strong> Institute <strong>of</strong> General and Molecular<br />
Pathology, University <strong>of</strong> Tartu since 1992; Coordinator <strong>of</strong> <strong>the</strong> research project TARMP0420, PI <strong>of</strong> <strong>the</strong><br />
Estonian Science Foundation grants No. 267, 1075, 1339, 3045 (1993-2000), Open Estonia<br />
Foundation grant “Development <strong>of</strong> medical immunology in Estonia” (1996), grant “Environment and<br />
immune system” <strong>of</strong> <strong>the</strong> Ministry <strong>of</strong> Social Affairs (1997), Estonian co-ordinator <strong>of</strong> <strong>the</strong> EU Biomed 2<br />
Concerted Action project PL950729 (1996-1999), Estonian co-ordinator <strong>of</strong> <strong>the</strong> EU INCO-Copernicus<br />
grant IC15CT96-0916 “Novel diagnostics and <strong>the</strong>rapy in Addison’s disease and related autoimmunity”<br />
(1997-2000), Scientific co-ordinator <strong>of</strong> <strong>the</strong> EU INCO-Copernicus grant IC15CT98-0316 “Enterovirus<br />
infections in NIS/CEE countries and in EU – importance for population health and pathogenesis <strong>of</strong><br />
IDDM” (1999-2002). Organization <strong>of</strong> <strong>the</strong> international courses (in Tartu, 1994, 2001 - Chairman <strong>of</strong> <strong>the</strong><br />
Organization Committee; in Palanga, 1993, in Trakai, 1995, in Riga 1995, 1999 - member <strong>of</strong> <strong>the</strong><br />
Organization Committees). Head <strong>of</strong> <strong>the</strong> Commission <strong>of</strong> Pr<strong>of</strong>essional Expertise at <strong>the</strong> Medical Faculty,<br />
University <strong>of</strong> Tartu (1994-1996); Member <strong>of</strong> <strong>the</strong> Board <strong>of</strong> Academic degrees at <strong>the</strong> Medical Faculty<br />
(1997-1999), Member <strong>of</strong> different boards on teaching, institutional development etc. at <strong>the</strong> Medical<br />
Faculty (1997-2001); Council member <strong>of</strong> <strong>the</strong> Estonian Science Foundation and <strong>the</strong> Chairman <strong>of</strong> <strong>the</strong><br />
Group <strong>of</strong> Experts in Medicine (from 2000). Honours and awards: USA National Institutes <strong>of</strong> Health<br />
FIRCA Grant R03 TW00787; Scientific Awards <strong>of</strong> <strong>the</strong> Estonian Government in 1995 and 1999.<br />
Membership in academic and scientific societies: Member <strong>of</strong> International Union <strong>of</strong> Immunological<br />
Societies Educational Committee (since 1995), Member <strong>of</strong> Clinical Immunology Group <strong>of</strong> European<br />
Federation <strong>of</strong> Immunological Societies (since 1998), first Chairman <strong>of</strong> Estonian Society for<br />
Immunology (1984-1995), Vice-Chairman <strong>of</strong> Baltic Immunologic Society (1992-1995); Founding<br />
Member <strong>of</strong> Euroscience (1997), Member <strong>of</strong> <strong>the</strong> Editorial Boards <strong>of</strong> <strong>the</strong> Central-European Journal <strong>of</strong><br />
Immunolog and <strong>the</strong> Russian Journal <strong>of</strong> Immunology, Member <strong>of</strong> Euroscience, Member <strong>of</strong> <strong>the</strong> Society<br />
for Mucosal Immunology and <strong>of</strong> <strong>the</strong> International Association for <strong>the</strong> Study <strong>of</strong> <strong>the</strong> Liver. Current<br />
research program and grants: Coordinator <strong>of</strong> <strong>the</strong> research project TARMP0420 “Pathogenetic<br />
mechanisms <strong>of</strong> autoimmunity and immunodiagnostics” (Ministry <strong>of</strong> Education 1998-2002), Estonian<br />
Science Foundation grant No. 4437 “ Mechanisms <strong>of</strong> autoimmunity development in Down’s syndrome”<br />
(2000-2002), EU INCO-Copernicus grant IC15CT98-0316 “Enterovirus infections in NIS/CEE countries<br />
and in EU – importance for population health and pathogenesis <strong>of</strong> IDDM” (1999-2002). Supervision<br />
<strong>of</strong> dissertations: Kalle Kisand (Cand. med, 1990); Triin Remmel (Dr. med Sci, 1996); Mai Ots (Dr. med.<br />
Sci, 1998); Kaja Julge (Dr. med. Sci, 1998); Kai Kisand (Dr. med. Sci, 1999), Ija Talja (M Biomed Sci,<br />
1999); Kaimo Hirv (Dr. med. Sci., 2000, Lübeck – co-supervisor). Publications (1996-2001): 67 (incl. 35<br />
papers published or in press in international peer reviewed journals; 5 submitted papers; 4 papers in<br />
local journals; 23 abstracts <strong>of</strong> conference presentations).<br />
KISAND, KALLE Date <strong>of</strong> birth: November 22, 1961 Gender: male Citizenship: Estonian Address:<br />
Immunology Research Group, Institute <strong>of</strong> General and molecular Pathology, University <strong>of</strong> Tartu. Ravila<br />
19, Tartu 51014, Estonia Educational history: Licentiate <strong>of</strong> Medicine (M.D.), University <strong>of</strong> Tartu,<br />
Estonia, 1985; 1985-1988 postgraduate studies, University <strong>of</strong> Tartu Academic degrees: PhD,<br />
Moscow II Medical Institute, Russia, 1990 Employment and pr<strong>of</strong>essional experience: 1988-1990 -<br />
junior researcher in Laboratory <strong>of</strong> Immunology, University <strong>of</strong> Tartu; 1990-1992 - researcher in<br />
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SECTION I: APPENDIXES<br />
Laboratory <strong>of</strong> Immunology, University <strong>of</strong> Tartu; 1992-1995, 2001 up to now – senior researcher in<br />
Immunology Research Group by Institute <strong>of</strong> General and Molecular Pathology, University <strong>of</strong> Tartu;<br />
1991- Fellowship at <strong>the</strong> <strong>Department</strong> <strong>of</strong> Medical Microbiology, University <strong>of</strong> Lund, Sweden (three<br />
months); 1994 - International course "Autoimmunity: Basic and Clinical" (Tartu); experience <strong>of</strong><br />
teaching immunology from 1992 (lectures, seminars) Administrative experience: Member <strong>of</strong> local<br />
organizing committees: 1 st Estonian Congress <strong>of</strong> Immunology (1989); International Course<br />
″Autoimmunity: Basic and Clinical″ (1994); Co-ordinator <strong>of</strong> Estonian Health Project (1995-2000);<br />
Honours and awards: Award <strong>of</strong> medical faculty, University <strong>of</strong> Tartu, 1985; Scientific Award <strong>of</strong> Ministry<br />
<strong>of</strong> Education <strong>of</strong> Estonia, 1994. Membership in academic and scientific societies: President <strong>of</strong><br />
Estonian Immunological Society; President <strong>of</strong> Baltic Immunnological Society Current research<br />
program and grants Atoimmune diseases and infection. Grants: Ministry <strong>of</strong> education TARMP0420<br />
Pathogenetic mechanisms <strong>of</strong> autoimmunity and immunodiagnostics (1998-2002); Estonian Science<br />
Foundation grant No. 3045 Development <strong>of</strong> novel methods for <strong>the</strong> diagnosis <strong>of</strong> autoimmunity (1997-<br />
2000) Supervision <strong>of</strong> dissertations: No Publications: 9 (incl. 6 scientific papers )<br />
VOROBJOVA, TAMARA Date <strong>of</strong> birth: 5 July 1955 Gender: female Citizenship: Estonian 5. Address:<br />
work: 19, Ravila, Immunology Rsearch Group, University <strong>of</strong> Tartu, EE51014 Tartu, Estonia, Tel: 327-374<br />
230, FAX: 372-7-374 232 , e-mail: tamara.vorobjova@kliinikum.ee, e-mail: tamara@imlab.ut.ee; home:<br />
Mõisavahe 43-42, 50708 Tartu, Estonia. Educational history: Narva 7. Secondary School 1962-1972;<br />
University <strong>of</strong> Tartu, Medical Faculty 1972-1978; Post-graduate training in Taru University Hospital 1978-<br />
1979; Diploma (cum laude) in internal diseases (M.D.), University <strong>of</strong> Tartu, Estonia, 1978; Knowledge <strong>of</strong><br />
languages: Estonian, Russian, English, German, French, Italian. Academic degree: Cand. Sci. (medicine,<br />
internal diseases). Academic Dissertation, University <strong>of</strong> Tartu, Estonia, 1985 Employment: Post-graduate<br />
training in Tartu University Hospital, 1978-1979; Research Assistant, Laboratory <strong>of</strong> Immunology,<br />
Institute <strong>of</strong> General and Molecular Pathology, University <strong>of</strong> Tartu, Estonia, 1979-1981; Junior<br />
Researcher, Laboratory <strong>of</strong> Immunology, Institute <strong>of</strong> General and Molecular Pathology, University <strong>of</strong><br />
Tartu, Estonia, 1981-1993; Current position: Senior Researcher in Immunology, Immunology<br />
Research Group, Institute <strong>of</strong> General and Molecular Pathology, University <strong>of</strong> Tartu, Estonia, since<br />
1993; Lecturer <strong>of</strong> Immunology, University <strong>of</strong> Tartu, Estonia, since 1992 (teaching in estonian, russian<br />
and english languages). Pr<strong>of</strong>essional experience: Visiting scientist in <strong>the</strong> Institute <strong>of</strong> Pathology,<br />
University <strong>of</strong> Leipzig; in <strong>the</strong> Institute <strong>of</strong> Clinical Immunology, University <strong>of</strong> Jena; in <strong>the</strong> Institute <strong>of</strong><br />
Pathology, Medical Academy in Dresden; in <strong>the</strong> Institute <strong>of</strong> Medical Immunology in Berlin; in <strong>the</strong><br />
Institute <strong>of</strong> Pathology, University <strong>of</strong> Rostock, Germany, 1987-1988; Participation in <strong>the</strong> course<br />
"Immunocytochemical methods and monoclonal antibodies in oncology, hematology and clinical<br />
immunology", Kiev, Ukraine, March 1990; Visiting scientist, Medical University <strong>of</strong> Lübeck, Germany,<br />
July, August 1990; Visiting scientist, Institute <strong>of</strong> Pathology, University <strong>of</strong> Göttingen, Germany, August,<br />
September 1992; Visiting scientist, Laboratory <strong>of</strong> Medical Microbiology, University <strong>of</strong> Lund, Sweden,<br />
March 1993, June-July 1994, July 1996; Participation in <strong>the</strong> Summer School Course "Immunology-93",<br />
Palanga, Lithuania, June, 1993; Visiting scientist, <strong>Department</strong> <strong>of</strong> Gastroenterology Inselspital Bern<br />
and in <strong>the</strong> Institute <strong>of</strong> Pathology, University <strong>of</strong> Bern, Switzerland, January-March 1994, May 1997;<br />
Participation in <strong>the</strong> post-graduate course "Autoimmunity: Basic and Clinical", organized at <strong>the</strong><br />
University <strong>of</strong> Tartu, Estonia, on June 5-12, 1994; Participation in <strong>the</strong> 1st International Technical<br />
Course on Helicobacter pylori, University <strong>of</strong> Bordeaux, France, September 4-16, 1994; Participation in<br />
<strong>the</strong> International Course on Gastric Cancer and Helicobacter pylori , San Marino, October 2-5, 1995;<br />
Attending <strong>the</strong> Helicobacter pylori: Basic mechanisms to clinical cure 1996 symposium in Ottawa,<br />
Ontario from June 10-12, 1996 as continuing medical education activity for 20.5 hours as category 1 <strong>of</strong><br />
<strong>the</strong> Physician’s recognition Award <strong>of</strong> <strong>the</strong> Americal medical association; Participation in Salzburg-<br />
Cornell Seminar in Oncology, July 27-Augst 2 1997. Salzburg Austria; Participation in SAS System<br />
computer course, October 1997, University <strong>of</strong> Tartu. Participation in European Helicobacter pylori Study<br />
Group Gastric Pathology Course, February 7/8th 1998. Northick Park & St Mark’ Hospitals London, UK;<br />
Participation in Nordic Summer School in Methods <strong>of</strong> Infectious Disease Epidemiology. Söderfors,<br />
Sweden, 8-17 June 1998; Visiting scientist, Institute <strong>of</strong> Pathology, University Erlangen-Nürnberg,<br />
Germany, October-November, 1998; Participation in International Summer School <strong>of</strong> Immunology,<br />
Jurmala, Latvia, 24-28 May, 1999. ;Participation in language course “ How to write scientific papers”,<br />
organized by Helsinki University in Tartu, May 2000. Administrative experience: Member <strong>of</strong> <strong>the</strong><br />
Organizing Committee for <strong>the</strong> post-graduate course "Autoimmunity: Basic and Clinical", organized at<br />
<strong>the</strong> University <strong>of</strong> Tartu, Estonia, 1994. Honours and awards: Estonian Governement Scientific Award for<br />
1994: H.-I. Maaroos, T. Vorobjova, R.Uibo, K.Kisand, R. Tammur, T. Kivik, K. Villako. - The occurrence <strong>of</strong><br />
Helicobacter pylori infection in <strong>the</strong> Estonian population; Award <strong>of</strong> Medical Faculty <strong>of</strong> University <strong>of</strong> Tartu,<br />
1999. Membership in academic and scientific societies: Member <strong>of</strong> Estonian Society <strong>of</strong><br />
Gastroenterology, since 1980; Secretary <strong>of</strong> <strong>the</strong> Estonian Society for Immunology, since 1984; Member <strong>of</strong><br />
<strong>the</strong> Organizing Committee for <strong>the</strong> I Congress <strong>of</strong> Estonian Society for Immunology, 1989; Member <strong>of</strong> <strong>the</strong><br />
206
IMMUNOLOGY<br />
Board <strong>of</strong> <strong>the</strong> Baltic Immunological Society, since 1991; Member <strong>of</strong> <strong>the</strong> German-Baltic Physicians Society,<br />
since 1991. Current research program and grants: Immune response to Helicobacter pylori and its<br />
association with dynamics <strong>of</strong> chronic gastritis and epi<strong>the</strong>lial cell turnover in antrum and corpus. Grants:<br />
Estonian Science Foundation Grant 4383 ”Prospective follow-up study <strong>of</strong> peptic ulcer and chronic<br />
gastritis after eradication <strong>of</strong> Helicobacter pylori: accent on factors influencing regeneration <strong>of</strong> gastric<br />
mucosa and quality <strong>of</strong> life <strong>of</strong> patients” ;Ministry <strong>of</strong> education TARMP0420 “Pathogenetic mechanisms<br />
<strong>of</strong> autoimmunity and immunodiagnostics” (1998-2002); 3. Estonian Science Foundation grant No.<br />
3045 “Development <strong>of</strong> novel methods for <strong>the</strong> diagnosis <strong>of</strong> autoimmunity” (1997-2000) Supervision <strong>of</strong><br />
dissertations: no Publications: 72; Thesis: 1 (Cand Sci); Papers: 24; International Journals: 16;<br />
Estonian Journals: 2 Tartu University Press: 6; Abstracts: 47<br />
KISAND, KAI Date <strong>of</strong> birth: March 8, 1965 Gender: female Citizenship: Estonian Address:<br />
Immunology Research Group; Institute <strong>of</strong> General and molecular Pathology, University <strong>of</strong> Tartu; Ravila<br />
19, Tartu 51014, Estonia Educational history: Licentiate <strong>of</strong> Medicine (M.D.), University <strong>of</strong> Tartu,<br />
Estonia, 1989; 1992-1998 postgraduate studies, University <strong>of</strong> Tartu Academic degrees: Dr.Med,<br />
University <strong>of</strong> Tartu, Estonia, 1999 Employment and pr<strong>of</strong>essional experience: 1989 - research<br />
assistant in Laboratory <strong>of</strong> Immunology, University <strong>of</strong> Tartu; from 1999 researcher in Immunology<br />
Research Group; 1993 - Fellowship at <strong>the</strong> <strong>Department</strong> <strong>of</strong> Pathology <strong>of</strong> <strong>the</strong> Institute <strong>of</strong> Medical<br />
Technology, University <strong>of</strong> Tampere, Finland (three months); 1994 - International course<br />
"Autoimmunity: Basic and Clinical" (Tartu); 1995- Falk Symposium No. 86. Bile Acids and Immunology<br />
(Basel); 1996 -XXVIIth Meeting <strong>of</strong> <strong>the</strong> Scandinavian Society for Immunology (Turku); 1998 - European<br />
Mucosal Immunology Meeting (London); 1999 - Autoantibodies and Autoimmunity (Oslo); 1999 - one<br />
week at <strong>the</strong> <strong>Department</strong> <strong>of</strong> Virology, University <strong>of</strong> Tampere studying RT-PCR for enterovirus infection<br />
detection; 2000 - one week in University <strong>of</strong> Turku studying lymphocyte proliferation assay; 2000 -<br />
Baltic Summer School: Current Trends in Immunology and Signal Transduction (Kiel, 2000, tree<br />
weeks); experience <strong>of</strong> teaching immunology from 1992 (seminars) Administrative experience:<br />
Member <strong>of</strong> local organizing committees: 1 st Estonian Congress <strong>of</strong> Immunology (1989); International<br />
Course ″Autoimmunity: Basic and Clinical″ (1994) Honours and awards: Award <strong>of</strong> medical faculty,<br />
University <strong>of</strong> Tartu, 2000; Membership in academic and scientific societies: Member <strong>of</strong> Estonian<br />
Immunological Society; Member <strong>of</strong> Baltic Immunnological Society Current research program and<br />
grants: enteroviruses in autoimmune diseases, functional properties <strong>of</strong> autoantibodies in primary<br />
biliary cirrhosis, cellular immunity in patients with Down’s syndrome Supervision <strong>of</strong> dissertations: no<br />
Publications: 25 (from which 5 in international journals)<br />
REIMAND, KOIT Date <strong>of</strong> birth:19.07.1968 Gender: male Citizenship:Estonian Address:Hurda 18-1,<br />
51005, Tartu, Estonia Educational history: Internship in University <strong>of</strong> Tartu, Medical Faculty<br />
01.08.1993 – 20.06.1995; medical student in University <strong>of</strong> Tartu, Medical Faculty 01.09.1986 –<br />
22.06.1993; secondary education – Tartu 1. Secondary School, 1986; primary education – Tartu 10.<br />
Secondary School, 1983 Academic degrees (with year and university): M.D., 1993, University <strong>of</strong><br />
Tartu Employment and pr<strong>of</strong>essional experience: From 1993 to 1994 - technician in <strong>the</strong> Laboratory<br />
<strong>of</strong> Immunology, University <strong>of</strong> Tartu; from 1995 – assistant, chair <strong>of</strong> immunology, University <strong>of</strong> Tartu;<br />
Experienced as a tutor <strong>of</strong> seminars and practical laboratory course in immunology, also as laboratory<br />
supervisor <strong>of</strong> student research work; Participation in courses: June and August, 1996, University <strong>of</strong><br />
Tampere – Basic Techniques in Molecular Biology I and II, practical course; November, 1996,<br />
University <strong>of</strong> Tampere – Screening <strong>of</strong> cDNA Expression Library for Autoantigen Identification, practical<br />
course (co-leader <strong>of</strong> <strong>the</strong> course). January 1997, University <strong>of</strong> Tartu – Pedagogy and educational<br />
psychology training course. Administrative experience: no Honours and awards: no Membership in<br />
academic and scientific societies: Member <strong>of</strong> Estonian Society for Immunology Current research<br />
program and grants: Organ-specific autoimmunity, focused to endocrine and reproductive<br />
autoimmunity Grants: EI INCO-Copernicus IC15CT98-0316 Enterovirus infections in NIS/CEE<br />
countries and in EU – importance for population health and pathogenesis <strong>of</strong> IDDM (1992-2002);<br />
Ministry <strong>of</strong> education TARMP0420 Pathogenetic mechanisms <strong>of</strong> autoimmunity and immunodiagnostics<br />
(1998-2002); Estonian Science Foundation grant No. 4437 Mechanisms <strong>of</strong> autoimmunity development<br />
in Down’s syndrome (2000-2002) Supervision <strong>of</strong> dissertations: no Publications: 4<br />
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