11 Neurogenesis and Gliogenesis Neurogeneisis is the formation of new neuronal cells. Once thought only to occur in developing organisms, recent studies have shown that neurogeneis occurs through an organism’s lifespan and plays a crucial role in neuron plasticity. Gliogeneisis is the formation of non-neuronal glia population. Glia cells function to support neural cells by providing physical structure and insulation, supplying nutrients and destroying pathogens. The Notch signaling pathway plays a major regulatory role in both events which are also affected by the Wnt and SHH pathways. Disruption of these processes has been implicated in several neurodegenerative diseases including Parkinson’s and Multiple Sclerosis. Related Antibodies • AKT • alpha Catenin • Axin 1, 2 • beta Catenin • CCL12 • CCL2 • CNTF • CSPG4P5 • Delta 1, 3, 4 • Dishevelled • EGF • Eotaxin • FGF • GABA • gamma-Secretase • GFAP • Glutamate Receptor 5 • HIP1 • IGF1 Delta 1, 3, 4 Jagged 1, 2 Notch 1, 2, 3, 4 • IGF1 Receptor • Jagged 1, 2 • JAK 1, 2, 3 • LRP2 • LRP5/6 • MASH1 • Neurogenin 1 • NMDA • Notch1 • NRG1 • NUMB • OLIG2 • PACAP Receptor • Sonic Hedgehog • SS18L1 • Stat 1–6 • TGF alpha • VIP • Wnt Overview of the Notch Signaling Pathway γ-Secretase NICD HDAC CoR CSL X CoA MAML p300 NICD CSL Customer Reviews PPAR delta Antibody (NB600-637) Application: IHC-P Sample Tested: Gerbil stomach Species: Gerbil AKT1 Antibody (NB600-467) Application: Western blot Sample Tested: Mouse spleen lysate Species: Mouse FGFR1 Antibody (M19B2) (NB600-1287) Application: FACS Sample Tested: Transfected cell line Species: Rat Notch 1 Antibody NBP1-78292 Species: Hu, Mu Applications: WB, IHC-P Immunohistochemical analysis in human kidney using NBP1-78292.
eta Catenin Antibody (12F7) Antibody NBP1-54467 IGF1 Receptor Antibody NBP1-77679 NUMB Antibody NB500-178 Western blot analysis in 1. HepG2, 2. MCF7, and 3. Cos7 whole cell lysates using NBP1-54467. Species: Hu, Mu, Rt, Ch, Mk Applications: WB, ICC, IF, IHC-P, IP Species: Hu, Mu, Rt, Mk Applications: WB, ICC, IF, IHC-P Species: Hu, Mu, Rt, Ch Applications: WB Product Citations Immunocytochemical analysis in A431 cells with FITC (green) using NBP1-77679. Western blot analysis of isoforms 1 and 2 in A431 whole cell lysate using NB500-178. Dishevelled 3 Antibody NBP1-68660 Immunohistochemical analysis of human brain tissue using NBP1-68600. Species: Hu, Mu Applications: ELISA, IHC Jagged1 Antibody NB600-1161 Immunofluorescent analysis of human corneal epithelial cells using NB600-1161. Species: Hu, Mu, Rt Applications: WB, ELISA, IF, IHC-P Sonic Hedgehog Antibody NBP1-69270 Immunohistochemical analysis of chicken embryos using NBP1-69270. Species: Hu, Mu, Rt, Ca, Ch, Xp, Ze Applications: WB, IHC-P HIP1 (4B10) Antibody NB300-203 Western blot on HeLa whole cell extracts using NB300-203. Species: Hu Applications: WB Neurogenin 1 (3F9) Antibody NBP1-47871 Immunohistochemical analysis of prostate tissue using NBP1-47871. Species: Hu Applications: WB, IHC-P Wnt1 (10C8) Antibody NBP1-51575 Immunofluorescent analysis of 3T3-L1 cells using NBP1-51575. Species: Hu, Mu Applications: WB, ELISA, FACS, IF, IHC-P [AKT2 Antibody NBP1-26594] Lin HP, Jiang SS, Chuu CP. Caffeic Acid Phenethyl Ester Causes p21 Induction, Akt Signaling Reduction, and Growth Inhibition in PC-3 Human Prostate Cancer Cells. PLoS One. 2012;7(2). [PMID: 22347457] [EGFR Antibody (29.1) NB120-10414] Kondratov, K.A., et al., Termination Of Tyrphostin AG1478 Application Results In Different Recovery Of EGF Receptor Tyrosine Residues 1045 And 1173 Phosphorylation In A431 Cells. Cell Biol. Int. 2010 34:81-87. [PMID: 19947936] [GABA A Receptor gamma 2 Antibody NBP1-52033] You IJ, Jung YH, Kim MJ, et al. Alterations in the emotional and memory behavioral phenotypes of transient receptor potential vanilloid type 1-deficient mice are mediated by changes in expression of 5-HT 1 A, GABA(A), and NMDA receptors. Neuropharmacology. 2012 Feb;62(2):1034-43. [PMID: 22074644] [GABA B Receptor 1 Antibody NB300-160] Luo C, Rajput AH, Robinson CA, Rajput A. Gamma- aminobutyric acid (GABA)-B receptor 1 in cerebellar cortex of essential tremor. J Clin Neurosci. 2012 Feb 7. [PMID: 22321358] [GABARAP Antibody NB300-158] Diaz MR, Christian DT, Anderson NJ, McCool BA. Chronic ethanol and withdrawal differentially modulate lateral/basolateral amygdala paracapsular and local GABAergic synapses. J. Pharmacol. Exp. Ther. 2011 Apr;337(1):162-170. [PMID: 21209156] [GFAP Antibody NB300-141] O’Donnell LA, Conway S, Rose RW, et al. STAT1-Independent Control of a Neurotropic Measles Virus Challenge in Primary Neurons and Infected Mice. J Immunol. 2012 Feb 15;188(4):1915-23. [PMID: 22246627] [HIP1 (1B11) Antibody NB300-204] Datta M, Bhattacharyya NP. Regulation of RE1 Protein Silencing Transcription Factor (REST) Expression by HIP1 Protein Interactor (HIPPI). J Biol Chem. 2011 Sep 30;286(39). [PMID: 21832040] [Notch1 Antibody NB300-251] Sciacca S, Pilato M, Mazzoccoli G, Pazienza V, Vinciguerra M. Anti-correlation between longevity gene SirT1 and Notch signaling in ascending aorta biopsies from patients with bicuspid aortic valve disease. Heart Vessels. 2012 Feb 28. [PMID: 22370592] [PKC delta (K15-K) Antibody NBP1-30125] Ku CS, Park Y, Coleman SL, Lee J. Unsaturated fatty acids repress expression of ATP binding cassette transporter A1 and G1 in RAW 264.7 macrophages. The Journal of Nutritional Biochemistry. 2011 Dec 29. [PMID: 22209005] 12