smallpox vaccine and vaccination in the intensified ... - libdoc.who.int

11. VACCINATION IN THE INTENSIFIED PROGRAMME
Table 1 1.12. WHO quality control of freeze-dried vaccine used in the lntensified Smallpox Eradication
Programme: results of tests carried out in WHO reference centres for smallpox vaccine in
Bilthoven and Toronto on samples submitted from the field
Year
Number unsatlsfactory
Number of Number of batches Number satlsfactory
producers submitted (90) lnitlal Heat
potency stability
Total - 377 279 79 19
there was a general improvement in quality, countries. Although there was a distinct
suggesting that vaccine supplies were being overall improvement, problems continued to
more carefully handled in the countries in occur. Table 11.13 shows the results of quality
which they were used. control tests by WHO reference laboratories
of batches produced during the period 1971-
Results in dgerent regions
1974.
In South America, Brazil was the onlv
By 1971 the quality control operation country in which smallpox was still endemic
covered 41 laboratories producing vaccine for in 1967, but the quality of the vaccine
national eradication campaigns, for donation produced in 3 of its 4 production laboratories,
to WHO or for bilateral assistance to endemic most of which was grown in eggs, often failed
Table 1 1.13. WHO quality control of vaccine in use for the lntensified Smallpox Eradication Programme:
results of tests carried out, by WHO region
WHO region
1971 1972 1973 1974
Number
of
Number of batches Number of batches Number of batches Number of batches
Tested Satisfactory Tested Satisfactory Tested Satisfactory Tested Satlsfactory
Africa 2a 5 5 32 28 2 2 24 2 1
Amerlcas I lb 24 14 58 29 30 28 33 17
South-East Asia BC 107 103 120 108 253 245 86 83
Europe 1 3 ~ 27 2 1 17 15 29 27 42 38
Eastern
Medlterranean 3e I I 4 67 54 54 49 29 29
Western Paciflc 4f 6 6 6 6 9 9 - -
Total 41 180 153 300 240 377 360 214 188
htlsfactory (90) 85 80 95 88
a Guinea, Kenya.
Argentina, Brazil (4), Canada, Colombia, Ecuador, Peru, Venezuela, USA.
C Bangladesh, Burma, Indh (4), Indonesia, Thailand.
Belgium, Czechoslovakia, Flnland, France, German Democratlc Republlc, Federal Republlc of Germany, Hungary, Netherlands, Sweden,
Switzerland, USSR, United Kingdom, Yugoslavia.
elran, Iraq, Syrian Arab Republic.
f~hina (Provlnce of Talwan), New Zealand, Philippines, Vlet Nam.
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