Neonatal Cholestasis

Clinical Features
History: Variable degrees of persistent jaundice,
dark urine, light colored stools, +/-poor appetite
* Usually Well-Appearing*
Physical:
Hepatomegaly, +/- splenomegaly
“appear” well-nourised
Usually with decreased fat stores and lean body mass
Enlarged abdomen from HSM may give impression of
“normal weight for age”
Scleral icterus, abdominal wall veins (caput medusa)
Labs:
Total bilirubin rarely is >12mg/dL; CB is usually