Anna Olsson

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Replacement alternatives • Standard question - under present directive, llegal to use animals if nonanimal method exist • Replacement alternatives exist mainly for some standard procedures (toxicity) + teaching • Replacement in science generally means a change of approach – attitudes of scientists rather than ethics committee decisions Responsibility and authority: humane endpoints • HEP means that data collection from an animal stops when it has reached predefined clinical status • Potential conflict of interest between many involved: – Animal caretakers / technicians inspecting animal – Scientist running study – Veterinarian responsible for animal welfare in the facility 6/7/2009 10
Responsibility and authority: humane endpoints • Not applying HEPs when they should be applied means more suffering than necessary • Veterinary decision carries most weight (ETS123, 86/609/EEC) • Involving all personnel in planning to prevent conflicts • Ethics committee to handle conflicts adhoc Severity banding • Speed up procedure • Transparency • Severity: number or an equivalent term (e.g. “moderate”), with various and quite often obscure underlying algorithms of calculation • Making this procedure too automatic risks the quality 6/7/2009 11
Page 1 and 2: Ethics review of animal-based resea
Page 3 and 4: Checklist for ethics reviews • De
Page 5 and 6: Replacement • Is there a precise
Page 7 and 8: Refinement • Is there a descripti
Page 9: Limited benefit as a reason to deny
Page 13 and 14: Reduction and standardization • S
Page 15 and 16: Ensuring scientific validity • Sc
Page 17 and 18: Appropriate level of review • The

Anna Olsson

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