Anna Olsson

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Study design: the need for qualified personnel • Optimal number of animals – again a standard question • Power analysis or equivalent to estimate animal numbers • However dependent on specialized knowledge only a scientist from the field knows: variation, size of biologically relevant effect etc Study design: the need for qualified personnel • More efficient to educate the scientists and to require them to consult with statisticians than to try to cover this aspect in detail in the committee • It may still be useful for the committee to have a statistician linked to them to discuss protocols that seem weak or otherwise complicated 6/7/2009 12
Reduction and standardization • Standardizing to reduce number of animals • Narrowing down the range of conditions (sex, age, genotype) reduces the potential for extrapolation • Consider possible culling of animals if only one sex used Reduction and standardization • Narrowing down the range of conditions reduces the potential for extrapolation • Systematic variation rather than increased variation (e g several inbred strains rather than one outbred, several housing conditions) • Animal studies in general use too few animals – n for animal studies much smaller than the reduction in variation (compared to human clinical trials) justifies 6/7/2009 13
Page 1 and 2: Ethics review of animal-based resea
Page 3 and 4: Checklist for ethics reviews • De
Page 5 and 6: Replacement • Is there a precise
Page 7 and 8: Refinement • Is there a descripti
Page 9 and 10: Limited benefit as a reason to deny
Page 11: Responsibility and authority: human
Page 15 and 16: Ensuring scientific validity • Sc
Page 17 and 18: Appropriate level of review • The

Anna Olsson

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