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Wound Care

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Principles of Skin and <strong>Wound</strong> <strong>Care</strong> 51<br />

Deficiency of folate causes:<br />

º Megaloblastic anemia<br />

º NOTE: many drugs affect folate use by body tissues<br />

Zinc (Zn): daily requirement for men is 15 mg and for<br />

women is 12 mg<br />

Function of zinc:<br />

º Cell proliferation & healing<br />

º Cofactor for enzymes<br />

Deficiency of zinc causes:<br />

º Prolonged healing time<br />

º Anorexia<br />

º Taste alteration<br />

º ↓ immunity<br />

— Iron (Fe): daily requirement for men is 10 mg/day and for<br />

women is 15 mg/day<br />

— Function of iron:<br />

Collagen synthesis<br />

Enhances leukocytic bacterial activity<br />

Oxygen transport to cells<br />

— Deficiency of iron causes:<br />

Leads to risk of local tissue ischemia due to anemia<br />

Impaired tensile strength<br />

Impaired collagen cross-linkage<br />

— Copper (Cu): 1.5–3.0 mg/day<br />

— Function of copper:<br />

Collagen cross-linkage<br />

Component of wound healing<br />

Nerve fiber protection<br />

— Deficiency of copper causes:<br />

Decreased collagen synthesis<br />

Bone demineralization and anemia

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