Gyula Demeter

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Authors Samples Medication Performance Conclusions/Comments Zohar et al. (1999) N=18 OCD females N=14 OCD male medication free for at least 2 weeks Deckerscbach et al. (2000) N= 17 OCD medication free for at least 2 weeks Okasha et al. (2000) N= 30 OCD N= 30 HC Basso et al. (2001) N= 20 OCD N= 31 HC Moritz et al. (2001) N= 36 OCD N= 17 high depression score N= 19 low depression score N= 36 HC Mataix-Cols et al. (2002) N= 28 medicated OCD N= 24 unmedicated OCD Moritz et al. (2002) N= 25 OCD N= 25 SCH N= 25 D N= 25 HC Lacerda et al. (2003) N=14 OCD N=14 HC Whitney et al. (2004) N=11 OCD N=26 SCH with obsessivecompulsive symptoms N=28 SCH without obsessivecompulsive symptoms medication free for at least 2 weeks 3 patients were unmedicated 20 patients were medicated SRI-medicated vs. SRI-free fro at least 2 weeks 14 OCD, 20 D and all SCH patients were medicated no difference WCST performance negatively correlated with symptom severity in females and positively in males – sexual dimorphism no difference from statistical norms in OCD no consistent association between shifting ability, verbal fluency, and memory scores impaired frontocortical dysfunction in OCD impaired executive deficit is related to comorbid depression impaired – only patients with high depression score the study of executive function in OCD must account for comormid depressive symptoms no difference SRI don’t have a significant impact on the WCST performance no difference in OCD; just D and SCH group vs. control need for more fine-grained tasks in the study of neuropsychological functions medication free impaired positive correlations were observed between nonperseverative errors and rCBF in frontal areas and anterior cingulated, while perseverative errors correlated negatively with all patients were under psychiatric treatment rCBF in the right thalamus no difference comorbid individuals haven’t demonstrated significantly lower performance, just a statistical trend could be observed 22
Authors Samples Medication Performance Conclusions/Comments Roh et al. (2005) N= 20 OCD N= 20 HC Rao et al. (2008) N=30 recovered OCD N=30 HC Kitis et al. (2007) N=23 OCD N=24 SCH N=22 HC Shin et al. (2008) N=17 N=25ADHD N=21 tic disorder N=20 D N=23HC Nakao et al. (2009) N=40 OCD N=25 HC Cavedini et al. (2010) N=35 OCD N=35 unaffected first degree relatives Mukhopadhyay et al. (2010) N=31 HC N=20 OCD N=20 HC Bradbury et al. (2011) N=10 High Beliefs OCD N=11 Low Beliefs OCD N=13 PDA N=13 SP undermedication impaired executive function impairment together with visuospatial memory and fluency deficit may 28 patients were on SRI; 8 of them were also on clonazepam and one was on ziprasidone 11 OCD patients were on antidepressant therapy, 2 were on combination of antidepressants and antipsychotics and 10 were medication free; from the SCH group 2 patients were medication free six of the subjects in the OCD group were taking fluoxetine, sertraline or risperidone medication free for at least 2 weeks impaired (completed category) no difference from HC; SCH performance was impaired compared to OCD impaired compared to HC no difference (OCD patients tended to achieve fewer category) underlay the pathology neuropsychological deficits are as candidate endophenotype markers for OCD; certain executive functions are probably state independent cognitive dysfunctions in OCD may be related to overvalued ideas; there were no significant differences in cognitive functions between SCH group and the OCD patients who had higher scores on the Overvalued Ideas Scale study with children; support near the fronto-striatal deficit hypothesis symptom severity and symptom subtype such as obsessions/checking might affect neuropsychological dysfunction and related brain activities not mentioned no difference executive dysfunction as possible endopehontypic marker in OCD – decision making and planning not mentioned impaired it offers an approach to understand instinctual impulses from neuropsychological not mentioned the High Beliefs OCD group performed significantly worst perspective argue near a possible connection between heightened obsessive beliefs and cognitive inflexibility 23
Page 1 and 2: Budapest University of Technology a
Page 3 and 4: 6.3. Study 3: Over-monitoring secon
Page 5 and 6: Glossary of abbreviations ACC Anter
Page 7 and 8: WCST-LS Wisconsin Card Sorting Task
Page 9 and 10: Kivonat Az obszesszív-kompulzív z
Page 11 and 12: Introduction In our daily life we r
Page 13 and 14: Chapter 1. Overview of Obsessive co
Page 15 and 16: ilaterally at the ventromedial pref
Page 17 and 18: Chapter 2. The study of executive f
Page 19 and 20: 2.2. Theories and measurement of ex
Page 21 and 22: outcomes etc.) which in many labora
Page 23 and 24: As far as we know no executive task
Page 25 and 26: The tasks that are most commonly us
Page 27 and 28: 2002) and on the Intra-Dimensional/
Page 29 and 30: Inhibition In the Miyake et al. (20
Page 31: Table 1. Summary of OCD patients re
Page 35 and 36: Chapter 3. The study of memory func
Page 37 and 38: 3.2. Prospective memory Prospective
Page 39 and 40: 3.2.1. Theories of prospective memo
Page 41 and 42: According to Guynn (2008) retrieval
Page 43 and 44: intention or the initiation and exe
Page 45 and 46: 3.2.3. Studying PM in OCD While at
Page 47 and 48: 3.2.4. A possible PM model of OCD O
Page 49 and 50: 3.3. The role of inhibition in sele
Page 51 and 52: Further two recent results will be
Page 53 and 54: it, (3) the neuropsychological impa
Page 55 and 56: 4.3. Current neurobiological model
Page 57 and 58: The role of amygdale in the express
Page 59 and 60: 5.1. Main goals 1. To assess the le
Page 61 and 62: Chapter 6. Studies 6.1. Study 1: Im
Page 63 and 64: impairment in this task 15 and othe
Page 65 and 66: Procedure All OCD patients received
Page 67 and 68: series of equal length, and we cons
Page 69 and 70: called error inhibition index (SEII
Page 71 and 72: Reaction Time Colour Naming Conditi
Page 73 and 74: which might be impaired in OCD. 9 I
Page 75 and 76: REFERENCES 1. American Psychiatric
Page 77 and 78: 20. van der Wee NJ., Ramsey NF, Jan
Page 79 and 80: 39. Goodman WK, Price LH, Rasmussen
Page 81: 6.2. Study 2: Impaired prospective
Page 89 and 90:
Table 1 Sample demographics and bas
Page 91 and 92:
Written instructions were read to t
Page 93 and 94:
Table 2 Hit rate in the two experim
Page 95 and 96:
Comparison of patient and healthy a
Page 97 and 98:
can be concluded that OCD patients
Page 104 and 105:
6.5. Study 5: No retrieval induced
Page 106 and 107:
Experimental design and materials T
Page 108 and 109:
Procedure “In the study phase, pa
Page 110 and 111:
RIF effect in the control group, t(
Page 112 and 113:
Chapter 7. Discussion, conclusions
Page 114 and 115:
and retrospective memory processes
Page 116 and 117:
Bjork, & Bjork, 1994), which was of
Page 118 and 119:
of the dACC contributes to the pers
Page 120 and 121:
of patients’ cognitive abilities
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Anderson, M. C., & Spellman, B. A.
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Kearns, N. P., Cruickshank, C. A.,
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Levy, B. J., & Anderson, M. C. (200
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Thordarson, D. S., Radomsky, A. S.,
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Wincze, J. (2001). The role of unde
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Gyula Demeter

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